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https://www.readbyqxmd.com/read/29332248/performance-of-diffusion-weighted-magnetic-resonance-imaging-at-3-0t-for-early-assessment-of-tumor-response-in-locally-advanced-rectal-cancer-treated-with-preoperative-chemoradiation-therapy
#1
Andrea Delli Pizzi, Roberta Cianci, Domenico Genovesi, Gianluigi Esposito, Mauro Timpani, Alessandra Tavoletta, Pierluigi Pulsone, Raffaella Basilico, Daniela Gabrielli, Consuelo Rosa, Luciana Caravatta, Monica Di Tommaso, Massimo Caulo, Antonella Filippone
PURPOSE: The purpose of the article is to determine whether changes in apparent diffusion coefficient (ADC) values of locally advanced rectal cancer (LARC) obtained 2 weeks after the beginning of chemoradiation therapy (CRT) allow to predict treatment response and whether correlate with tumor histopathologic response. METHODS: Forty-three patients receiving CRT for LARC and 3.0T magnetic resonance imaging with diffusion-weighted sequences before treatment, 2 weeks during, and 8 weeks post the completion of CRT were included...
January 13, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29332045/the-uniform-data-set-czech-version-normative-data-in-older-adults-from-an-international-perspective
#2
Tomas Nikolai, Hana Stepankova, Miloslav Kopecek, Zdenek Sulc, Martin Vyhnalek, Ondrej Bezdicek
BACKGROUND: Outside of the United States, international perspectives on normative data for neuropsychological test performance, within diverse populations, have been scarce. The neuropsychological test battery from the Uniform Data Set (UDS) of the Alzheimer's Disease Centers (ADC) program of the United States National Institute on Aging (NIA) is one of the most sensitive batteries for the evaluation of both normal cognitive aging and pathological cognitive decline. OBJECTIVE: This study aimed to determine the feasibility of the Czech Neuropsychological Test Battery from the Uniform Data Set (UDS-Cz 2...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29332032/value-of-conventional-mri-and-diffusion-tensor-imaging-parameters-in-predicting-surgical-outcome-in-patients-with-degenerative-cervical-myelopathy
#3
Canghai Shen, Haiwei Xu, Baoshan Xu, Xiaoguang Zhang, Xiaofeng Li, Qiang Yang, Xinlong Ma
BACKGROUND: In addition to conventional magnetic resonance imaging (cMRI), diffusion tensor imaging (DTI) has been investigated as a potential diagnostic and prognostic tool for patients with degenerative cervical myelopathy (DCM). OBJECTIVE: To assess the efficacy of cMRI and DTI parameters in prediction of surgical outcome in DCM patients. METHODS: One hundred and forty-two patients with DCM who underwent presurgical cMRI and DTI of the cervical spine were included...
December 29, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/29331362/multi-model-analysis-of-diffusion-weighted-imaging-of-normal-testes-at-3-0-t-preliminary-findings
#4
Xiangde Min, Zhaoyan Feng, Liang Wang, Jie Cai, Basen Li, Zan Ke, Peipei Zhang, Huijuan You, Xu Yan
RATIONALE AND OBJECTIVES: This study aimed to establish diffusion quantitative parameters (apparent diffusion coefficient [ADC], DDC, α, Dapp, and Kapp) in normal testes at 3.0 T. MATERIALS AND METHODS: Sixty-four healthy volunteers in two age groups (A: 10-39 years; B: ≥ 40 years) underwent diffusion-weighted imaging scanning at 3.0 T. ADC1000, ADC2000, ADC3000, DDC, α, Dapp, and Kapp were calculated using the mono-exponential, stretched-exponential, and kurtosis models...
January 10, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29330631/apparent-diffusion-coefficient-mapping-using-diffusion-weighted-mri-impact-of-background-parenchymal-enhancement-amount-of-fibroglandular-tissue-and-menopausal-status-on-breast-cancer-diagnosis
#5
Joao V Horvat, Manuela Durando, Soledad Milans, Sujata Patil, Jessica Massler, Girard Gibbons, Dilip Giri, Katja Pinker, Elizabeth A Morris, Sunitha B Thakur
OBJECTIVES: To investigate the impact of background parenchymal enhancement (BPE), amount of fibroglandular tissue (FGT) and menopausal status on apparent diffusion coefficient (ADC) values in differentiation between malignant and benign lesions. METHODS: In this HIPAA-compliant study, mean ADC values of 218 malignant and 130 benign lesions from 288 patients were retrospectively evaluated. The differences in mean ADC values between benign and malignant lesions were calculated within groups stratified by BPE level (high/low), amount of FGT (dense/non-dense) and menopausal status (premenopausal/postmenopausal)...
January 12, 2018: European Radiology
https://www.readbyqxmd.com/read/29329735/diagnostic-value-of-early-postoperative-mri-and-diffusion-weighted-imaging-following-trans-sphenoidal-resection-of-non-functioning-pituitary-macroadenomas
#6
H A Hassan, M A Bessar, I R Herzallah, A M Laury, M M Arnaout, M A A Basha
AIM: To establish the value of early contrast-enhanced magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) in differentiating residual pituitary adenoma from postoperative surgical changes. MATERIALS AND METHODS: Thirty patients with non-functioning pituitary macroadenomas, who were undergoing trans-sphenoidal adenomectomy, were prospectively studied. Patients were imaged with both MRI and DWI in the early postoperative period, as well as 6-months post-surgery...
January 9, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29325414/molecular-dynamics-of-photoinduced-reactions-of-acrylic-acid-products-mechanisms-and-comparison-with-experiment
#7
Dorit Shemesh, Robert Benny Gerber
The photochemistry of acrylic acid is of considerable atmospheric importance. However, the mechanisms and the timescales of the reactions involved are unknown. In this work, the products, yields and reaction pathways of acrylic acid photochemistry are investigated theoretically by molecular dynamics simulations on the ππ* excited state. Two methods were used to describe the excited state: the semi-empirical OM2/MRCI and the ab initio ADC(2). Over one hundred trajectories were computed with each method. A rich variety of reaction channels including mechanisms, timescales and yields, are predicted for the single potential energy surface used...
January 11, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29322269/prognostic-value-of-simultaneous-18f-fdg-pet-mri-using-a-combination-of-metabolo-volumetric-parameters-and-apparent-diffusion-coefficient-in-treated-head-and-neck-cancer
#8
Yong-Il Kim, Gi Jeong Cheon, Seo Young Kang, Jin Chul Paeng, Keon Wook Kang, Dong Soo Lee, June-Key Chung
BACKGROUND: The aim of this study was to determine the usefulness of combined positron emission tomography (PET)/magnetic resonance imaging (MRI) parameters provided by simultaneous 18F-fluorodeoxyglucose (FDG) PET/MRI for the prediction of treatment failure in surgically resected head and neck cancer. We hypothesized that PET parameters corrected by tumor cellularity (combined PET/MRI parameters) could predict the prognosis. On regional PET, maximum standardized uptake value (SUVmax) was measured as metabolic parameters...
January 10, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/29322118/mr-imaging-features-of-tubular-carcinoma-preliminary-experience-in-twelve-masses
#9
Ravza Yılmaz, Zuhal Bayramoğlu, Selman Emirikçi, Semen Önder, Artur Salmaslıoğlu, Memduh Dursun, Gülden Acunaş, Vahit Özmen
Objective: We retrospectively analyzed the magnetic resonance (MR) imaging features and diffusion-weighted imaging findings of the 12 masses of 10 patients with tubular carcinoma (TC), including mammography and sonography findings. Materials and Methods: Mammographic, sonographic and magnetic resonance imaging features in 12 histopathologically confirmed masses diagnosed as TC of the breast within 10 patients were evaluated. Morphologic characteristics, enhancement features, apparent diffusion coefficient (ADC) values were reviewed...
January 2018: European Journal of Breast Health
https://www.readbyqxmd.com/read/29321485/role-of-diffusion-weighted-imaging-in-the-discrimination-of-benign-and-metastatic-parotid-area-lymph-nodes-in-patients-with-nasopharyngeal-carcinoma
#10
Chuanben Chen, Zhizhong Lin, Youping Xiao, Penggang Bai, Qiuyuan Yue, Yunbin Chen, Lisha Chen
To assess the utility of apparent diffusion coefficient (ADC) determined on diffusion-weighted MR imaging (DWI) to differentiate between benign and malignant parotid area lymph nodes (PLN) in nasopharyngeal carcinoma (NPC) patients. Thirty-nine consecutive NPC patients with a total of 40 enlarged, biopsied PLNs underwent DWI examination. ADC values for benign and malignant PLNs were measured and compared. Receiver operating characteristic (ROC) curve analysis was to evaluate the optimal threshold level of ADC values for metastatic PLNs...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29319381/novel-use-of-non-echo-planar-diffusion-weighted-mri-in-monitoring-disease-activity-and-treatment-response-in-active-grave-s-orbitopathy-an-initial-observational-cohort-study
#11
Ravi Kumar Lingam, Pravin Mundada, Vickie Lee
AIM: To examine the novel use of non-echo-planar diffusion weighted MRI (DWI) in depicting activity and treatment response in active Grave's orbitopathy (GO) by assessing, with inter-observer agreement, for a correlation between its apparent diffusion coefficients (ADCs) and conventional Short tau Inversion Recovery (STIR) MRI signal-intensity ratios (SIRs). METHOD AND MATERIALS: A total of 23 actively inflamed muscles and 30 muscle response episodes were analysed in patients with active GO who underwent medical treatment...
January 10, 2018: Orbit
https://www.readbyqxmd.com/read/29319167/antibody-drug-conjugates-promising-and-efficient-tools-for-targeted-cancer-therapy
#12
REVIEW
Hadi Nasiri, Zahra Valedkarimi, Leili Aghebati-Maleki, Jafar Majidi
Over the recent decades, the use of antibody-drug conjugates (ADCs) has led to a paradigm shift in cancer chemotherapy. Antibody-based treatment of various human tumors has presented dramatic efficacy and is now one of the most promising strategies used for targeted therapy of patients with a variety of malignancies, including hematological cancers and solid tumors. Monoclonal antibodies (mAbs) are able to selectively deliver cytotoxic drugs to tumor cells, which express specific antigens on their surface, and has been suggested as a novel category of agents for use in the development of anticancer targeted therapies...
January 10, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29318432/the-price-study-the-role-of-conventional-and-diffusion-weighted-magnetic-resonance-imaging-in-assessment-of-locally-advanced-cervical-cancer-patients-administered-by-chemoradiation-followed-by-radical-surgery
#13
A L Valentini, M Miccò, B Gui, M Giuliani, E Rodolfino, A M Telesca, T Pasciuto, A Testa, M A Gambacorta, G Zannoni, V Rufini, A Giordano, V Valentini, G Scambia, R Manfredi
OBJECTIVES: To analyse the role of DW-MRI in early prediction of pathologically-assessed residual disease in locally-advanced cervical cancer (LACC) treated with neoadjuvant chemoradiotherapy followed by radical surgery. METHODS: Between October 2010-June 2014, 108 women with histologically-proven cervical cancer were screened; 88 were included in this study. Tumour volume (TV) and ADCmean were measured before (baseline-MRI) and after 2 weeks of chemoradiotherapy (early-MRI)...
January 9, 2018: European Radiology
https://www.readbyqxmd.com/read/29316337/a-novel-enediyne-integrated-antibody-drug-conjugate-shows-promising-anti-tumor-efficacy-against-cd30-lymphomas
#14
Rong Wang, Liang Li, Shenghua Zhang, Yi Li, Xiaofei Wang, Qingfang Miao, Yongsu Zhen
CD30 is a 120-kDa type I trans-membrane glycoprotein belonging to the tumor necrosis factor (TNF) receptor superfamily. Overexpression of CD30 has been reported in Hodgkin lymphoma (HL) and anaplastic large cell lymphoma (ALCL). CD30-targeted treatment with antibody-drug conjugates (ADCs) can lead to promising clinical benefit. Lidamycin (LDM), consisting of an apoprotein LDP and an active enediyne chromaphore AE, is a member of the enediyne antibiotic family and one of the most potent antitumor agents. AE and LDP can be dissociated and reconstituted under certain conditions in vitro...
January 9, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29315957/apparent-diffusion-coefficients-in-prostate-cancer-correlation-with-molecular-markers-ki-67-hif-1%C3%AE-and-vegf
#15
Teng Ma, Shaolin Yang, Haiyan Jing, Lin Cong, Zhixin Cao, Zhiling Liu, Zhaoqin Huang
Prostate cancer (PCa) is the second most common cancer in men. The Gleason score (GS) and biomarkers play important roles in the diagnosis and treatment of patients with PCa. The purpose of this study was to investigate the relationship between the apparent diffusion coefficient (ADC) and the molecular markers Ki-67, hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in PCa. Thirty-nine patients with 39 lesions, who had been diagnosed with PCa, were enrolled in this study. All patients underwent diffusion-weighted magnetic resonance imaging (DW-MRI) (b = 800 s/mm2 )...
January 9, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29315904/the-effects-of-ageing-on-mouse-muscle-microstructure-a-comparative-study-of-time-dependent-diffusion-mri-and-histological-assessment
#16
Paola Porcari, Matt G Hall, Chris A Clark, Elizabeth Greally, Volker Straub, Andrew M Blamire
The investigation of age-related changes in muscle microstructure between developmental and healthy adult mice may help us to understand the clinical features of early-onset muscle diseases, such as Duchenne muscular dystrophy. We investigated the evolution of mouse hind-limb muscle microstructure using diffusion imaging of in vivo and in vitro samples from both actively growing and mature mice. Mean apparent diffusion coefficients (ADCs) of the gastrocnemius and tibialis anterior muscles were determined as a function of diffusion time (Δ), age (7...
January 9, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29312643/clinicopathological-significance-of-chfr-methylation-in-non-small-cell-lung-cancer-a-systematic-review-and-meta-analysis
#17
Chen Wang, Wenxia Ma, Rong Wei, Xiaoqin Zhang, Ningning Shen, Lifang Shang, Li E, Ying Wang, Lifang Gao, Xin Li, Bin Wang, Yaping Zhang, Aiping Du
Checkpoint with Forkhead-associated and Ring finger domains (CHFR) is a G2/M checkpoint and tumor-suppressor gene. Recent publications showed the correlation of CHFR promoter methylation with clinicopathological significance of non-small cell lung cancer (NSCLC), however, the results remain inconsistent. The aim of this study is to investigate the Clinicopathological significance of CHFR promoter methylation in NSCLC with a meta-analysis. A total of nine studies were included in the meta-analysis that 816 patients were involved...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29311709/gadoterate-meglumine-decreases-adc-values-of-breast-lesions-depending-on-the-b-value-combination
#18
Otso Arponen, Mazen Sudah, Anna Sutela, Mikko Taina, Amro Masarwah, Timo Liimatainen, Ritva Vanninen
To retrospectively evaluated the influence of administration of the gadolinium based intravenous contrast agent (G-CA) on apparent diffusion coefficient (ADC) values in ADC maps generated using multiple b value combinations. A total of 106 women underwent bilateral 3.0 T breast MRI. As an internal validation, diffusion-weighted imaging (b values of 0, 200, 400, 600, 800 s/mm2) was performed before and after the G-CA (gadoterate meglumine (0.2 ml/kg, 3 ml/s)). Whole lesion and fibroglandular tissue (FGT) covering region-of-interests (ROIs) were drawn on the b = 800 s/mm2 images; ROIs were then propagated to multiple retrospectively generated ADC maps...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29311540/diffusion-tensor-imaging-in-diagnosis-of-post-traumatic-syringomyelia-in-spinal-cord-injury-in-rats
#19
Chao Zhang, Kai Chen, Xiuxin Han, Jiayuanyuan Fu, Patricia Douglas, Anna Y Morozova, Maxim A Abakumov, Ilya L Gubsky, Dejin Li, Jin Guo, Xuening Zhang, Guowen Wang, Vladimir P Chekhonin
BACKGROUND Post-traumatic syringomyelia (PTS) is a common disease after spinal cord injury (SCI). The present study was performed to evaluate the advantages of diffusion tensor imaging (DTI) in estimating SCI and prognosing PTS in SCI rats. MATERIAL AND METHODS Forty rats were divided into 3 groups based on the extent of the individual SCI and PTS: a control group (n=10), a PTS group (n=8), and an SCI group (n=22). BBB tests were performed preoperatively and postoperatively at (1 d, 3 d, 5 d, 1 w, 2 w, 1 w, 2 w, 3 w, 4 w, 5 w, and 6 w)...
January 9, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29311298/ikk%C3%AE-inactivation-promotes-kras-initiated-lung-adenocarcinoma-development-through-disrupting-major-redox-regulatory-pathways
#20
Na-Young Song, Feng Zhu, Zining Wang, Jami Willette-Brown, Sichuan Xi, Zhonghe Sun, Ling Su, Xiaolin Wu, Buyong Ma, Ruth Nussinov, Xiaojun Xia, David S Schrump, Peter F Johnson, Michael Karin, Yinling Hu
Lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC) are two distinct and predominant types of human lung cancer. IκB kinase α (IKKα) has been shown to suppress lung SCC development, but its role in ADC is unknown. We found inactivating mutations and homologous or hemizygous deletions in the CHUK. locus, which encodes IKKα, in human lung ADCs. The CHUK. deletions significantly reduced the survival time of patients with lung ADCs harboring KRAS mutations. In mice, lung-specific Ikkα ablation (IkkαΔLu ) induces spontaneous ADCs and promotes KrasG12D-initiated ADC development, accompanied by increased cell proliferation, decreased cell senescence, and reactive oxygen species (ROS) accumulation...
January 8, 2018: Proceedings of the National Academy of Sciences of the United States of America
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