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https://www.readbyqxmd.com/read/28231390/intraoperative-assessment-of-laryngeal-pathologies-with-optical-coherence-tomography-integrated-into-a-surgical-microscope
#1
Anna S Englhard, Tom Betz, Veronika Volgger, Eva Lankenau, Georg J Ledderose, Herbert Stepp, Christian Homann, Christian S Betz
OBJECTIVE: Endoscopic examination followed by tissue biopsy is the gold standard in the evaluation of lesions of the upper aerodigestive tract. However, it can be difficult to distinguish between healthy mucosa, dysplasia, and invasive carcinoma. Optical coherence tomography (OCT) is a non-invasive technique which acquires high-resolution, cross-sectional images of tissue in vivo. Integrated into a surgical microscope, it allows the intraoperative evaluation of lesions simultaneously with microscopic visualization...
February 23, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28231144/effects-of-two-step-transamidation-of-wheat-semolina-on-the-technological-properties-of-gluten
#2
Salvatore Moscaritolo, Lucia Treppiccione, Antonio Ottombrino, Mauro Rossi
Celiac disease (CD) is an immune-mediated disorder caused by the ingestion of wheat gluten. A lifelong, gluten-free diet is required to alleviate symptoms and to normalize the intestinal mucosa. We previously found that transamidation reaction by microbial transglutaminase (mTG) was effective in down-regulating the gliadin-specific immune response in CD patients. In this study, the two-step transamidation protocol was adopted to treat commercial wheat semolina on a pilot scale. The effectiveness of the enzymatic reaction was tested by means of consolidated biochemical and immunological methods on isolated prolamins...
June 29, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28230790/influence-of-chitosan-swelling-behaviour-on-controlled-release-of-tenofovir-from-mucoadhesive-vaginal-systems-for-prevention-of-sexual-transmission-of-hiv
#3
Fernando Notario-Pérez, Araceli Martín-Illana, Raúl Cazorla-Luna, Roberto Ruiz-Caro, Luis-Miguel Bedoya, Aitana Tamayo, Juan Rubio, María-Dolores Veiga
The main challenges facing efforts to prevent the transmission of human immunodeficiency virus (HIV) are the lack of access to sexual education services and sexual violence against young women and girls. Vaginal formulations for the prevention of sexually transmitted infections are currently gaining importance in drug development. Vaginal mucoadhesive tablets can be developed by including natural polymers that have good binding capacity with mucosal tissues, such as chitosan or guar gum, semisynthetic polymers such as hydroxypropylmethyl cellulose, or synthetic polymers such as Eudragit(®) RS...
February 21, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28230590/modified-lateral-surgical-approach-to-the-pterygopalatine-fossa
#4
Masataka Uehara, Masaaki Sasaguri, Shunji Shiiba, Kazuhiro Tominaga
Oral cancer, especially that originates in the maxillary tuberosity, buccal mucosa, and maxillary alveolus, is apt to invade the pterygopalatine fossa, where an intraoral approach is nearly impossible. There are 2 main types of extraoral approach to the pterygopalatine fossa; the anterior approach and the lateral approach. Although the lateral approach has an advantage compared with the anterior approach in terms of cosmetics, after the operation numbness of the lower lip occurs due to the sacrifice of the mental nerve...
February 22, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28230588/how-to-expose-the-entire-sella-floor-with-minimal-manipulation-during-an-endoscopic-endonasal-transsphenoidal-approach
#5
Do Hyun Kim, Yong-Kil Hong, Sin-Soo Jeun, Yong Jin Park, Soo Whan Kim, Jin Hee Cho, Boo-Young Kim, Sung Won Kim
OBJECTIVE: A method of opening the posterior ethmoid air cells with minimal manipulation is important for adequate exposure of the sella floor and minimal nasal morbidity. METHODS: Between February 2009 and August 2016, 373 patients with skull-base tumors underwent surgery via endoscopic endonasal transsphenoidal approach with the 2-nostrils/4-hands technique using this technique. RESULTS: A linear incision was made laterally toward one-third of the superior turbinate along the superior border of the sphenoid sinus ostium...
February 22, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28230087/nardilysin-regulates-inflammation-metaplasia-and-tumors-in-murine-stomach
#6
Yuto Kimura, Kozo Ikuta, Takeshi Kimura, Tsutomu Chiba, Hiroko Oshima, Masanobu Oshima, Eiichiro Nishi, Hiroshi Seno
Chronic inflammation contributes to a wide variety of human disorders. In the stomach, longstanding gastritis often results in structural alterations in the gastric mucosa, including metaplastic changes and gastric cancers. Therefore, it is important to elucidate factors that are involved in gastric inflammation. Nardilysin (N-arginine dibasic convertase; Nrdc) is a metalloendopeptidase of the M16 family that promotes ectodomain shedding of the precursor forms of various growth factors and cytokines by enhancing the protease activities of a disintegrin and metalloproteinase (ADAM) proteins...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28229922/mandevilla-longiflora-desf-pichon-improves-airway-inflammation-in-a-murine-model-of-allergic-asthma
#7
Danielle Ayr Tavares de Almeida, Suellen Iara Guirra Rosa, Thais Campos Dias da Cruz, Eduarda Pavan, Amílcar Sabino Damazo, Ilsamar Mendes Soares, Sérgio Donizeti Ascêncio, Antonio Macho, Domingos Tabajara de Oliveira Martins
ETHNOPHARMACOLOGICAL RELEVANCE: Mandevilla longiflora, popularly known as "velame" in central Brazil, is a subshrub and widely distributed in South America. Its xylopodium is used in the form of a decoction or infusion to treat inflammation and other ailments. AIM OF THE STUDY: This study aimed to evaluate the anti-inflammatory potential of M. longiflora in an in vivo model of ovalbumin-induced immediate hypersensitivity, identifying its effects on leukocyte infiltration, IgE and LTB4 levels, and Th2 cytokine production...
February 13, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28229607/therapeutic-impact-of-colon-capsule-endoscopy-with-pillcam%C3%A2-colon-2-after-incomplete-standard-colonoscopy-a-spanish-multicenter-study
#8
Óscar Nogales, Javier García-Lledó, Marisol Luján, David Nicolás, José Francisco Juanmartiñena, Begoña González-Suárez, Francisco Sánchez Ceballos, Ignacio Couto, José Olmedo, Cristina Garfia, Cristina Carretero, Ignacio Fernández Urién, Sarbelio Rodríguez, Matilde Asteinza, Pilar Olivencia, Ángeles Masedo, Miguel Muñoz-Navas, Beatriz Merino, Cecilia González Asanza
INTRODUCTION: Colon capsule endoscopy (CCE) is an alternative approach for the examination of the colon in patients who refuse colonoscopy or after incomplete colonoscopy (IC). We conducted a study to determine the frequency of complete colonoscopy after IC, the diagnostic yield of CCE, the therapeutic impact of lesions found in CCE, the level of colon cleanliness and the safety of the procedure. METHODS: We performed a prospective, multicenter study involving ten Spanish hospitals...
February 23, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28228691/overexpression-of-suppressor-of-zest-12-is-associated-with-cervical-node-metastasis-and-unfavorable-prognosis-in-tongue-squamous-cell-carcinoma
#9
Huijun Hu, Yi Wang, Zhongwu Li, Yumin Zhu, Wei Zhang, Dongmiao Wang, Tangyi Lin, Jianrong Yang, Yanling Wang, Jie Cheng
OBJECTIVE: Increased expression of suppressor of zest 12 (SUZ12), a core component of the polycomb repressive complex 2, contributes to human tumorigenesis and associates with patient prognosis. In the present study, we sought to investigate the expression of SUZ12 and its clinicopathological significance in primary tongue squamous cell carcinoma (TSCC). METHODS: The expression of SUZ12 protein was determined by immunohistochemistry in clinical samples from a retrospective cohort of 72 patients with primary TSCC who were treated at our institution from Jan...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28228139/hmga2-immunostaining-is-a-straightforward-technique-which-helps-to-distinguish-pulmonary-fat-forming-lesions-from-normal-adipose-tissue-in-small-biopsies-a-retrospective-observational-study-about-a-series-of-13-lung-biopsies
#10
Nicolas Piton, Émilie Angot, Florent Marguet, Jean-Christophe Sabourin
BACKGROUND: A tracheobronchial lesion observed during an endoscopic examination is usually sampled by the pulmonologist and sent to the pathologist for microscopic examination. Adipocytes may be observed in the lamina propria of tracheobronchial biopsies, which may complicate diagnosis of sampled lesions because these adipose cells may be part of the lesion (lipoma or pulmonary hamartoma), but may also be a normal component of the bronchial mucosa. Because endoscopic samples frequently miss their target, adipocytes observed in such biopsies usually lead to uncertainty regarding diagnosis...
February 23, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28228069/recent-advances-in-the-gastric-mucosal-protection-against-stress-induced-gastric-lesions-importance-of-renin-angiotensin-vasoactive-metabolites-gaseous-mediators-and-appetite-peptides
#11
Tomasz Brzozowski, Katarzyna Magierowska, Marcin Magierowski, Agata Ptak-Belowska, Robert Pajdo, Slawomir Kwiecien, Rafal Olszanecki, Ryszard Korbut
Stress is known to cause severe adverse effects in the human gastrointestinal tract including mucosal microbleedings and erosions or even gastric ulceration but the mechanism of these complications has not been fully elucidated. The pathogenesis of stress-induced gastric damage involves the fall in gastric blood flow (GBF), an increase in gastric acid secretion and gastric motility, enhanced adrenergic and cholinergic nerve activity and the rise in gastric mucosal generation of reactive oxygen species. The gastric mucosal defense mechanisms against the deleterious effect of stress include the activation of the hypothalamic-pituitary-adrenal axis which has been linked with glucocorticoids release capable of counteracting of stress-induced gastric lesions...
February 20, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28228068/stress-in-gastrointestinal-tract-and-stable-gastric-pentadecapeptide-bpc-157-finally-do-we-have-a-solution
#12
Predrag Sikiric, Sven Seiwerth, Rudolf Rucman, Domagoj Drmic, Mirjana Stupnisek, Antonio Kokot, Marko Sever, Ivan Zoricic, Zoran Zoricic, Lovorka Batelja, Tihomil Ziger, Josipa Vlainic, Zarko Rasic, Martina Lovric Bencic
Selye's syndrome produced by diverse nocuous agents and "response to damage as such" means Selye's stress triad in stress coping response to reestablish homeostasis. Logically, from the gastrointestinal tract viewpoint, such organoprotective/healing response implies the angiogenic growth factors that commonly signify the healing. Thereby, the gastric pentadecapeptide BPC 157-organoprotection (huge range of beneficial effects) signifies the Selye's stress concept/stress coping response implemented in and from gastrointestinal tract, and BPC 157 as an integrative mediator that integrates the adaptive bodily response to stress...
February 20, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28226980/gastric-mucosa-injury-quantification-in-an-ischemia-reperfusion-experimental-model
#13
E Pena-Mercado, M Garcia-Lorenzana, E Arechaga, C H Gonzalez-de la Rosa, N E Beltran, E Pena-Mercado, M Garcia-Lorenzana, E Arechaga, C H Gonzalez-de la Rosa, N E Beltran, E Arechaga, E Pena-Mercado, M Garcia Lorenzana, N E Beltran
Gastric ischemia - reperfusion (I/R) injury is an important clinical problem, which is developed in more than 80% of critically ill patients. I/R is caused by interruption of blood supply to an organ or tissue followed by blood reflow into the exposed area, leading to multiple organ failure and death. Gastric reactance has been proposed to measure tissue injury caused by ischemia. The present study evaluates a new method to quantify gastric tissue damage due to I/R, and assess its relation to gastric reactance changes...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226556/optimization-of-extra-corporeal-enteral-prosthesis-ecep-by-selective-aspiration-of-the-digestive-flow
#14
J R Nzamushe, J P Sozanski, J De Jonckheere, M Jeanne, R Logier, J R Nzamushe, J P Sozanski, J De Jonckheere, M Jeanne, R Logier, J R Nzamushe, J De Jonckheere, R Logier, M Jeanne, Jp Sozanski
Reinfusion is a medical process which collects digestive flow from a proximal stoma to a distal one, in patient who had a post-operative double enteral stoma. This process avoids the risk of under nutrition and frees the patient from a Total Parenteral Nutrition to offset the digestive loss. Most of the previous ways of reinfusion first collect the digestive flow into a bag before instillation. We developed an ambulatory reinfusion pump (ECEP) which had the advantage to collect the digestive flow directly from the proximal stoma and to pump it to the distal one...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226358/-laparoscopic-segmental-gastrectomy-for-early-gastric-cancer
#15
Lai Xu, Beizhan Niu, Xiyu Sun, Menghua Dai, Yi Xiao
OBJECTIVE: To investigate the feasibility of segmental pylorus-reservation gastrectomy in patients with early gastric cancer. METHOD: A retrospective cohort study on clinical data of 6 patients strictly met the criteria of early gastric cancer locating in the middle of the stomach undergoing laparoscopic segmental gastrectomy from January 2014 to April 2016 at Department of General Surgery, Peking Union Medical College Hospital was carried out. Preoperative clinical staging revealed T1N0M0 for all the cases...
February 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28225919/claudin-3-and-occludin-content-in-the-glands-of-colonic-mucosa-devoid-from-fecal-stream-submitted-to-topical-intervention-with-oil-extract-of-curcuma-longa
#16
Carlos Augusto Real Martinez, Caled Jaoudat Kadri, Danilo Toshio Kanno, Antônio José Tibúrcio Alves, Cláudio Saddy Rodrigues Coy, José Aires Pereira
Purpose: To evaluate the inflammatory intensity and measure the tissue content of the proteins claudin-3 and occludin in the colonic mucosa without fecal stream submit to intervention with curcumin. Methods: Thirty-six rats were submitted to a proximal colostomy and a distal mucous fistula and divided into two groups according to sacrifice to be performed two or four weeks. Each group was divided into three subgroups according daily application of enemas containing saline, curcumin at 50 mg/kg/day or 200 mg/kg/day...
January 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28225857/malignant-melanoma-with-synchronous-thyroid-metastases-case-report-and-literature-review
#17
Maria Manuel Costa, Sandra Belo, João Capela-Costa, Jennifer Costa, Davide Carvalho
Thyroid metastases are rare in clinical practice. We describe the case of an 85-year-old woman who was referred to our department due to a multinodular goiter with compressive symptoms and subclinical hyperthyroidism. The patient was also undergoing evaluation for a polyp in her left nasal cavity, which was then diagnosed as a malignant melanoma of the nasal mucosa. A thoracoabdominal magnetic resonance imaging obtained for cancer staging revealed a > 50% tracheal obstruction caused by the goiter. The patient underwent simultaneous total thyroidectomy and melanoma excision...
February 16, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28225318/endoscopic-tympanoplasty-in-the-treatment-of-chronic-otitis-media-our-experience
#18
Giuseppe Panetti, Matteo Cavaliere, Maria Panetti, Anna Marino, Maurizio Iemma
CONCLUSION: The endoscopy ensures good surgical exposure of hidden areas, frequently sites of residual cholesteatoma. Also, the minimally invasive endoscopic approach is more respectful of anatomy and functionality of the middle ear, restoring and preserving mastoid mucosa, with faster healing time. OBJECTIVES: To investigate the benefits that the systematic use of endoscopy in middle ear surgery has made. STUDY DESIGN: Retrospective cohort studies...
March 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28224429/slc38a1-promotes-proliferation-and-migration-of-human-colorectal-cancer-cells
#19
Fen-Fang Zhou, Wei Xie, Shuang-Qian Chen, Xiao-Kang Wang, Qing Liu, Xue-Kai Pan, Fei Su, Mao-Hui Feng
Current studies have demonstrated that SLC38A1 proteins play a causal role in neoplastic cell transformation. The twofold aim of this study was to provide insight into whether a variance in the expression of SLC38A1 exists between human colorectal cancer and healthy human tissues and to determine how silencing or overexpressing the SLC38A1 gene could affect the proliferation, viability and migration of colorectal cancer cells. Immunohistochemical staining was used to analyze the expression of SLC38A1 in colorectal cancer tissues and adjacent normal mucosa in 77 patients who underwent surgical resection...
February 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28224027/helicobacter-pylori-caga-induced-interleukin-8-secretion-in-gastric-epithelial-cells
#20
Zeinab Fazeli, Masoud Alebouyeh, Mostafa Rezaei Tavirani, Masoumeh Azimirad, Abbas Yadegar
AIM: Since, contradictory data have been reported about the effect of diverse variants of H. pylori virulence factors on IL-8 induction, we aimed to analyze the effect of this diversity on levels of IL-8 secretion in AGS cell line. BACKGROUND: Helicobacter pylori colonizes the human stomach and induces the activation of inflammatory cytokines, including interleukin (IL)-8, in the gastric mucosa. This induction promotes neutrophil and monocyte recruitment that causes gastric tissue damage...
December 2016: Gastroenterology and Hepatology From Bed to Bench
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