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Basal cell carcinoma, Squamous cell carcinoma

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https://www.readbyqxmd.com/read/28106103/sox2-and-rb1-in-esophageal-small-cell-carcinoma-their-possible-involvement-in-pathogenesis
#1
Hirotaka Ishida, Atsuko Kasajima, Takashi Kamei, Tsuyoshi Miura, Naomi Oka, Samaneh Yazdani, Yohei Ozawa, Fumiyoshi Fujishima, Akira Sakurada, Yasuhiro Nakamura, Yoichi Tanaka, Masafumi Kurosumi, Yuichi Ishikawa, Yoshinori Okada, Noriaki Ohuchi, Hironobu Sasano
Clinicopathological features and pathogenesis of esophageal small-cell carcinoma remain unclear. We hypothesized common cellular origin and pathogenesis in small-cell carcinoma of esophagus and lung associated with SOX2 overexpression and loss of Rb1. Expression of squamous-basal markers (CK5/6 and p40), glandular markers (CK18 and CEA), SOX2, and Rb1 were evaluated in 15 esophageal small-cell carcinomas, 46 poorly differentiated squamous cell carcinomas, and 88 small-cell lung carcinoma, as well as 16 embryonic esophagus...
January 20, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28089000/incidence-ratio-of-basal-cell-carcinoma-to-squamous-cell-carcinoma-equalizes-with-age
#2
Harvind S Chahal, Kerri E Rieger, Kavita Y Sarin
No abstract text is available yet for this article.
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28087048/-characteristics-and-risk-factors-for-recurrence-of-cutaneous-squamous-cell-carcinoma-with-conventional-surgery-and-surgery-with-delayed-intraoperative-margin-assessment
#3
Judith Domínguez-Cherit, Georgina Rodríguez-Gutiérrez, Verónica Narváez Rosales, Sonia Toussaint Caire, Verónica Fonte Avalos
BACKGROUND: Non-melanoma skin cancer includes basal cell carcinoma and squamous cell carcinoma (SCC). Basal cell carcinoma is the most common and least aggressive but in a low percentage of cases, despite appropriate wide surgical margins, it can be aggressive, producing local invasion, recurrences and distance metastasis. SCC has a more aggressive behaviour invading first the skin, the lymph nodes and less frequently produces distance metastasis OBJECTIVE: To identify the characteristics of recurrent SCC and frequency of new SCC after conventional surgical and primary closure or closure delayed until a histological reporting of tumour-free surgical margins, in order to achieve a better surgical option, in our Mexican population...
January 10, 2017: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28067922/-reconstructieve-facial-surgery-in-facial-defects-after-the-surgical-removal-of-malignant-skin-tumours
#4
S Bolouri, F Bierenbroodspot, J Jansma
Because of the enormous and continuing increase in cases of skin cancer in the Netherlands, dentists will increasingly see patients with skin cancer. The most common malignant skin cancers are basal cell carcinoma, squamous cell carcinoma and malignant melanoma. With resection of a skin tumour, the oncological principles should be applied. For the closure of the resulting defect, a choice for the individual patient is made out of numerous techniques. Facial reconstructive surgery aims to restore the face in form and function and to maintain the patient's quality of life...
January 2017: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/28063168/phytochemicals-for-the-prevention-of-photocarcinogenesis
#5
Mary Katherine Montes de Oca, Ross L Pearlman, Sarah F McClees, Rebecca Strickland, Farrukh Afaq
Ultraviolet (UV) exposure has an array of damaging effects and is the main cause of skin cancer in humans. Non-melanoma skin cancer (NMSC), including basal cell carcinoma and squamous cell carcinoma, is the most common type of cancer. Incidence of NMSC has increased due to greater UV radiation, increased life expectancy, and other changes in lifestyle; the annual cost of skin cancer treatment in the United States has increased concurrently to around eight billion dollars. Because of these trends, novel approaches to skin cancer prevention have become an important area of research to decrease skin cancer morbidity and defray the costs associated with treatment...
January 7, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28061538/palliative-radiotherapy-for-skin-malignancies
#6
Winston Vuong, Jessica Lin, Randy L Wei
Palliative radiotherapy (PRT) improves patient quality of life (QoL) through alleviating cancer-associated symptoms such as pain, bleeding, and ulceration. Palliative management of patients with skin malignancies requires consideration of cosmetic and psychosocial outcomes as QoL measures. In this review, we highlight the current literature and advances in the use of PRT for patients with the three most commonly encountered forms of skin malignancies: basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma...
December 19, 2016: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/28058108/basosquamous-carcinoma-appearance-and-reality
#7
Rakesh L Anand, Damian Collins, Anna Chapman
Basosquamous carcinoma (BsC) is a controversial entity and both a diagnostic and therapeutic challenge. BsC has mixed histopathological characteristics of both basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). BCC and SCC display characteristic histopathology and behaviour; on the other hand, BsC is a rare tumour, which has variable morphology and displays less predictable behaviour. An early diagnosis of BsC is important due to the particularly aggressive nature of the tumour, the increased likelihood of recurrence and the potential for metastasis...
January 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/28052685/occurrence-of-malignancies-after-kidney-transplantation-in-adults-slovak-multicenter-experience
#8
Z Zilinska, M Sersenova, M Chrastina, J Breza Sr, L Bena, T Baltesova, A Jurcina, R Roland, E Lackova, M Cellar, L Laca, I Dedinska
Malignancies are one of the three major causes of renal recipient´s death with a functioning graft after cardiovascular diseases and infections. Among the variety of risk factors, including conventional and specific to transplant recipients, the duration of immunosuppressive therapy, the intensity of therapy, and the type of immunosuppressive agent all have an impact on development of post-transplant malignancy. The aim of our retrospective study was to document the incidence, the type of malignancies, the patient/graft survival in the group of kidney transplant recipients in Slovak Republic, and to identify the factors which influenced the outcome...
January 5, 2017: Neoplasma
https://www.readbyqxmd.com/read/28048327/su-f-p-58-squamous-cell-and-basal-cell-carcinoma-of-the-skin-treated-with-a-freiburg-flap-applicator
#9
K Dou, B Li, M Jacobs, B Laser
PURPOSE: To treat squamous cell and basal cell carcinoma of the skin with the Freiburg flap applicator using a high dose rate modality of an Elekta Flexitron or MicroSelectron for radiation delivery by compensating the dose deviation resulting from the incomplete scatter environment. METHODS: Patients were selected to have lesions greater than or equal to 2cm. A mask might be needed depending on special locations. The lesions on the eyelid and face presented in this research were, however, treated without a mask...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045814/recalcitrant-invasive-skin-cancer-of-the-scalp-combined-extirpation-and-microsurgical-reconstruction-without-cranioplasty
#10
Gerald J Cho, Frederick Wang, Steven M Garcia, Jennifer Viner, William Y Hoffman, Michael W McDermott, Jason H Pomerantz
BACKGROUND: Recurrent invasive skin cancer of the scalp and calvarium is a difficult problem for which universally accepted treatment protocols have not been established. The authors present their 10-year experience with treatment of this specific subset of scalp reconstruction patients and present a successful treatment algorithm that is well suited to this patient population. METHODS: The authors retrospectively reviewed all patients of microsurgical scalp reconstruction performed from 2005 to 2015 that involved invasive cutaneous malignancies of the scalp and calvarium...
December 30, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28030842/loss-of-runx3-expression-inhibits-bone-invasion-of-oral-squamous-cell-carcinoma
#11
Junhee Park, Hyun-Jeong Kim, Ki Rim Kim, Sun Kyoung Lee, Hyungkeun Kim, Kwang-Kyun Park, Won-Yoon Chung
High recurrence and lower survival rates in patients with oral squamous cell carcinoma (OSCC) are associated with its bone invasion. We identified the oncogenic role of RUNX3 during bone invasion by OSCC. Tumor growth and the generation of osteolytic lesions were significantly inhibited in mice that were subcutaneously inoculated with RUNX3-knockdown human OSCC cells. RUNX3 knockdown enhanced TGF-β-induced growth arrest and inhibited OSCC cell migration and invasion in the absence or presence of transforming growth factor-β (TGF-β), a major growth factor abundant in the bone microenvironment...
December 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/28030717/pathologic-evaluation-of-skin-tumors-with-ex-vivo-dermoscopy-with-derm-dotting
#12
Marc Haspeslagh, Isabelle Hoorens, Nele Degryse, Ine De Wispelaere, Annemarie Degroote, Sarah Van Belle, Jan Verboven, Katrien Vossaert, Fabio Facchetti, Jo Van Dorpe, Sofie De Schepper, Lieve Brochez
Importance: Ex vivo dermoscopy (EVD) with derm dotting (DD) improves clinicopathologic correlation and the quality of diagnosis in skin tumors. Objective: To compare the diagnostic performance of the standard method of skin biopsy processing with the practice of EVD with DD. Design, Setting, and Participants: This retrospective study compares the diagnostic performance in 6526 skin biopsy specimens examined from 2008 to 2010 with a standard method of processing with 8584 biopsy specimens examined in 2015 with EVD and DD...
December 28, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/28029677/an-interesting-case-of-basal-cell-carcinoma-with-raynaud-s-phenomenon-following-chronic-arsenic-exposure
#13
S Gulshan, M J Rahman, R Sarkar, S Ghosh, R Hazra
Arsenic is commonly known to be associated with squamous cell carcinoma. Among the lesser known associations is basal cell carcinoma and even rarer is its effect on blood vessels causing peripheral vascular disease. Here we present a case of a 55 yr old man with ulceroproliferative lesions on scalp and forehead along with several hyperpigmented patches on trunk and extremities. He had symptoms suggestive of Raynaud's phenomenon that eventually led to digital gangrene. FNAC was done which was suggestive of basal cell carcinoma...
October 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/28028856/british-association-of-dermatologists-national-audit-on-nonmelanoma-skin-cancer-excision-2014
#14
D J Keith, D A R de Berker, A P Bray, S T Cheung, A Brain, M F Mohd Mustapa
BACKGROUND: Diagnosis and management of nonmelanoma skin cancer (NMSC) represents a large part of the dermatology workload, and complete excision is a required surgical standard for treatment. AIM: To conduct an audit of the surgical practice for the treatment of NMSC by dermatologists in the UK. METHODS: Data on 10 consecutive nonmicrographic excisions of nonmelanoma skin cancer by UK dermatologists. Data collected included site, preoperative diagnosis, histological diagnosis, proximity to previous scars, and histological deep and peripheral margins...
January 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28027254/evidence-based-medicine-cutaneous-facial-malignancies-nonmelanoma-skin-cancer
#15
Karen L Connolly, Kishwer S Nehal, Joseph J Disa
LEARNING OBJECTIVES: After studying this article, the participant should be able to: 1. Identify clinical features of nonmelanoma skin cancer; 2. Distinguish low-risk versus high-risk basal cell carcinoma and squamous cell carcinoma; 3. Define appropriate management based on current guidelines for various types of basal cell and squamous cell carcinoma. SUMMARY: Skin malignancies are the most prevalent cancers, and plastic surgeons are often the primary physicians engaged in diagnosis and management of these lesions...
January 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28027201/incidence-and-clinical-features-of-rare-cutaneous-malignancies-in-olmsted-county-minnesota-2000-to-2010
#16
Stanislav N Tolkachjov, Adam R Schmitt, John G Muzic, Amy L Weaver, Christian L Baum
BACKGROUND: The incidence of rare cutaneous malignancies is unknown. Current estimates of rare cutaneous malignancy incidences are based on broad epidemiologic data or single institution experiences, not population-based data. OBJECTIVE: To determine the incidence of several rare nonmelanoma skin cancers. MATERIALS AND METHODS: The authors conducted a retrospective chart review of a population-based cohort between the years 2000 and 2010. Residents of Olmsted County, Minnesota, who were diagnosed with a biopsy-proven nonmelanoma skin cancer-excluding basal cell carcinoma and squamous cell carcinoma-were included in this study...
January 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28027121/carcinogenesis-of-vulvar-lesions-morphology-and-immunohistochemistry-evaluation
#17
Raquel Camara Rivero, Deborah Garcia, Luciano Serpa Hammes, Marcelle Reesink Cerski, Valentino Magno, Lúcia Maria Kliemann, Edison Capp
OBJECTIVES: The aim of the study was to assess the 2 pathways of vulvar carcinogenesis and correlate immunohistochemical expression of p53 with histopathological findings. MATERIALS AND METHODS: This cross-sectional study included 76 cases. Patients were classified according to the 2004 International Society for the Study of Vulvovaginal Disease Terminology, followed by a review of clinical records and immunohistochemical staining for p53. RESULTS: Fifteen cases were in the human papillomavirus (HPV)-associated pathway (12 cases of usual vulvar intraepithelial neoplasia [VIN] and 3 of warty squamous cell carcinoma [SCC]), and 13 cases were in the HPV-independent pathway (5 cases of differentiated VIN and 8 of keratinizing SCC)...
January 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28011467/clinical-implications-of-high-mobility-group-box-1-hmgb1-and-the-receptor-for-advanced-glycation-end-products-rage-in-cutaneous-malignancy-a-systematic-review
#18
REVIEW
Austin Huy Nguyen, Shannon Q Detty, Devendra K Agrawal
Inflammation and the immune system play a role in the development and progression of melanoma, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC). The pro-inflammatory and tumor-promoting effects of the high-mobility group box-1 (HMGB1) protein and the receptor for advanced glycation end products (RAGE) have been investigated in these cutaneous malignancies. The clinical implication of these molecules is not fully described. The National Library of Medicine database was searched for articles addressing the clinical relevance of HMGB1 and RAGE in melanoma, BCC, and SCC...
January 2017: Anticancer Research
https://www.readbyqxmd.com/read/28009668/long-term-topical-corticosteroid-use-and-risk-of-skin-cancer-a-systematic-review-protocol
#19
Sonia Ratib, Esther Burden-Teh, Jo Leonardi-Bee, Catherine Harwood, Fiona Bath-Hextall
The objective of this systematic review is to synthesize the best available research evidence to determine the risk of skin cancer in patients on long-term use of topical corticosteroids. Specifically the review question is: In people using long-term (regular use over one month) topical corticosteroids, what is the risk of developing skin cancer (clinically or histologically confirmed basal cell carcinoma, squamous cell carcinoma or melanoma)?
December 2016: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28005741/two-thirds-lip-defects-a-new-combined-reconstructive-technique-for-patients-with-epithelial-cancer
#20
Tiziana Vitagliano, Lucia Stella Curto, Antonio Greto Ciriaco, Pietro Gareri, Diego Ribuffo, Manfredi Greco
BACKGROUND: The lips are a common site prone to squamous cell carcinomas, which arise in the facial region. There are different techniques to reconstruct the excised lip region, according to dimensions, area, and position of the tumor. The authors describe a new technique of lip reconstruction born from a combination between a nasolabial flap and adipose tissue transplant. METHODS: The study was lead in the Plastic and Reconstructive Surgery Department of the University of Catanzaro...
November 2016: Journal of Craniofacial Surgery
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