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https://www.readbyqxmd.com/read/29656429/citalopram-attenuated-neurobehavioral-biochemical-and-metabolic-alterations-in-transient-middle-cerebral-artery-occlusion-model-of-stroke-in-male-wistar-rats
#1
Sangeetha Gupta, Deepti Upadhayay, Uma Sharma, Naranamangalam R Jagannathan, Yogendra Kumar Gupta
Oxidative stress and inflammation are implicated as cardinal mechanisms of neuronal death following stroke. In the present study citalopram (Cit) was investigated in a 2 h middle cerebral artery occlusion (MCAo) model of stroke in male Wistar rats. Pretreatment, posttreatment (Post Cit) and pre plus posttreatment (Pre + Post Cit) with Cit were evaluated for its neuroprotective effect. In pretreatment protocol, effect of Cit at three doses (2, 4, and 8 mg/kg) administered i.p., 1 h prior to MCAo was evaluated using neurological deficit score (NDS), motor deficit paradigms, and cerebral infarction 24 h post-MCAo...
April 15, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29656359/myocardial-infarct-size-reduction-provided-by-local-and-remote-ischaemic-preconditioning-references-values-from-the-hatter-cardiovascular-institute
#2
Xavier Rossello, Zhenhe He, Derek M Yellon
PURPOSE: To accurately estimate the effect size of both local or classic ischaemic preconditioning (IPC) and remote ischaemic preconditioning (RIPC) using a pooling data set of 91 animals. METHODS: We combined all the available mouse data collected from our Institute over the last 3 years regarding (i) local IPC (4 cycles of 5 min of global ischaemia/reperfusion injury, IRI, followed by 35-min ischaemia and 2-h reperfusion) in the Langendorff-isolated perfused mouse heart model and (ii) RIPC (3 cycles of 5 min of limb occlusion followed by 40-min ischaemia and 2-h reperfusion) in the in vivo mouse model...
April 14, 2018: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29656281/treatment-of-very-small-de-novo-coronary-artery-disease-with-2-0-mm-drug-coated-balloons-showed-1-year-clinical-outcome-comparable-with-2-0-mm-drug-eluting-stents
#3
Hui Wen Sim, Rajiv Ananthakrishna, Siew Pang Chan, Adrian F Low, Chi-Hang Lee, Mark Y Chan, Edgar L Tay, Poay Huan Loh, Koo Hui Chan, Huay Cheem Tan, Joshua P Loh
OBJECTIVE: To evaluate the 1-year clinical outcomes of patients treated with 2.0 mm drug-coated balloon (DCB) vs 2.0 mm drug-eluting stent (DES) implantation in small-caliber vessel de novo coronary artery disease (CAD). METHODS: All patients treated with 2.0 mm DCB or 2.0 mm DES for very small vessel de novo CAD from July 2014 to June 2016 were included in this study. The primary endpoint was the occurrence of target-lesion failure (TLF) and time to TLF, defined as a combination of cardiac mortality, target-vessel myocardial infarction, and target-lesion revascularization (TLR)...
April 15, 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29656279/drug-eluting-resorbable-magnesium-scaffold-implantation-in-st-segment-elevation-myocardial-infarction-a-pilot-study
#4
Quentin de Hemptinne, Fabien Picard, Rachid Briki, Ahmad Awada, Paul-Gaël Silance, Dariouch Dolatabadi, Nadia Debbas, Philippe Unger
OBJECTIVES: To assess feasibility and short-term clinical outcomes associated with resorbable magnesium scaffold (RMS) implantation in the setting of primary percutaneous coronary intervention for ST-segment elevation myocardial infarction (STEMI). BACKGROUND: RMS implantation has demonstrated favorable clinical outcomes in stable coronary artery disease patients. However, to date, data are lacking in the setting of STEMI. METHODS: This is a single-center prospective non-randomized pilot study...
April 15, 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29656154/acute-recanalization-of-a-partially-thrombosed-large-intracranial-aneurysm
#5
E Atallah, E Valle-Giler, T Elarjani, N Chalouhi, S Tjoumakaris, R H Rosenwasser, N Herial, M R Gooch, H Zarzour, P Jabbour
BACKGROUND: Thrombosed large intracranial aneurysms(TLIAs) are not continuously contemplated as stable lesions. Completely occluded large IAs' spontaneous recanalization has been previously described. CASE DESCRIPTION: We report the case of a middle-aged patient presenting with agitation, acute headache, visual field defects and left hemiparesis. A large thrombosed Posterior Communicating (PCom) artery aneurysm was identified with an infarct at the same arterial territory on neuroimaging studies...
April 12, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29655978/sitagliptin-prevents-isoproterenol-induced-myocardial-infarction-in-rats-by-modulating-nitric-oxide-synthase-enzymes
#6
Mohamed Abdellah Ibrahim, Ayman Geddawy, Soha Abdel-Wahab
Ischemic heart disease is a common cause of mortality worldwide. Sitagliptin is a new anti-diabetic drug acting as dipeptidyl peptidase-4 (DPP-4) inhibitor. The study investigated the ability of sitagliptin to prevent pathological changes of isoproterenol- (ISO-) induced myocardial injury in rats. The role of nitric oxide (NO) was also reported. Rats were assorted into six groups (n = 7) and treated for 12 days. Group 1: normal control, received normal saline. Group 2, sitagliptin control, received sitagliptin (10mg/kg, orally)...
April 12, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29655952/population-level-incidence-and-outcomes-of-myocardial-infarction-with-non-obstructive-coronary-arteries-minoca-insights-from-the-alberta-contemporary-acute-coronary-syndrome-patients-invasive-treatment-strategies-coapt-study
#7
Kevin R Bainey, Robert C Welsh, Wendimagegn Alemayehu, Cynthia M Westerhout, Dean Traboulsi, Todd Anderson, Neil Brass, Paul W Armstrong, Padma Kaul
BACKGROUND: Myocardial infarction with non-obstructive coronary arteries (MINOCA) is a known clinical conundrum with limited investigation. Using a large population-based cohort, we examined the incidence, demographic profile, use of evidence-based medicines (EBM) and clinical outcomes of MINOCA patients. METHODS: Patients hospitalized with a primary diagnosis of MI who underwent coronary angiography between 01/04/2002 and 31/03/2014 in Alberta, Canada, were included in the study...
April 4, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29655951/acef-score-adapted-to-st-elevation-myocardial-infarction-patients-the-acef-stemi-score
#8
Martin Reindl, Sebastian Johannes Reinstadler, Christina Tiller, Markus Kofler, Markus Theurl, Nora Klier, Katherina Fleischmann, Agnes Mayr, Benjamin Henninger, Gert Klug, Bernhard Metzler
BACKGROUND: The age, creatinine and ejection fraction (ACEF) score has originally been developed for risk stratification of patients undergoing elective cardiac surgery. In patients with stable coronary artery disease treated by percutaneous coronary intervention (PCI), the prognostic accuracy of ACEF could be further improved by modifying the original scoring system (called "modified ACEF" or "ACEF-MDRD"). We aimed to specifically adapt the ACEF score for risk assessment of ST-elevation myocardial infarction (STEMI) patients...
April 6, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29655894/hhipl-1-rs2895811-gene-polymorphism-is-associated-with-cardiovascular-risk-factors-and-cardiometabolic-parameters-in-mexicans-patients-with-myocardial-infarction
#9
José Manuel Rodríguez-Pérez, Rosalinda Posadas-Sánchez, Ruben Blachman-Braun, Gilberto Vargas-Alarcón, Carlos Posadas-Romero, Adrián Asael Rodríguez-Cortés, Fabiola López-Bautista, Carlos Alfonso Tovilla-Zárate, Emma Xochitl Rojas-Toledo, Verónica Marusa Borgonio-Cuadra, Nonanzit Pérez-Hernández
Several studies have reported the role of hedgehog interacting protein-like 1 (HHIPL-1) in different pathologies, including cardiovascular disease. The aim of the present study was to analyze the association of HHIPL-1 (rs2895811) polymorphism with myocardial infarction (MI), cardiometabolic parameters, and traditional cardiovascular risk factors in the Mexican population. The polymorphism was genotyped using a TaqMan assay in 1023 patients with MI and 1105 controls. A similar distribution of the polymorphism was observed between studied groups...
April 12, 2018: Gene
https://www.readbyqxmd.com/read/29655881/racial-differences-in-quality-of-care-and-outcomes-after-acute-coronary-syndrome
#10
Celina M Yong, Leo Ungar, Freddy Abnousi, Steven M Asch, Paul A Heidenreich
Guideline adherence and variation in acute coronary syndrome (ACS) outcomes by race in the modern era of drug-eluting stents (DES) are not well understood. Previous studies also fail to capture rapidly growing minority populations, such as Asians. A retrospective analysis of 689,238 hospitalizations for ACS across all insurance types from 2008 to 2011 from the Healthcare Cost and Utilization Project database was performed to determine whether quality of ACS care and mortality differ by race (white, black, Asian, Hispanic, or Native American), with adjustment for patient clinical and demographic characteristics and clustering by hospital...
March 13, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29655880/efficacy-and-safety-of-the-heartmate-percutaneous-heart-pump-during-high-risk-percutaneous-coronary-intervention-from-the-shield-i-trial
#11
Dariusz Dudek, Adrian Ebner, Robert Sobczyński, Jarosław Trębacz, Boris Vesga, Juan Granada, Marian Zembala, Adam Witkowski, Nicolas M Van Mieghem, Poornima Sood, Andrzej Ochała, Artur Dziewierz, Krzysztof Żmudka
This study aimed to evaluate the use of the HeartMate percutaneous heart pump, a catheter-based axial flow pump designed to provide partial left ventricular support, in patients who underwent high-risk percutaneous coronary intervention (PCI). Patients who are hemodynamically unstable, or at risk of being hemodynamically unstable, while undergoing PCI may require mechanical circulatory support. Fifty high-risk patients were enrolled in a prospective, nonrandomized, multicenter, open-label trial. Primary end points were freedom from hemodynamic compromise during PCI and a composite measure of major adverse events...
March 13, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29655768/cell-free-dna-and-microvascular-damage-in-st-segment-elevation-myocardial-infarction-treated-with-primary-percutaneous-coronary-intervention
#12
Juan Sanchis, Sergio García-Blas, Luis Ortega-Paz, Ana Paula Dantas, Enrique Rodríguez, Lidia Abellán, Salvatore Brugaletta, Ernesto Valero, Gema Miñana, Manuel Garabito, África Corchón, Julio Núñez, Arturo Carratalá, Manel Sabaté
INTRODUCTION AND OBJECTIVES: Cell-free DNA (cfDNA) in ST-segment elevation myocardial infarction might originate from hyperactivated leukocytes at the coronary lesion. Our aim was to investigate the relationship between cfDNA and coronary reperfusion. METHODS: We studied 116 patients treated with primary angioplasty using thrombus aspiration. Coronary (during aspiration) and peripheral (at the end of the procedure) blood samples were drawn for cfDNA, as well as high-sensitivity troponin T and myeloperoxidase quantification...
April 11, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29655692/effects-of-xin-ji-er-kang-on-heart-failure-induced-by-myocardial-infarction-role-of-inflammation-oxidative-stress-and-endothelial-dysfunction
#13
Juan Hu, Pan Cheng, Guang-Yao Huang, Guo-Wei Cai, Feng-Zhen Lian, Xiao-Yun Wang, Shan Gao
BACKGROUND: Xin-Ji-Er-Kang (XJEK) is a Chinese herbal formula, which has been reported to exert effective protection on cardiovascular diseases like hypertension and myocarditis. PURPOSE: To elucidate the protective effects of XJEK on heart failure (HF) induced by myocardial infarction (MI) through the amelioration of inflammation, oxidative stress (OS) and endothelial dysfunction(ED). MATERIALS AND METHODS: Fifty-seven male KM mice were randomized into the following six groups (n = 9-10 for each): control group, model group, MI+XJEK low dose group(XJEKL) group, MI+XJEK middle dose group(XJEKM), MI+XJEK high dose group(XJEKH), and MI+fosinopril group (positive control group)...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29655684/protective-role-and-mechanism-of-snakegourd-peel-against-myocardial-infarction-in-rats
#14
Guanlin Yang, Dongyu Min, Junwei Yan, Ming Yang, Guijun Lin
BACKGROUND: Injection of snakegourd peel (SP), an herb used in traditional Chinese medicine, is used to treat coronary artery disease and stable angina in China. However, its therapeutic role and mechanism of action for the treatment of myocardial infarction (MI) is not fully understood. PURPOSE: The present study was designed to investigate the effect of SP on MI-induced cardiac injury and elucidate its underlying molecular mechanisms. METHODS: To create an in vivo model of MI, we ligated the left coronary artery of Wistar rats...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29655621/the-economic-burden-of-hypertension-heart-failure-myocardial-infarction-and-atrial-fibrillation-in-mexico
#15
Bryce Stevens, Lynne Pezzullo, Lara Verdian, Josh Tomlinson, Claudia Estrada-Aguilar, Alice George, Juan Verdejo-París
No abstract text is available yet for this article.
April 11, 2018: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/29655567/acute-coronary-syndrome-relationship-between-genetic-variants-and-timi-risk
#16
Viviane do Carmo Vasconcelos de Carvalho, Lílian Caroliny Amorim Silva, Romário Martins Araújo, Fábia Carla da Silva Soares, Maria José Ribeiro Bezerra, Sávio Augusto Vieira de Oliveira, Alex José de Melo Silva, Sérgio Tavares Montenegro, Roberto Pereira Werkhauser, Carlos Gustavo Régis da Silva, Adriana Vieira Gomes, Clarice Neuenschwander Lins de Morais, Silvia Maria Lucena Montenegro
Acute Coronary Syndrome (ACS) is a multifactorial disease, including the genetic factor, caused by coronary artery obstruction by atheroma. Some genetic variants have been described as risk factors for this disease. Its early diagnosis and stratification of risk of death by Thrombolysis in Myocardial Infarction (TIMI) are important. Therefore, we evaluated variants in the IL6R (c950-1722C>T), TNFa (c.-488G>A), LEPR (c.2673+1118C>T) and IL1b (c.-598T>C) genes in relation to TIMI risk, cytokine serum levels, and risk factors for ACS...
April 11, 2018: Cytokine
https://www.readbyqxmd.com/read/29655505/midterm-outcome-of-transcatheter-versus-surgical-aortic-valve-replacement-in-low-to-intermediate-risk-patients-a-meta-analysis-of-randomized-controlled-trials
#17
Yanwei Wang, Yijiang Zhou, Li Zhang, Jianhua Zhu
BACKGROUND: Current guidelines recommend transcatheter aortic valve replacement (TAVR) in patients with severe symptomatic aortic stenosis (AS) who are not suitable for conventional surgical aortic valve replacement (SAVR). In light of the recent trend in performing TAVR in patients with lower risk profile, we assessed the midterm outcome comparing TAVR and SAVR for the treatment of patients with severe AS at low to intermediate risk. METHODS: PubMed, EBSCO, and Cochrane CENTRAL were systematically searched for randomized controlled trials that reported the clinical outcomes of TAVR versus SAVR in patients at low to intermediate surgical risk with at least 2 years of follow-up...
June 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29655487/frequency-of-aquaporin-4-immunoglobulin-g-in-longitudinally-extensive-transverse-myelitis-with-antiphospholipid-antibodies
#18
Hilda Guerra, Sean J Pittock, Kevin G Moder, James P Fryer, Avi Gadoth, Eoin P Flanagan
Antiphospholipid (aPL) antibodies have historically been postulated to cause a poorly understood inflammatory myelitis. Neuromyelitis optica spectrum disorder (NMOSD) causes an inflammatory longitudinally extensive transverse myelitis (LETM). In 2004, aquaporin-4 immunoglobulin G (AQP4-IgG) was first reported as a highly specific (>99%) serum diagnostic biomarker of NMOSD, distinguishing it from other disorders (eg, multiple sclerosis). We sought to assess the frequency of AQP4-IgG (and thus NMOSD diagnosis) in LETM with aPL antibodies...
April 11, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29653272/evaluation-of-microsurgery-for-managing-giant-or-complex-cerebral-aneurysms-a-retrospective-study
#19
Nakao Ota, Hidetoshi Matsukawa, Kosumo Noda, Hirotaka Sato, Yuto Hatano, Atsumu Hashimoto, Takanori Miyazaki, Tomomasa Kondo, Yu Kinoshita, Norihiro Saito, Hiroyasu Kamiyama, Sadahisa Tokuda, Kyousuke Kamada, Rokuya Tanikawa
OBJECTS: Surgical or endovascular treatment for giant or complex aneurysms is challenging. To evaluate clinical outcomes and factors affecting the prognosis of giant or complex aneurysms, and to better establish the role of microsurgery in the management strategy. METHODS: One hundred fifty-nine patients with surgically treated complex aneurysms were included. Thirty-two (20.1%) patients had giant aneurysms (≥25 mm); 57 (35.8%) had large aneurysms (≥15 mm). Poor outcome was defined as modified Rankin scale scores 3-6...
April 10, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29653270/decompressive-craniotomy-for-malignant-middle-cerebral-artery-infarction-optimal-timing-and-literature-review
#20
Ahmed Elsawaf, Ayman Galhom
OBJECT: To compare the results of early or delayed decompressive craniotomy (DC) for cases of malignant middle cerebral artery (MCA) infarction. STUDY DESIGN: Prospective comparative study METHODS: Prospective randomized study on consecutive series of a 46 patients with malignant MCA territory infarction. Patients were divided randomly into two groups: Group I; 27 patients who were followed till obvious deterioration of conscious level happened, Group II; 19 patients who were operated prophylactically in 6 hours of presentation even with no clear deterioration of conscious level or radiology's findings...
April 10, 2018: World Neurosurgery
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