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S A Matveeva
Lipid-protein relationships were studied in 155 men and women (mean age 48/9 +/ -0.6 years) with CHD (stable angina of effort) and MS. The frequency of concomitant arterial hypertension in men/women was 100%, aortic atherosclerosis 49.7/24.5%, athersclerosis of lower leg arteries 14.8/0%, chronic obstructive pulmonary disease 27.7/5.2%, locomotor disorders 25.8/14.8%, hepato-biliary diseases 24.5/17.4%, gastro-duodenal disorders 16.8/3.2%, hepatic problems 10.5/26.7%. Heterogeneity of lipid-protein homeostasis was documented...
2012: Klinicheskaia Meditsina
Slavko Simeunović, Srećko Nedeljković, Zeljka Milincić, Milija Vukotić, Ivana Novaković, Nada Majkić-Singh, Dejan Nikolić, Dijana Risimić, Dejan Simeunović, Ivana Petronić, Vladimir Radlović
INTRODUCTION: Athersclerosis is a multifactorial disease that begins in childhood. There are few reports regarding influence of risk factors on the atherosclerotic processes in early period of life and adolescence. OBJECTIVE: The aim of this study was to present and analyze risk factor trends in school children over a 10-year period that were included and followed-up by the Yugoslav Study of Atherosclerosis Precursors in School Children (YUSAD Study). METHODS: There were three examinations of selected population from 13 centres...
July 2011: Srpski Arhiv za Celokupno Lekarstvo
K Gaus, E A Hall
Management of atherosclerosis is a high priority target. If this is to be achieved, the early detection of risk and risk factors are paramount and integrated with this is a need for the detection of the oxidation state of a patient's low density lipoprotein (LDL). Presently no readily usable technique exists for their rapid determination and in order to develop such a technique a monitoring system must be devised which distinguishes a parameter which changes on oxidation and distinguishes critical and noncritical oxidation products...
July 1, 1999: Analytical Chemistry
Robin L Brey
Neuropsychiatric lupus (NPSLE) manifestations are common in adults and children and are associated with an increase in both morbidity and mortality. Cognitive dysfunction, when standardly assessed using sensitive neurocognitive instruments, is the most common NPSLE manifestation. The pathogenic etiologies of NPSLE manifestations are likely to be multifactorial and may involve autoantibody production, microangiopathy, intrathecal production of proinflammatory cytokines and athersclerosis. It is becoming more clear that the integrity of the blood-brain-barrier is very important in SLE-related neuropathology...
2007: Bulletin of the NYU Hospital for Joint Diseases
D Martijn O Pruissen, Susan A M Gerritsen, Talitha J Prinsen, Joke M Dijk, L Jaap Kappelle, Ale Algra
BACKGROUND AND PURPOSE: The role of athersclerosis in the difference between the pathogenesis of large-vessel disease (LVD) and small-vessel disease (SVD) is a matter of debate. Common carotid artery intima-media thickness (CCA IMT) is a marker of atherosclerosis. Our aim was to compare CCA IMT between SVD and LVD patients. METHODS: Two independent observers classified ischemic stroke or transient ischemic attack as caused by SVD or LVD, primarily based on imaging and in addition on clinical features...
April 2007: Stroke; a Journal of Cerebral Circulation
Joanna Tołwińska, Barbara Głowińska, Mirosława Urban, Bozena Pieciukiewicz
UNLABELLED: According to very well documented onset of atherosclerosis in early childhood, scientists are looking for good diagnostic methods for evaluating first changes in arterial blood vessels noninvasively. We want to know more about pathogenetic mechanisms and about changes in vessels especially in the group of young people with risk factors of premature atherosclerosis. The role of endothelial dysfunction in the very early phase of this process is known well so far. High resolution echocardiography seems to be a good method which allows to examine arteries in children and adolescents...
2005: Przegla̧d Lekarski
O G Opadijo, A A Akande, A K Jimoh
This study is to determine the prevalence of coronary heart disease risk factors in Nigerians with systemic hypertension. Serum lipid profile and fasting blood glucose were determined in one hundred and thirty six newly diagnosed hypertensives selected from the Medical Outpatient Department. Basic demographic data as well as medico-social history was extracted from the records. Coronary heart disease risk was calculated from the ratios of high-density lipoprotein cholesterol to total cholesterol. High risk were defined as CHD ratio <0...
June 2004: African Journal of Medicine and Medical Sciences
Rhena Delport, Arnulf W Lingenhel, Johan B Ubbink, Hans G Kraft
BACKGROUND: Homocyst(e)ine is reported to increase the binding of lipoprotein(a) [Lp(a)] to fibrin, which may increase the thrombogenic effects of Lp(a) in vivo. The aim of this study was to investigate whether there is a relationship between homocyst(e)ine and Lp(a) levels and vascular disease risk, and if the relationship depends on the apo(a) isoforms. METHODS: A case-control study was performed in 91 Caucasian male subjects with vascular disease due to athersclerosis, and in 100 healthy age- and sex-matched control subjects...
September 2004: Cardiovascular Journal of South Africa
Ziyad Al Aly, John C Edwards
Cardiovascular disease is the leading cause of death in patients with end-stage renal disease. Although the prevalence of traditional atherosclerotic risk factors is increased in patients with chronic kidney disease, these traditional risk factors alone do not seem to account for the increased cardiovascular mortality. It has been proposed that additional risk factors may play a role in vascular injury. Among nontraditional risk factors, chronic inflammation, oxidative stress, and vascular calcification have been implicated in the accelerated athersclerosis of chronic kidney disease...
July 2004: Advances in Chronic Kidney Disease
Jonathan Abrams
The recognition that inflammation is closely related to atherothrombosis, diabetes, and the metabolic syndrome, represents an enormously important advance in medical science. The prevention community initially took a very cautious approach to recommending CRP measurements, in part because of the variable quality of assays; the advent of high sensitivity CRP measurements and the remarkable research output from Ridker's lab and many others, has demonstrated that this inflammatory marker can provide useful prognostic information, and has contributed a great deal to our understanding of pathobiology...
August 2003: Cardiology Clinics
No abstract text is available yet for this article.
February 1964: Zdravookhranenie Belorussii
Eiji Kubota, Rachel G Dean, Leanne C Balding, Louise M Burrell
The natriuretic peptide and renin-angiotensin systems are physiological counterparts with opposite roles in the regulation of electrolyte balance and blood pressure. In both systems, membrane-bound, zinc-dependent peptidases play an important role in the inactivation or activation of the system. Angiotensin-converting enzyme (ACE) converts angiotensin I into angiotensin II, and neutral endopeptidase (NEP) degrades the natriuretic peptides. Simultaneous inhibition NEP and ACE by a single molecule (a vasopeptidase inhibitor) is a new therapeutic approach in hypertension...
2002: Essays in Biochemistry
Arthur W Zieske, Gray T Malcom, Jack P Strong
The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study was organized to document the natural history of athersclerosis and to determine the relation of cardiovascular risk factors to atherosclerosis in young subjects. Pathology laboratories in 15 centers collected coronary arteries, aortas, and other tissues from over 3,000 subjects age 15 to 34 who died of external causes between 1987 and 1994. The extent, prevalence, and topography of arterial lesions were evaluated and risk factors were analyzed in a central laboratory...
March 2002: Pediatric Pathology & Molecular Medicine
H A Schenkein, C R Berry, D Purkall, J A Burmeister, C N Brooks, J G Tew
Antibodies reactive with phosphorylcholine (PC) are ubiquitous in human sera, but the antigens stimulating their production and their function are not clear. Previous studies have shown that a significant proportion of dental plaque bacteria contain PC as determined by reactivity with PC-specific mouse myeloma proteins and monoclonal antibodies. Additionally, serum antibody concentrations of immunoglobulin (IgG) G anti-PC are higher in sera of individuals who have experienced periodontal attachment loss than those who are periodontally healthy...
November 2001: Infection and Immunity
S D Katugampola, Z Pallikaros, A P Davenport
1. Ghrelin is the recently identified endogenous ligand for the cloned growth hormone secretagogue receptor (GHS-R). We have characterized for the first time the binding of human [125I-His(9)]-ghrelin to normal human and rat tissue and demonstrated expression of this 'orphan' receptor that has previously been predicted to exist from mRNA. Furthermore, we have discovered that [125I-His(9)]-ghrelin density is significantly increased in atherosclerosis. 2. [125I-His(9)]-Ghrelin bound to non-diseased human heart (left ventricle) with an association rate constant (k(obs)) of 0...
September 2001: British Journal of Pharmacology
J P Cooke, R K Oka
In patients who have elevated levels of plasma ADMA, a relative deficiency of L-arginine has been found to contribute to the pathophysiology of athersclerosis, causing vasoconstriction, and accelerating atherogenesis. This finding--that there is a relative deficiency of L-arginine in atherosclerotic disease--is a breakthrough that will open new avenues of therapy.
May 2001: Current Atherosclerosis Reports
S P Zhao, D Y Xu
Lipoprotein(a) [Lp(a)] has been demonstrated to be an independent risk factor for coronary heart disease. However, the precise mechanism by which it contributes to the development of atherosclerosis remains unclear. P-selectin is one of the major adhesion molecules to mediate the interaction between monocytes, platelets and endothelial cells. Increased expression of P-selectin has been frequently found in atherosclerotic lesions. The present study assessed the effects of native and oxidized LDL (n-LDL and ox-LDL) and Lp(a) (n-Lp(a) and ox-Lp(a)) on the expression of P-selectin in cultured human umbilical vein endothelial cells (HUVECs)...
December 15, 2000: Thrombosis Research
S C Tyagi, S Kumar, L Katwa
Heparin has been shown to stimulate angiogenesis in the border zones surrounding infarcted myocardium. Matrix metalloproteinases (MMP), which are involved in extracellular matrix (ECM) organization, have also been shown to be activated. Cholesterol is required for receptor signaling in the plasma membrane, but a role of MMPs for cholesterol in ECM remodeling has not yet been shown. To examine whether heparin and cholesterol induce MMP and tissue inhibitor of metalloproteinase (TIMP) in human heart fibroblast (HHF) cells, confluent HHF cells were treated with cholesterol (100 microM) or heparin (20 microM)...
January 1997: Journal of Molecular and Cellular Cardiology
F Crea, A Gaspardone, F Tomai, C Shoulders, A De Fazio, F Versaci, M Iamele, C Roncaglioni, M Gioffré, A Maseri
OBJECTIVES: The aim of this study was to compare risk factors for coronary atherosclerosis in children with a family history of unheralded myocardial infarction or uncomplicated stable angina. BACKGROUND: In patients with unheralded myocardial infarction, coronary atherosclerosis might have a greater tendency to cause acute coronary occlusion than in patients with uncomplicated stable angina, suggesting the possibility of different risk factors in these two groups of patients...
May 1994: Journal of the American College of Cardiology
A C Asmal, W P Leary, F Thandroyen
The fact that a significant proportion of diabetics die of heart disease has led to the belief that the excess mortality is due to coronary athersclerosis, yet many risk factors for the latter are common to diabetics and non-diabetics. In fact, heart disease in diabetes is not synonymous with coronary heart disease. There is evidence that heart disease in diabetes includes a variable combination of coronary atheroma, cardiomyopathy, micro-angiopathy and autonomioc neuropathy.
May 10, 1980: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
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