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https://www.readbyqxmd.com/read/27925443/graphene-fe3o4-nanocomposites-as-efficient-anodes-to-boost-the-lifetime-and-current-output-of-microbial-fuel-cells
#1
Rong-Bin Song, Cui-E Zhao, Pan-Pan Gai, Dan Guo, Li-Ping Jiang, Qichun Zhang, Jianrong Zhang, Jun-Jie Zhu
Enhancing microbial activity and electrocatalysis through new anode material design is essential for developing microbial fuel cells (MFCs) with longer lifetimes and higher output. In this research, a novel anode material, graphene/Fe3O4 (G/Fe3O4) composite, has been designed for Shewanella-inoculated MFCs. Because Shewanella species could bind to Fe3O4 with high affinity and their growth could be well supported by Fe3O4, the bacterial cells attached quickly onto the anode surface, and their long-term activity improved...
December 7, 2016: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/27924507/tppu-protects-tau-from-h2o2-induced-hyperphosphorylation-in-hek293-tau-cells-by-regulating-pi3k-akt-gsk-3%C3%AE-pathway
#2
En-Sheng Yao, Yan Tang, Xing-Hua Liu, Ming-Huan Wang
Neurofibrillary pathology of abnormally hyperphosphorylated tau is a hallmark of Alzheimer's disease (AD) and other tauopathies. Phosphatidylinositol 3-kinase (PI3K)/Akt/glycogen synthase kinase-3 beta (GSK-3β) signaling pathway is pivotal for tau phosphorylation. Inhibition of soluble epoxide hydrolase (sEH) metabolism has been shown to effectively increase the accumulation of epoxyeicosatrienoic acids (EETs), which are cytochrome P450 metabolites of arachidonic acid and have been demonstrated to have neuroprotective effects...
December 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/27924259/cation-limited-kinetic-model-for-microbial-extracellular-electron-transport-via-an-outer-membrane-cytochrome-c-complex
#3
REVIEW
Akihiro Okamoto, Yoshihide Tokunou, Junki Saito
Outer-membrane c-type cytochrome (OM c-Cyt) complexes in several genera of iron-reducing bacteria, such as Shewanella and Geobacter, are capable of transporting electrons from the cell interior to extracellular solids as a terminal step of anaerobic respiration. The kinetics of this electron transport has implications for controlling the rate of microbial electron transport during bioenergy or biochemical production, iron corrosion, and natural mineral cycling. Herein, we review the findings from in-vivo and in-vitro studies examining electron transport kinetics through single OM c-Cyt complexes in Shewanella oneidensis MR-1...
2016: Biophysics and Physicobiology
https://www.readbyqxmd.com/read/27922726/bichromophoric-compounds-with-orthogonally-and-parallelly-arranged-chromophores-separated-by-rigid-spacers
#4
Dirk N H Meineke, Mariano L Bossi, Haisen Ta, Vladimir N Belov, Stefan W Hell
Electronic energy transfer (EET) between chromophores is of fundamental importance for many biological processes and optoelectronic devices. However, common models fall short in fully describing the process, especially in bichromophoric model systems with a donor and acceptor connected by a rigid linker providing perpendicular geometries. Herein, we report a novel strategy to prepare bichromophores containing adamantane or 2-(2-adamantylidene)-adamantane as rigid spacers, providing a fixed distance between chromophores, and their parallel or perpendicular arrangement without chromophore rotation...
December 6, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27916259/cyp-genetic-variants-cyp-metabolite-levels-and-neurologic-deterioration-in-acute-ischemic-stroke-in-chinese-population
#5
Xingyang Yi, Jing Lin, Chun Wang, Qiang Zhou
BACKGROUND: The mechanisms of neurologic deterioration (ND) are not fully understood. The aim of the present study was to evaluate the relationship between CYP genetic variants and CYP metabolite levels with ND in acute ischemic stroke patients. METHODS: Eleven single nucleotide polymorphisms (SNPs) of seven CYP genes were genotyped in 396 patients with acute ischemic stroke. The CYP plasma metabolite levels (20-hydroxyeicosatetraenoic acid [HETE], total epoxyeicosatrienoic acids [EETs], and dihydroxyeicosatrienoic acids [DiHETEs]) were also assessed...
December 1, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27901326/tuberculuma-sellae-meningiomas-a-systematic-review-of-transcranial-approaches-in-the-endoscopic-era
#6
Mazda Turel, Georgios Tsermoulas, Abdulmounem Yasssin-Kassab, Deven Reddy, Hugo Andrade-Barazarte, Lior Gonen, Gelareh Zadeh, Fred Gentili
INTRODUCTION: With the advent of skull base endoscopy, tuberculum sellae meningiomas (TSMs) are currently operated both from the traditional transcranial (TC) route as well as the extended endonasal endoscopic trasnssphenoidal approach (EETS). The aim of this study was to conduct a systematic review of TSMs excised via the TC route in the modern era when the EETS excision is gaining popularity. EVIDENCE ACQUISITION: We performed a systematic review in the medical literature following the PRISMA guidelines...
November 30, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27884766/mechanisms-of-vascular-dysfunction-in-copd-and-effects-of-a-novel-soluble-epoxide-hydrolase-inhibitor-in-smokers
#7
Lucy Yang, Joseph Cheriyan, David D Gutterman, Ruth J Mayer, Zsuzsanna Ament, Jules L Griffin, Aili L Lazaar, David E Newby, Ruth Tal-Singer, Ian B Wilkinson
BACKGROUND: Smoking and chronic obstructive pulmonary disease (COPD) are risk factors for cardiovascular disease, and the pathogenesis may involve endothelial dysfunction. We tested the hypothesis that endothelium-derived epoxyeicosatrienoic acid (EET)-mediated endothelial function is impaired in patients with COPD, and a novel sEH inhibitor GSK2256294 attenuates EET-mediated endothelial dysfunction in human resistance vessels both in vitro and in vivo. METHODS: Endogenous and stimulated endothelial release of EETs was assessed in 12 COPD patients, 11 overweight smokers, and 2 matched control groups, using forearm plethysmography with intra-arterial infusions of fluconazole, bradykinin, and the combination...
November 21, 2016: Chest
https://www.readbyqxmd.com/read/27878278/alteration-of-epoxyeicosatrienoic-acids-in-the-liver-and-kidney-of-cytochrome-p450-4f2-transgenic-mice
#8
Bijun Zhang, Guangrui Lai, Xiaoliang Liu, Yanyan Zhao
Arachidonic acid (AA) can be metabolized into 20-hydroxyeicosatetraenoic acid (20-HETE) by ω-hydroxylases, and epoxyeicosatrienoic acids (EETs) by epoxygenases. The effects of EETs in cardiovascular physiology are vasodilatory, anti-inflammatory and anti‑apoptotic, which are opposite to the function to 20‑HETE. However, EETs are not stable in vivo, and are rapidly degraded to the biologically less active metabolites, dihydroxyeicosatrienoic acids, via soluble epoxide hydrolase (sEH). Western blotting, reverse transcription‑quantitative polymerase chain reaction and liquid chromatography tandem mass spectrometry were performed in order to determine target RNA and protein expression levels...
November 23, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27870324/high-biofilm-conductivity-maintained-despite-anode-potential-changes-in-a-geobacter-enriched-biofilm
#9
Bipro Ranjan Dhar, Hodon Ryu, Hao Ren, Jorge W Santo Domingo, Junkseck Chae, Hyung-Sool Lee
This study systematically assessed intracellular electron transfer (IET) and extracellular electron transfer (EET) kinetics with respect to anode potential (Eanode ) in a mixed-culture biofilm anode enriched with Geobacter spp. High biofilm conductivity (0.96-1.24 mS cm(-1) ) was maintained during Eanode changes from -0.2 to +0.2 V versus the standard hydrogen electrode (SHE), although the steady-state current density significantly decreased from 2.05 to 0.35 A m(-2) in a microbial electrochemical cell...
November 21, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27847570/parasellar-extension-grades-and-surgical-extent-in-endoscopic-endonasal-transsphenoidal-surgery-for-pituitary-adenomas-a-single-surgeon-s-consecutive-series-with-the-aspects-of-reliability-and-clinical-validity
#10
Sang-Hyo Lee, Jae-Sung Park, Song Lee, Sung-Won Kim, Yong-Kil Hong
OBJECTIVE: The inter-rater reliability of the modified Knosp's classification was measured before the analysis. The clinical validity of the parasellar extension grading system was evaluated by investigating the extents of resection and complication rates among the grades in the endoscopic endonasal transsphenoidal surgery (EETS) for pituitary adenomas. METHODS: From November 2008 to August 2015, of the 286 patients who underwent EETS by the senior author, 208 were pituitary adenoma cases (146 non-functioning pituitary adenomas, 10 adrenocorticotropic hormone-secreting adenomas, 31 growth hormone-secreting adenomas, 17 prolactin-secreting adenomas, and 4 thyroid-stimulating hormone-secreting adenomas; 23 microadenomas, 174 macroadenomas, and 11 giant adenomas)...
November 2016: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/27815261/soluble-epoxide-hydrolase-deficiency-or-inhibition-enhances-murine-hypoxic-pulmonary-vasoconstriction-after-lipopolysaccharide-challenge
#11
Martin Wepler, Arkadi Beloiartsev, Mary D Buswell, Dipak Panigrahy, Rajeev Malhotra, Emmanuel S Buys, Peter Radermacher, Fumito Ichinose, Donald B Bloch, Warren M Zapol
RATIONALE: Hypoxic pulmonary vasoconstriction (HPV) is the response of the pulmonary vasculature to low levels of alveolar oxygen. HPV improves systemic arterial oxygenation by matching pulmonary perfusion to ventilation during alveolar hypoxia, and is impaired in lung diseases such as the acute respiratory distress syndrome (ARDS) and in experimental models of endotoxemia. Epoxyeicosatrienoic acids (EETs) are pulmonary vasoconstrictors, which are metabolized to less vasoactive dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH)...
November 4, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27797183/the-roles-of-biofilm-conductivity-and-donor-substrate-kinetics-in-a-mixed-culture-biofilm-anode
#12
Hyung-Sool Lee, Bipro Ranjan Dhar, Junyeong An, Bruce E Rittmann, Hodon Ryu, Jorge W Santo Domingo, Hao Ren, Junseok Chae
We experimentally assessed the kinetics and thermodynamics of electron transfer (ET) from the donor substrate (acetate) to the anode for a mixed-culture biofilm anode. We interpreted the results with a modified biofilm-conduction model consisting of three ET steps is series: (1) intracellular ET, (2) non-Ohmic extracellular ET (EET) from an outer membrane protein to an extracellular cofactor (EC), and (3) ET from the EC to the anode by Ohmic-conduction in the biofilm matrix. The steady-state current density was 0...
October 31, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27795395/exported-epoxide-hydrolases-modulate-erythrocyte-vasoactive-lipids-during-plasmodium-falciparum-infection
#13
Natalie J Spillman, Varun K Dalmia, Daniel E Goldberg
: Erythrocytes are reservoirs of important epoxide-containing lipid signaling molecules, including epoxyeicosatrienoic acids (EETs). EETs function as vasodilators and anti-inflammatory modulators in the bloodstream. Bioactive EETs are hydrolyzed to less active diols (dihydroxyeicosatrienoic acids) by epoxide hydrolases (EHs). The malaria parasite Plasmodium falciparum infects host red blood cells (RBCs) and exports hundreds of proteins into the RBC compartment. In this study, we show that two parasite epoxide hydrolases, P falciparum epoxide hydrolases 1 (PfEH1) and 2 (PfEH2), both with noncanonical serine nucleophiles, are exported to the periphery of infected RBCs...
October 18, 2016: MBio
https://www.readbyqxmd.com/read/27787972/nanoelectronic-investigation-reveals-the-electrochemical-basis-of-electrical-conductivity-in-shewanella-and-geobacter
#14
Mengning Ding, Hui-Ying Shiu, Shiue-Lin Li, Calvin K Lee, Gongming Wang, Hao Wu, Nathan O Weiss, Thomas D Young, Paul S Weiss, Gerard C L Wong, Kenneth H Nealson, Yu Huang, Xiangfeng Duan
The electrical conductivity measured in Shewanella and Geobacter spp. is an intriguing physical property that is the fundamental basis for possible extracellular electron transport (EET) pathways. There is considerable debate regarding the origins of the electrical conductivity reported in these microbial cellular structures, which is essential for deciphering the EET mechanism. Here, we report systematic on-chip nanoelectronic investigations of both Shewanella and Geobacter spp. under physiological conditions to elucidate the complex basis of electrical conductivity of both individual microbial cells and biofilms...
October 27, 2016: ACS Nano
https://www.readbyqxmd.com/read/27782740/vasodilatory-responses-of-renal-interlobular-arteries-to-epoxyeicosatrienoic-acids-analog-are-not-enhanced-in-ren-2-transgenic-hypertensive-rats-evidence-against-a-role-of-direct-vascular-effects-of-epoxyeicosatrienoic-acids-in-progression-of-experimental-heart
#15
A Sporková, Z Husková, P Škaroupková, N R Reddy, J R Falck, J Sadowski, L Červenka
Pathophysiological mechanisms underlying the development of renal dysfunction and progression of congestive heart failure (CHF) remain poorly understood. Recent studies have revealed striking differences in the role of epoxyeicosatrienoic acids (EETs), active products of cytochrome P-450-dependent epoxygenase pathway of arachidonic acid, in the progression of aorto-caval fistula (ACF)-induced CHF between hypertensive Ren-2 renin transgenic rats (TGR) and transgene-negative normotensive Hannover Sprague-Dawley (HanSD) controls...
October 26, 2016: Physiological Research
https://www.readbyqxmd.com/read/27753791/soluble-epoxide-hydrolase-inhibitor-attenuates-lipopolysaccharide-induced-acute-lung-injury-and-improves-survival-in-mice
#16
Yong Zhou, Tian Liu, Jia-Xi Duan, Ping Li, Guo-Ying Sun, Yong-Ping Liu, Jun Zhang, Liang Dong, Kin Sing Stephen Lee, Bruce D Hammcok, Jian-Xin Jiang, Cha-Xiang Guan
Acute lung injury (ALI) is characterized by rapid alveolar injury, vascular leakage, lung inflammation, neutrophil accumulation, and induced cytokines production leading to lung edema. The mortality rate of patients suffering from ALI remains high. Epoxyeicosatrienoic acids (EETs) are cytochrome P450-dependent derivatives of polyunsaturated fatty acid (PUFA) with anti-hypertensive, profibrinolytic and anti-inflammatory functions. EETs are rapidly hydrated by soluble epoxide hydrolase (sEH) to their less potent diols...
October 6, 2016: Shock
https://www.readbyqxmd.com/read/27723849/resonant-excitation-energy-transfer-from-carbon-dots-to-different-sized-silver-nanoparticles
#17
Roopali Prajapati, Arpan Bhattacharya, Tushar Kanti Mukherjee
The influence of size on the efficiency of the nanometal surface energy transfer (NSET) process between excited donors and different sized metal nanoparticles (NPs) is poorly explored in the literature. Here we present a systematic study by correlating the size of silver nanoparticles (Ag NPs) with the efficiency of excitation energy transfer (EET) from carbon dots (CDs) to Ag NPs. Three different sized citrate-capped Ag NPs with a mean hydrodynamic diameter of 39.91 ± 1.03, 53.12 ± 0.31 and 61.84 ± 0.77 nm have been synthesized for the present study...
October 10, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27702689/screening-of-soluble-epoxide-hydrolase-inhibitory-ingredients-from-traditional-chinese-medicines-for-anti-inflammatory-use
#18
Jun-Yan Liu, Christophe Morisseau, Huazhang Huang, Bruce D Hammock
ETHNOPHARMACOLOGICAL RELEVANCE: Inhibition of soluble epoxide hydrolase (sEH) has been extensively reported to be anti-inflammatory in multiple animal models. Some anti-inflammatory traditional Chinese medicines (TCMs) and a few natural compounds were also found to be inhibitory to sEH in vitro. AIM OF THE STUDY: To determine whether the active intergradient (AI) against sEH of anti-inflammatory TCMs in vitro is anti-inflammatory in vivo and the sEH inhibitory action of the AI contributes to its anti-inflammatory effect in vivo...
October 1, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27696333/soluble-epoxide-hydrolase-inhibitor-suppresses-the-expression-of-triggering-receptor-expressed-on-myeloid-cells-1-by-inhibiting-nf-kb-activation-in-murine-macrophage
#19
Liang Dong, Yong Zhou, Zhao-Qiong Zhu, Tian Liu, Jia-Xi Duan, Jun Zhang, Ping Li, Bruce D Hammcok, Cha-Xiang Guan
Triggering receptors expressed on myeloid cell-1 (TREM-1) is a superimmunoglobulin receptor expressed on myeloid cells. TREM-1 amplifies the inflammatory response. Epoxyeicosatrienoic acids (EETs), the metabolites of arachidonic acid derived from the cytochrome P450 enzyme, have anti-inflammatory properties. However, the effects of EETs on TREM-1 expression under inflammatory stimulation remain unclear. Therefore, inhibition of soluble epoxide hydrolase (sEH) with a highly selective inhibitor [1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea, TPPU] was used to stabilize EETs...
October 1, 2016: Inflammation
https://www.readbyqxmd.com/read/27683613/cyp2c44-gene-disruption-exacerbated-pulmonary-hypertension-and-heart-failure-in-female-but-not-male-mice
#20
Sachindra Raj Joshi, Anand Lakhkar, Vidhi Dhagia, Ariadne L Zias, Vasiliki Soldatos, Kaori Oshima, Houli Jiang, Katherine Gotlinger, Jorge H Capdevila, Michal L Schwartzman, Ivan F McMurtry, Sachin A Gupte
Epoxyeicosatrienoicacids (EETs), synthesized from arachidonic acid by epoxygenases of the CYP2C and CYP2J gene subfamilies, contribute to hypoxic pulmonary vasoconstriction (HPV) in mice. Despite their roles in HPV, it is controversial whether EETs mediate or ameliorate pulmonary hypertension (PH). A recent study showed that deficiency of Cyp2j did not protect male and female mice from hypoxia-induced PH. Since CYP2C44 is a functionally important epoxygenase, we hypothesized that knockout of the Cyp2c44 gene would protect both sexes of mice from hypoxia-induced PH...
September 2016: Pulmonary Circulation
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