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https://www.readbyqxmd.com/read/28741242/the-weakening-effect-of-soluble-epoxide-hydrolase-inhibitor-auda-on-febrile-response-to-lipopolysaccharide-and-turpentine-in-rat
#1
Jakub Piotrowski, Tomasz Jędrzejewski, Małgorzata Pawlikowska, Agata Joanna Pacuła, Jacek Ścianowski, Wiesław Kozak
A still growing body of evidence suggests the importance of epoxyeicosatrienoic acids (EETs) in the regulation of inflammatory response; therefore, drugs that stabilize their levels by targeting the soluble epoxide hydrolase (sEH), an enzyme responsible for their metabolism, are currently under investigation. The effect of sEH inhibitors on molecular components of fever mechanism, i.e., on synthesis of pro-inflammatory cytokines or prostaglandins, has been repeatedly proven; however, the hypothesis that sEH inhibitors affect febrile response has never been tested...
July 24, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28738837/assessment-of-cerebral-circulation-in-a-porcine-model-of-intravenously-given-e-coli-induced-fulminant-sepsis
#2
Levente Molnár, Norbert Németh, Mariann Berhés, Endre Hajdú, Lóránd Papp, Ábel Molnár, Judit Szabó, Ádám Deák, Béla Fülesdi
BACKGROUND: The aim of the present work was to assess cerebral hemodynamic changes in a porcine model of E.coli induced fulminant sepsis. METHODS: Nineteen healthy female Hungahib pigs, 10-12 weeks old, randomly assigned into two groups: Control (n = 9) or Septic Group (n = 10). In the Sepsis group Escherichia coli culture suspended in physiological saline was intravenously administrated in a continuously increasing manner according to the following protocol: 2 ml of bacterial culture suspended in physiological saline was injected in the first 30 min, then 4 ml of bacterial culture was administered within 30 min, followed by infusion of 32 ml bacterial culture for 2 h...
July 24, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28728387/effects-of-environmental-enrichment-on-behaviour-physiology-and-performance-of-pigs-a-review
#3
Mbusiseni Vusumuzi Mkwanazi, Cyprial Ndumiso Ncobela, Arnold Tapera Kanengoni, Michael Chimonyo
The aim of this paper is to critically analyse and synthesise existing knowledge concerning the use of environmental enrichment and its effect on behaviour, physiology and performance of pigs housed in intensive production systems. The objective is also to provide clarity as to what constitute successful enrichment and recommend on when and how enrichment should be used. Environmental enrichment is usually understood as an attempt to improve animal welfare and to lesser extent, performance. Common enrichment objects used are straw bedding, suspended rope and wood shavings, toys, rubber tubing, coloured plastic keys, table tennis balls, chains and strings...
June 26, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28717055/incidence-of-anaphylactic-reactions-after-propofol-administration-in-dogs
#4
Mamoru Onuma, Misao Terada, Sadaharu Ono, Akiyoshi Murakami, Tomoko Ishida, Tadashi Sano
Propofol is an anesthetic agent suspended in an emulsion system that includes egg yolk lecithin and soybean oil, because of which, there is concern about the use of propofol in patients allergic to these substances. We examined the association between propofol administration and incidence of adverse events in dogs with allergy to egg yolk lecithin and soybean oil. On the basis of the findings of an allergen-specific immunoglobulin E (IgE) test, 14 dogs with high levels (high-IgE group) and 7 dogs with low levels (normal-IgE group) of IgE were selected...
July 14, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28682114/effectiveness-of-topical-application-of-ostrich-oil-on-the-healing-of-staphylococcus-aureus-and-pseudomonas-aeruginosa-infected-wounds
#5
Mohammad Reza Farahpour, Mahsa Vahid, Ahmad Oryan
BACKGROUND/AIMS: Management of infected wounds is one of the major challenges that surgeons and nurses face. Several antimicrobial agents have been used, but the toxicity, drug resistance and their effect on the healing process remain a matter of concern. The present study was designed to analyze the accelerative impact of topical application of Ostrich oil on infected wounds in a mouse model. MATERIALS AND METHODS: 72 BALB/c mice were divided into 4 main groups of control-sham, mupirocin and two treatment groups receiving 2% and 4% (V/W) concentrations of Ostrich oil, topically...
July 6, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/28646777/predicting-improved-optical-water-quality-in-rivers-resulting-from-soil-conservation-actions-on-land
#6
J R Dymond, R J Davies-Colley, A O Hughes, C D Matthaei
Deforestation in New Zealand has led to increased soil erosion and sediment loads in rivers. Increased suspended fine sediment in water reduces visual clarity for humans and aquatic animals and reduces penetration of photosynthetically available radiation to aquatic plants. To mitigate fine-sediment impacts in rivers, catchment-wide approaches to reducing soil erosion are required. Targeting soil conservation for reducing sediment loads in rivers is possible through existing models; however, relationships between sediment loads and sediment-related attributes of water that affect both ecology and human uses of water are poorly understood...
June 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28615133/platelet-rich-plasma-with-keratinocytes-and-fibroblasts-enhance-healing-of-full-thickness-wounds
#7
Jia Xian Law, Shiplu Roy Chowdhury, Aminuddin Bin Saim, Ruszymah Bt Hj Idrus
Advances in tissue engineering led to the development of various tissue-engineered skin substitutes (TESS) for the treatment of skin injuries. The majority of the autologous TESS required lengthy and costly cell expansion process to fabricate. In this study, we determine the possibility of using a low density of human skin cells suspended in platelet-rich plasma (PRP)-enriched medium to promote the healing of full-thickness skin wounds. To achieve this, full-thickness wounds of size 1.767 cm(2) were created at the dorsum part of nude mice and treated with keratinocytes (2 × 10(4) cells/cm(2)) and fibroblasts (3 × 10(4) cells/cm(2)) suspended in 10% PRP-enriched medium...
June 7, 2017: Journal of Tissue Viability
https://www.readbyqxmd.com/read/28613846/unimolecular-micelle-based-hybrid-system-for-perivascular-drug-delivery-produces-long-term-efficacy-for-neointima-attenuation-in-rats
#8
Guojun Chen, Xudong Shi, Bowen Wang, Ruosen Xie, Lian-Wang Guo, Shaoqin Gong, K Craig Kent
At present, there are no clinical options for preventing neointima-caused (re)stenosis after open surgery such as bypass surgery for treating flow-limiting vascular disease. Perivascular drug delivery is a promising strategy, but in translational research, it remains a major challenge to achieve long-term (e.g., > 3 months) anti(re)stenotic efficacy. In this study, we engineered a unique drug delivery system consisting of durable unimolecular micelles, formed by single multiarm star amphiphilic block copolymers with only covalent bonds, and a thermosensitive hydrogel formed by a poly(lactide-co-glycolide)-poly(ethylene glycol)-poly(lactide-co-glycolide) triblock copolymer (abbreviated as triblock gel) that is stable for about 4 weeks in vitro...
June 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28608861/neonatal-pinealectomy-in-rats-a-simple-micro-suction-technique
#9
Bohdan Pawlicki, Brandon Michael Henry, Krzysztof A Tomaszewski, Mariusz Gajda, Iwona Brzozowska, Jerzy A Walocha, Anna Skowron-Cendrzak
To determine the role of the pineal gland and its secretory product melatonin on various aspects of the functioning of the organism, the gland can be easily surgically removed in rats within 18 hours after birth. We performed pinealectomy in rats in a state of deep hypothermia under an operating microscope, using a micro-suction device of our own construction. The rats were induced into a state of suspended animation by placing them in the freezing compartment at minus 20 Celsius degrees. The cessation of respiration and heart beat lasted for about 15 minutes...
2017: Folia Medica Cracoviensia
https://www.readbyqxmd.com/read/28606009/a-novel-method-of-suspending-sheep-for-clinical-research
#10
Chris Christou, William R Walsh
The slinging of sheep is a commonly reported, yet poorly described procedure, which is useful for the advancement of veterinary and medical preclinical research. We have described a novel, flexible and repeatable method of suspending sheep to varying degrees while not affecting mobility and thereby improving animal husbandry and welfare.
January 1, 2017: Laboratory Animals
https://www.readbyqxmd.com/read/28573043/a-safety-evaluation-of-profound-hypothermia-induced-suspended-animation-for-delayed-resuscitation-at-90-or-120%C3%A2-min
#11
Yu Liu, Shu Li, Zhi Li, Jian Zhang, Jin-Song Han, Yong Zhang, Zong-Tao Yin, Hui-Shan Wang
BACKGROUND: The successful treatment of military combat casualties with penetrating injuries is significantly dependent on the time needed to get the patient to an adequate treatment facility. Profound hypothermia-induced suspended animation for delayed resuscitation (SADR) is a novel approach for inducing cardiac arrest and buying additional time for such injuries. However, the time used to safely administer circulatory arrest (CA) is controversial. The goal of this study was to evaluate the safety of hypothermia-induced SADR over 90 and 120 min time intervals...
2017: Military Medical Research
https://www.readbyqxmd.com/read/28569502/prevention-of-bacterial-colonization-on-catheters-by-a-one-step-coating-process-involving-an-antibiofouling-polymer-in-water
#12
Hyeongseop Keum, Jin Yong Kim, Byeongjun Yu, Seung Jung Yu, Jinjoo Kim, Hyungsu Jeon, Dong Yun Lee, Sung Gap Im, Sangyong Jon
As reports of multidrug resistant pathogens have increased, patients with implanted medical catheters increasingly need alternative solutions to antibiotic treatments. As most catheter-related infections are directly associated with biofilm formation on the catheter surface, which, once formed, is difficult to eliminate, a promising approach to biofilm prevention involves inhibiting the initial adhesion of bacteria to the surface. In this study, we report an amphiphilic, antifouling polymer, poly(DMA-mPEGMA-AA) that can facilely coat the surfaces of commercially available catheter materials in water and prevent bacterial adhesion to and subsequent colonization of the surface, giving rise to an antibiofilm surface...
June 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28558931/freeze-responsive-regulation-of-mef2-proteins-and-downstream-gene-networks-in-muscles-of-the-wood-frog-rana-sylvatica
#13
Oscar A Aguilar, Hanane Hadj-Moussa, Kenneth B Storey
The wood frog survives frigid North American winters by retreating into a state of suspended animation characterized by the freezing of up to 65% of total body water as extracellular ice and displaying no heartbeat, breathing, brain activity, or movement. Physiological and biochemical adaptations are in place to facilitate global metabolic depression and protect against the consequences of whole body freezing. This study examined the myocyte enhancer factor 2 (MEF2) transcription factor family, proteins responsible for coordinating selective gene expression of a myriad of cellular functions from muscle development and remodelling to various stress responses...
July 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28557571/in-vivo-efficacy-of-an-injectable-microsphere-hydrogel-ocular-drug-delivery-system
#14
Christian R Osswald, Micah J Guthrie, Abigail Avila, Joseph A Valio, William F Mieler, Jennifer J Kang-Mieler
PURPOSE: Demonstrate in vivo that controlled and extended release of a low dose of anti-vascular endothelial growth factor (anti-VEGF) from a microsphere-hydrogel drug delivery system (DDS) has a therapeutic effect in a laser-induced rat model of choroidal neovascularization (CNV). METHODS: Anti-VEGF (ranibizumab or aflibercept) was loaded into poly(lactic-co-glycolic acid) microspheres that were then suspended within an injectable poly(N-isopropylacrylamide)-based thermo-responsive hydrogel DDS...
May 30, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28528530/evaluation-of-ratite-skinning-force-in-order-to-fix-plant-and-mechanical-solutions
#15
Biagio Bianchi
The skin is the most requested product of ratite slaughter and 'first-rate' ratite's skin has a high economic market. Ostrich hide is tanned in South Africa and sold all over the world. Besides, the ostrich meat is considered a niche production in the marketplace, thus allowing for another pro t for the ostrich breeding. Theorical analysis of skinning process has been carried out, and an automatic measurement system has been designed to record the drawing-force on the animal's body during skinning tests. The aim of this study was to indentify the best animal position and provide values of drawing-force in order to design a speci c machine for ostrich skinning...
May 12, 2017: Veterinaria Italiana
https://www.readbyqxmd.com/read/28513757/-new-drugs-for-horses-and-production-animals-in-2016
#16
Ilka Ute Emmerich
In 2016, only one newly developed active pharmaceutical ingredient for horses and food-producing animals was released on the German market for veterinary drug products. The immunomodulator Pegbovigrastim is now available as an injection solution for cattle (Imrestor(®)). Four established veterinary active pharmaceutical ingredients are available for further species: the ectoparasitic Amitraz (Apitraz(®)) from the triazapentadiene group was additionally authorized for honeybees, the expectorant Bromhexine (Exflow(®) Vet) for chickens, turkeys and ducks and the macrolide antibiotic Gamithromycin (Zactran(®)) for pigs...
June 20, 2017: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/28505878/suspended-solid-concentration-reduces-feeding-in-freshwater-mussels
#17
Shaylah Tuttle-Raycraft, Todd J Morris, Josef D Ackerman
We examined the effect of TSS concentration on the clearance rates (CR) of newly transformed juvenile and adult Lampsilis fasciola, L. siliquoidea, Ligumia nasuta, and Villosa iris, as increased total suspended solids (TSS) are thought to interfere with feeding processes. Mussel CR were measured in aerated (or swirled for juveniles) chambers at TSS concentrations up to 15mgL(-1) for laboratory-transformed juveniles, and up to 100mgL(-1) for adult mussels. The CR of one-week old animals increased with TSS concentration, likely due to ontological differences in feeding (pedal vs...
November 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28502905/inhibition-of-proinflammatory-mediators-by-coumaroyl-lupendioic-acid-a-new-lupane-type-triterpene-from-careya-arborea-on-inflammation-induced-animal-model
#18
Rayhana Begum, Manjur Ali Sheliya, Showkat R Mir, Ekta Singh, Manju Sharma
ETHNOPHARMACOLOGICAL RELEVANCE: Careya arborea Roxb. (Lecythidaceae) is a large tree found throughout India in deciduous forests and grasslands. C. arborea is traditionally used in tumors, inflammation, anthelmintic, bronchitis, epileptic fits, astringents, antidote to snake-venom, skin disease, diarrhea, dysentery with bloody stools, dyspepsia, ulcer, tooth ache, and ear pain. AIM OF THE STUDY: In our previous work, the methanolic extract of Careya arborea stem bark showed significant anti-inflammatory activity...
July 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28497366/evaluation-of-persistence-and-distribution-of-intra-dermally-administered-pkh26-labelled-goat-bone-marrow-derived-mesenchymal-stem-cells-in-cutaneous-wound-healing-model
#19
M D Pratheesh, Nitin E Gade, Amar Nath, Pawan K Dubey, T B Sivanarayanan, D N Madhu, T R Sreekumar, Amarpal, G Saikumar, G Taru Sharma
The current study was designed to study the persistence and distribution of caprine bone marrow derived mesenchymal stem cells (cBM-MSCs) when administered intra-dermally in experimentally induced cutaneous wounds in rabbits. MSC's from goat bone marrow were isolated and their differentiation potential towards adipogenic and osteogenic lineages were assayed in vitro. The isolated cells were phenotypically analysed using flow cytometry for the expression of MSC specific matrix receptors (CD73, CD105 and Stro-1) and absence of hematopoietic lineage markers...
May 11, 2017: Cytotechnology
https://www.readbyqxmd.com/read/28495952/deep-and-profound-hypothermia-in-haemorrhagic-shock-friend-or-foe-a-systematic-review
#20
REVIEW
Samuel E Moffatt, S J B Mitchell, J L Walke
INTRODUCTION: Survival in exsanguinating cardiac arrest patients is poor, as is neurological outcome in survivors. Hypothermia has traditionally been seen as harmful to trauma patients and associated with increased mortality; however, there has been speculation that cooling to very low temperatures (≤20°C) could be used to treat haemorrhagic trauma patients by the induction of a suspended animation period through extreme cooling, which improves survival and preserves neurological function...
May 11, 2017: Journal of the Royal Army Medical Corps
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