keyword
MENU ▼
Read by QxMD icon Read
search

ADC

keyword
https://www.readbyqxmd.com/read/28228636/progressive-ischemic-stroke-due-to-thyroid-storm-associated-cerebral-venous-thrombosis
#1
Natsumi Tanabe, Eiji Hiraoka, Masataka Hoshino, Gautam A Deshpande, Kana Sawada, Yasuhiro Norisue, Jumpei Tsukuda, Toshihiko Suzuki
BACKGROUND Cerebral venous thrombosis (CVT) is a rare but fatal complication of hyperthyroidism that is induced by the hypercoagulable state of thyrotoxicosis. Although it is frequently difficult to diagnose CVT promptly, it is important to consider it in the differential diagnosis when a hyperthyroid patient presents with atypical neurologic symptoms. CASE REPORT A 49-year-old Japanese female with unremarkable medical history came in with thyroid storm and multiple progressive ischemic stroke identified at another hospital...
February 23, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28227953/in-vivo-characterization-of-a-versatile-8-channel-digital-biopotential-recording-system-with-sub-%C3%AE-vrms-input-noise
#2
Oscar F Cota, Dennis Plachta, Thomas Stieglitz, Sarath Kundumattathil, Yiannos Manoli, Matthias Kuhl, Oscar F Cota, Dennis Plachta, Thomas Stieglitz, Sarath Kundumattathil, Yiannos Manoli, Matthias Kuhl, Thomas Stieglitz, Dennis Plachta, Matthias Kuhl, Oscar F Cota, Yiannos Manoli, Sarath Kundumattathil
This work presents the design and testing of an integrated 8-channel CMOS biopotential recording chip, consisting of low-noise input stages, tunable second stage, a multiplexer, and two analog-to-digital converters (ADC). Through its variable supply concept, the integrated input-referred noise of the first stage is selectable from 1.5 down to 0.63 μVRMS (ISS = 200 μA), which is superior to standard laboratory recording systems. The device features variable lower and upper corner frequencies, and outputs two digital 16-bit data streams at 62...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227813/a-110-nw-in-channel-sigma-delta-converter-for-large-scale-neural-recording-implants
#3
M Rezaei, E Maghsoudloo, M Sawan, B Gosselin, M Rezaei, E Maghsoudloo, M Sawan, B Gosselin, M Rezaei, E Maghsoudloo, M Sawan, B Gosselin
Advancement in wireless and microsystems technology have ushered in new devices that can directly interface with the central nervous system for stimulating and/or monitoring neural circuitry. In this paper, we present an ultra low-power sigma-delta analog-to-digital converter (ADC) intended for utilization into large-scale multi-channel neural recording implants. This proposed design, which provides a resolution of 9 bits using a one-bit oversampled ADC, presents several desirable features that allow for an in-channel ADC scheme, where one sigma-delta converter is provided for each channel, enabling development of scalable systems that can interface with different types of high-density neural microprobes...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227634/design-and-validation-of-a-wearable-drl-less-eeg-using-a-novel-fully-reconfigurable-architecture
#4
Ruhi Mahajan, Bashir I Morshed, Gavin M Bidelman, Ruhi Mahajan, Bashir I Morshed, Gavin M Bidelman, Bashir I Morshed, Ruhi Mahajan, Gavin M Bidelman
The conventional EEG system consists of a driven-right-leg (DRL) circuit, which prohibits modularization of the system. We propose a Lego-like connectable fully reconfigurable architecture of wearable EEG that can be easily customized and deployed at naturalistic settings for collecting neurological data. We have designed a novel Analog Front End (AFE) that eliminates the need for DRL while maintaining a comparable signal quality of EEG. We have prototyped this AFE for a single channel EEG, referred to as Smart Sensing Node (SSN), that senses brain signals and sends it to a Command Control Node (CCN) via an I(2)C bus...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227596/a-180-nm-cmos-analog-adaptive-sampler-for-blood-pressure-feature-extraction
#5
Callum Laurenson, Francois Rivet, Mehmet R Yuce, Jean-Michel Redoute, Callum Laurenson, Francois Rivet, Mehmet R Yuce, Jean-Michel Redoute, Jean-Michel Redoute, Francois Rivet, Mehmet R Yuce, Callum Laurenson
This paper presents an analogue feature detector for extraction and sampling of key-points on an arterial blood pressure signal in both humans and small mammals used as human physiological models. A CMOS integrated circuit was implemented in UMC 180nm technology, utilizing the proposed sampling method to greatly reduce the number of samples necessary for meaningful reconstruction of the low bandwidth signal. This circuit was interfaced with an external ADC to fully extract the feature points, and evaluate the system performance...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227280/a-low-power-level-crossing-adc-for-wearable-wireless-ecg-sensors
#6
Zhenzhen Tian, Rendong Ying, Peilin Liu, Guoxing Wang, Yong Lian, Zhenzhen Tian, Rendong Ying, Peilin Liu, Guoxing Wang, Yong Lian, Yong Lian, Peilin Liu, Guoxing Wang, Zhenzhen Tian, Rendong Ying
Ultra-low power consumption is desired in most wearable biomedical devices. The event-driven based Analog-to-Digital converter (ADC) could be an excellent candidate for low power system because of the reduction in sampling points for biosignals. In the existing event-driven based ADC architectures, two or more high precision comparators are utilized to sample the input signal. In this paper, we propose a new scheme utilizing only one high precision comparator to genertate samples with the assistance of a low precision one...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226889/dual-mode-cmos-analog-front-end-afe-for-electrical-impedance-spectroscopy-eis-systems
#7
Virgilio Valente, Dai Jiang, Andreas Demosthenous, Virgilio Valente, Dai Jiang, Andreas Demosthenous, Dai Jiang, Andreas Demosthenous, Virgilio Valente
This paper presents the operation of a dual-mode wideband CMOS analog front-end (AFE) for electrical impedance spectroscopy. The chip combines two current-readout (CR) channels and four voltage-readout (VR) channels suitable for both bipolar and tetrapolar EIS analysis. The chip addresses the need for flexible readout units for real-time simultaneous single-cell and large scale tissue/organ analysis. Postlayout simulations show that the VR channel is capable of wideband operation up to 12 MHz with noise floor as low as 16...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226887/an-ultra-low-power-front-end-ic-for-wearable-health-monitoring-system
#8
Yu-Pin Hsu, Zemin Liu, Mona M Hella, Yu-Pin Hsu, Zemin Liu, Mona M Hella, Yu-Pin Hsu, Mona M Hella, Zemin Liu
This paper presents a low-power front-end IC for wearable health monitoring systems. The IC, designed in a standard 0.13μm CMOS technology, fully integrates a low-noise analog front-end (AFE) to process the weak bio-signals, followed by an analog-to-digital converter (ADC) to digitize the extracted signals. An AC-coupled driving buffer, that interfaces between the AFE and the ADC is introduced to scale down the power supply of the ADC. The power consumption decreases by 50% compared to the case without power supply scaling...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226691/structural-changes-of-cingulate-cortex-in-post-stroke-depression
#9
Chenfei Ye, Jun Wu, Xuhui Chen, Changle Zhang, Hengtong Li, Shuai Mao, Heather T Ma, Chenfei Ye, Jun Wu, Xuhui Chen, Changle Zhang, Hengtong Li, Shuai Mao, Heather T Ma, Shuai Mao, Heather T Ma, Jun Wu, Hengtong Li, Changle Zhang, Chenfei Ye, Xuhui Chen
Disruption of neural connections among regions regulating mood and cognition rather than cerebrovascular lesions may contribute to post-stroke depression (PSD). In this paper, we hypothesized that structural abnormalities in white matter structure like cingulate cortex induced by focal infarcts would play a role in mood regulation or depression after stroke onset. Various DTI coefficients including FA, RD and ADC with multiple signal distribution measurements were collected and statistically analyzed. The results identify significant differences in volume and multiple diffusion indices of DTI intensity distribution in cingulate cortex between PSD patients and the normal control...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225646/conventional-and-zoomit-dwi-for-evaluation-of-testis-in-patients-with-ipsilateral-varicocele
#10
İsmail Okan Yıldırım, Semih Sağlık, Hüseyin Çelik
OBJECTIVE: The current study aimed to investigate the effects of varicocele on testis parenchyma by using ZOOMit DWI and conventional DWI and to compare both diffusion methods. SUBJECTS AND METHODS: Forty-five patients with unilateral varicocele diagnosed by physical examination and color Doppler ultrasound between July 2015 and December 2015 and 32 healthy volunteers were included in the study. ZOOMit and conventional DWI were performed for all patients with a 3-T MRI scanner...
February 22, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28225579/intravoxel-incoherent-motion-mri-assessment-of-chemoradiation-induced-pelvic-bone-marrow-changes-in-cervical-cancer-and-correlation-with-hematological-toxicity
#11
Elaine Yuen Phin Lee, Jose Angelo Udal Perucho, Vince Vardhanabhuti, Jian He, Steven Wai Kwan Siu, Siew Fei Ngu, Nina A Mayr, William T C Yuh, Queenie Chan, Pek-Lan Khong
PURPOSE: To investigate bone marrow changes after chemoradiation (CRT) using intravoxel incoherent motion magnetic resonance imaging (IVIM-MRI) and correlate imaging changes with hematological toxicity (HT) in patients with locally advanced cervical cancer. MATERIALS AND METHODS: Thirty-nine patients with newly diagnosed cervical cancer were prospectively recruited for two sequential 3.0T IVIM-MRI studies: before treatment (MRI-1) and 3-4 weeks after standardized CRT (MRI-2)...
February 22, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28225568/liver-histology-and-diffusion-weighted-mri-in-children-with-nonalcoholic-fatty-liver-disease-a-magnet-study
#12
Paul Manning, Paul Murphy, Kang Wang, Jonathan Hooker, Tanya Wolfson, Michael S Middleton, Kimberly P Newton, Cynthia Behling, Hannah I Awai, Janis Durelle, Melissa N Paiz, Jorge E Angeles, Diana De La Pena, J Allen McCutchan, Jeffrey B Schwimmer, Claude B Sirlin
PURPOSE: To determine potential associations between histologic features of pediatric nonalcoholic fatty liver disease (NAFLD) and estimated quantitative magnetic resonance diffusion-weighted imaging (DWI) parameters. MATERIALS AND METHODS: This prospective, cross-sectional study was performed as part of the Magnetic Resonance Assessment Guiding NAFLD Evaluation and Treatment (MAGNET) ancillary study to the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)...
February 22, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28225064/intravoxel-incoherent-motion-diffusion-weighted-mr-imaging-in-assessing-and-characterizing-solitary-pulmonary-lesions
#13
Qi Wan, Ying-Shi Deng, Jia-Xuan Zhou, Yu-Dong Yu, Ying-Ying Bao, Qiang Lei, Hou-Jin Chen, Ya-Hui Peng, Ying-Jie Mei, Qing-Si Zeng, Xin-Chun Li
This study aimed to investigate the potential of intravoxel incoherent motion (IVIM) diffusion-weighted MR imaging in assessing solitary pulmonary lesions (SPLs). Sixty-two patients with pathologically confirmed SPLs, including 51 and 11 cases of malignant and benign lesions, respectively, were assessed. Diffusion weighted imaging (DWI) with 13 b values was used to derive apparent diffusion coefficient (ADC) and IVIM parameters, including true diffusion coefficient (D), pseudo-diffusion coefficient (D*), and perfusion fraction (f)...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28224172/multi-parametric-mri-findings-of-granulomatous-prostatitis-developing-after-intravesical-bacillus-calmette-gu%C3%A3-rin-therapy
#14
Josh Gottlieb, Robert Princenthal, Martin I Cohen
PURPOSE: To evaluate the multi-parametric MRI (mpMRI) findings in patients with biopsy-proven granulomatous prostatitis and prior Bacillus Calmette-Guérin (BCG) exposure. MATERIALS AND METHODS: MRI was performed in six patients with pathologically proven granulomatous prostatitis and a prior history of bladder cancer treated with intravesical BCG therapy. Multi-parametric prostate MRI images were recorded on a GE 750W or Philips Achieva 3.0 Tesla MRI scanner with high-resolution, small-field-of-view imaging consisting of axial T2, axial T1, coronal T2, sagittal T2, axial multiple b-value diffusion (multiple values up to 1200 or 1400), and dynamic contrast-enhanced 3D axial T1 with fat suppression sequence...
February 21, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28223423/modulating-therapeutic-activity-and-toxicity-of-pyrrolobenzodiazepine-antibody-drug-conjugates-with-self-immolative-disulfide-linkers
#15
Thomas H Pillow, Melissa Schutten, Shang-Fan Yu, Rachana Ohri, Jack Sadowsky, Kirsten Achilles Poon, Willy Solis, Fiona Zhong, Geoffrey Del Rosario, Mary Ann T Go, Jeffery Lau, Sharon Yee, Jintang He, Luna Liu, Carl Ng, Keyang Xu, Douglas D Leipold, Amrita V Kamath, Donglu Zhang, Luke Masterson, Stephen J Gregson, Philip W Howard, Fan Fang, Jinhua Chen, Janet Gunzner-Toste, Katherine K Kozak, Susan Spencer, Paul Polakis, Andrew G Polson, John A Flygare, Jagath R Junutula
A novel disulfide linker was designed to enable a direct connection between cytotoxic pyrrolobenzodiazepine (PBD) drugs and the cysteine on a targeting antibody for use in antibody-drug conjugates (ADCs). ADCs composed of a cysteine-engineered antibody were armed with a PBD using a self-immolative disulfide linker. Both the chemical linker and the antibody site were optimized for this new bioconjugation strategy to provide a highly stable and efficacious ADC. This novel disulfide ADC was compared to a conjugate containing the same PBD drug, but attached to the antibody via a peptide linker...
February 21, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28221241/hyperpolarized-helium-3-diffusion-weighted-magnetic-resonance-imaging-detects-abnormalities-of-lung-structure-in-children-with-bronchopulmonary-dysplasia
#16
Lucia Flors, John P Mugler, Alix Paget-Brown, Deborah K Froh, Eduard E de Lange, James T Patrie, Talissa A Altes
PURPOSE: The aim of the study was to determine whether hyperpolarized He diffusion-weighted magnetic resonance imaging detects abnormalities in the lungs in children with bronchopulmonary dysplasia (BPD) as compared with age-matched normal children. MATERIALS AND METHODS: All experiments were compliant with Health Insurance Portability and Accountability Act (HIPAA) and performed with Food and Drug Administration approval under an IND application. The protocol was approved by our Institutional Review Board, and written informed consent was obtained...
February 17, 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28220831/the-distribution-of-the-apparent-diffusion-coefficient-as-an-indicator-of-the-response-to-chemotherapeutics-in-ovarian-tumour-xenografts
#17
Monique C Tourell, Ali Shokoohmand, Marietta Landgraf, Nina P Holzapfel, Patrina S P Poh, Daniela Loessner, Konstantin I Momot
Diffusion-weighted magnetic resonance imaging (DW-MRI) was used to evaluate the effects of single-agent and combination treatment regimens in a spheroid-based animal model of ovarian cancer. Ovarian tumour xenografts grown in non-obese diabetic/severe-combined-immunodeficiency (NOD/SCID) mice were treated with carboplatin or paclitaxel, or combination carboplatin/paclitaxel chemotherapy regimens. After 4 weeks of treatment, tumours were extracted and underwent DW-MRI, mechanical testing, immunohistochemical and gene expression analyses...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28216573/a-conjugate-based-on-anti-her2-diaffibody-and-auristatin-e-targets-her2-positive-cancer-cells
#18
Anna M Serwotka-Suszczak, Alicja M Sochaj-Gregorczyk, Jerzy Pieczykolan, Daniel Krowarsch, Filip Jelen, Jacek Otlewski
Antibody-drug conjugates (ADCs) have recently emerged as efficient and selective cancer treatment therapeutics. Currently, alternative forms of drug carriers that can replace monoclonal antibodies are under intensive investigation. Here, a cytotoxic conjugate of an anti-HER2 (Human Epidermal Growth Factor Receptor 2) diaffibody with monomethyl-auristatin E (MMAE) is proposed as a potential anticancer therapeutic. The anti-HER2 diaffibody was based on the ZHER2:4 affibody amino acid sequence. The anti-HER2 diaffibody has been expressed as a His-tagged protein in E...
February 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28216452/water-and-lipid-diffusion-mri-using-chemical-shift-displacement-based-separation-of-lipid-tissue-split
#19
Naoki Ohno, Hirohito Kan, Tosiaki Miyati, Toshitaka Aoki, Shota Ishida, Toshifumi Gabata
PURPOSE: To obtain water and lipid diffusion-weighted images (DWIs) simultaneously, we devised a novel method utilizing chemical shift displacement-based separation of lipid tissue (SPLIT) imaging. MATERIALS AND METHODS: Single-shot diffusion echo-planar imaging without fat suppression was used and the imaging parameters were optimized to separate water and lipid DWIs by chemical shift displacement of the lipid signals along the phase-encoding direction. Using the optimized conditions, transverse DWIs at the maximum diameter of the right calf were scanned with multiple b-values in five healthy subjects...
February 16, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28216140/expression-profiles-of-cancer-stem-cell-markers-cd133-cd44-musashi-1-and-epcam-in-the-cardiac-mucosa-barrett-s-esophagus-early-esophageal-adenocarcinoma-advanced-esophageal-adenocarcinoma-sequence
#20
Anna Mokrowiecka, Lothar Veits, Christina Falkeis, Jacek Musial, Radzislaw Kordek, Mariusz Lochowski, Jozef Kozak, Agnieszka Wierzchniewska-Lawska, Michael Vieth, Ewa Malecka-Panas
INTRODUCTION: Barrett's esophagus (BE), which develops as a result of gastroesophageal reflux disease, is a preneoplastic condition for esophageal adenocarcinoma (EAC). A new hypothesis suggests that cancer is a disease of stem cells, however, their expression and pathways in BE - EAC sequence are not fully elucidated yet. AIMS: We used a panel of putative cancer stem cells markers to identify stem cells in consecutive steps of BE-related cancer progression. METHODS: Immunohistochemistry was performed on formalin-fixed, paraffin-embedded blocks from 58 patients with normal cardiac mucosa (n=5), BE (n=14), early EAC (pT1) from mucosal resection (n=17) and advanced EAC (pT1-T4) from postoperative specimens (n=22)...
December 30, 2016: Pathology, Research and Practice
keyword
keyword
45670
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"