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https://www.readbyqxmd.com/read/28731405/pro-death-nmda-receptor-signaling-is-promoted-by-the-glun2b-c-terminus-independently-of-dapk1
#1
Jamie McQueen, Tomas J Ryan, Sean McKay, Katie Fm Marwick, Paul E Baxter, Sarah M Carpanini, Thomas M Wishart, Thomas H Gillingwater, Jean C Manson, David Ja Wyllie, Seth Gn Grant, Barry McColl, Noboru Komiyama, Giles E Hardingham
Aberrant NMDA receptor (NMDAR) activity contributes to several neurological disorders, but direct antagonism is poorly tolerated therapeutically. The GluN2B cytoplasmic C-terminal domain (CTD) represents an alternative therapeutic target since it potentiates excitotoxic signaling. The key GluN2B CTD-centred event in excitotoxicity is proposed to involve its phosphorylation at Ser-1303 by DAPK1, that is blocked by a neuroprotective cell-permeable peptide mimetic of the region. Contrary to this model, we find that excitotoxicity can proceed without increased Ser-1303 phosphorylation, and is unaffected by DAPK1 deficiency in vitro or following ischemia in vivo...
July 21, 2017: ELife
https://www.readbyqxmd.com/read/28726875/time-resolved-spectroscopic-analysis-of-the-light-energy-harvesting-mechanism-in-carbazole-dendrimers-with-a-blue-phosphorescent-ir-complex-core
#2
Yang-Jin Cho, So-Yoen Kim, Mi Rang Son, Ho-Jin Son, Dae Won Cho, Sang Ook Kang
In order to investigate the light-energy harvesting mechanism, a series of dendrimers with a heteroleptic iridium(iii) complex core, [Ir(dmb)2(pic-Czn)] (Gn: n = 1, 2, and 3), with 2,6-difluoro-3-(4-methylpyridin-2-yl)benzonitrile (dmb) as the cyclometallating ligand and 3-hydroxypicolinate (pic) as the ancillary ligand, connected to carbazole-based dendrons (Czn: n = 2, 4, and 8) was synthesized. The Ir centred complex [Ir(dmb)2(pic-OCH3), G0] shows a blue emission at <500 nm, which is assigned to metal-to-ligand charge-transfer ((3)MLCT) phosphorescence...
July 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28722531/patterns-of-renal-disease-in-south-korea-a-20-year-review-of-a-single-center-renal-biopsy-database
#3
Ho Sik Shin, Dae Hyeon Cho, Soo Kyoung Kang, Hyun Jeong Kim, Soo Young Kim, Joung Wook Yang, Gyong Hoon Kang, Ye Na Kim, Yeonsoon Jung, Bong-Kwon Cheon, Hark Rim
BACKGROUND: Several registries and centers have reported the results of renal biopsies from different parts of the world. As there are few data regarding the epidemiology of glomerulonephritis (GN) in South Korea, we conducted this study on renal biopsy findings during the last 20 years from a single center. METHODS: Data for 818 patients who underwent renal biopsy at our center between 1992 and 2011 were collected retrospectively. All kidney specimens were examined with light microscopy (LM) and immunofluorescent microscopy (IF)...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/28722133/rheological-characterization-of-gluten-from-triticale-x-triticosecale-wittmack
#4
Anna Pruska-Kędzior, Agnieszka Makowska, Zenon Kędzior, Bolesław P Salmanowicz
BACKGROUND: Triticale gluten still remains very poorly characterized rheologically. In this study the mechanical spectra of gluten isolated from four triticale cultivars were registered and fitted with Cole-Cole functions yielding the viscoelastic plateau parameters. Master spectra were calculated. Retardation test was performed and used to calculate the composite mechanical spectra and the width of viscoelastic plateau l. Protein fractional composition of triticale flour and gluten was studied using capillary zone electrophoresis...
July 19, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28719961/artyfechinostomum-malayanum-metacercariae-encysted-in-pila-sp-snails-purchased-from-phnom-penh-cambodia
#5
Woon-Mok Sohn, Tai-Soon Yong, Keeseon S Eom, Muth Sinuon, Hoo-Gn Jeoung, Jong-Yil Chai
The metacercariae of Artyfechinostomum malayanum (Leiper, 1911) Mendheim, 1943 were discovered in Pila sp. snails purchased from a market in Phnom Penh, Cambodia. They were isolated from the snails using the artificial digestion technique and were orally fed to 2 hamsters, 1 rat, and 2 mice to obtain the adult flukes. The metacercariae were round, 145-165 μm in diameter, having a cyst wall of 6-10 μm in thickness, a head collar and collar spines, and characteristic features of excretory granules. Adult flukes were recovered in the small intestines of the animals at days 14 and 32 post infection and were morphologically observed using a light microscope and a scanning electron microscope...
June 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28717059/pharmacological-effects-of-a-vitamin-k1-2-3-epoxide-reductase-vkor-inhibitor-3-acetyl-5-methyltetronic-acid-on-cisplatin-induced-fibrosis-in-rats
#6
Masashi Uchida, Tomoya Miyoshi, Yohei Miyamoto
Cisplatin (CDDP) is a chemotherapeutic agent that is widely used in the treatment of lymphomas and solid malignancies. However, its clinical usage is limited by its severe side effects in the kidneys. Glomerular and tubular injuries in the kidneys commonly progress to interstitial fibrosis and, ultimately, the end stage of renal failure. We previously reported that 3-acetyl-5-methyltetronic acid (AMT) had inhibitory effects on rat renal vitamin K1 2,3-epoxide reductase (VKOR) in vitro and also suppressed mesangial cell proliferation and, consequently, the formation of fibrosis via the vitamin K-dependent activation of the growth arrest-specific 6 (Gas6)/Axl pathway in anti-Thy-1 glomerulonephritis (Thy-1 GN) in rats...
July 16, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28715198/structural-variations-in-hybrid-all-nanoparticle-gibbsite-nanoplatelet-cellulose-nanocrystal-multilayered-films
#7
Clélia Martin, Robert David Barker, Erik B Watkins, Frederic Dubreuil, Emily D Cranston, Laurent Heux, Bruno Jean
Cellulose nanocrystals (CNCs) are promising bio-sourced building blocks for the production of high performance materials. In the last ten years, CNCs have been used in conjunction with polymers for the design of multilayered thin films via the layer-by-layer assembly technique. Herein, polymer chains have been replaced with positively charged inorganic gibbsite nanoplatelets (GN) to form hybrid "nanoparticle-only" composite films. A combination of atomic force microscopy and neutron reflectivity experiments was exploited to investigate the growth and structure of the films...
July 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28714123/defect-engineering-of-chalcogen-tailored-oxygen-electrocatalysts-for-rechargeable-quasi-solid-state-zinc-air-batteries
#8
Jing Fu, Fathy M Hassan, Cheng Zhong, Jun Lu, Han Liu, Aiping Yu, Zhongwei Chen
A critical bottleneck limiting the performance of rechargeable zinc-air batteries lies in the inefficient bifunctional electrocatalysts for the oxygen reduction and evolution reactions at the air electrodes. Hybridizing transition-metal oxides with functional graphene materials has shown great advantages due to their catalytic synergism. However, both the mediocre catalytic activity of metal oxides and the restricted 2D mass/charge transfer of graphene render these hybrid catalysts inefficient. Here, an effective strategy combining anion substitution, defect engineering, and the dopant effect to address the above two critical issues is shown...
July 17, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28713213/secondary-motion-in-three-dimensional-branching-networks
#9
Abhijit Guha, Kaustav Pradhan
A major aim of the present work is to understand and thoroughly document the generation, the three-dimensional distribution, and the evolution of the secondary motion as the fluid progresses downstream through a branched network. Six generations (G0-G5) of branches (involving 63 straight portions and 31 bifurcation modules) are computed in one go; such computational challenges are rarely taken in the literature. More than 30 × 10(6) computational elements are employed for high precision of computed results and fine quality of the flow visualization diagrams...
June 2017: Physics of Fluids
https://www.readbyqxmd.com/read/28713167/cell-biology-connexin-connections-in-gn
#10
Grant Otto
No abstract text is available yet for this article.
July 17, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28706744/management-of-oromandibular-dystonia-a-case-report-and-literature-update
#11
Suma Gn, Adrita Nag
Oromandibular dystonia (OMD) is a movement disorder characterized by involuntary, paroxysmal, and patterned muscle contractions of varying severity resulting in sustained spasms of masticatory muscles, affecting the jaws, tongue, face, and pharynx. It is most commonly idiopathic or medication-induced, but peripheral trauma sometimes precedes the condition. We present a case report of a 26-year-old female patient who suffered repetitive bouts of hemifacial muscle contractions for 2 years on closing the mouth which interfered in patient's well-being and quality of life by hampering her ability to eat and talk and to the extent of inability to breath due to contractions of her neck muscles...
2017: Case Reports in Dentistry
https://www.readbyqxmd.com/read/28700222/bioavailability-of-carbon-nanomaterial-adsorbed-polycyclic-aromatic-hydrocarbons-to-p-promelas-influence-of-adsorbate-molecular-size-and-configuration
#12
Erica N Linard, Onur G Apul, Tanju Karanfil, Peter van den Hurk, Stephen J Klaine
Despite carbon nanomaterials' (CNMs) potential to alter the bioavailability of adsorbed contaminants, information characterizing the relationship between adsorption behavior and bioavailability of CNM-adsorbed contaminants is still limited. To investigate the influence of CNM morphology and organic contaminant (OC) physicochemical properties on this relationship, adsorption isotherms were generated for a suite of polycyclic aromatic hydrocarbons (PAHs) on multi-walled carbon nanotubes (MWCNTs) and exfoliated graphene (GN) in conjunction with determining the bioavailability of the adsorbed PAHs to Pimphales promelas using bile analysis via fluorescence spectroscopy...
July 12, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28687535/endothelial-nf-%C3%AE%C2%BAb-blockade-abrogates-anca-induced-gn
#13
Mira Choi, Adrian Schreiber, Claudia Eulenberg-Gustavus, Claus Scheidereit, Jan Kamps, Ralph Kettritz
ANCA-associated vasculitis (AAV) is a highly inflammatory condition in which ANCA-activated neutrophils interact with the endothelium, resulting in necrotizing vasculitis. We tested the hypothesis that endothelial NF-κB mediates necrotizing crescentic GN (NCGN) and provides a specific treatment target. Reanalysis of kidneys from previously examined murine NCGN disease models revealed NF-κB activation in affected kidneys, mostly as a p50/p65 heterodimer, and increased renal expression of NF-κB-dependent tumor necrosis factor α (TNF-α)...
July 7, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28676642/label-free-detection-of-sensitive-mid-infrared-biomarkers-of-glomerulonephritis-in-urine-using-fourier-transform-infrared-spectroscopy
#14
Mei-Ching Yu, Peter Rich, Liberty Foreman, Jennifer Smith, Mei-Shiuan Yu, Anisha Tanna, Vinod Dibbur, Robert Unwin, Frederick W K Tam
More reliable biomarkers using near-patient technologies are needed to improve early diagnosis and intervention for patients with renal disease. Infrared (IR) vibrational spectroscopy/microspectroscopy is an established analytical method that was first used in biomedical research over 20 years ago. With the advances in instrumentation, computational and mathematical techniques, this technology has now been applied to a variety of diseases; however, applications in nephrology are just beginning to emerge. In the present study, we used attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy to analyze urine samples collected from rodent models of inflammatory glomerulonephritis (GN) as well as from patients with crescentic GN, with the aim of identifying potential renal biomarkers; several characteristic mid-IR spectral markers were identified in urine samples...
July 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28667079/decreased-expression-of-connexin-43-blunts-the-progression-of-experimental-gn
#15
Panagiotis Kavvadas, Ahmed Abed, Coralie Poulain, Florence Authier, Lise-Paule Labéjof, Amelie Calmont, Carlo Afieri, Niki Prakoura, Jean-Claude Dussaule, Christos Chatziantoniou, Christos E Chadjichristos
GN refers to a variety of renal pathologies that often progress to ESRD, but the molecular mechanisms underlying this progression remain incompletely characterized. Here, we determined whether dysregulated expression of the gap junction protein connexin 43, which has been observed in the progression of renal disease, contributes to GN progression. Immunostaining revealed de novo expression of connexin 43 in damaged glomeruli in patients with glomerular diseases as well as in mice after induction of experimental GN...
June 30, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28663230/tissue-specific-microrna-expression-patterns-in-four-types-of-kidney-disease
#16
Maria Angeles Baker, Seth J Davis, Pengyuan Liu, Xiaoqing Pan, Anna Marie Williams, Kenneth A Iczkowski, Sean T Gallagher, Kaylee Bishop, Kevin R Regner, Yong Liu, Mingyu Liang
MicroRNAs contribute to the development of kidney disease. Previous analyses of microRNA expression in human kidneys, however, were limited by tissue heterogeneity or the inclusion of only one pathologic type. In this study, we used laser-capture microdissection to obtain glomeruli and proximal tubules from 98 human needle kidney biopsy specimens for microRNA expression analysis using deep sequencing. We analyzed specimens from patients with diabetic nephropathy (DN), FSGS, IgA nephropathy (IgAN), membranoproliferative GN (MPGN) (n=19-23 for each disease), and a control group (n=14)...
June 29, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28659624/alcohol-recognition-by-flexible-transparent-and-highly-sensitive-graphene-based-thin-film-sensors
#17
Xuezhu Xu, Jian Zhou, Yangyang Xin, Gilles Lubineau, Qian Ma, Long Jiang
Chemical sensors detect a variety of chemicals across numerous fields, such as automobile, aerospace, safety, indoor air quality, environmental control, food, industrial production and medicine. We successfully assemble an alcohol-sensing device comprising a thin-film sensor made of graphene nanosheets (GNs) and bacterial cellulose nanofibers (BCNs). We show that the GN/BCN sensor has a high selectivity to ethanol by distinguishing liquid-phase or vapor-phase ethanol (C2H6O) from water (H2O) intelligently with accurate transformation into electrical signals in devices...
June 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28658335/invasive-ductal-carcinoma-relationship-between-pathological-characteristics-and-the-presence-of-axillary-metastasis-in-220-cases
#18
Ranniere Gurgel Furtado DE Aquino, Paulo Henrique Diógenes Vasques, Diane Isabelle Magno Cavalcante, Ayane Layne DE Sousa Oliveira, Bruno Masato Kitagawa DE Oliveira, Luiz Gonzaga Porto Pinheiro
Objective: to analyze the relation of anatomopathological features and axillary involvement in cases of invasive ductal carcinoma. Methods: this is a cross-sectional study of 220 breast cancer patients submitted to radical mastectomy or quadrantectomy with axilar emptying, from the Mastology Service of the Assis Chateaubriand Maternity School, Ceará, Brazil. We submitted the tumors to histological processing and determined the histological (HG), tubular (TG) and nuclear (NG) grades, and the mitotic index (MI) by the classification of Scarff-Bloom-Richadson, verified the presence of angiolymphatic invasion (AI) and measured the largest tumor diameter (TD)...
March 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28657343/diagnostic-reliability-of-mandibular-second-molar-maturation-in-the-identification-of-the-mandibular-growth-peak-a-longitudinal-study
#19
Giuseppe Perinetti, Riccardo Sossi, Jasmina Primozic, Gaetano Ierardo, Luca Contardo
OBJECTIVE: To investigate the diagnostic reliability of mandibular second molar maturation in assessing the mandibular growth peak using a longitudinal design. MATERIALS AND METHODS: From the files of the Burlington and Oregon growth studies, 40 subjects (20 from each collection, 20 males and 20 females) with at least seven annual lateral cephalograms taken from 9 to 16 years were included. Mandibular second molar maturation was assessed according to Demirjian et al...
June 28, 2017: Angle Orthodontist
https://www.readbyqxmd.com/read/28648620/iron-overload-induces-hypogonadism-in-male-mice-via-extrahypothalamic-mechanisms
#20
Chiara Macchi, Liliana Steffani, Roberto Oleari, Antonella Lettieri, Luca Valenti, Paola Dongiovanni, Antonio Romero-Ruiz, Manuel Tena-Sempere, Anna Cariboni, Paolo Magni, Massimiliano Ruscica
INTRODUCTION: Iron overload leads to multiple organ damage including endocrine organ dysfunctions. Hypogonadism is the most common non-diabetic endocrinopathy in primary and secondary iron overload syndromes. AIM: To explore the molecular determinants of iron overload-induced hypogonadism with specific focus on hypothalamic derangements. A dysmetabolic male murine model fed iron-enriched diet (IED) and cell-based models of gonadotropin-releasing hormone (GnRH) neurons were used...
June 22, 2017: Molecular and Cellular Endocrinology
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