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https://www.readbyqxmd.com/read/28092864/augmentation-of-humoral-and-cellular-immunity-in-response-to-tetanus-and-diphtheria-toxoids-by-supercritical-carbon-dioxide-extracts-of-hippophae-rhamnoides-l-leaves
#1
Bindhya Jayashankar, Divya Singh, Himanshi Tanwar, K P Mishra, Swetha Murthy, Sudipta Chanda, Jigni Mishra, R Tulswani, K Misra, S B Singh, Lilly Ganju
Hippophae rhamnoides L. commonly known as Seabuckthorn (SBT), a wild shrub of family Elaegnacea, has extensively used for treating various ailments like skin diseases, jaundice, asthma, lung troubles. SBT leaves have been reported to possess several pharmacological properties including immunomodulatory, antioxidant, anti-inflammatory, antimicrobial and tissue regeneration etc. The present study was undertaken to evaluate the adjuvant property of supercritical carbon dioxide extracts (SCEs 300ET and 350ET) of SBT leaves in balb/c mice immunized with Tetanus and Diphtheria toxoids...
January 13, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28075423/effects-of-device-guided-slow-breathing-training-on-exercise-capacity-cardiac-function-and-respiratory-patterns-during-sleep-in-male-and-female-patients-with-chronic-heart-failure
#2
Kalina Kawecka-Jaszcz, Grzegorz Bilo, Tomasz Drożdż, Dorota Dębicka-Dąbrowska, Grzegorz Kiełbasa, Gabriella Malfatto, Katarzyna Styczkiewicz, Carolina Lombardi, Agnieszka Bednarek, Sabrina Salerno, Danuta Czarnecka, Gianfranco Parati
INTRODUCTION    Slow breathing training (SBT) has been proposed as new non-pharmacological treatment in chronic heart failure (CHF) patients.  OBJECTIVES    The aim of this study was to assess the effects of SBT on exercise capacity, haemodynamic parameters and sleep respiratory patterns in a relatively large sample of CHF patients. PATIENTS ABD METHODS    A cross-over open study was conducted. The patients completed, in random order, 10-12 week periods of SBT with the RESPeRATE device (InterCure Ltd...
January 10, 2017: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/28060461/responsiveness-of-the-bridge-maneuvers-in-subjects-with-symptomatic-lumbar-spondylolisthesis-a-prospective-cohort-study
#3
Carla Vanti, Silvano Ferrari, Pedro Berjano, Jorge Hugo Villafañe, Marco Monticone
BACKGROUND AND PURPOSE: To date no study was made on the responsiveness of Bridge tests (BTs) in subjects with low back pain and spondylolisthesis (SPL) submitted to a physical therapy program. The objective of this study is to examine the responsiveness of the BTs in subjects with symptomatic lumbar SPL. METHODS: One hundred twenty patients with symptomatic SPL received physical therapy treatments for a number of sessions depending on the individual patient's needs...
January 6, 2017: Physiotherapy Research International: the Journal for Researchers and Clinicians in Physical Therapy
https://www.readbyqxmd.com/read/28049209/diagnostic-value-of-serum-baseline-tryptase-levels-in-childhood-asthma-and-its-correlation-with-disease-severity
#4
Siju Gao, Jingang Fan, Zhaoan Wang
BACKGROUND: The aim of this study was to explore whether serum baseline tryptase (sBT) levels might be a useful marker not only for the accurate diagnosis of childhood asthma, but also for the prediction of disease severity. METHODS: A total of 114 asthmatic children were enrolled in this study, 36 of whom had mild intermittent asthma, 38 had mild persistent asthma, and 40 had moderate to severe persistent asthma. Additionally, 34 age-matched healthy children were enrolled as controls...
2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28025670/ovarian-borderline-tumors-in-the-2014-who-classification-evolving-concepts-and-diagnostic-criteria
#5
REVIEW
Steffen Hauptmann, Katrin Friedrich, Raymond Redline, Stefanie Avril
Borderline ovarian tumors (BOT) are uncommon but not rare epithelial ovarian neoplasms, intermediate between benign and malignant categories. Since BOT were first identified >40 years ago, they have inspired controversies disproportionate to their incidence. This review discusses diagnostic criteria for the histologic subtypes of BOT, highlighting areas of diagnostic challenges, ongoing controversies, and changes in terminology implemented by the recent 2014 WHO Classification of Tumours of the Female Genital Organs...
December 27, 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28011997/do-salivary-bypass-tubes-lower-the-incidence-of-pharyngocutaneous-fistula-following-total-laryngectomy-a-retrospective-analysis-of-predictive-factors-using-multivariate-analysis
#6
Robert W A Hone, Eqramur Rahman, Gentle Wong, Yvette Annan, Victoria Alexander, Ali Al-Lami, Kiran Varadharajan, Michael Parker, Ricard Simo, Lisa Pitkin, Alasdair Mace, Enyinnaya Ofo, Alistair Balfour, Iain J Nixon
Salivary bypass tubes (SBT) are increasingly used to prevent pharyngocutaneous fistula (PCF) following laryngectomy and pharyngolaryngectomy. There is minimal evidence as to their efficacy and literature is limited. The aim of the study was to determine if SBT prevent PCF. The study was a multicentre retrospective case control series (level of evidence 3b). Patients who underwent laryngectomy or pharyngolaryngectomy for cancer or following cancer treatment between 2011 and 2014 were included in the study...
December 23, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28003104/role-of-simulation-in-endovascular-aneurysm-repair-evar-training-a-preliminary-study
#7
A Saratzis, T Calderbank, D Sidloff, M J Bown, R S Davies
BACKGROUND: Endovascular aneurysm repair (EVAR) requires a high-level of technical-competency to avoid device-related complications. Virtual reality simulation-based training (SBT) may offer an alternative method of psychomotor skill acquisition; however, its role in EVAR training is undefined. This study aimed to: a) benchmark competency levels using EVAR SBT, and b) investigate the impact of supervised SBT on trainee performance. METHODS: EVAR procedure-related metrics were benchmarked by six experienced consultants using a Simbionix Angiomentor EVAR simulator...
December 18, 2016: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/27986510/simulation-based-training-for-cardiology-procedures-are-we-any-further-forward-in-evidencing-real-world-benefits
#8
REVIEW
Christopher M Harrison, Jivendra N Gosai
Simulation-based training as an educational tool for healthcare professionals continues to grow in sophistication, scope, and usage. There have been a number of studies demonstrating the utility of the technique, and it is gaining traction as part of the training curricula for the next generation of cardiologists. In this review, we focus on the recent literature for the efficacy of simulation for practical procedures specific to cardiology, focusing on transesophageal echocardiography, cardiac catheterization, coronary angioplasty, and electrophysiology...
September 1, 2016: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27984618/-identification-of-a-novel-hla-allele-a-29-49-using-sequence-based-typing
#9
Yan Chen, Yujie Li, Xiaojie Xu, Peicong Zhai, Yi Zhang, Chuanfu Zhu
OBJECTIVE: To report on a novel HLA-A allele, A*29:49, identified in a Chinese Han population by sequence based typing (SBT). METHODS: A donor from China Marrow Donor Programme (CMDP) was typed with a bi-allelic PCR-SBT kit, and no full matched result was obtained for the HLA-A locus. The novel HLA allele was verified with an allele-specific amplification SBT kit. RESULTS: A novel HLA-A allele was identified, which has differed by one nucleotide from the closest matched allele, HLA-A*29:01:01:01, at position 368(A→T), codon 99 (TAT→TTT), resulting in an amino acid substitution (Y→F)...
December 10, 2016: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/27984603/-a-strategy-to-clarify-ambiguities-during-genotyping-of-functional-kir-framework-genes-by-sequencing-based-typing-among-ethnic-hans-from-southern-china
#10
Guobin Zhang, Zhihui Deng
OBJECTIVE: To categorize ambiguous allelic combinations encountered in genotyping of functional KIR genes by sequencing-based typing of the entire coding sequence and develop an efficient approach to identify such ambiguities. METHODS: Fourteen KIR functional framework genes from 306 ethnic Chinese individuals were genotyped for the entire encoding sequence. The number of ambiguities was directly counted. Based on the differences within each ambiguous allelic combination, group-specific PCR primers and sequencing primers for amplifying the target allelic sequence were designed...
December 10, 2016: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/27940581/precursor-processing-for-plant-peptide-hormone-maturation-by-subtilisin-like-serine-proteinases
#11
Katharina Schardon, Mathias Hohl, Lucile Graff, Jens Pfannstiel, Waltraud Schulze, Annick Stintzi, Andreas Schaller
Peptide hormones that regulate plant growth and development are derived from larger precursor proteins by proteolytic processing. Our study addressed the role of subtilisin-like proteinases (SBTs) in this process. Using tissue-specific expression of proteinase inhibitors as a tool to overcome functional redundancy, we found that SBT activity was required for the maturation of IDA (INFLORESCENCE DEFICIENT IN ABSCISSION), a peptide signal for the abscission of floral organs in Arabidopsis We identified three SBTs that process the IDA precursor in vitro, and this processing was shown to be required for the formation of mIDA (the mature and bioactive form of IDA) as the endogenous signaling peptide in vivo...
December 23, 2016: Science
https://www.readbyqxmd.com/read/27936874/effects-of-physician-targeted-pay-for-performance-on-use-of-spontaneous-breathing-trials-in-mechanically-ventilated-patients
#12
Ian J Barbash, Francis Pike, Scott R Gunn, Christopher W Seymour, Jeremy M Kahn
Rationale Pay-for-performance is an increasingly common quality improvement strategy despite the absence of robust supporting evidence. Objectives To determine the impact of a financial incentive program rewarding physicians for the completion of daily spontaneous breathing trials (SBTs) in three academic hospitals. Methods We compared data from mechanically ventilated patients from six months before to two years after introduction of a financial incentive program that provided annual payments to critical care physicians contingent on unit-level SBT completion rates...
December 12, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27909438/donor-specific-regulatory-t-cells-acquired-from-tolerant-mice-bearing-cardiac-allograft-promote-mixed-chimerism-and-prolong-intestinal-allograft-survival
#13
Xiao-Fei Shen, Jin-Peng Jiang, Jian-Jun Yang, Wei-Zhong Wang, Wen-Xian Guan, Jun-Feng Du
The induction of donor-specific transplant tolerance has always been a central problem for small bowel transplantation (SBT), which is thought to be the best therapy for end-stage bowel failure. With the development of new tolerance-inducing strategies, mixed chimerism induced by co-stimulation blockade has become most potent for tolerance of allografts, such as skin, kidney, and heart. However, a lack of clinically available co-stimulation blockers has hindered efficient application in humans. Furthermore, unlike those for other types of solid organ transplantation, strategies to induce robust mixed chimerism for intestinal allografts have not been fully developed...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27857870/persistent-trigeminal-artery-in-endonasal-resection-of-skull-base-tumors-a-systematic-review
#14
Jasper Shen, James Tourje, Elena E Chang, Adam N Mamelak, Arthur W Wu
Background Primitive persistent trigeminal artery (PTA) is an uncommon embryologic vascular communication between the carotid and basilar arteries, which can be intimately involved by skull base tumors (SBT). Owing to its rarity, skull base surgeons should familiarize themselves with the anatomical variations of PTA to avoid catastrophic complications. Objective To appraise and summarize the available evidence of PTA involved by SBTs while advocating a standardized algorithm for the surgical planning of these patients...
December 2016: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/27850689/1051-the-effect-of-rass-scores-and-time-from-sbt-on-extubation-success-in-the-icu-an-update
#15
Stephen Yau, Meagan Dubosky, Carl Kaplan, David Vines
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27836002/cardiac-dysfunction-induced-by-weaning-from-mechanical-ventilation-incidence-risk-factors-and-effects-of-fluid-removal
#16
Jinglun Liu, Feng Shen, Jean-Louis Teboul, Nadia Anguel, Alexandra Beurton, Nadia Bezaz, Christian Richard, Xavier Monnet
BACKGROUND: Weaning-induced pulmonary oedema (WiPO) is a well-recognised cause of failure of weaning from mechanical ventilation, but its incidence and risk factors have not been reliably described. We wanted to determine the incidence and risk factors in a population of critically ill patients. In addition, we wanted to describe the effects of diuretics when they are administered in this context. METHODS: We monitored 283 consecutive spontaneous breathing trials (SBT; T-piece trial) performed in 81 patients...
November 12, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27826965/validation-of-a-rapid-robust-inexpensive-screening-method-for-detecting-the-hla-b-58-01-allele-in-the-prevention-of-allopurinol-induced-severe-cutaneous-adverse-reactions
#17
Dinh Van Nguyen, Christopher Vida, Hieu Chi Chu, Richard Fulton, Jamma Li, Suran L Fernando
The HLA B*58:01 allele has been worldwide reported as a pharmacogenetic susceptibility to allopurinol-induced severe cutaneous adverse reactions (SCARs). To prevent these life-threatening conditions, the American College of Rheumatology hingly recommended that the HLA-B*58:01 be screened prior to the initiation of allopurinol therapy. Therefore, we developed a rapid, robust, inexpensive screening method using SYBR® Green real time PCR to detect the HLA-B*58:01 allele. A total of 119 samples were tested. The assay has a sensitivity of 100% (95% CI: 69...
January 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/27826111/effect-of-ranching-time-on-melanomacrophage-centres-in-anterior-kidney-and-spleen-of-southern-bluefin-tuna-thunnus-maccoyii
#18
Daryl Evans, Barbara Nowak
Melanomacrophage centres (MMCs) are common in the haemopoietic tissue of fish and are an important component of the humoral immune response. Increasingly they are being studied as a biomarker of environmental stress in both wild and aquaculture fish stocks. Computer image analysis of histological sections of the head kidney and spleen of ranched Southern bluefin tuna (SBT) was used to investigate changes in MMCs over various stages of the ranching cycle. Histochemical pigment differentiation indicated haemosiderin, lipofuscin and melanin were present in MMCs of both the kidney and spleen, with kidney MMCs being highly positive for lipofuscin and melanin and spleen having high levels of haemosiderin and a lower level of melanin than kidney...
December 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27818331/liberation-from-mechanical-ventilation-in-critically-ill-adults-an%C3%A2-official-american-college-of-chest-physicians-american-thoracic-society-clinical-practice-guideline-inspiratory-pressure-augmentation-during-spontaneous-breathing-trials-%C3%A2-protocols-minimizing
#19
Daniel R Ouellette, Sheena Patel, Timothy D Girard, Peter E Morris, Gregory A Schmidt, Jonathon D Truwit, Waleed Alhazzani, Suzanne M Burns, Scott K Epstein, Andres Esteban, Eddy Fan, Miguel Ferrer, Gilles L Fraser, Michelle Ng Gong, Catherine L Hough, Sangeeta Mehta, Rahul Nanchal, Amy J Pawlik, William D Schweickert, Curtis N Sessler, Thomas Strøm, John P Kress
BACKGROUND: An update of evidence-based guidelines concerning liberation from mechanical ventilation is needed as new evidence has become available. The American College of Chest Physicians (CHEST) and the American Thoracic Society (ATS) have collaborated to provide recommendations to clinicians concerning liberation from the ventilator. METHODS: Comprehensive evidence syntheses, including meta-analyses, were performed to summarize all available evidence relevant to the guideline panel's questions...
January 2017: Chest
https://www.readbyqxmd.com/read/27804255/a-randomized-trial-of-an-acceptance-based-behavioral-intervention-for-weight-loss-in-people-with-high-internal-disinhibition
#20
Jason Lillis, Heather M Niemeier, J Graham Thomas, Jessica Unick, Kathryn M Ross, Tricia M Leahey, Kathleen E Kendra, Leah Dorfman, Rena R Wing
OBJECTIVE: To determine whether an acceptance-based behavioral intervention (ABBI) produces better weight losses than standard behavioral treatment (SBT) among individuals reporting high internal disinhibition. METHODS: Participants were 162 adults with overweight or obesity (mean BMI 37.6 kg/m(2) ) randomly assigned to ABBI or SBT. Both interventions provided the same calorie intake target, exercise goal, and self-monitoring skills training. SBT incorporated current best practice interventions for addressing problematic thoughts and emotions...
December 2016: Obesity
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