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https://www.readbyqxmd.com/read/29334205/overexpression-of-endometrial-estrogen-receptor-alpha-in-the-window-of-implantation-in-women-with-unexplained-infertility
#1
Mehran Dorostghoal, Hamid-O-Allah Ghaffari, Farideh Marmazi, Narjes Keikhah
Background: Failure in the endometrial receptivity may account for a significant number of infertility cases including unexplained infertility in women. Reduction in the endometrial estrogen receptor-alpha (ER-α) expression during implantation may be a critical event that coincides with the expression of specific genes and the formation of a receptive endometrium. The aim of the present study was to assess the expression of ER-α in the mid-secretory phase in the endometrium of women with unexplained infertility...
April 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29331450/mapping-stimulus-feature-selectivity-in-macaque-v1-by-two-photon-ca2-imaging-encoding-model-analysis-of-fluorescence-responses-to-natural-movies
#2
REVIEW
Koji Ikezoe, Mahya Amano, Shinji Nishimoto, Ichiro Fujita
In vivo calcium (Ca2+) imaging using two-photon microscopy allows activity to be monitored simultaneously from hundreds of individual neurons within a local population. While this allows us to gain important insights into how cortical neurons represent sensory information, factors such as photo-bleaching of the Ca2+ indicator limit imaging duration (and thus the numbers of stimuli that can be tested), which in turn hampers the full characterization of neuronal response properties. Here, we demonstrate that using an encoding model combined with presentation of natural movies results in detailed characterization of receptive field (RF) properties despite the relatively short time for data collection...
January 10, 2018: NeuroImage
https://www.readbyqxmd.com/read/29331232/incorporating-behavioral-and-sensory-context-into-spectro-temporal-models-of-auditory-encoding
#3
REVIEW
Stephen V David
For several decades, auditory neuroscientists have used spectro-temporal encoding models to understand how neurons in the auditory system represent sound. Derived from early applications of systems identification tools to the auditory periphery, the spectro-temporal receptive field (STRF) and more sophisticated variants have emerged as an efficient means of characterizing representation throughout the auditory system. Most of these encoding models describe neurons as static sensory filters. However, auditory neural coding is not static...
December 31, 2017: Hearing Research
https://www.readbyqxmd.com/read/29330457/spatially-selective-responses-to-kanizsa-and-occlusion-stimuli-in-human-visual-cortex
#4
Benjamin de Haas, Dietrich Samuel Schwarzkopf
Early visual cortex responds to illusory contours in which abutting lines or collinear edges imply the presence of an occluding surface, as well as to occluded parts of an object. Here we used functional magnetic resonance imaging (fMRI) and population receptive field (pRF) analysis to map retinotopic responses in early visual cortex using bar stimuli defined by illusory contours, occluded parts of a bar, or subtle luminance contrast. All conditions produced retinotopic responses in early visual field maps even though signal-to-noise ratios were very low...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330027/selective-estrogen-receptor-modulator-ormeloxifene-suppresses-embryo-implantation-via-inducing-mir-140-and-targeting-insulin-like-growth-factor-1-receptor-in-rat-uterus
#5
Vijay K Sirohi, Kanchan Gupta, Rohit Kumar, Vinay Shukla, Anila Dwivedi
Ormeloxifene, the non-steroidal SERM contraceptive, inhibits endometrial receptivity and embryo implantation via countering nidatory estrogen. However, the molecular mechanism of ormeloxifene action responsible for its contraceptive efficacy still remains unclear. Herein, we aimed to identify the miRNAs modulated under the influence of ormeloxifene and to explore their role in endometrial receptivity and embryo implantation. By doing microRNA sequencing analysis, a total of 168 miRNAs were found to be differentially expressed in uterine tissue of ormeloxifene-treated rats, on day 5 (10:00 h) of pregnancy i...
January 9, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29329955/longitudinal-predictors-of-early-language-in-infants-with-down-syndrome-a-preliminary-study
#6
Emily Mason-Apps, Vesna Stojanovik, Carmel Houston-Price, Sue Buckley
PURPOSE: Children with Down syndrome (DS) typically have marked delays in language development relative to their general cognitive development, with particular difficulties in expressive compared to receptive language. Although early social communication skills, including gestures and joint attention, have been shown to be related to later language outcomes in DS, knowledge is limited as to whether these factors exclusively predict outcomes, or whether other factors (e.g. perceptual and non-verbal skills) are involved...
January 9, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29327687/effect-of-speechreading-in-presbycusis-do-we-have-a-third-ear
#7
Luis Roque Reis, Pedro Escada
INTRODUCTION: Evidence regarding the effect of speechreading is lacking in age-related hearing loss (presbycusis). Thus, in individuals with presbycusis, this study determined whether speechreading would improve word intelligibility. Moreover, the study investigated the effect of speechreading on word intelligibility depending on hearing impairment severity. MATERIALS AND METHODS: This analytical, cross-sectional study involved two groups of individuals aged > 65 years that were enrolled by convenience sampling: 29 individuals with bilateral sensorineural hearing loss compatible with presbycusis (n=58 ears; mean age, 74...
December 30, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29327111/the-role-of-the-endometrial-receptivity-array-era-in-patients-who-have-failed-euploid-embryo-transfers
#8
J Tan, A Kan, J Hitkari, B Taylor, N Tallon, G Warraich, A Yuzpe, G Nakhuda
PURPOSE: Endometrial receptivity issues represent a potential source of implantation failure. The aim of this study was to document our experience with the endometrial receptivity array (ERA) among patients with a history of euploid blastocyst implantation failure. We investigated whether the contribution of the endometrial factor could be identified with the ERA test and if actionable results can lead to improved outcomes. METHODS: A retrospective review was performed for 88 patients who underwent ERA testing between 2014 and 2017...
January 11, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29326273/spatial-representations-of-self-and-other-in-the-hippocampus
#9
Teruko Danjo, Taro Toyoizumi, Shigeyoshi Fujisawa
An animal's awareness of its location in space depends on the activity of place cells in the hippocampus. How the brain encodes the spatial position of others has not yet been identified. We investigated neuronal representations of other animals' locations in the dorsal CA1 region of the hippocampus with an observational T-maze task in which one rat was required to observe another rat's trajectory to successfully retrieve a reward. Information reflecting the spatial location of both the self and the other was jointly and discretely encoded by CA1 pyramidal cells in the observer rat...
January 12, 2018: Science
https://www.readbyqxmd.com/read/29324776/effect-of-a-lifestyle-intervention-in-obese-infertile-women-on-cardiometabolic-health-and-quality-of-life-a-randomized-controlled-trial
#10
Lotte van Dammen, Vincent Wekker, Anne M van Oers, Meike A Q Mutsaerts, Rebecca C Painter, Aeilko H Zwinderman, Henk Groen, Cornelieke van de Beek, Anneke C Muller Kobold, Walter K H Kuchenbecker, Ron van Golde, Gerrit J E Oosterhuis, Niels E A Vogel, Ben Willem J Mol, Tessa J Roseboom, Annemieke Hoek
BACKGROUND: The prevalence of obesity, an important cardiometabolic risk factor, is rising in women. Lifestyle improvements are the first step in treatment of obesity, but the success depends on factors like timing and motivation. Women are especially receptive to advice about lifestyle before and during pregnancy. Therefore, we hypothesize that the pre-pregnancy period provides the perfect window of opportunity to improve cardiometabolic health and quality of life of obese infertile women, by means of a lifestyle intervention...
2018: PloS One
https://www.readbyqxmd.com/read/29324726/hiv-infection-and-hiv-associated-behaviors-among-persons-who-inject-drugs-20-cities-united-states-2015
#11
Janet C Burnett, Dita Broz, Michael W Spiller, Cyprian Wejnert, Gabriela Paz-Bailey
In the United States, 9% of human immunodeficiency virus (HIV) infections diagnosed in 2015 were attributed to injection drug use (1). In 2015, 79% of diagnoses of HIV infection among persons who inject drugs occurred in urban areas (2). To monitor the prevalence of HIV infection and associated behaviors among persons who inject drugs, CDC's National HIV Behavioral Surveillance (NHBS) conducts interviews and HIV testing in selected metropolitan statistical areas (MSAs) (3). The prevalence of HIV infection among persons who inject drugs in 20 MSAs in 2015 was 7%...
January 12, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29324475/bilateral-cochlear-implants-maximizing-expected-outcomes
#12
Kate E Willis, Nathan J Blum, Stephanie A Waryasz, Marilyn Augustyn
Sonia is a 4 1/12-year-old girl with Waardenburg syndrome and bilateral sensorineural hearing loss who had bilateral cochlear implants at 2 7/12 years of age. She is referred to Developmental-Behavioral Pediatrics by her speech/language pathologist because of concerns that her language skills are not progressing as expected after the cochlear implant. At the time of the implant, she communicated using approximately 20 signs and 1 spoken word (mama). At the time of the evaluation (18 months after the implant) she had approximately 70 spoken words (English and Spanish) and innumerable signs that she used to communicate...
January 10, 2018: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/29322616/development-of-methods-and-feasibility-of-using-hyperpolarized-carbon-13-imaging-data-for-evaluating-brain-metabolism-in-patient-studies
#13
Ilwoo Park, Peder E Z Larson, Jeremy W Gordon, Lucas Carvajal, Hsin-Yu Chen, Robert Bok, Mark Van Criekinge, Marcus Ferrone, James B Slater, Duan Xu, John Kurhanewicz, Daniel B Vigneron, Susan Chang, Sarah J Nelson
PURPOSE: Hyperpolarized carbon-13 (13 C) metabolic imaging is a noninvasive imaging modality for evaluating real-time metabolism. The purpose of this study was to develop and implement experimental strategies for using [1-13 C]pyruvate to probe in vivo metabolism for patients with brain tumors and other neurological diseases. METHODS: The 13 C radiofrequency coils and pulse sequences were tested in a phantom and were performed using a 3 Tesla whole-body scanner...
January 10, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29322357/community-peer-led-falls-prevention-presentations-what-do-the-experts-suggest
#14
Linda A M Khong, Richard G Berlach, Keith D Hill, Anne-Marie Hill
Falls among older adults are a major problem. Despite considerable progress in falls prevention research, older adults often show low motivation to engage in recommended preventive strategies. Peer-led falls prevention education for older adults may have potential for bridging the research evidence-practice gap, thereby promoting the uptake of falls prevention strategies. We evaluated peer educators' presentations of falls prevention education to community-dwelling older adults in regard to established criteria that were consistent with adult learning principles, the framework of health behaviour change, falls prevention guidelines, and recommendations for providing falls prevention information...
January 10, 2018: Journal of Primary Prevention
https://www.readbyqxmd.com/read/29321701/psychotherapy-playing-the-three-monkeys-in-mental-health-service-provision
#15
Çiğdem Dereboy, Hakan Şenel, Cennet Şafak Öztürk, Mehmet Şakiroğlu, Mehmet Eskin
Introduction: The purpose of the present study was to investigate the effect of sociodemographic variables on the knowledge of, demand for, and reception of psychotherapy as a treatment modality among psychiatric outpatients. Methods: Participants of the study were 240 psychiatric outpatients (170 females and 70 males). Data for mental health services were collected from a subgroup of 103 "experienced" patients (42.9%) having had received psychiatric help previously...
December 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29319820/embryo-implantation-war-in-times-of-love
#16
Nancy Ashary, Abhishek Tiwari, Deepak Modi
Contrary to widespread belief, the implantation of an embryo for the initiation of pregnancy is like a battle, in that the embryo uses a variety of coercive tactics to force its acceptance by the endometrium. We propose that embryo implantation involves a three step process: 1) identification of a receptive endometrium; 2) superimposition of a blastocyst-derived signature onto the receptive endometrium prior to implantation; and finally 3) breaching by the embryo and trophoblast invasion, culminating in decidualization and placentation...
January 8, 2018: Endocrinology
https://www.readbyqxmd.com/read/29318657/crystal-structure-of-tetrameric-human-rabin8-gef-domain
#17
Melanie Vetter, Niels Boegholm, Anni Christensen, Sagar Bhogaraju, Marie B Andersen, Anna Lorentzen, Esben Lorentzen
Rab GTPases and their effectors, activators and guanine nucleotide exchange factors (GEFs) are essential for vesicular transport. Rab8 and its GEF Rabin8 function in formation of the cilium organelle important for developmental signaling and sensory reception. Here we show by size exclusion chromatography and analytical ultracentrifugation that Rabin8 exists in equilibrium between dimers and tetramers. The crystal structure of tetrameric Rabin8 GEF domain reveals an occluded Rab8 binding site suggesting that this oligomer is enzymatically inactive, a notion we verify experimentally using Rabin8/Rab8 GEF assays...
January 10, 2018: Proteins
https://www.readbyqxmd.com/read/29318085/exploring-older-adult-ed-fall-patients-understanding-of-their-fall-a-qualitative-study
#18
Kalpana N Shankar, Devon Taylor, Caroline T Rizzo, Shan W Liu
Objective: We sought to understand older patients' perspectives about their fall, fall risk factors, and attitude toward emergency department (ED) fall-prevention interventions. Methods: We conducted semistructured interviews between July 2015 and January 2016 of community-dwelling, nondemented patients in the ED, who presented with a fall to an urban, teaching hospital. Interviews were halted once we achieve thematic saturation with the data coded and categorized into themes...
December 2017: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/29317175/premature-progesterone-rise-in-art-cycles
#19
REVIEW
B Lawrenz, L Melado, H M Fatemi
Premature rise of progesterone during the late follicular phase in stimulated IVF cycles is a frequent event and its effect on the endometrial receptivity and on the ART (Assisted Reproductive Technique) - outcome has become a matter of intense debate and research. An emerging body of evidence demonstrates that premature progesterone rise does have a negative impact on the outcome of the ART-success. Until now, the exact cause of progesterone elevation is not fully clear, however lately published studies points to the fact, that premature progesterone elevation might be caused by enhanced FSH stimulation...
January 6, 2018: Reproductive Biology
https://www.readbyqxmd.com/read/29316421/the-role-of-hippocampal-replay-in-memory-and%C3%A2-planning
#20
REVIEW
H Freyja Ólafsdóttir, Daniel Bush, Caswell Barry
The mammalian hippocampus is important for normal memory function, particularly memory for places and events. Place cells, neurons within the hippocampus that have spatial receptive fields, represent information about an animal's position. During periods of rest, but also during active task engagement, place cells spontaneously recapitulate past trajectories. Such 'replay' has been proposed as a mechanism necessary for a range of neurobiological functions, including systems memory consolidation, recall and spatial working memory, navigational planning, and reinforcement learning...
January 8, 2018: Current Biology: CB
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