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Hongyu an

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https://www.readbyqxmd.com/read/29672956/metal-organic-framework-derived-carbon-nanostructure-augmented-sonodynamic-cancer-therapy
#1
Xueting Pan, Lixin Bai, Hui Wang, Qingyuan Wu, Hongyu Wang, Shuang Liu, Bolong Xu, Xinghua Shi, Huiyu Liu
Sonodynamic therapy (SDT) can overcome the critical issue of depth-penetration barrier of photo-triggered therapeutic modalities. However, the discovery of sonosensitizers with high sonosensitization efficacy and good stability is still a significant challenge. In this study, the great potential of metal-organic-framework (MOF)-derived carbon nanostructure (PMCS) to act as an excellent sonosensitizer is identified. Excitingly, the superior sonosensitization effect of PMCS is believed to be closely linked to the porphyrin-like macrocycle in MOF-derived nanostructure in comparison to amorphous carbon nanospheres, due to their large highest occupied molecular orbital (HOMO)-lowest unoccupied molecular orbital (LUMO) gap for high reactive oxygen species (ROS) production...
April 19, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29670291/transient-adhesion-in-a-non-fully-detached-contact
#2
Zheyu Liu, Hongyu Lu, Yelong Zheng, Dashuai Tao, Yonggang Meng, Yu Tian
Continuous approaching and detaching displacement usually occurs in an adhesion test. Here, we found a transient adhesion force at the end of a non-fully detached contact. This force occurred when the nominal detaching displacement was less than the traditional quasi-static theory predicted zero force point. The transient adhesion force was ascribed to interfacial adhesion hysteresis, which was caused by the cracking process of the contact and the deformation competition between the sphere and supporting spring...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29649151/dna-methylation-and-histone-modification-in-hypertension
#3
REVIEW
Shaunrick Stoll, Charles Wang, Hongyu Qiu
Systemic hypertension, which eventually results in heart failure, renal failure or stroke, is a common chronic human disorder that particularly affects elders. Although many signaling pathways involved in the development of hypertension have been reported over the past decades, which has led to the implementation of a wide variety of anti-hypertensive therapies, one half of all hypertensive patients still do not have their blood pressure controlled. The frontier in understanding the molecular mechanisms underlying hypertension has now advanced to the level of epigenomics...
April 12, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29645023/fepo-4-as-an-anode-material-to-obtain-high-performance-sodium-based-dual-ion-batteries
#4
Chao Li, Xiaohong Wang, Jiayu Li, Hongyu Wang
Herein, the FePO4 material was for the first time proposed to serve as an anode electrode, as an intercalation sodium host, to obtain novel sodium-based dual-ion batteries. And the full cell can present a highly reversible capacity of 120 mA h g-1 in the range of 2-4.2 V and exhibits an excellent initial coulombic efficiency of 99.5%.
April 12, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29643824/the-topological-properties-of-stimuli-influence-fear-generalization-and-extinction-in-humans
#5
Liang Xu, Hongyu Su, Xiaoyuan Xie, Pei Yan, Junjiao Li, Xifu Zheng
Fear generalization is an etiologically significant indicator of anxiety disorders, and understanding how to inhibit it is important in their treatment. Prior studies have found that reducing fear generalization using a generalization stimulus (GS) is ineffective in removing a conditioned fear that incorporates local features, and that topological properties appear to play a comparatively more significant role in the processes of perception and categorization. Our study utilized a conditioned-fear generalization design to examine whether the topological properties of stimuli influence the generalization and return of fear...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29628370/the-er-contact-proteins-vapa-b-interact-with-multiple-autophagy-proteins-to-modulate-autophagosome-biogenesis
#6
Yan G Zhao, Nan Liu, Guangyan Miao, Yong Chen, Hongyu Zhao, Hong Zhang
The endoplasmic reticulum (ER) is the site of biogenesis of the isolation membrane (IM, autophagosome precursor) and forms extensive contacts with IMs during their expansion into double-membrane autophagosomes. Little is known about the molecular mechanism underlying the formation and/or maintenance of the ER/IM contact. The integral ER proteins VAPA and VAPB (VAPs) participate in establishing ER contacts with multiple membranes by interacting with different tethers. Here, we demonstrate that VAPs also modulate ER/IM contact formation...
March 31, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29627306/paraquat-and-mptp-induce-alteration-in-the-expression-profile-of-long-noncoding-rnas-in-the-substantia-nigra-of-mice-role-of-the-transcription-factor-nrf2
#7
Lijin Wang, Hongyu Yang, Qingqing Wang, Qiaohui Zhang, Zhangjing Wang, Qunwei Zhang, Siying Wu, Huangyuan Li
Parkinson's disease (PD) is a common age-related degenerative disease of the central nervous system caused mainly by hereditary, pesticides, metals, and polychlorinated biphenyls. Paraquat (PQ), a widely used herbicide, causes PD. Long noncoding RNAs (lncRNAs) are nonprotein-coding transcripts, expressed in the brain and play irreplaceable roles in neurodegenerative diseases. NF-E2-related factor-2 (Nrf2) is an important genetic transcription regulator in oxidative stress. We aimed to discover novel PQ or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-Nrf2-related lncRNAs and explore their association with PD...
April 5, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29614485/mir-99a-enhances-the-radiation-sensitivity-of-non-small-cell-lung-cancer-by-targeting-mtor
#8
Hang Yin, Jianqun Ma, Lin Chen, Shiqi Piao, Yu Zhang, Siliang Zhang, Hongyu Ma, Yang Li, Yuanyuan Qu, Xiaoyuan Wang, Qingyong Xu
BACKGROUND/AIMS: Radiation therapy is an important and effective modality for the treatment of non-small cell lung cancer (NSCLC). MicroRNAs (miRNAs) are crucial post-transcriptional regulators that are involved in numerous important biologic processes. However, their potential involvement in radiation sensitivity remains unknown. MATERIALS: We performed integrated analysis of miRNA expression in NSCLC using The Cancer Genome Atlas datasets. miR-99a was found to be significantly upregulated in cancer tissue and regulated cell survival...
March 26, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29610998/a-modified-method-for-genomic-dna-extraction-from-the-fish-intestinal-microflora
#9
Zhuoran Han, Jingfeng Sun, Aijun Lv, YeongYik Sung, Xueliang Sun, Hongyue Shi, Xiucai Hu, Anli Wang, Kezhi Xing
A modified genomic DNA extraction method named the combination of lysozyme and ultrasonic lysis (CLU) method was used to analyze the fish intestinal microflora. In this method, the physical disruption and chemical lysis steps were combined, and some parameters in the key steps were adjusted. In addition, the results obtained by this method were compared with the results obtained by the Zirmil-beating cell disruption method and the QIAamp Fast DNA Stool Mini Kit. The OD260 /OD280 ratio and concentration of the DNA extracted using the CLU method were 2...
April 2, 2018: AMB Express
https://www.readbyqxmd.com/read/29610209/an-spx-rli1-module-regulates-leaf-inclination-in-response-to-phosphate-availability-in-rice
#10
Wenyuan Ruan, Meina Guo, Lei Xu, Xueqing Wang, Hongyu Zhao, Junmin Wang, Keke Yi
Leaf erectness is one of the key traits of plant architecture; in grains, plants with upright leaves can be planted close together, thus benefiting yield/unit area. Many factors, such as hormones, affect leaf inclination; however, how nutrition status, in particular phosphate (Pi) availability, affects leaf inclination remains largely unexplained. Here, we show that in rice (Oryza sativa), Pi-deficiency stress inhibits lamina joint cell elongation, thus restricting lamina joint size and inducing leaf erectness in rice...
April 2, 2018: Plant Cell
https://www.readbyqxmd.com/read/29609406/ultraviolet-light-induced-terahertz-modulation-of-an-indium-oxide-film
#11
Hongyu Ji, Bo Zhang, Wei Wang, Longfeng Lv, Jingling Shen
Active ultraviolet light-induced terahertz modulation of an indium oxide film is investigated. A large absorption modulation of ~66% is achieved upon illumination with a low intensity UV laser (11 mW/cm2 ). The interaction between indium oxide and a flexible metamaterial structure is investigated owing to the large UV-induced enhancement of photo carriers observed in an indium oxide film. We are able to realize absorption peak shifts of 37 GHz by changing the UV excitation light intensity. We also propose a multi-frequency switch by building a circular metallic split ring resonator whose gaps are filled with silicon, germanium, and indium oxide...
March 19, 2018: Optics Express
https://www.readbyqxmd.com/read/29609354/explanation-of-the-distorted-spectrum-in-a-spectral-hole-burning-rf-spectrum-analyzer-using-bloch-equations
#12
Guofang Fan, Yuan Li, Chunguang Hu, Jiasi Wei, Hongyu Li
A readout using a frequency-chirped laser is investigated in a spectrum analyzer with spectral-hole-burning (SHB). An analysis based on the Bloch equations is presented for the spectral distortion due to a fast readout, and a recovery algorithm is developed for the distortion. The experiment of a SHB spectrum analyzer is executed to demonstrate the optical spectral distortion due to fast readout. The experimental spectral distortion is recovered by the recovery algorithm developed from the Bloch equations.
March 19, 2018: Optics Express
https://www.readbyqxmd.com/read/29609091/heparin-poloxamer-thermosensitive-hydrogel-loaded-with-bfgf-and-ngf-enhances-peripheral-nerve-regeneration-in-diabetic-rats
#13
Rui Li, Yiyang Li, Yanqing Wu, Yingzheng Zhao, Huanwen Chen, Yuan Yuan, Ke Xu, Hongyu Zhang, Yingfeng Lu, Jian Wang, Xiaokun Li, Xiaofeng Jia, Jian Xiao
Peripheral nerve injury (PNI) is a major burden to society with limited therapeutic options, and novel biomaterials have great potential for shifting the current paradigm of treatment. With a rising prevalence of chronic illnesses such as diabetes mellitus (DM), treatment of PNI is further complicated, and only few studies have proposed therapies suitable for peripheral nerve regeneration in DM. To provide a supportive environment to restore structure and/or function of nerves in DM, we developed a novel thermo-sensitive heparin-poloxamer (HP) hydrogel co-delivered with basic fibroblast growth factor (bFGF) and nerve growth factor (NGF) in diabetic rats with sciatic nerve crush injury...
March 26, 2018: Biomaterials
https://www.readbyqxmd.com/read/29604117/recognition-of-protein-allosteric-states-and-residues-machine-learning-approaches
#14
Hongyu Zhou, Zheng Dong, Peng Tao
Allostery is a process by which proteins transmit the effect of perturbation at one site to a distal functional site upon certain perturbation. As an intrinsically global effect of protein dynamics, it is difficult to associate protein allostery with individual residues, hindering effective selection of key residues for mutagenesis studies. The machine learning models including decision tree (DT) and artificial neural network (ANN) models were applied to develop classification model for a cell signaling allosteric protein with two states showing extremely similar tertiary structures in both crystallographic structures and molecular dynamics simulations...
March 31, 2018: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29603864/vascular-smooth-muscle-cells-direct-extracellular-dysregulation-in-aortic-stiffening-of-hypertensive-rats
#15
Tristan T Hays, Ben Ma, Ning Zhou, Shaunrick Stoll, William J Pearce, Hongyu Qiu
Aortic stiffening is an independent risk factor that underlies cardiovascular morbidity in the elderly. We have previously shown that intrinsic mechanical properties of vascular smooth muscle cells (VSMCs) play a key role in aortic stiffening in both aging and hypertension. Here, we test the hypothesis that VSMCs also contribute to aortic stiffening through their extracellular effects. Aortic stiffening was confirmed in spontaneously hypertensive rats (SHRs) vs. Wistar-Kyoto (WKY) rats in vivo by echocardiography and ex vivo by isometric force measurements in isolated de-endothelized aortic vessel segments...
March 30, 2018: Aging Cell
https://www.readbyqxmd.com/read/29601606/chronic-noise-exposure-exacerbates-insulin-resistance-and-promotes-the-manifestations-of-the-type-2-diabetes-in-a-high-fat-diet-mouse-model
#16
Lijie Liu, Yi Huang, Cong Fang, Hongyu Zhang, Jing Yang, Chuanying Xuan, Fanfan Wang, Haiying Lu, Shuangfeng Cao, Yongfang Wang, Shengwei Li, Jun Sha, Mingming Zha, Min Guo, Jian Wang
Epidemiological studies have revealed that noise exposure was associated with an increased risk of type 2 diabetes mellitus (T2DM). However, the exact nature of that association remains to be elucidated. The present study is designed to examine the effects of chronic noise exposure on the development of T2DM in combination with a high-fat-diet (HFD) in mice. Here we show that chronic noise exposure at 85 dB SPL (4 h /day, below the safety limit for occupational noise exposure) exaggerated multiple metabolic abnormalities induced by HFD in C57BL/6J male mice, including worsened glucose intolerance, insulin resistance, fasting hyperglycemia and dyslipidemia...
2018: PloS One
https://www.readbyqxmd.com/read/29575654/spermidine-promotes-nucleus-pulposus-autophagy-as-a-protective-mechanism-against-apoptosis-and-ameliorates-disc-degeneration
#17
Zengming Zheng, Zhou-Guang Wang, Yu Chen, Jian Chen, Sinan Khor, Jiawei Li, Zili He, Qingqing Wang, Hongyu Zhang, Ke Xu, Gong Fanghua, Jian Xiao, Xiangyang Wang
Spermidine has therapeutic effects in many diseases including as heart diastolic function, myopathic defects and neurodegenerative disorders via autophagy activation. Autophagy has been found to mitigate cell apoptosis in intervertebral disc degeneration (IDD). Accordingly, we theorize that spermidine may have beneficial effects on IDD via autophagy stimulation. In this study, spermidine's effect on IDD was evaluated in tert-butyl hydroperoxide (TBHP)-treated nucleus pulposus cells of SD rats in vitro as well as in a puncture-induced rat IDD model...
March 25, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29574509/linkage-disequilibrium-and-functional-analysis-of-pre1-insertion-together-with-snps-in-the-promoter-region-of-igfbp7-gene-in-different-pig-breeds
#18
Qingyan Wu, Hao Yu, Wenzhen Wei, Yunyun Cheng, Shan Huang, Hongyu Shi, Songcai Liu, Jichao Xia, Hongyao Jia, Linlin Hao
Polymorphisms in regions upstream of transcription initiation site may modify the transcriptional activity of target genes by changing promoter activity. This study aims to determine whether or not polymorphisms at porcine IGFBP7 promoter region affect gene expression. In this study, eight SNPs and one PRE1 insertion in this region were first confirmed. The PRE1 insertion was widespread in 20 Chinese indigenous breeds, but was not observed in three commercial breeds. A perfect linkage disequilibrium, consisting of six of those SNPs and a PRE1, was observed with two haplotypes (h1 and h2) in five pig breeds...
March 25, 2018: Journal of Applied Genetics
https://www.readbyqxmd.com/read/29572073/ros-independent-toxicity-of-fe-3-o-4-nanoparticles-to-yeast-cells-involvement-of-mitochondrial-dysfunction
#19
Qi Peng, Da Huo, Hongyue Li, Bing Zhang, Yang Li, Anping Liang, Hui Wang, Qilin Yu, Mingchun Li
Fe3 O4 nanoparticles, one kind of magnetic nanomaterials (NMs), are widely used in drug delivery, biological imaging, sensors, catalysts and pollution management. However, its toxicity to biological systems and related toxicity mechanisms remain to be explored. In this study, we investigate the effect of as-synthesized Fe3 O4 nanoparticles on growth of Saccharomyces cerevisiae, an important model fungus. Growth inhibition assays showed that Fe3 O4 nanoparticles remarkably inhibited yeast growth. Interestingly, this inhibitory effect was not attributed to the well-known plasma membrane damage, cell wall damage and ROS accumulation...
March 20, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29567101/nahs-restores-mitochondrial-function-and-inhibits-autophagy-by-activating-the-pi3k-akt-mtor-signalling-pathway-to-improve-functional-recovery-after-traumatic-brain-injury
#20
Kebin Xu, Fangfang Wu, Ke Xu, Zhengmao Li, Xiaojie Wei, Qi Lu, Ting Jiang, Fenzan Wu, Xinlong Xu, Jian Xiao, Daqing Chen, Hongyu Zhang
Traumatic brain injury (TBI) is one of the most serious public health problems in the world. TBI causes neurological deficits by triggering secondary injuries. Hydrogen sulfide (H2 S), a gaseous mediator, has been reported to exert neuroprotective effects in central nervous system diseases, such as TBI. However, the molecular mechanisms involved in this effect are still unclear. The present study was designed to explore the ability of NaHS, a H2 S donor, to provide neuroprotection in a mouse model of TBI and to discover the associated molecular mechanisms of these protective effects...
March 19, 2018: Chemico-biological Interactions
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