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Infantile hemangioma

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https://www.readbyqxmd.com/read/28197761/the-pigment-epithelium-derived-factor-pedf-an-important-potential-therapeutic-agent-for-infantile-hemangioma
#1
Ming Li, Yanru Chen, Zhihui Guo, Yide Xie, Yakuan Zhou, Chenghong Jiang, Xiaosong Chen
In previous studies, the expression and the role of proangiogenic factors in infantile hemangiomas have been well studied. However, the role of angiogenic inhibitors has been revealed rarely. The expression of PEDF, as the strongest and safe endogenous inhibitor, is still unrecognized until the current study. In order to investigate the expression and significance of the pigment epithelium-derived factor (PEDF) in the proliferating and regressing phases of infantile hemangiomas, the expression of PEDF, VEGF, Ki-67, and CD34 protein in hemangioma tissues was examined with immunohistochemical polymer HRP method in 42 cases during the proliferative phase, 40 cases during the regressing phase, and 11 cases of non-involuting congenital hemangiomas (NICHs)...
February 14, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28196319/common-skin-conditions-in-children-congenital-melanocytic-nevi-and-infantile-hemangiomas
#2
Brian Z Rayala, Dean S Morrell
Congenital melanocytic nevi (CMN) are hamartomas present at birth that are composed of nevomelanocytes and thought to originate from faulty migration of precursor melanocytes in the neural crest. Classification is based on projected adult size of the lesion. CMN size correlates positively with risk of melanoma and neurocutaneous melanocytosis. Management requires a patient-centered approach that weighs the risks and benefits of and alternatives to complete removal. All children with large and giant CMN, regardless of surgical status, should be monitored closely and undergo periodic skin examination...
February 2017: FP Essentials
https://www.readbyqxmd.com/read/28194699/efficacy-and-safety-of-2-topical-propranolol-cream-for-the-treatment-of-proliferating-infantile-strawberry-hemangiomas
#3
Yuanyuan Wang, Xingcun Zhang, Yadong Yang, Junbo Zhang, Yunchuan Yang, Yuangang Lu
OBJECTIVE: To evaluate the efficacy and safety of 2% topical propranolol cream in the treatment of proliferating infantile strawberry hemangiomas. METHODS: A total of 40 infants were enrolled; 2% propranolol cream was applied three times daily. In the subsequent monthly visit, dynamic changes in tumor size, texture, and color were recorded. The adverse events (AEs) were observed. Treatment outcomes were scored on a four-point scale. All patients were followed up for 12 mo after treatment...
February 14, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28191659/lumbar-syndrome-a-case-manifesting-as-cutaneous-infantile-hemangiomas-of-the-lower-extremity-perineum-and-gluteal-region-and-a-review-of-published-work
#4
Xia Yu, Jia Zhang, Zhouwei Wu, Ming Liu, Ruhong Chen, Yan Gu, Ming Li, Zhirong Yao
We herein report a rare case of LUMBAR syndrome. A 1-month-old female infant presented with extensive segmental hemangiomas on the left lower extremity, left perineum and gluteal region with ulceration. Bilateral labia minoras were asymmetrical. Both legs were asymmetrical with left leg atrophy, and the intergluteal cleft was deviated. A dark red pustule and a sacrococcygeal dimple could be seen in the lumbosacral region. Lipomyelomeningocele, tethered cord and sacrum dysplasia were noted by magnetic resonance imaging...
February 13, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28191657/prospective-open-label-rater-blinded-and-self-controlled-pilot-study-of-the-treatment-of-proliferating-superficial-infantile-hemangiomas-with-0-5-topical-timolol-cream-versus-595-nm-pulsed-dye-laser
#5
Hanru Ying, Yun Zou, Wenxin Yu, Yajing Qiu, Gang Ma, Lei Chang, Yifei Gu, Dongze Lyu, Xiaoxi Lin
Topical timolol and 595-nm pulsed dye laser (PDL) are both widely used in the treatment of superficial infantile hemangiomas (IH). However, to date, there is no reliable study comparing the therapeutic outcomes between the two treatment options. We designed the present study to evaluate and compare the efficacy and safety of timolol cream and PDL in the treatment of superficial proliferating IH. Twenty-one patients with superficial IH were included in the study. Each lesion was divided into two regions; one part was treated with 0...
February 13, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28190620/propranolol-treatment-of-infantile-hemangioma-is-not-associated-with-psychological-problems-at-7%C3%A2-years-of-age
#6
Andre Vadimovich Moyakine, Saskia Spillekom-van Koulil, Catharina Joanna Maria van der Vleuten
BACKGROUND: Concern has been raised about the potential long-term effects of propranolol treatment for infantile hemangioma (IH). OBJECTIVES: We sought to assess psychologic (social, emotional, behavioral, and executive) functioning in children treated with propranolol for IH. METHODS: Twenty-seven patients with IH (6.1-7.6 years of age) treated with propranolol for ≥6 months during infancy, and without other developmental risk factors, were recruited...
February 9, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28168756/small-infantile-hemangioma-and-breast-hypoplasia
#7
C Velter, C Gronier, D Lipsker
Large and/or segmental infantile hemangiomas (IH) are sometimes associated with other localized and/or more widespread malformations such as those occurring in the PHACES (1). Breast hypoplasia occurring after IH has been barely reported (2). We report the case of a small IH of the breast, associated with a homolateral breast hypoplasia and we raise the question of a potential link between the 2 findings. This article is protected by copyright. All rights reserved.
February 6, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28152134/the-tissue-expander-effect-in-early-surgical-management-of-select-focal-infantile-hemangiomas
#8
Tara E Brennan, Milton Waner, Teresa M O
Importance: The current standard of treatment for infantile hemangiomas (IHs) involves initial observation for regression throughout infancy and childhood, with or without medical management with β-blocker medications. Approximately 50% of the lesions respond almost completely to this regimen. However, the remaining 50% of the lesions, especially established focal IHs of the lip, nose, eyelids, forehead, cheek, and scalp, do not regress completely with this regimen or do so leaving a deformity; among these lesions, early surgical management may result in a superior aesthetic and functional outcome...
February 2, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28144385/scalloping-characteristics-in-a-patient-with-extra-cranial-hemangioma
#9
Amit Agrawal, Ranjan K Jena, Umamaheswara Reddy
Infantile hemangiomas are the most common benign tumors of infancy and childhood with a reported incidence of 4% to 10% in infants. We report of a 9 year-old male child with a history of progressively increasing swelling over the right eyebrow region. The lesion was present since childhood; however, it increased in in size over the previous 3-4 months. The CT scan showed scalloping over the right supra-orbital ridge with an intact bone. The child underwent total excision of the lesion. A characteristic scalloping seen on imaging (depression in the outer or inner table of the skull) can help differentiate lesions of extracranial and intracranial origins...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28141640/successful-treatment-of-infantile-hemangiomas-with-propranolol-in-low-birth-weight-infants
#10
Makiko Kado, Azusa Shimizu, Takashi Matsumura, Mariko Mochizuki, Hiroshi Mizuno, Ayato Hayashi
BACKGROUND: Infantile hemangioma (IH) is a benign neoplasm that causes scarring and cosmetic problems after spontaneous regression. Therefore, aggressive treatments such as laser irradiation and corticosteroid have been used; however, recently, the effect of propranolol has been widely noticed. In this study, the authors applied propranolol to low-birth-weight infants with IHs and evaluated its effect. METHODS: Four low-birth-weight infants having IH were selected, with birth weights ranging from 582 to 814 g (average 703 g)...
January 30, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28112362/downregulation-of-mir-382-by-propranolol-inhibits-the-progression-of-infantile-hemangioma-via-the-pten-mediated-akt-mtor-pathway
#11
Dongfan Li, Peng Li, Zhengtuan Guo, Huaijie Wang, Weikang Pan
Approximately 10% of infantile hemangiomas (IHs) are the most common vascular tumors affecting children and are characterized by rapid growth, and can have destructive, disfiguring and even life-threatening consequences. Currently, propranolol is considered to be a safe and effective treatment option for problematic proliferating IHs. Recent studies have also revealed that microRNAs (miRNAs or miRs) play important roles in the regulation of angiogenesis. In this study, XPTS‑1 cells were used as a hemangioma-derived endothelial cell line constructed in our laboratory...
January 20, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28111788/benign-vascular-lesions-of-the-lips-diagnostic-approach
#12
Priscila Lie Tobouti, Isabel Olegário, Suzana Cantanhede Orsini Machado de Sousa
BACKGROUND: Although not rare, vascular lesions occurring in the lips sometimes poses a difficult in properly diagnosing and handling them. In the present study vascular lesions occurring in the lips were retrieved from an Oral Pathology Service. METHODS: Among 5,600 biopsies, 131 cases were found. The following diagnoses were attributed: caliber-persistent artery, infantile hemangioma, vascular malformation, venous lake, thrombus, papillary endothelial hyperplasia, and pyogenic granuloma...
January 23, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28109716/primary-mesenchymal-liver-tumors-of-childhood
#13
Omer Saeed, Romil Saxena
Primary mesenchymal tumors of the liver represent a significant proportion of liver tumors among neonates, infants and young children. They may be discovered incidentally or present with an alarmingly large, rapidly growing abdominal mass. One third of pediatric liver tumors are benign with hemangioma and mesenchymal hamartoma being the commonest in that order. Infantile hemangioendothelioma and mesenchymal hamartoma represent the commonest liver tumors among neonates and infants. Mesenchymal hamartoma may even present in utero...
December 23, 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28104640/arterial-spin-labeling-to-discriminate-pediatric-cervicofacial-soft-tissue-vascular-anomalies
#14
G Boulouis, V Dangouloff-Ros, O Boccara, N Garabedian, V Soupre, A Picard, V Couloigner, N Boddaert, O Naggara, F Brunelle
BACKGROUND AND PURPOSE: Differentiating major subtypes of cervicofacial vascular lesions is crucial for appropriate management. The aim of our study was to evaluate the performance of an MR imaging arterial spin-labeling perfusion sequence in discriminating pediatric cervicofacial soft-tissue vascular anomalies. MATERIALS AND METHODS: We conducted a retrospective analysis of data from a prospectively maintained registry including pediatric patients at a tertiary pediatric center between January 2012 and January 2014...
January 19, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28074521/assessment-of-the-effectiveness-of-topical-propranolol-4-gel-for-infantile-hemangiomas
#15
Jacob Mashiah, Ana Kutz, Smail Hadj Rabia, Efrat Bar Ilan, Ilan Goldberg, Eli Sprecher, Avikam Harel
BACKGROUND: Infantile hemangiomas (IHs) are the most common vascular tumors in children. Because of their benign character and natural involution, the vast majority of IHs do not require any treatment. In the past few years, topical beta blockers have been reported to be an effective treatment of superficial IHs. OBJECTIVE: We sought to evaluate the clinical effectiveness and safety profile of topical propranolol 4% gel for the treatment of IHs. METHODS: A retrospective study of all cases of IHs treated with topical propranolol 4% gel between 2013 and 2015 was performed...
February 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28064266/infantile-intraosseous-maxillary-hemangioma
#16
Divya Gupta, Ishwar Singh, Kavita Goyal, Parul Sobti
BACKGROUND: Primary osseous hemangiomas of the facial skeleton mimic malignancy. Their location in maxillary sinus, especially in infants is extremely rare. CASE CHARACTERISTICS: 1- month-old full term boy with maxillary swelling. OBSERVATIONS: Biopsy from oral route revealed hemangioma showing vascular channels lined by endothelial cells. Patient improved on oral steroids. MESSAGE: Hemangiomas should be considered as one of the differential diagnosis of unilateral maxillary swelling in infants...
December 15, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/28056491/propranolol-as-first-line-treatment-for-life-threatening-diffuse-infantile-hepatic-hemangioma-a-case-report
#17
Giulia Varrasso, Amalia Schiavetti, Silvia Lanciotti, Maria Sapio, Eva Ferrara, Alessandra De Grazia, And Anna Clerico
No abstract text is available yet for this article.
January 5, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28043186/oral-propranolol-for-infantile-hemangiomas-a-prospective-study-on-the-role-of-48-hour-holter-monitoring-in-additional-safety-assessment
#18
Jelena Petrovic, Branislav Trifunovic, Goran Vukomanovic, Mirko Topalovic, Goran Trajkovic, Vojislav Parezanović
PURPOSE: Oral propranolol has been recently approved for infantile hemangiomas (IHs), but potential side effects stay a challenge. We sought to make an additional assessment on oral propranolol safety for this indication. MATERIALS AND METHODS: Prospective study included 108 infants consecutively treated for IHs at the University Children's Hospital Tirsova, Belgrade from January 2010 to December 2013. Propranolol was administered orally at a daily dose of 0.5 mg/kg and doubled every 48 hours in the absence of side effects until reaching the maximum dose of 2 mg/kg daily...
January 11, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28017308/respiratory-distress-in-a-3-month-old-infant-with-a-mass-obstructing-the-right-main-stem-bronchus-an-unusual-localization-of-infantile-hemangioma
#19
Oliviero Sacco, Andrea Moscatelli, Paolo Nozza, Giovanni A Rossi
No abstract text is available yet for this article.
December 23, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27981617/utility-of-the-hemangioma-severity-scale-as-a-triage-tool-and-predictor-of-need-for-treatment
#20
Jamie L Mull, Sarah L Chamlin, Jin-Shei Lai, Jennifer L Beaumont, David Cella, Elizabeth A Rancour, Eulalia Baselga, Anita N Haggstrom
BACKGROUND/OBJECTIVES: Infantile hemangiomas (IHs) are commonly encountered in primary care and most often remain asymptomatic, resolving without sequelae. Certain characteristics are associated with a greater risk of complications, associated anomalies, and disfigurement. The heterogeneous presentation poses a clinical challenge for physicians in determining the need for treatment and subspecialty referral. This study aims to evaluate the utility of the previously published Hemangioma Severity Scale (HSS) to predict the need for treatment...
December 16, 2016: Pediatric Dermatology
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