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autism tractography

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https://www.readbyqxmd.com/read/29116187/a-translational-study-on-looming-evoked-defensive-response-and-the-underlying-subcortical-pathway-in-autism
#1
Yu Hu, Zhuoming Chen, Lu Huang, Yue Xi, Bingxiao Li, Hong Wang, Jiajian Yan, Tatia M C Lee, Qian Tao, Kwok-Fai So, Chaoran Ren
Rapidly approaching objects indicating threats can induce defensive response through activating a subcortical pathway comprising superior colliculus (SC), lateral posterior nucleus (LP), and basolateral amygdala (BLA). Abnormal defensive response has been reported in autism, and impaired synaptic connections could be the underlying mechanism. Whether the SC-LP-BLA pathway processes looming stimuli abnormally in autism is not clear. Here, we found that looming-evoked defensive response is impaired in a subgroup of the valproic acid (VPA) mouse model of autism...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29079524/whole-brain-white-matter-connectivity-analysis-using-machine-learning-an-application-to-autism
#2
Fan Zhang, Peter Savadjiev, Weidong Cai, Yang Song, Yogesh Rathi, Birkan Tunç, Drew Parker, Tina Kapur, Robert T Schultz, Nikos Makris, Ragini Verma, Lauren J O'Donnell
In this paper, we propose an automated white matter connectivity analysis method for machine learning classification and characterization of white matter abnormality via identification of discriminative fiber tracts. The proposed method uses diffusion MRI tractography and a data-driven approach to find fiber clusters corresponding to subdivisions of the white matter anatomy. Features extracted from each fiber cluster describe its diffusion properties and are used for machine learning. The method is demonstrated by application to a pediatric neuroimaging dataset from 149 individuals, including 70 children with autism spectrum disorder (ASD) and 79 typically developing controls (TDC)...
October 25, 2017: NeuroImage
https://www.readbyqxmd.com/read/29027066/white-matter-microstructure-of-the-human-mirror-neuron-system-is-related-to-symptom-severity-in-adults-with-autism
#3
Odette Fründt, Robert Schulz, Daniel Schöttle, Bastian Cheng, Götz Thomalla, Hanna Braaß, Christos Ganos, Nicole David, Ina Peiker, Andreas K Engel, Tobias Bäumer, Alexander Münchau
Mirror neuron system (MNS) dysfunctions might underlie deficits in autism spectrum disorders (ASD). Diffusion tensor imaging based probabilistic tractography was conducted in 15 adult ASD patients and 13 matched, healthy controls. Fractional anisotropy (FA) was quantified to assess group differences in tract-related white matter microstructure of both the classical MNS route (mediating "emulation") and the alternative temporo-frontal route (mediating "mimicry"). Multiple linear regression was used to investigate structure-function relationships between MNS connections and ASD symptom severity...
October 12, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28741714/abnormal-fronto-parietal-white-matter-organisation-in-the-superior-longitudinal-fasciculus-branches-in-autism-spectrum-disorders
#4
Jacqueline Fitzgerald, Alexander Leemans, Elizabeth Kehoe, Erik O'Hanlon, Louise Gallagher, Jane McGrath
Core features of ASD may be underpinned by disrupted functional and structural neural connectivity. Abnormal fronto-parietal functional connectivity has been widely reported in the literature; this may be underpinned by disrupted microstructural organisation of white matter. The Superior Longitudinal Fasciculus (SLF) is a major fronto-parietal white matter tract, the structure of which has been little studied in ASD. The fronto-parietal projections of this tract (SLF I, II and III) are thought to play an important role in a number of cognitive functions including attention and visuospatial processing...
July 25, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28695417/a-fiber-tractography-study-of-social-emotional-related-fiber-tracts-in-children-and-adolescents-with-autism-spectrum-disorder
#5
Yun Li, Hui Fang, Wenming Zheng, Lu Qian, Yunhua Xiao, Qiaorong Wu, Chen Chang, Chaoyong Xiao, Kangkang Chu, Xiaoyan Ke
The symptoms of autism spectrum disorder (ASD) have been hypothesized to be caused by changes in brain connectivity. From the clinical perspective, the "disconnectivity" hypothesis has been used to explain characteristic impairments in "socio-emotional" function. Therefore, in this study we compared the facial emotional recognition (FER) feature and the integrity of social-emotional-related white-matter tracts between children and adolescents with high-functioning ASD (HFA) and their typically developing (TD) counterparts...
July 10, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28630661/intrainsular-connectivity-and-somatosensory-responsiveness-in-young-children-with-asd
#6
Michelle D Failla, Brittany R Peters, Haleh Karbasforoushan, Jennifer H Foss-Feig, Kimberly B Schauder, Brynna H Heflin, Carissa J Cascio
BACKGROUND: The human somatosensory system comprises dissociable paths for discriminative and affective touch, reflected in separate peripheral afferent populations and distinct cortical targets. Differences in behavioral and neural responses to affective touch may have an important developmental role in early social experiences, which are relevant for autism spectrum disorder (ASD). METHODS: Using probabilistic tractography, we compared the structural integrity of white matter pathways for discriminative and affective touch in young children with ASD and their typically developing (TD) peers...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28503904/white-matter-compromise-in-autism-differentiating-motion-confounds-from-true-differences-in-diffusion-tensor-imaging
#7
Seraphina K Solders, Ruth A Carper, Ralph-Axel Müller
Common findings from diffusion tensor imaging (DTI) in autism spectrum disorder (ASD) include reduced fractional anisotropy (FA), and increased mean and radial diffusivity (MD, RD) of white matter tracts. However, findings may be confounded by head motion. We examined how group-level motion matching affects DTI comparisons between ASD and typically developing (TD) groups. We included 57 ASD and 50 TD participants, comparing three subsets at increasing levels of motion-matching stringency: full sample (FS); quality-controlled (QC); and quantitatively-matched (QM)...
October 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28421658/transcriptional-signatures-of-connectomic-subregions-of-the-human-striatum
#8
L Parkes, B D Fulcher, M Yücel, A Fornito
Functionally distinct regions of the brain are thought to possess a characteristic connectional fingerprint - a profile of incoming and outgoing connections that defines the function of that area. This observation has motivated efforts to subdivide brain areas using their connectivity patterns. However, it remains unclear whether these connectomically-defined subregions can be distinguished at the molecular level. Here, we combine high-resolution diffusion-weighted magnetic resonance imaging with transcriptomic data to show that connectomically-defined subregions of the striatum carry distinct transcriptional signatures...
April 19, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28384486/white-matter-microstructure-in-children-with-autistic-traits
#9
Laura M E Blanken, Ryan L Muetzel, Vincent W V Jaddoe, Frank C Verhulst, Aad van der Lugt, Henning Tiemeier, Tonya White
Autism spectrum disorder (ASD) is thought to arise from aberrant development of connections in the brain. Previous studies have identified differences in white matter microstructure in children with ASD, offering support to such hypotheses. While ASD is thought to represent the severe end of a spectrum of traits, there are no studies evaluating white matter microstructure in relation to autistic traits in children from the general population. In a population-based sample of 604 6-to-10 year-old children, we assessed the relation between a continuous measure of autistic traits and white matter microstructure, using both probabilistic tractography and Tract-Based Spatial Statistics (TBSS)...
March 28, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28094463/network-over-connectivity-differentiates-autism-spectrum-disorder-from-other-developmental-disorders-in-toddlers-a-diffusion-mri-study
#10
E Conti, J Mitra, S Calderoni, K Pannek, K K Shen, A Pagnozzi, S Rose, S Mazzotti, D Scelfo, M Tosetti, F Muratori, G Cioni, A Guzzetta
Advanced connectivity studies in toddlers with Autism Spectrum Disorder (ASD) are increasing and consistently reporting a disruption of brain connectivity. However, most of these studies compare ASD and typically developing subjects, thus providing little information on the specificity of the abnormalities detected in comparison with other developmental disorders (other-DD). We recruited subjects aged below 36 months who received a clinical diagnosis of Neurodevelopmental Disorder (32 ASD and 16 other-DD including intellectual disability and language disorder) according to DSM-IV TR...
January 17, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/27630075/disorder-specific-alteration-in-white-matter-structural-property-in-adults-with-autism-spectrum-disorder-relative-to-adults-with-adhd-and-adult-controls
#11
Huey-Ling Chiang, Yu-Jen Chen, Hsiang-Yuan Lin, Wen-Yih Isaac Tseng, Susan Shur-Fen Gau
OBJECTIVE: Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are not only often comorbid but also overlapped in behavioral and cognitive abnormalities. Little is known about whether these shared phenotypes are based on common or different underlying neuropathologies. Therefore, this study aims to examine the disorder-specific alterations in white matter (WM) structural property. METHOD: The three comparison groups included 23 male adults with ASD (21...
January 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/27247853/white-and-gray-matter-fiber-pathways-in-autism-spectrum-disorder-revealed-by-ex%C3%A2-vivo-diffusion-mr-tractography
#12
Molly Wilkinson, Rongpin Wang, Andre van der Kouwe, Emi Takahashi
INTRODUCTION: The goal of this project was to study the white and gray matter brain pathways of young children with autism spectrum disorder (ASD) and investigate how ASD brains differ from those of typically developing children of the same age. METHODS: High angular resolution resolution diffusion imaging tractography and diffusion tensor imaging tractography were used to analyze the brains of two 3-year-old children with ASD and two age-matched controls. RESULTS: In the ASD brains, the callosal and corticopontine pathways were thinner overall and terminal areas in the cortical gray matter were significantly smaller...
July 2016: Brain and Behavior
https://www.readbyqxmd.com/read/27242478/reduced-volume-of-the-arcuate-fasciculus-in-adults-with-high-functioning-autism-spectrum-conditions
#13
Rachel L Moseley, Marta M Correia, Simon Baron-Cohen, Yury Shtyrov, Friedemann Pulvermüller, Bettina Mohr
Atypical language is a fundamental feature of autism spectrum conditions (ASC), but few studies have examined the structural integrity of the arcuate fasciculus, the major white matter tract connecting frontal and temporal language regions, which is usually implicated as the main transfer route used in processing linguistic information by the brain. Abnormalities in the arcuate have been reported in young children with ASC, mostly in low-functioning or non-verbal individuals, but little is known regarding the structural properties of the arcuate in adults with ASC or, in particular, in individuals with ASC who have intact language, such as those with high-functioning autism or Asperger syndrome...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27105136/similar-white-matter-but-opposite-grey-matter-changes-in-schizophrenia-and-high-functioning-autism
#14
COMPARATIVE STUDY
J Katz, M-A d'Albis, J Boisgontier, C Poupon, J-F Mangin, P Guevara, D Duclap, N Hamdani, J Petit, D Monnet, P Le Corvoisier, M Leboyer, R Delorme, J Houenou
OBJECTIVE: High-functioning autism (HFA) and schizophrenia (SZ) are two of the main neurodevelopmental disorders, sharing several clinical dimensions and risk factors. Their exact relationship is poorly understood, and few studies have directly compared both disorders. Our aim was thus to directly compare neuroanatomy of HFA and SZ using a multimodal MRI design. METHODS: We scanned 79 male adult subjects with 3T MRI (23 with HFA, 24 with SZ and 32 healthy controls, with similar non-verbal IQ)...
July 2016: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/27076697/global-and-regional-cortical-connectivity-maturation-index-ccmi-of-developmental-human-brain-with-quantification-of-short-range-association-tracts
#15
Minhui Ouyang, Tina Jeon, Virendra Mishra, Haixiao Du, Yu Wang, Yun Peng, Hao Huang
From early childhood to adulthood, synaptogenesis and synaptic pruning continuously reshape the structural architecture and neural connection in developmental human brains. Disturbance of the precisely balanced strengthening of certain axons and pruning of others may cause mental disorders such as autism and schizophrenia. To characterize this balance, we proposed a novel measurement based on cortical parcellation and diffusion MRI (dMRI) tractography, a cortical connectivity maturation index (CCMI). To evaluate the spatiotemporal sensitivity of CCMI as a potential biomarker, dMRI and T1 weighted datasets of 21 healthy subjects 2-25 years were acquired...
February 27, 2016: Proceedings of SPIE
https://www.readbyqxmd.com/read/27047349/multimodal-diffusion-mri-and-meg-assessment-of-auditory-and-language-system-development-in-autism-spectrum-disorder
#16
Jeffrey I Berman, James C Edgar, Lisa Blaskey, Emily S Kuschner, Susan E Levy, Matthew Ku, John Dell, Timothy P L Roberts
BACKGROUND: Auditory processing and language impairments are prominent in children with autism spectrum disorder (ASD). The present study integrated diffusion MR measures of white-matter microstructure and magnetoencephalography (MEG) measures of cortical dynamics to investigate associations between brain structure and function within auditory and language systems in ASD. Based on previous findings, abnormal structure-function relationships in auditory and language systems in ASD were hypothesized...
2016: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/26912520/frontal-networks-in-adults-with-autism-spectrum-disorder
#17
Marco Catani, Flavio Dell'Acqua, Sanja Budisavljevic, Henrietta Howells, Michel Thiebaut de Schotten, Seán Froudist-Walsh, Lucio D'Anna, Abigail Thompson, Stefano Sandrone, Edward T Bullmore, John Suckling, Simon Baron-Cohen, Michael V Lombardo, Sally J Wheelwright, Bhismadev Chakrabarti, Meng-Chuan Lai, Amber N V Ruigrok, Alexander Leemans, Christine Ecker, Mrc Aims Consortium, Michael C Craig, Declan G M Murphy
It has been postulated that autism spectrum disorder is underpinned by an 'atypical connectivity' involving higher-order association brain regions. To test this hypothesis in a large cohort of adults with autism spectrum disorder we compared the white matter networks of 61 adult males with autism spectrum disorder and 61 neurotypical controls, using two complementary approaches to diffusion tensor magnetic resonance imaging. First, we applied tract-based spatial statistics, a 'whole brain' non-hypothesis driven method, to identify differences in white matter networks in adults with autism spectrum disorder...
February 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/26677408/abnormal-wiring-of-the-connectome-in-adults-with-high-functioning-autism-spectrum-disorder
#18
Ulrika Roine, Timo Roine, Juha Salmi, Taina Nieminen-von Wendt, Pekka Tani, Sami Leppämäki, Pertti Rintahaka, Karen Caeyenberghs, Alexander Leemans, Mikko Sams
BACKGROUND: Recent brain imaging findings suggest that there are widely distributed abnormalities affecting the brain connectivity in individuals with autism spectrum disorder (ASD). Using graph theoretical analysis, it is possible to investigate both global and local properties of brain's wiring diagram, i.e., the connectome. METHODS: We acquired diffusion-weighted magnetic resonance imaging data from 14 adult males with high-functioning ASD and 19 age-, gender-, and IQ-matched controls...
2015: Molecular Autism
https://www.readbyqxmd.com/read/26493162/regional-specificity-of-aberrant-thalamocortical-connectivity-in-autism
#19
Aarti Nair, Ruth A Carper, Angela E Abbott, Colleen P Chen, Seraphina Solders, Sarah Nakutin, Michael C Datko, Inna Fishman, Ralph-Axel Müller
Preliminary evidence suggests aberrant (mostly reduced) thalamocortical (TC) connectivity in autism spectrum disorder (ASD), but despite the crucial role of thalamus in sensorimotor functions and its extensive connectivity with cerebral cortex, relevant evidence remains limited. We performed a comprehensive investigation of region-specific TC connectivity in ASD. Resting-state functional MRI and diffusion tensor imaging (DTI) data were acquired for 60 children and adolescents with ASD (ages 7-17 years) and 45 age, sex, and IQ-matched typically developing (TD) participants...
November 2015: Human Brain Mapping
https://www.readbyqxmd.com/read/26446271/high-angular-resolution-diffusion-imaging-in-a-child-with-autism-spectrum-disorder-and-comparison-with-his-unaffected-identical-twin
#20
Eugenia Conti, Kerstin Pannek, Sara Calderoni, Anna Gaglianese, Simona Fiori, Paola Brovedani, Danilo Scelfo, Stephen Rose, Michela Tosetti, Giovanni Cioni, Andrea Guzzetta
In recent years, the use of brain diffusion MRI has led to the hypothesis that children with autism spectrum disorder (ASD) show abnormally connected brains. We used the model of disease-discordant identical twins to test the hypothesis that higher-order diffusion MRI protocols are able to detect abnormal connectivity in a single subject. We studied the structural connectivity of the brain of a child with ASD, and of that of his unaffected identical twin, using high angular resolution diffusion imaging (HARDI) probabilistic tractography...
July 2015: Functional Neurology
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