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https://www.readbyqxmd.com/read/29908952/recognition-memory-advantage-for-negative-emotional-words-has-an-early-expiry-date-evidence-from-brain-oscillations-and-erps
#1
G Santaniello, P Ferré, P Rodríguez-Gómez, C Poch, M Moreno Eva, J A Hinojosa
Evidence from prior studies has shown an advantage in recognition memory for emotional compared to neutral words. Whether this advantage is short-lived or rather extends over longer periods, as well as whether the effect depends on words' valence (i.e., positive or negative), remains unknown. In the present ERP/EEG study, we investigated this issue by manipulating the lag distance (LAG-2, LAG-8 and LAG-16) between the presentation of old and new words in an online recognition memory task. LAG differences were observed at behavior, ERPs and in the theta frequency band...
June 14, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29908356/total-hip-arthroplasty-after-failed-fixation-of-a-proximal-femur-fracture-analysis-of-59-cases-of-intra-and-extra-capsular-fractures
#2
Antoine Morice, Florian Ducellier, Pascal Bizot
INTRODUCTION: The indications for total hip arthroplasty (THA) after failed internal fixation of a proximal femur fracture vary. Published studies on this topic are broad-ranging and do not distinguish between intracapsular and extracapsular fractures. This led us to conduct a retrospective analysis comparing the clinical outcomes, radiological outcomes, technical problems and complications between these two types of fractures. HYPOTHESIS: The functional outcomes of THA after an extracapsular fracture will be worse than the ones after an intracapsular fracture...
June 13, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29907900/-anesthesia-ventilation-and-pain-treatment-in-thoracic-trauma
#3
REVIEW
M Weigeldt, M Paul, S Schulz-Drost, M D Schmittner
The management of anesthesia plays a central role in the treatment of thoracic trauma, both in the initial phase when safeguarding the difficult airway and in the intensive care unit. A rapid transfer to a trauma center should be considered in order to recognize and treat organ dysfunction in time. Development of atelectasis, pneumonia and acute lung failure are common pulmonary complications. Non-invasive ventilation combined with physiotherapy and respiratory training can help to minimize these pulmonary complications...
June 15, 2018: Der Unfallchirurg
https://www.readbyqxmd.com/read/29907658/degradation-of-dendritic-cargos-requires-rab7-dependent-transport-to-somatic-lysosomes
#4
Chan Choo Yap, Laura Digilio, Lloyd P McMahon, A Denise R Garcia, Bettina Winckler
Neurons are large and long lived, creating high needs for regulating protein turnover. Disturbances in proteostasis lead to aggregates and cellular stress. We characterized the behavior of the short-lived dendritic membrane proteins Nsg1 and Nsg2 to determine whether these proteins are degraded locally in dendrites or centrally in the soma. We discovered a spatial heterogeneity of endolysosomal compartments in dendrites. Early EEA1-positive and late Rab7-positive endosomes are found throughout dendrites, whereas the density of degradative LAMP1- and cathepsin (Cat) B/D-positive lysosomes decreases steeply past the proximal segment...
June 15, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29907556/veterans-perspectives-on-fitbit-use-in-treatment-for-post-traumatic-stress-disorder-an-interview-study
#5
Ada Ng, Madhu Reddy, Alyson K Zalta, Stephen M Schueller
BACKGROUND: The increase in availability of patient data through consumer health wearable devices and mobile phone sensors provides opportunities for mental health treatment beyond traditional self-report measurements. Previous studies have suggested that wearables can be effectively used to benefit the physical health of people with mental health issues, but little research has explored the integration of wearable devices into mental health care. As such, early research is still necessary to address factors that might impact integration including patients' motivations to use wearables and their subsequent data...
June 15, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/29907270/avoiding-respiratory-and-peripheral-muscle-injury-during-mechanical-ventilation-diaphragm-protective-ventilation-and-early-mobilization
#6
REVIEW
Annia Schreiber, Michele Bertoni, Ewan C Goligher
Both limb muscle weakness and respiratory muscle weakness are exceedingly common in critically ill patients. Respiratory muscle weakness prolongs ventilator dependence, predisposing to nosocomial complications and death. Limb muscle weakness persists for months after discharge from intensive care and results in poor long-term functional status and quality of life. Major mechanisms of muscle injury include critical illness polymyoneuropathy, sepsis, pharmacologic exposures, metabolic derangements, and excessive muscle loading and unloading...
July 2018: Critical Care Clinics
https://www.readbyqxmd.com/read/29907230/a-novel-retinoid-x-receptor-agonist-uab30-inhibits-rhabdomyosarcoma-cells-in-vitro
#7
Adele P Williams, Alicia M Waters, Jerry E Stewart, Venkatram R Atigadda, Elizabeth Mroczek-Musulman, Donald D Muccio, Clinton J Grubbs, Elizabeth A Beierle
BACKGROUND: While patients with early-stage rhabdomyosarcoma (RMS) have seen steady improvement in prognosis over the last 50 y, those with advanced-stage or high-grade disease continue to have a dismal prognosis. Retinoids have been shown to cause growth suppression and terminal differentiation in RMS cells, but the toxicities associated with retinoic acid limit its use. Rexinoids provide an alternative treatment approach to retinoic acid. Rexinoids primarily bind the retinoid X receptor with minimal retinoic acid receptor binding, the entity responsible for many of the toxicities of retinoid therapies...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29906277/can-ultrasound-measures-of-intrinsic-foot-muscles-and-plantar-soft-tissues-predict-future-diabetes-related-foot-disease-a-systematic-review
#8
Troy Morrison, Sara Jones, Ryan S Causby, Kerry Thoirs
INTRODUCTION: Diabetes mellitus (DM) is associated with hyperglycaemia and advanced glycosylation end-products. In the foot, the consequences of chronic or uncontrolled diabetes are micro and macrovascular disease, neuropathy, reduced joint mobility and structural and soft tissue changes that increase the risk of ulcer development and amputation. Diabetes foot assessment currently includes a comprehensive history, neurological and vascular assessments and examination focussed on dermatological and musculoskeletal abnormalities...
2018: PloS One
https://www.readbyqxmd.com/read/29905975/the-grk2-promoter-is-regulated-by-early-growth-response-transcription-factor-egr-1
#9
Stefanie Klenke, Andrea Engler, Daniel Ecker, Crista Ochsenfarth, Nina Danowski, Jürgen Peters, Winfried Siffert, Ulrich H Frey
The G-protein-coupled receptor kinase 2 (GRK2) plays a major role in cardiovascular diseases and its expression is increased in heart failure. However, only little is known about factors being involved in up-regulation of GRK2 expression through transcriptional regulation of its promoter. Since the transcription factor early-growth response 1 (EGR-1) is also up-regulated in patients with heart failure, we tested the hypothesis that EGR-1 regulates GRK2 transcription. Stimulation of immortalized rat cardiomyocytes (H9c2) with phorbol 12-myristate 13-acetate (PMA) resulted in up-regulation of Egr-1 and subsequently of Grk2 mRNA expression, with maximum Grk2 expression (p=0...
June 15, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29903582/measuring-disease-progression-and-disability-in-orthostatic-tremor
#10
Nirosen Vijiaratnam, Dharshana Sirisena, Eldho Paul, Kelly L Bertram, David R Williams
OBJECTIVE: To develop a questionnaire quantifying the impact of orthostatic tremor (OT) on patients' function and quality of life to enable longitudinal measurement of disease severity. METHODS: Patients with OT were interviewed in order to identify domains for a new disease-specific impact profile. The OT impact profile (OTIP) included forty-seven items across activities of daily living (9), mobility (9), social participation (2), assistance (8) and emotional effects (19) scored from 0 to 4 (total range 0-188)...
June 8, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29902939/dose-of-early-therapeutic-mobility-does-frequency-or-intensity-matter
#11
Chris Winkelman, Abdus Sattar, Hasina Momotaz, Kimberly D Johnson, Peter Morris, James R Rowbottom, John Daryl Thornton, Sheryl Feeney, Alan Levine
OBJECTIVE: Investigate the feasibility of a nurse-led mobility protocol and compare the effects of once- versus twice-daily episodes of early therapeutic mobility (ETM) and low- versus moderate-intensity ETM on serum biomarkers of inflammation and selected outcomes in critically ill adults. DESIGN: Randomized interventional study with repeated measures and blinded assessment of outcomes. SETTING: Four adult intensive care units (ICUs) in two academic medical centers...
January 1, 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29902168/peer-delivered-linkage-case-management-and-same-day-art-initiation-for-men-and-young-persons-with-hiv-infection-eswatini-2015-2017
#12
Duncan MacKellar, Daniel Williams, Bonsile Bhembe, Makhosazana Dlamini, Johnita Byrd, Lenhle Dube, Sikhathele Mazibuko, Trong Ao, Ishani Pathmanathan, Andrew F Auld, Pamela Faura, Nomthandazo Lukhele, Caroline Ryan
To achieve epidemic control of human immunodeficiency virus (HIV) infection, sub-Saharan African countries are striving to diagnose 90% of HIV infections, initiate and retain 90% of HIV-diagnosed persons on antiretroviral therapy (ART), and achieve viral load suppression* for 90% of ART recipients (90-90-90) (1). In Eswatini (formerly Swaziland), the country with the world's highest estimated HIV prevalence (27.2%), achieving 90-90-90 depends upon improving access to early ART for men and young adults with HIV infection, two groups with low ART coverage (1-3)...
June 15, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29902102/previous-experience-and-walking-capacity-predict-community-outings-after-stroke-an-observational-study
#13
Aspasia Karageorge, Janine Vargas, Louise Ada, Patrick J Kelly, Annie McCluskey
BACKGROUND: Following hospital discharge, stroke survivors may experience a decline in mobility, outings, and community participation. The aim of this study was to examine the relationship between demographic and clinical measures, and the level of participation by community-dwelling stroke survivors. METHODS: A prospective, multicenter, observational study was conducted. Participants were 83 community-dwelling stroke survivors with participation goals who were undergoing post-inpatient rehabilitation in Australia...
June 14, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29901537/an-evidence-based-approach-to-the-management-of-children-with-morquio-a-syndrome-presenting-with-craniocervical-pathology
#14
Nicole Williams, Alessandro Narducci, Deborah M Eastwood, Maureen Cleary, Dominic Thompson
STUDY DESIGN: Retrospective case series OBJECTIVE.: To review clinical and radiological outcomes of craniovertebral surgery in children with Morquio A syndrome (Mucopolysaccharidosis type IVA) and develop an evidence-based management algorithm. SUMMARY OF BACKGROUND DATA: Myelopathy secondary to craniovertebral pathology is a common cause of neurological disability in Morquio A syndrome. Previously unresolved surgical controversies include the value of surveillance, surgical indications and operative technique...
June 12, 2018: Spine
https://www.readbyqxmd.com/read/29901178/mir%C3%A2-150-promotes-the-proliferation-and-migration-of-non%C3%A2-small-cell-lung-cancer-cells-by-regulating-the-sirt2-jmjd2a-signaling-pathway
#15
Kanqiu Jiang, Mingjing Shen, Yongbing Chen, Weihua Xu
Lung cancer (LC), as the most common cause of cancer‑related mortality worldwide, is characterized by difficulties in early detection, a high degree of malignancy, poor sensitivity to radiotherapy and chemotherapy, and a low 5‑year survival rate. MicroRNA (miRNA) is a class of small, non‑coding, endogenously expressed RNA that serves vital roles in RNA silencing and post‑transcriptional regulation of gene expression. Previous studies have shown that abnormal expression of miRNA is relevant to various malignant tumors, including lung cancer...
June 12, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29898749/media-devices-in-pre-school-children-the-recommendations-of-the-italian-pediatric-society
#16
Elena Bozzola, Giulia Spina, Margherita Ruggiero, Luigi Memo, Rino Agostiniani, Mauro Bozzola, Giovanni Corsello, Alberto Villani
BACKGROUND: Young children are too often exposed to mobile devices (MD) and most of them had their own device. The adverse effects of a early and prolonged exposure to digital technology on pre-school children has been described by several studies. Aim of the study is to analyze the consequences of MD exposure in pre-school children. METHODS: We analyzed the documented effects of media exposure on children's mental and physical health. RESULTS: According to recent studies, MD may interfere with learning, children development, well being, sleep, sight, listening, caregiver-child relationship...
June 14, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29897169/what-is-a-maison-des-adolescents-a-history-of-integrated-youth-health-care-services-in-france
#17
Laelia Benoit, Patrick Cottin, Marie R Moro
AIM: Since 1999, the development of more than 100 "Maisons des Adolescents" (MDAs) has enabled young persons to gain access to specific care in integrated youth-friendly facilities in France. To contribute to the development and standardization of international youth-friendly health care services, this review provides insight into the French MDA facilities. METHODS: This socio-historical analysis includes a systematic review of articles referring to the MDAs (selection through title and/or abstract), ministry reports and newspaper articles, from 1999 to 2018...
June 13, 2018: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29895627/sub-acute-leaflet-thrombosis-a-reversible-cause-of-aortic-stenosis
#18
Athina Chasapi, Adam Hobbs, Theodore Velissaris, Benoy N Shah
A 77 year old male underwent elective bioprosthetic aortic valve replacement (23mm Carpentier-Edwards Perimount MagnaEase) for severe aortic stenosis. His pre-discharge transthoracic echocardiogram (TTE) was normal. He presented 9 days after surgery with dyspnoea and fever. He was in sinus rhythm. Blood cultures were taken and he was commenced on empirical antibiotics for possible infective endocarditis (subsequently all negative). Repeat TTE showed a well-seated prosthesis without regurgitation but elevated gradients (peak / mean gradients 49 / 22 mmHg respectively)...
June 12, 2018: Echo Research and Practice
https://www.readbyqxmd.com/read/29894456/objective-assessment-of-lingual-nerve-microsurgical-reconstruction
#19
Federico Biglioli, Alessandro Lozza, Giacomo Colletti, Fabiana Allevi
Lingual nerve (LN) injury is one of the most serious consequences of oral surgery. Prompt microsurgical reconstruction of the nerve can alleviate most of those symptoms leading to satisfactory functional recovery.Thirty-five patients with partial to complete LN injury underwent surgery in the period between January 2006 and May 2015. All patients underwent a preoperative clinical and neurological evaluation with the assessment of lingual tactile and pain sensory thresholds and masseteric inhibitory reflex.All patients underwent explorative surgery and direct microneurorrhaphy of distal and proximal stumps in case of complete lesion, while the removal of traumatic neuroma and the following microneurorrhaphy of distal and proximal stumps of the injured nerve was performed in case of incomplete lesion...
June 11, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29892929/effect-of-early-mobilization-on-postoperative-pulmonary-complications-in-patients-undergoing-video-assisted-thoracoscopic-surgery-on-the-esophagus
#20
Masatoshi Hanada, Kengo Kanetaka, Shigekazu Hidaka, Ken Taniguchi, Masato Oikawa, Shuntaro Sato, Susumu Eguchi, Ryo Kozu
BACKGROUND: Esophagectomy performed via thoracotomy is associated with a high rate of postoperative pulmonary complications. Video-assisted thoracoscopic surgery at the esophagus (VATS-E) can reduce the rate of postoperative pulmonary complications. VATS-E is being increasingly implemented owing to its benefits. This procedure makes early patient mobilization possible, because there is minimal thoracic wall invasion, and thus, less postoperative pain. This study aimed to identify the efficacy of early mobilization in patients undergoing VATS-E...
April 2018: Esophagus: Official Journal of the Japan Esophageal Society
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