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Drug resistance microbial

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https://www.readbyqxmd.com/read/28423970/recent-advances-on-topical-antimicrobials-for-skin-and-soft-tissue-infections-and-their-safety-concerns
#1
P L Lam, K K H Lee, R S M Wong, G Y M Cheng, Z X Bian, C H Chui, R Gambari
Antimicrobial resistance of disease-related microorganisms is considered a worldwide prevalent and serious issue which increases the failure of treatment outcomes and leads to high mortality. Considering that the increased resistance to systemic antimicrobial therapy often needs of the use of more toxic agents, topical antimicrobial therapy emerges as an attractive route for the treatment of infectious diseases. The topical antimicrobial therapy is based on the absorption of high drug doses in a readily accessible skin surface, resulting in a reduction of microbial proliferation at infected skin sites...
April 19, 2017: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/28418081/assessment-of-biofilm-removal-capacity-of-a-broad-host-range-bacteriophage-jhp-against-pseudomonas-aeruginosa
#2
Muafia Shafique, Iqbal Ahmad Alvi, Zaigham Abbas, Shafiq Ur Rehman
Pseudomonas aeruginosa is an efficient biofilm-dwelling microbial pathogen, associated with nosocomial infections. These biofilm-associated infections are resistant to antibiotics and immune defenses, therefore pose major problem against their treatment. This scenario demands alternative therapeutic regimens, and bacteriophage therapy is one among potential strategies for clinical management of multiple drug resistance. In this investigation, the efficacy of a bacteriophage, JHP, is evaluated to eradicate P...
April 18, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28406077/editorial-old-drugs-%C3%A3-new-perspectives-new-compounds-%C3%A3-old-necessities-focusing-on-combating-microbial-resistance-part-i
#3
EDITORIAL
André L S Santos, Lucimar F Kneipp, Claudia M d'Avila-Levy, Cátia L Sodré, Marta H Branquinha
No abstract text is available yet for this article.
2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28406074/editorial-old-drugs-%C3%A3-new-perspectives-new-compounds-%C3%A3-old-necessities-focusing-on-combating-microbial-resistance-part-ii
#4
EDITORIAL
Andre Luis Souza Dos Santos, Lucimar Ferreira Kneipp, Claudia Masini d'Avila-Levy, Catia Lacerda Sodre, Marta Helena Branquinha
No abstract text is available yet for this article.
2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28403796/riboswitches-as-potential-targets-for-the-development-of-anti-biofilm-drugs
#5
José A Reyes-Darias, Tino Krell
In nature, bacteria can exist as single motile cells or as sessile cellular community, known as microbial biofilms. Bacteria within biofilms are embedded in a self-produced extracellular matrix that makes them more resistant to antibiotic treatment and responses of the host immune system. Microbial biofilms are very important in medicine since they are associated with several human diseases such as dental caries, periodontitis, otitis media, infective endocarditis, infectious kidney stones, osteomyelitis or prostatitis...
April 7, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28399890/imipenem-cilastatin-encapsulated-polymeric-nanoparticles-for-destroying-carbapenem-resistant-bacterial-isolates
#6
Mona I Shaaban, Mohamed A Shaker, Fatma M Mady
BACKGROUND: Carbapenem-resistance is an extremely growing medical threat in antibacterial therapy as the incurable resistant strains easily develop a multi-resistance action to other potent antimicrobial agents. Nonetheless, the protective delivery of current antibiotics using nano-carriers opens a tremendous approach in the antimicrobial therapy, allowing the nano-formulated antibiotics to beat these health threat pathogens. Herein, we encapsulated imipenem into biodegradable polymeric nanoparticles to destroy the imipenem-resistant bacteria and overcome the microbial adhesion and dissemination...
April 11, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28396657/the-activity-of-a-hexameric-m17-metallo-aminopeptidase-is-associated-with-survival-of-mycobacterium-tuberculosis
#7
Andre F Correa, Izabela M D Bastos, David Neves, Andre Kipnis, Ana P Junqueira-Kipnis, Jaime M de Santana
Mycobacterium tuberculosis is one of the most prevalent human pathogens causing millions of deaths in the last years. Moreover, tuberculosis (TB) treatment has become increasingly challenging owing to the emergence of multidrug resistant M. tuberculosis strains. Thus, there is an immediate need for the development of new anti-TB drugs. Proteases appear to be a promising approach and may lead to shortened and effective treatments for drug-resistant TB. Although the M. tuberculosis genome predicts more than 100 genes encoding proteases, only a few of them have been studied...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28389448/drug-resistant-fungus-joins-growing-list-of-microbial-threats
#8
Kate Traynor
No abstract text is available yet for this article.
April 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28384863/comparative-evaluation-of-fosfomycin-activity-with-other-antimicrobial-agents-against-e-coli-isolates-from-urinary-tract-infections
#9
Ahmed Sardar, Sreekanth Reddy Basireddy, Anwar Navaz, Manisha Singh, Vasanti Kabra
INTRODUCTION: Fosfomycin is a broad spectrum anti-microbial agent with activity against various bacterial agents. It is a bactericidal antibiotic which interferes with cell wall synthesis. Fosfomycin is rapidly absorbed orally and majority of the drug is excreted unchanged in urine with very high concentration levels achieved in urine after a single oral dose. Urine levels remain high for prolonged period which makes it a suitable drug in the treatment of Urinary Tract Infections (UTI)...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28361745/short-term-impact-of-a-classical-ketogenic-diet-on-gut-microbiota-in-glut1-deficiency-syndrome-a-3-month-prospective-observational-study
#10
Anna Tagliabue, Cinzia Ferraris, Francesca Uggeri, Claudia Trentani, Simona Bertoli, Valentina de Giorgis, Pierangelo Veggiotti, Marina Elli
BACKGROUND&AIMS: The classical ketogenic diet (KD) is a high-fat, very low-carbohydrate normocaloric diet used for drug-resistant epilepsy and Glucose Transporter 1 Deficiency Syndrome (GLUT1 DS). In animal models, high fat diet induces large alterations in microbiota producing deleterious effects on gut health. We carried out a pilot study on patients treated with KD comparing their microbiota composition before and after three months on the diet. METHODS: Six patients affected by GLUT1 DS were asked to collect fecal samples before and after three months on the diet...
February 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28358034/in-silico-identification-of-potential-inhibitors-targeting-streptococcus-mutans-sortase-a
#11
Hao Luo, Dan-Feng Liang, Min-Yue Bao, Rong Sun, Yuan-Yuan Li, Jian-Zong Li, Xin Wang, Kai-Min Lu, Jin-Ku Bao
Dental caries is one of the most common chronic diseases and is caused by acid fermentation of bacteria adhered to the teeth. Streptococcus mutans (S. mutans) utilizes sortase A (SrtA) to anchor surface proteins to the cell wall and forms a biofilm to facilitate its adhesion to the tooth surface. Some plant natural products, especially several flavonoids, are effective inhibitors of SrtA. However, given the limited number of inhibitors and the development of drug resistance, the discovery of new inhibitors is urgent...
March 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28350247/the-transgenic-zebrafish-display-fluorescence-reflecting-the-expressional-dynamics-of-dihydrofolate-reductase
#12
Wen-Ni Chang, Wan-Yu Chi, Tseng-Ting Kao, Jen-Ning Tsai, Wangta Liu, Shih-Shin Liang, Chien-Chih Chiu, Bing-Hung Chen, Tzu-Fun Fu
Dihydrofolate reductase (DHFR) reduces folic acid and recycles dihydrofolate generated during dTMP biosynthesis to tetrahydrofolate. DHFR is upregulated in rapidly proliferating cells and hence a favored target of antifolate drug against cancers, autoimmune diseases, and microbial infections. However, increased expression of dhfr contributed to the often emerging drug resistance and impeded the therapeutic efficacy of antifolate drugs. Therefore, comprehensive knowledge on the expressional control of dhfr becomes crucial...
March 28, 2017: Zebrafish
https://www.readbyqxmd.com/read/28349345/photodynamic-inactivation-of-paracoccidioides-brasiliensis-helps-the-outcome-of-oral-paracoccidiodomycosis
#13
Letícia F M Dos Santos, Nathália B Melo, Marina L de Carli, Ana Carolina S C Mendes, Giulia Maria A C Bani, Liana M Verinaud, Eva Burger, Gabriel de Oliveira I Moraes, Alessandro A C Pereira, Maísa R L Brigagão, João Adolfo C Hanemann, Felipe F Sperandio
The antifungal drug therapy often employed to treat paracoccidiodomycosis (PCM), an important neglected fungal systemic infection, leads to offensive adverse effects, besides being very long-lasting. In addition, PCM compromises the oral health of patients by leading to oral lesions that are very painful and disabling. In that way, photodynamic therapy (PDT) arises as a new promising adjuvant treatment for inactivating Paracoccidioides brasiliensis (Pb), the responsible fungus for PCM, and also for helping the patients to deal with such debilitating oral lesions...
March 27, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28347339/antibacterial-activity-of-the-stem-bark-of-tieghemella-heckelii-pierre-ex-a-chev-against-methicillin-resistant-staphylococcus-aureus
#14
B G Kipre, N K Guessennd, M W Koné, V Gbonon, J K Coulibaly, M Dosso
BACKGROUND: Tieghemella heckelii (Sapotaceae) is a medicinal plant used in Africa, particularly in Côte d'Ivoire for treating various diseases including infections. Identification of prospective antibacterial compounds from stem bark of this plant as a result of its medicinal virtue, led to screening activity against methicillin resistant bacteria. METHODS: Six extracts (hexane, chloroform, ethyl acetate, ethanol, methanol and sterile distilled water) were prepared and tested on methicillin resistant Staphylococcus aureus (MRSA) using broth microdilution method for activity assessment...
March 27, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28344030/antibacterial-activity-of-medicinal-plants-from-the-physicians-of-myddvai-a-13-th-century-welsh-medical-manuscript
#15
Charles Wagner, Jillian De Gezelle, Maureen Robertson, Keith Robertson, Mickey Wilson, Slavko Komarnytsky
ETHNOPHARMACOLOGICAL RELEVANCE: Antimicrobial drug resistance is a growing threat to global public health. Historical records and herbal texts relating to traditional Celtic medicine indicate an extensive pharmacopeia of plants for treating infections likely caused by microbes. However, a major barrier for successful integration of these remedies into mainstream practice is the current lack of accurate interpretation and scientific validation. MATERIALS AND METHODS: We applied Mobile Discovery approach to the Isle of Arran, Scotland, for in situ targeted screening of 83 out of 138 plants identified in Meddygion Myddvai (a 13(th) century Welsh manuscript) to treat conditions related to microbial infections, and an additional 18 plants from modern ethnobotanical knowledge on the island...
March 24, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28326075/advantages-of-the-silkworm-as-an-animal-model-for-developing-novel-antimicrobial-agents
#16
REVIEW
Suresh Panthee, Atmika Paudel, Hiroshi Hamamoto, Kazuhisa Sekimizu
The demand for novel antibiotics to combat the global spread of multi drug-resistant pathogens continues to grow. Pathogenic bacteria and fungi that cause fatal human infections can also kill silkworms and the infected silkworms can be cured by the same antibiotics used to treat infections in the clinic. As an invertebrate model, silkworm model is characterized by its convenience, low cost, no ethical issues. The presence of conserved immune response and similar pharmacokinetics compared to mammals make silkworm infection model suitable to examine the therapeutic effectiveness of antimicrobial agents...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28326070/antimicrobial-protection-of-marsupial-pouch-young
#17
REVIEW
Yuanyuan Cheng, Katherine Belov
Marsupials diverged from eutherian mammals about 148 million years ago and represent a unique lineage of mammals with distinctive morphological and reproductive characteristics. Marsupials have significantly shorter gestation periods than eutherians. Pregnancy typically ranges from 15 to 35 days, with young being born at a very early developmental stage and lacking differentiated lymphoid tissues and mature effector cells. Recent microbiome studies of the marsupial pouch revealed that marsupial young can face intense microbial challenges after birth, as the pouch contains a broad range of Gram-positive and Gram-negative bacteria...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28321210/production-of-ramoplanin-and-ramoplanin-analogs-by-actinomycetes
#18
Mercedes de la Cruz, Ignacio González, Craig A Parish, Russell Onishi, José R Tormo, Jesús Martín, Fernando Peláez, Debbie Zink, Noureddine El Aouad, Fernando Reyes, Olga Genilloud, Francisca Vicente
Ramoplanin is a glycolipodepsipeptide antibiotic obtained from fermentation of Actinoplanes sp. ATCC 33076 that exhibits activity against clinically important multi-drug-resistant, Gram-positive pathogens including vancomycin-resistant Enterococcus (VRE), methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-intermediate resistant Clostridium difficile. It disrupts bacterial cell wall through a unique mechanism of action by sequestering the peptidoglycan intermediate Lipid II and therefore does not show cross-resistance with other antibiotics...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28294685/star-anise-illicium-verum-hook-f-as-quorum-sensing-and-biofilm-formation-inhibitor-on-foodborne-bacteria-study-in-milk
#19
Md Ramim Tanver Rahman, Zaixiang Lou, Jun Zhang, Fuhao Yu, Yakindra Prasad Timilsena, Caili Zhang, Yi Zhang, Amr M Bakry
Bacteria use quorum sensing (QS) systems to communicate with each other and regulate microbial group behavior, such as the secretion of virulence factors, including biofilm formation. In order to explore safe, edible agents, the potential of star anise (SA) as an anti-QS and antibiofilm agent and its possible application in milk safety were investigated. Staphylococcus aureus , Salmonella Typhimurium, Pseudomonas aeruginosa , and biosensor strain Chromobacterium violaceum were selected as test strains for QS, biofilm, and exopolysaccharide assays...
March 15, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28273806/antimicrobial-dendrimeric-peptides-structure-activity-and-new-therapeutic-applications
#20
REVIEW
Mariano A Scorciapino, Ilaria Serra, Giorgia Manzo, Andrea C Rinaldi
Microbial resistance to conventional antibiotics is one of the most outstanding medical and scientific challenges of our times. Despite the recognised need for new anti-infective agents, however, very few new drugs have been brought to the market and to the clinic in the last three decades. This review highlights the properties of a new class of antibiotics, namely dendrimeric peptides. These intriguing novel compounds, generally made of multiple peptidic sequences linked to an inner branched core, display an array of antibacterial, antiviral and antifungal activities, usually coupled to low haemolytic activity...
March 3, 2017: International Journal of Molecular Sciences
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