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https://www.readbyqxmd.com/read/29463625/growth-differentiation-factor-11-promotes-abnormal-proliferation-and-angiogenesis-of-pulmonary-artery-endothelial-cells
#1
Xiufeng Yu, Xinxin Chen, Xiao Dong Zheng, Junting Zhang, Xijuan Zhao, Ying Liu, Hongyue Zhang, Lixin Zhang, Hao Yu, Min Zhang, Cui Ma, Xuewei Hao, Daling Zhu
Disordered proliferation and angiogenesis of pulmonary artery endothelial cells is an important stage in the development of pulmonary arterial hypertension. Recent studies revealed that GDF11 (growth differentiation factor 11) induces endothelial cells proliferation and migration; however, whether GDF11 is directly involved in the pathogenesis of pulmonary arterial hypertension remains unknown. Here, we found that GDF11 was significantly upregulated and activated in 2 experimental pulmonary arterial hypertension models and cultured pulmonary artery endothelial cells...
February 20, 2018: Hypertension
https://www.readbyqxmd.com/read/29462747/involvement-of-a-newly-identified-atypical-type-ii-crustin-spcrus5-in-the-antibacterial-immunity-of-mud-crab-scylla-paramamosain
#2
Yue Wang, Chao Zhang, Hui Wang, Hongyu Ma, Yan-Qing Huang, Jian-Xue Lu, Xin-Cang Li, Xiao-Wen Zhang
Crustins, the main AMP family in Crustacea, are generated as isoforms in many species and implicated in innate immune responses, but their detailed molecular mechanisms on susceptible bacteria remain largely unclear. Type II and type I crustins are distinguished by glycine-rich region (GRR), which is a major marker motif, and some type II crustins exhibit stronger antibacterial activities than their GRR deletion mutants. In the present study, a novel crustin, namely, SpCrus5, was functionally characterized from a commercially valuable crab Scylla paramamosain...
February 17, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29456261/insights-into-activation-of-cobalt-pre-catalysts-for-c-sp-2-h-functionalization
#3
Jennifer V Obligacion, Hongyu Zhong, Paul J Chirik
The activation of readily prepared, air-stable cobalt (II) bis(carboxylate) pre-catalysts for the functionalization of C( sp 2 )-H bonds has been systematically studied. With the pyridine bis(phosphine) chelate,iPr PNP, treatment of 1-(O2 Ct Bu)2 with either B2 Pin2 or HBPin generated cobalt boryl products. With the former, reduction to (iPr PNP)CoI BPin was observed while with the latter, oxidation to the cobalt(III) dihydride boryl, trans -(iPr PNP)Co(H)2 BPin occurred. The catalytically inactive cobalt complex, Co[PinB(O2 Ct Bu)2 ]2, accompanied formation of the cobalt-boryl products in both cases...
November 2017: Israel Journal of Chemistry
https://www.readbyqxmd.com/read/29450902/identification-and-expression-profiles-of-novel-odorant-binding-proteins-and-functional-analysis-of-obp99a-in-bactrocera-dorsalis
#4
Jing Zhang, Deye Luo, Peng Wu, Haozhe Li, Hongyu Zhang, Weiwei Zheng
Odorant-binding proteins (OBPs) in insects are essential for mating and oviposition host selection. How these OBPs respond to different hosts at the mRNA level and their effects on behavior remain poorly characterized. The oriental fruit fly Bactrocera dorsalis is a highly invasive agricultural pest with an extremely broad host range and high fecundity. Based on our previously constructed B. dorsalis transcriptome, six OBPs that were differentially expressed during three different physiological adult stages were identified...
February 16, 2018: Archives of Insect Biochemistry and Physiology
https://www.readbyqxmd.com/read/29446933/dietary-sodium-butyrate-supplementation-reduces-high-concentrate-diet-feeding-induced-apoptosis-in-mammary-cells-in-dairy-goats
#5
Guangjun Chang, Jinyu Yan, Nana Ma, Xinxin Liu, Hongyu Dai, Muhammad Shaid Bilal, Xiangzhen Shen
Eighteen lactating goats (38.86 ± 2.06 kg) were randomly allocated to three groups. One group was fed a low-concentrate (LC) diet (forage:concentrate = 6:4, LC), while the other two groups were fed a high-concentrate (HC) diet (forage:concentrate = 4:6, HC) or an HC diet supplemented with sodium butyrate (BHC) for 20 weeks. Samples of ruminal fluid, milk, hepatic blood plasma, and mammary gland tissue were prepared for the experimental analysis. The LPS concentration, caspase-3 and -8 enzymatic activity, caspase-3 and -8 mRNA expression, and NF-κB (p65), phosphorylated-p65, bax, cytochrome C, and caspase-3 protein expression were higher in the HC group than those in the LC group; however, the levels of these parameters were lower in the BHC group than those in the HC group...
February 15, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29435276/serum-osteopontin-is-a-predictor-of-prognosis-for-hbv-associated-acute-on-chronic-liver-failure
#6
Longgen Liu, Jianchun Lu, Chunyan Ye, Lin Lin, Shuqin Zheng, Hongyu Zhang, Qing Lan, Yuan Xue
Acute-on-chronic liver failure (ACLF) is a syndrome with a high rate of short-term mortality, and clinically it is important to identify patients at high risk of mortality. The present study evaluated the value of osteopontin (OPN) in the prediction of 90-day mortality in patients with ACLF. A total of 54 patients with HBV-associated ACLF were enrolled, and serum OPN levels were determined in a prospective, observational study design. Survival analysis was performed using Kaplan-Meier curves, and multivariate Cox proportional hazards regression was used to analyze independent risk factors of mortality...
February 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29434230/comparing-the-similarity-and-difference-of-three-influenza-surveillance-systems-in-china
#7
Xiaoting Yang, Dongpeng Liu, Kongfu Wei, Xinfeng Liu, Lei Meng, Deshan Yu, Hongyu Li, Baodi Li, Jian He, Wenbiao Hu
Three main surveillance systems (laboratory-confirmed, influenza-like illness (ILI) and nationwide Notifiable Infectious Diseases Reporting Information System (NIDRIS)) have been used for influenza surveillance in China. However, it is unclear which surveillance system is more reliable in developing influenza early warning system based on surveillance data. This study aims to evaluate the similarity and difference of the three surveillance systems and provide practical knowledge for improving the effectiveness of influenza surveillance...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29433422/the-effect-of-noise-exposure-on-insulin-sensitivity-in-mice-may-be-mediated-by-the-jnk-irs1-pathway
#8
Lijie Liu, Cong Fang, Jing Yang, Hongyu Zhang, Yi Huang, Chuanying Xuan, Yongfang Wang, Shengwei Li, Jun Sha, Mingming Zha, Min Guo
BACKGROUND: Epidemiological studies have suggested that noise exposure may increase the risk of type 2 diabetes mellitus (T2DM), and experimental studies have demonstrated that noise exposure can induce insulin resistance in rodents. The aim of the present study was to explore noise-induced processes underlying impaired insulin sensitivity in mice. METHODS: Male ICR mice were randomly divided into four groups: a control group without noise exposure and three noise groups exposed to white noise at a 95-dB sound pressure level for 4 h/day for 1, 10, or 20 days (N1D, N10D, and N20D, respectively)...
February 12, 2018: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29432514/improving-snp-prioritization-and-pleiotropic-architecture-estimation-by-incorporating-prior-knowledge-using-graph-gpa
#9
Hang J Kim, Zhenning Yu, Andrew Lawson, Hongyu Zhao, Dongjun Chung, Oliver Stegle
Availability: graph-GPA is implemented as an R package 'GGPA', which is publicly available at http://dongjunchung.github.io/GGPA/. DDNet, a web interface to query diseases of interest and download a prior disease graph obtained from a text mining of biomedical literature, is publicly available at http://www.chunglab.io/ddnet/. Contact: chungd@musc.edu. Supplementary information: Supplementary data are available at Bioinformatics online.
February 8, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29429126/individual-susceptibility-to-arsenic-induced-diseases-the-role-of-host-genetics-nutritional-status-and-the-gut-microbiome
#10
REVIEW
Liang Chi, Bei Gao, Pengcheng Tu, Chih-Wei Liu, Jingchuan Xue, Yunjia Lai, Hongyu Ru, Kun Lu
Arsenic (As) contamination in water or food is a global issue affecting hundreds of millions of people. Although As is classified as a group 1 carcinogen and is associated with multiple diseases, the individual susceptibility to As-related diseases is highly variable, such that a proportion of people exposed to As have higher risks of developing related disorders. Many factors have been found to be associated with As susceptibility. One of the main sources of the variability found in As susceptibility is the variation in the host genome, namely, polymorphisms of many genes involved in As transportation, biotransformation, oxidative stress response, and DNA repair affect the susceptibility of an individual to As toxicity and then influence the disease outcomes...
February 10, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/29428623/modified-repair-of-type-i-and-ii-truncus-arteriosus-limits-early-right-ventricular-outflow-tract-re-operation
#11
Clauden Louis, Michael F Swartz, Bartholomew V Simon, Jill M Cholette, Nader Atallah-Yunes, Hongyue Wang, Francisco Gensini, George M Alfieris
OBJECTIVE: Repair of truncus arteriosus often requires early right ventricular outflow tract (RVOT) re-operation. Using a modified repair the branch pulmonary arteries are left in-situ, which may avoid earlier RVOT reoperation. We hypothesized that our modified repair for Type I and II truncus arteriosus would extend the time to RVOT re-operation. METHODS: Infants with truncus arteriosus were divided into two groups: A) Traditional technique where the branch pulmonary arteries are excised from the truncal root, or B) Modified repair where the branch pulmonary arteries are left in-situ and septated from the truncal root...
February 8, 2018: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29427062/identification-of-new-type-i-interferon-stimulated-genes-and-investigation-of-their-involvement-in-ifn-%C3%AE-activation
#12
Xiaolin Zhang, Wei Yang, Xinlu Wang, Xuyuan Zhang, Huabin Tian, Hongyu Deng, Liguo Zhang, Guangxia Gao
Virus infection induces the production of type I interferons (IFNs). IFNs bind to their heterodimeric receptors to initiate downstream cascade of signaling, leading to the up-regulation of interferon-stimulated genes (ISGs). ISGs play very important roles in innate immunity through a variety of mechanisms. Although hundreds of ISGs have been identified, it is commonly recognized that more ISGs await to be discovered. The aim of this study was to identify new ISGs and to probe their roles in regulating virus-induced type I IFN production...
February 9, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29423029/recombinant-frizzled1-protein-attenuated-cardiac-hypertrophy-after-myocardial-infarction-via-the-canonical-wnt-signaling-pathway
#13
Jingjing Fan, Lin Qiu, Hongyang Shu, Ben Ma, Marco Hagenmueller, Johannes H Riffel, Soeren Meryer, Min Zhang, Stefan E Hardt, Lin Wang, Dao Wen Wang, Hongyu Qiu, Ning Zhou
Postinfarct cardiac hypertrophy is an independent risk factor for heart failure and sudden death. Regression of cardiac hypertrophy has emerged as a promising strategy in the treatment of myocardial infarction (MI). Here we hypothesized that frizzled1 (FZD1), a receptor of the canonical Wnt signaling pathway, is a novel mediator of ischemia-associated cardiac hypertrophy. MI was induced in mice by left anterior descending (LAD) coronary occlusion. One week after MI, the expression of FZD1 was found to be notably increased in the left ventricles (LVs) of the MI-mice compared to shams...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29414653/mrna-chip-based-analysis-on-transcription-factor-regulatory-network-central-nodes-of-protection-targets-of-deproteinized-extract-of-calf-blood-on-acute-liver-injury-in-mice
#14
Guangyu Xu, Jinhe Xu, Xiao Han, Hongyu Li, Guangxin Yuan, Liping An, Peige Du
Our previous study found that Deproteinized Extract of Calf Blood (DECB) could protect the acute liver injury induced by carbon tetrachloride in mice, but the target-related transcription factors and their regulatory networks were not comprehensively studied. Based on the mRNA expression microarray data obtained in the previous study, the mRNA transcription factor regulatory networks were constructed by screening the transcription factors of differentially expressed genes and their corresponding target proteins, and the analysis on the functions and pathways of the regulatory network central nodes was performed...
January 27, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29414364/association-patterns-for-size-fractioned-indoor-particulate-matter-and-black-carbon-and-autonomic-function-differ-between-patients-with-chronic-obstructive-pulmonary-disease-and-their-healthy-spouses
#15
Lu Pan, Wei Dong, Hongyu Li, Mark R Miller, Yahong Chen, Miranda Loh, Shaowei Wu, Junhui Xu, Xuan Yang, Masayuki Shima, Furong Deng, Xinbiao Guo
BACKGROUND: The effect of health status on the relationship between particulate matter (PM) and black carbon (BC) and cardiac autonomic function has not been examined sufficiently directly comparing patients with healthy participants. OBJECTIVES: To evaluate the association patterns between size-fractioned indoor PM and BC and cardiac autonomic function in chronic obstructive pulmonary disease (COPD) patients and their healthy spouses. METHODS: Twenty-four-hour heart rate variability (HRV) and heart rate (HR) was measured in eight pairs of stable COPD patients and their healthy spouses...
January 26, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29408870/mid-term-outcomes-of-biventricular-obstruction-and-left-ventricular-outflow-tract-obstruction-after-surgery-correction-in-child-and-adolescent-patients-with-hypertrophic-cardiomyopathy
#16
Shanshan Zhai, Haitao Xu, Chaomei Fan, Yinjian Yang, Fei Hang, Xiying Guo, Hongyue Wang, Fujian Duan, Jun Yan
BACKGROUND: Data on the outcomes of hypertrophic cardiomyopathy (HCM) with biventricular obstruction are limited. OBJECTIVE: Our aim is to compare mid-term outcomes of biventricular outflow tract obstruction (BVOTO) HCM, left ventricular outflow tract obstruction (LVOTO) HCM and nonobstructive hypertrophic cardiomyopathy (NO-HCM) in children and adolescents who were treated with standard medication or surgical resection. METHODS: This retrospective study identified 21 BVOTO patients and recruited 27 LVOTO and 24 NO-HCM patients younger than 18 years presenting at our institution...
2018: PloS One
https://www.readbyqxmd.com/read/29404669/clinical-and-magnetic-resonance-imaging-assessment-of-anatomical-lateral-ankle-ligament-reconstruction-comparison-of-tendon-allograft-and-autograft
#17
Qianru Li, Kui Ma, Hongyue Tao, Yinghui Hua, Shuang Chen, Shiyi Chen, Yutong Zhao
PURPOSE: To compare the results of anatomical lateral ankle ligament (LAL) reconstruction with tendon allograft and autograft using clinical scores and ultrashort echo time (UTE) sequence of MRI. METHODS: A total of 26 patients with LAL reconstruction were recruited in this study, including 16 using semitendinosus allografts and 10 using semitendinosus autograft. All of them were diagnosed as chronic ankle instability and accepted anatomic reconstruction. The American Orthopedic Foot and Ankle Society (AOFAS) score, Karlsson score, and radiological evaluation using MRI UTE scanning were extracted from each patient...
February 5, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29401587/endoglin-interacts-with-vegfr2-to-promote-angiogenesis
#18
Hongyu Tian, Jennifer J Huang, Christelle Golzio, Xia Gao, Melissa Hector-Greene, Nicholas Katsanis, Gerard C Blobe
Endoglin, a TGF-β coreceptor predominantly expressed in endothelial cells, plays an important role in vascular development and tumor-associated angiogenesis. However, the mechanism by which endoglin regulates angiogenesis, especially during tip cell formation, remains largely unknown. In this study, we report that endoglin promoted VEGF-induced tip cell formation. Mechanistically, endoglin interacted with VEGF receptor (VEGFR)-2 in a VEGF-dependent manner, which sustained VEGFR2 on the cell surface and prevented its degradation...
January 11, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29399694/mechanisms-of-the-cdk4-6-inhibitor-palbociclib-pd-0332991-and-its-future-application-in-cancer-treatment-review
#19
Minghui Liu, Hongyu Liu, Jun Chen
An uncontrolled cell cycle is an obvious marker of tumor cells. The G1‑S phase is an important restriction point in the normal cell cycle, but in cancer cells the restriction function is reduced, leading to uncontrolled cell proliferation. Two cyclin‑dependent kinases (CDKs), CDK4 and CDK6, play a crucial role in the G1‑S phase transition. Inhibitors of CDK4/6 are presently the subjects of numerous studies, and PD 0332991, an inhibitor of CDK4/6, has been used to treat hormone receptor (HR)‑positive, advanced‑stage breast cancer...
January 19, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29399648/insights-into-key-interactions-between-vancomycin-and-bacterial-cell-wall-structures
#20
Feng Wang, Hongyu Zhou, Olatunde P Olademehin, Sung Joon Kim, Peng Tao
Vancomycin is a glycopeptide antibiotic used for the treatment of serious infections by Gram-positive pathogens. Vancomycin inhibits cell wall biosynthesis by targeting the d-Ala-d-Ala terminus of peptidoglycan (PG). The highly cross-linked heptapeptide aglycon structure of vancomycin is the d-Ala-d-Ala binding site. The first residue of vancomycin is N-methyl-leucine, which is crucial for the dipeptide binding. The removal of N-methyl-leucine by Edman degradation results in desleucyl-vancomycin devoid of antimicrobial activities...
January 31, 2018: ACS Omega
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