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interleukin 12 gamma interferon

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https://www.readbyqxmd.com/read/27917263/changes-in-cellular-proliferation-and-plasma-products-are-associated-with-liver-failure
#1
Juliana Gil Melgaço, Frederico Marianetti Soriani, Pedro Henrique Ferreira Sucupira, Leonardo Assaf Pinheiro, Yasmine Rangel Vieira, Jaqueline Mendes de Oliveira, Lia Laura Lewis-Ximenez, Cristina Carvalho Vianna Araújo, Lúcio Filgueiras Pacheco-Moreira, Gustavo Batista Menezes, Oswaldo Gonçalves Cruz, Claudia Lamarca Vitral, Marcelo Alves Pinto
AIM: To study the differences in immune response and cytokine profile between acute liver failure and self-limited acute hepatitis. METHODS: Forty-six patients with self-limited acute hepatitis (AH), sixteen patients with acute liver failure (ALF), and twenty-two healthy subjects were involved in this study. The inflammatory and anti-inflammatory products in plasma samples were quantified using commercial enzyme-linked immunoassays and quantitative real-time PCR...
November 18, 2016: World Journal of Hepatology
https://www.readbyqxmd.com/read/27871914/neonatal-levels-of-adiponectin-interleukin-10-and-interleukin-12-are-associated-with-the-risk-of-developing-type-1-diabetes-in-childhood-and-adolescence-a-nationwide-danish-case-control-study
#2
Steffen U Thorsen, Christian B Pipper, Stefanie Eising, Kristin Skogstrand, David M Hougaard, Jannet Svensson, Flemming Pociot
BACKGROUND/AIM: An in-depth understanding of the early phase of type 1 diabetes (T1D) pathogenesis is important for targeting primary prevention. We examined if 14 preselected mediators of immune responses differed in neonates that later developed T1D compared to control neonates. METHODS: The study is a case-control study with a 1:2 matching. The individuals were born between 1981 through 2002. Cases were validated using the National Patient Register and the Danish Childhood Diabetes Register...
November 15, 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/27801673/beauveria-attenuates-asthma-by-inhibiting-inflammatory-response-and-inducing-lymphocytic-cell-apoptosis
#3
Jingying Zhang, Xianmei Zhou, Jiping Zhu
The present study aimed to investigate the role of beauveria (BEA) in asthma. We investigated the cytotoxic effect of BEA on the proliferation of inflammatory cells and secretion of inflammatory mediators both in-vitro and in-vivo. In in-vitro studies, BEA inhibited lymphocytic cell proliferation and the proliferation of lymphocytic cells induced by Phorbol-12-myristate-13-acetate (PMA). We used ELISA to test the effects of BEA on the secretion of inflammatory factors including tumor necrosis factor-alpha (TNF-α), interleukin-12 (IL-12) and interferon-gamma (IFN-γ)...
October 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27798883/influence-of-circulating-tumour-cells-on-production-of-il-1%C3%AE-il-1%C3%AE-and-il-12-in-sera-of-patients-with-primary-diagnosis-of-breast-cancer-before-treatment
#4
Theresa Vilsmaier, Brigitte Rack, Alexander König, Klaus Friese, Wolfgang Janni, Udo Jeschke, Tobias Weissenbacher
BACKGROUND: Circulating tumour cells (CTCs) have been found to be a prognostic marker for reduced disease-free survival (DFS), distant DFS, breast cancer-specific survival, and overall survival (OS) before the start of systemic treatment. Determination of CTCs with the CellSearch System (Veridex, Raritan, NJ, USA) is a valuable but time-consuming and costly method. Therefore, the aim of this study was to evaluate cytokine profiles as a marker for CTC involvement. PATIENTS AND METHODS: Patients chosen for this study were defined as women with breast cancer who agreed to participate in the phase I SUCCESS study...
October 2016: Anticancer Research
https://www.readbyqxmd.com/read/27797254/hepatitis-c-virus-associations-with-non-hodgkin-s-lymphoma-insights-on-in-ammation-angiogenesis-and-cd-markers
#5
Eman A El-Maadawy, Roba M Talaat, Rawia F Sadek, Sherif M El-Sherbini, Naser Abdel-Bary, Amal A Abdel-Aziz
We aimed to investigate any association between hepatitis C virus (HCV) infection and non-Hodgkin's lymphoma (NHL) in the view of cytokines that control in ammation/angiogenesis and their correlation with certain CD markers. NHL patients with or without HCV infection were studied. CD5, CD30, CD3, CD20 and CD45 were immunohistochemically evaluated. Plasma levels of vascular endothelial and platelet derived growth factors (VEGF, and PDGF), tumor necrosis factor (TNF-α), transforming growth factor (TGF-β), interleukin-6 (IL-6), IL-8, IL-4, IL-12 and interferon gamma (IFN-γ) were detected by enzyme-linked immunosorbent assay (ELISA)...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27755461/association-of-mbl2-tlr1-tlr2-and-tlr6-polymorphisms-with-production-of-ifn-%C3%AE-and-il-12-in-bcg-osteitis-survivors
#6
Laura Pöyhönen, Liisa Kröger, Heini Huhtala, Johanna Mäkinen, Kirsi Nuolivirta, Jussi Mertsola, Qiushui He, Matti Korppi
BACKGROUND: Interferon-gamma (IFN-γ) is a key cytokine in defense against mycobacteria, including Bacillus Calmette-Guérin (BCG). Mannose-binding lectin (MBL) and Toll-like receptors (TLRs) are pattern-recognizing molecules of innate immunity. The aim of the present study was to investigate the relationship between polymorphisms in MBL, TLR1, TLR2, and TLR6 encoding genes and stimulated IFN-γ and interleukin-12 (IL-12) ex vivo production in BCG osteitis survivors. METHODS: Data on single nucleotide polymorphisms (SNPs) in the MBL2 gene and TLR1, TLR2, and TLR6 genes were available from 132 former BCG osteitis patients, and data on ex vivo IFN-γ and IL-12 production were available from 115 and 118 patients, respectively...
October 17, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27688626/bronchoalveolar-lavage-fluid-cytokine-bead-array-profile-for-prognostication-of-ventilated-trauma-patients
#7
Subodh Kumar, Nidhi Bhardwaj, Surbhi Khurana, Amit Gupta, Kapil Dev Soni, Richa Aggrawal, Purva Mathur
AIM OF STUDY: Ventilator-associated pneumonia (VAP) is a common cause of mortality in trauma patients admitted to Intensive Care Units. The outcome of such patients may be dependent on local host immune response, which may be best reflected in studies using bronchoalveolar lavage (BAL) fluid. The present study was conducted to ascertain the cytokine profile of BAL using the cytometric bead array (CBA) in a flow cytometer and to correlate the levels of Th-1/Th-2 cytokines in BAL with the clinical outcome of ventilated trauma patients...
September 2016: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/27664570/azithromycin-modulates-immune-response-of-human-monocyte-derived-dendritic-cells-and-cd4-t-cells
#8
Syh-Jae Lin, Ming-Ling Kuo, Hsiu-Shan Hsiao, Pei-Tzu Lee
Azithromycin (AZM) is a macrolide antibiotic that exhibits anti-inflammatory activity aside from its antimicrobial effect, a feature that may ameliorate certain inflammatory disorders and prevent graft-versus-host disease in patients receiving stem cell transplantation. In the present study, we investigated the ability of AZM to influence the function of human monocyte-derived dendritic cells (DCs) and CD4(+) T cells. We found that AZM down-regulated CD80, CD86, and HLA-DR expression in lipopolysaccharide (LPS)-stimulated DCs and suppressed interleukin (IL)-6, IL-10, IL-12, and tumor necrosis factor-alpha production in these cells...
September 21, 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27663623/interleukin-12-modulates-the-immunomodulatory-properties-of-human-periodontal-ligament-cells
#9
B Issaranggun Na Ayuthaya, P Satravaha, P Pavasant
BACKGROUND AND OBJECTIVE: The cytokine interleukin 12 (IL-12) has been implicated as a potent stimulator of tissue degradation in the pathogenesis of several inflammatory diseases, including periodontitis. In patients with periodontitis, an increased level of IL-12 is found in serum and gingival crevicular fluid. As inflammatory cytokines have been demonstrated to induce activation of the immunomodulatory properties of mesenchymal stem cells (MSCs), this study aimed to investigate the influence of IL-12 on these properties in human periodontal ligament (hPDL) cells...
September 24, 2016: Journal of Periodontal Research
https://www.readbyqxmd.com/read/27649674/disseminated-bacille-calmette-gu%C3%A3-rin-disease-in-saudi-children-clinical-profile-microbiology-immunology-evaluation-and-outcome
#10
E Bukhari, F Alaklobi, H Bakheet, A Alrabiaah, F Alotibi, F Aljobair, M Alshamrani, E Alaki, F Alnahdi, A Alodyani, F Alzamil
OBJECTIVE: The bacille Calmette Guérin (BCG) vaccine is administered worldwide to prevent tuberculosis. Although, Post BCG vaccination complications like disseminated BCG infections are rare and immunocompromised children are at high risk of developing BCG-related complications including BCG-lymphadenitis and other disseminated diseases. PATIENTS AND METHODS: This was a prospective study of children who developed disseminated BCG after vaccination who were admitted in three tertiary care hospital in Riyadh, Saudi Arabia, in the year 2015...
September 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27642351/in-vivo-interrelationship-between-insulin-resistance-and-interferon-gamma-production-protective-and-therapeutic-effect-of-berberine
#11
Mohammad Ahmad Mahmoud, Doaa Ahmad Ghareeb, Heba Abdelghany Sahyoun, Ashraf Abdelhamed Elshehawy, Mohammad Mohammad Elsayed
This research was conducted to investigate if there is a relation between insulin resistance incidence and inhibition of interferon gamma production or not. Firstly, insulin resistance was induced by high fat diet (HFD) intake for 6 weeks. Secondly, berberine was used as protective/curative compound for insulin resistance. Results revealed that feeding rats HFD for 6 weeks developed features of insulin resistance (IR) syndrome. These features presented in increased body weight, hyperglycemia, hyperinsulinemia, hypercholesterolemia (with increased LDL-cholesterol and decreased HDL-cholesterol), and hypertriglyceridemia...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27638118/clinical-improvement-in-feline-herpesvirus-1-infected-cats-by-oral-low-dose-of-interleukin-12-plus-interferon-gamma
#12
Filomena Fiorito, Antonietta Cantiello, Giovanna Elvira Granato, Luigi Navas, Carmine Diffidenti, Luisa De Martino, Veeramani Maharajan, Fabio Olivieri, Ugo Pagnini, Giuseppe Iovane
Feline herpesvirus 1 (FHV-1) is a widespread cat pathogen inducing rhinitis, conjunctivitis and corneal ulcers. To alleviate acute FHV-1-induced disease, antiviral agents are used often with antibiotics. But sometimes, these treatments, as well as conventional doses of cytokines have moderate efficacy and/or collateral effects. Herein we have investigated the effects of low dose interleukin (IL)-12 plus interferon (IFN)-gamma, prepared by Sequential Kinetic Activated (SKA), on the treatment of FHV-1 infection...
October 2016: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/27622168/effect-of-moderate-exercise-on-serum-interferon-gamma-and-interleukin-17-levels-in-the-morphine-withdrawal-period
#13
Ali Heidarianpour, Majid Vahidian Rezazadeh, Alireza Zamani
BACKGROUND: Drug addiction triggers the infliction of a variety of diseases. Various subjects have indicated that during the withdrawal syndrome period, the immune system is weakened. OBJECTIVES: This study aimed to investigate the changes in serum levels of interferon-gamma (IFN-γ) and interleukin-17 (IL-17) during the morphine withdrawal syndrome induced by 8 weeks of moderate exercise and their effects on the immune system function. MATERIALS AND METHODS: Twenty-four male Wistar rats (220 ± 10 g) were divided into four groups (n = 6): healthy control (HC), addicted control (AC), healthy trained (HT), and addicted trained (AT) groups...
June 2016: International Journal of High Risk Behaviors & Addiction
https://www.readbyqxmd.com/read/27600707/multiplex-immunoassay-characterization-and-species-comparison-of-inflammation-in-acute-and-non-acute-ischemic-infarcts-in-human-and-mouse-brain-tissue
#14
Thuy-Vi V Nguyen, Jennifer B Frye, Jacob C Zbesko, Kristina Stepanovic, Megan Hayes, Alex Urzua, Geidy Serrano, Thomas G Beach, Kristian P Doyle
This study provides a parallel characterization of the cytokine and chemokine response to stroke in the human and mouse brain at different stages of infarct resolution. The study goal was to address the hypothesis that chronic inflammation may contribute to stroke-related dementia. We used C57BL/6 and BALB/c mice to control for strain related differences in the mouse immune response. Our data indicate that in both mouse strains, and humans, there is increased granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin-6 (IL-6), interleukin-12 p70 (IL-12p70), interferon gamma-induced protein-10 (IP-10), keratinocyte chemoattractant/interleukin-8 (KC/IL-8), monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1α (MIP-1α), macrophage inflammatory protein-1β (MIP-1β), regulated on activation, normal T cell expressed and secreted (RANTES), and Tumor necrosis factor-α (TNF-α) in the infarct core during the acute time period...
September 6, 2016: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/27584662/role-of-interleukin-10-on-nasal-polypogenesis-in-patients-with-chronic-rhinosinusitis-with-nasal-polyps
#15
Jun Xu, Ruining Han, Dae Woo Kim, Ji-Hun Mo, Yongde Jin, Ki-Sang Rha, Yong Min Kim
BACKGROUND AND OBJECTIVES: Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine. The dysregulation of IL-10 is associated with an enhanced immunopathologic response to infection, as well as with an increased risk for developing numerous autoimmune diseases. In this study, we investigated IL-10 expression in chronic rhinosinusitis with nasal polyps (CRSwNP) and assessed the possible role of IL-10 in the pathogenesis of CRSwNP. MATERIALS AND METHODS: Thirty-five patients with CRSwNP, 12 patients with chronic rhinosinusitis without NP (CRSsNP) and 10 control subjects were enrolled in this study...
2016: PloS One
https://www.readbyqxmd.com/read/27577059/investigation-of-the-immunomodulatory-effect-of-berberis-vulgaris-on-core-pulsed-dendritic-cell-vaccine
#16
Doaa A Ghareeb, Eiman H Elwakeel, Rowaida Khalil, Mina S Aziz, Maha A El Demellawy
BACKGROUND: Virus-induced dendritic cells (DCs) functional deficiency leads to sub-optimal initiation of adaptive immune responses and consequently chronic infection establishment. The present study reports an advanced hepatitis C virus (HCV) therapeutic vaccine model based on In vivo enrichment of DCs with barberry ethanolic crude extract (BCE) then pulsing them with HCV core protein. METHODS: DCs were enriched by BCE intravenous injection in BALB/c mice. Vaccine efficiency was assessed by flow cytometric analysis of splenocytes of immunized mice, cytokine profiling, cytotoxic T lymphocyte assay, and humoral immune response assessment...
2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27574013/establishment-of-a-murine-model-of-cerebral-malaria-in-kunming-mice-infected-with-plasmodium-berghei-anka
#17
Yan Ding, Wenyue Xu, Taoli Zhou, Taiping Liu, Hong Zheng, Yong Fu
Malaria remains one of the most devastating diseases. Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection resulting in high mortality and morbidity worldwide. Analysis of precise mechanisms of CM in humans is difficult for ethical reasons and animal models of CM have been employed to study malaria pathogenesis. Here, we describe a new experimental cerebral malaria (ECM) model with Plasmodium berghei ANKA infection in KunMing (KM) mice. KM mice developed ECM after blood-stage or sporozoites infection, and the development of ECM in KM mice has a dose-dependent relationship with sporozoites inoculums...
October 2016: Parasitology
https://www.readbyqxmd.com/read/27563636/in-vivo-in-vitro-immune-responses-to-l-major-isolates-from-patients-with-no-clinical-response-to-glucantime
#18
Sedigheh Saberi, Reza Arjmand, Simindokht Soleimanifard, Ali Khamesipour, Seyed Mohsen Hosseini, Mansoor Salehi, Jaleh Varshosaz, Abbas Ali Palizban, Seyed Hossein Hejazi
BACKGROUND: Leishmaniasis is a major health problem in some endemic areas of tropical and subtropical areas of the world. Interleukin-12 (IL-12) and interferon gamma (IFN-γ) are essential cytokines associated with initiation of Th1 response. The main objective of this study was to evaluate of the type of immune response to L. major isolates from patients with no clinical response to antimonite (Glucantime). MATERIALS AND METHODS: This experimental study was carried out during 2013-2014...
2016: Advanced Biomedical Research
https://www.readbyqxmd.com/read/27556483/evaluation-of-the-cross-protective-efficacy-of-a-chimeric-porcine-reproductive-and-respiratory-syndrome-virus-constructed-based-on-two-field-strains
#19
Nadeem Shabir, Amina Khatun, Salik Nazki, Bumseok Kim, Eun-Jin Choi, Dong Sun, Kyoung-Jin Yoon, Won-Il Kim
One of the major hurdles to porcine reproductive and respiratory syndrome (PRRS) vaccinology is the limited or no cross-protection conferred by current vaccines. To overcome this challenge, a PRRS chimeric virus (CV) was constructed using an FL12-based cDNA infectious clone in which open reading frames (ORFs) 3-4 and ORFs 5-6 were replaced with the two Korean field isolates K08-1054 and K07-2273,respectively. This virus was evaluated as a vaccine candidate to provide simultaneous protection against two genetically distinct PRRS virus (PRRSV) strains...
2016: Viruses
https://www.readbyqxmd.com/read/27536272/differential-biphasic-transcriptional-host-response-associated-with-coevolution-of-hemagglutinin-quasispecies-of-influenza-a-virus
#20
Himanshu Manchanda, Nora Seidel, Markus F Blaess, Ralf A Claus, Joerg Linde, Hortense Slevogt, Andreas Sauerbrei, Reinhard Guthke, Michaela Schmidtke
Severe influenza associated with strong symptoms and lung inflammation can be caused by intra-host evolution of quasispecies with aspartic acid or glycine in hemagglutinin position 222 (HA-222D/G; H1 numbering). To gain insights into the dynamics of host response to this coevolution and to identify key mechanisms contributing to copathogenesis, the lung transcriptional response of BALB/c mice infected with an A(H1N1)pdm09 isolate consisting HA-222D/G quasispecies was analyzed from days 1 to 12 post infection (p...
2016: Frontiers in Microbiology
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