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https://www.readbyqxmd.com/read/28209808/galactosylation-of-iga1-is-associated-with-common-variation-in-c1galt1
#1
Daniel P Gale, Karen Molyneux, David Wimbury, Patricia Higgins, Adam P Levine, Ben Caplin, Anna Ferlin, Peiran Yin, Christopher P Nelson, Horia Stanescu, Nilesh J Samani, Robert Kleta, Xueqing Yu, Jonathan Barratt
IgA nephropathy (IgAN), an important cause of kidney failure, is characterized by glomerular IgA deposition and is associated with changes in O-glycosylation of the IgA1 molecule. Here, we sought to identify genetic factors contributing to levels of galactose-deficient IgA1 (Gd-IgA1) in white and Chinese populations. Gd-IgA1 levels were elevated in IgAN patients compared with ethnically matched healthy subjects and correlated with evidence of disease progression. White patients with IgAN exhibited significantly higher Gd-IgA1 levels than did Chinese patients...
February 16, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28207635/kidney-transplantation-rates-across-glomerulonephritis-subtypes-in-the-united-states
#2
Michelle M O'Shaughnessy, Sai Liu, Maria E Montez-Rath, Richard A Lafayette, Wolfgang C Winkelmayer
BACKGROUND: Whether kidney transplantation rates differ by glomerulonephritis (GN) subtype remains largely unknown. METHODS: Using the US Renal Data System, we identified all adult patients with ESRD attributed to 1 of 6 GN subtypes who initiated dialysis in the US (1996-2013). Patients with diabetic nephropathy (DN) and autosomal-dominant polycystic kidney disease (ADPKD) served as "external" non-GN comparators. Using Cox proportional hazards regression, with death considered a competing risk, we estimated hazard ratios [HRs (95% confidence intervals)] for first kidney transplantation, controlling for year, demographics, comorbidities, socioeconomic factors, and Organ Procurement Organization (OPO)...
February 15, 2017: Transplantation
https://www.readbyqxmd.com/read/28187233/a-comparison-of-cystatin-c-concentrations-between-patients-with-chronic-interstitial-nephritis-and-glomerular-diseases
#3
Nicolas Roberto Robles, Candido Mena, Edgar Chavez, Miguel Angel Bayo, Boris Gonzalez Candia, Antonio Cidoncha, Juan Lopez Gomez, Juan Jose Cubero
AIMS: Cystatin C have shown to be a renal function parameter with higher sensitivity and specificity than serum creatinine. In tubular diseases, cystatin C degradation and an increase in its urinary elimination would be observed. We have tried to define if different kinds of kidney diseases may significantly affect the serum levels of cystatin C. DESIGN AND METHODS: Four hundred and four patients were studied: 249 men and 155 women, mean age was 64.3±10.1 years...
February 10, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28186167/in-vivo-pharmacological-evaluations-of-pilocarpine-loaded-antioxidant-functionalized-biodegradable-thermogels-in-glaucomatous-rabbits
#4
Shih-Feng Chou, Li-Jyuan Luo, Jui-Yang Lai
To alleviate oxidative stress-induced ocular hypertension, grafting of antioxidant molecules to drug carriers enables a dual-function mechanism to effectively treat glaucomatous intraocular pressure (IOP) dysregulation. Providing potential application for intracameral administration of antiglaucoma medications, this study, for the first time, aims to examine in vivo pharmacological efficacy of pilocarpine-loaded antioxidant-functionalized biodegradable thermogels in glaucomatous rabbits. A series of gallic acid (GA)-grafted gelatin-g-poly(N-isopropylacrylamide) (GN) polymers were synthesized via redox reactions at 20-50 °C...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28169520/hydrogen-gas-recycling-for-energy-efficient-ammonia-recovery-in-electrochemical-systems
#5
Philipp Kuntke, Mariana Rodriguez Arredondo, Laksminarastri Widyakristi, Annemiek Ter Heijne, Tom H J A Sleutels, Hubertus V M Hamelers, Cees J N Buisman
Recycling of hydrogen gas (H2) produced at the cathode to the anode in an electrochemical system allows for energy efficient TAN (Total Ammonia Nitrogen) recovery. Using a H2 recycling electrochemical system (HRES) we achieved high TAN transport rates at low energy input. At a current density of 20 A m(-2), TAN removal rate from the influent was 151 gN m(-2) d(-1) at an energy demand of 26.1 kJ gN-1. The maximum TAN transport rate of 335 gN m(-2) d(-1) was achieved at a current density of 50 A m(-2) and an energy demand of 56...
February 7, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28157959/optimal-fiber-design-for-large-capacity-long-haul-coherent-transmission-invited
#6
Takemi Hasegawa, Yoshinori Yamamoto, Masaaki Hirano
Fiber figure of merit (FOM), derived from the GN-model theory and validated by several experiments, can predict improvement in OSNR or transmission distance using advanced fibers. We review the FOM theory and present design results of optimal fiber for large capacity long haul transmission, showing variation in design results according to system configuration.
January 23, 2017: Optics Express
https://www.readbyqxmd.com/read/28148558/risk-factors-for-renal-survival-in-chinese-patients-with-myeloperoxidase-anca-associated-gn
#7
Yinghua Chen, Hao Bao, Zhengzhao Liu, Xia Liu, Erzhi Gao, Caihong Zeng, Haitao Zhang, Zhihong Liu, Weixin Hu
BACKGROUND AND OBJECTIVES: Our study explored the association of histopathologic classification of ANCA-associated GN with renal survival in Chinese patients with myeloperoxidase-ANCA-associated GN. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Two hundred fifteen patients with biopsy-proven myeloperoxidase-ANCA-associated GN were included from January of 1996 to December of 2014. The biopsies included focal (n=27), mixed (n=82), crescentic (n=47), and sclerotic (n=59) classes...
February 1, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28148248/effect-of-removable-functional-appliances-on-mandibular-length-in-patients-with-class-ii-with-retrognathism-systematic-review-and-meta-analysis
#8
Adriana Santamaría-Villegas, Rubén Manrique-Hernandez, Emery Alvarez-Varela, Claudia Restrepo-Serna
BACKGROUND: Orthopedic functional devices, are used to improve mandibular length in skeletal class II patients. However, the orthopedic functional device with the best effect to increasing the mandibular length, has not been identified before. Thus, the aim of the present investigation was to evaluate Randomized Controlled Trials (RCT), to determine the best functional appliance improving mandibular length in subjects with retrognathism. METHODS: A systematic review and meta-analysis was performed, including studies published and indexed in databases between 1966 and 2016...
February 1, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28147348/the-association-between-biomarker-profiles-etiology-of-chronic-kidney-disease-and-mortality
#9
David Langsford, Mila Tang, Hicham I Cheikh Hassan, Ognjenka Djurdjev, Manish M Sood, Adeera Levin
BACKGROUND: Prognosis in chronic kidney disease (CKD) for adverse outcomes differs substantially based on the etiology of CKD. We examined whether the biomarker profile differed based on CKD etiology and whether they were associated with mortality. METHODS: Prospective observational study of 1,157 patients, 663 with diabetic kidney disease (DKD), 273 with glomerulonephritis (GN), and 221 with cystic/interstitial disease (polycystic kidney disease, pyelonephritis or chronic tubulointerstitial nephritis [PCK/TIN]) were identified in the Canadian Study of Prediction of Dialysis, Death and Interim Cardiovascular events over Time cohort...
February 2, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28135876/analysis-of-the-association-between-mycobacterium-tuberculosis-infection-and-immunoglobulin-a-nephropathy-by-early-secreted-antigenic-target-6-detection-in-renal-biopsies-a-prospective-study
#10
Sun Li, Teng Siyuan, Feng Jiangmin, Wang Hailong, Yao Li, Ma Jianfei, Wang Lining
OBJECTIVES: Immunoglobulin A nephropathy (IgAN) is the most frequent cause of primary renal disease, and clarifying the pathogenesis of IgAN is of great importance for its diagnosis and treatment. It is well known that Mycobacterium tuberculosis (MTB) can infect the urinary tract and result in the typical symptoms of cystitis. However, MTB can also affect the kidney more insidiously. Patients may present with glomerular disease, and sometimes with advanced renal failure. This study was to investigate the association between MTB infection and IgA nephropathy (IgAN), and the early diagnosis of MTB-mediated IgAN by means of early secreted antigenic target 6 (ESAT-6) detection in renal biopsies...
January 30, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28133089/-strategy-for-unresectable-pancreatic-cancer-with-stenosis-of-the-duodenum-a-case-report
#11
Masahiko Komagome, Riki Ninomiya, Akiko Nakazawa, Tetsuya Mitsui, Akira Maki, Fumiaki Ozawa, Yoshifumi Beck
Unresectable(UR)pancreatic cancer often causes duodenal obstruction. Case 1: A 58-year-old man was diagnosed with UR pancreatic cancer with obstruction of the 3rd duodenal portion. A duodenum 2nd portion jejunum bypass was performed, and FOLFIRINOX was introduced and continued over 6 months. Case 2: A 74-year-old man was diagnosed with UR pancreatic cancer with obstruction of the duodenum near the Treitz ligament. A duodenum 3rd portion jejunum bypass was performed, and gemcitabine plus nab-paclitaxel was introduced...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28131612/associations-between-occlusion-jaw-relationships-craniofacial-dimensions-and-the-occurrence-of-palatally-displaced-canines
#12
Fariborz Amini, Shayesteh Hamedi, Mona Haji Ghadimi, Vahid Rakhshan
BACKGROUND AND PURPOSE: Cephalometric and arch measurements might predict the occurrence of a palatally-displaced impacted maxillary canine (PDC). Despite their clinical importance, studies in this regard are limited and controversial. METHODS: In this case-control study, 35 PDC patients and 77 controls aged over 13 years were examined. Eleven cephalometric measurements: N-S, ANS-PNS, ANS-N, S-N-ANS, facial angle (FH/NPog), SNA, SNB, Y-axis (SN/SGn), gonial angle, Go-Gn/SN, and Jarabak Index were performed...
January 25, 2017: International Orthodontics
https://www.readbyqxmd.com/read/28125774/one-pot-synthesis-of-fe3o4-nanoparticle-loaded-3d-porous-graphene-nanocomposites-with-enhanced-nanozyme-activity-for-glucose-detection
#13
Qingqing Wang, Xueping Zhang, Liang Huang, Zhiquan Zhang, Shaojun Dong
A novel one-pot strategy is proposed to fabricate 3D porous graphene (3D GN) decorated with Fe3O4 nanoparticles (Fe3O4 NPs) by using hemin as iron source. During the process, graphene oxide was simultaneously reduced and self-assembled to form 3D graphene hydrogel while Fe3O4 NPs synthetized from hemin distributed uniformly on 3D GN. The preparation process is simple, facile, economical and green. The obtained freeze-dried product (3D GH-5) exhibits outstanding peroxidase-like activity. Compared to the traditional 2D graphene-based nanocomposites, the introduced 3D porous structure dramatically improved the catalytic activity, as well as the catalysis velocity and its affinity for substrate...
January 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28122569/appearance-of-renal-hemorrhage-in-adult-mice-after-inoculation-of-patient-derived-hantavirus
#14
Kenta Shimizu, Takaaki Koma, Kumiko Yoshimatsu, Yoshimi Tsuda, Yuji Isegawa, Jiro Arikawa
BACKGROUND: Hemorrhagic fever with renal syndrome (HFRS) caused by hantavirus infection is characterized by fever, renal dysfunction and hemorrhage. An animal model mimicking symptoms of HFRS remains to be established. In this study, we evaluated the pathogenicity of an HFRS patient-derived Hantaan virus (HTNV) in adult mice. METHODS: Five clones of HTNV strain KHF 83-61 BL (KHFV) that was derived from blood of an HFRS patient were obtained by plaque cloning. The pathogenicity of the virus clones was evaluated by using 6-week-old female BALB/c mice...
January 26, 2017: Virology Journal
https://www.readbyqxmd.com/read/28118988/evaluation-of-positive-rift-valley-fever-virus-formalin-fixed-paraffin-embedded-samples-as-a-source-of-sequence-data-for-retrospective-phylogenetic-analysis
#15
B Mubemba, P N Thompson, L Odendaal, P Coetzee, E H Venter
Rift Valley fever (RVF), caused by an arthropod borne Phlebovirus in the family Bunyaviridae, is a haemorrhagic disease that affects ruminants and humans. Due to the zoonotic nature of the virus, a biosafety level 3 laboratory is required for isolation of the virus. Fresh and frozen samples are the preferred sample type for isolation and acquisition of sequence data. However, these samples are scarce in addition to posing a health risk to laboratory personnel. Archived formalin-fixed, paraffin-embedded (FFPE) tissue samples are safe and readily available, however FFPE derived RNA is in most cases degraded and cross-linked in peptide bonds and it is unknown whether the sample type would be suitable as reference material for retrospective phylogenetic studies...
January 22, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28117305/dose-dependent-cytotoxicity-evaluation-of-graphite-nanoparticles-for-diamond-like-carbon-film-application-on-artificial-joints
#16
T T Liao, Q Y Deng, B J Wu, S S Li, X Li, J Wu, Y X Leng, Y B Guo, N Huang
While a diamond-like carbon (DLC)-coated joint prosthesis represents the implant of choice for total hip replacement in patients, it also leads to concern due to the cytotoxicity of wear debris in the form of graphite nanoparticles (GNs), ultimately limiting its clinical use. In this study, the cytotoxicity of various GN doses was evaluated. Mouse macrophages and osteoblasts were incubated with GNs (<30 nm diameter), followed by evaluation of cytotoxicity by means of assessing inflammatory cytokines, results of alkaline phosphatase assays, and related signaling protein expression...
January 24, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28116900/interface-polarization-strategy-to-solve-electromagnetic-wave-interference-issue
#17
Hualiang Lv, Yuhang Guo, Guanglei Wu, Guangbin Ji, Yue Zhao, Zhichuan J Xu
Design of an interface to arouse interface polarization is an efficient route to attenuate high-frequency electromagnetic waves. The attenuation intensity is highly related to the contact area. To achieve stronger interface polarization, growing metal oxide granular film on graphene with a larger surface area seems to be an efficient strategy due to the high charge carrier concentration of graphene. This study is devoted to fabricating the filmlike composite by a facile thermal decomposition method and investigating the relationship among contact area, polarization intensity, and the type of metal oxide...
February 2, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28112665/modeling-the-ph-effects-on-nitrogen-removal-in-the-anammox-enriched-granular-sludge
#18
Xi Lu, Zhixuan Yin, Dominika Sobotka, Kamil Wisniewski, Krzysztof Czerwionka, Li Xie, Qi Zhou, Jacek Makinia
The aim of the study was to determine the pH effects on nitrogen removal in the anammox-enriched granular sludge. The experimental data were extracted from a 4 L completely-mixed batch reactor with the granular sludge at different initial pH values (6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, 10, 10.5) and constant temperature T = 30 °C. Simulations were run in GPS-X 6.4 using a comprehensive mechanistic model Mantis2. Two kinetic parameters, the maximum specific growth rates of ammonia oxidizing bacteria (AOB) and anammox bacteria, were optimized at different pH scenarios...
January 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28111009/glomerular-common-gamma-chain-confers-b-and-t-cell-independent-protection-against-glomerulonephritis
#19
Yosu Luque, Dominique Cathelin, Sophie Vandermeersch, Xiaoli Xu, Julie Sohier, Sandrine Placier, Yi-Chun Xu-Dubois, Kevin Louis, Alexandre Hertig, Jean-Christophe Bories, Florence Vasseur, Fabien Campagne, James P Di Santo, Christian Vosshenrich, Eric Rondeau, Laurent Mesnard
Crescentic glomerulonephritis is a life-threatening renal disease that has been extensively studied by the experimental anti-glomerular basement membrane glomerulonephritis (anti-GBM-GN) model. Although T cells have a significant role in this model, athymic/nude mice and rats still develop severe renal disease. Here we further explored the contribution of intrinsic renal cells in the development of T-cell-independent GN lesions. Anti-GBM-GN was induced in three strains of immune-deficient mice (Rag2(-/-), Rag2(-/-)Il2rg(-/-), and Rag2(-/-)Il2rb(-/-)) that are devoid of either T/B cells or T/B/NK cells...
January 19, 2017: Kidney International
https://www.readbyqxmd.com/read/28104519/load-ratio-determines-the-ammonia-recovery-and-energy-input-of-an-electrochemical-system
#20
Mariana Rodríguez Arredondo, Philipp Kuntke, Annemiek Ter Heijne, Hubertus V M Hamelers, Cees J N Buisman
Complete removal and recovery of total ammonia nitrogen (TAN) from wastewaters in (bio)electrochemical systems has proven to be a challenge. The system performance depends on several factors, such as current density, TAN loading rate and pH. The interdependence among these factors is not well understood yet: insight is needed to achieve maximum ammonium recovery at minimal energy input. The aim of this study was to investigate the influence of current density and TAN loading rate on the recovery efficiency and energy input of an electrochemical cell (EC)...
December 31, 2016: Water Research
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