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https://www.readbyqxmd.com/read/27917560/is-best-worst-scaling-suitable-for-health-state-valuation-a-comparison-with-discrete-choice-experiments
#1
Nicolas Krucien, Verity Watson, Mandy Ryan
Health utility indices (HUIs) are widely used in economic evaluation. The best-worst scaling (BWS) method is being used to value dimensions of HUIs. However, little is known about the properties of this method. This paper investigates the validity of the BWS method to develop HUI, comparing it to another ordinal valuation method, the discrete choice experiment (DCE). Using a parametric approach, we find a low level of concordance between the two methods, with evidence of preference reversals. BWS responses are subject to decision biases, with significant effects on individuals' preferences...
December 4, 2016: Health Economics
https://www.readbyqxmd.com/read/27905865/transient-bone-marrow-edema-syndrome-versus-osteonecrosis-perfusion-patterns-at-dynamic-contrast-enhanced-mr-imaging-with-high-temporal-resolution-can-allow-differentiation
#2
Tobias Geith, Thomas Niethammer, Stefan Milz, Olaf Dietrich, Maximilian Reiser, Andrea Baur-Melnyk
Purpose To prospectively evaluate the perfusion patterns at quantitative dynamic contrast material-enhanced (DCE) magnetic resonance (MR) imaging of transient bone marrow edema syndrome (TBMES) and avascular osteonecrosis. Materials and Methods Institutional review board approval and written informed consent were obtained. Thirty-two patients (21 men, 11 women; mean age, 48 years; 26 hips, 10 knees) underwent conventional MR imaging and a dynamic contrast-enhanced three-dimensional spoiled gradient-echo sequence at 3 T...
December 1, 2016: Radiology
https://www.readbyqxmd.com/read/27904441/dynamic-contrast-enhanced-ultrasound-of-the-bowel-wall-with-quantitative-assessment-of-crohn-s-disease-activity-in-childhood
#3
Damjana Kljucevsek, Dubravka Vidmar, Darja Urlep, Rok Dezman
BACKGROUND: Contrast-enhanced ultrasound (CEUS) has become an established non-invasive, patient-friendly imaging technique which improves the characterization of lesions. In addition, dynamic contrast-enhanced ultrasound (DCE-US) provides valuable information concerning perfusion of examined organs. This review addresses current applications of CEUS in children, focused on DCE-US of the bowel wall in patients with Crohn disease, which enables realtime assessment of the bowel wall vascularity with semi-quantitative and quantitative assessment of disease activity and response to medical treatment...
December 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27902592/dynamic-contrast-enhanced-breast-magnetic-resonance-imaging-for-the-prediction-of-early-and-late-recurrences-in-breast-cancer
#4
Eun Jung Choi, HyeMi Choi, Sin Ae Choi, Ji Hyun Youk
The aim of the study was to evaluate dynamic contrast-enhanced breast magnetic resonance imaging (DCE-MRI) features for the prediction of early and late recurrences in patients with breast cancer.Of 1030 breast cancer patients who underwent surgery at our hospital from January 2007 to July 2011, 83 recurrent breast cancer patients were enrolled in this study. We compared MRI features (background parenchymal enhancement [BPE], internal enhancement, adjacent vessel sign, whole-breast vascularity, initial enhancement pattern, kinetic curve types, and quantitative kinetic parameters) and clinico-pathologic variables (age, stage, histologic grade, nuclear grade, existence of lymphovascular invasion and extensive intraductal carcinoma component, and immunohistochemical profiles) between patients with early (≤2...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27898602/novel-high-spatiotemporal-resolution-versus-standard-of-care-dynamic-contrast-enhanced-breast-mri-comparison-of-image-quality
#5
Courtney K Morrison, Leah C Henze Bancroft, Wendy B DeMartini, James H Holmes, Kang Wang, Ryan J Bosca, Frank R Korosec, Roberta M Strigel
OBJECTIVE: Currently, dynamic contrast-enhanced (DCE) breast magnetic resonance imaging (MRI) prioritizes spatial resolution over temporal resolution given the limitations of acquisition techniques. The purpose of our intrapatient study was to assess the ability of a novel high spatial and high temporal resolution DCE breast MRI method to maintain image quality compared with the clinical standard-of-care (SOC) MRI. MATERIALS AND METHODS: Thirty patients, each demonstrating a focal area of enhancement (29 benign, 1 cancer) on their SOC MRI, consented to undergo a research DCE breast MRI on a second date...
November 28, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27896628/clinical-translation-of-tumor-acidosis-measurements-with-acidocest-mri
#6
Kyle M Jones, Edward A Randtke, Eriko S Yoshimaru, Christine M Howison, Pavani Chalasani, Robert R Klein, Setsuko K Chambers, Phillip H Kuo, Mark D Pagel
PURPOSE: We optimized acido-chemical exchange saturation transfer (acidoCEST) magnetic resonance imaging (MRI), a method that measures extracellular pH (pHe), and translated this method to the radiology clinic to evaluate tumor acidosis. PROCEDURES: A CEST-FISP MRI protocol was used to image a flank SKOV3 tumor model. Bloch fitting modified to include the direct estimation of pH was developed to generate parametric maps of tumor pHe in the SKOV3 tumor model, a patient with high-grade invasive ductal carcinoma, and a patient with metastatic ovarian cancer...
November 28, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27895875/takeaways-from-pre-contrast-t1-and-t2-breast-magnetic-resonance-imaging-in-women-with-recently-diagnosed-breast-cancer
#7
Seung Hee Han, Yeong Yi An, Bong Joo Kang, Sung Hun Kim, Eun Jae Lee
BACKGROUND: Dynamic contrast-enhanced magnetic resonance imaging (DCE - MRI) has been widely used in the management of breast cancer, and its diagnostic value in breast imaging has been demonstrated. There have only been a few reports regarding the usefulness of pre-contrast imaging. Knowledge about clinically significant findings of preoperative, pre-contrast T1 and T2 MR images will allow more accurate decisions regarding patient treatment and management. OBJECTIVES: The aim of this study was to evaluate the clinically significant findings of preoperative, pre-contrast T1 and T2 MR images in recently diagnosed breast cancer patients...
October 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27888709/correlations-between-dce-mri-and-histopathological-parameters-in-head-and-neck-squamous-cell-carcinoma
#8
Alexey Surov, Hans Jonas Meyer, Matthias Gawlitza, Anne-Kathrin Höhn, Andreas Boehm, Thomas Kahn, Patrick Stumpp
BACKGROUND: Dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) can characterize perfusion and vascularization of tissues. DCE MRI parameters can differentiate between malignant and benign lesions and predict tumor grading. The purpose of this study was to correlate DCE MRI findings and various histopathological parameters in head and neck squamous cell carcinoma (HNSCC). PATIENTS AND METHODS: Sixteen patients with histologically proven HNSCC (11 cases primary tumors and in 5 patients with local tumor recurrence) were included in the study...
November 23, 2016: Translational Oncology
https://www.readbyqxmd.com/read/27888545/anti-angiogenic-therapy-affects-the-relationship-between-tumor-vascular-structure-and-function-a-correlation-study-between-micro-computed-tomography-angiography-and-dynamic-contrast-enhanced-mri
#9
Eugene Kim, Jana Kim, Gunhild Mari Maelandsmo, Berit Johansen, Siver Andreas Moestue
PURPOSE: To compare the effects of two anti-angiogenic drugs, bevacizumab and a cytosolic phospholipase A2-α inhibitor (AVX235), on the relationship between vascular structure and dynamic contrast enhanced (DCE)-MRI measurements in a patient-derived breast cancer xenograft model. METHODS: Mice bearing MAS98.12 tumors were randomized into three groups: bevacizumab-treated (n = 9), AVX235-treated (n = 9), and control (n = 8). DCE-MRI was performed pre- and post-treatment...
November 25, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27884018/blood-transfusion-during-radical-chemo-radiotherapy-does-not-reduce-tumour-hypoxia-in-squamous-cell-cancer-of-the-head-and-neck
#10
Liam Welsh, Rafal Panek, Angela Riddell, Kee Wong, Martin O Leach, Mahvash Tavassoli, Durdana Rahman, Maria Schmidt, Tara Hurley, Lorna Grove, Thomas Richards, Dow-Mu Koh, Christopher Nutting, Kevin Harrington, Kate Newbold, Shreerang Bhide
BACKGROUND: Patients with head and neck squamous cell carcinoma (HNSCC) undergoing radical chemo-radiation (CRT) frequently receive transfusion with packed red cells (PRCT) during radiotherapy on the basis that PRCT increases tumour oxygenation and overcomes hypoxia-induced radio-resistance. This is likely to be a significant oversimplification given the fact that tumour hypoxia is the result of several intrinsic and extrinsic factors, including many that are not directly related to serum haemoglobin (Hb)...
November 24, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27876537/artificial-neural-networks-approach-to-pharmacokinetic-model-selection-in-dce-mri-studies
#11
Mohammad-Reza Mohammadian-Behbahani, Ali-Reza Kamali-Asl
PURPOSE: In pharmacokinetic analysis of Dynamic Contrast Enhanced MRI data, a descriptive physiological model should be selected properly out of a set of candidate models. Classical techniques suggested for this purpose suffer from issues like computation time and general fitting problems. This article proposes an approach based on Artificial Neural Networks (ANNs) for solving these problems. METHODS: A set of three physiologically and mathematically nested models generated from the Tofts model were assumed: Model I, II and III...
November 19, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27875760/comparing-cancer-detection-rates-of-patients-undergoing-short-term-follow-up-vs-routine-follow-up-after-benign-breast-biopsies-is-follow-up-needed
#12
Donna M Plecha, Courtney Garlick, Christina Dubchuck, Cheryl Thompson, Niki Constantinou
PURPOSE: To compare cancer rates after benign breast biopsies between patients with short term imaging follow-up (STFU) and those with routine follow-up (RFU). MATERIALS & METHODS: Retrospective review of benign stereotactic, US or DCE-MRI breast biopsies. RESULTS: Of 580 lesions, 192 (33%) had STFU, and 388 (67%) had RFU. For US and mammographic detected lesions, there is no difference in cancer rates between the STFU (1 cancer, n=148) and the RFU group (0 cancer, n=365) (p=0...
November 16, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27875218/entropy-of-ultrasound-contrast-agent-velocity-fields-for-angiogenesis-imaging-in-prostate-cancer
#13
Ruud van Sloun, Libertario Demi, Arnoud Postema, Jean de la Rosette, Hessel Wijkstra, Massimo Mischi
Prostate cancer care can benefit from accurate and cost-efficient imaging modalities that are able to reveal prognostic indicators for cancer. Angiogenesis is known to play a central role in the growth of tumors towards a metastatic or a lethal phenotype.With the aim of localizing angiogenic activity in a noninvasive manner, Dynamic Contrast Enhanced Ultrasound (DCEUS) has been widely used. Usually, the passage of ultrasound contrast agents thought the organ of interest is analyzed for the assessment of tissue perfusion...
November 16, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/27873226/is-dimension-order-important-when-valuing-health-states-using-discrete-choice-experiments-including-duration
#14
Brendan Mulhern, Richard Norman, Paula Lorgelly, Emily Lancsar, Julie Ratcliffe, John Brazier, Rosalie Viney
BACKGROUND: Discrete choice experiments with duration (DCETTO) can be used to estimate utility values for preference-based measures, such as the EQ-5D-5L. For self-completion, the health dimensions are presented in a standard order. However, for valuation, this may result in order effects. Thus, it is important to understand whether health state dimension ordering affects values. The aim of this study was to examine the importance of dimension ordering on DCE values using EQ-5D-5L. METHODS: A choice experiment presenting two health profiles and a third immediate death option was developed...
November 21, 2016: PharmacoEconomics
https://www.readbyqxmd.com/read/27872484/co-occurrence-of-local-anisotropic-gradient-orientations-collage-a-new-radiomics-descriptor
#15
Prateek Prasanna, Pallavi Tiwari, Anant Madabhushi
In this paper, we introduce a new radiomic descriptor, Co-occurrence of Local Anisotropic Gradient Orientations (CoLlAGe) for capturing subtle differences between benign and pathologic phenotypes which may be visually indistinguishable on routine anatomic imaging. CoLlAGe seeks to capture and exploit local anisotropic differences in voxel-level gradient orientations to distinguish similar appearing phenotypes. CoLlAGe involves assigning every image voxel an entropy value associated with the co-occurrence matrix of gradient orientations computed around every voxel...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27865027/assessment-of-active-and-inactive-sacroiliitis-in-patients-with-ankylosing-spondylitis-using-quantitative-dynamic-contrast-enhanced-mri
#16
Mengchao Zhang, Le Zhou, Ning Huang, Hong Zeng, Songyan Liu, Lin Liu
PURPOSE: To investigate the feasibility of using quantitative dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) to differentiate the active and inactive stage of sacroiliitis and the correlation between quantitative parameters and disease activity as measured by clinical scores. MATERIALS AND METHODS: Forty-two patients with ankylosing spondylitis underwent DCE-MRI on a 3.0T MRI unit. According to the results of the blood sedimentation rate (ESR), C-reactive protein (CRP), and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the patients were grouped into inactive and active groups...
November 16, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27864568/value-of-dynamic-mri-using-the-ktrans-technique-for-assessment-of-native-kidneys-in-pre-emptive-renal-transplantation
#17
Recep Sade, Mecit Kantarci, Leyla Karaca, Aylin Okur, Hayri Ogul, Mustafa Keles, Erdem Çankaya, Arif Kursad Ayan
BACKGROUND: Different non-invasive imaging techniques such as Doppler ultrasonography and renal scintigraphy are commonly employed to assess allograft function and associated complications. However, all such methods lack sufficient specificity to discriminate between residual renal function of native kidneys. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) evaluates signal dynamics during the passage of contrast material through the renal cortex, medulla, and collecting system...
November 18, 2016: Acta Radiologica
https://www.readbyqxmd.com/read/27864008/renal-plasma-flow-rpf-measured-with-multiple-inversion-time-arterial-spin-labeling-asl-and-tracer-kinetic-analysis-validation-against-a-dynamic-contrast-enhancement-method
#18
Christopher C Conlin, Niels Oesingmann, Bradley Bolster, Yufeng Huang, Vivian S Lee, Jeff L Zhang
PURPOSE: To propose and validate a method for accurately quantifying renal plasma flow (RPF) with arterial spin labeling (ASL). MATERIALS AND METHODS: The proposed method employs a tracer-kinetic approach and derives perfusion from the slope of the ASL difference signal sampled at multiple inversion-times (TIs). To validate the method's accuracy, we performed a HIPAA-compliant and IRB-approved study with 15 subjects (9 male, 6 female; age range 24-73) to compare RPF estimates obtained from ASL to those from a more established dynamic contrast-enhanced (DCE) MRI method...
November 15, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27859874/comparison-of-conventional-dce-mri-and-a-novel-golden-angle-radial-multicoil-compressed-sensing-method-for-the-evaluation-of-breast-lesion-conspicuity
#19
Laura Heacock, Yiming Gao, Samantha L Heller, Amy N Melsaether, James S Babb, Tobias K Block, Ricardo Otazo, Sungheon G Kim, Linda Moy
PURPOSE: To compare a novel multicoil compressed sensing technique with flexible temporal resolution, golden-angle radial sparse parallel (GRASP), to conventional fat-suppressed spoiled three-dimensional (3D) gradient-echo (volumetric interpolated breath-hold examination, VIBE) MRI in evaluating the conspicuity of benign and malignant breast lesions. MATERIALS AND METHODS: Between March and August 2015, 121 women (24-84 years; mean, 49.7 years) with 180 biopsy-proven benign and malignant lesions were imaged consecutively at 3...
November 17, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27859835/differentiation-of-focal-indeterminate-marrow-abnormalities-with-multiparametric-mri
#20
Jun Seung Baik, Joon-Yong Jung, Won-Hee Jee, Chang-Woo Chun, Sun Ki Kim, Seung Han Shin, Yang Guk Chung, Chan-Kwon Jung, Stephan Kannengiesser, YoHan Sohn
PURPOSE: To explore magnetic resonance imaging (MRI) parameters from intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI), multiecho Dixon imaging (ME-Dixon), and dynamic contrast-enhanced imaging (DCE) for differentiating focal indeterminate marrow abnormalities MATERIALS AND METHODS: Forty-two patients with 14 benign and 28 malignant focal marrow abnormalities were included. The following were independently analyzed by two readers: signal intensity (SI), contour, and margin on conventional MR images; SI on b-800 images (SIb-800 ), apparent diffusion coefficient (ADC), IVIM parameters (Dslow, Dfast , and f), fat fraction (Ff), and DCE parameters (time-to-signal intensity curve pattern, iAUC, K(trans) , kep , and ve )...
November 9, 2016: Journal of Magnetic Resonance Imaging: JMRI
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