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https://www.readbyqxmd.com/read/28735505/role-of-infarct-location-and-pre-existing-depression-on-cardiac-baroreceptor-sensitivity-in-subacute-ischemic-stroke
#1
Aurelie De Vos, Jacques De Keyser, Sylvie De Raedt
Reduced cardiac baroreceptor sensitivity (BRS) after acute stroke is associated with worse outcome. The underlying mechanisms of reduced BRS are unclear. We evaluated cross correlation BRS (xBRS) in 184 patients with suspected acute ischemic stroke within 72 h of symptom onset. Among these patients, 22 had a transient ischemic attack (TIA) and 27 had a stroke mimic. Sixty-four age- and sex-matched ambulant control subjects without stroke were included. Compared with controls, xBRS was significantly lower in patients with ischemic stroke, TIA, and stroke mimics (4...
July 22, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28735302/autopsy-interrogation-of-emergency-medicine-dispute-cases-how-often-are-clinical-diagnoses-incorrect
#2
Danyang Liu, Rongchang Gan, Weidi Zhang, Wei Wang, Hexige Saiyin, Wenjiao Zeng, Guoyuan Liu
AIMS: Emergency medicine is a 'high risk' specialty. Some diseases develop suddenly and progress rapidly, and sudden unexpected deaths in the emergency department (ED) may cause medical disputes. We aimed to assess discrepancies between antemortem clinical diagnoses and postmortem autopsy findings concerning emergency medicine dispute cases and to figure out the most common major missed diagnoses. METHODS: Clinical files and autopsy reports were retrospectively analysed and interpreted...
July 22, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28735289/prolonged-fever-after-st-segment-elevation-myocardial-infarction-and-long-term-cardiac-outcomes
#3
Chika Kawashima, Yasushi Matsuzawa, Eiichi Akiyama, Masaaki Konishi, Hiroyuki Suzuki, Katsutaka Hashiba, Toshiaki Ebina, Masami Kosuge, Kiyoshi Hibi, Kengo Tsukahara, Noriaki Iwahashi, Nobuhiko Maejima, Kentaro Sakamaki, Satoshi Umemura, Kazuo Kimura, Kouichi Tamura
BACKGROUND: The biphasic inflammation after ST-segment elevation myocardial infarction (STEMI) plays an important role in myocardial healing and progression of systemic atherosclerosis. The purpose of this study is to investigate the impact of fever during the first and second phases of post-STEMI inflammation on long-term cardiac outcomes. METHODS AND RESULTS: A total of 550 patients with STEMI were enrolled in this study. Axillary body temperature (BT) was measured and maximum BTs were determined for the first (within 3 days: max-BT1-3d) and second (from 4 to 10 days after admission: max-BT4-10d) phases, respectively...
July 22, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28735256/comparison-of-multimodal-intra-arterial-treatment-versus-intravenous-thrombolysis-for-hypertensive-patients-with-severe-large-vessel-cerebral-infarction
#4
Zuojun Tian, Geng Liao, Shaoming Li, Yuechun Shen, Changbing Chen, Lei Liu, Yiheng Li
Since intravenous thrombolysis (IVT) is often associated with poor outcomes in hypertensive patients with severe acute cerebral infarction (ACI) due to occlusions of the internal carotid, basilar, or proximal middle cerebral artery, we evaluated whether multimodal intra-arterial treatment (IAT) might improve functional outcomes in this patient population. We retrospectively reviewed the charts of eligible patients who underwent multimodal IAT including intra-arterial thrombolysis, mechanical thrombectomy, balloon and/or stent angioplasty (IAT group) or IVT alone (IVT group)...
July 21, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28735240/therapeutic-effects-of-l-cysteine-in-newborn-mice-subjected-to-hypoxia-ischemia-brain-injury-via-the-cbs-h2s-system-role-of-oxidative-stress-and-endoplasmic-reticulum-stress
#5
Song Liu, Danqing Xin, Lingxiao Wang, Tiantian Zhang, Xuemei Bai, Tong Li, Yunkai Xie, Hao Xue, Shishi Bo, Dexiang Liu, Zhen Wang
Neonatal hypoxic-ischemic (HI) injury is a major cause of neonatal death and neurological dysfunction. H2S has been shown to protect against hypoxia-induced injury and apoptosis of neurons. L-Cysteine is catalyzed by cystathionine-β-synthase (CBS) in the brain and sequentially produces endogenous H2S. The present study was designed to investigate whether L-Cysteine could attenuate the acute brain injury and improve neurobehavioral outcomes following HI brain injury in neonatal mice by releasing endogenous H2S...
July 14, 2017: Redox Biology
https://www.readbyqxmd.com/read/28735151/do-air-pollution-and-neighborhood-greenness-exposures-improve-the-predicted-cardiovascular-risk
#6
Maayan Yitshak-Sade, Itai Kloog, Victor Novack
BACKGROUND: Numerous studies show associations between exposure to Particulate Matter and Cardiovascular disease (CVD). Current cardiovascular equations incorporate the major risk factors for CVD. The patients' environment, however, is not incorporated in these equations. METHODS: In a retrospective analysis, we assessed the contribution of neighborhood greenness and particulate matter (coarse-PM and PM<2.5μm-PM2.5) to the development of CVD by analyzing the change in prediction abilities...
July 20, 2017: Environment International
https://www.readbyqxmd.com/read/28735140/isolated-subcallosal-artery-infarction-secondary-to-localised-cerebral-vasospasm-of-anterior-communicating-artery-complex-following-subarachnoid-haemorrhage
#7
Santhosh Kumar Kannath, Virender Malik, Jayadevan Enakshy Rajan
BACKGROUND: Subcallosal artery (ScA) infarction is a well-recognised, but uncommon complication of surgical treatment of anterior communicating artery (ACOM) aneurysms. CASE DESCRIPTION: An elderly man presented with massive subarachnoid haemorrhage due to left posterior communicating artery aneurysm with thick clots in the anterior interhemispheric fissure. The aneurysm was coiled with balloon protection and later, on the fifth day of ictus, the patient became acutely confused and developed memory disturbances...
July 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28735014/initial-clinical-experience-with-testosterone-undecanoate-therapy-aveed-%C3%A2-in-testosterone-deficient-men-in-the-united-states
#8
Abraham Morgentaler, Yonah Krakowsky, William Conners, Emily Davidson, Alex Rawji
OBJECTIVE: To report our initial experiences with TU 750mg in testosterone-deficient men. METHODS: All patients receiving TU 750mg at our center between July 1 2014 to August 1 2016 were identified. Clinical response was assessed via structured interviews and laboratory evaluations. Adverse events were documented, including increases in prostate specific antigen (PSA), hematocrit (Hct), and the development of post-injection cough. RESULTS: More than two injections were received by 147 men, with mean age 63...
July 19, 2017: Urology
https://www.readbyqxmd.com/read/28734938/hepatitis-e-virus-infection-and-acute-non-traumatic-neurological-injury-a-prospective-multicentre-study
#9
Harry R Dalton, Jeroen J J van Eijk, Pascal Cintas, Richie G Madden, Catherine Jones, Glynn W Webb, Benjamin Norton, Julie Pique, Suzanne Lutgens, Nikki Devooght-Johnson, Kathy Woolson, John Baker, Maria Saunders, Liz Househam, James Griffiths, Florence Abravanel, Jacques Izopet, Nassim Kamar, Nens van Alfen, Baziel G M van Engelen, Jeremy G Hunter, Annemiek A van der Eijk, Richard P Bendall, Brendan N Mclean, Bart C Jacobs
BACKGROUND AND AIMS: HEV has been associated with a number of neurological syndromes, but causality has not yet been established. AIM: to explore the relationship between HEV and neurological illness by prospective HEV-testing of patients presenting with acute non-traumatic neurological injury. METHODS: 464 consecutive patients presenting to hospital with acute non-traumatic neurological illnesses were tested for HEV by serology and PCR from 4 centres in the UK, France and the Netherlands...
July 19, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28734926/derivation-and-evaluation-of-age-specific-multivariate-reference-regions-to-aid-in-identification-of-abnormal-filling-patterns-the-hunt-and-vamis-studies
#10
Jonas Selmeryd, Egil Henriksen, Håvard Dalen, Pär Hedberg
OBJECTIVES: This study aimed to derive age-specific multivariate reference regions (MVRs) able to classify subjects into those having normal or abnormal filling patterns and to evaluate the prognostic impact of this classification. BACKGROUND: The integration of several parameters is necessary to diagnose disorders of left ventricular (LV) filling because no single measurement accurately describes the complexity of diastolic function. However, no generally accepted validated multiparametric algorithm currently exists...
July 13, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28734921/imaging-ischemic-and-reperfusion-injury-in-acute-myocardial-infarction-putting-the-pieces-together-with-cmr
#11
Jan Bogaert, Davide Curione, Pedro Morais, Manuel Barreiro-Perez, Sofie Tilborghs, Frederik Maes, Tom Dresselaers
No abstract text is available yet for this article.
July 13, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28734913/uncovered-culprit-plaque-ruptures-in-patients-with-st-segment-elevation-myocardial-infarction-assessed-by-optical-coherence-tomography-and-intravascular-ultrasound-with-imap
#12
Mikkel Hougaard, Henrik Steen Hansen, Per Thayssen, Lisbeth Antonsen, Lisette Okkels Jensen
OBJECTIVES: This study assessed the incidence and course of healing of uncovered plaque ruptures (PR) following primary percutaneous coronary intervention. BACKGROUND: The infarct-related occlusion is frequently located at the lesion site with maximum thrombus burden, whereas the culprit PR may be situated more proximally or distally. METHODS: Uncovered PR in segments adjacent to the stent were identified by optical coherence tomography and intravascular ultrasound using iMap (Boston Scientific, Marlborough, Massachusetts) within 48 h and after 12 months...
July 13, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28734911/plaque-rupture-in-coronary-atherosclerosis-is-associated-with-increased-plaque-structural-stress
#13
Charis Costopoulos, Yuan Huang, Adam J Brown, Patrick A Calvert, Stephen P Hoole, Nick E J West, Jonathan H Gillard, Zhongzhao Teng, Martin R Bennett
OBJECTIVES: The aim of this study was to identify the determinants of plaque structural stress (PSS) and the relationship between PSS and plaques with rupture. BACKGROUND: Plaque rupture is the most common cause of myocardial infarction, occurring particularly in higher risk lesions such as fibroatheromas. However, prospective intravascular ultrasound-virtual histology studies indicate that <10% higher risk plaques cause clinical events over 3 years, indicating that other factors also determine plaque rupture...
July 13, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28734575/outcomes-associated-to-serum-phosphate-levels-in-patients-with-suspected-acute-coronary-syndrome
#14
Hong Xu, Marie Evans, Alessandro Gasparini, Karolina Szummer, Jonas Spaak, Johan Ärnlöv, Bengt Lindholm, Tomas Jernberg, Juan Jesús Carrero
BACKGROUND: We investigated the association between phosphate and the risk of adverse clinical outcomes in patients with manifest cardiovascular disease (CVD). METHODS: Observational study of patients hospitalized during 2006-2011 in Stockholm, Sweden, because of suspected acute coronary syndrome (ACS). The exposure was serum phosphate during the hospitalization. We modeled the association between phosphate and in-hospital death or in-hospital events (composite of myocardial infarction, cardiogenic shock, resuscitated cardiac arrest, atrial fibrillation, or atrioventricular block) as well as the one-year post-discharge risk of death or cardiovascular event (composite of myocardial re-infarction, heart failure and stroke)...
July 17, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28734463/usefulness-of-elevated-levels-of-growth-differentiation-factor-15-to-classify-patients-with-acute-coronary-syndrome-having-percutaneous-coronary-intervention-who-would-benefit-from-high-dose-statin-therapy
#15
Ioannis Tentzeris, Serdar Farhan, Matthias Karl Freynhofer, Miklos Rohla, Rudolf Jarai, Birgit Vogel, Sabina Baumgartner-Parzer, Michael Nürnberg, Alexander Geppert, Emil Wessely, Johann Wojta, Kurt Huber, Alexandra Kautzky-Willer
The aim of this study was to evaluate whether growth differentiation factor-15 (GDF-15) plasma concentration at the time of percutaneous coronary intervention (PCI) might help identify those patients with acute coronary syndrome (ACS), who benefit most from high-dose statin treatment. Two hundred eighty-four consecutive patients, who underwent percutaneous coronary intervention (PCI) for ACS, were included in a prospective registry. The combined end point at 3 months after PCI consisted of cardiovascular death, nonfatal myocardial infarction, and unstable angina...
June 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28734428/rupture-of-anterolateral-papillary-muscle-resulting-from-small-artery-occlusion
#16
Tomoki Sakata, Kenji Mogi, Manabu Sakurai, Anan Nomura, Masahiko Fujii, Shinichiro Shimizu, Yoshiharu Takahara
A 69-year-old man was admitted to our hospital for dyspnea and fever. Echocardiography showed a mobile mass on the anterolateral papillary muscle and severe mitral regurgitation. Coronary artery angiography showed no stenotic lesion. Infective endocarditis or cardiac tumor was suspected, and a mitral valve operation was performed. Intraoperative observation revealed a partially ruptured anterolateral papillary muscle and no evidence of infection or tumor. Pathologic examination of the resected papillary muscle showed atherosclerotic changes in small arteries and infarcted areas in different postinfarct time phases along the ruptured edge...
August 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28733995/incidence-predictors-and-clinical-outcomes-of-early-stent-thrombosis-in-acute-myocardial-infarction-patients-treated-with-primary-percutaneous-coronary-angioplasty-insights-from-the-university-of-ottawa-heart-institute-stemi-registry
#17
Kuljit Singh, Mohammed Rashid, Derek Y So, Christopher A Glover, Michael Froeschl, Benjamin Hibbert, Aun-Yeong Chong, Alexander Dick, Marino Labinaz, Michel Le May
BACKGROUND: Early stent thrombosis (ST) remains an important complication of primary percutaneous intervention (PCI). To date, our information on angiographic and clinical predictors of early ST in ST-segment elevation myocardial infarction (STEMI) patients treated with primary PCI is limited. METHODS: We tried to evaluate the incidence, predictors, and outcomes of early ST in real-world patients treated with primary PCI. We identified all the patients presenting with STEMI between June 2004 and January 2011 who underwent primary PCI as the primary mode of revascularization...
July 22, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28733974/impact-of-diabetes-mellitus-on-procedural-and-one-year-clinical-outcomes-following-treatment-of-severely-calcified-coronary-lesions-with-the-orbital-atherectomy-system-a-subanalysis-of-the-orbit-ii-study
#18
Michael S Lee, Brad J Martinsen, Arthur C Lee, Ann N Behrens, Richard A Shlofmitz, Christopher Y Kim, Jeffrey W Chambers
OBJECTIVES: The goal of the study was to investigate the safety and efficacy of the coronary orbital atherectomy system to treat severe coronary artery calcification (CAC) prior to stent placement in diabetic and non-diabetic patients. BACKGROUND: The ORBIT II study reported the safety and efficacy of orbital atherectomy treatment in 443 patients with severe CAC. Percutaneous coronary intervention in diabetic patients is associated with an increased risk of major adverse cardiac events (MACE) compared with non-diabetics...
July 22, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28733741/tips-and-tricks-of-splenic-vessel-preservation-during-laparoscopic-distal-pancreatectomy
#19
Claire Goumard, Satoshi Ogiso, Masayuki Okuno, Jason B Fleming, Michael Kim, Ching-Wei D Tzeng, Jean-Nicolas Vauthey, Jeffrey E Lee, Claudius Conrad
BACKGROUND: While a laparoscopic approach can minimize postoperative morbidity in splenic vessel preserving (SVP) distal pancreatectomy (DP), this procedure can be technically challenging. A systematic approach to SVP minimizes the chances of vascular injury and maximizes the chances of successful splenic preservation. This video demonstrates a laparoscopic DP with SVP, highlighting technical tips and tricks that optimize the chances for SVP. PATIENT: The patient is a 14-year-old male with an incidentally discovered pancreatic tail mass...
July 21, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28733740/laparoscopic-splenopexy-for-wandering-spleen-a-video-demonstration-of-technique-by-encircling-the-spleen-with-polyglactin-910-woven-mesh
#20
Sheridan Morgan, Ian Glenn, Oliver Soldes
BACKGROUND: Wandering spleen is a rare clinical entity caused by absence of the spleen's peritoneal attachments, allowing the spleen to move freely within the peritoneal cavity [1]. This disease is most commonly seen in children and young women [1, 2]. Affected individuals are predisposed to complications including splenic torsion, splenic infarction, and pancreatic necrosis [3, 4]. Patients may present with constipation, an abdominal mass, swelling, or acute abdominal pain if splenic torsion has occurred [4]...
July 21, 2017: Surgical Endoscopy
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