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https://www.readbyqxmd.com/read/28438713/effects-of-arterial-input-function-selection-on-kinetic-parameters-in-brain-dynamic-contrast-enhanced-mri
#1
Vera C Keil, Burkhard Mädler, Jürgen Gieseke, Rolf Fimmers, Elke Hattingen, Hans H Schild, Dariusch R Hadizadeh
PURPOSE: Kinetic parameters derived from dynamic contrast-enhanced MRI (DCE-MRI) were suggested as a possible instrument for multi-parametric lesion characterization, but have not found their way into clinical practice yet due to inconsistent results. The quantification is heavily influenced by the definition of an appropriate arterial input functions (AIF). Regarding brain tumor DCE-MRI, there are currently several co-existing methods to determine the AIF frequently including different brain vessels as sources...
April 21, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28431360/contrasting-dual-c-cl-isotope-fractionation-offers-potential-to-distinguish-reductive-chloroethene-transformation-from-breakdown-by-permanganate
#2
Eylem Doğan-Subaşı, Martin Elsner, Shiran Qiu, Stefan Cretnik, Siavash Atashgahi, Orfan Shouakar-Stash, Nico Boon, Winnie Dejonghe, Leen Bastiaens
cis-1,2-Dichloroethene (cis-DCE) and trichloroethene (TCE) are persistent, toxic and mobile pollutants in groundwater systems. They are both conducive to reductive dehalogenation and to oxidation by permanganate. In this study, the potential of dual element (C, Cl) compound specific isotope analyses (CSIA) for distinguishing between chemical oxidation and anaerobic reductive dechlorination of cis-DCE and TCE was investigated. Well-controlled cis-DCE degradation batch tests gave similar carbon isotope enrichment factors εC (‰), but starkly contrasting dual element isotope slopes Δδ(13)C/Δδ(37)Cl for permanganate oxidation (εC=-26‰±6‰, Δδ(13)C/Δδ(37)Cl≈-125±47) compared to reductive dechlorination (εC=-18‰±4‰, Δδ(13)C/Δδ(37)Cl≈4...
April 18, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28427220/multiparametric-imaging-using-18f-fdg-pet-ct-heterogeneity-parameters-and-functional-mri-techniques-prognostic-significance-in-patients-with-primary-advanced-oropharyngeal-or-hypopharyngeal-squamous-cell-carcinoma-treated-with-chemoradiotherapy
#3
Sheng-Chieh Chan, Nai-Ming Cheng, Chia-Hsun Hsieh, Shu-Hang Ng, Chien-Yu Lin, Tzu-Chen Yen, Cheng-Lung Hsu, Hung-Ming Wan, Chun-Ta Liao, Kai-Ping Chang, Jiun-Jie Wang
BACKGROUND: In this study, PET heterogeneity was combined with functional MRI techniques to refine the prediction of prognosis in patients with oropharyngeal or hypopharyngeal squamous cell carcinoma (OHSCC). METHODS: A total of 124 patients with primary advanced OHSCC who underwent pretreatment 18F-FDG PET/CT, dynamic contrast-enhanced MR imaging (DCE-MRI), and diffusion-weighted MR imaging (DWI) were enrolled. Conventional and heterogeneity parameters from 18F-FDG PET as well as perfusion parameters from DCE-MRI and diffusion parameter from DWI of primary tumors were analyzed in relation to recurrence-free survival (RFS) and overall survival (OS)...
March 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28427122/-application-on-the-quantitative-perfusion-parameters-of-dynamic-contrast-enhanced-mri-in-the-pathological-subtype-of-uterine-leiomyoma
#4
J Zheng, Z H Zhao, J F Yang, L Zhao, L M Yang, H J Hu
Objective: To analyze the value of the quantitative perfusion parameters of dynamic contrast-enhanced MRI(DCE-MRI) in the pathological subtype of uterine leiomyoma. Methods: A total of 35 cases of uterine leiomyoma confirmed by surgery and pathology were retrospectively analyzed in Shaoxing People's Hospital from October 2015 to May 2016.All cases underwent DCE-MRI. Quantitative perfusion parameters were prospectively measured and analyzed, including transfer constant (K(trans)) , efflux rate constant (K(ep)), extravascular extracellular space volume ratio (V(e)), blood plasma volume ratio (V(p)), permeability surface area product (PS) and plasma flow (F(p)) , using signal-input two-compartment tracer kinetic models (Extended Tofts model and Exchange model) in 35 leiomyoma cases...
April 18, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28425493/characterization-of-different-microbubbles-in-assisting-focused-ultrasound-induced-blood-brain-barrier-opening
#5
Sheng-Kai Wu, Po-Chun Chu, Wen-Yen Chai, Shih-Tsung Kang, Chih-Hung Tsai, Ching-Hsiang Fan, Chih-Kuang Yeh, Hao-Li Liu
Microbubbles (MBs) serve as a critical catalyst to amplify local cavitation in CNS capillary lumen to facilitate focused ultrasound (FUS) to transiently open the blood-brain barrier (BBB). However, limited understanding is available regarding the effect of different microbubbles to induce BBB opening. The aim of this study is to characterize different MBs on their effect in FUS-induced BBB opening. Three MBs, SonoVue, Definity, and USphere, were tested, with 0.4-MHz FUS exposure at 0.62-1.38 of mechanical index (MI) on rats...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28425065/changes-in-perfusion-and-diffusion-in-the-endplate-regions-of-degenerating-intervertebral-discs-a-dce-mri-study
#6
Volkan Emre Arpinar, Scott D Rand, Andrew P Klein, Dennis J Maiman, L Tugan Muftuler
No abstract text is available yet for this article.
April 19, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28425048/biopsy-targeting-with-dynamic-contrast-enhanced-versus-standard-neuronavigation-mri-in-glioma-a-prospective-double-blinded-evaluation-of-selection-benefits
#7
Vera C Keil, Bogdan Pintea, Gerrit H Gielen, Susanne Greschus, Rolf Fimmers, Jürgen Gieseke, Matthias Simon, Hans H Schild, Dariusch R Hadizadeh
Current biopsy planning based on contrast-enhanced T1W (CET1W) or FLAIR sequences frequently delivers biopsy samples that are not in concordance with the gross tumor diagnosis. This study investigates whether the quantitative information of transfer constant K(trans) maps derived from T1W dynamic contrast-enhanced MRI (DCE-MRI) can help enhance the quality of biopsy target selection in glioma. 28 patients with suspected glioma received MRI including DCE-MRI and a standard neuronavigation protocol of 3D FLAIR- and CET1W data sets (0...
April 19, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28423868/genetic-parameters-of-calving-ease-using-sire-maternal-grandsire-model-in-korean-holsteins
#8
Mahboob Alam, Choi Tae-Jeong, Choy Yun-Ho, Lee Jae-Gu, Kwang-Hyeon Cho, Chang Gwon Dang, Jae Gwan Choi, Mi Na Park, Seung Soo Lee
Objective: Calving ease (CE) is a complex reproductive trait of economic importance in dairy cattle. This study was aimed to investigate the genetic merits of CE for Holsteins in Korea. Methods: A total of 297,614 field records of CE, from 2000 to 2015, from first parity Holstein heifers were recorded initially. After necessary data pruning such as age at first calving (18-42 mo), gestation length, and presence of sire information, final datasets for CE consisted of 147,526 and 132,080 records for service sire calving ease (SCE) and daughter calving ease (DCE) evaluations, respectively...
April 19, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28421967/lung-tumor-induction-by-26-week-dermal-application-of-1-2-dichloroethane-in-cb6f1-tg-rash2-mice
#9
Mayuko Suguro, Takamasa Numano, Mayumi Kawabe, Yuko Doi, Norio Imai, Yukinori Mera, Seiko Tamano
Short-term alternatives to traditional 2-year carcinogenic studies in rodents are being actively pursued. Recently, a 26-week short-term carcinogenicity study using CB6F1-Tg rasH2@Jcl (rasH2) mice has become a worldwide standard for the evaluation of chemical carcinogenesis. However, an acceptable short-term carcinogenic study model for dermally applied products is still lacking. To investigate the suitability of using the rasH2 mouse to test carcinogenic potential, 1,2-dichloroethane (1,2-DCE) was dermally applied to rasH2 mice: 1,2-DCE is a known carcinogen that causes lung bronchiolo-alveolar adenomas and adenocarcinomas when administered topically, orally, or by inhalation exposure; 1,2-DCE at a dose level of 126 mg/mouse in 200 μl acetone or acetone alone (vehicle control) was applied to the dorsal skin of 10 mice of each sex 3 times a week for 26 weeks...
April 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28415647/contrast-agents-in-dynamic-contrast-enhanced-magnetic-resonance-imaging
#10
REVIEW
Yuling Yan, Xilin Sun, Baozhong Shen
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a noninvasive method to assess angiogenesis, which is widely used in clinical applications including diagnosis, monitoring therapy response and prognosis estimation in cancer patients. Contrast agents play a crucial role in DCE-MRI and should be carefully selected in order to improve accuracy in DCE-MRI examination. Over the past decades, there was much progress in the development of optimal contrast agents in DCE-MRI. In this review, we describe the recent research advances in this field and discuss properties of contrast agents, as well as their advantages and disadvantages...
March 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415581/tumor-physiological-changes-during-hypofractionated-stereotactic-body-radiation-therapy-assessed-using-multi-parametric-magnetic-resonance-imaging
#11
Heling Zhou, Zhang Zhang, Rebecca Denney, Jessica S Williams, Jeni Gerberich, Strahinja Stojadinovic, Debabrata Saha, John M Shelton, Ralph P Mason
Radiation therapy is a primary treatment for non-resectable lung cancer and hypoxia is thought to influence tumor response. Hypoxia is expected to be particularly relevant to the evolving new radiation treatment scheme of hypofractionated stereotactic body radiation therapy (SBRT). As such, we sought to develop non-invasive tools to assess tumor pathophysiology and response to irradiation. We applied blood oxygen level dependent (BOLD) and tissue oxygen level dependent (TOLD) MRI, together with dynamic contrast enhanced (DCE) MRI to explore the longitudinal effects of SBRT on tumor oxygenation and vascular perfusion using A549 human lung cancer xenografts in a subcutaneous rat model...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28411964/understanding-what-matters-an-exploratory-study-to-investigate-the-views-of-the-general-public-for-priority-setting-criteria-in-health-care
#12
Julie Ratcliffe, Emily Lancsar, Ruth Walker, Yuanyuan Gu
Health care policy makers internationally are increasingly expressing commitment to consultation with, and incorporation of, the views of the general public into the formulation of health policy and the process of setting health care priorities. In practice, however, there are relatively few opportunities for the general public to be involved in health care decision-making. In making resource allocation decisions, funders, tasked with managing scarce health care resources, are often faced with difficult decisions in balancing efficiency with equity considerations...
March 16, 2017: Health Policy
https://www.readbyqxmd.com/read/28410814/the-effects-of-convenience-and-quality-on-the-demand-for-vaccination-results-from-a-discrete-choice-experiment
#13
Na Guo, Guojie Zhang, Dawei Zhu, Jian Wang, Luwen Shi
BACKGROUND: Vaccination is an effective way to prevent infectious diseases. Most studies analysed people's vaccine decisions, but few studies have analysed the effects of convenience such as immunisation schedule and distance and the quality of vaccination service on vaccination uptake. OBJECTIVE: The aim of this paper was to investigate adults' preferences for convenience and quality of vaccination service, calculate the private economic benefit from convenience (vaccination schedule and distance) and quality, and predict the uptake rate for different vaccine scenarios...
April 12, 2017: Vaccine
https://www.readbyqxmd.com/read/28408008/eliciting-preferences-for-information-provision-in-newborn-bloodspot-screening-programs
#14
Stuart J Wright, Fiona Ulph, Nimarta Dharni, Katherine Payne
BACKGROUND: The national newborn bloodspot screening programs (NBSPs) are continually expanding to screen for more conditions. OBJECTIVES: To quantify parents' preferences for information and the way in which this is provided in example NBSPs. METHODS: A hybrid choice experiment, combining a conjoint analysis and a discrete choice experiment, was designed. A sample of current and future parents between the ages of 18 and 45 years was identified via an Internet panel...
April 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28406980/correction-tensor-based-multichannel-reconstruction-for-breast-tumours-identification-from-dce-mris
#15
X-X Yin, S Hadjiloucas, J-H Chen, Y Zhang, J-L Wu, M-Y Su
[This corrects the article DOI: 10.1371/journal.pone.0172111.].
2017: PloS One
https://www.readbyqxmd.com/read/28402267/contrast-enhanced-ultrasound-evaluation-of-pancreatic-cancer-xenografts-in-nude-mice-after-irradiation-with-sub-threshold-focused-ultrasound-for-tumor-ablation
#16
Yi Hui Gao, Lei Wu, Rui Wang, Qian Guo, Yi Ni Chen, Bing Hu, Li Xin Jiang
We evaluated the efficacy of contrast-enhanced ultrasound for assessing tumors after irradiation with sub-threshold focused ultrasound (FUS) ablation in pancreatic cancer xenografts in nude mice. Thirty tumor-bearing nude mice were divided into three groups: Group A received sham irradiation, Group B received a moderate-acoustic energy dose (sub-threshold), and Group C received a high-acoustic energy dose. In Group B, B-mode ultrasound (US), color Doppler US, and dynamic contrast-enhanced ultrasound (DCE-US) studies were conducted before and after irradiation...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28401265/dynamic-contrast-enhanced-mr-imaging-in-osteoid-osteoma-relationships-with-clinical-and-ct-characteristics
#17
P Pottecher, E Sibileau, S Aho, B Hamze, C Parlier, J D Laredo, V Bousson
OBJECTIVE: To correlate dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) features to clinical and computed tomography (CT) morphological features of osteoid osteoma (OO). MATERIALS AND METHODS: Our institutional review board approved this retrospective study, waiving the need for informed consent. We included the 102 patients treated with interstitial laser ablation for histologically documented OO at our institution in 2008-2013. DCE-MRI variables were the time-enhancement pattern and rising slope (Sloperise) and CT variables were the bone and segment involved (OObone and OOsegment, respectively), OO location relative to the native cortex (OOcortex), nidus surface area, vessel sign, and largest neighboring-vessel diameter (Dmaxvessel)...
April 11, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28400572/imaging-atherosclerosis-in-rheumatoid-arthritis-evidence-for-increased-prevalence-altered-phenotype-and-a-link-between-systemic-and-localised-plaque-inflammation
#18
S Skeoch, P L Hubbard Cristinacce, H Williams, P Pemberton, D Xu, J Sun, J James, C Yuan, T Hatsukami, P D Hockings, M Y Alexander, J C Waterton, I N Bruce
In rheumatoid arthritis (RA), chronic inflammation is thought to drive increased cardiovascular risk through accelerated atherosclerosis. It may also lead to a more high-risk plaque phenotype. We sought to investigate carotid plaque phenotype in RA patients using Dynamic Contrast-Enhanced MRI (DCE-MRI) and Fludeoxyglucose Positron Emission Tomography(FDG-PET). In this pilot study, RA patients and age/sex-matched controls were evaluated for cardiovascular risk factors and carotid plaque on ultrasound. Subjects with plaque >2 mm thick underwent DCE-MRI, and a subgroup of patients had FDG-PET...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28395970/dynamic-contrast-enhanced-mri-detects-changes-in-vascular-transport-rate-constants-following-treatment-with-thermally-sensitive-liposomal-doxorubicin
#19
Brett Z Fite, Azadeh Kheirolomoom, Josquin L Foiret, Jai W Seo, Lisa M Mahakian, Elizabeth S Ingham, Sarah M Tam, Alexander D Borowsky, Fitz-Roy E Curry, Katherine W Ferrara
Temperature-sensitive liposomal formulations of chemotherapeutics, such as doxorubicin, can achieve locally high drug concentrations within a tumor and tumor vasculature while maintaining low systemic toxicity. Further, doxorubicin delivery by temperature-sensitive liposomes can reliably cure local cancer in mouse models. Histological sections of treated tumors have detected red cell extravasation within tumors treated with temperature-sensitive doxorubicin and ultrasound. We hypothesize that the local release of drug into the tumor vasculature and resulting high drug concentration can alter vascular transport rate constants along with having direct tumoricidal effects...
April 7, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28376242/lung-perfusion-mri-vs-spect-for-screening-in-suspected-chronic-thromboembolic-pulmonary-hypertension
#20
Christopher S Johns, Andrew J Swift, Smitha Rajaram, Paul J C Hughes, David J Capener, David G Kiely, James M Wild
PURPOSE: To assess the diagnostic accuracy of magnetic resonance imaging (MRI) perfusion against perfusion single photon emission tomography (SPECT) screening for chronic thromboembolic pulmonary hypertension (CTEPH). Ventilation/perfusion (V/Q) scintigraphy is recommended to screen for suspected CTEPH. It has previously been shown that 3D dynamic contrast-enhanced (DCE) lung perfusion MRI has a similar sensitivity for diagnosing CTEPH in comparison to planar perfusion scintigraphy; however, planar scintigraphy has now been largely replaced by SPECT, due to higher spatial resolution and sensitivity...
April 4, 2017: Journal of Magnetic Resonance Imaging: JMRI
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