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https://www.readbyqxmd.com/read/28220186/efficient-gene-targeting-in-non-homologous-end-joining-deficient-lipomyces-starkeyi-strains
#1
Yoshifumi Oguro, Harutake Yamazaki, Satoshi Ara, Yosuke Shida, Wataru Ogasawara, Masamichi Takagi, Hiroaki Takaku
Microbial lipids are sustainable feedstock for the production of oleochemicals and biodiesel. Oleaginous yeasts have recently been proposed as alternative lipid producers to plants and animals to promote sustainability in the chemical and fuel industries. The oleaginous yeast Lipomyces starkeyi has great industrial potential as an excellent lipid producer. However, improvement of its lipid productivity is essential for the cost-effective production of oleochemicals and fuels. Genetic and metabolic engineering of L...
February 20, 2017: Current Genetics
https://www.readbyqxmd.com/read/28218694/antibacterial%C3%A2-activities%C3%A2-of%C3%A2-bacteria%C3%A2-isolated%C3%A2-from%C3%A2-the%C3%A2-marine%C3%A2-sponges%C3%A2-isodictya%C3%A2-compressa%C3%A2-and%C3%A2-higginsia%C3%A2-bidentifera%C3%A2-collected%C3%A2-from%C3%A2-algoa%C3%A2-bay-%C3%A2-south%C3%A2-africa
#2
Relebohile Matthew Matobole, Leonardo Joaquim van Zyl, Shirley Parker-Nance, Michael T Davies-Coleman, Marla Trindade
Due to the rise in multi-drug resistant pathogens and other diseases, there is renewed interest in marine sponge endosymbionts as a rich source of natural products (NPs). The South African marine environment is rich in marine biota that remains largely unexplored and may represent an important source for the discovery of novel NPs. We first investigated the bacterial diversity associated with five South African marine sponges, whose microbial populations had not previously been investigated, and select the two sponges (Isodictya compressa and Higginsia bidentifera) with highest species richness to culture bacteria...
February 17, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28202116/-pathogens-of-infections-in-the-induction-period-of-childhood-acute-lymphoblastic-leukemia-and-drug-resistance-of-isolated-strains
#3
Zai-Sheng Chen, Ling Zheng, Yi-Qiao Chen, Jing-Hui Yang, Jian Li
OBJECTIVE: To investigate the infections occurring in the induction period of childhood acute lymphoblastic leukemia (ALL), the pathogens of the infections, and drug resistance of isolated strains. METHODS: A retrospective analysis was performed for the clinical data of 130 children with newly-diagnosed childhood ALL. Infections occurring during the induction chemotherapy, pathogenic strains, and drug-resistance spectrum were analyzed. RESULTS: The incidence rate of clinical infection and/or microbial infection reached 76...
February 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28192223/emergence-of-multi-drug-resistance-among-soil-bacteria-exposing-to-insecticides
#4
Kirubakaran Rangasamy, Murugan Athiappan, Natarajan Devarajan, Javid A Parray
Impacts of pesticide exposure on the soil microbial flora and cross resistance to antibiotics have not been well documented. Development of antibiotic resistance is a common issue among soil bacteria which are exposing to pesticides continuously at sub-lethal concentration. The present study was focused to evaluate the correlation between pesticide exposures and evolution of multi drug resistance among isolates collected from soil applied with insecticides. Twenty five insecticide (Monochrotophos) degrading bacteria were isolated from contaminated agricultural soil...
February 9, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28174312/selective-whole-genome-amplification-is-a-robust-method-that-enables-scalable-whole-genome-sequencing-of-plasmodium-vivax-from-unprocessed-clinical-samples
#5
Annie N Cowell, Dorothy E Loy, Sesh A Sundararaman, Hugo Valdivia, Kathleen Fisch, Andres G Lescano, G Christian Baldeviano, Salomon Durand, Vince Gerbasi, Colin J Sutherland, Debbie Nolder, Joseph M Vinetz, Beatrice H Hahn, Elizabeth A Winzeler
: Whole-genome sequencing (WGS) of microbial pathogens from clinical samples is a highly sensitive tool used to gain a deeper understanding of the biology, epidemiology, and drug resistance mechanisms of many infections. However, WGS of organisms which exhibit low densities in their hosts is challenging due to high levels of host genomic DNA (gDNA), which leads to very low coverage of the microbial genome. WGS of Plasmodium vivax, the most widely distributed form of malaria, is especially difficult because of low parasite densities and the lack of an ex vivo culture system...
February 7, 2017: MBio
https://www.readbyqxmd.com/read/28138369/distribution-and-drug-susceptibility-of-candida-spp-associated-with-female-genital-tract-infection-chongqing-china
#6
Xiaodong Luo, Xiaojing Dong, Zhi Pen
BACKGROUND: Vulvovaginal candidiasis is defined as vulvovaginitis associated with vaginal carriage of Candida spp. and is a common problem with a high rate of morbidity. OBJECTIVES: To investigate the distribution of Candida spp. and evaluate the corresponding antifungal susceptibility in women with genital tract infection in Chongqing, southwestern China. PATIENTS AND METHODS: Samples (n = 2.129) were obtained from female patients with symptoms of genital tract infection...
October 2016: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/28137509/plasmid-borne-carbapenem-hydrolyzing-class-d-%C3%AE-lactamases-chdls-and-adeabc-efflux-pump-conferring-carbapenem-tigecycline-resistance-among-acinetobacter-baumannii-isolates-harboring-tnabars
#7
Mohammad Savari, Alireza Ekrami, Saeed Shoja, Abbas Bahador
Here we studied the prevalence and mechanisms of simultaneous resistance to carbapenem and tigecycline and accumulation of resistance determinants reservoirs in genome of Acinetobacter baumannii (A. baumannii) clinical isolates. Susceptibility of the isolates were measured to 18 antimicrobial agents. Genetic diversity of the microbial population was determined using the International Clonal lineage typing (IC typing), multiple locus VNTR analysis (MLVA) and plasmid profiling methods. To detect the AbaRs, Carbapenem-Hydrolyzing Class D β-Lactamases (CHDLs) genes, AdeABC efflux pump genes and resistance determinants, PCR was used...
March 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28127894/identification-and-bioactive-potential-of-marine-microorganisms-from-selected-florida-coastal-areas
#8
Anna Christensen, Glenroy D A Martin
The ocean, with its rich untapped chemical biodiversity, continues to serve as a source of potentially new therapeutic agents. The evaluation of the diversity of cultivable microorganisms from the marine sponge Halichondria panicea and ocean sediment samples were examined and their potential as sources of antimicrobial and antiproliferative agents were investigated. The marine sponge and sediments were collected at different depths (0.9-6 meters) and locations in Florida, including Florida Keys, Port St. Joe in Pensacola, Pensacola Bay, Pensacola Beach, and Fort Pickens...
January 26, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28118803/meta-analysis-of-the-efficacy-of-moxifloxacin-in-treating-mycoplasma-genitalium-infection
#9
Yang Li, Wen-Jing Le, Sai Li, Yu-Ping Cao, Xiao-Hong Su
Mycoplasma genitalium is an important pathogen that is transmitted through sexual contact. For patients diagnosed with M. genitalium infection, the current guidelines recommend 1 g of azithromycin as the first-line treatment. Moxifloxacin is used as a second-line drug due to its remarkable efficacy; however, increased use of moxifloxacin to treat M. genitalium infections has caused the emergence of cases of moxifloxacin treatment failure. This meta-analysis aims to estimate the treatment efficacy of moxifloxacin for M...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28117944/infection-in-organ-transplantation
#10
Jay A Fishman
The prevention, diagnosis and management of infectious disease in transplantation are major contributors to improved outcomes in organ transplantation. The risk of serious infections in organ recipients is determined largely by the interaction between the patient's epidemiological exposures and net state of immune suppression. In organ recipients, there is a significant incidence of drug toxicity and a propensity for drug interactions with immunosuppressive agents used to maintain graft function. Thus, every effort must be made to establish specific microbiologic diagnoses to optimize therapy...
January 24, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28116629/toxicity-and-biodegradation-of-ibuprofen-by-bacillus-thuringiensis-b1-2015b
#11
Ariel Marchlewicz, Urszula Guzik, Katarzyna Hupert-Kocurek, Agnieszka Nowak, Sylwia Wilczyńska, Danuta Wojcieszyńska
In recent years, the increased intake of ibuprofen has resulted in the presence of the drug in the environment. This work presents results of a study on degradation of ibuprofen at 25 mg L(-1) in the presence of glucose, as an additional carbon source by Bacillus thuringiensis B1(2015b). In the cometabolic system, the maximum specific growth rate of the bacterial strain was 0.07 ± 0.01 mg mL(-1) h(-1) and K sμ 0.27 ± 0.15 mg L(-1). The maximum specific ibuprofen removal rate and the value of the half-saturation constant were q max = 0...
January 23, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28114348/polymicrobial-ventilator-associated-pneumonia-fighting-in-vitro-candida-albicans-pseudomonas-aeruginosa-biofilms-with-antifungal-antibacterial-combination-therapy
#12
Maria E Rodrigues, Susana P Lopes, Cláudia R Pereira, Nuno F Azevedo, Anália Lourenço, Mariana Henriques, Maria O Pereira
The polymicrobial nature of ventilator-associated pneumonia (VAP) is now evident, with mixed bacterial-fungal biofilms colonizing the VAP endotracheal tube (ETT) surface. The microbial interplay within this infection may contribute for enhanced pathogenesis and exert impact towards antimicrobial therapy. Consequently, the high mortality/morbidity rates associated to VAP and the worldwide increase in antibiotic resistance has promoted the search for novel therapeutic strategies to fight VAP polymicrobial infections...
2017: PloS One
https://www.readbyqxmd.com/read/28107379/experimental-and-in-silico-investigation-of-anti-microbial-activity-of-1-chloro-2-isocyanatoethane-derivatives-of-thiomorpholine-piperazine-and-morpholine
#13
Charles O Nwuche, Oguejiofo T Ujam, Akachukwu Ibezim, Ifeoma B Ujam
The Antibiogram properties of 1-chloro-2-isocyanatoethane derivatives of thiomorpholine (CTC), piperazine (CPC) and morpholine (CMC) were evaluated by the approved agar well diffusion, the minimum inhibitory concentration (MIC) and in silico techniques. A total of fourteen microbial cultures consisting of ten bacteria and four yeast strains were used in the biological study while affinity of the compounds for DNA gyrase, a validated antibacterial drug target, was investigated by docking method. Results indicate that both thiomorpholine and piperazine had zero activity against the Gram negative organisms tested...
2017: PloS One
https://www.readbyqxmd.com/read/28096686/peptide-consensus-sequence-determination-for-the-enhancement-of-the-antimicrobial-activity-and-selectivity-of-antimicrobial-peptides
#14
Ammar Almaaytah, Ya'u Ajingi, Ahmad Abualhaijaa, Shadi Tarazi, Nizar Alshar'i, Qosay Al-Balas
The rise of multidrug-resistant bacteria is causing a serious threat to the world's human population. Recent reports have identified bacterial strains displaying pan drug resistance against antibiotics and generating fears among medical health specialists that humanity is on the dawn of entering a post-antibiotics era. Global research is currently focused on expanding the lifetime of current antibiotics and the development of new antimicrobial agents to tackle the problem of antimicrobial resistance. In the present study, we designed a novel consensus peptide named "Pepcon" through peptide consensus sequence determination among members of a highly homologous group of scorpion antimicrobial peptides...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28089172/metal-oxide-nanoparticles-as-antimicrobial-agents-a-promise-for-the-future
#15
REVIEW
Azhwar Raghunath, Ekambaram Perumal
Microbial infectious diseases are a global threat to human health. Excess and improper use of antibiotics has created antimicrobial-resistant microbes that can defy clinical treatment. The hunt for safe and alternate antimicrobial agents is on in order to overcome such resistant micro-organisms, and the birth of nanotechnology offers promise to combat infectious organisms. Over the past two decades, metal oxide nanoparticles (MeO-NPs) have become an attractive alternative source to combat microbes that are highly resistant to various classes of antibiotics...
January 3, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28067350/enzyme-responsive-reporter-molecules-for-selective-localization-and-fluorescence-imaging-of-pathogenic-biofilms
#16
Junxin Aw, Frances Widjaja, Yichen Ding, Jing Mu, Yang Liang, Bengang Xing
Pathogenic bacteria and their biofilm formation are responsible for a broad spectrum of microbial infections. A novel enzyme-responsive reporter molecule (ERM-1), which can specifically recognize AmpC β-lactamase (Bla) in drug resistant bacteria, has been developed to enable the selective localization of biofilms.
January 9, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28061852/the-occurrence-of-esbl-producing-escherichia-coli-carrying-aminoglycoside-resistance-genes-in-urinary-tract-infections-in-saudi-arabia
#17
Essam J Alyamani, Anamil M Khiyami, Rayan Y Booq, Majed A Majrashi, Fayez S Bahwerth, Elena Rechkina
BACKGROUND: The infection and prevalence of extended-spectrum β-lactamases (ESBLs) is a worldwide problem, and the presence of ESBLs varies between countries. In this study, we investigated the occurrence of plasmid-mediated ESBL/AmpC/carbapenemase/aminoglycoside resistance gene expression in Escherichia coli using phenotypic and genotypic techniques. METHODS: A total of 58 E. coli isolates were collected from hospitals in the city of Makkah and screened for the production of ESBL/AmpC/carbapenemase/aminoglycoside resistance genes...
January 6, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28054994/synthesis-of-new-nitrofluoroquinolone-derivatives-with-novel-anti-microbial-properties-against-metronidazole-resistant-h-pylori
#18
Luay Abu-Qatouseh, Mohammad Abu-Sini, Amal Mayyas, Yusuf Al-Hiari, Rula Darwish, Talal Aburjai
One of the major therapeutic approaches to preventing relapse and accelerating the healing of duodenal and gastric ulcers is the eradication of Helicobacter pylori. Due to the emergence of antibiotic resistance among clinical strains of H. pylori, alternative approaches using newly discovered antimicrobial agents in combination with the standard regimens for the treatment of H. pylori are increasingly needed. The purpose of the present study was to investigate the effect of newly synthesized 8-nitroflouroqunolone derivatives when used either alone or when combined with metronidazole against metronidazole-resistant H...
January 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28044296/microfluidic-based-bacteria-isolation-from-whole-blood-for-diagnostics-of-blood-stream-infection
#19
Sergey Zelenin, Harisha Ramachandraiah, Asim Faridi, Aman Russom
Bacterial blood stream infection (BSI) potentially leads to life-threatening clinical conditions and medical emergencies such as severe sepsis, septic shock, and multi organ failure syndrome. Blood culturing is currently the gold standard for the identification of microorganisms and, although it has been automated over the decade, the process still requires 24-72 h to complete. This long turnaround time, especially for the identification of antimicrobial resistance, is driving the development of rapid molecular diagnostic methods...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28042865/the-role-of-natural-products-in-drug-discovery-and-development-against-neglected-tropical-diseases
#20
REVIEW
Peter Mubanga Cheuka, Godfrey Mayoka, Peggoty Mutai, Kelly Chibale
Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect more than 1 billion people annually, including 875 million children in developing economies. These diseases are also responsible for over 500,000 deaths per year and are characterized by long-term disability and severe pain. The impact of the combined NTDs closely rivals that of malaria and tuberculosis. Current treatment options are associated with various limitations including widespread drug resistance, severe adverse effects, lengthy treatment duration, unfavorable toxicity profiles, and complicated drug administration procedures...
December 31, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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