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https://www.readbyqxmd.com/read/28809383/increasing-symptoms-in-irritable-bowel-symptoms-with-ingestion-of-galacto-oligosaccharides-are-mitigated-by-%C3%AE-galactosidase-treatment
#1
C J Tuck, K M Taylor, P R Gibson, J S Barrett, J G Muir
OBJECTIVES: Galacto-oligosaccharides (GOS) are dietary FODMAPs (fermentable carbohydrates) associated with triggering gastrointestinal symptoms in patients with irritable bowel syndrome (IBS). This randomized, double-blind, placebo-controlled, cross-over trial aimed to assess whether oral α-galactosidase co-ingestion with foods high in GOS and low in other FODMAPs would reduce symptoms. METHODS: Patients meeting the Rome III criteria for IBS who were hydrogen-producers on breath testing were recruited...
August 15, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28808861/epidemiology-of-sleep-disordered-breathing-and-heart-failure-what-drives-what
#2
REVIEW
Sushma M Dharia, Lee K Brown
PURPOSE OF REVIEW: The bidirectional relationships that have been demonstrated between heart failure (HF) and central sleep apnea (CSA) demand further exploration with respect to the implications that each condition has for the other. This review discusses the body of literature that has accumulated on these relationships and how CSA and its potential treatment may affect outcomes in patients with CSA. RECENT FINDINGS: Obstructive sleep apnea (OSA) can exacerbate hypertension, type 2 diabetes, obesity, and atherosclerosis, which are known predicates of HF...
August 14, 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28807576/evaluation-of-three-tidal-volumes-10-12-and-15%C3%A2-ml%C3%A2-kg-1-in-dogs-for-controlled-mechanical-ventilation-assessed-by-volumetric-capnography-a-randomized-clinical-trial
#3
Seline Bumbacher, Johannes P Schramel, Martina Mosing
OBJECTIVE: To evaluate three routinely used tidal volumes (VT; 10, 12 and 15 mL kg(-1)) for controlled mechanical ventilation (CMV) in lung-healthy anaesthetized dogs by assessing alveolar ventilation (VTalv) and dead space (DS). STUDY DESIGN: Prospective, randomized clinical trial. ANIMALS: A total of 36 client-owned dogs. METHODS: Dogs were randomly allocated to a VT of 10 (G10), 12 (G12) or 15 (G15) mL kg(-1). After induction CMV was started...
May 8, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28807071/single-rescuer-ventilation-using-a-bag-valve-mask-with-removable-external-handle-a-randomized-crossover-trial
#4
Paul Reed, Baruch Zobrist, Monica Casmaer, Steven G Schauer, Nurani Kester, Michael D April
Introduction Ventilation with a bag valve mask (BVM) is a challenging but critical skill for airway management in the prehospital setting. Hypothesis Tidal volumes received during single rescuer ventilation with a modified BVM with supplemental external handle will be higher than those delivered using a standard BVM among health care volunteers in a manikin model. METHODS: This study was a randomized crossover trial of adult health care providers performing ventilation on a manikin. Investigators randomized participants to perform single rescuer ventilation, first using either a BVM modified by addition of a supplemental external handle or a standard unmodified BVM (Spur II BVM device; Ambu; Ballerup, Denmark)...
August 15, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28796053/berberine-containing-quadruple-therapy-for-initial-helicobacter-pylori-eradication-an-open-label-randomized-phase-iv-trial
#5
Di Zhang, Li Ke, Zhen Ni, Yu Chen, Lin-Hui Zhang, Shao-Hua Zhu, Chan-Juan Li, Lei Shang, Jie Liang, Yong-Quan Shi
BACKGROUND: Due to increasing antimicrobial resistance, a bismuth-based quadruple regimen has been recommended as an alternative first-line therapy for Helicobacter pylori (H pylori) eradication. However, different results are varied greatly and the availability of bismuth was limited in some countries. We assessed the efficacy and safety of 14-day berberine-containing quadruple therapy as an alternative regimen for H pylori eradication. METHODS: In a randomized, open-label, non-inferiority, phase IV trial between November 25, 2014, and October 15, 2015, 612 treatment-naive patients were randomly assigned to 14-day berberine-containing (n = 308) or 14-day bismuth-containing (n = 304) quadruple therapy...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28795404/palliative-drug-treatments-for-breathlessness-in-cystic-fibrosis
#6
REVIEW
Nishant Jaiswal, Meenu Singh, Amit Agarwal, Kiran K Thumburu
BACKGROUND: Cystic fibrosis is a life-limiting autosomal recessive genetic illness. A feeling of shortness of breath is common in cystic fibrosis, especially as the disease progresses. Reversing the underlying cause is the priority when treating breathlessness (dyspnoea), but when it is not feasible, palliation (easing) becomes the primary goal to improve an individual's quality of life. A range of drugs administered by various routes have been used, but no definite guidelines are available...
August 10, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28790149/evaluation-of-endotracheal-tube-scraping-on-airway-resistance
#7
J Brady Scott, Meagan N Dubosky, David L Vines, Adewunmi S Sulaiman, Kyle R Jendral, Gagan Singh, Ankeet Patel, Carl A Kaplan, David P Gurka, Robert A Balk
BACKGROUND: Spontaneous breathing trials (SBTs) are used to assess the readiness for discontinuation of mechanical ventilation. When airway resistance (Raw) is elevated, the imposed work of breathing can lead to prolongation of mechanical ventilation. Biofilm and mucus build-up within the endotracheal tube (ETT) can increase Raw. Scraping the ETT can remove the biofilm build-up and decrease mechanical Raw. The primary aim of this study was to evaluate the impact of ETT scraping on Raw...
August 8, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28780968/efficacy-and-safety-of-rifaximin-associated-with-standard-triple-therapy-omeprazole-clarithromycin-and-amoxicillin-for-h-pylori-eradication-a-phase-iv-pilot-clinical-trial
#8
Mercedes Ramas, Maria G Donday, Adrian G McNicholl, Javier P Gisbert
BACKGROUND: A progressive decrease in Helicobacter pylori eradication rates has been described over the years, driving the need for new antibiotic treatments. AIM: To evaluate the efficacy and safety of the addition of rifaximin (Spiraxin(®)) to standard triple therapy (omeprazole, amoxicillin and clarithromycin) for the eradication of H. pylori. METHODS: Independent prospective clinical trial (EUDRACT no.: 2013-001080-23). Forty consecutive adult patients were included with H...
August 3, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/28780900/results-from-a-clinical-trial-evaluating-the-efficacy-of-real-time-body-surface-visual-feedback-in-reducing-patient-motion-during-lung-cancer-radiotherapy
#9
Gareth J Price, Corinne Faivre-Finn, Julia Stratford, Sheena Chauhan, Michelle Bewley, Laura Clarke, Corinne N Johnson, Christopher J Moore
INTRODUCTION: Optical surface measurement devices are a maturing technology in radiotherapy. The challenge for such devices is to demonstrate how they can improve clinical care. We present results from a phase 1 clinical trial designed to test the hypothesis that if presented with live data from a novel optical measurement device, showing their deviation from an ideal radiotherapy treatment position, patients will be able to better control their motion and increase their geometrical conformance...
August 7, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28779935/the-hypotensive-effect-of-yoga-s-breathing-exercises-a-systematic-review
#10
REVIEW
Jeniffer Z Brandani, Julio Mizuno, Emmanuel G Ciolac, Henrique L Monteiro
The aim of this review was to evaluate the effect of pranayama (Yoga's breathing exercises) on BP and its applicability in the treatment of hypertension. Thirteen trials, assessing acute (eight studies) and chronic (five studies) BP response to pranayama were included. Significant BP reductions after pranayama were found in both acute (2-10 mmHg mean SBP reduction, N = 5 studies; 1 mmHg mean DBP reduction, N = 1 study) and chronic studies (4-21 mmHg mean SBP reduction, N = 3 studies; 4-7 mmHg mean DBP reduction, N = 2 studies)...
August 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/28777017/how-to-take-arms-against-central-apneas-in-heart-failure
#11
Chiara Borrelli, Alberto Aimo, Gianluca Mirizzi, Claudio Passino, Giuseppe Vergaro, Michele Emdin, Alberto Giannoni
Introduction Despite being a risk mediator in several observational studies, central apneas are currently orphan of treatment in heart failure. After the neutral effects on survival of two randomized controlled trials (RCTs) based on the use of positive airway pressure (the CANPAP and SERVE-HF trials), two alternative hypotheses have been formulated: 1) Periodic breathing/Cheyne-Stokes respiration (PB/CSR) in HF is protective. Indeed, the Naughton's hypothesis assumes that hyperventilation leads to increased cardiac output, lung volume, oxygen storage and reduced muscle sympathetic nerve activity and central apnea to respiratory muscle rest and hypoxia-induced erythropoiesis...
August 4, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28775244/exhaled-breath-condensate-as-a-potential-biomarker-tool-for-idiopathic-pulmonary-fibrosis-a-pilot-study
#12
Barbara Rindlisbacher, Carina Strebel, Sabina A Guler, Attila Kollar, Thomas K Geiser, Georg Martin Fiedler, Alexander Benedikt Leichtle, Cedric Bovet, Manuela Funke
Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with poor survival. There is an urgent need to better diagnose and monitor IPF patients as new treatments are now available which slow down disease progression. Exhaled breath condensate (EBC) is easily and non-invasively collected, but analysis of potential biomarkers is difficult due to low concentrations and methodological limitations. We now used a non-targeted metabolomics approach to identify further discriminatory metabolic profiles that distinguish IPF patients from controls...
August 4, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28774733/current-child-but-not-maternal-snoring-is-bi-directionally-related-to-adiposity-and-cardiometabolic-risk-markers-a-cross-sectional-and-a-prospective-cohort-analysis
#13
Olivia M Farr, Sheryl L Rifas-Shiman, Emily Oken, Elsie M Taveras, Christos S Mantzoros
PURPOSE: Obstructive sleep apnea (OSA), typically manifested as snoring, is closely associated with obesity. However, the directionality of associations of OSA with cardiometabolic risk markers is unclear, as obesity increases risk for OSA, and OSA results in excess weight gain and its metabolic consequences. Less is known about how obesity and OSA may relate in children and adolescents and whether maternal OSA may influence the development of obesity and cardiometabolic dysfunction in offspring...
June 29, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28767523/respiratory-mechanical-and-cardiorespiratory-consequences-of-cycling-with-aerobars
#14
Jesse M Charlton, Andrew H Ramsook, Reid A Mitchell, Michael A Hunt, Joseph H Puyat, Jordan A Guenette
PURPOSE: Aerobars place a cyclist in a position where the trunk is flexed forward and the elbows are close to the midline of the body. This position is known to improve cycling aerodynamics and time trial race performance compared to upright cycling positions. However, the aggressive nature of this position may have important cardiorespiratory and metabolic consequences. The purpose of this investigation was to examine the respiratory mechanical, ventilatory, metabolic, and sensory consequences of cycling while using aerobars during laboratory based cycling...
July 31, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28764300/effect-of-pranayama-on-ppar-%C3%AE-nf-%C3%AE%C2%BAb-expressions-and-red-complex-microorganisms-in-patients-with-chronic-periodontitis-a-clinical-trial
#15
Jaideep Mahendra, Little Mahendra, R Ananthalakshmi, Prathahini S Parthiban, Sandhya Cherukuri, Mohammed Junaid
INTRODUCTION: Sudarshankriya pranayama is the control of breathing movements to regulate the energy flow throughout the body, which has shown to positively affect immune function, autonomic nervous system and psychologic-neuro pathways. The practice of pranayama has been proven to show several benefits such as reduction in stress levels, relieves anxiety and depression, increase in antioxidant levels, reduces insulin resistance and improves respiratory function. AIM: The objective of the study was to evaluate the levels of Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ), Nuclear Factor-Kappa B (NF-κB) and the presence of Red Complex Microorganisms (RCM) such as Treponema denticola, Porphyromonas gingivalis and Tannerella forsythia in the subgingivalpl aque samples of chronic periodontitis subjects before and after intervention with pranayama as an adjunct to Scaling and Root Planing (SRP)...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28763464/efficacy-of-antibiotherapy-for-treating-flatus-incontinence-associated-with-small-intestinal-bacterial-overgrowth-a-pilot-randomized-trial
#16
Chloé Melchior, Guillaume Gourcerol, Valérie Bridoux, Philippe Ducrotté, Jean-François Quinton, Anne-Marie Leroi
AIM: An increase in intestinal gas production due to small intestinal bowel overgrowth (SIBO) is a contributing factor for flatus incontinence. The aims of our study were to assess the efficacy of metronidazole in a select population of patients with flatus incontinence associated with SIBO and to compare its efficacy with that of a combination of simethicone and activated charcoal (SC; Carbosylane) in randomized experimental arms. METHODS: Adult patients suffering from flatus incontinence associated with SIBO diagnosed by a glucose breath test were enrolled in the study...
2017: PloS One
https://www.readbyqxmd.com/read/28763262/guidelines-for-teaching-yoga-to-women-with-breast-cancer-related-lymphoedema-an-evidence-based-approach
#17
Annette Loudon, Tony Barnett, Andrew D Williams, Denis Visentin, Maarten A Immink, Neil Piller
Breast cancer-related lymphoedema (BCRL) is a chronic condition that requires lifelong management to prevent the condition worsening and to reduce the threat of infection. Women are affected in all domains of their life. As a holistic practice, yoga may be of benefit by reducing both the physical and psychosocial effects of lymphoedema. Women with BCRL are attending yoga classes in increasing numbers, so it is essential that yoga be based on principles that ensure lymphoedema is controlled and not exacerbated...
August 1, 2017: International Journal of Yoga Therapy
https://www.readbyqxmd.com/read/28762892/physiological-response-to-firefighting-activities-of-various-work-cycles-using-extended-duration-and-prototype-scba
#18
Richard M Kesler, Ipek Ensari, Rachel E Klarenc, Robert W Motl, Elizabeth T Hsiao-Wecksler, Karl S Rosengren, Bo Fernhall, Denise L Smith, Gavin P Horn
Firefighters'self-contained breathing apparatus (SCBAs) protect the respiratory system during firefightingbut increases the physiological burden. Extended duration SCBA (>30min) have increased air supply, increasing the duration of firefighting work cycles. To examine the effects of SCBAconfigurationand work cycle (length and rest), 30firefighterscompleted seven trials using different SCBAand one or two bouts of simulated firefighting following work cycles common in the United States. Heart rate, core temperature, oxygen consumption, work output, and self-reported perceptions were recorded during all activities...
August 1, 2017: Ergonomics
https://www.readbyqxmd.com/read/28762565/influence-of-lung-volume-on-the-interaction-between-cardiac-output-and-cerebrovascular-regulation-during-extreme-apnoea
#19
Mike Stembridge, Ryan L Hoiland, Anthony R Bain, Otto F Barak, Ivan Drvis, David B MacLeod, Douglas M MacLeod, Dennis Madden, Tonci Batinic, Peter O'Donoghue, Rob Shave, Zeljko Dujic, Philip N Ainslie
We investigated the role of lung volume-induced changes in cardiac output (Q̇) on cerebrovascular regulation during prolonged apnoea. Fifteen elite apnoea divers (1F; 185 ± 7 cm, 82 ± 12 kg, 29 ± 7 years) attended the laboratory on two separate occasions and completed maximal breath-holds at total lung capacity (TLC) and functional residual capacity (FRC) to elicit disparate cardiovascular responses. Mean arterial pressure (MAP), internal jugular venous pressure (IJVP) and arterial blood gases were measured via cannulation, global cerebral blood flow (gCBF) was quantified by ultrasound and cardiac output via photoplethysmography...
August 1, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28760461/effect-of-dead-space-on-breathing-stability-at-exercise-in-hypoxia
#20
Eric Hermand, François J Lhuissier, Jean-Paul Richalet
Recent studies have shown that normal subjects exhibit periodic breathing when submitted to concomitant environmental (hypoxia) and physiological (exercise) stresses. A mathematical model including mass balance equations confirmed the short period of ventilatory oscillations and pointed out an important role of dead space in the genesis of these phenomena. Ten healthy subjects performed mild exercise on a cycloergometer in different conditions: rest/exercise, normoxia/hypoxia and no added dead space/added dead space (aDS)...
July 29, 2017: Respiratory Physiology & Neurobiology
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