Xiaohua Yang, Xin Yi, Fenglin Zhang, Fan Li, Limin Lang, Mingfa Ling, Xumin Lai, Lin Chen, Lulu Quan, Yiming Fu, Shengchun Feng, Gang Shu, Lina Wang, Xiaotong Zhu, Ping Gao, Qingyan Jiang, Songbo Wang
The mechanisms whereby fish oil rich in EPA and DHA promotes BAT thermogenesis and WAT browning are not fully understood. Thus, this study aimed to investigate the effects of cytochrome P450 (CYP) epoxygenase-derived EPA and DHA oxylipins 17,18-EpETE and 19,20-EpDPE on BAT thermogenesis and WAT browning and explore the underlying mechanism. Stromal vascular cells (SVCs) were subjected to 17,18-EpETE or 19,20-EpDPE treatment and mice were treated with the CYP epoxygenase inhibitor, the thermogenic marker genes were detected and the involvement of GPR120 and AMPKα were assessed...
February 7, 2022: Food & Function