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https://www.readbyqxmd.com/read/28739310/identification-of-new-tsga10-transcript-variants-in-human-testis-with-conserved-regulatory-rna-elements-in-5-untranslated-region-and-distinct-expression-in-breast-cancer
#1
Pouya Salehipour, Mahsa Nematzadeh, Maryam Beigom Mobasheri, Mandana Afsharpad, Mohammad Hossein Modarressi
Testis specific gene antigen 10 (TSGA10) is a cancer testis antigen involved in the process of spermatogenesis. TSGA10 could also play an important role in the inhibition of angiogenesis by preventing nuclear localization of HIF-1α. Although it has been shown that TSGA10 messenger RNA (mRNA) is mainly expressed in testis and some tumors, the transcription pattern and regulatory mechanisms of this gene remain largely unknown. Here, we report that human TSGA10 comprises at least 22 exons and generates four different transcript variants...
July 21, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28738012/evaluation-of-protein-kinase-ck2-as-a-therapeutic-target-for-squamous-cell-carcinoma-of-cats
#2
Claire M Cannon, Janeen H Trembley, Betsy T Kren, Gretchen M Unger, M Gerard O'Sullivan, Ingrid Cornax, Jaime F Modiano, Khalil Ahmed
OBJECTIVE To investigate protein kinase CK2 (CK2) expression in squamous cell carcinoma (SCC) of cats and to examine effects of CK2 downregulation on in vitro apoptosis and viability in SCC. SAMPLE Biopsy specimens of oral mucosa and testis and blood samples from clinically normal cats, biopsy specimens of oral SCC from cats, and feline SCC (SCCF1) and mammary gland carcinoma (K12) cell lines. PROCEDURES Immunohistochemical labeling for CK2α was performed on biopsy specimens. Sequences of the CK2α subunit gene and CK2α' subunit gene in feline blood and feline cancer cell lines were determined by use of PCR and reverse-transcription PCR assays followed by direct Sanger sequencing...
August 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28735890/prognostic-validation-of-sky92-and-its-combination-with-iss-in-an-independent-cohort-of-patients-with-multiple-myeloma
#3
Erik H van Beers, Martin H van Vliet, Rowan Kuiper, Leonie de Best, Kenneth C Anderson, Ajai Chari, Sundar Jagannath, Andrzej Jakubowiak, Shaji K Kumar, Joan B Levy, Daniel Auclair, Sagar Lonial, Donna Reece, Paul Richardson, David S Siegel, A Keith Stewart, Suzanne Trudel, Ravi Vij, Todd M Zimmerman, Rafael Fonseca
BACKGROUND: High risk and low risk multiple myeloma patients follow a very different clinical course as reflected in their PFS and OS. To be clinically useful, methodologies used to identify high and low risk disease must be validated in representative independent clinical data and available so that patients can be managed appropriately. A recent analysis has indicated that SKY92 combined with the International Staging System (ISS) identifies patients with different risk disease with high sensitivity...
July 4, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28729426/glycerol-3-phosphate-acyltransferase-2-is-essential-for-normal-spermatogenesis
#4
Maria Belen Garcia-Fabiani, Mauro A Montanaro, Pablo Stringa, Ezequiel Lacunza, Elizabeth R Cattaneo, Marianela Santana, Magali Pellon-Maison, Maria R Gonzalez-Baro
Glycerol-3-phosphate acyltransferases (GPAT) catalyze the first and rate-limiting step in the de novo glycerolipid synthesis. The GPAT2 isoform differs from the other isoforms because its expression is restricted to male germ cells and cancer cells. It has been recently reported that GPAT2 expression in mouse testis fluctuates during sexual maturation and that it is regulated by epigenetic mechanisms in combination with vitamin A derivatives. Despite progress made in this field, information about GPAT2 role in the developing male germ cells remains unclear...
July 20, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28726031/the-natural-history-of-leydig-cell-testicular-tumours-an-analysis-of-the-national-cancer-registry
#5
G J Nason, E J Redmond, S W Considine, S I Omer, D Power, P Sweeney
BACKGROUND: Leydig cell tumour (LCT) of the testis is a rare histological subtype of stromal tumours, accounting for 1 to 3% of testicular neoplasms. The natural history of LCT is poorly understood. AIMS: The aim of this study was to assess the incidence and natural history of Leydig cell tumours (LCT) of the testes. METHODS: A search of the National Cancer Registry of Ireland database was performed regarding Leydig cell testicular tumours...
July 19, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28716148/prevalence-of-plasma-autoantibody-against-cancer-testis-antigen-ny-eso-1-in-htlv-1-infected-individuals-with-different-clinical-status
#6
Yasuo Shiohama, Tadasuke Naito, Toshio Matsuzaki, Reiko Tanaka, Takeaki Tomoyose, Hiroshi Takashima, Takuya Fukushima, Yuetsu Tanaka, Mineki Saito
BACKGROUND: Detection of specific immune responses against cancer/testis antigen NY-ESO-1 was recently reported in patients with adult T-cell leukemia/lymphoma (ATL) and human T-cell leukemia virus type 1 (HTLV-1)-infected asymptomatic carriers (ACs). However, the relationship of the responses with the HTLV-1 proviral load (PVL) and the levels of viral gene expression remain unclear. FINDINGS: We measured plasma levels of autoantibodies to NY-ESO-1 immunogenic tumor antigen in HTLV-1-infected individuals with different clinical status, and in healthy controls...
July 17, 2017: Virology Journal
https://www.readbyqxmd.com/read/28716051/mir-380-5p-mediated-repression-of-tep1-and-tspyl5-interferes-with-telomerase-activity-and-favours-the-emergence-of-an-alt-like-phenotype-in-diffuse-malignant-peritoneal-mesothelioma-cells
#7
Graziella Cimino-Reale, Paolo Gandellini, Francesca Santambrogio, Marta Recagni, Nadia Zaffaroni, Marco Folini
BACKGROUND: Understanding the molecular/cellular underpinnings of diffuse malignant peritoneal mesothelioma (DMPM), a fatal malignancy with limited therapeutic options, is of utmost importance for the fruitful management of the disease. In this context, we previously found that telomerase activity (TA), which accounts for the limitless proliferative potential of cancer cells, is prognostic for disease relapse and cancer-related death in DMPM patients. Consequently, the identification of factors involved in telomerase activation/regulation may pave the way towards the development of novel therapeutic interventions for the disease...
July 17, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28710511/cerebellar-degeneration-related-proteins-2-and-2-like-are-present-in-ovarian-cancer-in-patients-with-and-without-yo-antibodies
#8
Margrethe Raspotnig, Mette Haugen, Maria Thorsteinsdottir, Ingunn Stefansson, Helga B Salvesen, Anette Storstein, Christian A Vedeler
BACKGROUND: Cerebellar degeneration-related protein 2 (CDR2) has been presumed to be the main antigen for the onconeural antibody Yo, which is strongly associated with ovarian cancer and paraneoplastic cerebellar degeneration (PCD). Recent data show that Yo antibodies also target the CDR2-like protein (CDR2L). We, therefore, examined the expression of CDR2 and CDR2L in ovarian cancer tissue from patients with and without Yo antibodies and from various other cancerous and normal human tissues...
July 14, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28707023/oxidative-inactivation-of-the-endogenous-antioxidant-protein-dj-1-by-the-food-contaminants-3-mcpd-and-2-mcpd
#9
Thorsten Buhrke, Linn Voss, Anja Briese, Heike Stephanowitz, Eberhard Krause, Albert Braeuning, Alfonso Lampen
3-Chloro-1,2-propanediol (3-MCPD) and 2-chloro-1,3-propanediol (2-MCPD) are heat-induced food contaminants being present either as free substances or as fatty acid esters in numerous foods. 3-MCPD was classified to be possibly carcinogenic to humans (category 2B) with kidney and testis being the primary target organs according to animal studies. A previous 28-day oral feeding study with rats revealed that the endogenous antioxidant protein DJ-1 was strongly deregulated at the protein level in kidney, liver, and testis of the experimental animals that had been treated either with 3-MCPD, 2-MCPD or their dipalmitate esters...
July 13, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28701892/a-pilot-study-of-post-operative-adjuvant-vaccine-for-advanced-gastric-cancer
#10
Yoshiyuki Fujiwara, Keijiro Sugimura, Hiroshi Miyata, Takeshi Omori, Hiroyuki Nakano, Chie Mochizuki, Katsuji Shimizu, Hiroaki Saito, Keigo Ashida, Soichiro Honjyo, Yusuke Nakamura, Masahiko Yano
BACKGROUND: Previously, we had performed a clinical study using human leukocyte antigen (HLA)-A24-binding peptide vaccines containing a combination of novel cancer-testis antigens and anti-angiogenic peptides derived from DEPDC1, URLC10, FOXM1, KIF20A and VEGFR1 for advanced gastric cancer (AGC) patients who were refractory to chemotherapy. We applied the cocktail vaccine to the combination therapy with S-1 for patients with AGC as a post-operative adjuvant therapy and performed this clinical pilot study...
June 2017: Yonago Acta Medica
https://www.readbyqxmd.com/read/28699894/cancer-testis-antigen-piwil2-suppresses-circadian-rhythms-by-regulating-the-stability-and-activity-of-bmal1-and-clock
#11
Yilu Lu, Xulei Zheng, Wei Hu, Shasha Bian, Zhiwei Zhang, Dachang Tao, Yunqiang Liu, Yongxin Ma
Circadian rhythms are regulated by transcriptional and post-translational feedback loops generated by appropriate functions of clock proteins. Rhythmic degradation of the circadian clock proteins is critical for maintenance of the circadian oscillations. Notably, circadian clock does not work during spermatogenesis and can be disrupted in tumors. However, the underlying mechanism that suppresses circadian rhythms in germ cells and cancer cells remains largely unknown. Here we report that the cancer/testis antigen PIWIL2 can repress circadian rhythms both in the testis and cancer cells...
July 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28698791/first-reported-case-of-paratesticular-seminoma-in-a-postpubertal-cryptorchid-testis
#12
Imad Elhajjar, Khalid Sayyid, Anas Mugharbil, Houssam Khodor Abtar
Cryptorchidism is a very common anomaly, affecting 2-4% of male infants and is more common in premature infants. The long-term outcome despite orchidopexy still remains problematic and controversial with a risk of developing cancer 5-10 times greater than normal. Paratesticular tumors are mostly benign and very rare in children however malignant paratesticular tumors do arise, the most common being rhabdomyosarcoma. Primary paratesticular seminoma is extremely rare by itself and in most cases is associated with foci of seminoma within the testis...
June 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28687143/contemporary-treatment-patterns-and-outcomes-for-clinical-stage-is-testicular-cancer
#13
Sophia C Kamran, Thomas Seisen, Sarah C Markt, Mark A Preston, Quoc-Dien Trinh, Lindsay A Frazier, Toni K Choueiri, Neil E Martin, Paul L Nguyen, Clair J Beard
BACKGROUND: Controversy exists regarding the optimal management strategy for clinical stage IS seminomatous (SGCT) and nonseminomatous germ cell tumors (NSGCT) of the testis. OBJECTIVE: To assess contemporary treatment patterns and outcomes for clinical stage IS testicular cancer. DESIGN, SETTING, AND PARTICIPANTS: Using the National Cancer Data Base (2004-2012), we identified 1362 patients with clinical stage IS SGCT and NSGCT of the testis, treated with either adjuvant treatment (AT) or observation...
July 4, 2017: European Urology
https://www.readbyqxmd.com/read/28679192/a-case-of-highly-aggressive-anaplastic-seminoma-of-the-testis-presenting-as-fungating-scrotal-lesion
#14
Massimiliano Creta, Vincenzo Mirone, Sergio Di Meo, Roberto Buonopane, Nicola Longo, Ferdinando Fusco, Nicola Rosario Forte, Vittorio Imperatore
Anaplastic seminoma (AS) is an uncommon histological variant of classical seminoma of the testis and account for 5%-15% of cases. It is poorly described in the scientific literature. We present the case of a 50-years-old homeless man presenting with fever, marked left scrotal hardness and a fungating left scrotal lesion. He underwent left orchiopexy 40 years before. A computed tomography with contrast media showed a suspect testis cancer with scrotal involvment, extensive intralesional necrosis and multiple systemic metastases...
June 30, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28670489/heat-shock-protein-70-2-hsp70-2-a-novel-cancer-testis-antigen-that-promotes-growth-of-ovarian-cancer
#15
Namita Gupta, Nirmala Jagadish, Avadhesha Surolia, Anil Suri
Heat shock protein 70-2 (HSP70-2) is known to be involved in tumor progression. However, its molecular role and mechanism in epithelial ovarian cancer (EOC) remains unknown. In the present investigation, we examined the role of HSP70-2 in cell cycle, apoptosis and epithelial mesenchymal transition pathways in EOC cells in in vitro and in-vivo xenograft mouse model. To investigate the role of HSP70-2 in ovarian cancer, plasmid driven short hairpin RNA approach was used to examine HSP70-2 gene and protein expression in ovarian cancer cell line A-10 (origin: serous papillary cystadenocarcinoma), Caov-3 (origin: adenocarcinoma) and SKOV3 (origin: adenocarcinoma; derived from metastatic site: ascites) by RT-PCR, quantitative-PCR, immunohistochemistry and Western blotting...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28670187/nuclear-protein-in-testis-midline-carcinoma-presenting-in-an-infant-as-a-pericardial-mass-with-staging-by-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#16
Crystal Perkins, Darko Pucar, Colleen H McDonough, Hadyn T Williams
Nuclear protein in testis (NUT) midline carcinoma (NMC) is a rare, aggressive, lethal, epithelioid, poorly differentiated cancer first described in Japan in 1991, unique in that is defined genetically rather than by histological tissue of origin. It usually arises in the body midline and presents as a mass with metastasis. An infant presenting with pneumonia was found to have a pericardial mass, NMC resected, and subsequent staging positron emission tomography (PET) showing residual mediastinal tumor and midline abdominal metastases...
July 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28668617/atorvastatin-mitigates-testicular-injuries-induced-by-ionizing-radiation-in-mice
#17
Ramezan Ali Naeimi, Fereshteh Talebpour Amiri, Ali Reza Khalatbary, Arash Ghasemi, Mehryar Zargari, Maryam Ghesemi, Seyed Jalal Hosseinimehr
BACKGROUND: Radiotherapy in patients with pelvis malignancy causes testes irradiation and resulted in testicular damages. Atorvastatin (ATV) in the low-dose is considered as antioxidant and anti-inflammatory properties. OBJECTIVE: This experimental study was investigated protective effects of ATV on irradiation-induced testicular injury. MATERIAL AND METHODS: Sixty male balb/c mice were randomly divided into 6 groups: 1: control, 2: irradiated (IR), 3, 4 and 5: IR plus ATV (10, 20 and 50mg/kg), 6: only ATV (50mg/kg)...
June 28, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28658877/bilateral-testicular-metastases-from-occult-primary-prostate-cancer-in-a-young-adult-a-rare-case-report
#18
Vijaya Rajesh Kamble, Purva Mahesh Agrawal
Testicular metastases are detected incidentally in upto 4% cases after orchiectomy for Prostate Carcinoma (PCa). Most of the secondaries to testes are due to PCa, only few patients have clinically manifested metastases to bilateral testes. Metastases to bilateral testis is unusual while unilateral involvement of the testis is seen usually. We report a case of primary PCa with bilateral testicular metastases which presented with palpable mass in the right testis. A 43-year-old male patient presented with two-month history of swelling in right inguino-scrotal region...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28656507/the-stem-cell-factor-scf-c-kit-signalling-in-testis-and-prostate-cancer
#19
Henrique J Cardoso, Marília I Figueira, Sílvia Socorro
The stem cell factor (SCF) is a cytokine that specifically binds the tyrosine kinase receptor c-KIT. The SCF/c-KIT interaction leads to receptor dimerization, activation of kinase activity and initiation of several signal transduction pathways that control cell proliferation, apoptosis, differentiation and migration in several tissues. The activity of SCF/c-KIT system is linked with the phosphatidylinositol 3-kinase (PI3-K), the Src, the Janus kinase/signal transducers and activators of transcription (JAK/STAT), the phospholipase-C (PLC-γ) and the mitogen-activated protein kinase (MAPK) pathways...
June 27, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28654092/risk-factors-for-cryptorchidism
#20
REVIEW
Jason K Gurney, Katherine A McGlynn, James Stanley, Tony Merriman, Virginia Signal, Caroline Shaw, Richard Edwards, Lorenzo Richiardi, John Hutson, Diana Sarfati
Undescended testis - known as cryptorchidism - is one of the most common congenital abnormalities observed in boys, and is one of the few known risk factors for testicular cancer. The key factors that contribute to the occurrence of cryptorchidism remain elusive. Testicular descent is thought to occur during two hormonally-controlled phases in fetal development - between 8-15 weeks (the first phase of decent) and 25-35 weeks gestation (the second phase of descent); the failure of a testis to descend permanently is probably caused by disruptions to one or both of these phases, but the causes and mechanisms of such disruptions are still unclear...
June 27, 2017: Nature Reviews. Urology
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