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https://www.readbyqxmd.com/read/27717794/disease-patterns-in-late-onset-ulcerative-colitis-results-from-the-ig-ibd-aged-study
#1
Walter Fries, Anna Viola, Natalia Manetti, Iris Frankovic, Daniela Pugliese, Rita Monterubbianesi, Giuseppe Scalisi, Annalisa Aratari, Laura Cantoro, Maria Cappello, Leonardo Samperi, Simone Saibeni, Giovanni Casella, Giammarco Mocci, Matilde Rea, Federica Furfaro, Antonella Contaldo, Andrea Magarotto, Francesca Calella, Francesco Manguso, Gaetano Inserra, Antonino C Privitera, Mariabeatrice Principi, Fabiana Castiglione, Flavio Caprioli, Sandro Ardizzone, Silvio Danese, Claudio Papi, Fabrizio Bossa, Anna Kohn, Alessandro Armuzzi, Renata D'Incà, Vito Annese, Angela Alibrandi, Stefanos Bonovas, Gionata Fiorino
BACKGROUND: Late-onset UC represents an important issue for the near future, but its outcomes and relative therapeutic strategies are yet poorly studied. AIM: To better define the natural history of late-onset ulcerative colitis. METHODS: In a multicenter retrospective study, we investigated the disease presentation and course in the first 3 years in 1091 UC patients divided into 3 age-groups: diagnosis ≥65years, 40-64 years, and <40years...
September 21, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/26933032/inflammatory-bowel-disease-phenotype-as-risk-factor-for-cancer-in-a-prospective-multicentre-nested-case-control-ig-ibd-study
#2
Livia Biancone, Alessandro Armuzzi, Maria Lia Scribano, Renata D'Inca, Fabiana Castiglione, Claudio Papi, Erika Angelucci, Marco Daperno, Filippo Mocciaro, Gabriele Riegler, Walter Fries, Gianmichele Meucci, Patrizia Alvisi, Luisa Spina, Sandro Ardizzone, Carmelina Petruzziello, Alessandra Ruffa, Anna Kohn, Maurizio Vecchi, Luisa Guidi, Roberto Di Mitri, Sara Renna, Calabrese Emma, Francesca Rogai, Alessandra Rossi, Ambrogio Orlando, Francesco Pallone
BACKGROUND AND AIMS: Cancer risk in inflammatory bowel disease [IBD] is still debated. In a prospective, multicentre, nested case-control study, we aimed to characterise incident cases of cancer in IBD. The role of immunomodulators vs clinical characteristics of IBD as risk factors for cancer was also investigated. MATERIALS AND METHODS: From January 2012 to December 2014, each IBD patient with incident cancer was matched with two IBD patients without cancer for: IBD type, gender, and age...
August 2016: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/26365596/the-spectrum-of-neutrophilic-dermatoses-associated-with-monoclonal-gammopathy-association-with-iga-isotype-and-inflammatory-profile
#3
REVIEW
Raphael Szalat, Gentiane Monsel, Wilfried Le Goff, Maxime Battistella, Djaouida Bengouffa, Marie-Helene Schlageter, Jean-David Bouaziz, Bertrand Arnulf, Marguerite Vignon, Philippe Lesnik, Anne Saussine, Marion Malphettes, Anne Lazareth, Marie-Dominique Vignon-Pennamen, Martine Bagot, Jean-Claude Brouet, Jean-Paul Fermand, Michel Rybojad, Bouchra Asli
BACKGROUND: Neutrophilic dermatoses refer to a group of cutaneous inflammatory disorders characterized by neutrophilic infiltration of the skin. Neutrophilic dermatoses have been reported in association with various conditions including autoimmune diseases, inflammatory bowel diseases, and neoplasia. In the later condition, myeloproliferative disorders and monoclonal gammopathy (monoclonal immunoglobulin [MIg]) are the most frequent. Only few data are available in case of neutrophilic dermatoses associated with MIg regarding the pathophysiology and the clinical outcome...
November 2015: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/26273818/pancreatic-autoantibodies-against-cuzd1-and-gp2-are-associated-with-distinct-clinical-phenotypes-of-crohn-s-disease
#4
Maike Anna Michaels, Sebastian Torben Jendrek, Tobias Korf, Thomas Nitzsche, Bianca Teegen, Lars Komorowski, Stefanie Derer, Torsten Schröder, Florian Baer, Henrik Lehnert, Jürgen Büning, Klaus Fellerman, Christian Sina
BACKGROUND: Inflammatory bowel disease (IBD) is characterized by a broad spectrum of clinical phenotypes with different outcomes. In the last decades, several IBD-associated autoantibodies have been identified and investigated for their diagnostic relevance. Autoantibodies against the pancreatic glycoproteins (PAB) CUB and zona pellucida-like domains-containing protein 1 (CUZD1), and glycoprotein 2 (GP2) have been demonstrated to possess high specificity for the diagnosis of IBD. Although several studies have shown significant interrelations of anti-GP2 positivity with disease phenotype, associations of clinical phenotypes with anti-CUZD1 are still unknown...
December 2015: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/26221895/efficacy-of-subcutaneous-immunoglobulins-in-primary-immunodeficiency-with-crohn-s-like-phenotype-report-of-a-case
#5
M Sanges, G Spadaro, M Miniero, D Mattera, R Sollazzo, F P D'Armiento, G D De Palma, A Pecoraro, F Borrelli, A Genovese, A D'Arienzo
Common variable immune deficiency (CVID) is the most frequent primary immunodeficiency in adults. In CVID, the prevalence of gastrointestinal manifestations ranges between 2 and 50% with a complication-related morbidity second only to that of the respiratory tract. In some cases, clinical and endoscopic features are undistinguishable from those of inflammatory bowel disease (IBD). We describe the case of a 28-year-old man in which a diagnosis of Crohn's disease was firstly suspected. Subsequently, a diagnosis of Crohn's-like disease in a patient with CVID was made and a replacement therapy with human normal immunoglobulin intravenously was started...
2015: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/26195794/protein-tyrosine-phosphatase-sap-1-protects-against-colitis-through-regulation-of-ceacam20-in-the-intestinal-epithelium
#6
Yoji Murata, Takenori Kotani, Yana Supriatna, Yasuaki Kitamura, Shinya Imada, Kohichi Kawahara, Miki Nishio, Edwin Widyanto Daniwijaya, Hisanobu Sadakata, Shinya Kusakari, Munemasa Mori, Yoshitake Kanazawa, Yasuyuki Saito, Katsuya Okawa, Mariko Takeda-Morishita, Hideki Okazawa, Hiroshi Ohnishi, Takeshi Azuma, Akira Suzuki, Takashi Matozaki
Intestinal epithelial cells contribute to regulation of intestinal immunity in mammals, but the detailed molecular mechanisms of such regulation have remained largely unknown. Stomach-cancer-associated protein tyrosine phosphatase 1 (SAP-1, also known as PTPRH) is a receptor-type protein tyrosine phosphatase that is localized specifically at microvilli of the brush border in gastrointestinal epithelial cells. Here we show that SAP-1 ablation in interleukin (IL)-10-deficient mice, a model of inflammatory bowel disease, resulted in a marked increase in the severity of colitis in association with up-regulation of mRNAs for various cytokines and chemokines in the colon...
August 4, 2015: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26182902/do-orally-administered-immunoglobulin-based-agents-represent-the-future-of-ibd-therapeutics
#7
EDITORIAL
Jason M Shapiro, Basavaraj Kerur
No abstract text is available yet for this article.
November 2015: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/26181108/ige-antibodies-and-skin-tests-in-immediate-hypersensitivity-reactions-to-infliximab-in-inflammatory-bowel-disease-impact-on-infliximab-retreatment
#8
Estelle Fréling, Laurent Peyrin-Biroulet, Claire Poreaux, Alain Morali, Julie Waton, Jean-Luc Schmutz, Jean-Louis Guéant, Annick Barbaud
BACKGROUND: Infliximab (IFX) is used for the treatment of inflammatory bowel diseases (IBD). Immediate hypersensitivity reactions (HR) to IFX are frequently reported. OBJECTIVES: We investigated immunoglobulin E (IgE)-mediated mechanisms underlying immediate HR to IFX. We also evaluated the clinical utility of allergological tests as well as the tolerability of IFX retreatment in these patients. METHODS: This was a prospective single-center study including IBD patients with previous immediate HR to IFX...
October 2015: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/26170138/proteolytic-cleavage-and-loss-of-function-of-biologic-agents-that-neutralize-tumor-necrosis-factor-in-the-mucosa-of-patients-with-inflammatory-bowel-disease
#9
Paolo Biancheri, Randall J Brezski, Antonio Di Sabatino, Allison R Greenplate, Keri L Soring, Gino R Corazza, Klaartje B Kok, Laura Rovedatti, Anna Vossenkämper, Nadja Ahmad, Susanne A Snoek, Severine Vermeire, Paul Rutgeerts, Robert E Jordan, Thomas T MacDonald
BACKGROUND & AIMS: Many patients with inflammatory bowel disease (IBD) fail to respond to anti-tumor necrosis factor (TNF) agents such as infliximab and adalimumab, and etanercept is not effective for treatment of Crohn's disease. Activated matrix metalloproteinase 3 (MMP3) and MMP12, which are increased in inflamed mucosa of patients with IBD, have a wide range of substrates, including IgG1. TNF-neutralizing agents act in inflamed tissues; we investigated the effects of MMP3, MMP12, and mucosal proteins from IBD patients on these drugs...
November 2015: Gastroenterology
https://www.readbyqxmd.com/read/26089697/differential-response-to-microbial-antigens-by-age-of-diagnosis-in-patients-with-crohn-s-disease
#10
Sandra M Quezada, Ankur Rustgi, Guruprasad D Jambaulikar, Raymond K Cross
PURPOSE: Fifteen percent of incident Crohn's disease (CD) cases are diagnosed at older ages and demonstrate colonic location and inflammatory behavior. Serologic responses to gut microbial antigens are associated with specific phenotypes, and may differ by age at diagnosis. Our aim was to identify an association between age at diagnosis of CD and responses to gut microbial antigens. PATIENTS AND METHODS: Levels of anti-Saccharomyces cerevisiae antibodies (ASCA) immunoglobulins A and G (IgA and IgG), antibodies to Escherichia coli outer membrane porin-C (anti-Omp-C), antibodies to clostridial flagellin (anti-CBir-1), and perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA) were compared in patients by age in three diagnosis groups: patients diagnosed at ages of <40, ≥40-59, and ≥60 years...
2015: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/26078663/association-of-familial-mediterranean-fever-in-turkish-children-with-inflammatory-bowel-disease
#11
Ömer Faruk Beşer, Fügen Çullu Çokuğraş, Tufan Kutlu, Ethem Erginöz, Didem Gülcü, Özgür Kasapçopur, Tülay Erkan
AIM: Familial Mediterranean fever (FMF) and inflammatory bowel disease (IBD) carry similar clinical and biological properties. Both are characterized with chronic inflammation attacks and neutrophil migration and impaired apoptosis mechanism are present in the areas of damage in both conditions. In our study, we aimed to determine the frequency of association of FMF in patients with IBD, to compare the demographic, clinical, laboratory and treatment response properties in these patients with the ones in other IBD patients and to determine association of FMF especially in treatment-resistant patients...
September 2014: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/26026602/attenuation-of-colitis-by-serum-derived-bovine-immunoglobulin-protein-isolate-in-a-defined-microbiota-mouse-model
#12
Abigail L Henderson, Meghan Wymore Brand, Ross J Darling, Kenneth J Maas, Christopher J Detzel, Jesse Hostetter, Michael J Wannemuehler, Eric M Weaver
BACKGROUND: The pathogenesis of inflammatory bowel disease (IBD) is complex and multifaceted including genetic predisposition, environmental components, microbial dysbiosis, and inappropriate immune activation to microbial components. Pathogenic bacterial provocateurs like adherent and invasive E. coli have been reported to increase susceptibility to Crohn's disease. Serum-derived bovine immunoglobulin/protein isolate (SBI) is comprised primarily of immunoglobulins (Igs) that bind to conserved microbial components and neutralize exotoxins...
November 2015: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/26004193/vitamin-a-supplementation-leads-to-increases-in-regulatory-cd4-foxp3-lap-t-cells-in-mice
#13
Samara R Medeiros, Natalia Pinheiro-Rosa, Luisa Lemos, Flavia G Loli, Alline G Pereira, Andrezza F Santiago, Ester C Pinter, Andrea C Alves, Jamil S Oliveira, Denise C Cara, Tatiani U Maioli, Ana Maria C Faria
Dietary compounds, including micronutrients such as vitamin A and its metabolite retinoic acid, directly influence the development and function of the immune system. In this study, we show that either dietary deficiency of or supplementation with vitamin A had immunologic effects in mice that were fed these diets during their development (for 8 wk during the postweaning period). Deficient mice presented higher levels of interferon-γ, interleukin (IL)-6, transforming growth factor-β, IL-17, and IL-10 in the gut-associated lymphoid tissues and draining lymph nodes, indicating a proinflammatory shift in the gut mucosa...
October 2015: Nutrition
https://www.readbyqxmd.com/read/25993689/use-of-intravenous-immunoglobulin-for-patients-with-inflammatory-bowel-disease-with-contraindications-or-who-are-unresponsive-to-conventional-treatments
#14
Scott A Merkley, Dawn B Beaulieu, Sara Horst, Caroline Duley, Kim Annis, Anne Nohl, David A Schwartz
BACKGROUND: Managing patients with IBD who are refractory or have contraindications to standard therapies is challenging. Many will lose response, become intolerant to treatment, or develop infections with contraindication for immunosuppression. Therefore, alternative therapies, such as the use of intravenous immunoglobulin (IVIg), could be used to manage patients in these difficult cases. METHODS: Data were extracted retrospectively from the electronic medical records at Vanderbilt University on patients with IBD who received IVIg (February 2011-June 2013)...
August 2015: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/25882614/dietary-intervention-with-serum-derived-bovine-immunoglobulins-protects-barrier-function-in-a-mouse-model-of-colitis
#15
Anna Pérez-Bosque, Lluïsa Miró, Mònica Maijó, Javier Polo, Joy Campbell, Louis Russell, Joe Crenshaw, Eric Weaver, Miquel Moretó
Dietary supplementation with immunoglobulins from animal plasma has anti-inflammatory effects on intestinal and lung models of acute inflammation. Here, we aimed to establish whether dietary intervention with serum-derived bovine immunoglobulin (SBI) can prevent alterations in intestinal barrier function in a mouse model with a genetic predisposition to inflammatory bowel disease (IBD). Wild-type (WT) mice and mice lacking the mdr1a gene (KO) were fed diets supplemented with either SBI (2% wt/wt) or milk proteins (control diet), from day 21 (weaning) until day 56...
June 15, 2015: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/25878173/antiphospholipid-antibodies-and-procoagulant-profile-in-tunisians-with-inflammatory-bowel-diseases
#16
Imen Kraiem, Samira Hadhri, Mohamed Ben Rejeb, Lamia Ifa, Ali Jmaa, Salem Ajmi, Hadef Skouri
The hypercoagulable state accompanying inflammatory bowel diseases (IBDs) is still poorly understood. The aim of this study was to assess antiphospholipid antibodies (APAs) and a large panel of inherited and acquired thrombotic markers simultaneously in a sample of Tunisian patients with IBD. In total, 89 consecutive patients with IBD (mean age 38 ± 15 years; 48 with Crohn disease and 41 with ulcerative colitis) and 129 controls were prospectively evaluated for immunoglobulin (Ig) G, IgM, and IgA antibodies against cardiolipin (aCL), β2glycoprotein I (aβ2GPI), and prothrombin (aPT); IgG and IgM antibodies against phosphatidic acid (aPA), phosphatidylinositol (aPI), and annexin V (aAnnV); lupus anticoagulant (LA); coagulation factors; natural inhibitors; and thrombotic genetic polymorphisms...
April 15, 2015: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/25872173/laparoscopic-and-percutaneous-core-needle-biopsy-plays-a-central-role-for-the-diagnosis-of-autoimmune-pancreatitis-in-a-single-center-study-from-denmark
#17
COMPARATIVE STUDY
Sönke Detlefsen, Michael Bau Mortensen, Torsten Kjærulff Pless, Anne-Sofie Cribe, Ove B Schaffalitzky de Muckadell
OBJECTIVES: The aims of this study were to describe the diagnosis of autoimmune pancreatitis (AIP) in Denmark and to test the usefulness of the International Consensus Diagnostic Criteria (ICDC) on a geographically well-defined cohort. METHODS: All patients diagnosed with AIP at Odense University Hospital from 2007 to 2013 were included (n = 30; mean follow-up, 26.2 months). Data from laparoscopic or percutaneous ultrasound-guided core needle biopsy (CNB), resection specimens, endoscopic ultrasound (EUS), EUS-guided CNB, computed tomography, serum immunoglobulin G4 (IgG4), and pancreatography were retrospectively analyzed according to ICDC...
August 2015: Pancreas
https://www.readbyqxmd.com/read/25866735/disseminated-cytomegalovirus-infection-and-protein-losing-enteropathy-as-presenting-feature-of-pediatric-patient-with-crohn-s-disease
#18
Murat Cakir, Safak Ersoz, Ulas Emre Akbulut
We report a pediatric patient admitted with abdominal pain, diffuse lower extremity edema and watery diarrhea for two months. Laboratory findings including complete blood count, serum albumin, lipid and immunoglobulin levels were compatible with protein losing enteropathy. Colonoscopic examination revealed diffuse ulcers with smooth raised edge (like "punched out holes") in the colon and terminal ileum. Histopathological examination showed active colitis, ulcerations and inclusion bodies. Immunostaining for cytomegalovirus was positive...
March 2015: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/25864802/successful-modulation-of-murine-lupus-nephritis-with-tuftsin-phosphorylcholine
#19
Tomer Bashi, Miri Blank, Dana Ben-Ami Shor, Mati Fridkin, Mathilde Versini, Omer Gendelman, Alexander Volkov, Iris Barshak, Yehuda Shoenfeld
In areas where helminths infections are common, autoimmune diseases are rare. Treatment with helminths and ova from helminths, improved clinical findings of inflammatory bowel disease, multiple-sclerosis and rheumatoid-arthritis. The immunomodulatory functions of some helminths were attributed to the phosphorylcholine (PC) moiety. We aimed to decipher the tolerogenic potential of Tuftsin-PC (TPC) compound in mice genetically prone to develop lupus. Lupus prone NZBXW/F1 mice received subcutaneously TPC (5 μg/1 ml), 3 times a week starting at 14 weeks age...
May 2015: Journal of Autoimmunity
https://www.readbyqxmd.com/read/25830826/bovine-immunoglobulin-protein-isolate-binds-pro-inflammatory-bacterial-compounds-and-prevents-immune-activation-in-an-intestinal-co-culture-model
#20
Christopher J Detzel, Alan Horgan, Abigail L Henderson, Bryon W Petschow, Christopher D Warner, Kenneth J Maas, Eric M Weaver
Intestinal barrier dysfunction is associated with chronic gastrointestinal tract inflammation and diseases such as IBD and IBS. Serum-derived bovine immunoglobulin/protein isolate (SBI) is a specially formulated protein preparation (>90%) for oral administration. The composition of SBI is greater than 60% immunoglobulin including contributions from IgG, IgA, and IgM. Immunoglobulin within the lumen of the gut has been recognized to have anti-inflammatory properties and is involved in maintaining gut homeostasis...
2015: PloS One
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