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Dysplastic nevi

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https://www.readbyqxmd.com/read/27899968/prognostic-significance-of-the-expression-of-nuclear-eukaryotic-translation-initiation-factor-5a2-in-human-melanoma
#1
Shahram Khosravi, Magdalena Martinka, Youwen Zhou, Christopher J Ong
Eukaryotic translation initiation factor 5A2 (EIF5A2) expression is upregulated in various cancers. The present authors previously demonstrated that cytoplasmic EIF5A2 expression increases with melanoma progression and inversely correlates with patient survival. Other studies have suggested that nuclear EIF5A2 may also play a role in oncogenesis. The present study used immunohistochemistry and tissue microarray with a large number of melanocytic lesions (n=459) and demonstrated that nuclear EIF5A2 expression was significantly upregulated between common acquired nevi, dysplastic nevi and primary melanomas, and between primary melanomas and metastatic melanomas...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27890785/genomic-characterization-of-dysplastic-nevi-unveils-implications-for-diagnosis-of-melanoma
#2
Rachel D Melamed, Iraz T Aydin, Geena Susan Rajan, Robert Phelps, David N Silvers, Kevin J Emmett, Georg Brunner, Raul Rabadan, Julide Tok Celebi
A well-defined risk factor and precursor for cutaneous melanoma is the dysplastic nevus. These benign tumors represent clonal hyperproliferation of melanocytes that are in a senescent-like state, but with occasional malignant transformation events. To portray the mutational repertoire of dysplastic nevi in patients with the dysplastic nevus syndrome, and to determine the discriminatory profiles of melanocytic nevi (including dysplastic nevi) from melanoma, we sequenced exomes of melanocytic nevi including dysplastic nevi (n = 19), followed by a targeted gene panel (785 genes) characterization of melanocytic nevi (n = 46) and primary melanomas (n = 42)...
November 24, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27881943/number-and-size-of-acquired-melanocytic-nevi-and-affecting-risk-factors-in-cases-admitted-to-the-dermatology-clinic
#3
Ayşegül Yalçınkaya İyidal, Ülker Gül, Arzu Kılıç
INTRODUCTION: The size and number of acquired melanocytic nevi (AMN) and presence of dysplastic nevi are the leading risk factors that should be recognized in the development of malignant melanoma. AIM: To evaluate AMN and risk factors in the development of AMN in all age groups admitted to a dermatology outpatient clinic. MATERIAL AND METHODS: Four hundred and twelve patients who were admitted to the dermatology outpatient clinic for any dermatological symptom and who accepted to participate in the study were randomly included in the study...
October 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/27847790/synchronous-primary-anorectal-melanoma-and-sigmoid-adenocarcinoma
#4
Inju Cho, Kyung Jong Kim, Sung-Chul Lim
A primary anorectal malignant melanoma is a rare tumor. Moreover, cases involving a synchronous anorectal melanoma and colon adenocarcinoma are extremely rare. The authors report a case of a synchronous anorectal melanoma and sigmoid adenocarcinoma in an 84-year-old man. The regions of the anorectal melanoma showed melanocytic nevi in the adjacent mucosa of the anal canal and rectum. A dysplastic nevus was also identified in the anal mucosa. This case demonstrates that an anorectal melanoma can arise from pre-existing anorectal melanocytic lesions...
October 2016: Annals of Coloproctology
https://www.readbyqxmd.com/read/27843900/separate-primary-melanomas-of-the-bulbar-conjunctiva-and-eyelid-skin-clinical-implications-of-multiple-primary-melanomas
#5
Frances A Jacinto, George H Fisher, Edgar M Espana, Ilya M Leyngold, Curtis E Margo
PURPOSE: We report a patient with previous in situ melanoma of the forehead skin who was referred for treatment of a bulbar conjunctival melanoma and a separate superficially invasive melanoma of the eyelid skin, and we offer a review of the biological and clinical implications of patients who have multiple primary melanomas. METHODS: This article offers a clinicopathological correlation with a review of the relevant literature. RESULTS: An 80-year-old white man was referred for evaluation of a suspicious conjunctival tumor and a lower-eyelid lesion...
October 2016: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27783441/digital-imaging-biomarkers-feed-machine-learning-for-melanoma-screening
#6
Daniel Summer Gareau, Joel Correa da Rosa, Sarah Yagerman, John A Carucci, Nicholas Gulati, Ferran Hueto, Jennifer L DeFazio, Mayte Suárez-Farinas, Ashfaq Marghoob, James G Krueger
We developed an automated approach for generating quantitative image analysis metrics (imaging biomarkers) that are then analyzed with a set of thirteen machine-learning algorithms to generate an overall risk score that is called a Q-score. These methods were applied to a set of 120 "difficult" dermoscopy images of dysplastic nevi and melanomas that were subsequently excised/classified. This approach yielded 98% sensitivity and 36% specificity for melanoma detection, approaching sensitivity/specificity of expert lesion evaluation...
October 26, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27774100/recurrence-of-dysplastic-nevi-is-strongly-associated-with-extension-of-the-lesions-to-the-lateral-margins-and-into-the-deep-margins-through-the-hair-follicles-in-the-original-shave-removal-specimens
#7
Amin Maghari
Melanocytic nevi, including dysplastic or atypical nevi (DN), can recur or persist following shave removal procedures, and recurrence may resemble melanoma, both clinically and histologically (pseudomelanoma). Recurrence may originate from proliferation of the remaining neoplastic melanocytes following incomplete removal. The present study determines the rate and etiology of this event. A cross-sectional analysis of 110 excision specimens showing histological recurrence was performed, and these specimens were compared to the slides of the original shave specimens showing mildly atypical DN...
2016: Dermatology Research and Practice
https://www.readbyqxmd.com/read/27746632/expression-of-phosphatase-and-tensin-homologue-phospho-akt-and-p53-in-acral-benign-and-malignant-melanocytic-neoplasms-benign-nevi-dysplastic-nevi-and-acral-melanomas
#8
So Min Lyu, Ju Yeon Wu, Ji Yeon Byun, Hae Young Choi, Sang Hee Park, You Won Choi
BACKGROUND: The role of the phosphatidylinositol-3 kinase signaling pathway in the development of acral melanoma has recently gained evidence. Phosphatase and tensin homologue (PTEN), one of the key molecules in the pathway, acts as a tumor suppressor through either an Akt-dependent or Akt-independent pathway. Akt accelerates degradation of p53. OBJECTIVE: We assessed the expression of PTEN, phospho-Akt (p-Akt), and p53 by immunohistochemistry in benign acral nevi, acral dysplastic nevi, and acral melanomas in the radial growth phase and with a vertical growth component...
October 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27718503/immunohistochemical-analysis-of-t-type-calcium-channels-in-acquired-melanocytic-nevi-and-melanoma
#9
O Maiques, A Macià, S Moreno, C Barceló, M Santacana, A Vea, J Herreros, S Gatius, E Ortega, J Valls, B J Chen, D Llobet-Navas, X Matias-Guiu, C Cantí, R M Marti
BACKGROUND AND OBJECTIVES: Cutaneous malignant melanoma arises from transformed melanocytes de novo or from congenital or acquired melanocytic nevi. We have recently reported that T-type Ca(2+) channels (TTCs) are upregulated in human melanoma and play an important role on cell proliferation. The aim of this study was to describe for the first time in formalin-fixed-paraffin-embedded tissue the immunoexpression of TT-Cs in biopsies of normal skin, acquired melanocytic nevi and melanoma, in order to evaluate their role in melanomagenesis and/or tumor progression, their utility as prognostic markers and their possible use in targeted therapies...
October 8, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27692732/variation-among-pathologists-treatment-suggestions-for-melanocytic-lesions-a-survey-of-pathologists
#10
Kachiu C Lee, Sue Peacock, Martin A Weinstock, Ge Alice Zhao, Stevan R Knezevich, David E Elder, Raymond L Barnhill, Michael W Piepkorn, Lisa M Reisch, Patricia A Carney, Tracy Onega, Jason P Lott, Joann G Elmore
BACKGROUND: The extent of variability in treatment suggestions for melanocytic lesions made by pathologists is unknown. OBJECTIVE: We investigated how often pathologists rendered suggestions, reasons for providing suggestions, and concordance with national guidelines. METHODS: We conducted a cross-sectional survey of pathologists. Data included physician characteristics, experience, and treatment recommendation practices. RESULTS: Of 301 pathologists, 207 (69%) from 10 states (California, Connecticut, Hawaii, Iowa, Kentucky, Louisiana, New Jersey, New Mexico, Utah, and Washington) enrolled...
September 28, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27672411/enhancement-of-international-dermatologists-pigmented-skin-lesion-biopsy-decisions-following-dermoscopy-with-subsequent-integration-of-multispectral-digital-skin-lesion-analysis
#11
Richard R Winkelmann, Aaron S Farberg, Natalie Tucker, Richard White, Darrell S Rigel
BACKGROUND: Early detection and subsequent management of melanoma are critical for patient survival. New technologies have been developed to augment clinician analysis of suspicious pigmented skin lesions. OBJECTIVE: To determine how information provided by a multispectral digital skin lesion analysis device affects the biopsy decisions of international dermatologists following clinical and dermoscopic pigmented skin lesion evaluation. METHODS: Participants at a dermoscopy conference in Vienna, Austria, were shown 12 clinical and dermoscopic images of pigmented skin lesions (2 melanomas in situ, 3 invasive melanomas, and 7 low-grade dysplastic nevi) previously analyzed by multispectral digital skin lesion analysis...
July 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27664709/new-insights-into-the-molecular-distinction-of-dysplastic-nevi-and-common-melanocytic-nevi-highlighting-the-keratinocyte-melanocyte-relationship
#12
Philip Eliades, Hensin Tsao
Mitsui et al. approach the problem of differentiating dysplastic nevi from common melanocytic nevi through a molecular lens. Whereas most of the literature on this topic shines the spotlight toward melanocytes, the focus of this paper is shifted to the tumor microenvironment. Using microarrays, reverse transcriptase-PCR, and immunohistochemistry, their results emphasize the role of keratinocyte dysplasia within dysplastic nevi.
October 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27617734/agminated-melanocytic-nevus-status-post-dabrafenib-therapy-for-metastatic-melanoma
#13
Alfredo Agulló, Brian Hinds, Raquel Santesteban, Josune Mitxelena Mitxelena, Ignacio Yanguas
Agminated melanocytic nevus is an uncommon type of mole, characterized by a local group of macular or papular pigmented lesions, well demarcated, without a common pigmented background. This pattern has also been associated with Spitz nevi, dysplastic melanocytic nevi, and non-melanocytic lesions.We describe the onset of an acquired agminated melanocytic nevus after dabrafenib treatment. Our case highlights paradoxical MAPK activation in the setting of single-agent BRAF blockade and underscores the importance of characterizing the diverse side effects of selective BRAF inhibitors...
2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27551173/dermatological-findings-in-turkish-paediatric-haematology-oncology-patients
#14
Umit Uksal, Pinar Ozturk, Emine Colgecen, Nazan Taslidere, Turkan Patiroglu, Mehmet Akif Ozdemir, Yasemin Altuner Torun, Murat Borlu
OBJECTIVE: Diagnoses of skin, mucosae, hair and nail manifestations in malignant diseases are often challenging because of life-threatening drug reactions, opportunistic infections or skin involvement of primary processes. Description of morphology, configuration and distribution of lesions is important in order to differentiate the self-healing eruptions from serious side effects of chemotherapy. There are case reports from Turkey including dermatological manifestations of malignancies and case series in adult patients but there are no published large group studies assessing all manifestations in children...
June 2016: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/27542070/reexamining-the-threshold-for-reexcision-of-histologically-transected-dysplastic-nevi
#15
Nathaniel H Fleming, Barbara M Egbert, Jinah Kim, Susan M Swetter
Importance: Controversy persists regarding the appropriate management of incompletely excised, biopsy-proven, mild and moderate dysplastic nevi (DN). Objective: To determine long-term risk of associated melanoma in biopsied mild or moderate DN with positive histologic margins that were clinically observed vs reexcised with negative margins. Design, Setting, and Participants: Retrospective cohort study of mixed referral and community patients from an academic pigmented lesion clinic and dermatology clinics of the affiliated Veteran Affairs medical center with biopsy-confirmed DN with positive histologic margins diagnosed from May 15, 1991, to July 8, 2015, and followed up through May 30, 2016...
August 17, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27461337/automated-quantification-of-ki67-mart1-stains-may-prevent-false-negative-melanoma-diagnoses
#16
Anne Wandler, Eva Spaun, Torben Steiniche, Patricia S Nielsen
BACKGROUND: Inability to distinguish melanomas from benign nevi is the most frequent reason for malpractice lawsuits in surgical pathology. Reliable diagnostic tools to support hematoxylin and eosin (H&E) stains and induce diagnostic vigilance are thus highly needed. Because high diagnostic performance recently was showed using automated image analysis, the immunohistochemical proliferation marker Ki67 seems a potential candidate. This study aimed to investigate if this previously presented automated algorithm could have prevented 10 false-negative melanoma diagnoses...
July 27, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27436823/dysplastic-or-atypical-nevi-showing-moderate-or-severe-atypia-with-clear-margins-on-the-shave-removal-specimens-are-most-likely-completely-excised
#17
Amin Maghari
BACKGROUND: Dysplastic nevi (DN) are graded by their degree of atypia into 3 categories of mild, moderate, and severe. In many practices, DN with moderate or severe atypia are generally excised regardless of the status of the shave specimen margins. OBJECTIVE: With a new approach toward the margins on the shave removal specimens (SRS), the goal herein is to assess whether the shave removal procedure can sufficiently remove DN with moderate or severe atypia. METHODS: A total of 426 SRS diagnosed with DN showing moderate or severe atypia between January and December 2015 along with their post-shave excision specimens were reviewed...
July 19, 2016: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27377700/discrimination-of-dysplastic-nevi-from-common-melanocytic-nevi-by-cellular-and%C3%A2-molecular-criteria
#18
Hiroshi Mitsui, Felix Kiecker, Avner Shemer, Maria Vittoria Cannizzaro, Claire Q F Wang, Nicholas Gulati, Hanako Ohmatsu, Kejal R Shah, Patricia Gilleaudeau, Mary Sullivan-Whalen, Inna Cueto, Neil Scott McNutt, Mayte Suárez-Fariñas, James G Krueger
Dysplastic nevi (DNs), also known as Clark's nevi or atypical moles, are distinguished from common melanocytic nevi by variegation in pigmentation and clinical appearance, as well as differences in tissue patterning. However, cellular and molecular differences between DNs and common melanocytic nevi are not completely understood. Using cDNA microarray, quantitative RT-PCR, and immunohistochemistry, we molecularly characterized DNs and analyzed the difference between DNs and common melanocytic nevi. A total of 111 probesets (91 annotated genes, fold change > 2...
October 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27354886/correlation-between-the-evaluation-of-pigmented-lesions-by-a-multi-spectral-digital-skin-lesion-analysis-device-and-the-clinical-and-histological-features-of-melanoma
#19
Richard R Winkelmann, Darrell S Rigel, Laura Ferris, Arthur Sober, Natalie Tucker, Clay J Cockerell
OBJECTIVE: To correlate Multi-spectral Digital Skin Lesion Analysis classifier scores with histopathological severity of pigmented lesions and clinical features of melanoma. DESIGN: Classifier scores were computed for 1,632 skin lesions. Dermatologists evaluated the same lesions for Asymmetry, Border Irregularity, Color variegation, Diameter >6mm, Evolution, Patient's Concern, Regression, and/or "Ugly Duckling" sign. Classifier scores were correlated to the number of clinical risk features and for six histopathological severity levels of pigmented lesions...
March 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27328525/serum-prolactin-in-melanoma-patients-with-interferon-alpha2b-treatment
#20
Corina-Daniela Ene, Ilinca Nicolae
UNLABELLED: The authors' interest was focused on prolactin status in patients with melanocytic lesions and on changes induced by interferon treatment in melanoma patients. MATERIAL AND METHOD: The study lasted 5 years and included 128 melanoma patients, 48 dysplastic nevi patients and 48 healthy volunteers. Sixty melanoma cases were selected after surgical removal of tumor and divided into 2 groups: 30 patients with 10 MUmp(-1) interferon alpha2b treatment, three times a week, one year and 30 patients without interferon treatment...
July 2015: Roumanian Archives of Microbiology and Immunology
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