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Infantile hemangioma

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https://www.readbyqxmd.com/read/27911476/nd-yag-and-pulsed-dye-laser-therapy-in-infantile-hemangiomas-a-retrospective-analysis-of-271-treated-hemangiomas-in-149-children
#1
F Hartmann, A Lockmann, L-L Grönemeyer, H A Haenssle, M Zutt, H von Fintel, I Kühnle, M P Schön, K-M Thoms
BACKGROUND: Infantile hemangiomas (IH) are common benign tumors in infancy. Most IH resolve spontaneously, but some require treatment due to ulceration, functional impairment or cosmetic disfiguration. While systemic propranolol is effective in many cases, laser therapy may be a safe topical alternative. OBJECTIVE: To assess the efficacy of combined Nd:YAG/pulsed dye laser (PDL) or PDL alone for therapy of IH. PATIENTS AND METHODS: 271 IH in 149 infants were treated with combined Nd:YAG/PDL or PDL alone...
December 2, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27910123/congenital-infantile-fibrosarcoma-mimicking-a-cutaneous-vascular-lesion-a-case-report-and-review-of-the-literature
#2
Tyler Enos, Gregory A Hosler, Naseem Uddin, Adnan Mir
Congenital infantile fibrosarcoma (CIFS) is a rare neoplasm of infancy that occurs most frequently in the extremities, and when presenting in the skin, may sometimes resemble infantile hemangiomas or other vascular lesions. Clinically, these tumors differ from hemangiomas in the time of onset, morphology, and growth pattern and must be evaluated histologically for definitive diagnosis. We describe an infant with a neoplasm involving the distal left forearm initially presumed to be a vascular lesion after evaluation by two separate ultrasound studies...
November 7, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27898622/review-of-the-treatment-of-periocular-infantile-hemangiomas-with-beta-blockers
#3
Heather M Tamez, Rachel Sobel
No abstract text is available yet for this article.
2017: International Ophthalmology Clinics
https://www.readbyqxmd.com/read/27895515/excellent-response-of-infantile-orbital-hemangioma-to-propranolol
#4
Fandresena A Sendrasoa, Irina M Ranaivo, Naina H Razanakoto, Malalaniaina Andrianarison, Lala S Ramarozatovo, F Rapelanoro Rabenja
Infantile hemangiomas are the most common vascular neoplasm that present in infancy, with more than half affecting the head and neck region. Periocularly, hemangiomas may be complicated by visual loss through induction of strabismal, deprivational, or anisometropic astigmatism. We report a case of a 5-year-old girl who presented with orbital hemangioma with potential risk of visual loss who had excellent response to propranolol.
2016: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/27873347/infantile-hemangioma-with-minimal-or-arrested-growth-further-observations-on-clinical-and-histopathologic-findings-of-this-unique-but-underrecognized-entity
#5
Ellen Hui Ma, Susan J Robertson, Chung W Chow, Philip S Bekhor
BACKGROUND: Infantile hemangioma (IH) with minimal or arrested growth (IH-MAG) is becoming increasingly recognized in the literature. It is important to be aware of their existence, because the correct diagnosis is essential for prognostication and treatment and, in the case of facial segmental lesions, the direction of further investigations if PHACE (posterior fossa abnormalities and other structural brain abnormalities; hemangioma(s) of the cervical facial region; arterial cerebrovascular anomalies; cardiac defects, aortic coarctation, and other aortic abnormalities; eye anomalies) syndrome or Sturge-Weber syndrome is suspected...
November 22, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27857521/global-chemical-reactivity-parameters-for-several-chiral-beta-blockers-from-the-density-functional-theory-viewpoint
#6
Mona Maria Talmaciu, Ede Bodoki, Radu Oprean
BACKGROUND AND AIM: Beta-adrenergic antagonists have been established as first line treatment in the medical management of hypertension, acute coronary syndrome and other cardiovascular diseases, as well as for the prevention of initial episodes of gastrointestinal bleeding in patients with cirrhosis and esophageal varices, glaucoma, and have recently become the main form of treatment of infantile hemangiomas. The aim of the present study is to calculate for 14 beta-blockers several quantum chemical descriptors in order to interpret various molecular properties such as electronic structure, conformation, reactivity, in the interest of determining how such descriptors could have an impact on our understanding of the experimental observations and describing various aspects of chemical binding of beta-blockers in terms of these descriptors...
2016: Clujul Medical (1957)
https://www.readbyqxmd.com/read/27813086/ultrasonography-as-an-objective-tool-for-assessment-of-infantile-hemangioma-treatment-with-propranolol
#7
Anita Rotter, Luciana Paula Samorano, Glaucia Helena de Oliveira Labinas, Juliana Gobbi Alvarenga, Maria Cecília Rivitti-Machado, Márcio Bouer, Paulo C C Santos, Daniel A M Silvestre, Zilda Najjar Prado de Oliveira
BACKGROUND: Infantile hemangiomas (IHs) are the most common benign vascular tumors of childhood. Propranolol is an effective drug in treating IH. A reliable and complementary instrument is necessary to evaluate IH response to propranolol in addition to clinical and photographic assessments. Ultrasonography is a simple and non-invasive technique that enables precise measurements of tumor size and contributes to objective follow-up. OBJECTIVE: To demonstrate the use of serial ultrasonography as an adjunctive tool for assessment of IH treatment with propranolol...
November 4, 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/27808405/can-topical-beta-blockers-reduce-the-size-of-superficial-infantile-hemangiomas-of-the-head-and-neck
#8
Randall A Bly, Jonathan Perkins, Sanjay R Parikh
No abstract text is available yet for this article.
November 3, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27786256/infantile-hemangioma-originates-from-a-dysregulated-but-not-fully-transformed-multipotent-stem-cell
#9
Shaghayegh Harbi, Rong Wang, Michael Gregory, Nicole Hanson, Keith Kobylarz, Kamilah Ryan, Yan Deng, Peter Lopez, Luis Chiriboga, Paolo Mignatti
Infantile hemangioma (IH) is the most common tumor of infancy. Its cellular origin and biological signals for uncontrolled growth are poorly understood, and specific pharmacological treatment is unavailable. To understand the process of hemangioma-genesis we characterized the progenitor hemangioma-derived stem cell (HemSC) and its lineage and non-lineage derivatives. For this purpose we performed a high-throughput (HT) phenotypic and gene expression analysis of HemSCs, and analyzed HemSC-derived tumorspheres...
October 27, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27769582/-orbito-palpebral-vascular-pathology
#10
F Heran Dreyfus, O Galatoire, P Koskas, F Lafitte, E Nau, O Bergès
Orbito-palpebral vascular pathology represents 10% of all the diseases of this area. The lesion may be discovered during a brain CT scan or MRI, or because it causes clinical symptoms such as orbital mass, visual or oculomotor alteration, pain, proptosis, or acute bleeding due to a complication of the lesion (hemorrhage, thrombosis). We present these lesions using an anatomical, clinical, imaging and therapeutic approach. We distinguish four different entities. Vascular tumors have common imaging characteristics (hypersignal on T2 sequence, contrast enhancement, abnormal vascularization well depicted with ultrasound and Doppler, and possible bleeding)...
October 18, 2016: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/27756073/cardiovascular-profile-of-propranolol-after-multiple-dosing-in-infantile-hemangioma
#11
Patrizia Salice, Mario Giovanni Bianchetti, Alessandra Giavarini, Erica Gondoni, Riccardo Cavalli, Anna Maria Colli, Federico Lombardi
Propranolol is becoming the treatment of choice for complicated infantile hemangioma. We report here data on peripheral blood flow, O2-saturation, electrocardiographic PR-interval, left ventricular function, blood pressure and heart rate that were assessed before and during treatment for ≥4 weeks with propranolol 2 mg/kg of body weight daily in 67 infants <12 months of age in normal sinus rhythm and with structurally normal hearts. Management with propranolol was well tolerated in all and did not modify peripheral blood flow, O2-saturation, electrocardiographic PR-interval and left ventricular fractional shortening or ejection fraction...
October 19, 2016: Pharmacology
https://www.readbyqxmd.com/read/27747797/therapeutic-effect-of-propranolol-in-mexican-patients-with-infantile-hemangioma
#12
Saul Castaneda, Esbeydy Garcia, Hermelinda De la Cruz, Oscar Ramirez, Samuel Melendez, Jose Sanchez-Palacio
BACKGROUND: Infantile hemangiomas are the most common childhood vascular tumors, occurring in 10 % of children aged less than 1 year. Propranolol, a β-adrenergic blocker mainly indicated for hypertension, has proven effective in treating these types of tumors. OBJECTIVE: To evaluate the efficacy and adverse effects of propranolol in Mexican pediatric patients diagnosed with infantile hemangioma, treated with an extemporaneously compounded solution of propranolol...
March 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27747719/propranolol-effectiveness-and-failure-in-infantile-cutaneous-hemangiomas
#13
Andrea Domenico Praticò, Filippo Caraci, Piero Pavone, Raffaele Falsaperla, Filippo Drago, Martino Ruggieri
Infantile hemangiomas (IHs) occur in early infancy and are considered to be one of the most frequent childhood tumors. Poor responsiveness to the treatment and complications are reported in about 10 % of patients. For years, the most common treatments for cutaneous and complicated IHs were corticosteroids, interferon-α, vincristine, laser therapy, or surgical intervention. More recently, treatment with propranolol has been reported with high success rates, both in the cutaneous and complicated form of IHs, and it is now considered to be the first-line treatment for IHs...
December 2015: Drug Saf Case Rep
https://www.readbyqxmd.com/read/27737446/expression-of-%C3%AE-adrenergic-receptor-subtypes-in-proliferative-involuted-and-propranolol-responsive-infantile-hemangiomas
#14
James D Phillips, Haihong Zhang, Ting Wei, Gresham T Richter
Importance: Propranolol hydrochloride has become the primary medical treatment for problematic infantile hemangioma; however, the expression of propranolol's target receptors during growth, involution, and treatment of hemangioma remains unclear. Objective: To measure and compare the expression of β1-, β2-, and β3-adrenergic receptors (ADBR1, ADBR2, and ADBR3, respectively) in proliferative (n = 10), involuted (n = 11), and propranolol-responsive (n = 12) hemangioma tissue...
October 13, 2016: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/27709553/long-noncoding-rna-expression-profile-of-infantile-hemangioma-identified-by-microarray-analysis
#15
Xiaowen Liu, Renrong Lv, Linfeng Zhang, Guangqi Xu, Jianhai Bi, Feng Gao, Jian Zhang, Feng Xue, Fagang Wang, Yiliang Wu, Cong Fu, Qiang Wang, Ran Huo
Infantile hemangioma (IH) is one of the most common vascular tumors of childhood. Long noncoding RNAs (lncRNAs) play a critical role in angiogenesis, but their involvement in hemangioma remains unknown. This study aimed to assess the expression profiles of lncRNAs in IH and adjacent normal tissue samples, exploring the biological functions of lncRNAs as well as their involvement in IH pathogenesis. The lncRNA expression profiles were determined by lncRNA microarrays. A total of 1259 and 857 lncRNAs were upregulated and downregulated in IH, respectively, at a fold change cutoff of 2...
October 5, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27699864/retrospective-study-of-nasal-infantile-hemangiomas-characteristics-complications-and-outcomes
#16
Maria S Kryatova, Barbara M Rainer, Jiawei Zhao, Vadim A Villarroel, Anna Yasmine Kirkorian, Anna L Grossberg, Katherine B Puttgen, Bernard A Cohen
BACKGROUND/OBJECTIVES: Nasal infantile hemangiomas (IHs) pose serious medical complications and psychosocial stress if tumor involution is incomplete or prolonged. The objective was to determine which IH characteristics are associated with complications and are predictive of outcome, assessed as the presence of IHs or residual skin changes upon kindergarten entry, to better manage these lesions and counsel families. METHODS: A retrospective chart review of all patients seen in the Division of Pediatric Dermatology at Johns Hopkins Medicine between 2001 and 2014 for nasal IHs (N = 89) was performed...
October 4, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27688361/safety-of-oral-propranolol-for-the-treatment-of-infantile-hemangioma-a-systematic-review
#17
Christine Léaute-Labrèze, Olivia Boccara, Caroline Degrugillier-Chopinet, Juliette Mazereeuw-Hautier, Sorilla Prey, Geneviève Lebbé, Stéphanie Gautier, Valérie Ortis, Martine Lafon, Agnès Montagne, Alain Delarue, Jean-Jacques Voisard
BACKGROUND AND OBJECTIVES: Given the widespread use of propranolol in infantile hemangioma (IH) it was considered essential to perform a systematic review of its safety. The objectives of this review were to evaluate the safety profile of oral propranolol in the treatment of IH. METHODS: We searched Embase and Medline databases (2007-July 2014) and unpublished data from the manufacturer of Hemangiol/Hemangeol (marketed pediatric formulation of oral propranolol; Pierre Fabre Dermatologie, Lavaur, France)...
September 29, 2016: Pediatrics
https://www.readbyqxmd.com/read/27686480/fine-clinical-differences-between-patients-with-multifocal-and-diffuse-hepatic-hemangiomas
#18
Kai Li, Zuopeng Wang, Yinhua Liu, Wei Yao, Yin Gong, Xianmin Xiao
BACKGROUND: It has been reported that multifocal and diffuse hepatic hemangiomas are true infantile hemangiomas for which a continuum probably exists. We determined the similarities and fine differences between the two types of hemangioma and identified the multifocal subgroup of type, which needs timely treatment. MATERIAL AND METHODS: Twenty-four patients (4 males and 20 females; age 114±142days) with multifocal or diffuse hepatic hemangiomas who were treated between January 2000 and June 2015 were studied...
September 16, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27660822/endothelial-and-circulating-c19mc-micrornas-are-biomarkers-of-infantile-hemangioma
#19
Graham M Strub, Andrew L Kirsh, Mark E Whipple, Winston P Kuo, Rachel B Keller, Raj P Kapur, Mark W Majesky, Jonathan A Perkins
Infantile hemangioma (IH) is the most common vascular tumor of infancy, and it uniquely regresses in response to oral propranolol. MicroRNAs (miRNAs) have emerged as key regulators of vascular development and are dysregulated in many disease processes, but the role of miRNAs in IH growth has not been investigated. We report expression of C19MC, a primate-specific megacluster of miRNAs expressed in placenta with rare expression in postnatal tissues, in glucose transporter 1-expressing (GLUT-1-expressing) IH endothelial cells and in the plasma of children with IH...
2016: JCI Insight
https://www.readbyqxmd.com/read/27617527/infantile-myofibroma-a-firm-round-plaque-in-an-infant
#20
Shinya Amano, Mark Halsey, Mariko Yasuda, Patrick O'Donnell, Courtney Csikesz
Infantile myofibroma is a rare fibromatous tumor that is variable in presentation and is frequently mistaken for hemangioma or rhabdomyosarcoma. We describe a 14-month-old boy who presented with multiple, enlarging, firm lesions on the shoulder. Biopsy revealed a proliferation of small spindle cells with myxoid and hyalinized stroma infiltrating into the superficial adipose tissue. We provide a brief review of the clinical presentation, histopathologic features, management, and recent advances in our understanding of this rare condition...
May 15, 2016: Dermatology Online Journal
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