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https://www.readbyqxmd.com/read/29055277/structural-photophysical-and-theoretical-studies-of-imidazole-based-excited-state-intramolecular-proton-transfer-molecules
#1
Sivaraman Somasundaram, Eswaran Kamaraj, Su Jin Hwang, Sanghyuk Park
Imidazole-based excited state intramolecular proton transfer (ESIPT) blue fluorescent molecules, 2-(1-(4-chlorophenyl)-4,5-diphenyl-1H-imidazol-2-yl)phenol (BHPI-Cl) and 2-(1-(4-bromophenyl)-4,5-diphenyl-1H-imidazol-2-yl)phenol (BHPI-Br) were designed and synthesized by Debus-Radziszewski method through a one-pot multicomponent reaction in high yield. The synthesized compounds were fully characterized by (1)H NMR, (13)C NMR, FT-IR, FT-Raman, GC-Mass, and elemental analysis. The molecular structures in single crystal lattice were studied by X-ray crystallographic analysis...
October 14, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29050954/the-trendy-multi-center-randomized-trial-on-hepatocellular-carcinoma-trial-qa-including-automated-treatment-planning-and-benchmark-case-results
#2
Steven J M Habraken, Abdul Wahab M Sharfo, Jeroen Buijsen, Wilko F A R Verbakel, Cornelis J A Haasbeek, Michel C Öllers, Henrike Westerveld, Niek van Wieringen, Onne Reerink, Enrica Seravalli, Pètra M Braam, Markus Wendling, Thomas Lacornerie, Xavier Mirabel, Reinhilde Weytjens, Lieselotte Depuydt, Stephanie Tanadini-Lang, Oliver Riesterer, Karin Haustermans, Tom Depuydt, Roy S Dwarkasing, François E J A Willemsen, Ben J M Heijmen, Alejandra Méndez Romero
BACKGROUND AND PURPOSE: The TRENDY trial is an international multi-center phase-II study, randomizing hepatocellular carcinoma (HCC) patients between transarterial chemoembolization (TACE) and stereotactic body radiation therapy (SBRT) with a target dose of 48-54 Gy in six fractions. The radiotherapy quality assurance (QA) program, including prospective plan feedback based on automated treatment planning, is described and results are reported. MATERIALS AND METHODS: Scans of a single patient were used as a benchmark case...
October 16, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29050612/preparation-and-characterization-of-amorphous-granular-potato-starches-agps-and-cross-linked-amorphous-granular-potato-starches-clagps
#3
Hui-Yun Kim, Seon-Min Oh, Ji-Eun Bae, Jin-Hwa Yeom, Byung-Yong Kim, Hyun-Seok Kim, Moo-Yeol Baik
Amorphous granular potato starch (AGPS) was prepared through heat treatment of native potato starch (NPS) at 94°C with 53% EtOH, while cross-linked amorphous granular potato starch (CLAGPS) was prepared through cross-linking of NPS with sodium trimetaphosphate/sodium tripolyphosphate (STMP/STPP, 99:1) and heat treatment. Light and polarized microscopy showed that both AGPS and CLAGPS maintained their granule shapes but lost birefringence. DSC and XRD of both AGPS and CLAGPS also revealed complete gelatinization...
December 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29050592/eco-friendly-films-prepared-from-plantain-flour-pcl-blends-under-reactive-extrusion-conditions-using-zirconium-octanoate-as-a-catalyst
#4
Tomy J Gutiérrez, Vera A Alvarez
Plantain flour (Musa ssp., group AAB, sub-group clone Harton)/poly(ε-caprolactone) (PCL) blends, containing glycerol as a plasticizer, were prepared by reactive extrusion (REx) in a twin-screw extruder using zirconium octanoate (Zr(Oct)4) as a catalyst, followed by thermo-compression molding for film development. The films were then characterized in terms of their: infrared (FTIR) spectra, water solubility, thermogravimetric (TGA) curves, differential scanning calorimetry (DSC) thermograms, and X-ray diffraction (XDR) diffractograms, as well as their microstructural, mechanical and antimicrobial properties in order to (1) compare the effects of PCLs with two different molecular weights (Mw) on the characteristics of the plantain flour/PCL blends, and (2) determine whether using Zr(Oct)4 in the production of active composite polymer materials improves their properties...
December 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29048082/high-temperature-ferroelectric-behaviour-in-%C3%AE-mno2-nanorods-realised-through-enriched-oxygen-vacancy-induced-non-stoichiometry
#5
Reenu Elizabeth John, Anoop Chandran, Justin George, Ajai Jose, Gijo Jose, Joshy Jose, N V Unnikrishnan, Marykutty Thomas, K C George
Nanostructuring followed by incorporation of defect induced non-stoichiometry is an emerging field of prominence due to its capacity to introduce unprecedented properties in materials with potential applications. In this work, crystalline α-MnO2 nanorods are synthesised using a facile co-precipitation method to exhibit ferroelectric behaviour for the first time. The evolution mechanism of the nanorods is investigated using XRD, HRTEM and FTIR spectra, while their thermal stability is probed using TGA/DTA. The novel properties observed are the result of structural rearrangements sparked by electrons in mixed valence cations (Mn(3+)/Mn(4+))...
October 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29047017/effect-of-arginine-on-the-aggregation-of-protein-in-freeze-dried-formulations-containing-sugars-and-polyol-1-formulation-development
#6
Ellen Hackl, Joseph Darkwah, Geoff Smith, Irina Ermolina
L-arginine was introduced into protein-based freeze-dried formulations to study the ability of arginine to reduce/prevent from protein aggregation during manufacturing, storage and reconstitution of lyophilized protein-based pharmaceuticals. As L-arginine is known to be very hygroscopic, additional excipients which could provide a moisture buffering capacity need to be introduced into the formulation. In the first part of our study-excipient formulation development-the screening of a number of sugars/polyols has been done in order to select the best combination of excipients that, in a complex with L-arginine, can (i) produce freeze-dried cakes with elegant appearance, adequate mechanical properties and reconstitution times, and (ii) resist/minimise the moisture sorption...
October 18, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29046850/preparation-and-characterization-of-polycarbonate-multiwalled-carbon-nanotube-nanocomposites
#7
Claudio Larosa, Niranjan Patra, Marco Salerno, Lara Mikac, Remo Merijs Meri, Mile Ivanda
A polymer nanocomposite was produced by ultrasonic-assisted dispersion of multiwalled carbon nanotubes (MWCNTs) in a polycarbonate matrix using p-xylene and dichloromethane as the solvents. The filler loading was varied from 1 to 3 wt % in order to examine the effect of MWCNTs on the structure and properties of the composites. The nanocomposites were characterized by DSC, DTA, TGA, UV-vis, FTIR and Raman spectroscopy to evaluate the changes induced by the filler in the polymer matrix. UV-vis, FTIR and Raman spectroscopy measurements confirmed the presence of the dispersed phase in the composite films, while TGA and DSC analysis of the nanocomposites revealed enhanced thermal stability and decreased crystallinity, respectively, as compared to the neat polymer...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/29046825/physicochemical-and-surface-properties-of-acrylic-intraocular-lenses-and-their-clinical-significance
#8
Gyeong Bok Jung, Kyung-Hyun Jin, Hun-Kuk Park
To analyze and compare several commercially available acrylic intraocular lenses (IOLs) with particular regard to their clinical significance, we examined the physicochemical and surface properties of four currently available acrylic IOLs using static water contact angle, atomic force microscopy (AFM), Raman spectroscopy, and differential scanning calorimetry (DSC) measurements. The hydrophobic acrylic IOLs, ZA9003, and MA60BM, had contact angles ranging from 77.9° ± 0.65° to 84.4° ± 0.09°. The contact angles in the hydrophilic acrylic (970C) and heparin-surface-modified (HSM) hydrophilic acrylic IOLs (BioVue) were 61...
2017: Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/29043510/taurine-as-a-water-structure-breaker-and-protein-stabilizer
#9
P Bruździak, A Panuszko, E Kaczkowska, B Piotrowski, A Daghir, S Demkowicz, J Stangret
The enhancing effect on the water structure has been confirmed for most of the osmolytes exhibiting both stabilizing and destabilizing properties in regard to proteins. The presented work concerns osmolytes, which should be classified as "structure breaking" solutes: taurine and N,N,N-trimethyltaurine (TMT). Here, we combine FTIR spectroscopy, DSC calorimetry and DFT calculations to gain an insight into the interactions between osmolytes and two proteins: lysozyme and ubiquitin. Despite high structural similarity, both osmolytes exert different influence on protein stability: taurine is a stabilizer, TMT is a denaturant...
October 17, 2017: Amino Acids
https://www.readbyqxmd.com/read/29040935/thermal-stability-study-of-crystalline-and-novel-spray-dried-amorphous-nilotinib-hydrochloride
#10
Maikel Herbrink, Herman Vromans, Jan Schellens, Jos Beijnen, Bastiaan Nuijen
The thermal characteristics and the thermal degradation of crystalline and amorphous nilotinib hydrochloride (NH) were studied. The spray drying technique was successfully utilized for the amorphization of NH and was evaluated by spectroscopic techniques and differential scanning calorimetry (DSC). The ethanolic spray drying process yielded amorphous NH with a glass transition temperature (Tg) of 147°C. Thermal characterization of the amorphous phase was performed by heat capacity measurements using modulated DSC (mDSC)...
October 12, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29040847/characterization-of-ionic-liquid-pretreated-plant-cell-wall-for-improved-enzymatic-digestibility
#11
Tirath Raj, Ruchi Gaur, Bhawna Yadav Lamba, Nitu Singh, Ravi P Gupta, Ravindra Kumar, Suresh K Puri, S S V Ramakumar
An insight into the properties of cell wall of mustard stalk (MS) pretreated by five ionic liquids (ILs) revealed ILs interaction with cellulose, hemicellulose and lignin components. Differential Scanning Calorimetry (DSC) showed increased pore size coupled with increased population of pores evoked by certain ILs in better facilitating enzymatic accessibility. Interestingly, all the five ILs predominantly increased the propensity of two pore sizes formation; 19 and 198 nm, but remarkable difference in the pore volumes of pretreated MS suggested the supremacy of [OAc](-) based ILs, resulting in higher glucose yields...
October 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29039950/calorimetric-and-spectroscopic-studies-of-the-effects-of-the-cell-penetrating-peptide-pep-1-and-the-antimicrobial-peptide-combi-2-on-vesicles-of-mimicking-escherichia-coli-membrane
#12
Nsoki Phambu, Bashiyar Almarwani, Amjad Alwadai, Esther Nzuzi Phambu, Natalie Faciane, Carmel Marion, Anderson Sunda-Meya
The objective of this study is to measure and compare the effects of the cell penetrating peptide (CPP) Pep-1 and the antimicrobial peptide (AMP) combi-2 on vesicles of membranes mimicking Escherichia coli (E. coli). To characterize the effects of Pep-1 and combi-2 on E. coli membrane vesicles, a combination of five biophysical techniques was employed: fluorescence, infrared, scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC) techniques. Upon addition of E...
October 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29039747/development-of-useful-biomaterial-for-bone-tissue-engineering-by-incorporating-nano-copper-zinc-alloy-ncuzn-in-chitosan-gelatin-nano-hydroxyapatite-ch-g-nhap-scaffold
#13
Juan Carlos Forero, Eduardo Roa, Juan G Reyes, Cristian Acevedo, Nelson Osses
Ceramic and metallic nanoparticles can improve the mechanical and biological properties of polymeric scaffolds for bone tissue engineering (BTE). In this work, nanohydroxyapatite (nHAp) and nano-copper-zinc alloy (nCuZn) were added to a chitosan/gelatin (Ch/G) scaffold in order to investigate the effects on morphological, physical, and biocompatibility properties. Scaffolds were fabricated by a freeze-drying technique using different pre-freezing temperatures. Microstructure and morphology were studied by scanning electron microscopy (SEM), glass transition (Tg) was studied using differential scanning calorimetry (DSC), cell growth was estimated by MTT assay, and biocompatibility was examined in vitro and in vivo by histochemistry analyses...
October 17, 2017: Materials
https://www.readbyqxmd.com/read/29037874/preparation-and-optimization-of-chitosan-gelatin-films-for-sustained-delivery-of-lupeol-for-wound-healing
#14
Satish Patel, Shikha Srivastava, Manju Rawat Singh, Deependra Singh
Lupeol entrapped chitosan-gelatin hydrogel (LCGH) films were prepared by solution cast method by blending chitosan and gelatin solution using glycerol as plasticizer, followed by crosslinking with glutaraldehyde. LCGH films were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), equilibrium water content (EWC), Water vapor transmission rate (WVTR) and in vitro release studies. SEM confirmed presence of the uniform porous network of both blank and LCGH films...
October 13, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29036882/biomineralization-of-fucoidan-peptide-blends-and-their-potential-applications-in-bone-tissue-regeneration
#15
Harrison T Pajovich, Ipsita A Banerjee
Fucoidan (Fuc), a natural polysaccharide derived from brown seaweed algae, and gelatin (Gel) were conjugated to form a template for preparation of biomimetic scaffolds for potential applications in bone tissue regeneration. To the Fuc-Gel we then incorporated the peptide sequence MTNYDEAAMAIASLN (MTN) derived from the E-F hand domain, known for its calcium binding properties. To mimic the components of the extracellular matrix of bone tissue, the Fuc-Gel-MTN assemblies were incubated in simulated body fluid (SBF) to induce biomineralization, resulting in the formation of β-tricalcium phosphate, and hydroxyapatite (HAp)...
September 20, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29036735/facile-synthesis-and-characterization-of-l-aspartic-acid-coated-iron-oxide-magnetic-nanoparticles-ionps-for-biomedical-applications
#16
Marziyeh Salehiabar, Hamed Nosrati, Soodabeh Davaran, Hossein Danafar, Hamidreza Kheiri Manjili
Natural L-aspartic acid coated iron oxide magnetic nanoparticles (Asp@IONPs) were prepared by a one pot, in-situ and green co-precipitation method in an aqueous medium. Functionalized iron oxide magnetic nanoparticles (IONPs) were characterized by Vibrating Sample Magnetometer (VSM), X-ray diffraction (XRD), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM) and Transmission electron microscopy (TEM) techniques. Cellular toxicity of IONPs was also investigated on HEK-293 cell lines...
October 16, 2017: Drug Research
https://www.readbyqxmd.com/read/29035313/microstructural-modification-and-characterization-of-sericite
#17
Yu Liang, Hao Ding, Sijia Sun, Ying Chen
Activated sericite was prepared by thermal modification, acid activation and sodium modification, and it was characterized by X-ray diffraction (XRD) analysis, differential scanning calorimetry (DSC), N₂ adsorption test, thermo-gravimetric analysis (TGA), nuclear magnetic resonance (NMR), and scanning electron microscope (SEM). The results indicated that the crystallinity of raw sericite decreased after thermal modification; the pores with sizes between 5 nm to 10 nm of thermal-modified sericite have collapsed and the surface area increased after thermal modification...
October 16, 2017: Materials
https://www.readbyqxmd.com/read/29031953/stable-and-fast-dissolving-amorphous-drug-composites-preparation-via-impregnation-of-neusilin-%C3%A2-ufl2
#18
Mohammad Azad, Jacqueline Moreno, Rajesh Davé
A promising approach to increase the aqueous solubility, hence the bioavailability, of poorly water-soluble drugs is to convert them into their amorphous state through impregnation into mesoporous silica. Unfortunately, mesoporous silica is not yet available in bulk quantities due to high manufacturing costs. In this work, feasibility of using a commercially available cost-effective mesoporous fine grade Neusilin(®) UFL2 to prepare amorphous drug composites of two model poorly soluble drugs, Fenofibrate and Itraconazole, is established...
October 12, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29030184/screening-of-drug-sericin-solid-dispersions-for-improved-solubility-and-dissolution
#19
Nitin H Salunkhe, Namdeo R Jadhav, Harinath N More, Adhikrao D Jadhav
The aim of present attempt deals with preparation of binary dispersion of sericin, waste of sericulture industry in order to enhance solubility and dissolution of poorly soluble drugs. Solid dispersions (SDs) of BCS-II drugs were prepared by spray drying, solvent evaporation, ball milling and physical mixing in ratio of drug:sericin (1:0.5, 1:1, 1:1.5, 1:2, 1:2.5 and 1:3). Further, SDs were investigated by solubility, ATR-FTIR, XRD, DSC, micromeritics and tablettability, surface morphology and in-vitro dissolution...
October 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29030181/use-of-gelatin-and-gum-arabic-for-encapsulation-of-black-raspberry-anthocyanins-by-complex-coacervation
#20
Rezvan Shaddel, Javad Hesari, Sodeif Azadmard-Damirchi, Hamed Hamishehkar, Bahram Fathi-Achachlouei, Qingrong Huang
Protein-polysaccharide interactions offer opportunities for designing the new functional foods with applications in the food and pharmaceutical industries. In this work, we microencapsulated black raspberry water extracts by double emulsion technique prior to complex coacervation using gelatin and gum Arabic to diminish the instability of their anthocyanins (ANCs) as water soluble compounds, particularly under harsh processing and storage conditions. Subsequently, optical microscopy, moisture, hygroscopicity, solubility, particle size, loading capacity, zeta potential, color parameters (L*, a*, b*, C, H° and TCD), stability, Fourier transform infrared spectroscopy (FTIR), and thermal behavior were evaluated...
October 10, 2017: International Journal of Biological Macromolecules
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