keyword
MENU ▼
Read by QxMD icon Read
search

electroshock

keyword
https://www.readbyqxmd.com/read/29782051/the-novel-sodium-channel-modulator-gs-458967-gs967-is-an-effective-treatment-in-a-mouse-model-of-scn8a-encephalopathy
#1
Erin M Baker, Christopher H Thompson, Nicole A Hawkins, Jacy L Wagnon, Eric R Wengert, Manoj K Patel, Alfred L George, Miriam H Meisler, Jennifer A Kearney
OBJECTIVE: De novo mutations of SCN8A, encoding the voltage-gated sodium channel NaV 1.6, have been associated with a severe infant onset epileptic encephalopathy. Individuals with SCN8A encephalopathy have a mean age of seizure onset of 4-5 months, with multiple seizure types that are often refractory to treatment with available drugs. Anecdotal reports suggest that high-dose phenytoin is effective for some patients, but there are associated adverse effects and potential for toxicity...
May 21, 2018: Epilepsia
https://www.readbyqxmd.com/read/29780017/metazoan-parasite-faunas-of-three-gobiid-species-actinopterygii-gobiidae-inhabiting-the-lower-k%C3%A4-z%C3%A4-l%C3%A4-rmak-delta-in-samsun-a-comparative-study
#2
Arzu Güven, Türkay Öztürk
OBJECTIVE: The aim of the present study was to investigate and compare metazoan parasite faunas of three gobiid fishes, Neogobius fluviatilis, Proterorhinus marmoratus, and Pomatoschistus marmoratus, inhabiting the Lower Kızılırmak Delta. METHODS: Fish specimens were caught using fishing nets and electroshock device. The fishes were transferred to the laboratory and examined under a dissecting microscope for metazoan parasites using conventional methods. The isolated parasites were fixed with 70% ethyl alcohol...
March 2018: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/29778948/bioisosteres-of-ethyl-8-ethynyl-6-pyridin-2-yl-4h-benzo-f-imidazo-1-5-a-1-4-diazepine-3-carboxylate-hz-166-as-novel-alpha-2-3-selective-potentiators-of-gaba-a-receptors-improved-bioavailability-enhances-anticonvulsant-efficacy
#3
J M Witkin, J L Smith, X Ping, S D Gleason, M M Poe, G Li, X Jin, J Hobbs, J M Schkeryantz, J S McDermott, A I Alatorre, J N Siemian, J W Cramer, D C Airey, K R Methuku, V V N P B Tiruveedhula, T M Jones, J Crawford, M J Krambis, J L Fisher, J M Cook, R Cerne
HZ-166 has previously been characterized as an α2,3-selective GABAA receptor modulator with anticonvulsant, anxiolytic, and anti-nociceptive properties but reduced motor effects. We discovered a series of ester bioisosteres with reduced metabolic liabilities, leading to improved efficacy as anxiolytic-like compounds in rats. In the present study, we evaluated the anticonvulsant effects KRM-II-81 across several rodent models. In some models we also evaluated key structural analogs. KRM-II-81 suppressed hyper-excitation in a network of cultured cortical neurons without affecting the basal neuronal activity...
May 3, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29766822/2-5-disubstituted-phthalimides-design-synthesis-and-anticonvulsant-activity-in-scptz-and-mes-models
#4
Atefeh Saadabadi, Babak Kohen, Maryam Irandoust, Hamed Shafaroudi, Tara Mohammadpour, Mahdi Rezayat, Asghar Davood
In this study, fifteenth new 2,5-disubstituted analgouges of phthalimide were designed and synthesized using the appropriate synthetic route to evaluate anticonvulsant activity against the maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) compare to phenytoin as a positive control. The structures of the synthesized compounds were confirmed by FT-IR, H-NMR, C-NMR and MASS spectroscopy. All the tested compounds were found to be effective in the PTZ model at the dose of 60 mg/kg and most of the compounds showed protection against MES test indicative of their ability to inhibit the seizure spread at the all dose ranges...
May 15, 2018: Current Computer-aided Drug Design
https://www.readbyqxmd.com/read/29757029/electroshock-%C3%A2
#5
Ugo Cerletti, Lucio Bini
No abstract text is available yet for this article.
April 2018: International Review of Psychiatry
https://www.readbyqxmd.com/read/29750337/lamotrigine-resistant-corneal-kindled-mice-a-model-of-pharmacoresistant-partial-epilepsy-for-moderate-throughput-drug-discovery
#6
Zachery Koneval, Kevin M Knox, H Steve White, Melissa Barker-Haliski
OBJECTIVE: Despite numerous treatments for epilepsy, over 30% of patients remain resistant to available antiseizure drugs (ASDs). Thus, there is a strong need for more effective ASDs for these individuals. Early ASD discovery has historically relied on acute in vivo seizure models (maximal electroshock, subcutaneous pentylenetetrazol, 6 Hz), which lack the pathophysiology that defines chronic epilepsy. Etiologically relevant rodent models of pharmacoresistant epilepsy exist (eg, phenytoin (PHT)- and lamotrigine (LTG)-resistant amygdala-kindled rat and focal kainic acid mouse), but these models are resource- and labor-intensive and thus unsuitable for frontline ASD discovery...
May 11, 2018: Epilepsia
https://www.readbyqxmd.com/read/29741993/of-mice-men-and-trolleys-hypothetical-judgment-versus-real-life-behavior-in-trolley-style-moral-dilemmas
#7
Dries H Bostyn, Sybren Sevenhant, Arne Roets
Scholars have been using hypothetical dilemmas to investigate moral decision making for decades. However, whether people's responses to these dilemmas truly reflect the decisions they would make in real life is unclear. In the current study, participants had to make the real-life decision to administer an electroshock (that they did not know was bogus) to a single mouse or allow five other mice to receive the shock. Our results indicate that responses to hypothetical dilemmas are not predictive of real-life dilemma behavior, but they are predictive of affective and cognitive aspects of the real-life decision...
May 1, 2018: Psychological Science
https://www.readbyqxmd.com/read/29729290/anticonvulsant-evaluation-of-novel-non-imidazole-histamine-h-3-r-antagonists-in-different-convulsion-models-in-rats
#8
Alaa Alachkar, Gniewomir Latacz, Agata Siwek, Annamaria Lubelska, Ewelina Honkisz, Anna Gryboś, Dorota Łażewska, Jadwiga Handzlik, Holger Stark, Katarzyna Kiec-Kononowicz, Bassem Sadek
Novel non-imidazole histamine H3 receptor (H3R) antagonists (2-8) were developed and assessed for in-vitro antagonist binding affinities at the human histamine H1-H4R. These novel H3R antagonists (2-8) were examined in-vivo for anticonvulsant effects in three different convulsion models in male adult rats. Compound 6 significantly and dose-dependently exhibited decreased duration of tonic hind limb extension (THLE) in the maximal electroshock (MES)- and fully protected animals against pentylenetetrazole (PTZ)-induced convulsion, following acute systemic administration (5, 10, and 20 mg/kg, i...
May 2, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29723785/synthesis-and-biological-activity-of-novel-tert-butyl-and-tert-pentylphenoxyalkyl-piperazine-derivatives-as-histamine-h-3-r-ligands
#9
Katarzyna Szczepańska, Tadeusz Karcz, Szczepan Mogilski, Agata Siwek, Kamil J Kuder, Gniewomir Latacz, Monika Kubacka, Stefanie Hagenow, Annamaria Lubelska, Agnieszka Olejarz, Magdalena Kotańska, Bassem Sadek, Holger Stark, Katarzyna Kieć-Kononowicz
As a continuation of our search for novel histamine H3 receptor ligands, a series of twenty four new tert-butyl and tert-pentyl phenoxyalkylamine derivatives (2-25) was synthesized. Compounds with three to four carbon atoms alkyl chain spacer were evaluated for their binding properties at human histamine H3 receptor (hH3 R). The highest affinities were observed for 4-pyridyl derivatives 4, 10, 16 and 22 (Ki  = 16.0-120 nM). As it has been shown in docking studies, those specific heteroaromatic 4-N piperazine substituents might interact with one of the key receptor interacting amino acids...
April 25, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29681486/novel-naphthyloxy-derivatives-potent-histamine-h-3-receptor-ligands-synthesis-and-pharmacological-evaluation
#10
Dorota Łażewska, Maria Kaleta, Stefanie Hagenow, Szczepan Mogilski, Gniewomir Latacz, Tadeusz Karcz, Annamaria Lubelska, Ewelina Honkisz, Jadwiga Handzlik, David Reiner, Grzegorz Satała, Barbara Filipek, Holger Stark, Katarzyna Kieć-Kononowicz
A series of 1- and 2-naphthyloxy derivatives were synthesized and evaluated for histamine H3 receptor affinity. Most compounds showed high affinities with Ki values below 100 nM. The most potent ligand, 1-(5-(naphthalen-1-yloxy)pentyl)azepane (11) displayed high affinity for the histamine H3 receptor with a Ki value of 21.9 nM. The antagonist behaviour of 11 was confirmed both in vitro in the cAMP assay (IC50  = 312 nM) and in vivo in the rat dipsogenia model (ED50  = 3.68 nM). Moreover, compound 11 showed positive effects on scopolamine induced-memory deficits in mice (at doses of 10 and 15 mg/kg) and an analgesic effect in the formalin test in mice with ED50  = 30...
April 11, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29653413/influence-of-propafenone-on-the-anticonvulsant-activity-of-various-novel-antiepileptic-drugs-in-the-mouse-maximal-electroshock-model
#11
Kinga K Borowicz-Reutt, Monika Popławska, Monika Banach, Dorota Wróblewska
BACKGROUND: The main mechanism of action of propafenone (antiarrhythmic drug) involves the inhibition of the fast inward sodium current during phase 0 of the action potential. Sodium channel-blocking activity is also characteristic for some antiepileptic drugs. Therefore, it could be assumed that propafenone may also affect seizures. In the present study, we evaluated the effect of propafenone on the protective effect of oxcarbazepine, lamotrigine, topiramate and pregabalin against the maximal electroshock-induced seizures in mice...
November 23, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29644555/a-mechanistic-approach-to-explore-the-neuroprotective-potential-of-zonisamide-in-seizures
#12
Baldeep Kumar, Bikash Medhi, Manish Modi, Biman Saikia, Savita Verma Attri, Ajay Patial
BACKGROUND: Epilepsy, a disease of the brain, is one of the most common serious neurological conditions. It is associated with a group of processes which alter energy metabolism, interrupt cellular ionic homeostasis, cause receptor dysfunction, activate inflammatory cascade, alter neurotransmitter uptake and result in neuronal damage. The increasing knowledge and understanding about the basis of neuronal changes in epilepsy lead to investigate the mechanistic pathway of neuroprotective agents in epilepsy...
April 11, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29616753/isobolographic-additivity-among-lacosamide-lamotrigine-and-phenobarbital-in-a-mouse-tonic-clonic-seizure-model
#13
Maria W Kondrat-Wróbel, Jarogniew J Łuszczki
BACKGROUND: Epilepsy is a serious neurological disease affecting about 1% of people worldwide (65 million). Seizures are controllable with antiepileptic drugs (AEDs) in about 70% of epilepsy patients, however, there remains about 30% of patients inadequately medicated with these AEDs, who need a satisfactory control of their seizure attacks. For these patients, one of the treatment options is administration of 2 or 3 AEDs in combination. OBJECTIVES: To determine the anticonvulsant effects of a combination of 3 selected AEDs (i...
March 28, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29593494/antiepileptogenic-effect-of-subchronic-palmitoylethanolamide-treatment-in-a-mouse-model-of-acute-epilepsy
#14
Julia M Post, Sebastian Loch, Raissa Lerner, Floortje Remmers, Ermelinda Lomazzo, Beat Lutz, Laura Bindila
Research on the antiepileptic effects of (endo-)cannabinoids has remarkably progressed in the years following the discovery of fundamental role of the endocannabinoid (eCB) system in controlling neural excitability. Moreover, an increasing number of well-documented cases of epilepsy patients exhibiting multi-drug resistance report beneficial effects of cannabis use. Pre-clinical and clinical research has increasingly focused on the antiepileptic effectiveness of exogenous administration of cannabinoids and/or pharmacologically induced increase of eCBs such as anandamide (also known as arachidonoylethanolamide [AEA])...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29589139/fish-community-structure-and-diet-responses-to-newbury-weirs-in-a-low-gradient-river
#15
Sophia M Bonjour, Heidi M Rantala, Micah G Bennett, Matt R Whiles
Restoration projects are often implemented to address specific issues in the environment. Consequences of a restoration project, if any are measured, typically focus on direct changes to the projects focus. However, changing habitat structure likely results in changes to the environment that affect the communities living there. Rock weirs have been used for channel stabilization in many midwestern rivers. Previous research in a southern Illinois river found that weirs benefitted aquatic macroinvertebrate and riparian bird communities by enhancing habitat heterogeneity and insect emergence production...
March 27, 2018: Environmental Management
https://www.readbyqxmd.com/read/29587394/synthesis-and-evaluation-of-the-anticonvulsant-activities-of-4-2-alkylthio-benzo-d-oxazol-5-yl-2-4-dihydro-3h-1-2-4-triazol-3-ones
#16
Ming-Xia Song, Zhen-Yuan Wang, Shi-Hui He, Sheng-Wang Yu, Shi-Long Chen, Dong-Fu Guo, Wen-Hao Zhao, Xian-Qing Deng
In this study, a novel series of 4-(2-(alkylthio)benzo[ d ]oxazol-5-yl)-2,4-dihydro-3 H -1,2,4-triazol-3-ones ( 4a - m ) was designed and synthesized. The anticonvulsant activities of these compounds were evaluated by using the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ) seizure models in mice. The neurotoxicity of these compounds was evaluated using the rotarod neurotoxicity test. The majority of compounds showed anti-MES activities at 100 or 300 mg/kg. Compound 4g was considered to be the most promising, based on its potency against MES- and PTZ-induced seizures with ED50 values of 23...
March 25, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29577292/consequences-of-electroshock-induced-narcosis-in-fish-muscle-from-mitochondria-to-swim-performance
#17
L Teulier, L Guillard, C Leon, C Romestaing, Y Voituron
Adult zebrafish Danio rerio were exposed to an electric shock of 3V and 1A for 5 s delivered by field backpack electrofishing gear, to induce a taxis followed by a narcosis. The effect of such electric shock was investigated on both the individual performances (swimming capacities and costs of transport) and at cellular and mitochondrial levels (oxygen consumption and oxidative balance). The observed survival rate was very high (96.8%) independent of swimming speed (up to 10 body length s-1 ). The results showed no effect of the treatment on the metabolism and cost of transport of the fish...
March 25, 2018: Journal of Fish Biology
https://www.readbyqxmd.com/read/29568187/anticonvulsant-and-antioxidant-effects-of-musa-sapientum-stem-extract-on-acute-and-chronic-experimental-models-of-epilepsy
#18
Aditya J Reddy, Ashok Kumar Dubey, Shailendra S Handu, Prashant Sharma, Pramod K Mediratta, Qazi Mushtaq Ahmed, Seema Jain
Background: Musa sapientum (banana) plant extract has been shown to possess antioxidant activity in previous studies. Neuronal injury resulting from oxidative stress is an important factor involved in pathogenesis of epilepsy. Objective: The present study aimed to evaluate the anticonvulsant activity of M. sapientum stem extract (MSSE) in acute and chronic experimental models in mice and its effects on various markers of oxidative stress in the brain of pentylenetetrazole (PTZ)-kindled animals...
January 2018: Pharmacognosy Research
https://www.readbyqxmd.com/read/29558036/comparison-of-the-anticonvulsant-potency-of-various-diuretic-drugs-in-the-maximal-electroshock-induced-seizure-threshold-test-in-mice
#19
Katarzyna Załuska, Maria W Kondrat-Wróbel, Jarogniew J Łuszczki
BACKGROUND: The coexistence of seizures and arterial hypertension requires an adequate and efficacious treatment involving both protection from seizures and reduction of high arterial blood pressure. Accumulating evidence indicates that some diuretic drugs (with a well-established position in the treatment of arterial hypertension) also possess anticonvulsant properties in various experimental models of epilepsy. OBJECTIVES: The aim of this study was to assess the anticonvulsant potency of 6 commonly used diuretic drugs (i...
March 20, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29547827/pharmacological-characterization-of-the-cannabinoid-receptor-2-agonist-%C3%AE-caryophyllene-on-seizure-models-in-mice
#20
Jana Tchekalarova, Keylla da Conceição Machado, Antonio Luiz Gomes Júnior, Ana Amélia de Carvalho Melo Cavalcante, Albena Momchilova, Rumyana Tzoneva
PURPOSE: Activation of CB1 receptors, produces anticonvulsant effect accompanied by memory disturbance both in animal seizure tests and in patients with epilepsy. Few reports considered the role of CB2 receptor on seizure susceptibility and cognitive functions. The aim of the present study was to explore the effect of a selective CB2 receptor agonist β-caryophyllene (BCP) in models of seizures and cognition in mice. METHODS: Dose-dependent effects of BCP was studied in maximal electroshock seizure (MES) test, subcutaneous pentylenetetrazole (scPTZ) test and Morris water maze test...
March 12, 2018: Seizure: the Journal of the British Epilepsy Association
keyword
keyword
45636
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"