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https://www.readbyqxmd.com/read/29156831/protective-effect-of-nsa-on-intestinal-epithelial-cells-in-a-necroptosis-model
#1
Wei Dong, Min Zhang, Yaxi Zhu, Yuanhan Chen, Xingchen Zhao, Ruizhao Li, Li Zhang, Zhiming Ye, Xingling Liang
Objective: This study aimed to investigate the protective effect of the necroptosis inhibitor necrosulfonamide (NSA) on intestinal epithelial cells using a novel in vitro necroptosis model that mimics inflammatory bowel disease (IBD). Methods: 2,4,6-trinitrobenzenesulfonic acid (TNBS) was perfused into the rectum of BALB/c mice to established a colitis model. Pathologic injury and cell death were evaluated. A novel in vitro model of necroptosis was established in Caco-2 cells using TNF-α and Z-VAD-fmk, and the cells were treated with or without NSA...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156761/extracts-from-hericium-erinaceus-relieve-inflammatory-bowel-disease-by-regulating-immunity-and-gut-microbiota
#2
Chen Diling, Yang Xin, Zheng Chaoqun, Yang Jian, Tang Xiaocui, Chen Jun, Shuai Ou, Xie Yizhen
Hericium erinaceus (HE), a traditional edible mushroom, is known as a medicine food homology to ameliorate gastrointestinal diseases. To investigate whether HE is clinically effective in alleviating inflammatory bowel disease (IBD), HE extracts (polysaccharide, alcoholic extracts and whole extracts were prepared using solvent extraction methods) were administrated for 2 weeks in rats with IBD induced by trinitro-benzene-sulfonic acid (TNBS) enema (150 mg/kg). Significant clinical and histological changes in IBD rats were identified, including damage activity, common morphous and tissue damage index scores in colonic mucosa and myeloperoxidase (MPO) activity...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156524/kif3a-knockdown-sensitizes-bronchial-epithelia-to-apoptosis-and-aggravates-airway-inflammation-in-asthma
#3
Gang Geng, Ying Du, Jihong Dai, Daiyin Tian, Yunqiu Xia, Zhou Fu
BACKGROUND: KIF3A expression was decreased in asthmatic child patients and animal. Impaired KIF3A expression resulted in increased Th2 inflammation in mice and apoptosis in renal tubular epithelium and photoreceptor cells. This work aimed to investigate the role of KIF3A in epithelium apoptosis and bronchial inflammation in asthma. METHODS: After establishment of ovalbumin induced asthma, the mice were infected with KIF3A adenovirus through nasal cavity inhalation...
November 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29156514/esophageal-baseline-impedance-reflects-mucosal-integrity-and-predicts-symptomatic-outcome-with-proton-pump-inhibitor-treatment
#4
Chenxi Xie, Daniel Sifrim, Yuwen Li, Minhu Chen, Yinglian Xiao
Background/Aims: Esophageal baseline impedance, which is decreased in gastroesophageal reflux disease (GERD) patients, is related to the severity of acid reflux and the integrity of the esophageal mucosa. The study aims to compare the baseline impedance and the dilated intercellular spaces (DIS) within patients with typical reflux symptoms and to evaluate the correlation of baseline impedance with DIS, esophageal acid exposure, as well as the efficacy of proton pump inhibitor (PPI) treatment...
November 21, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/29156431/pathway-of-oxfendazole-from-the-host-into-the-worm-trichuris-suis-in-pigs
#5
Tina V A Hansen, Andrew R Williams, Matthew Denwood, Peter Nejsum, Stig M Thamsborg, Christian Friis
It is well known that the efficacy of a single oral dose of benzimidazoles against Trichuris spp. infections in humans and animals is poor, but is currently still used in control programmes against human trichuriasis. However, the route of the benzimidazoles from the treated host to Trichuris remains unknown. As parts of adult Trichuris are situated intracellularly in the caecum, they might be exposed to anthelmintic drugs in the intestinal content as well as the mucosa. In this study, the pathway of oxfendazole and its metabolites was explored using a T...
November 9, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29156298/european-research-on-electrochemotherapy-in-head-and-neck-cancer-eureca-project-results-from-the-treatment-of-mucosal-cancers
#6
Christina Caroline Plaschke, Giulia Bertino, James A McCaul, Juan J Grau, Remco de Bree, Gregor Sersa, Antonio Occhini, Ales Groselj, Cristobal Langdon, Derrek A Heuveling, Maja Cemazar, Primoz Strojan, C Rene Leemans, Marco Benazzo, Francesca De Terlizzi, Irene Wessel, Julie Gehl
AIM: Electrochemotherapy is an effective local treatment for cutaneous tumours and metastases. In this prospective trial, six European institutions investigated electrochemotherapy in recurrent, mucosal head and neck tumours. PATIENT AND METHODS: Forty-three patients with recurrent mucosal head and neck tumours and no further curative or reasonably effective palliative treatment options were enrolled and treated with electrochemotherapy. Patients were treated in general anaesthesia using intravenous or local injection of bleomycin followed by delivery of electric pulses to the tumour area...
November 16, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29155519/quantitative-changes-of-gastric-mucosa-during-carcinogenesis-using-stereological-methods
#7
Zahra Heidari, Hamidreza Mahmoudzadeh-Sagheb, Mahdieh Narouei
PURPOSE: To investigate the effects of helicobacter pylori (H. pylori) infection on the quantitative changes of gastric mucosa in cancerous and precancerous lesions using stereological methods. METHODS: One hundred and twenty-two gastric samples were studied. After determination of H. pylori infection, 42 gastric tissues of intestinal metaplasia (IM) patients, 38 specimens from dysplasia (DYS), and 42 specimens from gastric cancer (GC) types were selected from the pathology archive of Imam Ali Hospital, Zahedan, Iran...
July 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29155481/peroxisome-proliferator-activated-receptor-gamma-stimulation-for-prevention-of-5-fluorouracil-induced-oral-mucositis-in-mice
#8
Mariangela Sottili, Monica Mangoni, Chiara Gerini, Giulia Salvatore, Francesca Castiglione, Isacco Desideri, Pierluigi Bonomo, Icro Meattini, Daniela Greto, Mauro Loi, Giulio Francolini, Marco Perna, Roberta Grassi, Giampaolo Biti, Lorenzo Livi
BACKGROUND: Oral mucositis is a side effect of treatment regimens containing 5-fluorouracil (5-FU). The purpose of this study was to present our evaluation to see if rosiglitazone (RGZ) protected normal tissues from chemotherapy-induced oral mucositis. METHODS: C57BL/6J mice were treated with 5-FU for 5 days, with or without RGZ. Mice were euthanized after 5, 8, 11, or 15 days, and mucosal segments were collected. RESULTS: The RGZ did not affect the 5-FU-induced decrease in mouse body weight...
November 20, 2017: Head & Neck
https://www.readbyqxmd.com/read/29155272/oral-immunization-with-recombinant-lactobacillus-casei-expressing-ompai-confers-protection-against-aeromonas-veronii-challenge-in-common-carp-cyprinus-carpio
#9
Dong-Xing Zhang, Yuan-Huan Kang, Long Chen, Shahrood Ahmed Siddiqui, Chun-Feng Wang, Ai-Dong Qian, Xiao-Feng Shan
Aeromonas veronii is a gram-negative pathogen capable of infecting both fish and mammals, including humans, and natural infection in fish results in irreparable damage to the aquaculture industry. Lactic acid bacteria (LAB) have a number of properties that make them attractive candidates as delivery vehicles for presentation to the mucosa sites of compounds with pharmaceutical interest, in particular vaccines. In this study, we generated two recombinant Lactobacillus casei (surface-displayed or secretory) expressing the OmpAI of A...
November 16, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29155047/novel-mosaic-variants-in-two-patients-with-cornelia-de-lange-syndrome
#10
Jelena Pozojevic, Ilaria Parenti, Luitgard Graul-Neumann, Sara Ruiz Gil, Erwan Watrin, Kerstin S Wendt, Ralf Werner, Tim M Strom, Gabriele Gillessen-Kaesbach, Frank J Kaiser
Cornelia de Lange syndrome (CdLS) is a dominantly inherited developmental disorder caused by mutations in genes that encode for either structural (SMC1A, SMC3, RAD21) or regulatory (NIPBL, HDAC8) subunits of the cohesin complex. NIPBL represents the major gene of the syndrome and heterozygous mutations can be identified in more than 65% of patients. Interestingly, large portions of these variants were described as somatic mosaicism and often escape standard molecular diagnostics using lymphocyte DNA. Here we discuss the role of somatic mosaicism in CdLS and describe two additional patients with NIPBL mosaicism detected by targeted gene panel or exome sequencing...
November 15, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29154866/activation-of-igf-1-igfbp-3-signaling-by-berberine-improves-intestinal-mucosal-barrier-of-rats-with-acute-endotoxemia
#11
Yan He, Xiaoming Yuan, Guangrong Zhou, Aiwen Feng
Insulin-like growth factor I (IGF-I) and binding protein 3 (IGFBP-3) play a role in the maintenance of gut mucosal barrier function. Nevertheless, IGF-I/IGFBP-3 and tight junction protein (TJP) expression in small intestinal mucosa are often impaired during endotoxemia. In this model of acute endotoxemia, the regulatory effect of berberine on IGF-I/IGFBP-3 and TJP expression in ileal mucosa was evaluated. The findings revealed systemic injection of lipopolysaccharide (LPS) suppressed mRNA and protein expression of IGF-I and IGFBP-3, but berberine ameliorated their production...
November 14, 2017: Fitoterapia
https://www.readbyqxmd.com/read/29154844/anticoccidial-effects-of-areca-nut-areca-catechu-l-extract-on-broiler-chicks-experimentally-infected-with-eimeria-tenella
#12
Dingfa Wang, Luli Zhou, Wei Li, Hanlin Zhou, Guanyu Hou
To study the anticoccidial effects of areca nut extract (ANE) on coccidiosis, 270 one-day old Wenchang broiler chicks were divided into six equal groups, each with three replicate cages (n = 15 per cage). The six groups were the blank control group (BC), negative control group (NC), positive control group (PC), and three ANE-treated groups. The birds in the three control groups (BC, NC and PC) were fed a basal diet without ANE supplementation. The birds in the three ANE-treated groups were fed a basal diet supplied with ANE at 100 (T1), 200 (T2), or 300 (T3) mg/kg feed...
November 14, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/29154086/mechanical-characterization-of-in-vitro-formed-short-term-salivary-pellicle
#13
Yafeng Zhang, Jing Zheng, Jiaxin Yu, Hongtu He
Human saliva consists of approximately 98% water and a variety of electrolytes and proteins. Those proteins can be selectively adsorbed onto the enamel surface. The cuticular material formed on the enamel surface is termed acquired salivary pellicle (ASP), which is critical for the health of oral mucosa and teeth. The ASP is composed of a inner layer and a outer layer. The lubricating properties of ASP are closely associated with the inner layer. The aim of this research is to characterize the structural and mechanical properties of the inner layer of ASP...
November 7, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29153543/-aspirin-and-colorectal-cancer
#14
REVIEW
Adrien Grancher, Pierre Michel, Frédéric Di Fiore, David Sefrioui
Colorectal cancer is a worldwide public health problem. Aspirin has been identified as a protective factor against the apparition of colorectal cancer. There are several mechanisms about the actions by aspirin on colorectal tumorogenesis. These are not perfectly known nowadays. On one hand, there are direct mechanisms on colorectal mucosa, on the other hand there are indirect mechanisms through platelet functions. Aspirin also plays a role by its anti-inflammatory action and the stimulation of antitumor immunity...
November 15, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29153035/an-unusual-presentation-of-pseudocowpox-associated-with-an-outbreak-of-pustular-ulcerative-vulvovaginitis-in-a-swedish-dairy-herd
#15
Gunilla Blomqvist, Karin Ullman, Thomas Segall, Elenor Hauzenberger, Lena Renström, Karin Persson-Waller, Mikael Leijon, Jean-Francois Valarcher
Species Pseudocowpox virus (PCPV; family Poxviridae) is known to cause pustular cutaneous disease in cattle. We describe an outbreak of pseudocowpox with an unusual clinical picture in a free-stall dairy herd of ~80 cows. Approximately 90% of the cows had vesicles, erosions, papules, and scabs on the vulva and vaginal mucosa. Histologic analysis of biopsy tissues indicated a primary, although not specified, viral infection. Transmission electron microscopy revealed parapoxvirus particles in both tissue and vesicular materials...
November 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29152793/effects-of-dietary-tryptophan-levels-on-performance-and-biochemical-variables-of-plasma-and-intestinal-mucosa-in-yellow-feathered-broiler-breeders
#16
S Q Jiang, Z Y Gou, X J Lin, L Li
The effects of dietary tryptophan (Trp) levels on performance and biochemical variables of plasma and intestinal mucosa in broiler breeder hens were investigated in this study. A total of 780 Lingnan yellow-feathered broiler breeder hens were randomly assigned in one of five dietary treatments with six replicates per treatment (26 birds per replicate). The breeder hens were fed either the basal diet (0.11% Trp) or the basal diet supplemented to 0.15%, 0.19%, 0.23% and 0.27% Trp, from 197 to 259 days of age...
November 19, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29152749/effect-of-topical-nasal-anesthetic-on-swallowing-in-healthy-adults-a-double-blind-high-resolution-manometry-study
#17
Esther Guiu Hernandez, Kristin Gozdzikowska, Olivia Apperley, Maggie-Lee Huckabee
OBJECTIVE: Topical nasal anesthetic (TNA) is used when evaluating pharyngeal swallowing with high-resolution manometry (HRM). It is unclear if desensitizing the nasal mucosa improves procedure tolerability or affects pharyngeal pressure. This study evaluated the effects of TNA on comfort and pharyngeal pressure using HRM. METHODS: A double-blinded study was conducted with 20 healthy participants ( x¯ = 27 years). Participants performed five saliva and five 10-mL swallows during two exams with ManoScan HRM ESO catheter (Medtronic, Minneapolis, MN) randomized under placebo (nonanesthetic lubricant) and anesthetized (0...
November 20, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29152700/the-micronucleus-test-for-the-oral-mucosa-global-trends-and-new-questions
#18
Marcelino Benvindo-Souza, Rhayane Alves Assis, Eliane Andreia Santos Oliveira, Rinneu Elias Borges, Lia Raquel de Souza Santos
This study reviews global trends in the publication of papers on the micronucleus test of the exfoliated cells of the oral mucosa in mammals as an approach for environmental biomonitoring. This test has been widely used due to its precision for the detection of chromosome damage. Our temporal analysis showed a significant increase (p < 0.05) in the publication of papers on the oral mucosa over the past 33 years. Brazil was the country that published most papers (24% of the total), followed by India (16%), the USA (10%), Mexico (7%), and Turkey (6%)...
November 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29152066/identification-and-validation-of-fgfr2-peptide-for-detection-of-early-barrett-s-neoplasia
#19
Juan Zhou, Lei He, Zhijun Pang, Henry D Appelman, Rork Kuick, David G Beer, Meng Li, Thomas D Wang
The incidence of esophageal adenocarcinoma (EAC) is rising rapidly, and early detection within the precursor state of Barrett's esophagus (BE) is challenged by flat premalignant lesions that are difficult detect with conventional endoscopic surveillance. Overexpression of cell surface fibroblast growth factor receptor 2 (FGFR2) is an early event in progression of BE to EAC, and is a promising imaging target. We used phage display to identify the peptide SRRPASFRTARE that binds specifically to the extracellular domain of FGFR2...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29151525/achromobacter-infection-is-rare-in-japanese-patients-with-pulmonary-b-cell-lymphoma
#20
Satsuki Aoyama, Ayako Masaki, Yuma Sakamoto, Hisashi Takino, Takayuki Murase, Koichi Ohshima, Tadashi Yoshino, Seiichi Kato, Hiroshi Inagaki
Objective Achromobacter xylosoxidans (A. xylosoxidans) has been recently reported to have an association with the development of pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma in patients from European countries. However, the prevalence rates for A. xylosoxidans may vary significantly from country to country. To assess this association, the prevalence of A. xylosoxidans was analyzed in Japanese patients with pulmonary B-cell lymphoma. Methods DNA samples were obtained from formalin-fixed, paraffin-embedded sections of pulmonary MALT lymphomas (n=52), diffuse large B-cell lymphomas (DLBCLs, n=18), and benign pulmonary lesions (n=19)...
November 20, 2017: Internal Medicine
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