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https://www.readbyqxmd.com/read/28548144/metal-free-spin-and-spin-gapless-semiconducting-heterobilayers-monolayer-boron-carbonitrides-on-hexagonal-boron-nitride
#1
Hongzhe Pan, Hongyu Zhang, Yuanyuan Sun, Yingchun Ding, Jie Chen, Youwei Du, Nujiang Tang
The interfaces between monolayer boron carbonitrides and hexagonal boron nitride (h-BN) play an important role in their practical applications. Herein, we respectively investigate the structural and electronic properties of two metal-free heterobilayers constructed by vertically stacking two-dimensional (2D) spintronic materials (B4CN3 and B3CN4) on a h-BN monolayer from the viewpoints of lattice match and lattice mismatch models using density functional calculations. It is found that both B4CN3 and B3CN4 monolayers can be stably adsorbed on the h-BN monolayer due to the van der Waals interactions...
May 26, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28545229/an-iterative-distortion-compensation-algorithm-for-camera-calibration-based-on-phase-target
#2
Yongjia Xu, Feng Gao, Hongyu Ren, Zonghua Zhang, Xiangqian Jiang
Camera distortion is a critical factor affecting the accuracy of camera calibration. A conventional calibration approach cannot satisfy the requirement of a measurement system demanding high calibration accuracy due to the inaccurate distortion compensation. This paper presents a novel camera calibration method with an iterative distortion compensation algorithm. The initial parameters of the camera are calibrated by full-field camera pixels and the corresponding points on a phase target. An iterative algorithm is proposed to compensate for the distortion...
May 23, 2017: Sensors
https://www.readbyqxmd.com/read/28544855/descriptive-study-of-relationship-between-cardio-ankle-vascular-index-and-biomarkers-in-vascular-related-diseases
#3
Jinbo Liu, Huan Liu, Hongwei Zhao, Guangyun Shang, Yingyan Zhou, Lihong Li, Hongyu Wang
BACKGROUND: Cardio-ankle vascular index (CAVI) was supposed to be an independent predictor for vascular-related events. Biomarkers such as homocysteine (Hcy), N-terminal pro-brain natriuretic peptide (NT-proBNP), and urine albumin(microalbumin) (UAE) have involved the pathophysiological development of arteriosclerosis. The present study was to investigate relationship between CAVI and biomarkers in vascular-related diseases. METHODS: A total of 656 subjects (M/F 272/384) from department of Vascular Medicine were enrolled into our study...
May 25, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28539044/the-effect-of-resveratrol-on-modulation-of-endothelial-cells-and-macrophages-for-rapid-vascular-regeneration-from-electrospun-poly-%C3%AE%C2%B5-caprolactone-scaffolds
#4
Zhihong Wang, Yifan Wu, Jianing Wang, Chuangnian Zhang, Hongyu Yan, Meifeng Zhu, Kai Wang, Chen Li, Qingbo Xu, Deling Kong
Rapid endothelialization is one key factor that determines the success of small diameter vascular grafts as an artery substitute in the treatment of cardiovascular disease. Aimed to facilitate vascular regeneration, we developed a vascular scaffold loaded with resveratrol, which is a natural compound extracted from plants and showed multifaceted effects in cardiovascular protection. The tubular poly (ε-caprolactone) (PCL) scaffold was prepared by electrospinning with resveratrol in the PCL solution. In vitro assay demonstrated that resveratrol could be released from the scaffolds in a sustained and controlled manner...
May 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28537380/a-dna-tetrahedron-nanoprobe-with-controlled-distance-of-dyes-for-multiple-detection-in-living-cells-and-in-vivo
#5
Na Li, Meimei Wang, Xiaonan Gao, Zhengze Yu, Wei Pan, Hongyu Wang, Bo Tang
Multicomponent quantitative detection in living samples is becoming increasingly important, however, the current detection strategy may cause fluorescence self-quenching and reduce the sensitivity of detection. To solve the problem, we develop a DNA tetrahedral nanoprobe to control the dyes distance for simultaneous detection of multiple analytes. Compared to mesoporous silica nanoparticles based nanoprobes, the DNA tetrahedral nanoprobes display enhanced fluorescence intensities due to partially avoiding the fluorescence resonance energy transfer...
May 24, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28536426/toll-like-receptor-4-mediates-lewis-lung-carcinoma-induced-muscle-wasting-via-coordinate-activation-of-protein-degradation-pathways
#6
Guohua Zhang, Zhelong Liu, Hui Ding, Hongyu Miao, Jose M Garcia, Yi-Ping Li
Cancer-induced cachexia, characterized by muscle wasting, is a lethal metabolic syndrome with undefined etiology. Current consensus is that multiple factors contribute to cancer-induced muscle wasting, and therefore therapy requires combinational strategies. Here, we show that Toll-like receptor 4 (TLR4) mediates cancer-induced muscle wasting by directly activating muscle catabolism as well as stimulating an innate immune response in mice bearing Lewis lung carcinoma (LLC), and targeting TLR4 alone effectively abrogate muscle wasting...
May 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28536141/melk-and-ezh2-cooperate-to-regulate-medulloblastoma-cancer-stem-like-cell-proliferation-and-differentiation
#7
Hailong Liu, Qianwen Sun, Youliang Sun, Junping Zhang, Hongyu Yuan, Shuhuan Pang, Xueling Qi, Haoran Wang, Mingshan Zhang, Honwei Zhang, Chunjiang Yu, Chunyu Gu
Medulloblastoma is the most common malignant brain tumor in children. Although accumulated research has suggested that cancer stem-like cells play a key role in medulloblastoma tumorigenesis, the specific molecular mechanism regarding proliferation remains elusive. Here, we reported that more abundant expression of maternal embryonic leucine-zipper kinase (MELK) and enhancer of zeste homolog 2 (EZH2) in medulloblastoma stem-like cells than in neural stem cells and the interaction between the two proteins could mediate the self-renewal of sonic hedgehog (SHH)-subtype medulloblastoma...
May 23, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28532538/-aberrant-expression-of-rb-and-prb-780-prb-795-in-lung-adenocarcinoma-patients-with-egfr-mutations-and-their-clinical-significance
#8
Yunlong Dong, Minghui Liu, Yongwen Li, Ying Li, Chenlong Zhao, Yin Yuan, Hui Du, Zihe Zhang, Hongbing Zhang, Hongyu Liu, Jun Chen
BACKGROUND: Rb is an important tumor suppressor gene that regulates cell cycle progression. Rb dysfunction can lead to over proliferation of cells and lead to the occurrence of tumor. Loss or reduced Rb expression as well as over phosphorylation of Rb are important mechanisms of Rb dysfunction. The mutated epidermal growth factor receptor (EGFR) gene is an important driver gene in lung adenocarcinoma, and plays an important role in the development of lung cancer. The purpose of this study was to investigate the status of Rb in lung adenocarcinoma patients with EGFR mutations and define the clinicopathologic features...
May 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28532516/properties-of-realgar-bioleaching-using-an-extremely-acidophilic-bacterium-and-its-antitumor-mechanism-as-an-anticancer-agent
#9
REVIEW
Peng Chen, Ruixiang Xu, Lei Yan, Zhengrong Wu, Yan Wei, Wenbin Zhao, Xin Wang, Qinjian Xie, Hongyu Li
Realgar is a naturally occurring arsenic sulfide (or Xionghuang, in Chinese). It contains over 90% tetra-arsenic tetra-sulfide (As4S4). Currently, realgar has been confirmed the antitumor activities, both in vitro and in vivo, of realgar extracted using Acidithiobacillus ferrooxidans (A. ferrooxidans). Bioleaching, a new technology to greatly improve the use rate of arsenic extraction from realgar using bacteria, is a novel methodology that addressed a limitation of the traditional method for realgar preparation...
May 22, 2017: Biological Research
https://www.readbyqxmd.com/read/28529645/tumor-penetrating-theranostic-nanoparticles-for-enhancement-of-targeted-and-image-guided-drug-delivery-into-peritoneal-tumors-following-intraperitoneal-delivery
#10
Ning Gao, Erica N Bozeman, Weiping Qian, Liya Wang, Hongyu Chen, Malgorzata Lipowska, Charles A Staley, Y Andrew Wang, Hui Mao, Lily Yang
The major obstacles in intraperitoneal (i.p.) chemotherapy of peritoneal tumors are fast absorption of drugs into the blood circulation, local and systemic toxicities, inadequate drug penetration into large tumors, and drug resistance. Targeted theranostic nanoparticles offer an opportunity to enhance the efficacy of i.p. therapy by increasing intratumoral drug delivery to overcome resistance, mediating image-guided drug delivery, and reducing systemic toxicity. Herein we report that i.p. delivery of urokinase plasminogen activator receptor (uPAR) targeted magnetic iron oxide nanoparticles (IONPs) led to intratumoral accumulation of 17% of total injected nanoparticles in an orthotopic mouse pancreatic cancer model, which was three-fold higher compared with intravenous delivery...
2017: Theranostics
https://www.readbyqxmd.com/read/28507174/elevated-adenosine-induces-placental-dna-hypomethylation-independent-of-a2b-receptor-signaling-in-preeclampsia
#11
Aji Huang, Hongyu Wu, Takayuki Iriyama, Yujin Zhang, Kaiqi Sun, Anren Song, Hong Liu, Zhangzhe Peng, Lili Tang, Minjung Lee, Yun Huang, Xin Ni, Rodney E Kellems, Yang Xia
Preeclampsia is a prevalent pregnancy hypertensive disease with both maternal and fetal morbidity and mortality. Emerging evidence indicates that global placental DNA hypomethylation is observed in patients with preeclampsia and is linked to altered gene expression and disease development. However, the molecular basis underlying placental epigenetic changes in preeclampsia remains unclear. Using 2 independent experimental models of preeclampsia, adenosine deaminase-deficient mice and a pathogenic autoantibody-induced mouse model of preeclampsia, we demonstrate that elevated placental adenosine not only induces hallmark features of preeclampsia but also causes placental DNA hypomethylation...
May 15, 2017: Hypertension
https://www.readbyqxmd.com/read/28490754/effect-of-alkaline-microwaving-pretreatment-on-anaerobic-digestion-and-biogas-production-of-swine-manure
#12
Tao Yu, Yihuan Deng, Hongyu Liu, Chunping Yang, Bingwen Wu, Guangming Zeng, Li Lu, Fumitake Nishimura
Microwave assisted with alkaline (MW-A) condition was applied in the pretreatment of swine manure, and the effect of the pretreatment on anaerobic treatment and biogas production was evaluated in this study. The two main microwaving (MW) parameters, microwaving power and reaction time, were optimized for the pretreatment. Response surface methodology (RSM) was used to investigate the effect of alkaline microwaving process for manure pretreatment at various values of pH and energy input. Results showed that the manure disintegration degree was maximized of 63...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28490583/structural-definition-of-duck-mhc-class-i-molecules-that-might-explain-efficient-ctl-immunity-against-influenza-a-virus
#13
Yanan Wu, Junya Wang, Shuhua Fan, Rong Chen, Yanjie Liu, Jianhua Zhang, Hongyu Yuan, Ruiying Liang, Nianzhi Zhang, Chun Xia
A single dominantly expressed allele of the major histocompatibility complex class I (MHC I) may be responsible for the duck's high tolerance to the highly pathogenic (HP) influenza A virus (IAV) compared to the chicken's lower tolerance. In this study, the crystal structures of duck MHC I (Anpl-UAA*01) and duck β2m with two peptides from the H5N1 strains were determined, respectively. Two remarkable features were found to distinguish the Anpl-UAA*01 complex from other known MHC I structures. A disulfide bond formed by Cys(95) and Cys(112) and connecting the β5 and β6 sheets at the bottom of peptide binding groove (PBG) in Anpl-UAA*01 complex, which can enhance IAV peptides binding, was identified...
May 10, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28489411/gcoda-conditional-dependence-network-inference-for-compositional-data
#14
Huaying Fang, Chengcheng Huang, Hongyu Zhao, Minghua Deng
The increasing quality and the reducing cost of high-throughput sequencing technologies for 16S rRNA gene profiling enable researchers to directly analyze microbe communities in natural environments. The direct interactions among microbial species of a given ecological system can help us understand the principles of community assembly and maintenance under various conditions. Compositionality and dimensionality of microbiome data are two main challenges for inferring the direct interaction network of microbes...
May 10, 2017: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/28481022/stepwise-crosslinking-a-facile-yet-versatile-conceptual-strategy-to-nanomorphology-persistent-porous-organic-polymers
#15
Hao Liu, Shimei Li, Hongyu Yang, Shaohong Liu, Luyi Chen, Zhiwei Tang, Ruowen Fu, Dingcai Wu
Both high surface areas and well-orchestrated nanomorphologies are important for porous organic polymers (POPs). However, the two key characteristics are generally difficult to be satisfied simultaneously, because the common pore-making procedures usually produce ill-defined nanomorphologies or give rise to damage of precustomized nanomorphologies. Herein, a facile yet versatile stepwise crosslinking strategy for fabrication of POPs with an unusual nanomorphology-persistent characteristic during pore-making is reported...
May 8, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28473666/the-palmitoylation-of-the-n-terminal-extracellular-cys37-mediates-the-nuclear-translocation-of-vpac1-contributing-to-its-anti-apoptotic-activity
#16
Rongjie Yu, Hongyu Liu, Xinhe Peng, Yue Cui, Suqin Song, Like Wang, Huahua Zhang, An Hong, Tianhong Zhou
VPAC1 is class B G protein-coupled receptors (GPCR) shared by pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP). The first cysteine (Cys37) in the N-terminal extracellular domain of mature VPAC1 is a free Cys not involved in the formation of conserved intramolecular disulfide bonds. In order to investigate the biological role of this Cys37 in VPAC1, the wild-type VPAC1 and Cys37/Ala mutant (VPAC1-C37/A) were expressed stably as fusion proteins with enhanced yellow fluorescent protein (EYFP) respectively in Chinese hamster ovary (CHO) cells...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28472965/parameter-identifiability-based-optimal-observation-remedy-for-biological-networks
#17
Yulin Wang, Hongyu Miao
BACKGROUND: To systematically understand the interactions between numerous biological components, a variety of biological networks on different levels and scales have been constructed and made available in public databases or knowledge repositories. Graphical models such as structural equation models have long been used to describe biological networks for various quantitative analysis tasks, especially key biological parameter estimation. However, limited by resources or technical capacities, partial observation is a common problem in experimental observations of biological networks, and it thus becomes an important problem how to select unobserved nodes for additional measurements such that all unknown model parameters become identifiable...
May 4, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/28465571/upconversion-modulation-through-pulsed-laser-excitation-for-anti-counterfeiting
#18
Yingdong Han, Hongyu Li, Yangbo Wang, Yue Pan, Ling Huang, Feng Song, Wei Huang
Lanthanide-doped upconversion nanomaterials are emerging as promising candidates in optoelectronics, volumetric display, anti-counterfeiting as well as biological imaging and therapy. Typical modulations of upconversion through chemical methods, such as controlling phase, composition, morphology and size enable us to rationally manipulate emission profiles and lifetimes of lanthanide ions by using continuous-wave laser excitation. Here we demonstrate that under pulsed laser excitation the emission color of NaYF4:Er/Tm (2/0...
May 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28459196/relationships-of-mmp-9-e-cadherin-and-vegf-expression-with-clinicopathological-features-and-response-to-chemosensitivity-in-gastric-cancer
#19
Hongyu Gao, Xiuwen Lan, Sen Li, Yingwei Xue
The matrix metalloproteinase-9, E-cadherin, and vascular endothelial growth factor play an important role in behavior of tumor cell growth, invasion, and metastasis. In this study, we investigated the relationships of matrix metalloproteinase-9, E-cadherin, and vascular endothelial growth factor expression with clinicopathological features and results of chemosensitivity tested by collagen gel droplet-embedded culture-drug sensitivity test in gastric cancer. Fresh specimens were used for collagen gel droplet-embedded culture-drug sensitivity test and paired fixed specimens were used for immunohistochemistry...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28457943/actin-cytoskeleton-mediates-bmp2-smad-signaling-via-calponin-1-in-preosteoblast-under-simulated-microgravity
#20
Hongjie Xu, Feng Wu, Hongyu Zhang, Chao Yang, Kai Li, Hailong Wang, Honghui Yang, Yue Liu, Bai Ding, Yingjun Tan, Ming Yuan, Yinghui Li, Zhongquan Dai
Microgravity influences the activity of osteoblast, induces actin microfilament disruption and leads to bone loss during spaceflight. Mechanical stress such as gravity, regulates cell function, response and differentiation through dynamic cytoskeleton changes, but the mechanotransduction mechanism remains to be fully elucidated. Previous, we demonstrated actin microfilament mediated osteoblast Cbfa1 responsiveness to BMP2 under simulated microgravity (SMG). Here, we explored a potential molecular and its detailed mechanism of actin cytoskeleton functioning on BMP2-Smad signaling in MC3T3-E1 under SMG...
April 27, 2017: Biochimie
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