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Mridul Majumder, Saeid Rajabnezhad, Ali Nokhodchi, Mohammed Maniruzzaman
The current study explores the first case of the implementation of solution calorimetry (SolCal) in order to determine the amorphous content of crystalline benzoyl-methoxy-methylindol-acetic acid (BMA)-a model poorly soluble drug, in the amorphous granules prepared via single-step continuous twin-screw dry granulations (TSG). Amorphous magnesium aluminometasilicate (Neusilin®) (US2) was used as a novel inorganic carrier via a TwinLab 10 mm twin-screw extruder. The BMA/US2 blends were processed at 180 °C and varying drug: carrier ratios of 1:4, 1:2...
April 24, 2018: Drug Delivery and Translational Research
Miguel Ángel Robles-García, Carmen Lizette Del-Toro-Sánchez, Enrique Márquez-Ríos, Arturo Barrera-Rodríguez, Jacobo Aguilar, José A Aguilar, Francisco Javier Reynoso-Marín, I Ceja, R Dórame-Miranda, Francisco Rodríguez-Félix
In this study, cellulose of bagasse from Agave tequilana Weber var. azul was extracted to elaborate nanofibers by the electrospinning technique. Fiber characterization was performed using Transmission Electron Microscopy (TEM), x-ray, Fournier Transform-InfraRed (FT-IR) spectroscopy, and thermal analysis by Differential Scanning Calorimetry-Thermogravimetric Analysis (DSC-TGA). Different diameters (ranging from 54.57 ± 0.02 to 171 ± 0.01 nm) of nanofibers were obtained. Cellulose nanofibers were analyzed by means of x-ray diffraction, where we observed a total loss of crystallinity in comparison with the cellulose, while FT-IR spectroscopy revealed that the hemicellulose and lignin present in the agave bagasse were removed...
July 15, 2018: Carbohydrate Polymers
Albert Nguessan Ngo, Danielle Thomas, James Murowchick, Navid J Ayon, Archana Jaiswal, Bi-Botti Celestin Youan
It is hypothesized that a novel crystalline solid dispersion (CSD) of docetaxel (C-DXT) can be engineered by dispersing native docetaxel (DXT, a class II drug) in sodium acetate crystal (SA). DXT is dissolved in glacial acetic/SA solution and freeze-dried. The C-DXT is characterized by differential scanning calorimetry (DSC), powder X-ray analysis (PXRD), LC-MS/MS, scanning electron microscopy (SEM), transmission electron microscopy (TEM), Quartz crystal microbalance with dissipation monitoring (QCM-D) and dynamic light scattering (DLS)...
April 21, 2018: International Journal of Pharmaceutics
Narendar Dudhipala, Karthik Yadav Janga, Thirupathi Gorre
Nisoldipine (ND) has low oral bioavailability (5%) due to first-pass metabolism. Previously, solid lipid nanoparticles (SLNs) of ND were reported. In this study, nanostructured lipid carriers (NLCs) of ND are developed to enhance the oral bioavailability. ND-NLCs were prepared using hot homogenization-ultrasonication method, using oleic acid and trimyristate as liquid lipid and solid lipid, respectively. Prepared NLCs are evaluated for an optimal system using measuring size, zeta potential, entrapment efficiency, in-vitro release and in-situ absorption studies...
April 24, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Guiyan Sun, Shaobo Lai, Xiangbang Kong, Zhiqiang Chen, Kun Li, Rong Zhou, Jing Wang, Jinbao Zhao
A blend cathode has been prepared by mixing both the LiNi0.5Co0.2Mn0.3O2 (NCM523) of high energy density and high specific capacity and the LiFe0.15Mn0.85PO4/C (LFMP/C) of excellent thermal stability via a low-speed ball-milling method. The lithium ion batteries (LIBs) using the blend cathode with LFMP/C of optimum percent exhibit better capacity retention after 100 cycles than those using only single NCM523 or LFMP/C. Both theoretical simulation and experimental rate performances demonstrate that the electrochemical property of blend cathode materials is predictable and economical...
April 24, 2018: ACS Applied Materials & Interfaces
Svetla Todinova, Yuliana Raynova, Krassimira Idakieva
The thermal unfolding of hemocyanin isoforms, β -HaH and α D + N -HaH, isolated from the hemolymph of garden snails Helix aspersa maxima, was studied by means of differential scanning calorimetry (DSC). One transition, with an apparent transition temperature ( T m ) at 79.88°C, was detected in the thermogram of β -HaH in 20 mM HEPES buffer, containing 0.1 M NaCl, 5 mM CaCl2, and 5 mM MgCl2 , pH 7.0, at scan rate of 1.0°C min-1 . By means of successive annealing procedure, two individual transitions were identified in the thermogram of α D + N -HaH...
2018: Journal of Analytical Methods in Chemistry
Beijing Xue, Wenhao Wang, Litong Guo, Xuanru Ren, Xueyu Tao, Yinghuai Qiang
The titanium opaque porcelain was synthesized through sol-gel using borate-silicate system. The porcelain was characterized by DSC-TG, X-ray diffraction, N2 adsorption-desorption isotherms and scanning electron microscope tests. The results of DSC showed that the nitrates could be decomposed completely when the bioglass xerogel precursor was heat-treated at 760 ℃. The XRD results showed that the Na2 Ca3 Si6 O16 was the major phase of the opaque porcelain. The synthesized opaque porcelain powders had an average particle size of about 5-25 µm with nanopores of around 50-70 nm on the surface...
April 4, 2018: Journal of the Mechanical Behavior of Biomedical Materials
Lalehan Akyuz, Murat Kaya, Muhammad Mujtaba, Sedef Ilk, Idris Sargin, Asier M Salaberria, Jalel Labidi, Yavuz S Cakmak, Cemil Islek
In the current study, capsaicin, a plant alkaloid with high antioxidative, anti-inflammatory, antiobesity, anticancer and analgesic properties, was used in the film technology for the first time. In the same regard, chitosan (as a versatile animal-based polymer) was blended with capsaicin at three different concentrations to obtain edible films. The produced films were characterized by FT-IR, SEM, and DSC. Mechanical, transmittance, hydrophobicity, anti-quorum sensing, antimicrobial and antioxidant properties were also examined...
April 19, 2018: International Journal of Biological Macromolecules
Sara Vieira, Albina R Franco, Emanuel M Fernandes, Sara Amorim, Helena Ferreira, Ricardo A Pires, Rui L Reis, Albino Martins, Nuno M Neves
Fish sarcoplasmic proteins (FSP) constitute around 25-30% of the total fish muscle protein. As the FSP are water soluble, FSP were isolated from fresh cod (Gadus morhua) by centrifugation. By SDS-PAGE, it was possible to determine the composition of FSP extracts (FSP-E). The FSP-E undergo denaturation at 44.12 ± 2.34° C, as characterized by differential scanning calorimetry thermograms (DSC). The secondary structure of FSP-E is mainly composed by α-helix structure, as determined by circular dichroism...
April 5, 2018: Colloids and Surfaces. B, Biointerfaces
Nele-Johanna Hempel, Katharina Brede, Niels Erik Olesen, Natalja Genina, Matthias Manne Knopp, Korbinian Löbmann
The aim of this study was to introduce a fast and reliable differential scanning calorimetry (DSC)-based method to determine the monomolecular loading capacity of drugs with good glass-forming ability in mesoporous silica (MS). The proposed method is based on a solvent-free melting/fusion of drug into the MS during a heat-cool-heat cycle in the DSC. Overloaded drug-MS systems were analyzed in the DSC at different drug ratios (50, 60, 70, 80 and 90% w/w) to quantify the excess drug in the (the fraction not adsorbed to the MS surface)...
April 18, 2018: International Journal of Pharmaceutics
Sameer Jauhar, Mattia Veronese, Matthew M Nour, Maria Rogdaki, Pamela Hathway, Federico E Turkheimer, James Stone, Alice Egerton, Philip McGuire, Shitij Kapur, Oliver D Howes
Psychotic illnesses show variable responses to treatment. Determining the neurobiology underlying this is important for precision medicine and the development of better treatments. It has been proposed that dopaminergic differences underlie variation in response, with striatal dopamine synthesis capacity (DSC) elevated in responders and unaltered in non-responders. We therefore aimed to test this in a prospective cohort, with a nested case-control comparison. 40 volunteers (26 patients with first-episode psychosis and 14 controls) received an 18 F-DOPA Positron Emission Tomography scan to measure DSC (Kicer ) prior to antipsychotic treatment...
April 20, 2018: Molecular Psychiatry
Isabel Andrea Patiño-Márquez, Marcela Manrique-Moreno, Edwin Patiño-González, Małgorzata Jemioła-Rzemińska, Kazimierz Strzałka
Antimicrobial peptides are molecules of natural origin, produced by organisms such as insects, which have focused attention as potential antiparasitic agents. They can cause the death of parasites such Leishmania by interacting with their membrane. In this study, additional information was obtained on how the anionic peptide 2 and cecropin D-like peptide derived from Galleria mellonella interact with liposomes that mimic the composition of the Leishmania membrane. In order to do this, lipid bilayers consisting of dipalmitoylphosphatidylcholine, dipalmitoylphosphatidylethanolamine, dimyristoylphosphatidylserine, and dimyristoylphosphatidylglycerol were constructed...
April 20, 2018: Journal of Antibiotics
Tae Yang Son, Mi Ae Jeong, Sang Yong Nam
Amorphous fluoropolymers have been studied in the past few decades and received extensive attention due to their unique and useful properties. One of the remarkable properties of amorphous fluoropolymers is high fractional free volume (FFV), and they tend to retain large amounts of solvent inside their polymer chains. In this study, amorphous flouoropolymer membranes were employed to examine the influences of the residual solvent and drying condition on the thermal properties, gas permeation behavior, and structure change by the polymer chains...
September 1, 2018: Journal of Nanoscience and Nanotechnology
Suhyun Kim, Moon Il Kim, Minyoung Shon, Bongkuk Seo, Choongsun Lim
Epoxy resins are widely used in various industrial fields due to their low cost, good workability, heat resistance, and good mechanical strength. However, they suffer from brittleness, an issue that must be addressed for further applications. To solve this problem, additional fillers are needed to improve the mechanical and thermal properties of the resins; zirconia is one such filler. However, it has been reported that aggregation may occur in the epoxy composites as the amount of zirconia increases, preventing enhancement of the mechanical strength of the epoxy composites...
September 1, 2018: Journal of Nanoscience and Nanotechnology
Sanjeev Chawla, Sumei Wang, Suyash Mohan, MacLean Nasrallah, Gaurav Verma, Steven Brem, Donald M O'Rourke, Ronald L Wolf, Harish Poptani, S Ali Nabavizadeh
BACKGROUND: Accurate differentiation of brain infections from necrotic glioblastomas (GBMs) may not always be possible on morphologic MRI or on diffusion tensor imaging (DTI) and dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI) if these techniques are used independently. PURPOSE: To investigate the combined analysis of DTI and DSC-PWI in distinguishing brain injections from necrotic GBMs. STUDY TYPE: Retrospective. POPULATION: Fourteen patients with brain infections and 21 patients with necrotic GBMs...
April 20, 2018: Journal of Magnetic Resonance Imaging: JMRI
Marco Caballo, John M Boone, Ritse Mann, Ioannis Sechopoulos
PURPOSE: To develop and evaluate a new automatic classification algorithm able to identify voxels containing skin, vasculature, adipose and fibroglandular tissue in dedicated breast CT images. METHODS: The proposed algorithm combines intensity and region-based segmentation methods with energy minimizing splines and unsupervised data mining approaches for classifying and segmenting the different tissue types. Breast skin segmentation is achieved by a region growing method which uses constraints from the previously extracted skin centerline to add robustness to the model and to reduce the false positive rate...
April 19, 2018: Medical Physics
D Tortora, M Severino, M Pacetti, G Morana, M M Mancardi, V Capra, A Cama, M Pavanello, A Rossi
BACKGROUND AND PURPOSE: Indirect revascularization surgery is an effective treatment in children with Moyamoya vasculopathy. In the present study, we hypothesized that DSC-PWI may reliably assess the evolution of CBF-related parameters after revascularization surgery, monitoring the outcome of surgical pediatric patients with Moyamoya vasculopathy. Thus, we aimed to evaluate differences in DSC-PWI parameters, including the hemodynamic stress distribution, in surgical and nonsurgical children with Moyamoya vasculopathy and to correlate them with long-term postoperative outcome...
April 19, 2018: AJNR. American Journal of Neuroradiology
Zhen Zhang, Junzong Feng, Yonggang Jiang, Ping Liu, Qiuhua Zhang, Ronghui Wei, Xiang Chen, Jian Feng
The conventional sol-gel method for preparing porous carbons is tedious and high-cost to prepare porous carbons and the control over the nanoporous architecture by solvents and carbonization is restricted. A simple and novel self-sacrificial salt templating method was first presented to adjust the microporous structure of porous carbon monoliths synthesized via the solvothermal method. Apart from good monolithic appearance, the solvothermal route allowed for ambient drying because it made sure that the polymerization reaction was completed quickly and thoroughly...
April 19, 2018: Nanomaterials
Farhad Mohammadi, Soliman Mohammadi Samani, Nader Tanideh, Fatemeh Ahmadi
Purpose: Cartilage regeneration by using polymeric scaffolds is a new option for treatment of osteoarthritis. A good scaffold for tissue engineering should copy the characteristics of natural extracellular matrix. The purpose of this study was to make a dosage form with proper reliability and stability for cartilage repair. Methods: Hybrid scaffolds containing different ratios of hyaluronic acid (HA) and collagen were prepared and loaded with prednisolone as anti-inflammatory agent. Two different dosage forms (lyophilized implantable disk and thermo-sensitive gels) were examined...
March 2018: Advanced Pharmaceutical Bulletin
Medhat Wahba Shafaa, Amany Hasan Elshazly, Amira Zaki Dakrory, Maha Reda Elsyed
Purpose: To stress the influence of Coenzyme Q10 (CoQ10) on the structural properties of liposomes as model membranes and to investigate the possible role of CoQ10 or CoQ10 doped in liposomes when topically instilled as eye drops, in preventing cataract. Methods: The molecular interaction between liposomes and Coenzyme Q10 was examined using differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR). Rat pups were randomly divided into six groups comprising 15 pups. Group (1), control group...
March 2018: Advanced Pharmaceutical Bulletin
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