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Chen-Fei Shen, Zi-Zhong Liu, Hong-Xia Liu, Hui-Qing Zhang
A new method to measure the amount of aromaticity is presented through the process of Bond Length Equalization (BLE). Degree of Aromaticity (DOA), a two-dimensional intensive quantity including geometric and energetic factors, as a new measurement of aromaticity is proposed. The unique characteristic of DOA and the formation of DOA will be displayed. The calculation of the geometrical optimization, DOA, Nucleus Independent Chemical Shifts (NICS) and Ring Stretching Vibration Raman Spectroscopy Frequency (RSVRSF) for the aromatic ring molecules - Gn Hn m (G = C, Si, Ge, n = 3, 5-8, m = +1, -1, 0, +1, +2) were calculated using the method of Density Functional Theory (DFT)...
May 8, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Seon Young Kim, Yumi Park, Hyunjin Kim, Jimyung Kim, Sun Hoe Koo, Gye Cheol Kwon
Rapid screening of urinary tract infection is important to determine antibiotic treatment and reduce unnecessary urine culture. We evaluated the performance of the new flow cytometry-based UF-5000 automated urine analyzer (Sysmex, Kobe, Japan). A total of 1,430 urine samples from 1,226 patients were analyzed and compared with urine cultures to which a Previ Isola (bioMérieux, Marcy l'Etoile, France) system was applied. In total, 878 of 1,430 urine cultures (61.4%) produced ≥ 103 CFU/mL bacterial growth [lsqb]309 with Gram-negative (GN) bacteria, 517 with Gram-positive (GP) bacteria, and 52 mixed cultures[rsqb], with 336 samples (23...
May 16, 2018: Journal of Clinical Microbiology
A K M Mahmudul Haque, Sedong Kim, Junhyo Kim, Jungpil Noh, Sunchul Huh, Byeongkeun Choi, Hanshik Chung, Hyomin Jeong
Surface modification is necessary to decrease graphene's (GN) stacking process and increase its advantageous properties. In this study, the effects of acid treatment and grinding processes on the structural integrity of GN have been studied. Morphological and structural characteristics of modified GN were investigated by field emission scanning electron microscopy, transmission electron microscopy, gas Pycnometer, particle size analyzer, X-ray diffractometer, UV-Vis spectroscopy and thermal conductivity measurement system which expose some strong evidences of the effects of purification and grinding process on GN nanoparticles in order to get GN based better nanofluid dispersed in water which gives 1...
January 1, 2018: Journal of Nanoscience and Nanotechnology
Nhat-Thien Nguyen, Dan-Dan Zheng, Shiao-Shing Chen, Chang-Tang Chang
Hydrogen is considered as a promising energy source with its high energy yield, renewable, environment friendly properties. TiO2 modified with noble metal and nonmetal is widely used. In this study, Pt and graphene (GN) were used to modify TiO2 nanoparticles. GN/TiO2 (TG), Pt-TiO2 (PT), Pt-GN/TiO2 (PTG) was successfully synthesized by modified Hummers' method, alcohol thermal and photodeposition method, respectively. The characterizations of the synthesized catalysts by UV-vis/DRS, components analysis, XRD and TEM analysis were conducted...
January 1, 2018: Journal of Nanoscience and Nanotechnology
José Vidal-Gancedo, Vega Lloveras, Flonja Liko, Luiz F Pinto, Jose L Muñoz-Gómez
Two generations of phosphorous dendrimers were synthesized and fully functionalized with TEMPO radicals via acrylamido or imino group linkers to evaluate the impact of the linker substitution on the radical-radical interactions. A drastic change in the way that the radicals interacted among them was observed by EPR and CV studies: while radicals in Gn-imino-TEMPO dendrimers presented a strong spin-spin interaction, in the Gn-acrylamido-TEMPO ones they acted mainly as independent radicals. This shows that these interactions could be tuned by the solely substitution of the radical linker, opening the perspective of controlling and modulating the extension of these interactions depending on each application...
May 10, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Kleopatra Georgantzi, Erik G Sköldenberg, Mats Stridsberg, Per Kogner, Åke Jakobson, Eva Tiensuu Janson, Rolf H B Christofferson
Chromogranin A (CgA) and neuron specific enolase (NSE) are important markers in adult neuroendocrine tumors (NET). Neuroblastoma (NB) has certain neuroendocrine properties. The aim of this study was to correlate blood concentrations of CgA, chromogranin B (CgB), and NSE to prognostic factors and outcome in children with NB. Blood samples from 92 patients with NB, 12 patients with benign ganglioneuroma (GN), 21 patients with non-NB solid tumors, 10 patients with acute leukemias, and 69 healthy children, were analyzed...
May 8, 2018: Pediatric Hematology and Oncology
Liling Wu, Manqiu Yang, Xiaogang Feng, Lingwei Jin, Chunyi Wu, Shuang Cui, Zhanmei Zhou, Xiaohong Zhong, Meng Shi, Zhichen Yang, Wei Cao
Background: One of the major challenges in improving the management of antineutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN) is the lack of a disease-specific indicator for histological lesions and disease activity. Here we tested the utility of urinary angiotensinogen (UAGT) as a biomarker of renal disease activity in ANCA-GN. Methods: A prospective, two-stage cohort study was performed in ANCA-GN patients. In Stage I, UAGT was measured at the time of renal biopsy in 69 patients from two centers (test set) and 25 patients from two other centers (validation set)...
May 4, 2018: Nephrology, Dialysis, Transplantation
Noemí Antón-Millán, Javier Garcia-Tojal, Marta Marty-Roda, Sebastiano Garroni, Santiago Cuesta-López, Juan Antonio Tamayo-Ramos
The modification of carbon nanomaterials with biological molecules paves the way towards their use in biomedical and biotechnological applications, such as next generation biocatalytic processes, development of biosensors, implantable electronic devices, or drug delivery. In this study, different commercial graphene derivatives, namely, monolayer graphene oxide (GO), graphene oxide nanocolloids (GOC), and polycarboxylate functionalized graphene nanoplatelets (GN), were compared as biomolecule carrier matrices...
May 7, 2018: ACS Applied Materials & Interfaces
H Park, W Y Park, S S Kang, S M Yeo, S Han, S B Park, K Jin
BACKGROUND: The clinical outcomes after kidney transplantation (KT) according to the types of glomerulonephritis (GN) as the cause of end-stage renal disease (ESRD) are various, but there are not many studies on this. METHODS: Among 1,253 patients who had KT between November 1982 and January 2017, 183 recipients with biopsy-proven GN as the primary cause of ESRD were enrolled. We analyzed the incidence of recurrent GN and the factors associated with recurrence and graft and patient survivals...
May 2018: Transplantation Proceedings
Yan-Rong Kuai, Zhan-Ju He, Sheng Wang, Kai Zhang, Cheng Zeng, Liang Chen, Qing Xue, Jing Shang, Hui-Xia Yang, Yang Xu
Objective: To investigate whether testicular histology influences the clinical outcomes of intracytoplasmic sperm injection (ICSI) in men with non-obstructive azoospermia (NOA). METHODS: We retrospectively analyzed the clinical data about 73 cases of NOA undergoing ICSI, including 105 ICSI cycles and 79 embryo transfer cycles. The infertility of the patients was attributed to male factors only or both male and female tube factors and the females' age was ≤38 years...
October 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
Fang Xu, Chong Wang, Xiaoju Shi, Jie Hou, Xiaolin Guo, Pujun Gao
BACKGROUND: Most cases of hepatitis B virus-associated glomerulonephritis (HBV-GN) occur in children and present with serum HBsAg positivity. Few studies have investigated adult HBV-GN patients who are serum HBsAg-negative. This study aimed to determine the clinical and pathological features of serum HBsAg-negative adult HBV-GN patients. METHODS: Clinical, pathologic and laboratory findings were collected and analyzed in a cohort of 27 adult HBV-GN patients who were serum HBsAg negative upon diagnosis...
May 2, 2018: Journal of Medical Virology
Jong Man Park, Harin Lee, Sangheon Song, Eun Young Seong, Ihm Soo Kwak, Sung Who Park, Young-Keum Kim, Nari Shin, Mee Young Sol
C4 glomerulopathy is a recently introduced entity that presents with bright C4d staining and minimal or absent immunoglobulin and C3 staining. We report a case of a 62-year-old man with C4 glomerulonephritis (GN) and uveitis. He presented to the nephrology department with proteinuria and hematuria. The patient also had intermediate uveitis along with proteinuria and hematuria. A kidney biopsy that was performed in light of continuing proteinuria and hematuria showed a focal proliferative, focal sclerotic glomerulopathy pattern on light microscopy, absent staining for immunoglobulin or C3 by immunofluorescence microscopy, with bright staining for C4d on immunohistochemistry, and electron-dense deposits on electron microscopy...
April 30, 2018: Journal of Korean Medical Science
Alyssa N King, Samiksha Borkar, David J Samuels, Zachary Batz, Logan Bulock, Marat R Sadykov, Kenneth W Bayles, Shaun R Brinsmade
In Staphylococcus aureus , the global transcriptional regulator CodY modulates the expression of hundreds of genes in response to the availability of GTP and the branched-chain amino acids isoleucine, leucine, and valine (ILV). CodY DNA-binding activity is high when GTP and ILV are abundant. When GTP and ILV are limited, CodY's affinity for DNA drops, altering expression of CodY regulated targets. In this work, we investigated the impact of guanine nucleotides on S. aureus physiology and CodY activity by constructing a guaA null mutant (Δ guaA )...
April 30, 2018: Journal of Bacteriology
Narayan Kumar Shrestha, Junye Wang
An ecosystem in a cold climate river basin is vulnerable to the effects of climate change affecting permafrost thaw and glacier retreat. We currently lack sufficient data and information if and how hydrological processes such as glacier retreat, snowmelt and freezing-thawing affect sediment and nutrient runoff and transport, as well as N2 O emissions in cold climate river basins. As such, we have implemented well-established, semi-empirical equations of nitrification and denitrification within the Soil and Water Assessment Tool (SWAT), which correlate the emissions with water, sediment and nutrients...
April 27, 2018: Environmental Pollution
Katheryn Bachmann, Kaitlin Sipos, Violette Lavender, Lisa L Hunter
BACKGROUND: The video head impulse test (vHIT) is a new tool being used in vestibular clinics to assess the function of all six semicircular canals (SCCs) by measuring the gain of the vestibulo-ocular reflex (VOR) in response to rapid head turns. Whereas vHIT has been validated in adults for all SCCs, there are few studies describing the normal response in children, particularly for stimulation of the vertical canals. PURPOSE: The purpose of this study was to characterize the normal vHIT response for all six SCCs in children aged 4-12 years...
May 2018: Journal of the American Academy of Audiology
Tiphany Chrun, Sandra Lacôte, Céline Urien, Luc Jouneau, Céline Barc, Edwige Bouguyon, Vanessa Contreras, Audrey Ferrier-Rembert, Christophe N Peyrefitte, Nuria Busquets, Enric Vidal, Joan Pujols, Philippe Marianneau, Isabelle Schwartz-Cornil
Rift Valley fever virus, a phlebovirus endemic in Africa, causes serious diseases in ruminants and humans. Due to the high probability of new outbreaks and spread to other continents where competent vectors are present, vaccine development is an urgent priority as no licensed vaccines are available outside areas of endemicity. In this study, we evaluated in sheep the protective immunity induced by DNA vaccines encoding the extracellular portion of the Gn antigen which was either or not targeted to antigen-presenting cells...
2018: NPJ Vaccines
Yuanyuan Zhu, Yan Yue, Sidong Xiong
B6/lpr mouse strain is a well-known systemic lupus erythematosus murine model characterized by uncontrolled lymphoproliferation and autoantibody production. However, it displays a delayed and mild development of lupus nephritis (LN), which is not conducive to the research of the pathogenesis and therapeutic strategies of this condition. Our previous study demonstrated that activated lymphocyte-derived DNA (ALD-DNA) could induce high urine protein levels and severe glomerulonephritis (GN) in BALB/c mice. In the present study, we tried to remedy delayed urine protein production and mild GN in B6/lpr mice via ALD-DNA immunization...
April 28, 2018: Clinical and Experimental Immunology
Glauciane Garcia de Figueiredo, Adriana Aparecida Marques, Marisa Márcia Mussi-Pinhata, Wilson Araújo Silva, Aparecida Yulie Yamamoto
It is still not well known, in a population with high HCMV seroprevalence, if a child with congenital infection harbors multiple viral strains at birth, and if the prolonged viral excretion in these children is secondary to the persistence of the same viral strain. To verify the genomic diversity of HCMV detected in congenitally infected children, the nucleotide viral sequences from urine and/or saliva obtained at birth from 14 newborns with congenital infection and breast milk obtained from mothers of 5 of these children were analyzed...
April 28, 2018: Journal of Medical Virology
Sanjeev Sethi, S Vincent Rajkumar, Vivette D D'Agati
Monoclonal gammopathies are characterized by the overproduction of monoclonal Ig (MIg) detectable in the serum or urine resulting from a clonal proliferation of plasma cells or B lymphocytes. The underlying hematologic conditions range from malignant neoplasms of plasma cells or B lymphocytes, including multiple myeloma and B-cell lymphoproliferative disorders, to nonmalignant small clonal proliferations. The term MGUS implies presence of an MIg in the setting of a "benign" hematologic condition without renal or other end organ damage...
April 27, 2018: Journal of the American Society of Nephrology: JASN
Manuela Nestola, Nicoletta De Matthaeis, Pietro Manuel Ferraro, Paola Fuso, Stefano Costanzi, Gian Franco Zannoni, Fabrizio Pizzolante, Sabina Vasquez Quadra, Giovanni Gambaro, Gian Ludovico Rapaccini
PURPOSE: To compare contrast-enhanced ultrasonography (CEUS)-derived time-intensity (TI) curves with histological findings in kidneys of patients affected by chronic glomerulonephritides (GN) in the early stage of disease. METHODS: Research ethics committee approval and patient written informed consent were obtained. Thirty-one patients who showed clinical and laboratory signs of GN, with preserved renal function, were consecutively enrolled. They underwent kidney CEUS, from which TI curves were obtained, and kidney biopsy...
April 24, 2018: Journal of Ultrasound
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