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https://www.readbyqxmd.com/read/27909438/donor-specific-regulatory-t-cells-acquired-from-tolerant-mice-bearing-cardiac-allograft-promote-mixed-chimerism-and-prolong-intestinal-allograft-survival
#1
Xiao-Fei Shen, Jin-Peng Jiang, Jian-Jun Yang, Wei-Zhong Wang, Wen-Xian Guan, Jun-Feng Du
The induction of donor-specific transplant tolerance has always been a central problem for small bowel transplantation (SBT), which is thought to be the best therapy for end-stage bowel failure. With the development of new tolerance-inducing strategies, mixed chimerism induced by co-stimulation blockade has become most potent for tolerance of allografts, such as skin, kidney, and heart. However, a lack of clinically available co-stimulation blockers has hindered efficient application in humans. Furthermore, unlike those for other types of solid organ transplantation, strategies to induce robust mixed chimerism for intestinal allografts have not been fully developed...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27857870/persistent-trigeminal-artery-in-endonasal-resection-of-skull-base-tumors-a-systematic-review
#2
Jasper Shen, James Tourje, Elena E Chang, Adam N Mamelak, Arthur W Wu
Background Primitive persistent trigeminal artery (PTA) is an uncommon embryologic vascular communication between the carotid and basilar arteries, which can be intimately involved by skull base tumors (SBT). Owing to its rarity, skull base surgeons should familiarize themselves with the anatomical variations of PTA to avoid catastrophic complications. Objective To appraise and summarize the available evidence of PTA involved by SBTs while advocating a standardized algorithm for the surgical planning of these patients...
December 2016: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/27850689/1051-the-effect-of-rass-scores-and-time-from-sbt-on-extubation-success-in-the-icu-an-update
#3
Stephen Yau, Meagan Dubosky, Carl Kaplan, David Vines
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27836002/cardiac-dysfunction-induced-by-weaning-from-mechanical-ventilation-incidence-risk-factors-and-effects-of-fluid-removal
#4
Jinglun Liu, Feng Shen, Jean-Louis Teboul, Nadia Anguel, Alexandra Beurton, Nadia Bezaz, Christian Richard, Xavier Monnet
BACKGROUND: Weaning-induced pulmonary oedema (WiPO) is a well-recognised cause of failure of weaning from mechanical ventilation, but its incidence and risk factors have not been reliably described. We wanted to determine the incidence and risk factors in a population of critically ill patients. In addition, we wanted to describe the effects of diuretics when they are administered in this context. METHODS: We monitored 283 consecutive spontaneous breathing trials (SBT; T-piece trial) performed in 81 patients...
November 12, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27826965/validation-of-a-rapid-robust-inexpensive-screening-method-for-detecting-the-hla-b-58-01-allele-in-the-prevention-of-allopurinol-induced-severe-cutaneous-adverse-reactions
#5
Dinh Van Nguyen, Christopher Vida, Hieu Chi Chu, Richard Fulton, Jamma Li, Suran L Fernando
The HLA B*58:01 allele has been worldwide reported as a pharmacogenetic susceptibility to allopurinol-induced severe cutaneous adverse reactions (SCARs). To prevent these life-threatening conditions, the American College of Rheumatology hingly recommended that the HLA-B*58:01 be screened prior to the initiation of allopurinol therapy. Therefore, we developed a rapid, robust, inexpensive screening method using SYBR® Green real time PCR to detect the HLA-B*58:01 allele. A total of 119 samples were tested. The assay has a sensitivity of 100% (95% CI: 69...
January 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/27826111/effect-of-ranching-time-on-melanomacrophage-centres-in-anterior-kidney-and-spleen-of-southern-bluefin-tuna-thunnus-maccoyii
#6
Daryl Evans, Barbara Nowak
Melanomacrophage centres (MMCs) are common in the haemopoietic tissue of fish and are an important component of the humoral immune response. Increasingly they are being studied as a biomarker of environmental stress in both wild and aquaculture fish stocks. Computer image analysis of histological sections of the head kidney and spleen of ranched Southern bluefin tuna (SBT) was used to investigate changes in MMCs over various stages of the ranching cycle. Histochemical pigment differentiation indicated haemosiderin, lipofuscin and melanin were present in MMCs of both the kidney and spleen, with kidney MMCs being highly positive for lipofuscin and melanin and spleen having high levels of haemosiderin and a lower level of melanin than kidney...
December 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27818331/liberation-from-mechanical-ventilation-an-official-american-college-of-chest-physicians-american-thoracic-society-clinical-practice-guideline-inspiratory-pressure-augmentation-during-spontaneous-breathing-trials-protocols-minimizing-sedation-and-non-invasive
#7
Daniel R Ouellette, Sheena Patel, Timothy D Girard, Peter E Morris, Gregory A Schmidt, Jonathon D Truwit, Waleed Al-Hazzani, Suzanne M Burns, Scott K Epstein, Andres Esteban, Eddy Fan, Miguel Ferrer, Gilles L Fraser, Michelle Gong, Catherine L Hough, Sangeeta Mehta, Rahul Nanchal, Amy J Pawlik, William Schweickert, Curtis N Sessler, Thomas Strøm, John P Kress
BACKGROUND: An update of evidence-based guidelines concerning liberation from mechanical ventilation is needed as new evidence has become available. The American College of Chest Physicians (CHEST) and the American Thoracic Society (ATS) have collaborated to provide recommendations to clinicians concerning ventilator liberation. METHODS: Comprehensive evidence syntheses, including meta-analyses, were performed to summarize all available evidence relevant to the guideline panel's questions...
November 3, 2016: Chest
https://www.readbyqxmd.com/read/27804255/a-randomized-trial-of-an-acceptance-based-behavioral-intervention-for-weight-loss-in-people-with-high-internal-disinhibition
#8
Jason Lillis, Heather M Niemeier, J Graham Thomas, Jessica Unick, Kathryn M Ross, Tricia M Leahey, Kathleen E Kendra, Leah Dorfman, Rena R Wing
OBJECTIVE: To determine whether an acceptance-based behavioral intervention (ABBI) produces better weight losses than standard behavioral treatment (SBT) among individuals reporting high internal disinhibition. METHODS: Participants were 162 adults with overweight or obesity (mean BMI 37.6 kg/m(2) ) randomly assigned to ABBI or SBT. Both interventions provided the same calorie intake target, exercise goal, and self-monitoring skills training. SBT incorporated current best practice interventions for addressing problematic thoughts and emotions...
December 2016: Obesity
https://www.readbyqxmd.com/read/27784392/-identification-of-a-novel-hla-b-13-92-allele-and-analysis-of-its-3d-model-structure
#9
Yong-Feng Pei, Hui-Ni Huang, Heng-Cong Li, Guo-Guang Wu
OBJECTIVE: To identify a novel human leukocyte antigen (HLA) allele HLA-B*13:92 and analyze 3D model of HLA molecule. METHODS: Polymerase chain reaction sequencing-based (PCR-SBT) was used in routine HLA typing, the B locus typing results of one sample was one base mismatch with B*13:01:01, B*58:01:01 at locus 189, The Group Specific Sequencing Products (GSSP) which target at B*13 and B*58 were used to confirm difference between the new allele and highest homologous allele, then the new allele was modeled by Swiss-model to its 3D structure...
October 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/27768396/effort-to-breathe-with-various-spontaneous-breathing-trial-techniques-a-physiological-meta-analysis
#10
Michael C Sklar, Karen Burns, Nuttapol Rittayamai, Ashley Lanys, Michela Rauseo, Lu Chen, Martin Dres, Guang-Qiang Chen, Ewan C Goligher, Neill Kj Adhikari, Laurent Brochard, Jan O Friedrich
Introduction Spontaneous breathing trials (SBTs) are designed to simulate conditions following extubation and it is essential to understand the physiological impact of different methods. We conducted a systematic review and pooled measures reflecting patient respiratory effort among studies comparing SBT methods in a meta-analysis. Methods We searched Medline, EMBASE, and Web of Science from inception to January 2016 to identify randomized and non-randomized clinical trials reporting physiological measurements of respiratory effort (pressure-time product, PTP) or work of breathing during at least 2 SBT techniques...
October 21, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27766023/lower-body-mass-index-is-a-risk-factor-for-in-hospital-mortality-of-elderly-japanese-patients-treated-with-ampicillin-sulbactam
#11
Makoto Miura, Akiko Kuwahara, Akinori Tomozawa, Naoki Omae, Motohiro Yamamori, Kaori Kadoyama, Toshiyuki Sakaeda
Objectives: A retrospective examination was conducted to identify risk factors for in-hospital mortality of elderly patients (65 years or older) treated with the beta-lactam/beta-lactamase inhibitor combination antibiotic, ampicillin/sulbactam (ABPC/SBT). Methods: Clinical data from 96 patients who were hospitalized with infectious diseases and treated with ABPC/SBT (9 g/day or 12 g/day) were analyzed. Risk factors examined included demographic and clinical laboratory parameters. Parameter values prior to treatment and changes after treatment were compared between survivors and non-survivors...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27755248/the-combination-of-sat-and-sbt-protocols-may-help-reduce-the-incidence-of-ventilator-associated-pneumonia-in-the-burn-intensive-care-unit
#12
Yann-Leei Larry Lee, Kaci D Sims, Charles C Butts, M Amin Frotan, Steven Kahn, Sidney B Brevard, Jon D Simmons
There are few published reports on the unique nature of burn patients using a paired spontaneous awakening and spontaneous breathing protocol. A combined protocol was implemented in our burn intensive care unit (ICU) on January 1, 2012. This study evaluates the impact of this protocol on patient outcomes in a burn ICU. We performed a retrospective review of our burn registry over 4 years, including all patients placed on mechanical ventilation. In the latter 2 years, patients meeting criteria underwent daily spontaneous awakening trial; if successful, spontaneous breathing trial was performed...
October 6, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27753600/impact-of-time-to-treatment-on-the-effects-of-bivalirudin-vs-glycoprotein-iib-iiia-inhibitors-and-heparin-in-patients-undergoing-primary-percutaneous-coronary-intervention-insights-from-the-horizons-ami-trial
#13
Mikkel M Schoos, Giuseppe De Luca, George D Dangas, Peter Clemmensen, Girma Minalu Ayele, Roxana Mehran, Gregg W Stone
AIMS: In the HORIZONS-AMI trial, bivalirudin compared to unfractionated heparin (UFH) plus a glycoprotein IIb/IIIa inhibitor (GPI) improved net clinical outcomes in patients undergoing primary percutaneous coronary intervention (PCI) at the cost of an increased rate of acute stent thrombosis. We sought to examine whether these effects are dependent on time to treatment. METHODS AND RESULTS: The interaction between anticoagulation regimen and symptom onset to first balloon inflation time (SBT) on the 30-day and three-year rates of major adverse cardiac events (MACE) was examined in 3,199 randomised patients according to SBT ≤3 hours versus >3 hours...
October 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27747447/cardioprotective-effects-of-mitochondria-targeted-peptide-sbt-20-in-two-different-models-of-rat-ischemia-reperfusion
#14
Wangde Dai, Elissa Cheung, Rick J Alleman, Justin B Perry, Mitchell E Allen, David A Brown, Robert A Kloner
PURPOSE: Dysfunctional mitochondria are considered to be the major source of intracellular reactive oxygen species and play a central role in the pathophysiology of myocardial ischemia/reperfusion. This study sought to determine effects of mitochondria-targeted cytoprotective peptide SBT-20 on myocardial infarct size in two different models of ischemia/reperfusion. METHODS: For in vivo studies, anesthetized Sprague Dawley rats were subjected to 30 min of coronary artery occlusion followed by 3 h of reperfusion...
October 17, 2016: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/27714943/is-hla-e-a-possible-genetic-marker-relevant-for-natural-conception
#15
Georgia Fernanda Gelmini, Cynthia Hernandes Costa, Fabiola da Silva Nardi, Pryscilla Fanini Wowk, Sibelle Botogosque Mattar, Alessandro Schuffner, Maria da Graça Bicalho, Valéria Maria Munhoz Sperandio Roxo
BACKGROUND: HLA-E products, class Ib human leukocyte antigens, act in the immunology of human reproduction as modulators of the maternal immune system during pregnancy. AIMS: To evaluate HLA-E role in the establishment of a viable pregnancy. MATERIALS & METHODS: HLA-E was genotyped by sequence-based typing (SBT) and analyzed for specific polymorphisms, comparing couples who underwent assisted reproduction treatment (ART) and fertile control couples...
December 2016: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/27706210/molecular-typing-of-legionella-pneumophila-isolates-in-the-province-of-quebec-from-2005-to-2015
#16
Simon Lévesque, Cindy Lalancette, Kathryn Bernard, Ana Luisa Pacheco, Réjean Dion, Jean Longtin, Cécile Tremblay
Legionella is found in natural and man-made aquatic environments, such as cooling towers and hot water plumbing infrastructures. Legionella pneumophila serogroup 1 (Lp1) is the most common etiological agent causing waterborne disease in the United States and Canada. This study reports the molecular characterization of Lp strains during a 10 year period. We conducted sequence-based typing (SBT) analysis on a large set of Lp isolates (n = 284) to investigate the province of Quebec sequence types (STs) distribution in order to identify dominant clusters...
2016: PloS One
https://www.readbyqxmd.com/read/27685098/a-simple-approach-for-measuring-fret-in-fluorescent-biosensors-using-two-photon-microscopy
#17
Richard N Day, Wen Tao, Kenneth W Dunn
Genetically encoded fluorescent protein (FP)-based biosensor probes are useful tools for monitoring cellular events in living cells and tissues. Because these probes were developed for one-photon excitation approaches, their broad two-photon excitation (2PE) and poorly understood photobleaching characteristics have made their implementation in studies using two-photon laser-scanning microscopy (TPLSM) challenging. Here we describe a protocol that simplifies the use of Förster resonance energy transfer (FRET)-based biosensors in TPLSM...
November 2016: Nature Protocols
https://www.readbyqxmd.com/read/27684813/training-on-an-inexpensive-tablet-based-device-is-equally-effective-as-on-a-standard-laparoscopic-box-trainer-a-randomized-controlled-trial
#18
Eliana Montanari, Richard Schwameis, Marisa Louridas, Christian Göbl, Lorenz Kuessel, Stephan Polterauer, Heinrich Husslein
BACKGROUND: The aim of the study was to assess whether an inexpensive tablet-based box trainer (TBT) is at least equally effective compared with a standard box trainer (SBT) to learn basic laparoscopic skills (BLS). BLS training outside the operating room has been shown to be beneficial for surgical residency. However, simulation trainers are expensive and are not consistently available in all training centers. Therefore, TBT and other homemade box trainers were developed. METHODS: Medical students were randomized to either a TBT or an SBT and trained 4 fundamentals of laparoscopic surgery (FLS) tasks for 1 hour twice a week for 4 weeks...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27678137/-simulation-based-training-and-or-apprenticeship-for-medical-students-a%C3%A2-prospective-randomized-single-blind-study-of-clinical-skills
#19
T Ott, I Schmidtmann, T Limbach, P F Gottschling, H Buggenhagen, S Kurz, G Pestel
BACKGROUND: Simulation-based training (SBT) has developed into an established method of medical training. Studies focusing on the education of medical students have used simulation as an evaluation tool for defined skills. A small number of studies provide evidence that SBT improves medical students' skills in the clinical setting. Moreover, they were strictly limited to a few areas, such as the diagnosis of heart murmurs or the correct application of cricoid pressure. Other studies could not prove adequate transferability from the skills gained in SBT to the patient site...
September 27, 2016: Der Anaesthesist
https://www.readbyqxmd.com/read/27677861/can-diaphragmatic-ultrasonography-performed-during-the-t-tube-trial-predict-weaning-failure-the-role-of-diaphragmatic-rapid-shallow-breathing-index
#20
Savino Spadaro, Salvatore Grasso, Tommaso Mauri, Francesca Dalla Corte, Valentina Alvisi, Riccardo Ragazzi, Valentina Cricca, Giulia Biondi, Rossella Di Mussi, Elisabetta Marangoni, Carlo Alberto Volta
BACKGROUND: The rapid shallow breathing index (RSBI), which is the ratio between respiratory rate (RR) and tidal volume (VT), is one of the most widely used indices to predict weaning outcome. Whereas the diaphragm plays a fundamental role in generating VT, in the case of diaphragmatic dysfunction the inspiratory accessory muscles may contribute. If this occurs during a weaning trial, delayed weaning failure is likely since the accessory muscles are more fatigable than the diaphragm. Hence, we hypothesised that the traditional RSBI could be implemented by substituting VT with the ultrasonographic evaluation of diaphragmatic displacement (DD)...
September 28, 2016: Critical Care: the Official Journal of the Critical Care Forum
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