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https://www.readbyqxmd.com/read/29456832/interleukin-25-and-eosinophils-progenitor-cell-mobilization-in-allergic-asthma
#1
Wei Tang, Steven G Smith, Wei Du, Akash Gugilla, Juan Du, John Paul Oliveria, Karen Howie, Brittany M Salter, Gail M Gauvreau, Paul M O'Byrne, Roma Sehmi
Background: Eosinophil-lineage committed progenitor cells (EoP) migrate from the bone marrow and differentiate locally to provide an ongoing source of mature eosinophils in asthmatic inflammatory responses in the airways. Sputum levels of EoP are increased in asthmatics compared to normal controls suggesting an exaggerated eosinophilopoietic environment in the airways. Understanding what factors promote EoP traffic to the airways is important to understand the diathesis of asthma pathology...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29455499/-lateral-closing-wedge-osteotomy-and-modified-cross-pinning-with-external-tension-band-fixation-in-the-treatment-of-cubitus-varus-deformity-in-childrenlateral-closing-wedge-osteotomy-and-modified-cross-pinning-with-external-tension-band-fixation-in-the-treatment
#2
Chuan Zhang, Zuo-Jun Zhang, Lei Wang, Zhong-Xiao Chang, Lin-Ping Yang, Ming Zhao, Xing-Xing Li, Rui-Ping Feng, Guo-Jie Wang, Xiao-Bo Duan
OBJECTIVE: To explore the therapeutic effects of distal humeral lateral closing wedge osteotomy followed by modified pinning combined with external tension band fixation in the treatment of cubitus varus deformity in children. METHODS: Total 26 adult patients with cubitus varus deformity were treated by operation from March 2011 to June 2015, 15 patients were boys and the other 11 patients were girls, ranging in age from 4 to 13 years, with an average of 7.8 years...
August 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29455436/older-adults-in-jail-high-rates-and-early-onset-of-geriatric-conditions
#3
Meredith Greene, Cyrus Ahalt, Irena Stijacic-Cenzer, Lia Metzger, Brie Williams
BACKGROUND: The number of older adults in the criminal justice system is rapidly increasing. While this population is thought to experience an early onset of aging-related health conditions ("accelerated aging"), studies have not directly compared rates of geriatric conditions in this population to those found in the general population. The aims of this study were to compare the burden of geriatric conditions among older adults in jail to rates found in an age-matched nationally representative sample of community dwelling older adults...
February 17, 2018: Health & Justice
https://www.readbyqxmd.com/read/29455009/protecting-an-adult-identity-a-grounded-theory-of-supportive-care-for-young-adults-recently-diagnosed-with-cancer
#4
Louise Soanes, Faith Gibson
BACKGROUND: For adolescents and young adults living in high-income countries cancer remains the most common disease-related death. Increasing survival rates and projected longevity are positive outcomes, although long-term consequences of cancer and/or its treatment will likely increase the global burden of cancer. In low and middle-income countries the impact and needs of young adults with cancer are largely unknown and require further attention. However, universal studies have revealed that cancer-related needs for this group are multifactorial, complex and largely unmet...
January 31, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29451922/identifying-classifier-input-signals-to-predict-a-cross-slope-during-transtibial-amputee-walking
#5
Courtney E Shell, Glenn K Klute, Richard R Neptune
Advanced prosthetic foot designs often incorporate mechanisms that adapt to terrain changes in real-time to improve mobility. Early identification of terrain (e.g., cross-slopes) is critical to appropriate adaptation. This study suggests that a simple classifier based on linear discriminant analysis can accurately predict a cross-slope encountered (0°, -15°, 15°) using measurements from the residual limb, primarily from the prosthesis itself. The classifier was trained and tested offline using motion capture and in-pylon sensor data collected during walking trials in mid-swing and early stance...
2018: PloS One
https://www.readbyqxmd.com/read/29449851/divergent-n-deficiency-dependent-senescence-and-transcriptome-response-in-developmentally-old-and-young-brassica-napus-leaves
#6
Vajiheh Safavi-Rizi, Jürgen Franzaring, Andreas Fangmeier, Reinhard Kunze
In the spring oilseed rape (OSR) cultivar 'Mozart' grown under optimal N supply (N O ) or mild N deficiency (N L ) the transcriptome changes associated with progressing age until early senescence in developmentally old lower canopy leaves (leaf #4) and younger higher canopy leaves (leaf #8) were investigated. Twelve weeks old N O and N L plants appeared phenotypically and transcriptomically identical, but thereafter distinct nutrition-dependent differences in gene expression patterns in lower and upper canopy leaves emerged...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29449202/a-web-based-psychoeducational-intervention-for-adolescent-depression-design-and-development-of-moodhwb
#7
Rhys Bevan Jones, Anita Thapar, Frances Rice, Harriet Beeching, Rachel Cichosz, Becky Mars, Daniel J Smith, Sally Merry, Paul Stallard, Ian Jones, Ajay K Thapar, Sharon A Simpson
BACKGROUND: Depression is common in adolescence and leads to distress and impairment in individuals, families and carers. Treatment and prevention guidelines highlight the key role of information and evidence-based psychosocial interventions not only for individuals but also for their families and carers. Engaging young people in prevention and early intervention programs is a challenge, and early treatment and prevention of adolescent depression is a major public health concern. There has been growing interest in psychoeducational interventions to provide accurate information about health issues and to enhance and develop self-management skills...
February 15, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/29448164/the-toxicology-of-indium-oxide
#8
REVIEW
Ernst M Bomhard
Indium oxide (In 2 O 3 ) is a technologically important semiconductor essentially used, doped with tin oxide, to form indium tin oxide (ITO). It is poorly soluble in all so far tested physiologic media. After repeated inhalation, In 2 O 3 particles accumulate in the lungs. Their mobilization can cause significant systemic exposure over long periods of time. An increasing number of cases of severe lung effects (characterized by pulmonary alveolar proteinosis, emphysema and/or interstitial fibrosis) in workers of the ITO industry warrants a review of the toxicological hazards also of In 2 O 3 ...
February 7, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29448133/exposure-to-the-rock-inhibitor-fasudil-promotes-gliogenesis-of-neural-stem-cells-in-vitro
#9
Zubair Ahmed Nizamudeen, Lisa Chakrabarti, Virginie Sottile
Fasudil is a clinically approved Rho-associated protein kinase (ROCK) inhibitor that has been used widely to treat cerebral consequences of subarachnoid hemorrhage. It is known to have a positive effect on animal models of neurological disorders including Parkinson's disease and stroke. However, its cellular effect on progenitor populations and differentiation is not clearly understood. While recent studies suggest that fasudil promotes the mobilization of neural stem cells (NSCs) from the subventricular zone in vivo and promotes the differentiation of the C17...
February 6, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29447754/strontium-isotopic-aspects-of-paranthropus-robustus-teeth-implications-for-habitat-residence-and-growth
#10
Andrew Sillen, Vincent Balter
The strontium isotopic ratio 87 Sr/ 86 Sr has been studied in the Sterkfontein Valley of South Africa to infer both habitat usage and residence for a number of early hominins. This paper examines the existing 87 Sr/ 86 Sr data collectively derived from three studies of Paranthropus robustus teeth with the aim of exploring whether the dataset as a whole may provide deeper insight into habitat, mobility, and growth for this species. 87 Sr/ 86 Sr from seven Swartkrans Member I third molars varies in a well defined narrow range, and while some canines were consistent with this range, a number of P...
January 2018: Journal of Human Evolution
https://www.readbyqxmd.com/read/29447753/kinematics-of-the-anthropoid-os-centrale-and-the-functional-consequences-of-scaphoid-centrale-fusion-in-african-apes-and-hominins
#11
Caley M Orr
In most primates, the os centrale is interposed between the scaphoid, trapezoid, trapezium, and head of the capitate, thus constituting a component of the wrist's midcarpal complex. Scaphoid-centrale fusion is among the clearest morphological synapomorphies of African apes and hominins. Although it might facilitate knuckle-walking by increasing the rigidity and stability of the radial side of the wrist, the exact functional significance of scaphoid-centrale fusion is unclear. If fusion acts to produce a more rigid radial wrist that stabilizes the hand and limits shearing stresses, then in taxa with a free centrale, it should anchor ligaments that check extension and radial deviation, but exhibit motion independent of the scaphoid...
January 2018: Journal of Human Evolution
https://www.readbyqxmd.com/read/29439771/osteoporotic-pelvic-fractures
#12
Ludwig Oberkircher, Steffen Ruchholtz, Pol Maria Rommens, Alexander Hofmann, Benjamin Bücking, Antonio Krüger
BACKGROUND: The estimated incidence of osteoporotic pelvic fractures among persons over age 60 in Germany is 224 per 100 000 persons per year, and rising. A number of surgical treatment options are available, but clinical long-term data are lacking. METHODS: This review is based on pertinent publications and guidelines retrieved by a selective literature search, and on the authors' clinical experience. RESULTS: Patients often report one or more relatively trivial traumatic incidents leading up to the fracture...
February 2, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29439353/evaluating-peripersonal-space-through-the-functional-transcranial-doppler-are-we-paving-the-way-for-early-detecting-mild-cognitive-impairment-to-dementia-conversion
#13
Angela Marra, Antonino Naro, Antonino Chillura, Alessia Bramanti, Giuseppa Maresca, Rosaria De Luca, Alfredo Manuli, Placido Bramanti, Rocco Salvatore Calabrò
BACKGROUND: Identifying the patients with mild cognitive impairment (MCI) who may develop dementia (MDC) is challenging. The study of peripersonal space (PPS) by using functional transcranial Doppler (fTCD) could be used for this purpose. OBJECTIVE: To identify changes in cerebral blood flow (CBF) during motor tasks targeting PPS, which can predict MDC. METHODS: We evaluated the changes in CBF in 22 patients with MCI and 23 with dementia [Alzheimer's disease (AD) and vascular dementia (VaD)] during a motor task (passive mobilization, motor imagery, and movement observation) in which the hand of the subject moved forward and backward the face...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29436627/combination-of-runx2-and-cbf%C3%AE-upregulates-amelotin-gene-expression-in-ameloblasts-by-directly-interacting-with-cis%C3%A2-enhancers-during-amelogenesis
#14
Xiaoying Liu, Yumin Wang, Li Zhang, Zhenzhen Xu, Qing Chu, Chang Xu, Yan Sun, Yuguang Gao
Amelotin (Amtn) is a recently identified enamel protein secreted by ameloblasts at late stage of enamel development. Runt‑related transcription factor 2 (Runx2) in combination with the coactivator core‑binding factor β (Cbfβ) regulates the early stages of tooth development. The aim of the present study was to investigate the role of Runx2 in the regulation of Amtn gene expression in ameloblasts. Immunohistochemistry was performed and the results revealed that Runx2 protein was predominantly expressed in the nuclei of ameloblasts during the transition stage and the maturation stage of enamel development, whereas Cbfβ was expressed in ameloblasts from the secretory stage to the maturation stage...
February 6, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29434719/ag490-ameliorates-early-brain-injury-via-inhibition-of-jak2-stat3-mediated-regulation-of-hmgb1-in-subarachnoid-hemorrhage
#15
Ji-Yang An, Hong-Gang Pang, Ting-Qin Huang, Jin-Ning Song, Dan-Dong Li, Yong-Lin Zhao, Xu-Dong Ma
High mobility group box 1 (HMGB1) is a classic damage-associated molecular pattern that has an important role in the pathological inflammatory response. In vitro studies have demonstrated that the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway is involved in the regulation of HMGB1 expression, mediating the inflammatory response. Therefore, the purpose of the present study was to evaluate JAK2/STAT3 pathway involvement in the subarachnoid hemorrhage (SAH)-dependent regulation of HMGB1, using an in vivo rat model...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434569/cranio-caudal-kinematic-turn-signature-assessed-with-inertial-systems-as-a-marker-of-mobility-deficits-in-parkinson-s-disease
#16
Karina Lebel, Christian Duval, Hung Phuc Nguyen, Réjean Plamondon, Patrick Boissy
Background: Turning is a challenging mobility task requiring proper planning, coordination, and postural stability to be executed efficiently. Turn deficits can impair mobility and lead to falls in patients with neurodegenerative disease, such as Parkinson's disease (PD). It was previously shown that the cranio-caudal sequence involved during a turn (i.e., motion is initiated by the head, followed by the trunk) exhibits a signature that can be captured using an inertial system and analyzed through the Kinematics Theory...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29434016/increasing-physical-activity-amongst-overweight-and-obese-cancer-survivors-using-an-alexa-based-intelligent-agent-for-patient-coaching-protocol-for-the-physical-activity-by-technology-help-path-trial
#17
Ahmed Hassoon, Jennifer Schrack, Daniel Naiman, Dina Lansey, Yasmin Baig, Vered Stearns, David Celentano, Seth Martin, Lawrence Appel
BACKGROUND: Physical activity has established health benefits, but motivation and adherence remain challenging. OBJECTIVE: We designed and launched a three-arm randomized trial to test artificial intelligence technology solutions to increase daily physical activity in cancer survivors. METHODS: A single-center, three-arm randomized clinical trial with an allocation ration of 1:1:1: (A) control, in which participants are provided written materials about the benefits of physical activity; (B) text intervention, where participants receive daily motivation from a fully automated, data-driven algorithmic text message via mobile phone (Coachtext); and (C) Voice Assist intervention, where participants are provided with an in-home on demand autonomous Intelligent Agent using data driven Interactive Digital Voice Assist on the Amazon Alexa/Echo (MyCoach)...
February 12, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29433537/effect-of-mobile-health-on-maternal-health-care-service-utilization-in-eastern-ethiopia-study-protocol-for-a-randomized-controlled-trial
#18
Tilayie Feto Gelano, Nega Assefa, Yadeta Dessie Bacha, Afendi Abdi Mahamed, Kedir Teji Roba, Mitiku Teshome Hambisa
BACKGROUND: Globally, the rapid development of mobile technology has created new ways of addressing public health challenges and shifted the paradigm of health care access and delivery. The primary aim of this study is to examine the effectiveness of Mobile-health on maternal health care service utilization in Eastern Ethiopia. METHODS/DESIGN: Through, a cluster-randomized controlled trial, 640 participants will be selected based on their districts and respective health centers as the unit of randomization...
February 12, 2018: Trials
https://www.readbyqxmd.com/read/29432045/a-conditional-economic-incentive-fails-to-improve-linkage-to-care-and-antiretroviral-therapy-initiation-among-hiv-positive-adults-in-cape-town-south-africa
#19
Brendan Maughan-Brown, Philip Smith, Caroline Kuo, Abigail Harrison, Mark N Lurie, Linda-Gail Bekker, Omar Galárraga
Interventions to improve antiretroviral therapy (ART) access are urgently needed to maximize the multiple benefits from ART. This pilot study examined the effect of a conditional economic incentive on linkage to care and uptake of treatment following ART referral by a mobile health clinic. Between April 2015 and May 2016, 86 individuals (≥18 years old) referred for ART in a resource-limited setting were randomized (1:1) to a control group or to an incentive: R300 cash (∼$23, or 3.5 days minimum wage in the domestic worker sector), conditional upon starting ART within 3 months...
February 2018: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29431227/parasitic-copepods-affect-morphospace-and-diet-of-larvae-of-a-temperate-reef-fish
#20
N Jahnsen-Guzmán, V Bernal-Durán, M F Landaeta
The effects of ectoparasites on larvae of the clingfish Gobiesox marmoratus were evaluated at the dietary and morphometric levels. The larvae and ectoparasites were collected by nearshore plankton samplings during October, November and December 2013 off El Quisco Bay, central Chile. The standardized abundance of total larvae and those ectoparasitized larvae (PL) was positively related and high parasite prevalence was found throughout the sampling period (up to 38%). Geometric morphometrics analyses indicate main changes in the shape through early ontogeny and subtle but significant variations between PL and non-parasitized larvae (NPL)...
February 2018: Journal of Fish Biology
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