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https://www.readbyqxmd.com/read/29899328/increased-levels-of-the-long-noncoding-rna-hoxa-as3-promote-proliferation-of-a549-cells
#1
Hongyue Zhang, Ying Liu, Lixin Yan, Min Zhang, Xiufeng Yu, Wei Du, Siqi Wang, Qiaozhi Li, He Chen, Yafeng Zhang, Hanliang Sun, Zhidong Tang, Daling Zhu
Many long noncoding RNAs (lncRNAs) have been identified as powerful regulators of lung adenocarcinoma (LAD). However, the role of HOXA-AS3, a novel lncRNA, in LAD is largely unknown. In this study, we showed that HOXA-AS3 was significantly upregulated in LAD tissues and A549 cells. After knockdown of HOXA-AS3, cell proliferation, migration, and invasion were inhibited. Xenografts derived from A549 cells transfected with shRNA/HOXA-AS3 had significantly lower tumor weights and smaller tumor volumes. We also demonstrated that HOXA-AS3 increased HOXA6 mRNA stability by forming an RNA duplex...
June 13, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29896813/cardiovascular-benefits-of-reducing-personal-exposure-to-traffic-related-noise-and-particulate-air-pollution-a-randomized-crossover-study-in-the-beijing-subway-system
#2
Xuan Yang, Xu Jia, Wei Dong, Shaowei Wu, Mark R Miller, Dayu Hu, Hongyu Li, Lu Pan, Furong Deng, Xinbiao Guo
To assess the cardiovascular benefits of protecting against particulate air pollution and noise, we conducted a randomized crossover study with 40 young healthy college students from March to May 2017 in the underground subway, Beijing. Participants each received four treatments [no intervention phase (NIP), respirator intervention phase (RIP), headphone intervention phase (HIP), respirator plus headphone intervention phase (RHIP)] in a randomized order during four different study periods with two-week washout intervals...
June 13, 2018: Indoor Air
https://www.readbyqxmd.com/read/29896719/monitoring-tidal-flat-dynamics-affected-by-human-activities-along-an-eroded-coast-in-the-yellow-river-delta-china
#3
Yaoshen Fan, Shenliang Chen, Bo Zhao, Shoubing Yu, Hongyu Ji, Chao Jiang
The coast of the northern Yellow River Delta (YRD) has experienced significant erosion since 1976 due to avulsion and consequent lack of sediment supply. Moreover, massive reclamation activity, expansion of the oil industry, and sea-level rise have jointly contributed to the rapid change of tidal flats over recent decades. Therefore, accurate reporting of the coast spatial extent and stability status is urgently required. We presented a method using remotely sensed waterlines to map tidal flats and monitor their spatiotemporal dynamics...
June 12, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29895019/dual-delivery-of-bfgf-and-ngf-binding-coacervate-confers-neuroprotection-by-promoting-neuronal-proliferation
#4
Yanqing Wu, Zhouguang Wang, Pingtao Cai, Ting Jiang, Yiyang Li, Yuan Yuan, Rui Li, Sinan Khor, Yingfeng Lu, Jian Wang, Daqing Chen, Qiqiang Zeng, Ruisheng Zhong, Hongyu Zhang, Yuan Lin, Xiaokun Li, Jian Xiao
BACKGROUND/AIMS: Basic fibroblast growth factor (bFGF) and nerve growth factor (NGF) are essential for proper development, survival, growth, and maintenance of neurons in the central and peripheral nervous systems. However, because bFGF and NGF have short half-life and rapid diffusion rate, they have limited clinical efficacy. Thus, there is an urgent need to develop an effective delivery system to protect bFGF and NGF from proteolysis while maintaining their normal bioactivities. METHODS: To more efficiently deliver bFGF and NGF, we used a coacervate (synthesized with heparin and a biodegradable polycation at mass ratio of 500: 100)...
June 12, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29890415/montelukast-inhibits-inflammatory-response-in-rheumatoid-arthritis-fibroblast-like-synoviocytes
#5
Hongyu Dong, Feng Liu, Fengyun Ma, Lianna Xu, Linna Pang, Xuyan Li, Bo Liu, Liang Wang
Montelukast, a potent selective antagonist of cysteinyl leukotriene (cysLT) receptors, has displayed its important anti-oxidative and anti-inflammatory effects in various tissues and organs. Rheumatoid arthritis (RA) is an immune disease defined by hyperplastic synovitis and joint destruction. Fibroblast-like synoviocytes in RA (RA-FLSs) are the main cell component of the hyperplastic synovium. Whether montelukast can protect against the inflammatory milieu of RA remains unclear. Here, it is shown that cysLT1R is present in FLSs and unregulated in RA-FLSs...
June 8, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29885586/a-novel-bioscaffold-with-naturally-occurring-extracellular-matrix-promotes-hepatocyte-survival-and-vessel-patency-in-mouse-models-of-heterologous-transplantation
#6
Wei Yang, Quanyu Chen, Renpei Xia, Yujun Zhang, Ling Shuai, Jiejuan Lai, Xiaolin You, Yan Jiang, Ping Bie, Leida Zhang, Hongyu Zhang, Lianhua Bai
BACKGROUND: Naïve decellularized liver scaffold (nDLS)-based tissue engineering has been impaired by the lack of a suitable extracellular matrix (ECM) to provide "active micro-environmental" support. AIM: The present study aimed to examine whether a novel, regenerative DLS (rDLS) with an active ECM improves primary hepatocyte survival and prevents thrombosis. METHODS: rDLS was obtained from a 30-55% partial hepatectomy that was maintained in vivo for 3-5 days and then perfused with detergent in vitro...
May 28, 2018: Biomaterials
https://www.readbyqxmd.com/read/29882471/microrna-222-promotes-invasion-and-metastasis-of-papillary-thyroid-cancer-through-targeting-protein-phosphatase-2-regulatory-subunit-b-alpha-expression
#7
Yanrui Huang, Shuang Yu, Siting Cao, Yali Yin, Shubin Hong, Hongyu Guan, Yanbing Li, Haipeng Xiao
BACKGROUND: Increasing evidence indicates that microRNA dysfunction is involved in the pathogenesis and progression of cancer. MicroRNA-222 (miR-222) is upregulated in papillary thyroid carcinoma (PTC); however, the role of miR-222 in invasion and metastasis of PTC remains unknown. In this study, we investigated the function of miR-222 and its underlying mechanism in the progression of PTC. METHODS: The expression of miR-222 was detected by qRT-PCR and its correlation with various clinical characteristics was analyzed...
June 8, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29881543/whole-genome-sequence-revealed-the-fine-transmission-map-of-carbapenem-resistant-klebsiella-pneumonia-isolates-within-a-nosocomial-outbreak
#8
Wenjun Sui, Haijian Zhou, Pengcheng Du, Lijun Wang, Tian Qin, Mei Wang, Hongyu Ren, Yanfei Huang, Jing Hou, Chen Chen, Xinxin Lu
Background: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a major cause of nosocomial infections worldwide. The transmission route of CRKP isolates within an outbreak is rarely described. This study aimed to reveal the molecular characteristics and transmission route of CRKP isolates within an outbreak of nosocomial infection. Methods: Collecting case information, active screening and targeted environmental monitoring were carried out. The antibiotic susceptibility, drug-resistant genes, molecular subtype and whole genome sequence of CRKP strains were analyzed...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29875475/translational-studies-support-a-role-for-serotonin-2b-receptor-htr2b-gene-in-aggression-related-cannabis-response
#9
Janitza L Montalvo-Ortiz, Hang Zhou, Ivana D'Andrea, Luc Maroteaux, Adriana Lori, Alicia Smith, Kerry J Ressler, Yaira Z Nuñez, Lindsay A Farrer, Hongyu Zhao, Henry R Kranzler, Joel Gelernter
Cannabis use is increasing in the United States, as are its adverse effects. We investigated the genetics of an adverse consequence of cannabis use: cannabis-related aggression (CRA) using a genome-wide association study (GWAS) design. Our GWAS sample included 3269 African Americans (AAs) and 2546 European Americans (EAs). An additional 89 AA subjects from the Grady Trauma Project (GTP) were also examined using a proxy-phenotype replication approach. We identified genome-wide significant risk loci contributing to CRA in AAs at the serotonin receptor 2B receptor gene (HTR2B), and the lead SNP, HTR2B*rs17440378, showed nominal association to aggression in the GTP cohort of cannabis-exposed subjects...
June 6, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29873378/platinum-nanoparticles-an-avenue-for-enhancing-the-release-of-nitric-oxide-from-s-nitroso-n-acetylpenicillamine-and-s-nitrosoglutathione
#10
Gao-Juan Cao, Christine M Fisher, Xiumei Jiang, Yu Chong, Hui Zhang, Hongyu Guo, Qian Zhang, Jiwen Zheng, Ann M Knolhoff, Timothy R Croley, Jun-Jie Yin
Nitric oxide (NO) is an endogenous bioregulator with established roles in diverse fields. The difficulty in the modulation of NO release is still a significant obstacle to achieving successful clinical applications. We report herein our initial work using electron spin resonance (ESR) spectroscopy to detect NO generated from S-nitroso-N-acetylpenicillamine (SNAP) and S-nitrosoglutathione (GSNO) donors catalyzed by platinum nanoparticles (Pt NPs, 3 nm) under physiological conditions. With ESR spectroscopy coupled with spin trapping and spin labeling techniques, we identified that Pt NPs can significantly promote the generation of NO from SNAP and GSNO under physiological conditions...
June 6, 2018: Nanoscale
https://www.readbyqxmd.com/read/29872624/biomimetic-albumin-modified-gold-nanorods-for-photothermo-chemotherapy-and-macrophage-polarization-modulation
#11
Dongdong Li, Meng Zhang, Fan Xu, Yingzhi Chen, Binfan Chen, Ya Chang, Huihai Zhong, Hongyue Jin, Yongzhuo Huang
Nanotechnology-based photothermal therapy has attracted great attention in the past decade. Nevertheless, photothermal therapy has some inherent drawbacks, such as the uneven heat production and limited laser penetration, often leading to insufficient treatment outcomes. Here, we developed a combination strategy to improve cancer therapy. The biomimetic albumin-modified gold nanorods (AuNRs) were prepared with incorporation of paclitaxel (PTX). This therapeutic system was characterized by several features. First, the albumin modification enhanced the biocompatibility and colloidal stability...
January 2018: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/29844835/circulating-and-tumor-infiltrating-myeloid-derived-suppressor-cells-in-cervical-carcinoma-patients
#12
Liangliang Wu, Hongyu Liu, Hongchuan Guo, Qiong Wu, Songyan Yu, Yuanyuan Qin, Gang Wang, Qiyan Wu, Rong Zhang, Lingxiong Wang, Lijun Zhang, Chunxi Liu, Shunchang Jiao, Tianyi Liu
Myeloid-derived suppressor cells (MDSCs) serve an immunosuppressive role in human tumors. Human Lin-/low human leukocyte antigen-antigen D related (HLA-DR- ) cluster of differentiation (CD)-11b+ CD33+ MDSCs are closely linked with tumor staging, progression, clinical therapeutic efficacy and prognosis for various types of tumors. The present study employed multiparametric flow cytometry to measure the proportion of Lin-/low HLA-DR- CD11b+ CD33+ MDSCs in the peripheral blood of 105 cervical cancer patients and 50 healthy subjects...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29844337/quality-control-of-the-traditional-chinese-medicine-ruyi-jinhuang-powder-based-on-high-throughput-sequencing-and-real-time-pcr
#13
Qiang Li, Ying Sun, Huijun Guo, Feng Sang, Hongyu Ma, Hai Peng, Na Zheng, Liran Xu
Traditional Chinese medicine (TCM) has been practiced for thousands of years, although concerns about the efficacy, legality, and safety of TCM continue to be raised. Chromatographic studies have detected the presence of heavy metals and plant toxins within some TCM preparations. However, chromatography is not able to identify all of the compounds of TCM, particularly those items that are not clearly labeled on the packaging. The present study aimed to establish a supplemental method that better assesses the ingredient components of TCM preparations...
May 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29802564/enhancing-the-production-of-d-mannitol-by-an-artificial-mutant-of-penicillium-sp-t2-m10
#14
Rongting Duan, Hongtao Li, Hongyu Li, Linhuan Tang, Hao Zhou, Xueqiong Yang, Yabin Yang, Zhongtao Ding
D-Mannitol belongs to a linear polyol with six-carbon and has indispensable usage in medicine and industry. In order to obtain more efficient D-mannitol producer, this study has screened out a stable mutant Penicillium sp. T2-M10 that was isolated from the initial D-mannitol-produced strain Penicillium sp.T2-8 via UV irradiation as well as nitrosoguanidine (NTG) induction. The mutant had a considerable enhancement in yield of D-mannitol based on optimizing fermentation. The production condition was optimized as the PDB medium with 24 g/L glucose for 9 days...
May 26, 2018: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29801842/mechanism-and-structure-studies-of-cinnamaldehyde-cyclodextrins-inclusions-by-computer-simulation-and-nmr-technology
#15
Qiaomei Sun, Peixiao Tang, Ludan Zhao, Hongyu Pu, Yuanming Zhai, Hui Li
This work aims to explore the inclusion mechanism and structure of cinnamaldehyde (CNMA) and cyclodextrins (CDs), and to provide some theoretical information for the application of CNMA and its inclusion. In this study, we prepared three kinds of inclusion and investigated the mechanism and structure by theory and experiment. Molecular docking and dynamical simulations presented a stable 1:1 inclusion complex and the visual structure model. The structural features indicated that the benzene ring of CNMA was enclosed in the hydrophobic cavity of CDs, which were consistent with the results of 1 H NMR, 2D-ROESY, Fourier transform infrared spectroscopy...
August 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29800903/identification-of-10-kd-peptides-in-the-water-extraction-of-venenum-bufonis-from-bufo-gargarizans-using-nano-lc-ms-ms-and-de-novo-sequencing
#16
Yiguo Huo, Ruoxian Xv, Hongyue Ma, Jing Zhou, Xinping Xi, Qinan Wu, Jinao Duan, Mei Zhou, Tianbao Chen
Skins of anurans (frogs and toads) are rich sources of bioactive peptides. However, the peptides secreted by the skin glands of Bufo gargarizans, the most common toad in China, remained unexplored to date. Here, a strategy combines LC-MS/MS, RNA sequencing and bioinformation analysis was applied to unravel the peptides in the Bufo gargarizans secretions. Data-dependent LC-MS/MS acquisitions of intact peptides followed by automated chromatographic alignment, De novo analysis, database and homology searches with manual validations showed that the venom is composed by 939 features, with masses ranging from 0...
May 19, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29798879/cobalt-catalyzed-asymmetric-hydrogenation-of-enamides-enabled-by-single-electron-reduction
#17
Max R Friedfeld, Hongyu Zhong, Rebecca T Ruck, Michael Shevlin, Paul J Chirik
Identifying catalyst activation modes that exploit one-electron chemistry and overcome associated deactivation pathways will be transformative for developing first-row transition metal catalysts with performance equal or, ideally, superior to precious metals. Here we describe a zinc-activation method compatible with high-throughput reaction discovery that identified scores of cobalt-phosphine combinations for the asymmetric hydrogenation of functionalized alkenes. An optimized catalyst prepared from ( R , R )-Ph-BPE {Ph-BPE, 1,2-bis[(2 R ,5 R )-2,5-diphenylphospholano]ethane} and cobalt chloride [CoCl2 ·6H2 O] exhibited high activity and enantioselectivity in protic media and enabled the asymmetric synthesis of the epilepsy medication levetiracetam at 200-gram scale with 0...
May 25, 2018: Science
https://www.readbyqxmd.com/read/29796000/in-vessel-co-composting-of-food-waste-employing-enriched-bacterial-consortium
#18
Mukesh Kumar Awasthi, Quan Wang, Meijing Wang, Hongyu Chen, Xiuna Ren, Junchao Zhao, Zengqiang Zhang
The aim of the present study is to develop a good initial composting mix using a bacterial consortium and 2% lime for effective co-composting of food waste in a 60-litre in-vessel composter. In the experiment that lasted for 42 days, the food waste was first mixed with sawdust and 2% lime (by dry mass), then one of the reactors was inoculated with an enriched bacterial consortium, while the other served as control. The results show that inoculation of the enriched natural bacterial consortium effectively overcame the oil-laden co-composting mass in the composter and increased the rate of mineralization...
March 2018: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/29795754/phenotypic-screening-to-discover-novel-chemical-series-as-efficient-antihemorrhagic-agents
#19
Irene de Miguel, Josune Orbe, Juan A Sánchez-Arias, José A Rodríguez, Agustina Salicio, Obdulia Rabal, Miriam Belzunce, Elena Sáez, Musheng Xu, Wei Wu, Haizhong Tan, Hongyu Ma, José A Páramo, Julen Oyarzabal
In an effort to find novel chemical series as antifibrinolytic agents, we explore α-phenylsulfonyl-α-spiropiperidines bearing different zinc-binding groups (ZBGs) to target those metalloproteinases involved in the fibrinolytic process: MMP3 and MMP10. Surprisingly, all these new chemical series were inactive against these metalloproteinases; however, several new molecules retained the antifibrinolytic activity in a phenotypic functional assay using thromboelastometry and human whole blood. Further optimization led to compound 38 as a potent antifibrinolytic agent in vivo, three times more efficacious than the current standard-of-care (tranexamic acid, TXA) at 300 times lower dose...
May 10, 2018: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29795387/ogg1-initiated-base-excision-repair-exacerbates-oxidative-stress-induced-parthanatos
#20
Ruoxi Wang, Chunshuang Li, Ping Qiao, Yaoyao Xue, Xu Zheng, Hongyu Chen, Xianlu Zeng, Wenguang Liu, Istvan Boldogh, Xueqing Ba
Oxidative stress-induced DNA damage has been well acknowledged as a major cause leading to cell death, which is etiologically linked to ischemic injury and degenerative alterations. The most common oxidation product of DNA is base lesion 8-oxo-7,8-dihydroguanine (8-oxoG), which is repaired by 8-oxoG glycosylase1 (OGG1)-initiated baseexcision repair (BER) pathway (OGG1-BER); however, the role of OGG1-BER in oxidative stress-induced cell death is poorly investigated. DNA strand breaks and apurinic/apyrimidinic (AP) sites are effective substrates to activate DNA damage sensor poly(ADP-ribose) polymerase 1 (PARP1)...
May 24, 2018: Cell Death & Disease
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