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https://www.readbyqxmd.com/read/29785725/density-scaling-of-phantom-materials-for-a-3d-dose-verification-system
#1
Kensuke Tani, Yukio Fujita, Akihisa Wakita, Ryohei Miyasaka, Ryuzo Uehara, Takumi Kodama, Yuya Suzuki, Ako Aikawa, Norifumi Mizuno, Jiro Kawamori, Hidetoshi Saitoh
In this study, the optimum density scaling factors of phantom materials for a commercially available three-dimensional (3D) dose verification system (Delta4) were investigated in order to improve the accuracy of the calculated dose distributions in the phantom materials. At field sizes of 10 × 10 and 5 × 5 cm2 with the same geometry, tissue-phantom ratios (TPRs) in water, polymethyl methacrylate (PMMA), and Plastic Water Diagnostic Therapy (PWDT) were measured, and TPRs in various density scaling factors of water were calculated by Monte Carlo simulation, Adaptive Convolve (AdC, Pinnacle3 ), Collapsed Cone Convolution (CCC, RayStation), and AcurosXB (AXB, Eclipse)...
May 21, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29785469/early-detection-of-cerebral-infarction-after-focal-ischemia-using-a-new-mri-indicator
#2
Yukako Nakajo, Qiang Zhao, Jun-Ichiro Enmi, Hidehiro Iida, Jun C Takahashi, Hiroharu Kataoka, Keiko Yamato, Hiroji Yanamoto
Prolongation of the T2 relaxation time, an increase in T2-weighted signal intensity (T2-SI), and a decrease in the apparent diffusion coefficient (ADC) calculated from diffusion-weighted images (DWI) on magnetic resonance imaging (MRI) are conventional indicators of the vasogenic (interstitial) or cytotoxic (cellular) cerebral edema that develops after ischemic stroke. However, these parameters obtained on stroke imaging have not given us a precise threshold at which we can determine the viability or vulnerability of the tissue, allowing us to decide on an intervention that will help reversible tissue in the acute phase...
May 21, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29782920/whole-lesion-histogram-analysis-of-meningiomas-derived-from-adc-values-correlation-with-several-cellularity-parameters-proliferation-index-ki-67-nucleic-content-and-membrane-permeability
#3
Alexey Surov, Gordian Hamerla, Hans Jonas Meyer, Karsten Winter, Stefan Schob, Eckhard Fiedler
PURPOSE: To analyze several histopathological features and their possible correlations with whole lesion histogram analysis derived from ADC maps in meningioma. MATERIALS AND METHODS: The retrospective study involved 36 patients with primary meningiomas. For every tumor, the following histogram analysis parameters of apparent diffusion coefficient (ADC) were calculated: ADCmean , ADCmax , ADCmin , ADCmedian , ADCmode , ADC percentiles: P10, P25, P75, P90, as well kurtosis, skewness, and entropy...
May 18, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29781342/dw-mri-and-dce-mri-are-of-complementary-value-in-predicting-pathologic-response-to-neoadjuvant-chemoradiotherapy-for-esophageal-cancer
#4
Sophie E Heethuis, Lucas Goense, Peter S N van Rossum, Alicia S Borggreve, Stella Mook, Francine E M Voncken, Annemarieke Bartels-Rutten, Berthe M P Aleman, Richard van Hillegersberg, Jelle P Ruurda, Gert J Meijer, Jan J W Lagendijk, Astrid L H M W van Lier
PURPOSE: To explore the potential benefit and complementary value of a multiparametric approach using diffusion-weighted (DW-) and dynamic contrast-enhanced (DCE-) magnetic resonance imaging (MRI) for prediction of response to neoadjuvant chemoradiotherapy (nCRT) in esophageal cancer. MATERIAL AND METHODS: Forty-five patients underwent both DW-MRI and DCE-MRI prior to nCRT (pre), during nCRT (week 2-3) (per) and after completion of nCRT, but prior to esophagectomy (post)...
May 21, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29779158/diffusion-weighted-magnetic-resonance-enterography-for-prediction-of-response-to-tumor-necrosis-factor-inhibitors-in-stricturing-crohn-s-disease
#5
Marianne M Amitai, Eyal Klang, Asaf Levartovsky, Noa Rozendorn, Shelly Soffer, Gadeer Ali Taha, Bella Ungar, Tomer Greener, Shomron Ben-Horin, Rami Eliakim, Uri Kopylov
BACKGROUND AND AIMS: Distinguishing between fibrotic and inflammatory strictures in Crohn's disease (CD) is still challenging. The capacity of diffusion-weighted (DWI) magnetic resonance (MRE) to identify intestinal fibrosis was recently demonstrated; however, the therapeutic implications of this association have never been evaluated. The aim of the current study was to identify imaging features, including DWI, which can predict response to anti-inflammatory treatment in patients with stricturing CD...
May 19, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29778691/alterations-in-apparent-diffusion-coefficient-values-of-the-kidney-during-the-cardiac-cycle-evaluation-with-ecg-triggered-diffusion-weighted-mr-imaging
#6
Katsuyoshi Ito, Minoru Hayashida, Akihiko Kanki, Akira Yamamoto, Tsutomu Tamada, Koji Yoshida, Masahiro Tanabe
PURPOSE: To evaluate dynamic changes in apparent diffusion coefficient (ADC) values of the kidney at different time points during the cardiac cycle using electrocardiographic (ECG)-triggered diffusion-weighted MR imaging in normal subjects, and to elucidate the differences in ADC values between the right and left kidneys during a cardiac cycle. MATERIALS AND METHODS: The study was approved by our institutional review board and informed consent was obtained from subjects...
May 17, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29776704/cerebellar-peduncle-injury-predicts-motor-impairments-in-preterm-infants-a-quantitative-tractography-study-at-term-equivalent-age
#7
Tatsuji Hasegawa, Kei Yamada, Takenori Tozawa, Tomohiro Chiyonobu, Sachiko Tokuda, Akira Nishimura, Hajime Hosoi, Masafumi Morimoto
PURPOSE: Cerebellar injury is well established as an important finding in preterm infants with cerebral palsy (CP). In this study, we investigated associations between injury to the cerebellar peduncles and motor impairments in preterm infants using quantitative tractography at term-equivalent age, which represents an early phase before the onset of motor impairments. METHODS: We studied 64 preterm infants who were born at <33 weeks gestational age. These infants were divided into three groups: CP, Non-CP (defined as infants with periventricular leukomalacia but having normal motor function), and a Normal group...
May 15, 2018: Brain & Development
https://www.readbyqxmd.com/read/29774894/value-of-diffusion-weighted-imaging-for-monitoring-tissue-change-during-magnetic-resonance-guided-high-intensity-focused-ultrasound-therapy-in-bone-applications-an-ex-vivo-study
#8
Sharon L Giles, Jessica M Winfield, David J Collins, Ian Rivens, John Civale, Gail R Ter Haar, Nandita M deSouza
Background: Magnetic resonance (MR)-guided high-intensity focused ultrasound (HIFU) can palliate metastatic bone pain by periosteal neurolysis. We investigated the value of diffusion-weighted imaging (DWI) for monitoring soft tissue changes adjacent to bone during MR-guided HIFU. We evaluated the repeatability of the apparent diffusion coefficient (ADC) measurement, the temporal evolution of ADC change after sonication, and its relationship with thermal parameters. Methods: Ex-vivo experiments in lamb legs ( n = 8) were performed on a Sonalleve MR-guided HIFU system...
2018: European radiology experimental
https://www.readbyqxmd.com/read/29774316/dual-phase-adc-modelling-of-breast-masses-in-diffusion-weighted-imaging-comparison-with-histopathologic-findings
#9
Gökhan Ertaş, Can Onaygil, Onur Buğdaycı, Erkin Arıbal
Objective: To investigate the diagnostic value of dual-phase apparent diffusion coefficient (ADC) compared to traditional ADC values in quantitative diffusion-weighted imaging (DWI) for differentiating between benign and malignant breast masses. Materials and Methods: Diffusion-weighted images of pathologically confirmed 88 benign and 85 malignant lesions acquired using a 3.0T MR scanner were analyzed. Small region-of-interests focusing on the highest signal intensity of lesions were used...
April 2018: European Journal of Breast Health
https://www.readbyqxmd.com/read/29774180/survival-prediction-based-on-qualitative-mri-diffusion-signature-in-patients-with-recurrent-high-grade-glioma-treated-with-bevacizumab
#10
Pradeep Goyal, Mary Tenenbaum, Sonali Gupta, Puneet S Kochar, Alok A Bhatt, Manisha Mangla, Yogesh Kumar, Rajiv Mangla
Background: Bevacizumab was approved by the FDA for the treatment of recurrent or progressive glioblastoma (GBM). Imaging responses are typically assessed by gadolinium-enhanced MRI. We sought to determine the significance of qualitative diffusion signature (manifest as variable degree of dark signal) on ADC maps in recurrent gliomas after treatment with bevacizumab. Methods: We performed an institutional review board (IRB) approved retrospective study on patients who underwent MRI of the brain after 8 weeks of receiving bevacizumab for recurrent glioma...
April 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29774090/strong-sod2-expression-and-hpv-16-18-positivity-are-independent-events-in-cervical-cancer
#11
Silvia Helena Rabelo-Santos, Lara Termini, Enrique Boccardo, Sophie Derchain, Adhemar Longatto-Filho, Maria Antonieta Andreoli, Maria Cecília Costa, Rafaella Almeida Lima Nunes, Liliana Aparecida Lucci Ângelo-Andrade, Luisa Lina Villa, Luiz Carlos Zeferino
It is well known that persistent infection with high-risk HPV (hr-HPV), mostly HPV-16 and 18, is the main cause of cervical cancer development. Manganese superoxide dismutase (MnSOD or SOD2) are highly expressed in different neoplasia. The present study investigated SOD2 protein expression and the presence of hr-HPV types in 297 cervical samples including non-neoplastic tissue, cervical intraepithelial neoplasia grade 3 (CIN3), squamous cell carcinoma (SCC) and adenocarcinoma (ADC). Strong SOD2 expression was significantly higher in ADC (82%) than CIN3 (52%) or SCC (64%)...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29772253/interstitial-ion-homeostasis-and-acid-base-balance-are-maintained-in-oedematous-brain-of-mice-with-acute-toxic-liver-failure
#12
Marta Obara-Michlewska, Fengfei Ding, Mariusz Popek, Alexei Verkhratsky, Maiken Nedergaard, Magdalena Zielinska, Jan Albrecht
Acute toxic liver failure (ATLF) rapidly leads to brain oedema and neurological decline. We evaluated the ability of ATLF-affected brain to control the ionic composition and acid-base balance of the interstitial fluid. ATLF was induced in 10-12 weeks old male C57Bl mice by single intraperitoneal (i.p.) injection of 100 μg/g azoxymethane (AOM). Analyses were carried out in cerebral cortex of precomatous mice 20-24 h after AOM administration. Brain fluid status was evaluated by measuring apparent diffusion coefficient [ADC] using NMR spectroscopy, Evans Blue extravasation, and accumulation of an intracisternally-injected fluorescent tracer...
May 14, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29771954/preoperative-prediction-of-microvascular-invasion-of-hepatocellular-carcinoma-with-ivim-diffusion-weighted-mr-imaging-and-gd-eob-dtpa-enhanced-mr-imaging
#13
Wei Zhao, Wenguang Liu, Huaping Liu, Xiaoping Yi, Jiale Hou, Yigang Pei, Hui Liu, Deyun Feng, Liyu Liu, Wenzheng Li
Microvascular invasion (MVI) is regarded as one of the independent risk factors for recurrence and poor prognosis of hepatocellular carcinoma (HCC). The presence of MVI in HCCs was evaluated on the basis of pathological reports of surgical specimens and was defined as tumor within a vascular space lined by endothelium that was visible only on microscopy. The aim of the study was to investigate the usefulness of intravoxel incoherent motion (IVIM) diffusion weighted (DW) magnetic resonance (MR) imaging in predicting MVI of HCC...
2018: PloS One
https://www.readbyqxmd.com/read/29770848/imaging-biomarkers-from-multiparametric-magnetic-resonance-imaging-are-associated-with-survival-outcomes-in-patients-with-brain-metastases-from-breast-cancer
#14
Bang-Bin Chen, Yen-Shen Lu, Chih-Wei Yu, Ching-Hung Lin, Tom Wei-Wu Chen, Shwu-Yuan Wei, Ann-Lii Cheng, Tiffany Ting-Fang Shih
OBJECTIVES: The aim of this study is to investigate the correlation of survival outcomes with imaging biomarkers from multiparametric magnetic resonance imaging (MRI) in patients with brain metastases from breast cancer (BMBC). METHODS: This study was approved by the institutional review board. Twenty-two patients with BMBC who underwent treatment involving bevacizumab on day 1, etoposide on days 2-4, and cisplatin on day 2 in 21-day cycles were prospectively enrolled for a phase II study...
May 16, 2018: European Radiology
https://www.readbyqxmd.com/read/29770735/the-diagnostic-value-of-using-combined-mr-diffusion-parameters-to-differentiate-between-low-and-high-grade-meningioma
#15
Kerim Aslan, Hediye Pinar Gunbey, Leman Tomak, Lutfi Incesu
OBJECTIVE: The purpose of this study was to examine whether the combined use of MR diffusion parameters [Diffusion tensor imaging (DTI)-apparent diffusion coefficient (ADC), fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD)] could provide a more accurate diagnosis in differentiating between low-grade and atypical/anaplastic (high-grade) meningioma. METHODS: Pathologically proven 45 meningioma patients [32 low-grade, 13 high-grade (11 atypical and 2 anaplastic)] who had received DTI before surgery were assessed retrospectively by 2 independent observers...
May 17, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29769042/mpcad-a-multi-scale-radiomics-driven-framework-for-automated-prostate-cancer-localization-and-detection
#16
Farzad Khalvati, Junjie Zhang, Audrey G Chung, Mohammad Javad Shafiee, Alexander Wong, Masoom A Haider
BACKGROUND: Quantitative radiomic features provide a plethora of minable data extracted from multi-parametric magnetic resonance imaging (MP-MRI) which can be used for accurate detection and localization of prostate cancer. While most cancer detection algorithms utilize either voxel-based or region-based feature models, the complexity of prostate tumour phenotype in MP-MRI requires a more sophisticated framework to better leverage available data and exploit a priori knowledge in the field...
May 16, 2018: BMC Medical Imaging
https://www.readbyqxmd.com/read/29766172/effect-of-conformational-flexibility-on-photophysics-of-bis-coumarins
#17
Łukasz Kielesiński, Daniel T Gryko, Andrzej L Sobolewski, Olaf W Morawski
The fluorescence intensity of bis-coumarins linked via CONH and COO functionalities are shown to exhibit a strong dependance on solvent polarity. The presence of the intramolecular hydrogen bond between the C[double bond, length as m-dash]O oxygen atom of coumarin and amide-NH moieties reduces the number of thermodynamically populated conformations in both ground and electronically excited states and an anti-arrangement of coumarin units is favored. Additionally, the rigidity of the linker raises the barrier to the conical intersection with the ground state, and in non-polar solvents strong fluorescence is observed...
May 16, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29765230/clinical-and-radiological-characteristics-of-central-pulmonary-adenocarcinoma-a-comparison-with-central-squamous-cell-carcinoma-and-small-cell-lung-cancer-and-the-impact-on-treatment-response
#18
Zhe Wang, Minghuan Li, Yong Huang, Li Ma, Hui Zhu, Li Kong, Jinming Yu
Purpose: The proportion of central pulmonary adenocarcinoma (ADC) in central-type lung cancer has been gradually increasing due to the overall increasing incidence of pulmonary ADC. But the clinical and radiological characteristics of central ADCs remain unclear. In this study, we compared the clinical and radiological characteristics of central ADCs with those of small cell lung cancers (SCLCs) and squamous cell carcinomas (SQCCs) and investigated the impact of these characteristics on patients' treatment response...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29764866/lrrc15-is-a-novel-mesenchymal-protein-and-stromal-target-for-antibody-drug-conjugates
#19
James W Purcell, Sonia G Tanlimco, Jonathan A Hickson, Melvin Fox, Mien Sho, Lisa Durkin, Tamar Uziel, Rick Powers, Kelly D Foster-Duke, Thomas McGonigal, Subashri Kumar, Josue Samayoa, Dong Zhang, Joann P Palma, Sasmita Mishra, Diane Hollenbaugh, Kurt Gish, Susan E Morgan-Lappe, Eric D Hsi, Debra T Chao
Progress in understanding tumor stromal biology has been constrained in part because cancer-associated fibroblasts (CAF) are a heterogeneous population with limited cell type-specific protein markers. Using RNA expression profiling, we identified the membrane protein leucine rich repeat containing 15 (LRRC15) as highly expressed in multiple solid tumor indications with limited normal tissue expression. LRRC15 was expressed on stromal fibroblasts in many solid tumors (e.g., breast, head and neck, lung, pancreatic) as well as directly on a subset of cancer cells of mesenchymal origin (e...
May 15, 2018: Cancer Research
https://www.readbyqxmd.com/read/29764854/preclinical-antitumor-activity-of-a-novel-anti-c-kit-antibody-drug-conjugate-against-mutant-and-wild-type-c-kit-positive-solid-tumors
#20
Tinya J Abrams, Anu Connor, Christie P Fanton, Steven B Cohen, Thomas Huber, Kathy Miller, E Erica Hong, Xiaohong Niu, Janine Kline, Marjorie Ison-Dugenny, Sarah Harris, Dana B Walker, Klaus R Krauser, Francesco Galimi, Zhen Wang, Majid Ghoddusi, Keith G Mansfield, Si Tuen Lee-Hoeflich, Jocelyn Holash, Nancy Pryer, William Kluwe, Seth A Ettenberg, William R Sellers, Emma Lees, Paul Kwon, Judith A Abraham, Siew Schleyer
PURPOSE: c-KIT overexpression is well-recognized in cancers such as GIST, SCLC, melanoma, NSCLC and AML. Treatment with the small molecule inhibitors imatinib, sunitinib and regorafenib result in resistance (c-KIT mutant tumors) or limited activity (c-KIT wildtype tumors). We selected an anti-c-KIT ADC approach to evaluate the anti-cancer activity in multiple disease models. EXPERIMENTAL DESIGN: A humanized anti-c-KIT antibody LMJ729 was conjugated to the microtubule destabilizing maytansinoid, DM1, via a non-cleavable linker (SMCC)...
May 15, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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