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https://www.readbyqxmd.com/read/28089172/metal-oxide-nanoparticles-as-antimicrobial-agents-a-promise-for-the-future
#1
REVIEW
Azhwar Raghunath, Ekambaram Perumal
Microbial infectious diseases are a global threat to human health. Excess and improper use of antibiotics has created antimicrobial-resistant microbes that can defy clinical treatment. The hunt for safe and alternate antimicrobial agents is on in order to overcome such resistant micro-organisms, and the birth of nanotechnology offers promise to combat infectious organisms. Over the past two decades, metal oxide nanoparticles (MeO-NPs) have become an attractive alternative source to combat microbes that are highly resistant to various classes of antibiotics...
January 3, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28067350/enzyme-responsive-reporter-molecules-for-selective-localization-and-fluorescence-imaging-of-pathogenic-biofilms
#2
Junxin Aw, Frances Widjaja, Yichen Ding, Jing Mu, Yang Liang, Bengang Xing
Pathogenic bacteria and their biofilm formation are responsible for a broad spectrum of microbial infections. A novel enzyme-responsive reporter molecule (ERM-1), which can specifically recognize AmpC β-lactamase (Bla) in drug resistant bacteria, has been developed to enable the selective localization of biofilms.
January 9, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28061852/the-occurrence-of-esbl-producing-escherichia-coli-carrying-aminoglycoside-resistance-genes-in-urinary-tract-infections-in-saudi-arabia
#3
Essam J Alyamani, Anamil M Khiyami, Rayan Y Booq, Majed A Majrashi, Fayez S Bahwerth, Elena Rechkina
BACKGROUND: The infection and prevalence of extended-spectrum β-lactamases (ESBLs) is a worldwide problem, and the presence of ESBLs varies between countries. In this study, we investigated the occurrence of plasmid-mediated ESBL/AmpC/carbapenemase/aminoglycoside resistance gene expression in Escherichia coli using phenotypic and genotypic techniques. METHODS: A total of 58 E. coli isolates were collected from hospitals in the city of Makkah and screened for the production of ESBL/AmpC/carbapenemase/aminoglycoside resistance genes...
January 6, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28054994/synthesis-of-new-nitrofluoroquinolone-derivatives-with-novel-anti-microbial-properties-against-metronidazole-resistant-h-pylori
#4
Luay Abu-Qatouseh, Mohammad Abu-Sini, Amal Mayyas, Yusuf Al-Hiari, Rula Darwish, Talal Aburjai
One of the major therapeutic approaches to preventing relapse and accelerating the healing of duodenal and gastric ulcers is the eradication of Helicobacter pylori. Due to the emergence of antibiotic resistance among clinical strains of H. pylori, alternative approaches using newly discovered antimicrobial agents in combination with the standard regimens for the treatment of H. pylori are increasingly needed. The purpose of the present study was to investigate the effect of newly synthesized 8-nitroflouroqunolone derivatives when used either alone or when combined with metronidazole against metronidazole-resistant H...
January 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28044296/microfluidic-based-bacteria-isolation-from-whole-blood-for-diagnostics-of-blood-stream-infection
#5
Sergey Zelenin, Harisha Ramachandraiah, Asim Faridi, Aman Russom
Bacterial blood stream infection (BSI) potentially leads to life-threatening clinical conditions and medical emergencies such as severe sepsis, septic shock, and multi organ failure syndrome. Blood culturing is currently the gold standard for the identification of microorganisms and, although it has been automated over the decade, the process still requires 24-72 h to complete. This long turnaround time, especially for the identification of antimicrobial resistance, is driving the development of rapid molecular diagnostic methods...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28042865/the-role-of-natural-products-in-drug-discovery-and-development-against-neglected-tropical-diseases
#6
REVIEW
Peter Mubanga Cheuka, Godfrey Mayoka, Peggoty Mutai, Kelly Chibale
Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect more than 1 billion people annually, including 875 million children in developing economies. These diseases are also responsible for over 500,000 deaths per year and are characterized by long-term disability and severe pain. The impact of the combined NTDs closely rivals that of malaria and tuberculosis. Current treatment options are associated with various limitations including widespread drug resistance, severe adverse effects, lengthy treatment duration, unfavorable toxicity profiles, and complicated drug administration procedures...
December 31, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28035988/antibiotic-resistant-superbugs-assessment-of-the-interrelationship-of-occurrence-in-clinical-settings-and-environmental-niches
#7
REVIEW
Anthony Ayodeji Adegoke, Adekunle Christopher Faleye, Gulshan Singh, Thor Axel Stenström
The increasing threat to global health posed by antibiotic resistance remains of serious concern. Human health remains at higher risk due to several reported therapeutic failures to many life threatening drug resistant microbial infections. The resultant effects have been prolonged hospital stay, higher cost of alternative therapy, increased mortality, etc. This opinionated review considers the two main concerns in integrated human health risk assessment (i.e., residual antibiotics and antibiotic resistant genes) in various compartments of human environment, as well as clinical dynamics associated with the development and transfer of antibiotic resistance (AR)...
December 27, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28035685/a-medicinal-herb-cassia-alata-attenuates-quorum-sensing-in-chromobacterium-violaceum-and-pseudomonas-aeruginosa
#8
P D Rekha, H S Vasavi, C Vipin, K Saptami, A B Arun
Quorum sensing (QS) has been shown to play a crucial role in the pathogenesis in many bacteria and attenuation of QS is one of the targets of antimicrobial therapy with particular interest in combating drug resistance. This study reports the QS inhibitory activity of metabolites from Cassia alata L. (Ca. alata), an important medicinal herb widely used in the treatment of microbial infections. For investigating the QS inhibition (QSI) potential of Ca. alata L., initially, metabolites of the leaves extracted using ethanol were tested against biosensor strain Chromobacterium violaceum CV026 and C...
December 30, 2016: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28032341/nlrp3-inflammasome-mediates-il-1%C3%AE-production-in-immune-cells-in-response-to-acinetobacter-baumannii-and-contributes-to-pulmonary-inflammation-in-mice
#9
Min-Jung Kang, Sung-Gang Jo, Dong-Jae Kim, Jong-Hwan Park
Acinetobacter baumannii is a multi-drug resistant gram-negative bacteria, and infection with this organism is one of the major causes of mortality in intensive care units. Inflammasomes are multiprotein oligomers that include caspase-1, and their activation is required for maturation of IL-1β. Inflammasome signaling is involved in host defenses against various microbial infection, but the precise mechanism by which A. baumannii activates inflammasomes and the roles of relevant signals in host defense against pulmonary A...
December 29, 2016: Immunology
https://www.readbyqxmd.com/read/28011434/facile-and-green-synthesis-of-phytochemicals-capped-platinum-nanoparticles-and-in-vitro-their-superior-antibacterial-activity
#10
Kamran Tahir, Sadia Nazir, Aftab Ahmad, Baoshan Li, Arif Ullah Khan, Zia Ul Haq Khan, Faheem Ullah Khan, Qudrat Ullah Khan, Abrar Khan, Aziz Ur Rahman
The increase in the severe infectious diseases and resistance of the majority of the bacterial pathogens to the available drug is a serious problem now a day. In order to overcome this problem it is necessary to develop new therapeutic agents which are non-toxic and more effective to inhibit these microbial pathogens. For this purpose the plant extract of highly active medicinal plant, Taraxacum laevigatum was used for the synthesis of platinum nanoparticles (PtNPs) to enhance its bio-activities. The surface plasmon resonance peak appeared at 283nm clearly represent the formation of PtNPs...
January 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28007546/biopolymeric-self-assembled-nanoparticles-for-enhanced-antibacterial-activity-of-ag-based-compounds
#11
Dhanya Dhanyalayam, Luca Scrivano, Ortensia Ilaria Parisi, Maria Stefania Sinicropi, Antonietta Fazio, Carmela Saturnino, Maria Rosaria Plutino, Francesca Di Cristo, Francesco Puoci, Anna Rita Cappello, Pasquale Longo
Microbial infections still remain one of the main issues for human health. The rapid development of resistance towards the most common antimicrobial drugs in bacteria represents today a challenge in the infections management. In the present work we have investigated the antibacterial activity of a group of compounds, namely silver N-heterocyclic carbene complexes, against a broad spectrum of bacteria. For the most promising compound, a biopolymeric nanocarrier has been developed, in order to potentiate the metal complex activity against both Gram +ve and Gram -ve...
December 19, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28001222/secondary-bacterial-isolates-from-previously-untreated-buruli-ulcer-lesions-and-their-antibiotic-susceptibility-patterns-in-southern-nigeria
#12
Moses Chibueze Anyim, Anthony Obiamaka Meka, Joseph Ngozi Chukwu, Charles Chukwunalu Nwafor, Daniel Chukwunweolu Oshi, Nelson Okechukwu Madichie, Ngozi Ekeke, Chukwuka Alphonsus, Obinna Mbah, Chinenye Nwaekpe, Martin Njoku, Dare Fakiyesi, Vitalis Ulodiaku, Ignatius Ejiofor, Adeniyi Hakeem Bisiriyu, Kingsley Nnanna Ukwaja
INTRODUCTION: Mycolactones, secreted by Mycobacterium ulcerans, were previously believed to prevent super infection in Buruli ulcer lesions. However, little is known about secondary bacterial infections in these lesions. This study evaluated contaminating bacterial flora and their antibiotic susceptibility patterns in cases of previously untreated Buruli ulcer disease from three states in Southern Nigeria. METHODS: A prospective analysis was conducted between January and June of 2015 using wound swabs from eligible patients with Buruli ulcer disease, confirmed by quantitative-polymerase chain reaction, with active ulcers...
November 2016: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/27999566/isolation-screening-and-identification-of-novel-isolates-of-actinomycetes-from-india-for-antimicrobial-applications
#13
Vineeta Singh, Shafiul Haque, Harshita Singh, Jyoti Verma, Kumari Vibha, Rajbir Singh, Arshad Jawed, C K M Tripathi
The search for novel bioactive compounds from the natural environment has rapidly been gaining momentum with the increase in multi-drug resistant (MDR) pathogens. In the present study, the antimicrobial potential of novel actinomycetes has been evaluated by initial screening of six soil samples. Primary and secondary screening was performed against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Candida albicans, Candida tropicalis, Trichophyton rubrum, and other MDR bacterial and fungal test strains, thirteen active isolates were selected for further study...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27996032/targeting-bacterial-adherence-inhibits-multidrug-resistant-pseudomonas-aeruginosa-infection-following-burn-injury
#14
Ryan M Huebinger, Daniel H Stones, Marcela de Souza Santos, Deborah L Carlson, Juquan Song, Diana Pereira Vaz, Emma Keen, Steven E Wolf, Kim Orth, Anne Marie Krachler
Classical antimicrobial drugs target proliferation and therefore place microbes under extreme selective pressure to evolve resistance. Alternative drugs that target bacterial virulence without impacting survival directly offer an attractive solution to this problem, but to date few such molecules have been discovered. We previously discovered a widespread group of bacterial adhesins, termed Multivalent Adhesion Molecules (MAMs) that are essential for initial binding of bacteria to host tissues and virulence...
December 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27994583/beyond-traditional-antimicrobials-a-caenorhabditis-elegans-model-for-discovery-of-novel-anti-infectives
#15
REVIEW
Cin Kong, Su-Anne Eng, Mei-Perng Lim, Sheila Nathan
The spread of antibiotic resistance amongst bacterial pathogens has led to an urgent need for new antimicrobial compounds with novel modes of action that minimize the potential for drug resistance. To date, the development of new antimicrobial drugs is still lagging far behind the rising demand, partly owing to the absence of an effective screening platform. Over the last decade, the nematode Caenorhabditis elegans has been incorporated as a whole animal screening platform for antimicrobials. This development is taking advantage of the vast knowledge on worm physiology and how it interacts with bacterial and fungal pathogens...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27992105/cyclobutanone-analogues-of-%C3%AE-lactam-antibiotics-%C3%AE-lactamase-inhibitors-with-untapped-potential
#16
Prarthana Devi, Peter J Rutledge
β-Lactam antibiotics have been used for many years to treat bacterial infections. However the effective treatment of an increasing range of microbial infections is threatened by bacterial resistance to β-lactams: the prolonged, widespread and at times reckless use of these drugs has spawned widespread resistance, which renders them ineffective against many bacterial strains. The cyclobutanone ring system is isosteric with β-lactam: in cyclobutanone analogues, the eponymous cyclic amide is replaced with an all-carbon ring, the amide N substituted by a tertiary C-H α to a ketone...
December 19, 2016: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27987773/scaffolds-of-hydroxyl-apatite-nanoparticles-disseminated-in-1-6-diisocyanatohexane-extended-poly-1-4-butylene-succinate-poly-methyl-methacrylate-for-bone-tissue-engineering
#17
Kulwinder Kaur, K J Singh, Vikas Anand, Gaurav Bhatia, Raminderjit Kaur, Manpreet Kaur, Lovedeep Nim, Daljit Singh Arora
Poly(1, 4-butyl succinate) extended 1, 6-diisocyanatohexane (PBSu-DCH) polymers and Polymethylmethacrylate (PMMA) scaffolds decorated with nano hydroxyl apatite have been prepared and characterized for regeneration of bone in cranio-maxillofacial region. Synthesized scaffolds revealed good response in bone regeneration and excellent cell viability in comparison to commercial available glass plate, which lead to better proliferation of MG-63 cell lines. Additionally, they demonstrate high porosity and excellent water retention ability...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27986722/detection-of-eskape-bacterial-pathogens-at-the-point-of-care-using-isothermal-dna-based-assays-in-a-portable-de-gas-microfluidic-diagnostic-assay-platform
#18
Lars D Renner, Jindong Zan, Linda I Hu, Manuel Martinez, Pedro J Resto, Adam C Siegel, Clint Torres, Sara B Hall, Tom R Slezak, Tuan H Nguyen, Douglas B Weibel
: An estimated 1.5B microbial infections occur globally each year and result in ∼4.6M deaths. A technology gap associated with commercially available diagnostic tests in remote and underdeveloped regions prevents timely pathogen identification for effective antibiotic chemotherapies for infected patients. The result is a trial-and-error approach that is limited in effectiveness and increases risk for patients while contributing to antimicrobial drug resistance and reduces the lifetime of antibiotics...
December 16, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27983597/antibiofilm-activity-of-plant-polyphenols
#19
REVIEW
Lívia Slobodníková, Silvia Fialová, Katarína Rendeková, Ján Kováč, Pavel Mučaji
In the history of human medicine, antibiotics represent epochal examples of medical progress. However, with an approaching antibiotic crisis due to the emergence and extensive spread of antimicrobial resistance among bacterial agents, as well as to increasing number of patients with chronic and recalcitrant bacterial biofilm-associated infections, the naturally occurring molecules may become new sources of antibacterial and antibiofilm drugs for clinical usage. Polyphenols represent a class of plant natural products which are important in plant defense against microbial pathogens...
December 13, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27980020/identification%C3%A2-of%C3%A2-ly2%C3%A2-members%C3%A2-as%C3%A2-novel%C3%A2-antimicrobial%C3%A2-peptides%C3%A2-from%C3%A2-zebrafish%C3%A2-danio%C3%A2-rerio
#20
Xuemin Liu, Xuwen Cao, Su Wang, Guangdong Ji, Shicui Zhang, Hongyan Li
The emergence of multi-drug resistant (MDR) microbes caused by overuse of antibiotics leads to urgent demands for novel antibiotics exploration. Our recent data showed that Ly2.1-3 (a novel Ly6 gene cluster) were proteins with cationic nature and rich in cysteines content, that are characteristics of antimicrobial peptides (AMPs), and their expression were all significantly up-regulated after challenge with LPS. These strongly suggested that Ly2.1-3 are potential AMPs, but firm evidences are lacking. Here we clearly showed that the recombinant proteins of Ly2...
December 15, 2016: Bioscience Reports
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