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https://www.readbyqxmd.com/read/28438599/newly-identified-invertebrate-type-lysozyme-splys-i-in-mud-crab-scylla-paramamosain-exhibiting-muramidase-deficient-antimicrobial-activity
#1
Jian Zhou, Shu Zhao, Wen-Hong Fang, Jun-Fang Zhou, Jing-Xiao Zhang, Hongyu Ma, Jiang-Feng Lan, Xin-Cang Li
Lysozymes are widely distributed immune effectors exerting muramidase activity against the peptidoglycan of the bacterial cell wall to trigger cell lysis. However, some invertebrate-type (i-type) lysozymes deficient of muramidase activity still exhibit antimicrobial activity. To date, the mechanism underlying the antimicrobial effect of muramidase-deficient i-type lysozymes remains unclear. Accordingly, this study characterized a novel i-type lysozyme, Splys-i, in the mud crab Scylla paramamosain. Splys-i shared the highest identity with the Litopenaeus vannamei i-type lysozyme (Lvlys-i2, 54% identity) at the amino acid level...
April 21, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28436652/observation-of-the-generation-of-onoo-in-mitochondria-under-various-stimuli-with-a-sensitive-fluorescence-probe
#2
Hongyu Li, Xiaohua Li, Xiaofeng Wu, Wen Shi, Huimin Ma
Peroxynitrite (ONOO-), an important reactive oxygen species (ROS), may be generated in the mitochondria under various physiological and pathological conditions. In this work, we designed and synthesized a mitochondria-targetable fluorescence probe RPTPP by using rhodamine as the fluorophore, phenylhydrazine as the recognition moiety, and triphenyl- phosphonium cation as the mitochondria-targeting moiety. Upon reaction of the probe with ONOO-, the oxidation of phenylhydrazine by ONOO- and the subsequent hydrolysis opens the non-fluorescent spirocyclic structure and thus triggers a fluorescence turn-on response, which provides a sensitive and selective method for the detection of ONOO-...
April 24, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28433898/performance-and-microbial-population-dynamics-during-stable-operation-and-reactivation-after-extended-idle-conditions-in-an-aerobic-granular-sequencing-batch-reactor
#3
Qiulai He, Wei Zhang, Shilu Zhang, Zhuocheng Zou, Hongyu Wang
The evolution of removal performance and bacterial population dynamics of an aerobic granular sequencing batch reactor were investigated during stable operation and reactivation after prolonged storage. The system was run for a period of 130days including the stable condition phase, storage period and the subsequent reactivation process. Excellent removal performance was obtained during the stable operation period, which was decayed by the extended idle conditions. The removal efficiencies for both carbon and nitrogen decayed while phosphorus removal remained unaffected...
April 1, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28429088/an-snp-panel-for-the-analysis-of-paternally-inherited-alleles-in-maternal-plasma-using-ion-torrent-pgm
#4
Donggui Yang, Hao Liang, Shaobin Lin, Qing Li, Xiaoyan Ma, Jun Gao, Hongyu Sun, Qingqing Chen, Jianzhu Wu, Xueling Ou
Researchers have sought to develop an effective protocol for paternity analysis using cell-free DNA (cfDNA) in maternal plasma. The use of massively parallel sequencing (MPS) technology for SNP testing is attractive because of its high-throughput capacity and resolution to single-base precision. In this study, we designed a customized SNP panel for cfDNA sequencing that includes 720 short amplicons (< 140 bp) targeting SNPs on the autosome and Y chromosome. The systemic performance was evaluated using the Ion Torrent PGM, indicating balanced coverage among most of the included loci, except for 78 poorly performing SNPs that were observed to have an inconsistent allele balance, lower coverage reads or high background signals...
April 20, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28425440/the-valosin-containing-protein-is-a-novel-mediator-of-mitochondrial-respiration-and-cell-survival-in-the-heart-in-vivo
#5
Paulo Lizano, Eman Rashed, Shaunrick Stoll, Ning Zhou, Hairuo Wen, Tristan T Hays, Gangjian Qin, Lai-Hua Xie, Christophe Depre, Hongyu Qiu
The valosin-containing protein (VCP) participates in signaling pathways essential for cell homeostasis in multiple tissues, however, its function in the heart in vivo remains unknown. Here we offer the first description of the expression, function and mechanism of action of VCP in the mammalian heart in vivo in both normal and stress conditions. By using a transgenic (TG) mouse with cardiac-specific overexpression (3.5-fold) of VCP, we demonstrate that VCP is a new and powerful mediator of cardiac protection against cell death in vivo, as evidenced by a 50% reduction of infarct size after ischemia/reperfusion versus wild type...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28418321/s100a10-identified-in-a-genome-wide-gene-%C3%A3-cannabis-dependence-interaction-analysis-of-risky-sexual-behaviours
#6
Renato Polimanti, Shashwath A Meda, Godfrey D Pearlson, Hongyu Zhao, Richard Sherva, Lindsay A Farrer, Henry R Kranzler, Joel Gelernter
BACKGROUND: We conducted a genome-wide gene × environment interaction analysis to identify genetic variants that interact with cannabis dependence (CaD) in influencing risky sexual behaviours (RSB). METHODS: Our sample included cannabis-exposed and sexually experienced African-American and European-American participants. A DSM-IV CaD diagnosis and RSB were evaluated using the Semi-Structured Assessment for Drug Dependence and Alcoholism. We analyzed RSBs as a score that takes into account experiences of unprotected sex and multiple sexual partners...
April 13, 2017: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/28415466/effect-of-lubricant-on-the-reliability-of-dental-implant-abutment-screw-joint-an-in-vitro-laboratory-and-three-dimension-finite-element-analysis
#7
Tingting Wu, Hongyi Fan, Ruiyang Ma, Hongyu Chen, Zhi Li, Haiyang Yu
Biomechanical factors play a key role in the success of dental implants. Fracture and loosening of abutment screws are major issues. This study investigated the effect of lubricants on the stability of dental implant-abutment connection. As lubricants, graphite and vaseline were coated on the abutment screw surface, respectively, and a blank without lubricant served as the control. The total friction coefficient (μtot), clamping force, fatigue behavior and detorque of the joint combined with dynamic cyclic loading were measured under different lubricating conditions...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28413051/protective-efficacy-of-a-novel-recombinant-marek-s-disease-virus-vector-vaccine-against-infectious-bursal-disease-in-chickens-with-or-without-maternal-antibodies
#8
Kai Li, Yongzhen Liu, Yanping Zhang, Li Gao, Changjun Liu, Hongyu Cui, Xiaole Qi, Yulong Gao, Li Zhong, Xiaomei Wang
Infectious bursal disease (IBD) causes significant clinical and economic losses to the poultry industry worldwide. Current vaccine programs using live attenuated and inactivated vaccines have numerous drawbacks. As an alternative solution to control IBD, a Marek's disease virus (MDV) vector vaccine (rMDV-VP2) expressing the VP2 gene of infectious bursal disease virus (IBDV) has been developed. In this study, the protective efficacy of rMDV-VP2 was evaluated in a dose-related experiment which showed that a single dose of 1000 PFU was sufficient to fully protect chickens against IBDV infection...
April 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28406444/identification-of-drought-responsive-micrornas-from-roots-and-leaves-of-alfalfa-by-high-throughput-sequencing
#9
Yue Li, Liqiang Wan, Shuyi Bi, Xiufu Wan, Zhenyi Li, Jing Cao, Zongyong Tong, Hongyu Xu, Feng He, Xianglin Li
Alfalfa, an important forage legume, is an ideal crop for sustainable agriculture and a potential crop for bioenergy resources. Drought, one of the most common environmental stresses, substantially affects plant growth, development, and productivity. MicroRNAs (miRNAs) are newly discovered gene expression regulators that have been linked to several plant stress responses. To elucidate the role of miRNAs in drought stress regulation of alfalfa, a high-throughput sequencing approach was used to analyze 12 small RNA libraries comprising of four samples, each with three biological replicates...
April 13, 2017: Genes
https://www.readbyqxmd.com/read/28402306/adsorptive-removal-of-rhodamine-b-from-aqueous-solution-by-nanoporous-polydivinylbenzene
#10
Hongyu Jia, Ningning Liu
Nanoporous polydivinylbenzene (PDVB) material has been successfully prepared via the copolymerization of divinylbenzene monomers. The nanoporous PDVB was characterized through N2 adsorption/desorption isotherms, Fourier transform infrared spectroscopy, scanning electron microscopy, and thermogravimetric analysis. The nanoporous PDVB as an adsorbent was applied for the removal of Rhodamine B (RhB). The adsorption behavior of PDVB for the removal of RhB showed that the isotherm data followed the Langmuir isotherm model and the kinetic adsorption obeyed the pseudo-second-order model...
April 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28402294/synthesis-and-characterization-of-a-novel-magnetic-biochar-from-sewage-sludge-and-its-effectiveness-in-the-removal-of-methyl-orange-from-aqueous-solution
#11
Jing Zhang, Mao Liu, Tao Yang, Kai Yang, Hongyu Wang
A novel magnetic biochar from sewage sludge (MSBC) using SrFe12O19 as magnetic substrate was successfully synthesized under high-temperature and oxygen-free conditions. Several techniques and methodologies (X-ray diffraction, Fourier transform infrared spectroscopy and vibrating sample magnetometer) were used to determine the surface functional groups and physicochemical properties of MSBC, which showed that the MSBC combined the features of both SrFe12O19 and sludge biochar (SBC). And then the adsorption behavior of methyl orange (MO) from aqueous solution onto the MSBC was investigated...
April 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28390526/attenuation-correction-of-pet-mr-imaging
#12
REVIEW
Yasheng Chen, Hongyu An
PET/MR is a promising multimodality imaging approach. Attenuation is by far the largest correction required for quantitative PET imaging. MR-based attenuation correction have been extensively pursued, especially for brain imaging, in the past several years. In this article, we review atlas and direct imaging MR-based PET attenuation correction methods. The technical principles behind these methods are detailed and the advantages and disadvantages of these methods are discussed.
May 2017: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/28389671/identification-of-a-six-lncrna-signature-associated-with-recurrence-of-ovarian-cancer
#13
Kai Yang, Yan Hou, Ang Li, Zhenzi Li, Wenjie Wang, Hongyu Xie, Zhiwei Rong, Ge Lou, Kang Li
Ovarian cancer (OvCa) is the leading cause of death among all gynecological malignancies, and recurrent OvCa is almost always incurable. In this study, we developed a signature based on long non-coding RNAs (lncRNAs) associated with OvCa recurrence to facilitate personalized OvCa therapy. lncRNA expression data were extracted from GSE9891 and GSE30161. LASSO (least absolute shrinkage and selection operator) penalized regression was used to identify an lncRNA-based signature using the GSE9891 training cohort...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28389631/metabolic-profiling-and-novel-plasma-biomarkers-for-predicting-survival-in-epithelial-ovarian-cancer
#14
Hongyu Xie, Yan Hou, Jinlong Cheng, Margarita S Openkova, Bairong Xia, Wenjie Wang, Ang Li, Kai Yang, Junnan Li, Huan Xu, Chunyan Yang, Libing Ma, Zhenzi Li, Xin Fan, Kang Li, Ge Lou
Epithelial ovarian cancer (EOC) is one of the most lethal gynecological malignancies around the world, and patients with ovarian cancer always have an extremely poor chance of survival. Therefore, it is meaningful to develop a highly efficient model that can predict the overall survival for EOC. In order to investigate whether metabolites could be used to predict the survival of EOC, we performed a metabolic analysis of 98 plasma samples with follow-up information, based on the ultra-performance liquid chromatography mass spectrometry (UPLC/MS) systems in both positive (ESI+) and negative (ESI-) modes...
March 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28386425/earliest-filter-feeding-pterosaur-from-the-jurassic-of-china-and-ecological-evolution-of-pterodactyloidea
#15
Chang-Fu Zhou, Ke-Qin Gao, Hongyu Yi, Jinzhuang Xue, Quanguo Li, Richard C Fox
Pterosaurs were a unique clade of flying reptiles that were contemporaries of dinosaurs in Mesozoic ecosystems. The Pterodactyloidea as the most species-diverse group of pterosaurs dominated the sky during Cretaceous time, but earlier phases of their evolution remain poorly known. Here, we describe a 160 Ma filter-feeding pterosaur from western Liaoning, China, representing the geologically oldest record of the Ctenochasmatidae, a group of exclusive filter feeders characterized by an elongated snout and numerous fine teeth...
February 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28386335/dl-3-n-butylphthalide-improves-functional-recovery-in-rats-with-spinal-cord-injury-by-inhibiting-endoplasmic-reticulum-stress-induced-apoptosis
#16
Zili He, Yulong Zhou, Yan Huang, Qingqing Wang, Binbin Zheng, Hongyu Zhang, Jiawei Li, Yanlong Liu, Fenzan Wu, Xie Zhang, Songlin Tong, Maofeng Wang, Zhouguang Wang, Huacheng He, Huazi Xu, Jian Xiao
Endoplasmic reticulum (ER) stress-induced apoptosis occurs in the spinal cord following traumatic spinal cord injury (SCI). Dl-3-n-butylphthalide (NBP) exerts an neuroprotective effects against both ischemic brain injury and neurodegenerative diseases; however, the relationship between ER stress-induced apoptosis and the therapeutic effect of NBP in SCI remains unclear. In this study, moderate spinal cord injuries were induced in Sprague-Dawley (SD) rats with a vascular clip. NBP was administered by oral (80 mg/kg/d) gavage 2 h before injury and then once daily for 28 d thereafter...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28382453/metabolic-adaptation-to-the-aqueous-leaf-extract-of-moringa-oleifera-lam-supplemented-diet-is-related-to-the-modulation-of-gut-microbiota-in-mice
#17
Xiaoyu Gao, Qiuhong Xie, Ling Liu, Ping Kong, Jun Sheng, Hongyu Xiang
The aqueous leaf extract of Moringa oleifera Lam. (LM-A) is reported to have many health beneficial bioactivities and no obvious toxicity, but have mild adverse effects. Little is known about the mechanism of these reported adverse effects. Notably, there has been no report about the influence of LM-A on intestinal microecology. In this study, animal experiments were performed to explore the relationships between metabolic adaptation to an LM-A-supplemented diet and gut microbiota changes. After 8-week feeding with normal chow diet, the body weight of mice entered a stable period, and one of the group received daily doses of 750-mg/kg body weight LM-A by gavage for 4 weeks (assigned as LM); the other group received the vehicle (assigned as NCD)...
April 5, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28375158/cct6a-suppresses-smad2-and-promotes-prometastatic-tgf-%C3%AE-signaling
#18
Zhe Ying, Han Tian, Yun Li, Rong Lian, Wei Li, Shanshan Wu, Hui-Zhong Zhang, Jueheng Wu, Lei Liu, Junwei Song, Hongyu Guan, Junchao Cai, Xun Zhu, Jun Li, Mengfeng Li
Paradoxically, during early tumor development in many cancer types, TGF-β acts as a tumor suppressor, whereas in the advanced stages of these cancers, increased TGF-β expression is linked to high metastasis and poor prognosis. These findings suggest that unidentified mechanisms may function to rewire TGF-β signaling toward its prometastatic role in cancer cells. Our current study using non-small-cell lung carcinoma (NSCLC) cell lines, animal models, and clinical specimens demonstrates that suppression of SMAD2, with SMAD3 function intact, switches TGF-β-induced transcriptional responses to a prometastatic state...
April 4, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28371641/recent-progress-in-the-identification-of-selective-butyrylcholinesterase-inhibitors-for-alzheimer-s-disease
#19
REVIEW
Qi Li, Hongyu Yang, Yao Chen, Haopeng Sun
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders with notable factor of dysfunction in cholinergic system. Low ACh level can be observed in the pathogenesis of AD. Several AChE inhibitors have already been used for clinical treatments. However, other than normal conditions, ACh is mostly hydrolyzed by BuChE in progressed AD. Account for an increased level of BuChE and decreased level of AChE in the late stage of AD, development of selective BuChE inhibitor is of vital importance...
March 27, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28359887/preparation-and-characterization-of-aminoethyl-hydroxypropyl-starch-modified-with-collagen-peptide
#20
Huigao Wen, Jin Hu, Hongyu Ge, Shengqiong Zou, Yao Xiao, Ya Li, Han Feng, Lihong Fan
The preparation of aminoethyl hydroxypropyl starch collagen peptide (AEHPS-COP) was via an enzyme-catalyzed reaction between amino groups in aminoethyl hydroxypropyl starch (AEHPS) and γ-carboxamide groups in collagen peptide (COP) by using microbial transglutaminase (MTGase) as biocatalyst. As an intermediate reactant, AEHPS was synthesized from hydroxypropyl starch (HPS) and 2-chloroethylamine hydrochloride (CEH). The chemical structures of HPS, AEHPS and AEHPS-COP were characterized by Fourier transform infrared spectroscopy (FT-IR) and (13)C nuclear magnetic resonance ((13)C NMR)...
March 27, 2017: International Journal of Biological Macromolecules
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