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Infantile hemangioma

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https://www.readbyqxmd.com/read/28429969/advances-in-pharmacotherapeutic-management-of-common-skin-diseases-in-neonates-and-infants
#1
Annalisa Patrizi, Iria Neri, Giampaolo Ricci, Francesca Cipriani, Giulia Maria Ravaioli
neonatal and infantile skin diseases are frequently encountered in the clinical practice and represent worldwide a socioeconomic issue. They encompass a wide range of acquired or congenital conditions, including infections, vascular lesions and inflammatory diseases and can present with different degrees of severity, leading in some cases to dramatic complications. Areas covered: In this paper we report the most recent evidences on the management of some common skin diseases in neonates and infants. Hemangiomas, viral, fungal and bacterial infections, omphalitis, atopic and seborrhoeic dermatitis, napkin disease will be treated and discussed...
April 21, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28424095/safety-and-effectiveness-of-oral-propranolol-for-infantile-hemangiomas-started-before-5%C3%A2-weeks-and-after-5%C3%A2-months-of-age-an-italian-multicenter-experience
#2
Maya El Hachem, Francesco Gesualdo, Andrea Diociaiuti, Irene Berti, Nadia Vercellino, Valeria Boccaletti, Iria Neri, Giulio Porcedda, Antonella Greco, Claudia Carnevale, Teresa Oranges, Mario Cutrone, Pietro Dalmonte
BACKGROUND: Despite not being licensed for the treatment of infantile hemangiomas (IH) in infants younger than 5 weeks or older than 5 months, propranolol is often used in these age groups to prevent or to treat potentially severe complications. The objective of the present study was to review the experience of 8 Italian pediatric and dermatologic centers regarding propranolol treatment for IH started before 5 weeks or after 5 months of age. METHODS: We retrospectively reviewed the records of patients followed up for IH, on propranolol treatment started before 5 weeks or after 5 months of age, and collected information on sociodemographic data, treatment indications, IH involution, IH relapse, and treatment side effects...
April 19, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28423174/comparison-of-efficacy-and-safety-between-propranolol-and-steroid-for-infantile-hemangioma-a-randomized-clinical-trial
#3
Kyu Han Kim, Tae Hyun Choi, Yunhee Choi, Young Woon Park, Ki Yong Hong, Dong Young Kim, Yun Seon Choe, Hyunjung Lee, Jung-Eun Cheon, Jung-Bin Park, Kyung Duk Park, Hyoung Jin Kang, Hee Young Shin, Jae Hoon Jeong
Importance: There are limited data from randomized clinical trials comparing propranolol and steroid medication for treatment of infantile hemangioma (IH). Objective: To determine the efficacy and safety of propranolol compared with steroid as a first-line treatment for IH. Design, Setting, and Participants: This randomized clinical noninferiority trial tested the efficacy and safety of propranolol vs steroid treatment for IH at a single academic hospital...
April 19, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28421234/the-role-of-topical-timolol-in-the-treatment-of-infantile-heman-giomas-a-systematic-review-and-meta-analysis
#4
Maham Khan, Aaron Boyce, David Prieto-Merino, Åke Svensson, Emma Wedgeworth, Carsten Flohr
To date the efficacy and safety of topical timolol in the treatment of infantile hemangioma has not be reviewed and analysed systematically. We collated all published data on the efficacy and safety of topical timolol in the treatment of infantile hemangioma. A total of 31 studies with 691 patients were included. The fixed effects pooled estimate of the response rate defined as any improvement from baseline of infantile hemangioma after treatment with topical timolol was significant (RR = 8.96; 95% CI 5...
April 19, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28412265/one-stage-supramaximal-full-thickness-wedge-resection-of-vascular-lip-anomalies
#5
Dawn K De Castro, Zhi Yang Ng, Paul W Holzer, Milton Waner, Curtis L Cetrulo, Aaron Fay
PURPOSE: Vascular lip anomalies include infantile hemangiomas, venous malformations, and arteriovenous malformations. Surgical management can be complicated by alterations in horizontal length, vertical height, and lip thickness from the underlying pathology. Additional reconstructive challenges include preservation of oral continence, vermillion definition, and the sublabial sulcus. This report describes a technique of supramaximal single-stage full-thickness wedge resection of these lesions...
March 22, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28411779/prescribing-propranolol-for-infantile-hemangioma-assessment-of-dosing-errors
#6
Anastasia O Kurta, Daisy Dai, Eric S Armbrecht, Elaine C Siegfried
No abstract text is available yet for this article.
May 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28408631/asymmetric-meckel-cave-enlargement-a-potential-marker-of-phaces-syndrome
#7
J N Wright, V Wycoco
BACKGROUND AND PURPOSE: PHACES syndrome is a complex of morphologic abnormalities of unknown cause and includes posterior fossa abnormalities; head and neck infantile hemangiomas; arterial, cardiac, and eye anomalies; and sternal or abdominal wall defects. Accurate identification of the syndrome is important for optimal treatment. The purpose of this study was to investigate the incidence of asymmetric Meckel cave enlargement, a potential novel imaging marker, in a population of patients referred for evaluation of possible PHACES syndrome...
April 13, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28406866/successful-treatment-of-a-residual-thick-infantile-hemangioma-in-a-darker-phototype-pediatric-patient-using-the-755-nm-long-pulsed-alexandrite-laser
#8
Hao Feng, Arielle N B Kauvar
No abstract text is available yet for this article.
April 11, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28402073/infantile-hemangiomas-an-updated-review-on-risk-factors-pathogenesis-and-treatment
#9
REVIEW
Chelsey J Forbess Smith, Sheila Fallon Friedlander, Monica Guma, Arthur Kavanaugh, Christina D Chambers
Infantile hemangiomas (IHs) are the most common vascular tumors in infants, appearing in early infancy and ultimately regressing with time. Clinical presentation may vary, with a minority of lesions causing impairment of vital function (e.g., respiratory or visual obstruction), permanent scarring, and/or disfigurement. The pathogenesis of IH is complex and poorly understood. Risk factors implicated in their development include preterm birth and placental anomalies. IH presents a myriad of clinical challenges, including correct diagnosis and whether or not to pursue treatment...
April 12, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28393235/epigenetic-silencing-of-mir-130a-ameliorates-hemangioma-by-targeting-tissue-factor-pathway-inhibitor%C3%A2-2-through-fak-pi3k-rac1-mdm2-signaling
#10
Feng Gao, Fa-Gang Wang, Ren-Rong Liu, Feng Xue, Jian Zhang, Guang-Qi Xu, Jian-Hai Bi, Zhen Meng, Ran Huo
Hemangiomas are the most common vascular tumors that occur frequently in prematures and females. microRNA (miR)-130a is associated with the growth and invasion in many tumors, and its role in hemangiomas has not been addressed so far. The present study revealed that miR‑130a was overexpressed in infantile hemangioma tissues compared with matched tumor-adjacent tissues. The inhibitor of miR-130a restrained cell growth and induced cell apoptosis in vitro. miR‑130a inhibitor also induced a cell cycle arrest at G2/M phase...
May 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28387902/angiogenesis-characteristics-of-infantile-hemangioma-and-feasibility-observation-of-transplantation-model-of-human-hemangioma-on-mice
#11
Y Fu, Z-G Yang, L-Y Zhao
OBJECTIVE: To study pathogenic features of pediatric hemangiomas, we successfully established a model in mice, by transplanting human hemangioma tissues. MATERIALS AND METHODS: The hemangioma from the leg of a two-month-old infant was dissected and sliced into several pieces. During a careful surgical procedure, the hemangioma tissues were individually transplanted into skin incisions in anesthetized mice. The volume of the transplanted tumors was measured and the changes in shape recorded at 1 day, and at 1, 2, 3, 4, 5 and 6 months after the transplantation...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28382698/burden-of-infantile-hemangioma-on-family-an-international-observational-cross-sectional-study
#12
Christine Cazeau, Francine Blei, María Del Rosario Fátima Gonzáles Hermosa, Riccardo Cavalli, Olivia Boccara, Regina Fölster-Holst, Gilles Berdeaux, Alain Delarue, Jean-Jacques Voisard
BACKGROUND/OBJECTIVES: Infantile hemangioma (IH) is the most frequent benign tumor of infancy resulting from vascular proliferation. Data regarding the burden on families of children with IHs are limited. This study aimed to characterize IHs and provide a comprehensive evaluation of the burden of IHs on parents of children requiring systemic treatment in the United States and Europe. METHODS: This noninterventional cross-sectional study included infants with newly diagnosed IH requiring systemic treatment...
April 6, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28376078/the-expression-of-renin-angiotensin-aldosterone-axis-components-in-infantile-hemangioma-tissue-and-the-impact-of-propranolol-treatment
#13
James R Dornhoffer, Ting Wei, Haihong Zhang, Emily Miller, Mario Cleves, Gresham T Richter
BACKGROUND: Propranolol's mechanism of action for controlling infantile hemangioma (IH) remains unclear. We hypothesize that this non-selective beta antagonist downregulates Renin-Angiotensin-Aldosterone (RAA) axis components, preventing angiogenic substrate induction of IH. METHODS: IH tissue and serum were collected from children with propranolol-treated or untreated IHs during surgery. Patients' normal skin and serum from demographically matched children were used as controls...
April 4, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28370639/transcriptional-activation-of-hedgehog-pathway-components-in-aggressive-hemangioma
#14
Danielle S Wendling-Keim, Lynn Wanie, Rainer Grantzow, Roland Kappler
Infantile hemangioma is a vascular neoplasm and is one of the most common tumors diagnosed in young children. Although most hemangiomas are harmless and involute spontaneously, some show severe progression, leading to serious complications, such as high output cardiac failure, ulcerations, compression of the trachea or deprivation amblyopia, depending on their size and localization. However, the pathogenesis and cause of hemangioma are largely unknown to date. The goal of this study was to identify markers that could predict hemangiomas with aggressive growth and severe progression that would benefit from early intervention...
March 31, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28369943/spectral-doppler-ultrasound-for-predicting-long-term-response-to-topical-timolol-in-children-with-infantile-hemangioma
#15
Lili He, Guoying Huang
BACKGROUND: To assess the utility of color and spectral Doppler ultrasound at predicting infantile hemangioma (IH) response to timolol. METHODS: Eighty-three children (0-6 months old) with IH were treated with topical 0.5% timolol maleate twice daily for 6 months. They underwent color and spectral Doppler sonographic examinations at the first visit and 1 month after beginning timolol. Hemangioma volume, arterial diameter (AD), venous diameter (VD), resistance index (RI), pulsatility index (PI), peak arterial systolic velocity (PASV), maximum venous velocity, and mean venous velocity were measured...
March 31, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28365065/infantile-hemangiopericytoma-of-the-tongue-efficacy-of-ex-utero-intrapartum-treatment-procedure-and-combined-modality-therapy
#16
Takenori Ogawa, Ryo Ishii, Daiki Ozawa, Takeshi Rikiishi, Hajime Usubuchi, Mika Watanabe, Yoshimichi Imai, Kenichi Sato, Masatoshi Saito, Yoji Sasahara, Tadashi Matsuda, Shigeo Kure, Yukio Katori
Here we present an extremely rare case of giant infantile hemangiopericytoma (HPC) of the tongue diagnosed prenatally by fetal ultrasonography and MR imaging. Due to airway stenosis, the patient was delivered by the ex utero intrapartum treatment (EXIT) procedure at 36 weeks of pregnancy. Initial diagnosis was infantile hemangioma based on physical examination, diagnostic imaging and the high incidence of hemangioma. The tumor was resistant to conservative treatments. Due to severe tumor hemorrhage, the nutrient vessel was embolized by endovascular treatment on the 73th day after birth...
March 29, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28350124/downregulation-of-mir-382-by-propranolol-inhibits-the-progression-of-infantile-hemangioma-via-the-pten-mediated-akt-mtor-pathway
#17
Dongfan Li, Peng Li, Zhengtuan Guo, Huaijie Wang, Weikang Pan
Approximately 10% of infantile hemangiomas (IHs) are the most common vascular tumors affecting children and are characterized by rapid growth, and can have destructive, disfiguring and even life-threatening consequences. Currently, propranolol is considered to be a safe and effective treatment option for problematic proliferating IHs. Recent studies have also revealed that microRNAs (miRNAs or miRs) play important roles in the regulation of angiogenesis. In this study, XPTS‑1 cells were used as a hemangioma-derived endothelial cell line constructed in our laboratory...
January 20, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28329512/propranolol-for-infantile-hemangiomas-in-developing-countries
#18
Josette McMichael, Leslie P Lawley
BACKGROUND: Propranolol is the treatment of choicefor complicated infantile hemangiomas (IH). However,in some locations, propranolol has not yet becomestandard of care. To our knowledge, until 2014,propranolol had not been used in Afghanistan totreat IH. OBJECTIVES: To raise further awareness thatpropranolol is the treatment of choice for complicatedIH, suggest a propranolol induction, maintenance,and taper protocol, show an example of therapeuticsuccess in a resource-limited country, and discusspotential challenges...
March 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28303612/infant-skin-maturation-preliminary-outcomes-for-color-and-biomechanical-properties
#19
M O Visscher, S A Burkes, D M Adams, A M Hammill, R R Wickett
BACKGROUND: Newborn infant skin changes after birth but studies have focused on the epidermal barrier. Dermal properties are relevant for care, but literature on postnatal changes is sparse. We further characterized skin maturational changes in lightness, color and response to biomechanical stress. METHODS: Normal skin sites from subsets of participants in a trial on the progression and stage of infantile hemangiomas were retrospectively examined. Standardized photographs were analyzed as L*, a*, and b* images...
March 16, 2017: Skin Research and Technology
https://www.readbyqxmd.com/read/28303101/psoriasiform-diaper-rash-possibly-induced-by-oral-propranolol-in-an-18-month-old-girl-with-infantile-hemangioma
#20
Raphaëlle Baggio, Claire Le Treut, Laure Darrieux, Amélie Vareliette, Gilles Safa
Propranolol, a nonselective blocker of β-adrenergic receptors, has become the first-line treatment for complicated infantile hemangiomas. Therefore, its use in the pediatric population has expanded in recent years. In adults, β-blockers have been reported to be the most common causative agents for drug-induced psoriasis. In infants treated with propranolol for infantile hemangioma, the onset of psoriasiform diaper rash has not yet been reported. Here, to the best of our knowledge, we report the first case of psoriasiform diaper rash possibly induced by oral propranolol in an 18-month-old girl with no family history of psoriasis...
September 2016: Case Reports in Dermatology
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