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https://www.readbyqxmd.com/read/29785330/dermoscopy-of-a-spark-s-nevus
#1
Giovanni Biondo, Matteo Gnone, Simona Sola, Carlotta Pastorino, Cesare Massone
Spark's nevus is a particular type of melanocytic nevus that on histology shows features of both Spitz's and Clark's nevus. Clinically, it is an asymmetric, irregular, multicolored, pigmented lesion that is not clearly distinguishable from melanoma or dysplastic (Clark's) nevus. Dermoscopic features have not been described yet, and one could speculate that they are similar to those of Clark's nevi because the histopathologic architecture of Spark's nevus is similar to that of a Clark's nevus, resembling Spitz's nevi in the epithelioid morphology of melanocytes...
April 2018: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29752800/raman-biophysical-markers-in-skin-cancer-diagnosis
#2
Xu Feng, Austin J Moy, Hieu T M Nguyen, Yao Zhang, Jason Zhang, Matthew C Fox, Katherine R Sebastian, Jason S Reichenberg, Mia K Markey, James W Tunnell
Raman spectroscopy (RS) has demonstrated great potential for in vivo cancer screening; however, the biophysical changes that occur for specific diagnoses remain unclear. We recently developed an inverse biophysical skin cancer model to address this issue. Here, we presented the first demonstration of in vivo melanoma and nonmelanoma skin cancer (NMSC) detection based on this model. We fit the model to our previous clinical dataset and extracted the concentration of eight Raman active components in 100 lesions in 65 patients diagnosed with malignant melanoma (MM), dysplastic nevi (DN), basal cell carcinoma, squamous cell carcinoma, and actinic keratosis...
May 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29675324/differentiation-of-seborrheic-keratosis-from-basal-cell-carcinoma-nevi-and-melanoma-by-rgb-autofluorescence-imaging
#3
Alexey Lihachev, Ilze Lihacova, Emilija V Plorina, Marta Lange, Alexander Derjabo, Janis Spigulis
A clinical trial on the autofluorescence imaging of skin lesions comprising 16 dermatologically confirmed pigmented nevi, 15 seborrheic keratosis, 2 dysplastic nevi, histologically confirmed 17 basal cell carcinomas and 1 melanoma was performed. The autofluorescence spatial properties of the skin lesions were acquired by smartphone RGB camera under 405 nm LED excitation. The diagnostic criterion is based on the calculation of the mean autofluorescence intensity of the examined lesion in the spectral range of 515 nm-700 nm...
April 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29570779/surgical-re-excision-versus-observation-for-histologically-dysplastic-nevi-a-systematic-review-of-associated-clinical-outcomes
#4
REVIEW
K T Vuong, J Walker, H Powell, N E Thomas, D E Jonas, A S Adamson
The management of histologically dysplastic nevi (HDN) with re-excision versus observation remains controversial due to lack of evidence about associated melanoma outcomes. This systematic review of all published data assessed the development of biopsy site primary cutaneous melanoma among biopsy-proven HDN managed with either re-excision or observation. A total of 5,293 records were screened, 18 articles were assessed in full-text, and 12 studies met inclusion criteria. No controlled trials were identified...
March 23, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29528027/a-multicenter-survey-how-do-transplant-dermatologists-monitor-organ-transplant-recipients-with-nevi
#5
Deren Özcan, Deniz Seçkin, Mehmet Haberal
OBJECTIVES: The incidence and mortality of melanoma are increased in organ transplant recipients. Multiple acquired common and dysplastic nevi are risk factors for melanoma. A new or changing nevus may suggest melanoma. Strategies used by transplant dermatologists to monitor nevi are unknown. Herein, we aimed to assess the methods used by transplant dermatologists for monitoring multiple acquired common nevi, dysplastic nevi, and new or changing nevi. MATERIALS AND METHODS: A questionnaire was e-mailed to 63 members of the Skin Care in Organ Transplant Patients, Europe...
March 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29507566/oncogenic-braf-mutations-and-p16-expression-in-melanocytic-nevi-and-melanoma-in-the-polish-population
#6
Małgorzata Mackiewicz-Wysocka, Patrycja Czerwińska, Violetta Filas, Elżbieta Bogajewska, Agata Kubicka, Anna Przybyła, Ewelina Dondajewska, Tomasz Kolenda, Andrzej Marszałek, Andrzej Mackiewicz
Introduction: Twenty-five - fifty percent of skin melanomas arise from nevi. Melanocyte proliferation is activated by BRAF V600E , then is arrested, but single nevi transform to melanomas. p16 controls arrest, and p16 loss may promote transformation. Aim: To analyze BRAF V600E , p16 expression and melanocyte proliferation in dermal, compound and dysplastic nevi, cells of primary and metastatic melanoma in the Polish population. Material and methods: One hundred and thirty-two nevi (dermal, compound, dysplastic) and 41 melanomas ( in situ , primary, metastatic) were studied...
October 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29484015/small-dysplastic-congenital-melanocytic-nevi-in-childhood-as-possible-melanoma-imitators
#7
Georgi Tchernev, Anastasiya Atanasova Chokoeva, Ivan Terziev, Yavor Grigorov, Torello Lotti, Uwe Wollina, José Carlos Cardoso, Irina Yungareva, Ilia Lozev, Georgi Konstantinov Maximov
Small pigmented lesions in children can represent a significant diagnostic challenge. If the diagnostic features and therapeutic approach are relatively well established in large and giant nevi, there is still much controversy regarding small and intermediate-sized congenital pigmented lesions that can lead to significant diagnostic challenges, both clinically and dermoscopically, and consequently to difficulty in defining the optimal approach in such cases. Although dermoscopy can be useful in the diagnosis of pigmented lesions, the diversity of clinical and dermoscopic features of pigmented nevi in children usually hinder the differentiation between them and melanoma...
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29469735/quantitative-abcd-parameters-measured-by-a-multispectral-digital-skin-lesion-analysis-device-for-evaluation-of-suspicious-pigmented-skin-lesions-strongly-correlate-with-clinical-abcd-observations
#8
Alex M Glazer, Aaron S Farberg, Richard R Winkelmann, Natalie Tucker, Darrell S Rigel
Background/Study Aim: A multispectral digital skin lesion analysis (MSDSLA) device has proven to be sensitive and specific for malignant melanoma (MM) detection by dermatologists and may have other useful applications. This study aimed to develop and test objective quantitative Asymmetry, Border irregularity, Color, and Diameter (qABCD) parameters for MSDSLA and correlate them with the presence of clinical ABCD features to aid the decision to biopsy a suspicious pigmented skin lesions (PSLs). METHODS: 1632 benign and malignant [175 MM/High Grade Dysplastic Nevi (HGDN)] were evaluated for their qABCD parameters...
August 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29249120/the-variegated-histopathological-features-of-atypical-lentiginous-melanocytic-nevi-almns-a-single-institution-experience
#9
Alessia Barisani, Salvatore D Infusino, Cosimo Misciali, Beatrice Passarini, Nunzio C Salfi, Elisa Varotti, Annalisa Patrizi
BACKGROUND: Atypical lentiginous melanocytic nevi (ALMNs) are atypical pigmented lesions with histopathological features similar to those of dysplastic nevi, with a lentiginous pattern. Variable histopathological features of ALMNs were observed in our practice. METHODS: We described the histopathological features of ALMNs diagnosed in the period 2009- 2015. Our cases were divided into 2 groups: Group 1: ALMNs showing the same histopathological features as previously described in the literature; Group 2: ALMNs with different features...
December 15, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29138058/the-diagnostic-value-and-histologic-correlate-of-distinct-patterns-of-shiny-white-streaks-for-the-diagnosis-of-melanoma-a-retrospective-case-control-study
#10
Anna Eliza Verzi, Victor L Quan, Kara E Walton, Mary C Martini, Ashfaq A Marghoob, Erin M Garfield, Betty Y Kong, Maria Cristina Isales, Timothy VandenBoom, Bin Zhang, Dennis P West, Pedram Gerami
BACKGROUND: Shiny white streaks (SWSs) are best visualized with polarized dermoscopy and correlate with dermal fibroplasia histopathologically. SWSs have been described at higher frequencies in melanomas than in benign nevi. OBJECTIVE: We assessed the diagnostic value of different patterns of SWSs and their histologic correlate in melanocytic lesions. METHODS: Polarized dermoscopic images of 1507 histopathologically diagnosed melanocytic neoplasms were analyzed for presence and pattern of SWSs...
November 11, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29094145/population-based-analysis-of-histologically-confirmed-melanocytic-proliferations-using-natural-language-processing
#11
Jason P Lott, Denise M Boudreau, Ray L Barnhill, Martin A Weinstock, Eleanor Knopp, Michael W Piepkorn, David E Elder, Steven R Knezevich, Andrew Baer, Anna N A Tosteson, Joann G Elmore
Importance: Population-based information on the distribution of histologic diagnoses associated with skin biopsies is unknown. Electronic medical records (EMRs) enable automated extraction of pathology report data to improve our epidemiologic understanding of skin biopsy outcomes, specifically those of melanocytic origin. Objective: To determine population-based frequencies and distribution of histologically confirmed melanocytic lesions. Design, Setting, and Participants: A natural language processing (NLP)-based analysis of EMR pathology reports of adult patients who underwent skin biopsies at a large integrated health care delivery system in the US Pacific Northwest from January 1, 2007, through December 31, 2012...
January 1, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/28982585/a-prospective-study-evaluating-the-utility-of-a-2-mm-biopsy-margin-for-complete-removal-of-histologically-atypical-dysplastic-nevi
#12
Vitaly Terushkin, Elise Ng, Jennifer A Stein, Susan Katz, David E Cohen, Shane Meehan, David Polsky
BACKGROUND: Complete removal of individual dysplastic nevi (DN) is often accomplished by a second surgical procedure after the initial biopsy. The choice to perform the second procedure is strongly influenced by histopathologic margin status of the initial biopsy specimen. OBJECTIVE: To evaluate the clinical and histopathologic outcomes of in toto biopsy of DN using a predetermined margin of normal skin. METHODS: We conducted a prospective study of a saucerization method using a defined 2-mm margin in patients undergoing biopsy of a pigmented skin lesion...
December 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28976087/noninvasive-diagnosis-in-dermatology
#13
Julia Welzel, Sandra Schuh
In addition to dermoscopy, there are other imaging and biophysical methods for the noninvasive diagnosis of skin lesions. Confocal laser microscopy allows for high-resolution imaging of the epidermis and upper dermis. It is particularly suitable in the differential diagnosis of melanocytic lesions. Optical coherence tomography (OCT) has a lower resolution compared to confocal laser microscopy but a greater depth of penetration. It is primarily used for imaging epithelial skin cancer, especially in the context of monitoring the effectiveness of nonsurgical therapies...
October 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28903138/improvement-of-genetic-testing-for-cutaneous-melanoma-in-countries-with-low-to-moderate-incidence-the-rule-of-2-vs-the-rule-of-3
#14
Juliette Delaunay, Ludovic Martin, Brigitte Bressac-de Paillerets, Gerard Duru, Olivier Ingster, Luc Thomas
Importance: Genetic testing for melanoma-prone mutation in France, a country with low to moderate incidence of melanoma, is proposed in cases with 2 invasive cutaneous melanomas and/or related cancers in the same patient, or in first- or second-degree relatives (rule of 2). In preclinical studies, these rules led to disclosure of mutation(s) in more than 10% of these families, the threshold widely accepted to justify genetic testing for cancers. Objective: To reconsider these criteria in a general population testing of patients...
November 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28864306/a-meta-analysis-of-nevus-associated-melanoma-prevalence-and-practical-implications
#15
REVIEW
Riccardo Pampena, Athanassios Kyrgidis, Aimilios Lallas, Elvira Moscarella, Giuseppe Argenziano, Caterina Longo
The reported prevalence of nevus-associated melanoma varies substantially. We performed a systematic review and meta-analysis to determine the incidence and prevalence of this disease; we also performed subanalyses considering age, tumor thickness, and nevus-type classification. In 38 observational cohort and case-control studies, 29.1% of melanomas likely arose from a preexisting nevus and 70.9% de novo. Any given melanoma was 64% less likely to be nevus-associated than de novo (risk ratio 0.36, 95% confidence interval [CI] 0...
November 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28843749/evaluation-of-expression-of-genes-cadm1-twist1-and-cdh1-by-immunohistochemestry-in-melanocytic-lesions
#16
Karina Munhoz de Paula Alves Coelho, Jaqueline Stall, Hercílio Fronza Júnior, Rodrigo Blasius, Paulo Henrique Condeixa de França
AIM: Malignant melanoma is an aggressive disease and its incidence is increasing worldwide. Genetic predisposition and exposure to environmental factors, especially sunlight, are risk factors. Histopathologic distinction between nevi and melanomas can be difficult. It is anticipated that the evaluation of the immunohistochemical expression of some genes could contribute to the differential diagnosis of questionable histologically lesions. The objective of this study was to investigate wether the evaluation of the immunohistochemical expression of genes CADM1, TWIST1 and CDH1 (E-cadherin), that take part in mechanisms of cell adhesion and epithelial-mesenchymal transition, contributes to the differential diagnosis of melanocytic lesions difficult to diagnose...
August 1, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28748967/melanocytic-nevi-and-non-neoplastic-hyperpigmentations
#17
C Clemente
This is the first of three chapters that will be progressively published on Pathologica as updating activity of the Italian Study Group of Dermatopathology (GISD), Italian Society of Pathology and Cytology (SIAPeC IAP). The first chapter concerns non-neoplastic hyperpigmented skin lesions and nevi, the second will address the topics of dysplastic nevus, borderline and low malignant potential melanocytic proliferations and the third melanoma in its variants and differential diagnoses with a supplement on the immunohistochemistry and molecular support to diagnostic and prognostic definition of nevi and melanomas...
June 2017: Pathologica
https://www.readbyqxmd.com/read/28659278/pathologists-diagnosis-of-invasive-melanoma-and-melanocytic-proliferations-observer-accuracy-and-reproducibility-study
#18
MULTICENTER STUDY
Joann G Elmore, Raymond L Barnhill, David E Elder, Gary M Longton, Margaret S Pepe, Lisa M Reisch, Patricia A Carney, Linda J Titus, Heidi D Nelson, Tracy Onega, Anna N A Tosteson, Martin A Weinstock, Stevan R Knezevich, Michael W Piepkorn
Objective To quantify the accuracy and reproducibility of pathologists' diagnoses of melanocytic skin lesions.Design Observer accuracy and reproducibility study.Setting 10 US states.Participants Skin biopsy cases (n=240), grouped into sets of 36 or 48. Pathologists from 10 US states were randomized to independently interpret the same set on two occasions (phases 1 and 2), at least eight months apart.Main outcome measures Pathologists' interpretations were condensed into five classes: I (eg, nevus or mild atypia); II (eg, moderate atypia); III (eg, severe atypia or melanoma in situ); IV (eg, pathologic stage T1a (pT1a) early invasive melanoma); and V (eg, ≥pT1b invasive melanoma)...
June 28, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28562437/use-of-skin-biopsies-among-dermatologists
#19
David A Weinstein, Sasank Konda, Brett M Coldiron
BACKGROUND: Skin biopsies are essential to establish a diagnosis in many skin diseases. Utilization has been increasing rapidly and represents a significant health care cost. There are no benchmarks or baselines to guide the practice of skin biopsies. OBJECTIVE: To create a reference data set of biopsy behavior among dermatologists. METHODS: Five hundred eighty-eight dermatologists belonging to the American Dermatological Association (ADA) were surveyed...
November 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28480118/predictive-nuclear-chromatin-characteristics-of-melanoma-and-dysplastic-nevi
#20
Matthew G Hanna, Chi Liu, Gustavo K Rohde, Rajendra Singh
BACKGROUND: The diagnosis of malignant melanoma (MM) is among the diagnostic challenges pathologists encounter on a routine basis. Melanoma may arise in patients with preexisting dysplastic nevi (DN) and it is still the cause of 1.7% of all cancer-related deaths. Melanomas often have overlapping histological features with DN, especially those with severe dysplasia. Nucleotyping for identifying nuclear textural features can analyze nuclear DNA structure and organization. The aim of this study is to differentiate MM and DN using these methodologies...
2017: Journal of Pathology Informatics
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