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https://www.readbyqxmd.com/read/29473753/macrophage-membrane-coated-nanoparticles-for-tumor-targeted-chemotherapy
#1
Yu Zhang, Kaimin Cai, Chao Li, Qin Guo, Qinjun Chen, Xi He, Lisha Liu, Yujie Zhang, Yifei Lu, Xinli Chen, Tao Sun, Yongzhuo Huang, Jianjun Cheng, Chen Jiang
Various delivery vectors have been integrated within biologically derived membrane systems to extend their residential time and reduce their reticuloendothelial system (RES) clearance during systemic circulation. However, rational design is still needed to further improve the in situ penetration efficiency of chemo-drug-loaded membrane delivery-system formulations and their release profiles at the tumor site. Here, a macrophage-membrane-coated nanoparticle is developed for tumor-targeted chemotherapy delivery with a controlled release profile in response to tumor microenvironment stimuli...
February 23, 2018: Nano Letters
https://www.readbyqxmd.com/read/29468887/managing-behavioral-and-psychological-symptoms-in-chinese-elderly-with-dementia-via-group-based-music-intervention-a-cluster-randomized-controlled-trial
#2
Rainbow Th Ho, Ted Ct Fong, C Y Sing, Pandora Ht Lee, Alice Bk Leung, Kitty Sm Chung, Janet Kl Kwok
The present study aimed to evaluate the effects of a group music intervention in managing behavioral and psychological symptoms in Chinese elderly with dementia. This cluster randomized trial recruited 73 elderly participants with moderate dementia from 10 elderly residential homes and assigned them to the intervention ( n = 40) and control ( n = 33) group. The intervention included 16 half-hour sessions of music intervention with multi-sensory components over eight weeks and control group received standard care...
January 1, 2018: Dementia
https://www.readbyqxmd.com/read/29464769/becoming-at-home-in-residential-care-for-older-people-a-material-culture-perspective
#3
Melanie Lovatt
Residential homes encourage new residents to bring belongings with them, so that they can personalise their room and 'feel at home'. Existing literature on material culture in residential homes views objects as symbols and repositories of home and identity, which can facilitate a sense of belonging in residents through their display in residents' rooms. I suggest that this both misunderstands the processual and fluid nature of home and identity, and conceptualises objects as essentially passive. This article uses ethnographic data and theories of practice and relationality to argue that rather than the meaning of home being inherent in objects, or felt subjectively by residents, meaning is generated through ongoing, everyday interactions between the two...
February 2018: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29459471/gender-sex-as-a-social-determinant-of-cardiovascular-risk
#4
REVIEW
Adrienne O'Neil, Anna J Scovelle, Allison J Milner, Anne Kavanagh
The social gradient for cardiovascular disease (CVD) onset and outcomes is well established. The American Heart Association's Social Determinants of Risk and Outcomes of Cardiovascular Disease Scientific Statement advocates looking beyond breakthroughs in biological science toward a social determinants approach that focuses on socioeconomic position, race and ethnicity, social support, culture and access to medical care, and residential environments to curb the burden of CVD going forward. Indeed, the benefits of this approach are likely to be far reaching, enhancing the positive effects of advances in CVD related to prevention and treatment while reducing health inequities that contribute to CVD onset and outcomes...
February 20, 2018: Circulation
https://www.readbyqxmd.com/read/29458377/out-of-hospital-cardiac-arrest-in-the-home-can-area-characteristics-identify-at-risk-communities-in-the-republic-of-ireland
#5
Siobhán Masterson, Conor Teljeur, John Cullinan, Andrew W Murphy, Conor Deasy, Akke Vellinga
BACKGROUND: Internationally, the majority of out-of-hospital cardiac arrests where resuscitation is attempted (OHCAs) occur in private residential locations i.e. at home. The prospect of survival for this patient group is universally dismal. Understanding of the area-level factors that affect the incidence of OHCA at home may help national health planners when implementing community resuscitation training and services. METHODS: We performed spatial smoothing using Bayesian conditional autoregression on case data from the Irish OHCA register...
February 20, 2018: International Journal of Health Geographics
https://www.readbyqxmd.com/read/29451904/phytoforensics-trees-as-bioindicators-of-potential-indoor-exposure-via-vapor-intrusion
#6
Jordan L Wilson, V A Samaranayake, Matt A Limmer, Joel G Burken
Human exposure to volatile organic compounds (VOCs) via vapor intrusion (VI) is an emerging public health concern with notable detrimental impacts on public health. Phytoforensics, plant sampling to semi-quantitatively delineate subsurface contamination, provides a potential non-invasive screening approach to detect VI potential, and plant sampling is effective and also time- and cost-efficient. Existing VI assessment methods are time- and resource-intensive, invasive, and require access into residential and commercial buildings to drill holes through basement slabs to install sampling ports or require substantial equipment to install groundwater or soil vapor sampling outside the home...
2018: PloS One
https://www.readbyqxmd.com/read/29448198/assessment-of-soil-metal-concentrations-in-residential-and-community-vegetable-gardens-in-melbourne-australia
#7
Mark A S Laidlaw, Dileepa H Alankarage, Suzie M Reichman, Mark Patrick Taylor, Andrew S Ball
Gardening and urban food production is an increasingly popular activity, which can improve physical and mental health and provide low cost nutritious food. However, the legacy of contamination from industrial and diffuse sources may have rendered surface soils in some urban gardens to have metals value in excess of recommended guidelines for agricultural production. The objective of this study was to establish the presence and spatial extent of soil metal contamination in Melbourne's residential and inner city community gardens...
February 8, 2018: Chemosphere
https://www.readbyqxmd.com/read/29444736/recognition-of-the-complexity-facing-residential-care-homes-a-practitioner-inquiry
#8
Jenny Dudman, Julienne Meyer, Cheryl Holman, Wendy Moyle
Aim To explore the experiences and challenges for residential care home staff when managing the healthcare needs of their residents, in particular those living with dementia. BACKGROUND: Increasing number of older people, with complex health and social care needs are living in residential care homes. Yet there is limited appreciation of why staff sometimes struggle to manage residents' healthcare needs, or understanding of their working relationship with district nurses (DNs), whose responsibility it is to provide nursing support...
February 15, 2018: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/29441737/cesium-137-contaminated-roads-and-health-problems-in-residents-an-epidemiological-investigation-in-seoul-2011
#9
Mina Ha, Young Su Ju, Won Jin Lee, Seung Sik Hwang, Sang Chul Yoo, Kyung Hwa Choi, Eunae Burm, Jieon Lee, Yun Keun Lee, Sanghyuk Im
BACKGROUND: In 2011, two roads in a residential area in Seoul were found to be contaminated with the radionuclide cesium-137 (137Cs). In response to public concerns, an epidemiological study was conducted. METHODS: The standardized cancer incidence ratios in the affected and neighboring regions were calculated based on the central cancer registry. Households in the region were sampled using the random stratified sampling technique, and questionnaires were administered to family members, via home visit and via students in elementary to high schools...
February 26, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29439392/the-uncertain-geographic-context-problem-in-the-analysis-of-the-relationships-between-obesity-and-the-built-environment-in-guangzhou
#10
Pengxiang Zhao, Mei-Po Kwan, Suhong Zhou
Traditionally, static units of analysis such as administrative units are used when studying obesity. However, using these fixed contextual units ignores environmental influences experienced by individuals in areas beyond their residential neighborhood and may render the results unreliable. This problem has been articulated as the uncertain geographic context problem (UGCoP). This study investigates the UGCoP through exploring the relationships between the built environment and obesity based on individuals' activity space...
February 10, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29432049/polybrominated-diphenyl-ethers-pbdes-in-car-and-house-dust-from-thailand-implication-for-human-exposure
#11
Dudsadee Muenhor, Stuart Harrad
This study examines concentrations of tri- to hexa-bromodiphenylethers (BDEs 17, 28, 47, 49, 66, 85, 99, 100, 153 and 154; Σ10PBDEs (polybrominated diphenyl ethers)) in car (n = 30) and house dust samples (n = 53) collected from different provinces in Thailand. The specific objectives of this study were: (i) to monitor levels of tri- to hexa-bromodiphenylethers (BDEs 17, 28, 47, 49, 66, 85, 99, 100, 153 and 154; Σ10PBDEs) in vehicle and residential dust sampled from various provinces in Thailand; (ii) to compare PBDE concentrations with those detected for domestic and automobile dust in studies from other countries and (iii) to estimate exposure of the Thai population to the target PBDEs via dust ingestion...
February 12, 2018: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/29431129/cohort-profile-lifework-a-prospective-cohort-study-on-occupational-and-environmental-risk-factors-and-health-in-the-netherlands
#12
Marije Reedijk, Virissa Lenters, Pauline Slottje, Anouk Pijpe, Petra H Peeters, Joke C Korevaar, Bas Bueno-de-Mesquita, W M Monique Verschuren, Robert A Verheij, Inka Pieterson, Flora E van Leeuwen, Matti A Rookus, Hans Kromhout, Roel C H Vermeulen
PURPOSE: LIFEWORK is a large federated prospective cohort established in the Netherlands to quantify the health effects of occupational and environmental exposures. This cohort is also the Dutch contribution to the international Cohort Study of Mobile Phone Use and Health (COSMOS). In this paper, we describe the study design, ongoing data collection, baseline characteristics of participants and the repeatability of key questionnaire items. PARTICIPANTS: 88 466 participants were enrolled in three cohort studies in 2011-2012...
February 3, 2018: BMJ Open
https://www.readbyqxmd.com/read/29421398/integrating-travel-behavior-with-land-use-regression-to-estimate-dynamic-air-pollution-exposure-in-hong-kong
#13
Robert Tang, Linwei Tian, Thuan-Quoc Thach, Tsz Him Tsui, Michael Brauer, Martha Lee, Ryan Allen, Weiran Yuchi, Poh-Chin Lai, Paulina Wong, Benjamin Barratt
BACKGROUND: Epidemiological studies typically use subjects' residential address to estimate individuals' air pollution exposure. However, in reality this exposure is rarely static as people move from home to work/study locations and commute during the day. Integrating mobility and time-activity data may reduce errors and biases, thereby improving estimates of health risks. OBJECTIVES: To incorporate land use regression with movement and building infiltration data to estimate time-weighted air pollution exposures stratified by age, sex, and employment status for population subgroups in Hong Kong...
January 31, 2018: Environment International
https://www.readbyqxmd.com/read/29420658/comparing-residential-contamination-in-a-houston-environmental-justice-neighborhood-before-and-after-hurricane-harvey
#14
Jennifer A Horney, Gaston A Casillas, Erin Baker, Kahler W Stone, Katie R Kirsch, Krisa Camargo, Terry L Wade, Thomas J McDonald
INTRODUCTION: Polycyclic aromatic hydrocarbons (PAHs) are complex environmental toxicants. Exposure to them has been linked to adverse health outcomes including cancer, as well as diseases of the skin, liver, and immune system. Based on an ongoing community engagement partnership with stakeholder groups and residents, we conducted a small longitudinal study to assess domestic exposure to PAHs among residents of Manchester, an environmental justice neighborhood located in the East End of Houston, TX...
2018: PloS One
https://www.readbyqxmd.com/read/29417846/fall-hazards-within-senior-independent-living-a-case-control-study
#15
Daejin Kim, Margaret Portillo
AIM: The main purpose of this research was to identify significant relationships between environmental hazards and older adults' falling. BACKGROUND: Falls can present a major health risk to older persons. Identifying potential environmental hazard that increases fall risks can be effective for developing fall prevention strategies that can create safer residential environments for older adults. METHODS: The research included a retrospective analysis of 449 fall incident reports in two case-control buildings...
January 1, 2018: HERD
https://www.readbyqxmd.com/read/29407255/using-research-evidence-to-inform-staff-learning-needs-in-cross-cultural-communication-in-aged-care-homes
#16
David Gillham, Anita De Bellis, Lily Xiao, Eileen Willis, Ann Harrington, Wendy Morey, Lesley Jeffers
BACKGROUND: Developed countries worldwide are facing an unprecedented demand for aged care services, with recent migrants of diverse linguistic and cultural backgrounds increasingly recruited as care workers while at the same time there is growing cultural diversity among aged care residents. This situation is compounded by rapidly changing technology and varied educational levels of care workers from diverse backgrounds. OBJECTIVES: The objectives were threefold: to identify staff learning needs to enable them to provide high-quality cross-cultural care; to improve team cohesion; and identify preferred learning approaches...
February 2, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29396342/modeling-individual-exposures-to-ambient-pm2-5-in-the-diabetes-and-the-environment-panel-study-deps
#17
Michael Breen, Yadong Xu, Alexandra Schneider, Ronald Williams, Robert Devlin
Air pollution epidemiology studies of ambient fine particulate matter (PM2.5) often use outdoor concentrations as exposure surrogates, which can induce exposure error. The goal of this study was to improve ambient PM2.5 exposure assessments for a repeated measurements study with 22 diabetic individuals in central North Carolina called the Diabetes and Environment Panel Study (DEPS) by applying the Exposure Model for Individuals (EMI), which predicts five tiers of individual-level exposure metrics for ambient PM2...
January 19, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29384753/determinants-of-self-rated-health-in-older-adults-before-and-3-months-after-an-emergency-department-visit-a-prospective-study
#18
Floor J Van Deudekom, Jelle De Gelder, Jacinta A Lucke, Anneleen Oostendorp-Lange, Sander Anten, Gerard J Blauw, Bas De Groot, Simon P Mooijaart
OBJECTIVES: Self-rated health (SRH) is an important patient-reported outcome, but little is known about SRH after a visit to the emergency department (ED). We investigated the determinants of decline in SRH during 3 months after an ED visit in older patients. DESIGN: This was a multicenter prospective cohort study including acutely presenting older (≥70 years) patients in the ED (the Netherlands). Patients were asked to self-rate their health between 0 and 10...
January 30, 2018: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/29382378/filter-forensics-microbiota-recovery-from-residential-hvac-filters
#19
Juan P Maestre, Wiley Jennings, Dennis Wylie, Sharon D Horner, Jeffrey Siegel, Kerry A Kinney
BACKGROUND: Establishing reliable methods for assessing the microbiome within the built environment is critical for understanding the impact of biological exposures on human health. High-throughput DNA sequencing of dust samples provides valuable insights into the microbiome present in human-occupied spaces. However, the effect that different sampling methods have on the microbial community recovered from dust samples is not well understood across sample types. Heating, ventilation, and air conditioning (HVAC) filters hold promise as long-term, spatially integrated, high volume samplers to characterize the airborne microbiome in homes and other climate-controlled spaces...
January 30, 2018: Microbiome
https://www.readbyqxmd.com/read/29380847/development-and-psychometric-testing-of-a-novel-food-service-satisfaction-questionnaire-for-food-service-staff-of-aged-care-homes
#20
M Miller, J Hamilton, R Scupham, L Matwiejczyk, I Prichard, O Farrer, A Yaxley
BACKGROUND: Food service staff are integral to delivery of quality food in aged care homes yet measurement of their satisfaction is unable to be performed due to an absence of a valid and reliable questionnaire. The aim of this study was to develop and perform psychometric testing for a new Food Service Satisfaction Questionnaire developed in Australia specifically for use by food service staff working in residential aged care homes (Flinders FSSQFSAC). METHODS: A mixed methods design utilizing both a qualitative (in-depth interviews, focus groups) and a quantitative approach (cross sectional survey) was used...
2018: Journal of Nutrition, Health & Aging
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