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https://www.readbyqxmd.com/read/28549024/the-epidemiology-of-hospital-death-following-pediatric-severe-sepsis-when-why-and-how-children-with-sepsis-die
#1
Scott L Weiss, Fran Balamuth, Josey Hensley, Julie C Fitzgerald, Jenny Bush, Vinay M Nadkarni, Neal J Thomas, Mark Hall, Jennifer Muszynski
OBJECTIVE: The epidemiology of in-hospital death after pediatric sepsis has not been well characterized. We investigated the timing, cause, mode, and attribution of death in children with severe sepsis, hypothesizing that refractory shock leading to early death is rare in the current era. DESIGN: Retrospective observational study. SETTING: Emergency departments and ICUs at two academic children's hospitals. PATIENTS: Seventy-nine patients less than 18 years old treated for severe sepsis/septic shock in 2012-2013 who died prior to hospital discharge...
May 25, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28548990/outbreaks-of-nontuberculous-mycobacteria
#2
Geeta Sood, Nikki Parrish
PURPOSE OF REVIEW: The purpose of this review is to summarize the emerging literature on nontuberculous mycobacteria outbreaks in healthcare settings. As our ability to identify mycobacterial species develops, we are better able to recognize epidemiologic connections and better understand the prevalence and importance of these outbreaks and pseudo-outbreaks in healthcare settings. RECENT FINDINGS: The number of outbreaks related to nontuberculous outbreaks is increasing because of heightened awareness and better diagnostic tests for species level identification of mycobacteria...
May 25, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28548927/the-impact-of-delayed-commencement-of-adjuvant-chemotherapy-eight-or-more-weeks-on-survival-in-stage-ii-and-iii-colon-cancer-a-national-population-based-cohort-study
#3
Young Wan Kim, Eun Hee Choi, Bo Ra Kim, Woo-Ah Ko, Yeong-Mee Do, Ik Yong Kim
BACKGROUND: To examine the impact of chemotherapy delay on survival in patients with stage II or III colon cancer and the factors associated with the delay (≥8 weeks) of adjuvant chemotherapy. METHODS: Patients undergoing curative resection and adjuvant chemotherapy in a national population-based cohort were included. RESULTS: Among 5355 patients, 154 (2.9%) received chemotherapy more than 8 weeks after surgery. Based on a multivariate analysis, the risk factors associated with chemotherapy delay ≥8 weeks were older age [65 to 74 years (hazard ratio [HR]=1...
May 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28548893/dynamic-decision-making-learning-processes-and-new-research-directions
#4
Cleotilde Gonzalez, Pegah Fakhari, Jerome Busemeyer
OBJECTIVE: The aim of this manuscript is to provide a review of contemporary research and applications on dynamic decision making (DDM). BACKGROUND: Since early DDM studies, there has been little systematic progress in understanding decision making in complex, dynamic systems. Our review contributes to better understanding of decision making processes in dynamic tasks. METHOD: We discuss new research directions in DDM to highlight the value of simplification in the study of complex decision processes, divided into experimental and theoretical/computational approaches, and focus on problems involving control tasks and search-and-choice tasks...
May 1, 2017: Human Factors
https://www.readbyqxmd.com/read/28548368/developing-minimum-clinical-standards-for-physiotherapy-in-south-african-icus-a-qualitative-study
#5
Heleen van Aswegen, Shane Patman, Natascha Plani, Susan Hanekom
RATIONALE, AIMS, AND OBJECTIVES: Physiotherapists are integral members of the intensive care unit (ICU) team. Clinicians working in ICU are dependent on their own experience when making decisions regarding individual patient management thus resulting in variation in clinical practice. No formalized clinical practice guidelines or standards exist for the educational profile or scope of practice requirements for ICU physiotherapy. This study explored perceptions of physiotherapists on minimum clinical standards that ICU physiotherapists should adhere to for delivering safe, effective physiotherapy services to critically ill patients...
May 26, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28547840/performance-of-norwegian-civilian-emts-and-army-medics-in-penetrating-trauma-a-controlled-simulation-based-assessment
#6
S W Blix, J Melau, I Lund-Kordahl
BACKGROUND: Penetrating trauma kills rapidly. Thorough and efficient examination and aggressive hemorrhage control is important to save lives. The aim of this study was to assess the skills of civilian Emergency Medical Technicians (EMTs) in bleeding examination and control compared to Army Medics. Our hypothesis was that civilian pre-hospital systems perform at a lower level compared to an expert group, and did not have sufficient focus on education and training in examination and treatment of penetrating injuries...
May 25, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28547702/emerging-treatments-in-eating-disorders
#7
REVIEW
Michael Lutter
Eating disorders (EDs), including anorexia nervosa, bulimia nervosa, and binge-eating disorder, constitute a class of common and deadly psychiatric disorders. While numerous studies in humans highlight the important role of neurobiological alterations in the development of ED-related behaviors, the precise neural substrate that mediates this risk is unknown. Historically, pharmacological interventions have played a limited role in the treatment of eating disorders, typically providing symptomatic relief of comorbid psychiatric issues, like depression and anxiety, in support of the standard nutritional and psychological treatments...
May 25, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28546591/the-healthcare-system-and-the-provision-of-oral-healthcare-in-european-union-member-states-part-8-italy
#8
M Bindi, C Paganelli, K A Eaton, E Widström
In Italy healthcare is provided for all Italian citizens and residents and it is delivered mainly by public providers, with some private or private-public entities. Italy's public healthcare system - the Servizio Sanitario Nazionale (SSN) - is organised by the Ministry of Health and administered on a devolved regional basis. It is financed by general taxation that provides universal coverage, largely free of charge at the point of service. The central government establishes the basic national health benefits package, which must be uniformly provided throughout the country, through services guaranteed under the NHS provision called LEA - (Livelli Essenziali di Assistenza [Essential Level of Assistance]) and allocates national funds to the regions...
May 26, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28546381/adjunct-therapies-for-refractory-status-asthmaticus-in-children
#9
Kyle J Rehder
Asthma exacerbation is a common reason for children to present to the emergency department. If primary therapies fail to halt the progression of an asthma flare, status asthmaticus often leads to hospital, and potentially ICU, admission. Following the initial administration of inhaled β agonists and systemic corticosteroids, a wide array of adjunct medical therapies may be used to treat status asthmaticus. Unfortunately, the data supporting the use of these adjunct therapies are often unclear, conflicting, or absent...
June 2017: Respiratory Care
https://www.readbyqxmd.com/read/28546075/antimicrobial-storage-and-antibiotic-knowledge-in-the-community-a-cross-sectional-pilot-study-in-north-western-angola
#10
Joana Cortez, Edite Rosário, João E Pires, João Taborda Lopes, Moisés Francisco, Erika Vlieghe, Miguel Brito
BACKGROUND: Antimicrobials are drugs that were once lifesavers and mainly curative. Nowadays their value is increasingly under pressure because of the fast and worldwide emergence of antimicrobial resistance, which, in low resources settings, frequently occurs in microorganisms that are likely to be transmitted in the community. METHODS: A cross-sectional pilot study including 102 households within the 10th HDSS round in Dande, Bengo Province, Angola. RESULTS: From the total 102 households piloted, 77...
May 22, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28546042/occluded-superficial-femoral-artery-used-for-emergency-reconstruction-a-consecutive-case-series-about-the-proper-conduit-technique
#11
M S Marsman, A Kh Jahrome, F L Moll, G G Koning
INTRODUCTION: Deep wound infections in the groin region can result in an acute or life threatening condition. Especially when there is no suitable vein available because of many reasons (e.g. previous surgery, small vessel diameter). Synthetic prosthesis sometimes are not 'first-choice-technique' because of contamination or infection. It was ad hoc hypothesized in an acute setting that a segment of an occluded Superficial Femoral Artery (SFA) could be used as a conduit in combination with eversion technique, known from carotid surgery...
May 22, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28545930/the-knowledge-desired-by-emergency-medical-service-managers-of-their-ambulance-clinicians-a-modified-delphi-study
#12
Mats Holmberg, Ingegerd Fagerberg, Anna Carin Wahlberg
AIM: The aim of the study was to identify the types of knowledge that Swedish Emergency Medical Service (EMS) managers considered desirable in their Ambulance Clinicians. BACKGROUND: Emergency medical service managers are responsible for organisational tasking and in this are dependent on the knowledge possessed by their ambulance clinicians. It would therefore be of value to explore EMS managers' approach to this knowledge. DESIGN: A modified Delphi method in three rounds...
May 22, 2017: International Emergency Nursing
https://www.readbyqxmd.com/read/28545851/sex-specific-risk-of-emergency-department-revisits-and-early-readmission-following-myocardial-infarction
#13
Magnus Lundbäck, Danijela Gasevic, Eric Rullman, Toralph Ruge, Axel C Carlsson, Martin J Holzmann
BACKGROUND: Readmissions within 30days after hospitalization have been introduced as a measure of quality of care. There is a paucity of data regarding sex-specific risk of early readmissions after myocardial infarction (MI). OBJECTIVES: To investigate the association between sex and revisits to the emergency department (ED), and readmissions after MI. METHODS: All patients with chest pain, diagnosed with MI at the Karolinska University Hospital during 2011 and 2012 were included...
May 19, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28545597/prefrontal-cortical-thinning-links-to-negative-symptoms-in-schizophrenia-via-the-enigma-consortium
#14
E Walton, D P Hibar, T G M van Erp, S G Potkin, R Roiz-Santiañez, B Crespo-Facorro, P Suarez-Pinilla, N E M van Haren, S M C de Zwarte, R S Kahn, W Cahn, N T Doan, K N Jørgensen, T P Gurholt, I Agartz, O A Andreassen, L T Westlye, I Melle, A O Berg, L Morch-Johnsen, A Færden, L Flyckt, H Fatouros-Bergman, E G Jönsson, R Hashimoto, H Yamamori, M Fukunaga, N Jahanshad, P De Rossi, F Piras, N Banaj, G Spalletta, R E Gur, R C Gur, D H Wolf, T D Satterthwaite, L M Beard, I E Sommer, S Koops, O Gruber, A Richter, B Krämer, S Kelly, G Donohoe, C McDonald, D M Cannon, A Corvin, M Gill, A Di Giorgio, A Bertolino, S Lawrie, T Nickson, H C Whalley, E Neilson, V D Calhoun, P M Thompson, J A Turner, S Ehrlich
BACKGROUND: Our understanding of the complex relationship between schizophrenia symptomatology and etiological factors can be improved by studying brain-based correlates of schizophrenia. Research showed that impairments in value processing and executive functioning, which have been associated with prefrontal brain areas [particularly the medial orbitofrontal cortex (MOFC)], are linked to negative symptoms. Here we tested the hypothesis that MOFC thickness is associated with negative symptom severity...
May 26, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28545584/can-community-health-workers-play-a-greater-role-in-increasing-access-to-medical-abortion-services-a-qualitative-study
#15
Pallavi Gupta, Sharad D Iyengar, Bela Ganatra, Heidi Bart Johnston, Kirti Iyengar
BACKGROUND: Despite being legally available in India since 1971, barriers to safe and legal abortion remain, and unsafe and/or illegal abortion continues to be a problem. Community health workers have been involved in improving access to health information and care for maternal and child health in resource poor settings, but their role in facilitating accurate information about and access to safe abortion has been relatively unexplored. A qualitative study was conducted in Rajasthan, India to study acceptability, perspectives and preferences of women and community health workers, regarding the involvement of community health workers in medical abortion referrals...
May 25, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28545572/intensive-case-management-for-addiction-to-promote-engagement-with-care-of-people-with-severe-mental-and-substance-use-disorders-an-observational-study
#16
Stéphane Morandi, Benedetta Silva, Philippe Golay, Charles Bonsack
BACKGROUND: Co-occurring severe mental and substance use disorders are associated with physical, psychological and social complications such as homelessness and unemployment. People with severe mental and substance use disorders are difficult to engage with care. The lack of treatment worsens their health and social conditions and increases treatment costs, as emergency department visits arise. Case management has proved to be effective in promoting engagement with care of people with severe mental and substance use disorders...
May 25, 2017: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/28545355/emerging-trends-on-drug-delivery-strategy-of-momordica-charantia-against-diabetes-and-its-complications
#17
Zar Chi Thent, Srijit Das, Nurul Hannim Zaidun
The incidence of diabetes mellitus has increased drastically over the past few decades. This oxidant-antioxidant imbalance resulting in complication of diabetes mellitus includes macro- and microvascular complications. Resistance to conventional treatment and patient compliance has paved the way to the usage of effective natural products and supplements. Momordica charantia (bitter gourd) is widely consumed in many parts of Malaysia as a vegetable. Momordica charantia (MC) is mainly used in the management of diabetes mellitus...
May 25, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28544581/a-comparison-of-the-pharmacokinetics-of-methylphenidate-extended-release-orally-disintegrating-tablets-with-a-reference-extended-release-formulation-of-methylphenidate-in-healthy-adults
#18
Ann Childress, Jeffrey G Stark, Russ McMahen, Dorothy Engelking, Carolyn Sikes
Extended-release (ER) methylphenidate (MPH) is a first-line treatment for attention-deficit/hyperactivity disorder. A methylphenidate extended-release orally disintegrating tablet (MPH XR-ODT) has recently been developed. This was a randomized, open-label, 3-period, 3-treatment study comparing the bioavailability and absorption of 2 MPH XR-ODT formulations with an MPH ER reference medication. Here we report the 2 treatments comparing the commercial MPH XR-ODT formulation and reference medication. Following a ≥10-hour fast, 42 healthy adults received 60 mg of reference medication or MPH XR-ODT (2 × 30 mg)...
May 25, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/28544321/assessment-of-mode-of-delivery-and-predictors-of-emergency-caesarean-section-among-women-living-with-hiv-in-a-matched-pair-setting-with-women-from-the-general-population-in-denmark-2002-2014
#19
M Ørbaek, K Thorsteinsson, M Helleberg, E Moseholm, T L Katzenstein, M Storgaard, I S Johansen, G Pedersen, N Weis, A-M Lebech
OBJECTIVES: We aimed to assess mode of delivery and predictors of emergency caesarean section (EmCS) in women living with HIV (WLWH) in a matched-pair setting with women from the general population (WGP) in Denmark. Further, we analysed birth plan in WLWH. METHODS: All WLWH giving birth to live-born children from 2002 to 2014 were included in the study. Data were retrieved from medical records and national registries. WLWH were matched 1:5 by age, birth year, parity and ethnicity to WGP...
May 24, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28544279/controlled-clinical-trial-exploring-the-impact-of-a-brief-intervention-for-prevention-of-falls-in-an-emergency-department
#20
Kristie J Harper, Annette D Barton, Glenn Arendts, Deborah G Edwards, Antonio C Petta, Antonio Celenza
OBJECTIVE: To establish the effectiveness of a brief intervention to prevent falls in older patients presenting to the ED post-discharge. METHODS: The present study is a prospective single-centre, quasi-randomised controlled clinical trial of a brief targeted educational intervention to prevent falls. The intervention group received brief scripted education and were advised of their percentage probability of falling in the next 6 months. The key message was to reinforce the importance of falls prevention strategies and the seriousness of falls...
May 23, 2017: Emergency Medicine Australasia: EMA
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