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https://www.readbyqxmd.com/read/27933715/efficacy-of-self-monitoring-of-blood-glucose-versus-retrospective-continuous-glucose-monitoring-in-improving-glycaemic-control-in-diabetic-kidney-disease-patients
#1
Ester Chai Kheng Yeoh, Boon Khim Lim, Sharon Fun, Julia Tong, Lee Ying Yeoh, Chee Fang Sum, Tavintharan Subramaniam, Su Chi Lim
AIMS: Patients with diabetic kidney disease (DKD) on anti-diabetic agents, are at greater risk of glycemic variations, both hypoglycemia and hyperglycemia. We aimed to compare glycemic control (using HbA1c) and hypoglycemia incidence in patients with Stage 3 DKD (eGFR 30-60 ml/min/1.73 m(2) ), receiving retrospective CGM-guided anti-diabetic therapy versus self-monitoring of blood glucose (SMBG) over 3 months. METHODS: Thirty patients with HbA1c > 8% were randomized to 6-day retrospective CGM or SMBG...
December 9, 2016: Nephrology
https://www.readbyqxmd.com/read/27933671/causal-inference-in-obesity-research
#2
REVIEW
P W Franks, N Atabaki-Pasdar
Obesity is a risk factor for a plethora of severe morbidities and premature death. Most supporting evidence comes from observational studies that are prone to chance, bias and confounding. Even data on the protective effects of weight loss from randomized controlled trials will be susceptible to confounding and bias if treatment assignment cannot be masked, which is usually the case with lifestyle and surgical interventions. Thus, whilst obesity is widely considered the major modifiable risk factor for many chronic diseases, its causes and consequences are often difficult to determine...
December 8, 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27933415/association-between-gamma-glutamyltransferase-and-albuminuria-in-nondiabetic-adults-with-normal-renal-function
#3
Sun-Hye Ko, Myong Ki Baeg, Kyung-Do Han, Seung-Yeon Ko, Sae-Bom Shin, Seung-Hyun Ko, Yu-Bae Ahn
BACKGROUND: Serum gamma-glutamyltransferase (GGT) has been associated with albuminuria in diabetes patients, but it has not been investigated in the general population. We aimed to investigate the association between serum GGT and albuminuria in the nondiabetic Korean population with normal kidney function. METHODS: Study participants (3948; 1549 men and 2399 women) with an estimated glomerular filtration rate ≥60 mL/min/1.73 m(2) were analyzed from the fifth Korean National Health and Nutrition Examination Survey (2011)...
December 9, 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/27932514/long-term-therapy-with-wu-ling-san-a-popular-antilithic-chinese-herbal-formula-did-not-prevent-subsequent-stone-surgery-a-nationwide-population-based-cohort-study
#4
San-Yuan Wu, Huey-Yi Chen, Kao-Sung Tsai, Jen-Huai Chiang, Chih-Hsin Muo, Fung-Chang Sung, Yung-Hsiang Chen, Wen-Chi Chen
Traditional Chinese herbal medicine (CHM), which is widely used to treat pain and urolithiasis, is a promising therapy for urinary stone prevention. This study investigated the clinical efficacy of a popular CHM, Wu-Ling-San (WLS), in Taiwan for the prophylaxis of recurrent nephrolithiasis as assessed by surgical stone treatment via a nationwide population-based cohort study. The National Health Insurance Research Database, 2000-2010, which included one million patient records. All patients diagnosed with stone disease at the beginning of the study...
2016: Inquiry: a Journal of Medical Care Organization, Provision and Financing
https://www.readbyqxmd.com/read/27932140/influence-of-donor-and-recipient-ages-in-survival-of-simultaneous-pancreas-kidney-transplantation
#5
A J Arenas-Bonilla, J P Campos-Hernández, J Carrasco-Valiente, F J Márquez-López, J M Ruiz-García, A Sánchez-Gónzalez, J J Salamanca-Bustos, J C Regueiro-López, M D Navarro-Cabello, M J Requena-Tapia
INTRODUCTION: Simultaneous pancreas-kidney transplantation (SPKT) is a well treatment for patients with insulin-dependent diabetes and end-stage renal disease. Donor age is a barrier to the acceptance of organs. Age matching has been extensively studied in kidney transplantation; however, there are no studies in graft survival after SPKT. We aimed to study the combined influence of the ages of the donors and recipients in graft survival after SPKT. MATERIAL AND METHODS: Donors and recipients are classified as younger (age <40 years) or older (age ≥40 years)...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27932113/hepatitis-c-treatment-with-direct-acting-antivirals-in-kidney-transplant-preliminary-results-from-a-multicenter-study
#6
M A Gentil, C González-Corvillo, M Perelló, S Zarraga, C Jiménez-Martín, L R Lauzurica, A Alonso, A Franco, D Hernández-Marrero, A Sánchez-Fructuoso
Hepatitis C (HC) is a very relevant negative prognosis factor for graft and transplant recipient survival. New direct-acting antivirals (DAAs) allow us to solve this problem in an effective way. It is crucial to understand their real impact in our daily practice. We analyzed treatment results with DAA, free of interferon, in kidney transplant recipients (KTRs) from 15 Spanish hospitals (Grupo Español de Actualización en Trasplante), regarding effectiveness, tolerance, and impact on immunosuppression, renal function-proteinuria, and diabetes...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27932098/urinary-clara-cell-protein-in-kidney-transplant-patients-a-preliminary-study
#7
P M García-García, E Martín-Izquierdo, C M-F de Basoa, A Jarque-López, G Pérez-Suárez, A Rivero-González, J M González-Posadas, M Macía-Heras, V M García-Nieto, J F Navarro-Gónzález
OBJECTIVE: The aim of this exploratory study was to analyze the urinary excretion of Clara cell protein (CC16), a new marker of proximal tubular dysfunction (PTD), in kidney transplantation (KT). MATERIALS AND METHODS: Urinary concentrations of CC16, β2-microglobulin (β2m), and N-acetyl-glucosaminidase (NAG) were measured in 50 KT patients (72% men; mean age 50.4 ± 12.4 years; diabetes in 24%; duration of KT 4.3 ± 3.1 years) and 10 healthy controls (6 men; mean age 33...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27931726/meta-analysis-of-impact-of-diabetes-mellitus-on-outcomes-after-transcatheter-aortic-valve-implantation
#8
Yinghao Sun, Xianbao Liu, Yuxin He, Mengyao Tang, Qifeng Zhu, Xiaobin Xu, Dongyu Guo, Keda Shi, Po Hu, Lihan Wang, Huijia Kong, Jubo Jiang, Xiaoping Lin, Qiyuan Xu, Feng Gao, Jian'an Wang
To date, the impact of diabetes mellitus (DM) on prognosis after transcatheter aortic valve implantation (TAVI) is still contradictory and thus merits further investigation. The purpose of this meta-analysis was to evaluate the impact of DM on outcomes after TAVI. A systematic search of the PubMed database was performed. Primary end points were 30-day and 1-year all-cause mortality after TAVI. Risk ratios (RRs) and 95% CIs were calculated using the random-effect or fixed-effect model, depending on heterogeneity between studies, and p values <0...
November 16, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27931572/pretransplantation-risk-factors-associated-with-new-onset-diabetes-after-living-donor-kidney-transplantation
#9
L Xie, W Tang, X Wang, L Wang, Y Lu, T Lin
Mid-term date of kidney recipients with new-onset diabetes mellitus after transplantation (NODAT) was poor. We made a retrospective study of 397 patients who had living-donor kidney transplantation between January 2007 and May 2010 in our center. Pretransplantation risk factors for NODAT were identified by univariate and multivariate analyses. The mean follow-up was 53.5 ± 10.4 months. The prevalence of NODAT was 9.3%. Univariate analyses found the mean recipient age ≥40 years, body mass index (BMI) ≥24 kg/m(2), family history of diabetes, fasting blood glucose (FBG) ≥5...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27931571/incidence-of-diabetes-mellitus-after-kidney-transplantation-in-slovakia-multicentric-prospective-analysis
#10
L Dedinská, T Baltesová, Ĺ Beňa, M Čellár, P Galajda, M Chrastina, A Jurčina, L Kováčiková, L Laca, E Lacková, S Lauková Valachová, J Miklušica, J Rosenberger, M Sersenová, P Skalová, Z Žilinská, M Mokáň
BACKGROUND: The incidence rate of post-transplant diabetes mellitus (PTDM) after kidney transplantation (KT) is 5% to 40%. The objective of this analysis was to identify the risk factors of PTDM after KT in the Slovak Republic (SR). METHODS: In the group of 133 patients/non-diabetics, we identified the risk factors of PTDM in the monitored period of 12 months from transplantation. RESULTS: The incidence of PTDM in the SR in 2014 was 38.3%...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27931015/the-association-of-vitamin-d-status-and-vitamin-d-replacement-therapy-to-glycemic-control-serum-uric-acid-levels-and-microalbuminuria-among-patients-with-type-2-diabetes-with-chronic-kidney-disease
#11
Savas Sipahi, Seyyid Bilal Acikgoz, Ahmet Bilal Genc, Mehmet Yildirim, Yalcin Solak, Ali Tamer
No abstract text is available yet for this article.
December 6, 2016: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/27930696/risk-factors-for-incidence-of-cardiovascular-diseases-and-all-cause-mortality-in-a-middle-eastern-population-over-a-decade-follow-up-tehran-lipid-and-glucose-study
#12
Mahsa Sardarinia, Samaneh Akbarpour, Mojtaba Lotfaliany, Farideh Bagherzadeh-Khiabani, Mohammadreza Bozorgmanesh, Farhad Sheikholeslami, Fereidoun Azizi, Farzad Hadaegh
BACKGROUND: To examine the association between potentially modifiable risk factors with cardiovascular disease (CVD) and all-cause mortality and to quantify their population attributable fractions (PAFs) among a sample of Tehran residents. METHODS: Overall, 8108 participants (3686 men) aged≥30 years, were investigated. To examine the association between risk factors and outcomes, multivariate sex-adjusted Cox proportional hazard regression analysis were conducted, using age as time-scale in two models including general/central adiposity: 1)adjusted for different independent variables including smoking, education, family history of CVD and sex for both outcomes and additionally adjusted for prevalent CVD for all-cause mortality 2)further adjusted for obesity mediators (hypertension, diabetes, lipid profile and chronic kidney disease)...
2016: PloS One
https://www.readbyqxmd.com/read/27928774/a-3d-printed-anatomical-pancreas-and-kidney-phantom-for-optimizing-spect-ct-reconstruction-settings-in-beta-cell-imaging-using-111-in-exendin
#13
Wietske Woliner-van der Weg, Laura N Deden, Antoi P W Meeuwis, Maaike Koenrades, Laura H C Peeters, Henny Kuipers, Geert Jan Laanstra, Martin Gotthardt, Cornelis H Slump, Eric P Visser
BACKGROUND: Quantitative single photon emission computed tomography (SPECT) is challenging, especially for pancreatic beta cell imaging with (111)In-exendin due to high uptake in the kidneys versus much lower uptake in the nearby pancreas. Therefore, we designed a three-dimensionally (3D) printed phantom representing the pancreas and kidneys to mimic the human situation in beta cell imaging. The phantom was used to assess the effect of different reconstruction settings on the quantification of the pancreas uptake for two different, commercially available software packages...
December 2016: EJNMMI Physics
https://www.readbyqxmd.com/read/27928640/diabetes-as-a-risk-factor-in-patients-undergoing-groin-hernia-surgery
#14
Gustaf Hellspong, Ulf Gunnarsson, Ursula Dahlstrand, Gabriel Sandblom
BACKGROUND: Diabetes is a known risk factor for early postoperative complications. Even so, the incidence of acute postoperative complications following routine hernia surgery is seldom described, and the risk for reoperation for recurrence has hardly been studied. Our aim was to explore if diabetes is a significant risk factor for complications after inguinal hernia surgery. METHODS: All inguinal hernia repairs registered in the Swedish Hernia Register between 2002 and 2011 were identified...
December 7, 2016: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/27927859/systemic-elevation-of-proinflammatory-interleukin-18-in-hiv-hcv-coinfection-versus-hiv-or-hcv-monoinfection
#15
Rebecca T Veenhuis, Jacquie Astemborski, Michael A Chattergoon, Paige Greenwood, Marissa Jarosinski, Richard D Moore, Shruti H Mehta, Andrea L Cox
BACKGROUND: HIV/HCV coinfection and elevated interleukin (IL)-18 levels are both associated with enhanced progression of hepatic inflammation and increased risk of diabetes, kidney disease, and cardiovascular disease. IL-18 is a proinflammatory cytokine made upon activation of the inflammasome, an innate sensing system. We assessed whether increased IL-18 could explain the increased incidence and progression of inflammatory conditions seen with HIV/HCV coinfection. METHODS: Serum from 559 subjects with HIV monoinfection, HCV monoinfection, HIV/HCV coinfection, or people who inject drugs with neither infection was tested for IL-18 by ELISA and for 16 other analytes by electrochemiluminescence immunoassay...
December 7, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27927650/cellular-transport-of-l-arginine-determines-renal-medullary-blood-flow-in-control-rats-but-not-in-diabetic-rats-despite-enhanced-cellular-uptake-capacity
#16
Patrik Persson, Angelica Fasching, Tom Teerlink, Peter Hansell, Fredrik Palm
Diabetes mellitus is associated with decreased nitric oxide bioavailability thereby affecting renal blood flow regulation. Previous reports have demonstrated that cellular uptake of L-arginine is rate limiting for nitric oxide production, and that plasma L-arginine concentration is decreased in diabetes. We therefore investigated if regional renal blood flow regulation is affected by cellular L-arginine uptake in streptozotocin-induced diabetic rats. Rats were anesthetized with thiobutabarbital and left kidney was exposed...
December 7, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27927599/angiotensin-converting-enzyme-2-amplification-limited-to-the-circulation-does-not-protect-mice-from-development-of-diabetic-nephropathy
#17
Jan Wysocki, Minghao Ye, Ahmed M Khattab, Agnes Fogo, Aline Martin, Nicolae Valentin David, Yashpal Kanwar, Mark Osborn, Daniel Batlle
Blockers of the renin-angiotensin system are effective in the treatment of experimental and clinical diabetic nephropathy. An approach different from blocking the formation or action of angiotensin II (1-8) that could also be effective involves fostering its degradation. Angiotensin-converting enzyme 2 (ACE2) is a monocarboxypeptidase that cleaves angiotensin II (1-8) to form angiotensin (1-7). Therefore, we examined the renal effects of murine recombinant ACE2 in mice with streptozotocin-induced diabetic nephropathy as well as that of amplification of circulating ACE2 using minicircle DNA delivery prior to induction of experimental diabetes...
December 4, 2016: Kidney International
https://www.readbyqxmd.com/read/27927597/albuminuria-changes-are-associated-with-subsequent-risk-of-end-stage-renal-disease-and%C3%A2-mortality
#18
Juan Jesús Carrero, Morgan E Grams, Yingying Sang, Johan Ärnlöv, Alessandro Gasparini, Kunihiro Matsushita, Abdul R Qureshi, Marie Evans, Peter Barany, Bengt Lindholm, Shoshana H Ballew, Andrew S Levey, Ron T Gansevoort, Carl G Elinder, Josef Coresh
Current guidelines for chronic kidney disease (CKD) recommend using albuminuria as well as estimated glomerular filtration rate (eGFR) to stage CKD. However, CKD progression is solely defined by change in eGFR with little regard to the risk implications of change in albuminuria. This is an observational study from the Stockholm CREAtinine Measurements (SCREAM) project, a health care utilization cohort from Stockholm, Sweden, with laboratory measures from 2006-2011 and follow-up through December 2012. Included were 31,732 individuals with two or more ambulatory urine albumin to creatinine ratio (ACR) tests...
December 4, 2016: Kidney International
https://www.readbyqxmd.com/read/27927587/estimated-gfr-before-and-after-bariatric-surgery-in-ckd
#19
Talha H Imam, Heidi Fischer, Bocheng Jing, Raoul Burchette, Shayna Henry, Stephen F DeRose, Karen J Coleman
BACKGROUND: Several reviews have recently detailed the beneficial effects of weight loss surgery for kidney function. However, these studies have a number of limitations, including small sample size, few done in chronic kidney disease (CKD) stages 3 and 4, and many not including the main bariatric surgery procedures used in the United States today. STUDY DESIGN: This was an observational retrospective cohort study comparing propensity score-matched bariatric surgery patients and nonsurgery control patients who were referred for, but did not have, surgery...
December 4, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27925659/impaired-left-atrial-conduit-function-in-coronary-artery-disease-patients-with-poorly-controlled-diabetes-two-dimensional-speckle-tracking-echocardiographic-study
#20
Ali Hosseinsabet, Reza Mohseni-Badalabadi, Ali Moinfar
OBJECTIVES: The myocardium can be affected by diabetes mellitus. The effects of blood glucose control on some organs such as the kidney and eye have been previously reported. The aim of our study was to evaluate left atrial function via 2-dimensional (2D) speckle-tracking echocardiography in a group of coronary artery disease (CAD) patients with well-controlled diabetes (hemoglobin A1c [HbA1c] < 7%) and to compare it with that in a group of CAD patients with poorly controlled diabetes...
November 28, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
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