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https://www.readbyqxmd.com/read/29915257/association-of-gyra-and-rrs-gene-mutations-detected-by-mtbdrsl-v1-on-mycobacterium-tuberculosis-strains-of-diverse-genetic-background-from-india
#1
Syed Beenish Rufai, Jitendra Singh, Parveen Kumar, Purva Mathur, Sarman Singh
There is limited data on the use of Genotype MTBDRslVersion 1 (MTBDRsl V1) as an initial rapid screening test to rule out XDR-TB and most importantly its performance in various genotypes of Mycobacterium tuberculosis is scarcely studied. A total of 359 MDR-TB isolates were tested for gene mutations representing second line drug resistance, using the MTBDRsl_V.1 and the results were compared with phenotypic method (Bactec MGIT-960 system) for second-line drug (SLD) susceptibility testing. Genetic lineages of all these isolates were also determined using spoligotyping and SITVIT2 WEB database...
June 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29913189/tb-efi-a-novel-18-plex-microbead-based-method-for-prediction-of-second-line-drugs-and-ethambutol-resistance-in-mycobacterium-tuberculosis-complex
#2
Bernice J Klotoe, Barbara Molina-Moya, Harrison Magdinier Gomes, Michel K Gomgnimbou, Lorenna Oliveira Suzarte, Maria H Féres Saad, Sajid Ali, José Dominguez, Edita Pimkina, Elena Zholdybayeva, Christophe Sola, Guislaine Refrégier
Several diagnostic tests are being developed to detect drug resistance in tuberculosis. In line with previous developments detecting rifampicin and isoniazid resistance using microbead-based systems (spoligoriftyping and TB-SPRINT), we present here an assay called TB-EFI detecting mutations involved in resistance to ethambutol, fluoroquinolones and the three classical injectable drugs (kanamycin, amikacin and capreomycin) in Mycobacterium tuberculosis. The proposed test includes both wild-type and mutant probes for each targeted locus...
June 15, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29906261/a-complete-high-quality-minion-nanopore-assembly-of-an-extensively-drug-resistant-mycobacterium-tuberculosis-beijing-lineage-strain-identifies-novel-variation-in-repetitive-pe-ppe-gene-regions
#3
Arnold Bainomugisa, Tania Duarte, Evelyn Lavu, Sushil Pandey, Chris Coulter, Ben J Marais, Lachlan M Coin
A better understanding of the genomic changes that facilitate the emergence and spread of drug-resistant Mycobacterium tuberculosis strains is currently required. Here, we report the use of the MinION nanopore sequencer (Oxford Nanopore Technologies) to sequence and assemble an extensively drug-resistant (XDR) isolate, which is part of a modern Beijing sub-lineage strain, prevalent in Western Province, Papua New Guinea. Using 238-fold coverage obtained from a single flow-cell, de novo assembly of nanopore reads resulted into one contiguous assembly with 99...
June 15, 2018: Microbial Genomics
https://www.readbyqxmd.com/read/29887187/characteristics-and-outcome-of-multidrug-resistant-tuberculosis-in-a-low-incidence-area
#4
B J Gaborit, M Revest, F Roblot, Z Maakaroun-Vermesse, P Bemer, T Guimard, F Raffi, C Bourigault, D Boutoille
OBJECTIVES: To characterize multidrug-resistant tuberculosis (MDR-TB) patients treated in a low endemic area in France and to determine risk factors for resistance. We also analyzed the efficacy and tolerability of tuberculosis (TB) treatment. METHODS: Between 2002-2013, all MDR-TB patients diagnosed in western France (hospitals belonging to the GERICCO group) were retrospectively included, with a follow-up period running until 2016. A case-control study (1:2), matched according to age, sex, and year of diagnosis, was performed to assess socio-demographic and clinical data, treatment strategies, and outcomes for the MDR-TB patients and controls treated for drug-susceptible tuberculosis during the same period...
June 7, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29879908/mortality-and-associated-factors-of-patients-with-extensive-drug-resistant-tuberculosis-an-emerging-public-health-crisis-in-china
#5
Chengli Bei, Manjiao Fu, Yao Zhang, Hebin Xie, Ke Yin, Yanke Liu, Li Zhang, Bangruan Xie, Fang Li, Hua Huang, Yuhong Liu, Li Yang, Jing Zhou
BACKGROUND: Limited treatment options of extensive drug-resistant tuberculosis (XDR-TB) have led to its high mortality worldwide. Relevant data about mortality of XDR-TB patients in literature are limited and likely underestimate the real situation in China, since the majority of patients with XDR-TB are lost to follow-up after discharge from TB hospitals. In this study, we sought to investigate the mortality and associated risk factors of Human Immunodeficiency Virus (HIV)-negative patients with XDR-TB in China...
June 7, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29844043/comparison-of-in-vitro-activity-and-mic-distributions-between-the-novel-oxazolidinone-delpazolid-and-linezolid-against-multidrug-resistant-and-extensively-drug-resistant-mycobacterium-tuberculosis-in-china
#6
Zhaojing Zong, Wei Jing, Jin Shi, Shu'an Wen, Tingting Zhang, Fengmin Huo, Yuanyuan Shang, Qian Liang, Hairong Huang, Yu Pang
Oxazolidinones are efficacious in treating mycobacterial infections, including tuberculosis (TB) caused by drug-resistant Mycobacterium tuberculosis (MTB). In this study, we compared in vitro activity and minimal inhibitory concentration (MIC) distributions between delpazolid, a novel oxazolidinone, and linezolid against multidrug-resistant (MDR) and extensively drug-resistant MTB (XDR-TB) in China. Additionally, genetic mutations in 23S rRNA, rplC and rplD genes were analyzed to reveal potential mechanism(s) underlying observed oxazolidinone resistance...
May 29, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29791557/new-and-repurposed-drugs-to-treat-multidrug-and-extensively-drug-resistant-tuberculosis
#7
Denise Rossato Silva, Margareth Dalcolmo, Simon Tiberi, Marcos Abdo Arbex, Marcela Munoz-Torrico, Raquel Duarte, Lia D'Ambrosio, Dina Visca, Adrian Rendon, Mina Gaga, Alimuddin Zumla, Giovanni Battista Migliori
Multidrug-resistant and extensively drug-resistant tuberculosis (MDR-TB and XDR-TB, respectively) continue to represent a challenge for clinicians and public health authorities. Unfortunately, although there have been encouraging reports of higher success rates, the overall rate of favorable outcomes of M/XDR-TB treatment is only 54%, or much lower when the spectrum of drug resistance is beyond that of XDR-TB. Treating M/XDR-TB continues to be a difficult task, because of the high incidence of adverse events, the long duration of treatment, the high cost of the regimens used, and the drain on health care resources...
April 2018: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29783081/recent-technological-advancements-in-tuberculosis-diagnostics-a-review
#8
REVIEW
Shagun Gupta, Vipan Kakkar
Early diagnosis and on-time effective treatment are indispensable for Tuberculosis (TB) control - a life threatening infectious communicable disease. The conventional techniques for diagnosing TB normally take two to three weeks. This delay in diagnosis and further increase in detection complexity due to the emerging risks of XDR-TB (Extensively drug Resistant-TB) and MDR-TB (Multidrug Resistant-TB) are evoking interest of researchers in the field of developing rapid TB detection techniques such as biosensing and other point-of-care (POC) techniques...
September 15, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29770053/tuberculosis-drug-resistance-in-canada-2006-2016
#9
V Gallant, J Vachon, W Siu
Background: Drug-resistant strains of tuberculosis (TB) pose a serious threat to TB prevention and control efforts. The Canadian Tuberculosis Laboratory Surveillance System (CTBLSS) was created in 1998 to monitor emerging trends and patterns in TB drug resistance in Canada. Objective: To present a descriptive overview of TB drug resistance data collected through the CTBLSS for the years 2006 to 2016 in Canada, with a focus on 2016. Methods: The CTBLSS is an isolate-based surveillance system designed to collect data on TB drug resistance across Canada...
November 2, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29769160/cross-border-outbreak-of-extensively-drug-resistant-tuberculosis-linked-to-a-university-in-romania
#10
O Popovici, Ph Monk, D Chemtob, D Chiotan, P J Freidlin, R Groenheit, M Haanperä, D Homorodean, M Mansjö, E Robinson, E Rorman, G Smith, H Soini, M J Van Der Werf
Extensively drug-resistant (XDR) tuberculosis (TB) poses a threat to public health due to its complicated, expensive and often unsuccessful treatment. A cluster of three XDR TB cases was detected among foreign medical students of a Romanian university. The contact investigations included tuberculin skin testing or interferon gamma release assay, chest X-ray, sputum smear microscopy, culture, drug susceptibility testing, genotyping and whole-genome sequencing (WGS), and were addressed to students, personnel of the university, family members or other close contacts of the cases...
May 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29755957/molecular-targets-related-drug-resistance-mechanisms-in-mdr-xdr-and-tdr-mycobacterium-tuberculosis-strains
#11
REVIEW
H M Adnan Hameed, Md Mahmudul Islam, Chiranjibi Chhotaray, Changwei Wang, Yang Liu, Yaoju Tan, Xinjie Li, Shouyong Tan, Vincent Delorme, Wing W Yew, Jianxiong Liu, Tianyu Zhang
Tuberculosis (TB) is a formidable infectious disease that remains a major cause of death worldwide today. Escalating application of genomic techniques has expedited the identification of increasing number of mutations associated with drug resistance in Mycobacterium tuberculosis . Unfortunately the prevalence of bacillary resistance becomes alarming in many parts of the world, with the daunting scenarios of multidrug-resistant tuberculosis (MDR-TB), extensively drug-resistant tuberculosis (XDR-TB) and total drug-resistant tuberculosis (TDR-TB), due to number of resistance pathways, alongside some apparently obscure ones...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29721826/importance-of-differential-identification-of-mycobacterium-tuberculosis-strains-for-understanding-differences-in-their-prevalence-treatment-efficacy-and-vaccine-development
#12
REVIEW
Hansong Chae, Sung Jae Shin
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a serious global health problem in the 21st century because of its high mortality. Mtb is an extremely successful human-adapted pathogen that displays a multifactorial ability to control the host immune response and to evade killing by drugs, resulting in the breakdown of BCG vaccine-conferred anti-TB immunity and development of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mtb. Although genetic components of the genomes of the Mtb complex strains are highly conserved, showing over 99% similarity to other bacterial genera, recently accumulated evidence suggests that the genetic diversity of the Mtb complex strains has implications for treatment outcomes, development of MDR/XDR Mtb, BCG vaccine efficacy, transmissibility, and epidemiological outbreaks...
May 2018: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/29710471/recent-therapeutic-approaches-for-the-management-of-tuberculosis-challenges-and-opportunities
#13
REVIEW
Kiran Patil, Shashikant Bagade, Smita Bonde, Sanjay Sharma, Gaurav Saraogi
Tuberculosis is a highly contagious disease spread by Mycobacterium tuberculosis. It is responsible for highest numbers of death and soon will surpass the deaths caused by HIV. The pandemic disease causes, estimated 10.4 million new infections, among which 5.9 million were men, 3.5 million were women, 1.0 million were children and the HIV patients co-infected with tuberculosis accounted for 1.2 million of all new cases in 2015, alone. The increased number of drug resistant (MDR/XDR) strains and the failure of the conventional regimens against this strain are the challenges of the coming decades...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29686156/metabolism-of-sklb-tb1001-a-potent-antituberculosis-agent-in-animals
#14
Lu Xiong, Chao Gao, Yao-Jie Shi, Xin Tao, Cui-Ting Peng, Juan Rong, Kun-Lin Liu, Qian Lei, Yi-Wen Zhang, Ning-Yu Wang, Luo-Ting Yu
Tuberculosis (TB) is a major global health problem, and the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains has increased the difficulty of treating this disease. Among the novel antituberculosis drugs in the pipeline, decaprenylphosphoryl-beta-D-ribose-2-epimerase (DprE1) inhibitors such as BTZ043 and pBTZ169 exhibited extraordinary antituberculosis potency. Herein, the metabolites of the new DprE1 inhibitor SKLB-TB1001 in vivo and its inhibition of cytochrome P450 isoforms and plasma protein binding (PPB) in vitro were studied...
April 23, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29685458/prevalence-of-drug-resistant-tuberculosis-and-imputed-burden-in-south-africa-a-national-and-sub-national-cross-sectional-survey
#15
Nazir Ahmed Ismail, Lindiwe Mvusi, Ananta Nanoo, Andries Dreyer, Shaheed V Omar, Sanni Babatunde, Thabo Molebatsi, Martie van der Walt, Adeboye Adelekan, Varough Deyde, Chikwe Ihekweazu, Shabir A Madhi
BACKGROUND: Globally, per-capita, South Africa reports a disproportionately high number of cases of multidrug-resistant (MDR) tuberculosis and extensively drug-resistant (XDR) tuberculosis. We sought to estimate the prevalence of resistance to tuberculosis drugs in newly diagnosed and retreated patients with tuberculosis provincially and nationally, and compared these with the 2001-02 estimates. METHODS: A cross-sectional survey was done between June 15, 2012-June 14, 2014, using population proportionate randomised cluster sampling in the nine provinces in South Africa...
April 20, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29663870/identification-of-some-novel-pyrazolo-1-5-a-pyrimidine-derivatives-as-inha-inhibitors-through-pharmacophore-based-virtual-screening-and-molecular-docking
#16
Palmi Modi, Shivani Patel, Mahesh T Chhabria
The InhA inhibitors play key role in mycolic acid synthesis by preventing the fatty acid biosynthesis pathway. In this present article, Pharmacophore modelling and molecular docking study followed by in silico virtual screening could be considered as effective strategy to identify newer enoyl-ACP reductase inhibitors. Pyrrolidine carboxamide derivatives were opted to generate pharmacophore models using HypoGen algorithm in Discovery studio 2.1. Further it was employed to screen Zinc and Minimaybridge databases to identify and design newer potent hit molecules...
May 4, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29628698/drug-resistant-skeletal-tuberculosis-in-a-tertiary-care-centre-in-south-india
#17
J Arockiaraj, G S Balaji, V M Cherian, Jepegnanam T S, B P Thomas, Joy S Michael, P M Poonnoose
Back ground: Drug resistant tuberculosis is alarmingly on the rise especially in developing countries. Skeletal tuberculosis accounts up to 10% of all extra pulmonary tuberculosis. World Health Organisation (WHO) has not formulated guidelines for the management of Multi-drug resistant skeletal tuberculosis. Results: A retrospective analysis of patients treated for musculoskeletal tuberculosis was done, to study drug resistance patterns. The outcome was assessed both clinically and radiologically...
March 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29622495/identification-of-serine-119-as-an-effective-inhibitor-binding-site-of-m-tuberculosis-ubiquitin-like-protein-ligase-pafa-using-purified-proteins-and-m-smegmatis
#18
He-Wei Jiang, Daniel M Czajkowsky, Tao Wang, Xu-De Wang, Jia-Bin Wang, Hai-Nan Zhang, Cheng-Xi Liu, Fan-Lin Wu, Xiang He, Zhao-Wei Xu, Hong Chen, Shu-Juan Guo, Yang Li, Li-Jun Bi, Jiao-Yu Deng, Jin Xie, Jian-Feng Pei, Xian-En Zhang, Sheng-Ce Tao
Owing to the spread of multidrug resistance (MDR) and extensive drug resistance (XDR), there is a pressing need to identify potential targets for the development of more-effective anti-M. tuberculosis (Mtb) drugs. PafA, as the sole Prokaryotic Ubiquitin-like Protein ligase in the Pup-proteasome System (PPS) of Mtb, is an attractive drug target. Here, we show that the activity of purified Mtb PafA is significantly inhibited upon the association of AEBSF (4-(2-aminoethyl) benzenesulfonyl fluoride) to PafA residue Serine 119 (S119)...
April 2018: EBioMedicine
https://www.readbyqxmd.com/read/29606091/a-cross-sectional-study-of-tuberculosis-drug-resistance-among-previously-treated-patients-in-a-tertiary-hospital-in-accra-ghana-public-health-implications-of-standardized-regimens
#19
Audrey Forson, Awewura Kwara, Samuel Kudzawu, Michael Omari, Jacob Otu, Florian Gehre, Bouke de Jong, Martin Antonio
BACKGROUND: Mycobacterium tuberculosis drug resistance is a major challenge to the use of standardized regimens for tuberculosis (TB) therapy, especially among previously treated patients. We aimed to investigate the frequency and pattern of drug resistance among previously treated patients with smear-positive pulmonary tuberculosis at the Korle-Bu Teaching Hospital Chest Clinic, Accra. METHODS: This was a cross-sectional survey of mycobacterial isolates from previously treated patients referred to the Chest Clinic Laboratory between October 2010 and October 2013...
April 2, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29596221/increasing-prevalence-of-pediatric-drug-resistant-tuberculosis-in-mumbai-india-and-its-outcome
#20
Miti A Shah, Ira Shah
SETTING: B.J.Wadia Hospital,Mumbai OBJECTIVE:: The prevalence and type of DR-TB was evaluated pre and post-2013 and outcome was studied. DESIGN: Descriptive retrospective study. Children were defined as having DR-TB on the basis of GeneXpert or LPA and/or drug susceptibility testing(DST) of MTB grown on culture or from contact's DST. RESULTS & CONCLUSION: The prevalence of DR-TB was 110 out of 1145 cases (9.6%) which showed an increase, compared to 5...
March 24, 2018: Pediatric Infectious Disease Journal
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