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https://www.readbyqxmd.com/read/28069536/m2-macrophages-infusion-ameliorates-obesity-and-insulin-resistance-by-remodeling-inflammatory-macrophages-homeostasis-in-obese-mice
#1
Qi Zhang, Haojie Hao, Zongyan Xie, Yu Cheng, Yaqi Yin, Min Xie, Hong Huang, Jieqing Gao, Hongyu Liu, Chuan Tong, Li Zang, Yiming Mu, Weidong Han
OBJECTIVE: The role of M2 macrophages infusion in dealing with obesity is still little known. In this study, the therapeutic effects of M2 macrophages infusion were investigated. METHODS: High fat diet (HFD) was used to induce obesity in C57BL/6N mice. 5 × 10(5) M2 macrophages, derived from the bone marrow, were injected into obese mice through the tail vein twice with an interval of one week. RESULTS: One week after the second injection, weight of inguinal adipose pad was significantly decreased...
January 6, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28069363/adolescent-booster-with-hepatitis-b-virus-vaccines-decreases-hbv-infection-in-high-risk-adults
#2
Yuting Wang, Taoyang Chen, Ling-Ling Lu, Minjie Wang, Dongmei Wang, Hongyu Yao, Chunsun Fan, Jun Qi, Yawei Zhang, Chunfeng Qu
BACKGROUND: Neutralizing antibodies (anti-HBs) after immunization with hepatitis B virus (HBV) vaccines against HBV surface antigen (HBsAg) wane after 10-15years. We analyzed the effect of an adolescent booster given to vaccination-protected children born to mothers with different HBsAg-carrying status against HBV infection in their mature adulthood. METHODS: A total of 9793 individuals, who were HBsAg-negative at childhood (baseline) and donated blood samples, both during childhood and adulthood, from the vaccination group in "Qidong Hepatitis B Intervention Study", were enrolled...
January 6, 2017: Vaccine
https://www.readbyqxmd.com/read/28060542/puerarin-protects-against-endothelial-dysfunction-and-end-organ-damage-in-ang-ii-induced-hypertension
#3
Xiaojie Li, Yuhan Lin, Hongyu Zhou, Yao Li, Aimei Wang, Hongxin Wang, Ming-Sheng Zhou
Puerarin, a major isoflavonoid compound from Chinese herb Kudzu roots, has been widely used for the treatment of hypertensive and cardiovascular diseases in China. Here, we investigated puerarin's beneficial effects on the cardiovascular system in angiotensin (Ang) II-induced hypertensive rats. Sprague-Dawley rats were treated with Ang II for 5 days or with puerarin for 10 days followed by Ang II and puerarin for 5 days. Endothelium-dependent relaxation (EDR) to acetylcholine was determined using an organ chamber bath...
January 6, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28059160/low-temperature-remote-plasma-enhanced-atomic-layer-deposition-of-zro2-zircone-nanolaminate-film-for-efficient-encapsulation-of-flexible-organic-light-emitting-diodes
#4
Zheng Chen, Haoran Wang, Xiao Wang, Ping Chen, Yunfei Liu, Hongyu Zhao, Yi Zhao, Yu Duan
Encapsulation is essential to protect the air-sensitive components of organic light-emitting diodes (OLEDs) such as active layers and cathode electrodes. In this study, hybrid zirconium inorganic/organic nanolaminates were fabricated using remote plasma enhanced atomic layer deposition (PEALD) and molecular layer deposition at a low temperature. The nanolaminate serves as a thin-film encapsulation layer for OLEDs. The reaction mechanism of PEALD process was investigated using an in-situ quartz crystal microbalance (QCM) and in-situ quadrupole mass spectrometer (QMS)...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28056372/methanogenic-degradation-of-toilet-paper-cellulose-upon-sewage-treatment-in-an-anaerobic-membrane-bioreactor-at-room-temperature
#5
Rong Chen, Yulun Nie, Hiroyuki Kato, Jiang Wu, Tetsuya Utashiro, Jianbo Lu, Shangchao Yue, Hongyu Jiang, Lu Zhang, Yu-You Li
Toilet-paper cellulose with rich but refractory carbon sources, are the main insoluble COD fractions in sewage. An anaerobic membrane bioreactor (AnMBR) was configured for sewage treatment at room temperature and its performance on methanogenic degradation of toilet paper was highlighted. The results showed, high organic removal (95%), high methane conversion (90%) and low sludge yield (0.08gVSS/gCOD) were achieved in the AnMBR. Toilet-paper cellulose was fully biodegraded without accumulation in the mixed liquor and membrane cake layer...
December 25, 2016: Bioresource Technology
https://www.readbyqxmd.com/read/28056074/application-of-gelgreen%C3%A2-in-cesium-chloride-density-gradients-for-dna-stable-isotope-probing-experiments
#6
Jingfeng Gao, Kailing Pan, Hongyu Li, Xiaoyan Fan, Lixin Sun, Shujun Zhang, Yongqing Gao
In this study, GelGreen™ was investigated as a replacement for SYBR® Safe to stain DNA in cesium chloride (CsCl) density gradients for DNA-stable isotope probing (SIP) experiments. Using environmental DNA, the usage of GelGreen™ was optimized for sensitivity compared to SYBR® Safe, its optimal concentration, detection limit for environmental DNA and its application in environmental DNA-SIP assay. Results showed that GelGreen™ was more sensitive than SYBR® Safe, while the optimal dosage (15X concentration) needed was approximately one-third of SYBR® Safe, suggesting that its sensitivity was three times more superior than SYBR® Safe...
2017: PloS One
https://www.readbyqxmd.com/read/28045500/transport-in-a-single-self-doped-nanocrystal
#7
Hongyue Wang, Emmanuel Lhuillier, Qian Yu, Alexandre Zimmers, Benoit Dubertret, Christian Ulysse, Herve Aubin
Addressing the optical properties of a single nanoparticle in the infrared is particularly challenging, thus alternative methods for characterizing the conductance spectrum of nanoparticles in this spectral range need to be developed. Here we describe an efficient method of fabricating single nanoparticle tunnel junctions on a chip circuit. We apply this method to narrow band gap nanoparticles of HgSe, which band structure combine the inverted character of the bulk semimetal with quantum confinement and self-doping...
January 3, 2017: ACS Nano
https://www.readbyqxmd.com/read/28035418/realgar-transforming-solution-displays-anticancer-potential-against-human-hepatocellular-carcinoma-hepg2-cells-by-inducing-ros
#8
Peng Song, Peng Chen, Dong Wang, Zhengrong Wu, Qiyu Gao, Aixia Wang, Ruilan Zhu, Yajun Wang, Xin Wang, Longhe Zhao, Ziyun Duan, Shuqian Zhu, Peng Cui, Yang Li, Hongyu Li
Realgar (As4S4), as a mineral drug containing arsenic compound, has been employed in clinical therapy of cancer for its good therapeutic reputation in Chinese traditional medicine. However, large dose of realgar and long period of treatment are necessary for achieving the effective blood medicine concentration due to its low bioavailability resulted from poor solubility. In this study, we obtained realgar transforming solution (RTS) using intrinsic biotransformation in microorganism, and investigated underlying mechanisms of RTS for HepG2 cells...
December 30, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/28019059/impact-of-genotyping-errors-on-statistical-power-of-association-tests-in-genomic-analyses-a-case-study
#9
Lin Hou, Ning Sun, Shrikant Mane, Fred Sayward, Nallakkandi Rajeevan, Kei-Hoi Cheung, Kelly Cho, Saiju Pyarajan, Mihaela Aslan, Perry Miller, Philip D Harvey, J Michael Gaziano, John Concato, Hongyu Zhao
A key step in genomic studies is to assess high throughput measurements across millions of markers for each participant's DNA, either using microarrays or sequencing techniques. Accurate genotype calling is essential for downstream statistical analysis of genotype-phenotype associations, and next generation sequencing (NGS) has recently become a more common approach in genomic studies. How the accuracy of variant calling in NGS-based studies affects downstream association analysis has not, however, been studied using empirical data in which both microarrays and NGS were available...
December 26, 2016: Genetic Epidemiology
https://www.readbyqxmd.com/read/28018679/activation-of-sphingosine-1-phosphate-receptor-1-enhances-hippocampus-neurogenesis-in-a-rat-model-of-traumatic-brain-injury-an-involvement-of-mek-erk-signaling-pathway
#10
Yuqin Ye, Zhenyu Zhao, Hongyu Xu, Xin Zhang, Xinhong Su, Yongxiang Yang, Xinguang Yu, Xiaosheng He
Among sphingosine 1-phosphate receptors (S1PRs) family, S1PR1 has been shown to be the most highly expressed subtype in neural stem cells (NSCs) and plays a crucial role in the migratory property of NSCs. Recent studies suggested that S1PR1 was expressed abundantly in the hippocampus, a specific neurogenic region in rodent brain for endogenous neurogenesis throughout life. However, the potential association between S1PR1 and neurogenesis in hippocampus following traumatic brain injury (TBI) remains unknown...
2016: Neural Plasticity
https://www.readbyqxmd.com/read/28009010/structural-insights-on-pha-binding-protein-phap-from-aeromonas-hydrophila
#11
Hongyu Zhao, Hui Wei, Xi Liu, Zhenyu Yao, Manyu Xu, Daixu Wei, Jiawei Wang, Xinquan Wang, Guo-Qiang Chen
Phasins or PhaPs are a group of amphiphilic proteins that are found attached to the surface of microbial polyhydroxyalkanoate (PHA) granules. They have both structural and regulatory functions and can affect intracellular PHA accumulation and mediate protein folding. The molecular basis for the diverse functions of the PhaPs has not been fully understood due to the lack of the structural knowledge. Here we report the structural and biochemical studies of the PhaP cloned from Aeromonas hydrophila (PhaPAh), which is utilized in protein and tissue engineering...
December 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28002735/characterization-of-the-folding-of-a-52-knotted-protein-using-engineered-single-tryptophan-variants
#12
Hongyu Zhang, Sophie E Jackson
An increasing number of proteins that contain topological knots have been identified over the past two decades; however, their folding mechanisms are still not well understood. UCH-L1 has a 52-knotted topology. Here, we constructed a series of variants that contain a single tryptophan at different locations along the polypeptide chain. A study of the thermodynamic properties of the variants shows that the structure of UCH-L1 is remarkably tolerant to incorporation of bulky tryptophan side chains. Comprehensive kinetic studies of the variants reveal that they fold via parallel pathways on which there are two intermediate states very similar to wild-type UCH-L1...
December 20, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/28000591/relative-importance-of-meteorological-and-geographical-factors-in-the-distribution-of-fasciola-hepatica-infestation-in-farmed-sheep-in-qinghai-province-china
#13
Hongyu Qin, Xiang Gao, Hongbin Wang, Jianhua Xiao
Fasciola hepatica is an important trematode parasite of economic importance that infests sheep and cattle worldwide. We conducted a detailed investigation into the spatial distribution of F. hepatica infestation in farmed sheep in Qinghai (Wutumeiren) province, Mainland China. Mathematical modelling was used to assess the inter-relationships between meteorological and geographical factors and the risk of F. hepatica infestation across the province. A capture enzyme-linked immunosorbent assay (ELISA) test (MM3-SERO) was used to detect F...
2016: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/27999203/serine-protease-inhibitor-kazal-type-6-inhibits-tumorigenesis-of-human-hepatocellular-carcinoma-cells-via-its-extracellular-action
#14
Kuikui Ge, Jinjiang Huang, Wei Wang, Meigang Gu, Xinchuan Dai, Yuqiang Xu, Hongyu Wu, Guodong Li, Hairong Lu, Jiang Zhong, Qingshan Huang
Hepatocellular carcinoma (HCC) causes significant medical burdens worldwide. Diagnosis, especially in the early stages, is still challenging. Therapeutic options are limited and often ineffective. Although several risk factors have been known important for development of HCC, the molecular basis of the process is rather complex and has not been fully understood. We have found that a subpopulation of HCC cells which are resistant to oncolytic parvovirus H1 superinfection highly express serine protease inhibitor Kazal-type 6 (SPINK6)...
December 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27994610/genome-wide-analysis-of-soybean-jmjc-domain-containing-proteins-suggests-evolutionary-conservation-following-whole-genome-duplication
#15
Yapeng Han, Xiangyong Li, Lin Cheng, Yanchun Liu, Hui Wang, Danxia Ke, Hongyu Yuan, Liangsheng Zhang, Lei Wang
Histone modifications, such as methylation and demethylation, play an important role in regulating chromatin structure and gene expression. The JmjC domain-containing proteins, an important family of histone lysine demethylases (KDMs), play a key role in maintaining homeostasis of histone methylation in vivo. In this study, we performed a comprehensive analysis of the jumonji C (JmjC) gene family in the soybean genome and identified 48 JmjC genes (GmJMJs) distributed unevenly across 18 chromosomes. Phylogenetic analysis showed that these JmjC domain-containing genes can be divided into eight groups...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27993351/mesenchymal-stem-cells-overexpressing-il-35-effectively-inhibit-cd4-t-cell-function
#16
Na Zhao, Hongyue Li, Yongjia Yan, Ruoyu Jiang, Xianghui He
Mesenchymal stem cells (MSCs) have recently emerged as promising candidates for cell-based immune tolerance therapy. Interleukin 35 (IL-35) is a relatively newly identified cytokine required for the regulatory and suppressive functions of regulatory T cells (Treg), playing an important role in the prevention of autoimmune diseases. In this study, we isolated adipose tissue-derived MSCs, a good vehicle for cell therapy, which were transfected with a lentivirus vector for the overexpression of the therapeutic murine IL-35 gene...
December 8, 2016: Cellular Immunology
https://www.readbyqxmd.com/read/27990759/the-toxicity-of-flonicamid-to-cotton-leafhopper-amrasca-biguttula-ishida-is-by-disruption-of-ingestion-an-epg-study
#17
Kaleem Tariq, Mah Noor, Elaine A Backus, Adil Hussain, Asad Ali, Wei Peng, Hongyu Zhang
BACKGROUND: The cotton leafhopper, Amrasca biguttula, is one of the most destructive pests of cotton in Asia. This species is thought to cause damage by injecting enzymatic saliva into various, presently unknown, cotton tissues and ingesting the resulting macerate. Flonicamid is a novel systemic insecticide used to control the cotton leafhopper however, its mode of action is unknown. RESULTS: The mechanism of action of flonicamid on cotton leafhopper was investigated using electropenetrography (EPG)...
December 19, 2016: Pest Management Science
https://www.readbyqxmd.com/read/27988322/a-multi-centre-evaluation-of-eleven-clinically-feasible-brain-pet-mri-attenuation-correction-techniques-using-a-large-cohort-of-patients
#18
Claes N Ladefoged, Ian Law, Udunna Anazodo, Keith St Lawrence, David Izquierdo-Garcia, Ciprian Catana, Ninon Burgos, M Jorge Cardoso, Sebastien Ourselin, Brian Hutton, Inés Mérida, Nicolas Costes, Alexander Hammers, Didier Benoit, Søren Holm, Meher Juttukonda, Hongyu An, Jorge Cabello, Mathias Lukas, Stephan Nekolla, Sibylle Ziegler, Matthias Fenchel, Bjoern Jakoby, Michael E Casey, Tammie Benzinger, Liselotte Højgaard, Adam E Hansen, Flemming L Andersen
AIM: To accurately quantify the radioactivity concentration measured by PET, emission data need to be corrected for photon attenuation; however, the MRI signal cannot easily be converted into attenuation values, making attenuation correction (AC) in PET/MRI challenging. In order to further improve the current vendor-implemented MR-AC methods for absolute quantification, a number of prototype methods have been proposed in the literature. These can be categorized into three types: template/atlas-based, segmentation-based, and reconstruction-based...
December 14, 2016: NeuroImage
https://www.readbyqxmd.com/read/27986922/cocaine-promotes-coincidence-detection-and-lowers-induction-threshold-during-hebbian-associative-synaptic-potentiation-in-prefrontal-cortex
#19
Hongyu Ruan, Wei-Dong Yao
: Addictive drugs usurp neural plasticity mechanisms that normally serve reward-related learning and memory, primarily by evoking changes in glutamatergic synaptic strength in the mesocorticolimbic dopamine circuitry. Here we show that repeated cocaine exposure in vivo does not alter synaptic strength in the mouse prefrontal cortex during an early period of withdrawal, but instead modifies a Hebbian quantitative synaptic learning rule by broadening the temporal window and lowers the induction threshold for spike timing-dependent LTP (t-LTP)...
December 16, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27983992/single-injection-of-a-novel-nerve-growth-factor-coacervate-improves-structural-and-functional-regeneration-after-sciatic-nerve-injury-in-adult-rats
#20
Rui Li, Jiang Wu, Zhenkun Lin, Matthew R Nangle, Yi Li, Pingtao Cai, Dan Liu, Libin Ye, Zecong Xiao, Chaochao He, Jingjing Ye, Hongyu Zhang, Yingzheng Zhao, Jian Wang, Xiaokun Li, Yan He, Qingsong Ye, Jian Xiao
The prototypical neurotrophin, nerve growth factor (NGF), plays an important role in the development and maintenance of many neurons in both the central and peripheral nervous systems, and can promote functional recovery after peripheral nerve injury in adulthood. However, repair of peripheral nerve defects is hampered by the short half-life of NGF in vivo, and treatment with either NGF alone or NGF contained in synthetic nerve conduits is inferior to the use of nerve autografts, the current gold standard. We tested the reparative ability of a single local injection of a polyvalent coacervate containing polycation-poly(ethylene argininylaspartate diglyceride; PEAD), heparin, and NGF, in adult rats following sciatic nerve crush injury, using molecular, histological and behavioral approaches...
February 2017: Experimental Neurology
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