keyword
MENU ▼
Read by QxMD icon Read
search

Suspended animation

keyword
https://www.readbyqxmd.com/read/29115131/cultivation-of-the-ribbed-mussel-geukensia-demissa-for-nutrient-bioextraction-in-an-urban-estuary
#1
Eve Galimany, Gary H Wikfors, Mark S Dixon, Carter R Newell, Shannon L Meseck, Dawn Henning, Yaqin Li, Julie M Rose
Shellfish aquaculture is gaining acceptance as a tool to reduce nutrient over enrichment in coastal and estuarine ecosystems through the feeding activity of the animals and assimilation of filtered particles in shellfish tissues. This ecosystem service, provided by the ribbed mussel (Geukensia demissa), was studied in animals suspended from a commercial mussel raft in the urban Bronx River Estuary, NY, in waters closed to shellfish harvest due to bacterial contamination. Naturally occurring populations of ribbed mussels were observed to be healthy and resilient in this highly urbanized environment...
November 8, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29112150/fabrication-of-in-vitro-cancer-microtissue-array-on-fibroblast-layered-nanofibrous-membrane-by-inkjet-printing
#2
Tae-Min Park, Donggu Kang, Ilho Jang, Won-Soo Yun, Jin-Hyung Shim, Young Hun Jeong, Jong-Young Kwak, Sik Yoon, Songwan Jin
In general, a drug candidate is evaluated using 2D-cultured cancer cells followed by an animal model. Despite successful preclinical testing, however, most drugs that enter human clinical trials fail. The high failure rates are mainly caused by incompatibility between the responses of the current models and humans. Here, we fabricated a cancer microtissue array in a multi-well format that exhibits heterogeneous and batch-to-batch structure by continuous deposition of collagen-suspended Hela cells on a fibroblast-layered nanofibrous membrane via inkjet printing...
November 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29111563/multiple-genes-contribute-to-anhydrobiosis-tolerance-to-extreme-desiccation-in-the-nematode-panagrolaimus-superbus
#3
Cláudia Carolina Silva Evangelista, Giovanna Vieira Guidelli, Gustavo Borges, Thais Fenz Araujo, Tiago Alves Jorge de Souza, Ubiraci Pereira da Costa Neves, Alan Tunnacliffe, Tiago Campos Pereira
The molecular basis of anhydrobiosis, the state of suspended animation entered by some species during extreme desiccation, is still poorly understood despite a number of transcriptome and proteome studies. We therefore conducted functional screening by RNA interference (RNAi) for genes involved in anhydrobiosis in the holo-anhydrobiotic nematode Panagrolaimus superbus. A new method of survival analysis, based on staining, and proof-of-principle RNAi experiments confirmed a role for genes involved in oxidative stress tolerance, while a novel medium-scale RNAi workflow identified a further 40 anhydrobiosis-associated genes, including several involved in proteostasis, DNA repair and signal transduction pathways...
November 6, 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29107204/laser-photobiomodulation-of-pro-inflammatory-mediators-on-walker-tumor-256-induced-rats
#4
Maria Carla Petrellis, Lúcio Frigo, Rodrigo Labat Marcos, Rodney Capp Pallotta, Maria Helena Catelli de Carvalho, Marcelo Nicolás Muscará, Durvanei Augusto Maria, Rodrigo Álvaro Brandão Lopes-Martins
Laser photobiomodulation or low-level laser therapy (LLLT) is recognized worldwide for its expansive use in medicine. LLLT has been reported to increase enzymatic activity, increasing the mitochondrial transmembrane potential, leading to an increased energy availability and signal transduction. Nevertheless, an inhibitory effect is also observed by the production of excessive ROS which can result the shutdown of mitochondrial energy production, and finally to apoptosis. However, the mechanism of apoptosis induced by LLLT is still not well understood...
September 18, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29103865/human-endothelial-cell-collection-from-the-middle-cerebral-artery-in-acute-ischemic-stroke
#5
Sunil A Sheth, Abhishek Verma, Konark Malhotra, Xiannan Tang, Satoshi Tateshima, Reza Jahan, Jason D Hinman
BACKGROUND: Endovascular treatment for large-vessel acute ischemic stroke (AIS) has rapidly emerged. However, the understanding of the complex biology involving endothelial cells (ECs) remains scarce. METHODS: Using stent retrievers during endovascular thrombectomy (ET) in patients with AIS, ECs were segregated, centrifuged in a dissociation buffer, and suspended in endothelial specific antibody solution. Subsequently, fluorescence-activated cell sorting (FACS) and microscopic analyses were performed...
November 2, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29066414/z-505-hydrochloride-ameliorates-chemotherapy-induced-anorexia-in-rodents-via-activation-of-the-ghrelin-receptor-ghsr1a
#6
Yoshihiro Shiomi, Yuta Ohira, Makoto Yoshimura, Tomoko Ozaki, Mineo Takei, Takao Tanaka
Despite its therapeutic advantages, chemotherapy with anti-cancer drugs can cause adverse effects, including anorexia and weight loss. Although most patients with cancer suffer from anorexia during chemotherapy, resulting in the need to suspend or cease treatment and thereby worsening prognosis, treatment options for anorexia remain limited. Ghrelin is an orexigenic hormone that has been proposed to prevent anorexia. To investigate the potential of ghrelin receptor agonists, synthetic small-molecule compounds, as preventive therapies for chemotherapy-induced anorexia, we studied the effects of Z-505 hydrochloride (Z-505), a new oral growth hormone secretagogue receptor 1a (GHSR1a) agonist, in cisplatin- and 5-fluorouracil (5-FU)-induced anorexia animal models...
October 21, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29048868/control-of-carbon-nanotube-solvatochromic-response-to-chemotherapeutic-agents
#7
Jackson D Harvey, Hanan A Baker, Elizabeth Mercer, Januka Budhathoki-Uprety, Daniel A Heller
Alkylating agents such as cisplatin play an essential role in chemotherapy regimens, but initial and acquired resistance in many cancer types often dampen therapeutic response. The poor understanding of the mechanisms of resistance highlight the need for quantitative measurements of alkylating agent distribution at both the tissue and subcellular levels. Sensors for use in live animals and cells would allow for more effective study of drug action and resistance. Toward this end, single-walled carbon nanotubes suspended with single-stranded DNA have suitable optical properties for in vivo sensors, such as near-infrared emission and sensitivity to the local environment via solvatochromic responses...
October 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29025328/safety-assessment-of-cross-linked-alkyl-acrylates-as-used-in-cosmetics
#8
Monice M Fiume, Bart Heldreth, Ivan Boyer, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, F Alan Andersen
The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of cross-linked alkyl acrylates as used in cosmetics. The 23 cross-linked alkyl acrylates included in this safety assessment are reported to function as absorbents, film formers, emulsion stabilizers, viscosity increasing agents, suspending agents, binders, and/or skin-conditioning agents. The Panel reviewed available animal and clinical data, as well as information from previous CIR reports on monomer components. Because data were not available for the individual ingredients, and because residual monomer may be present, the Panel extrapolated from previous reports to support safety...
September 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/28979243/phenotypic-and-transcriptomic-responses-of-campylobacter-jejuni-suspended-in-an-artificial-freshwater-medium
#9
Hana Trigui, Kristen Lee, Alexandre Thibodeau, Simon Lévesque, Nilmini Mendis, Philippe Fravalo, Ann Letellier, Sébastien P Faucher
Campylobacter jejuni is the leading cause of campylobacteriosis in the developed world. Although most cases are caused by consumption of contaminated meat, a significant proportion is linked to ingestion of contaminated water. The differences between C. jejuni strains originating from food products and those isolated from water are poorly understood. Working under the hypothesis that water-borne C. jejuni strains are better equipped at surviving the nutrient-poor aquatic environment than food-borne strains, the present study aims to characterize these differences using outbreak strains 81116 and 81-176...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28974933/gaseous-mediators-and-mitochondrial-function-the-future-of-pharmacologically-induced-suspended-animation
#10
REVIEW
Clair Hartmann, Benedikt Nussbaum, Enrico Calzia, Peter Radermacher, Martin Wepler
The role of nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) as poisonous gases is well-established. However, they are not only endogenously produced but also, at low concentrations, exert beneficial effects, such as anti-inflammation, and cytoprotection. This knowledge initiated the ongoing debate, as to whether these molecules, also referred to as "gaseous mediators" or "gasotransmitters," could serve as novel therapeutic agents. In this context, it is noteworthy, that all gasotransmitters specifically target the mitochondria, and that this interaction may modulate mitochondrial bioenergetics, thereby subsequently affecting metabolic function...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28947412/chelonitoxism-in-breast-fed-child-cases-in-mahajanga-madagascar
#11
N G Rasamimanana, J C Randrianandrasana, K D Andrianarimanana, H Rabesandratana, N E Raveloson, A Ralison
Chelonitoxism is a form of food poisoning due to the consumption of sea turtle flesh or viscera, which contain marine toxins called chelonitoxins. Because the passage of these toxins into breast milk is thought to be fatal to breastfed babies, we sought to confirm the possibility of this transmission of toxins through breastfeeding and to determine the symptoms of mothers and the severity of poisoning in babies. A recent case of collective consumption of sea turtle meat from the species Eretmochelys imbricata in western Madagascar affected 76 victims...
August 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28931817/late-neoproterozoic-seawater-oxygenation-by-siliceous-sponges
#12
Michael Tatzel, Friedhelm von Blanckenburg, Marcus Oelze, Julien Bouchez, Dorothee Hippler
The Cambrian explosion, the rapid appearance of most animal phyla in the geological record, occurred concurrently with bottom seawater oxygenation. Whether this oxygenation event was triggered through enhanced nutrient supply and organic carbon burial forced by increased continental weathering, or by species engaging in ecosystem engineering, remains a fundamental yet unresolved question. Here we provide evidence for several simultaneous developments that took place over the Ediacaran-Cambrian transition: expansion of siliceous sponges, decrease of the dissolved organic carbon pool, enhanced organic carbon burial, increased phosphorus removal and seawater oxygenation...
September 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28928637/alpha7-nicotinic-acetylcholine-receptors-play-a-predominant-role-in-the-cholinergic-potentiation-of-n-methyl-d-aspartate-evoked-firing-responses-of-hippocampal-ca1-pyramidal-cells
#13
Zsolt K Bali, Lili V Nagy, István Hernádi
The aim of the present study was to identify in vivo electrophysiological correlates of the interaction between cholinergic and glutamatergic neurotransmission underlying memory. Extracellular spike recordings were performed in the hippocampal CA1 region of anesthetized rats in combination with local microiontophoretic administration of N-methyl-D-aspartate (NMDA) and acetylcholine (ACh). Both NMDA and ACh increased the firing rate of the neurons. Furthermore, the simultaneous delivery of NMDA and ACh resulted in a more pronounced excitatory effect that was superadditive over the sum of the two mono-treatment effects and that was explained by cholinergic potentiation of glutamatergic neurotransmission...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28928280/the-enigma-of-embryonic-diapause
#14
REVIEW
Marilyn B Renfree, Jane C Fenelon
Embryonic diapause - a period of embryonic suspension at the blastocyst stage - is a fascinating phenomenon that occurs in over 130 species of mammals, ranging from bears and badgers to mice and marsupials. It might even occur in humans. During diapause, there is minimal cell division and greatly reduced metabolism, and development is put on hold. Yet there are no ill effects for the pregnancy when it eventually continues. Multiple factors can induce diapause, including seasonal supplies of food, temperature, photoperiod and lactation...
September 15, 2017: Development
https://www.readbyqxmd.com/read/28923308/effect-of-penile-traction-and-vacuum-erectile-device-for-peyronie-s-disease-in-an-animal-model
#15
Haocheng Lin, Chunhui Liu, Run Wang
BACKGROUND: Penile traction therapy with the use of a traction device (TD) or vacuum erectile device (VED) has been studied as local modalities for Peyronie's disease (PD). AIM: To identify changes of penile curvature, erectile function, and possible cellular and molecular mechanisms between the TD and VED in a rat model of PD. METHODS: Peyronie's plaque was induced in 30 adult male rats. Then, rats were randomly divided into control (PD without treatment), VED, and TD groups...
October 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28921522/extraluminal-biodegradable-splint-to-treat-upper-airway-anterior-malacia-a-preclinical-proof-of-principle
#16
François Gorostidi, Cécile Courbon, Marco Burki, Antoine Reinhard, Kishore Sandu
OBJECTIVE: Upper airway malacia highly complicates the treatment of benign laryngotracheal stenosis, and no ideal option is available to date. We here explore the use of extraluminal biodegradable splints in an animal model of long-segment anterior tracheomalacia (TM). We show the efficacy, as well as the tissue tolerance, of a custom-made biodegradable extraluminal device surgically inserted around the trachea. STUDY DESIGN: Preclinical animal study. METHODS: Anterior TM was induced in rabbits through an anterior neck approach by removing eight consecutive anterior tracheal rings without damaging the underlying mucosa...
September 16, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28913839/long-term-stability-of-a-compounded-suspension-of-torsemide-5-mg-ml-for-oral-administration
#17
D Adin, P R Johnson, C H Kim, T Nguyenba, S Rosen
BACKGROUND: Torsemide use for congestive heart failure (CHF) has been reported, but prescription frequency is unknown. Commercially available tablet sizes in North America limit dosing precision, indicating a need to evaluate its strength and stability in suspension. OBJECTIVES: To determine the frequency of torsemide prescriptions and to determine a beyond use date (BUD) of a compounded suspension of torsemide for oral administration stored under 2 temperature conditions for 90 days...
September 15, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28910262/work-minimization-accounts-for-footfall-phasing-in-slow-quadrupedal-gaits
#18
James R Usherwood, Zoe T Self Davies
Quadrupeds, like most bipeds, tend to walk with an even left/right footfall timing. However, the phasing between hind and forelimbs shows considerable variation. Here, we account for this variation by modeling and explaining the influence of hind-fore limb phasing on mechanical work requirements. These mechanics account for the different strategies used by: (1) slow animals (a group including crocodile, tortoise, hippopotamus and some babies); (2) normal medium to large mammals; and (3) (with an appropriate minus sign) sloths undertaking suspended locomotion across a range of speeds...
September 14, 2017: ELife
https://www.readbyqxmd.com/read/28867360/the-use-of-tmz-embedded-hydrogels-for-the-treatment-of-orthotopic-human-glioma-xenografts
#19
Bandita Adhikari, Jie Li, Michael G Brandel, Diahnn Futalan, Johnny Akers, Timothy Deming, Clark C Chen, Bob S Carter
The current treatment of glioblastoma multiforme (GBM) is limited by the restricted arsenal of agents which effectively cross the blood brain barrier (BBB). For example, only a fraction of temozolomide (TMZ) administered systemically is available for therapeutic effect because of the BBB and the instability of TMZ under physiologic conditions. A novel approach to overcome this obstacle is to bypass the BBB and locally deliver chemotherapeutic agents directly to the tumor mass. We have explored the loading of TMZ into a novel hydrogel matrix, which can be delivered in liquid form and then solidifies in situ and releases chemotherapy as the matrix dissolves...
November 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28859901/use-of-hydrogel-scaffolds-to-develop-an-in-vitro-3d-culture-model-of-human-intestinal-epithelium
#20
R H Dosh, A Essa, N Jordan-Mahy, C Sammon, C L Le Maitre
The human intestinal cell lines: Caco-2 and HT29-MTX cells have been used extensively in 2D and 3D cell cultures as simple models of the small intestinal epithelium in vitro. This study aimed to investigate the potential of three hydrogel scaffolds to support the 3D culture of Caco-2 and HT29-MTX cells and critically assess their use as scaffolds to stimulate villi formation to model a small intestinal epithelium in vitro. Here, alginate, l-pNIPAM, and l-pNIPAM-co-DMAc hydrogels were investigated. The cells were suspended within or layered on these hydrogels and maintained under static or dynamic culture conditions for up to 21days...
August 30, 2017: Acta Biomaterialia
keyword
keyword
4562
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"