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https://www.readbyqxmd.com/read/28937979/molecular-genomic-characterization-of-tick-and-human-derived-severe-fever-with-thrombocytopenia-syndrome-virus-isolates-from-south-korea
#1
Seok-Min Yun, Su-Jin Park, Sun-Whan Park, WooYoung Choi, Hye Won Jeong, Young-Ki Choi, Won-Ja Lee
BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne viral disease caused by the SFTS virus (SFTSV) from Bunyaviridae that is endemic in East Asia. However, the genetic and evolutionary characteristics shared between tick- and human-derived Korean SFTSV strains are still limited. METHODOLOGY/PRINCIPAL FINDINGS: In this study we identify, for the first time, the genome sequence of a tick (Haemaphysalis longicornis)-derived Korean SFTSV strain (designated as KAGWT) and compare this virus with recent human SFTSV isolates to identify the genetic variations and relationships among SFTSV strains...
September 22, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28935578/abin1-determines-severity-of-glomerulonephritis-via-activation-of-intrinsic-glomerular-inflammation
#2
Erik A Korte, Dawn J Caster, Michelle T Barati, Min Tan, Shirong Zheng, Celine C Berthier, Frank C Brosius, Mark B Vieyra, Ryan M Sheehan, Michele Kosiewicz, Marcin Wysoczynski, Patrick M Gaffney, David J Salant, Kenneth R McLeish, David W Powell
Transcription factor NF-κB regulates expression of numerous genes that control inflammation and is activated in glomerular cells in glomerulonephritis (GN). We previously identified genetic variants for a NF-κB regulatory, ubiquitin binding protein ABIN1 as risk factors for GN in systemic autoimmunity. The goal here was to define glomerular inflammatory events controlled by ABIN1 function in GN. Nephrotoxic serum nephritis was induced in wild-type (WT) and ubiquitin binding deficient ABIN1[D485N] mice; and renal pathophysiology and glomerular inflammatory phenotypes were assessed...
September 18, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28933339/incidence-and-outcome-of-lupus-nephritis-in-french-polynesia%C3%A2
#3
Antoine Delarche, Catherine Lumbroso, Alain Fournier, Ronan Delaval, Jacques Pourrat, Pascale Testevuide, Sylvie Leou, Christophe Cordonnier, Dominique Chauveau, Stanislas Faguer
OBJECTIVE: Outcomes of systemic lupus erythematosus (SLE) and lupus nephritis (LN) are highly heterogeneous among some populations because of interactions between genetic, epigenetic, environmental, and socioeconomic factors. A better characterization of social and ethnic disparities in mixed populations may thus help to develop individualized treatment regimens. MATERIALS AND METHODS: Retrospective observational study including all patients with LN diagnosed between January 1993 and January 2014 in the only Nephrology Department of French Polynesia...
September 21, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28926632/risk-analysis-of-inter-species-reassortment-through-a-rift-valley-fever-phlebovirus-mp-12-vaccine-strain
#4
Hoai J Ly, Nandadeva Lokugamage, Shoko Nishiyama, Tetsuro Ikegami
Rift Valley fever (RVF) is a mosquito-borne zoonotic disease endemic to Africa and the Arabian Peninsula. The causative agent, Rift Valley fever phlebovirus (RVFV), belongs to the genus Phlebovirus in the family Phenuiviridae and causes high rates of abortions in ruminants, and hemorrhagic fever, encephalitis, or blindness in humans. Viral maintenance by mosquito vectors has led to sporadic RVF outbreaks in ruminants and humans in endemic countries, and effective vaccination of animals and humans may minimize the impact of this disease...
2017: PloS One
https://www.readbyqxmd.com/read/28926305/structural-relationships-among-the-revised-reinforcement-sensitivity-theory-and-grandiose-and-vulnerable-narcissism
#5
Christopher C Spencer, Joshua D Foster, Jeffrey S Bedwell
Research shows that grandiosity and vulnerability are distinct aspects of narcissism. The Contemporary Clinical Model (CCM) of narcissism suggests that individuals fluctuate between grandiose narcissism (GN) and vulnerable narcissism (VN). The authors examine the relative contributions of the Behavioral Approach System (BAS), the Behavioral Inhibition System (BIS), and the Fight-Flight-Freeze System (FFFS) in the Revised Reinforcement Sensitivity Theory of Personality (r-RST) to GN and VN. Few studies examine the r-RST, and even fewer examine the VN and GN distinction...
September 19, 2017: Journal of Personality Disorders
https://www.readbyqxmd.com/read/28911262/alleviation-by-gamma-amino-butyric-acid-supplementation-of-chronic-heat-stress-induced-degenerative-changes-in-jejunum-in-commercial-broiler-chickens
#6
Rasha A Al Wakeel, Mustafa Shukry, Ahmed Abdel Azeez, Shawky Mahmoud, Michel Fahmy Saad
High ambient temperature adversely influences poultry production. In the present study, gamma amino butyric acid (GABA) supplementation was used to alleviate the adverse changes due to heat stress (HS) in a broiler chicken strain (Ross 308). At 21 days of age, the birds were divided into four groups of 13. Two groups were housed under normal room temperature, one group was given orally 0.2 ml 0.9% physiological saline (CN) daily, the other group received 0.2 ml of 0.5% GABA solution orally (GN). A third group was exposed to environmental HS (33 ± 1 °C lasting for 2 weeks) + physiological saline (CH) and a fourth group was exposed to HS + GABA supplementation (GH)...
September 15, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28901616/regularization-of-nonlinear-decomposition-of-spectral-x-ray-projection-images
#7
Nicolas Ducros, Juan Felipe Perez-Juste Abascal, Bruno Sixou, Simon Rit, Françoise Peyrin
PURPOSE: Exploiting the x-ray measurements obtained in different energy bins, spectral computed tomography (CT) has the ability to recover the 3-D description of a patient in a material basis. This may be achieved solving two subproblems, namely the material decomposition and the tomographic reconstruction problems. In this work, we address the material decomposition of spectral x-ray projection images, which is a nonlinear ill-posed problem. METHODS: Our main contribution is to introduce a material-dependent spatial regularization in the projection domain...
September 2017: Medical Physics
https://www.readbyqxmd.com/read/28900615/exploring-genetic-numeracy-skills-in-a-sample-of-u-s-university-students
#8
Margo W Bergman, Patricia Goodson, Heather Honoré Goltz
Misconceptions concerning numerical genetic risk exist even within educated populations. To more fully characterize and understand the extent of these risk misunderstandings, which have large potential impact on clinical care, we analyzed the responses from 2,576 students enrolled at 2 Southwestern universities using the PGRID tool, a 138-item web-based survey comprising measures of understanding of genetics, genetic disease, and genetic risk. The primary purpose of this study was to characterize the intersection of risk perception and knowledge, termed genetic numeracy (GN)...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28899644/transcriptomics-reveals-tissue-organ-specific-differences-in-gene-expression-in-the-starfish-patiria-pectinifera
#9
Chan-Hee Kim, Hye-Jin Go, Hye Young Oh, Yong Hun Jo, Maurice R Elphick, Nam Gyu Park
Starfish (Phylum Echinodermata) are of interest from an evolutionary perspective because as deuterostomian invertebrates they occupy an "intermediate" phylogenetic position with respect to chordates (e.g. vertebrates) and protostomian invertebrates (e.g. Drosophila). Furthermore, starfish are model organisms for research on fertilization, embryonic development, innate immunity and tissue regeneration. However, large-scale molecular data for starfish tissues/organs are limited. To provide a comprehensive genetic resource for the starfish Patiria pectinifera, we report de novo transcriptome assemblies and global gene expression analysis for six P...
September 9, 2017: Marine Genomics
https://www.readbyqxmd.com/read/28895232/anion-directed-metallocages-a-study-on-the-tendency-of-anion-templation
#10
Jing-Yun Wu, Ming-Shiou Zhong, Ming-Hsi Chiang
Self-assembly of Cu(NO3)2∙3H2O and a di(3-pyridylmethyl)amine (dpma) ligand with addition of different acids (HNO3, HOAc, HCl, HClO4, HOTf, HPF6, HBF4, and H2SO4) afforded a family of anion-templated tetragonal metallocages having a cationic prismatic structure of [(Gn-){Cu2(Hdpma)4}](8-n)+ (Gn- = NO3-, PF6-, SiF62-) with different ligating anions/solvents (NO3-, Cl-, ClO4-, OTf-, H2O) outside the cage. The systematic competitive experiments have significantly rationalized a tendency of anion templation towards the formation of metallocages [(Gn-){Cu2(Hdpma)4}](8-n)+ as SiF62- ~ PF6- > NO3- > SO42- ~ ClO4- ~ BF4-...
September 12, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28893375/a-genomic-lifespan-program-that-reorganises-the-young-adult-brain-is-targeted-in-schizophrenia
#11
Nathan G Skene, Marcia Roy, Seth Gn Grant
The genetic mechanisms regulating the brain and behaviour across the lifespan are poorly understood. We found that lifespan transcriptome trajectories describe a calendar of gene regulatory events in the brain of humans and mice. Transcriptome trajectories defined a sequence of gene expression changes in neuronal, glial and endothelial cell-types, which enabled prediction of age from tissue samples. A major lifespan landmark was the peak change in trajectories occurring in humans at 26 years and in mice at 5 months of age...
September 12, 2017: ELife
https://www.readbyqxmd.com/read/28886934/transglutaminase-6-antibodies-in-gluten-neuropathy
#12
Panagiotis Zis, Dasappaiah Ganesh Rao, Ptolemaios Georgios Sarrigiannis, Pascale Aeschlimann, Daniel P Aeschlimann, David Sanders, Richard A Grünewald, Marios Hadjivassiliou
BACKGROUND: TG6 antibodies have been shown to be a marker of gluten ataxia but their presence in the context of other neurological manifestations of gluten sensitivity has not been explored. We investigated the presence of TG6 antibodies in gluten neuropathy (GN), defined as as an otherwise idiopathic peripheral neuropathy associated with serological markers of gluten sensitivity (one or more of antigliadin IgG and/or IgA, endomysial and transglutaminase-2 antibodies). METHODS: This was a cross-sectional study conducted at the Sheffield Institute of Gluten Related Diseases, Royal Hallamshire Hospital, Sheffield, UK...
August 10, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28884034/snakebite-induced-thrombotic-microangiopathy-leading-to-renal-cortical-necrosis
#13
Ying Mao Gn, Arvind Ponnusamy, Vikram Thimma
Renal complications from snakebite result in high mortality and morbidity. Acute kidney injury (AKI) occurs in 5-30% of cases. Renal manifestation could include acute tubular necrosis, cortical necrosis, interstitial nephritis, glomerulonephritis, and vasculitis. We present a case of thrombotic microangiopathy (TMA) resulting in renal cortical necrosis. Renal biopsy showed fibrin thrombi in glomeruli and arterioles with cortical necrosis. Our patient progressed to end-stage renal disease.
2017: Case Reports in Nephrology
https://www.readbyqxmd.com/read/28881339/interstitial-immunostaining-and-renal-outcomes-in-antineutrophil-cytoplasmic-antibody-associated-glomerulonephritis
#14
Duvuru Geetha, Sanjeev Sethi, An S De Vriese, Ulrich Specks, Cees G M Kallenberg, Noha Lim, Robert Spiera, E William St Clair, Peter A Merkel, Philip Seo, Paul A Monach, Nicola Lepori, Barri J Fessler, Carol A Langford, Gary S Hoffman, Rishi Sharma, John H Stone, Fernando C Fervenza
BACKGROUND: Immunopathologic features predict renal function at baseline and follow-up in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (GN). The interstitial infiltrate consists predominantly of T lymphocytes, but their pathophysiologic significance is unclear, especially in light of the success of B-cell-directed therapy. METHODS: Renal biopsies from 33 patients treated with cyclophosphamide (CYC; n = 17) or rituximab (RTX; n = 16) in the RTX in ANCA-associated vasculitis (RAVE) trial were classified according to the new ANCA GN classification...
September 8, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28881045/diagnostic-accuracy-of-immunofluorescence-versus-immunoperoxidase-staining-to-distinguish-immune-complex-mediated-glomerulonephritis-and-c3-dominant-glomerulopathy
#15
Yassine Bouatou, Jesper Kers, Marie S N Chevalier-Florquin, Nike Claessen, Tri Q Nguyen, Jeffrey Damman, Henrique Proença, Joris J T H Roelofs, Sandrine Florquin
AIMS: Membranoproliferative glomerulonephritis (MPGN) has been reclassified from an electron microscopy to an immunofluorescence (IF) based semi quantitative classification with immunoperoxidase (IP) technique as a backup option when IF is not possible. However, no data are available on the interobserver variability, the correlation and the reclassification of MPGN based on these two techniques. METHODS & RESULTS: We retrospectively analyzed cases of type 1 MPGN...
September 7, 2017: Histopathology
https://www.readbyqxmd.com/read/28879770/in-situ-synthesis-of-monomer-casting-nylon-6-graphene-polysiloxane-nano-composites-intercalation-structure%C3%AF-synergistic-reinforcing-and-friction-reducing-effect
#16
Chengjie Li, Meng Xiang, Xiaowen Zhao, Lin Ye
Based on the industrialized graphene nanosheets (GN) product, MC PA6/GN-3-aminopropyl-terminated poly(dimethylsiloxan) (APDMS) nano-composite was in situ synthesized through anchoring effect of APDMS onto GN surface. APDMS/PA6 molecules were confirmed to intercalate into GN layers by formation of strong interfacial interactions. The intercalation ratio and the average layer thickness of the grafted GN sample decreased in presence of APDMS. Moreover, for MC PA6/GN-APDMS nano-composite, GN-APDMS was uniformly distributed in the matrix and no phase separation was observed...
September 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28879481/association-between-the-number-of-oocytes-retrieved-and-cumulative-live-birth-rate-in-women-aged-35-40%C3%A2-years-undergoing-long-gnrh-agonist-ivf-icsi-cycles
#17
Jianjun Zhou, Bin Wang, Yali Hu, Haixiang Sun
PURPOSE: To study the association between the numbers of oocytes retrieved and the cumulative live birth rates (LBR) in women aged 35-40 years undergoing long GnRH agonist IVF/ICSI cycles. METHODS: A total of 931 women aged 35-40 years who underwent their first cycle of IVF/ICSI treatment between January 2010 and December 2013 at Nanjing Drum Tower Hospital were identified and reviewed. The main endpoint of this study was the cumulative LBR after one complete oocyte retrieval, which included fresh and all subsequent frozen-thaw embryo transfer cycles...
September 6, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28874227/the-impact-of-virus-population-diversity-on-the-dynamics-of-cytomegalovirus-dnaemia-in-allogeneic-stem-cell-transplant-recipients
#18
Víctor Vinuesa, María Alma Bracho, Eliseo Albert, Carlos Solano, Manuela Torres-Puente, Estela Giménez, Fernando González-Candelas, David Navarro
Mixed cytomegalovirus (CMV) infections are associated with delayed viral clearance in solid organ transplant recipients. We investigated whether this could be extrapolated to allogeneic stem cell transplant (allo-SCT) recipients. A total of 48 plasma specimens, obtained during 29 episodes of active CMV infection in 25 non-consecutive allo-SCT patients, were analysed. Baseline blood specimens, drawn shortly prior to the inception of pre-emptive antiviral therapy (pre-treatment specimen; n=29), as well as follow-up samples obtained either after the initiation of antiviral therapy (post-treatment specimen; n=15) or during recurrent episodes (n=4) were analysed...
September 6, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28851633/acute-postinfectious-glomerulonephritis-associated-with-scabies-in-the-elderly-a-case-report
#19
Di Wang, Li Li, Lei Wei, Yingying Liu, Shiren Sun
Acute postinfectious glomerulonephritis (GN) secondary to scabies were mainly documented as early as in 1980s, and in all these published cases no histopathological evidence of renal biopsy were reported regarding scabies and renal damage. The delay in scabies treatment can result in a greater risk of secondary bacterial infections that can become invasive and/or lead to severe post-infective complications such as post-streptococcal glomerulonephritis. In diagnostic procedures, the clinical presentation of scabies is often atypical especially in elderly people patients...
August 26, 2017: Parasitology International
https://www.readbyqxmd.com/read/28845474/the-susceptibility-of-bacterial-endophthalmitis-isolates-to-vancomycin-ceftazidime-and-amikacin-a-23-year-review
#20
Shilpa Kodati, Andrew W Eller, Regis P Kowalski
PURPOSE: To investigate the in vitro susceptibility of Gram-positive and Gram-negative endophthalmitis bacterial isolates to vancomycin, amikacin, and ceftazidime over a 23-year period. DESIGN: Retrospective non-comparative laboratory case series. SUBJECTS: Endophthalmitis patients that were culture positive for bacteria. METHODS: Laboratory records of bacteria isolated from endophthalmitis specimens collected from January 1(st) 1993 to December 31(st) 2015 were reviewed for incidence and standard susceptibility testing...
May 2017: Ophthalmology retina
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