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https://www.readbyqxmd.com/read/29148202/common-paediatric-conditions-of-the-lower-limb
#1
REVIEW
Ashlee M Dobbe, Paul J Gibbons
Growing children are susceptible to a number of disorders to their lower extremities of varying degrees of severity. The diagnosis and management of these conditions can be challenging. With musculoskeletal symptoms being one of the leading reasons for visits to general practitioners, a working knowledge of the basics of these disorders can help in the appropriate diagnosis, treatment, counselling, and specialist referral. This review covers common disorders affecting the hip, the knee and the foot. The aim is to assist general practitioners in recognising developmental norms and differentiating physiological from pathological conditions and to identify when a specialist referral is necessary...
November 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29143417/can-antarctic-lichens-acclimatise-to-changes-in-temperature
#2
Claudia Colesie, Burkhard Büdel, Vaughan Hurry, T G Allan Green
The Antarctic Peninsula, a tundra biome dominated by lichens and bryophytes, is an ecozone undergoing rapid temperature shifts. Such changes may demand a high physiological plasticity of the local lichen species in order for them to maintain their role as key drivers in this pristine habitat. This study examines the response of net photosynthesis and respiration to increasing temperatures for three Antarctic lichen species with different ecological response amplitudes. We hypothesise that negative effects caused by increased temperatures can be mitigated by thermal acclimation of respiration and/or photosynthesis...
November 15, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29142788/a-unified-approach-to-model-peripheral-nerves-across-different-animal-species
#3
Elisabetta Giannessi, Maria Rita Stornelli, Pier Nicola Sergi
Peripheral nerves are extremely complex biological structures. The knowledge of their response to stretch is crucial to better understand physiological and pathological states (e.g., due to overstretch). Since their mechanical response is deterministically related to the nature of the external stimuli, theoretical and computational tools were used to investigate their behaviour. In this work, a Yeoh-like polynomial strain energy function was used to reproduce the response of in vitro porcine nerve. Moreover, this approach was applied to different nervous structures coming from different animal species (rabbit, lobster, Aplysia) and tested for different amount of stretch (up to extreme ones)...
2017: PeerJ
https://www.readbyqxmd.com/read/29138675/benign-effect-of-extremely-low-frequency-electromagnetic-field-on-brain-plasticity-assessed-by-nitric-oxide-metabolism-during-poststroke-rehabilitation
#4
Natalia Cichoń, Piotr Czarny, Michał Bijak, Elżbieta Miller, Tomasz Śliwiński, Janusz Szemraj, Joanna Saluk-Bijak
Nitric oxide (NO) is one of the most important signal molecules, involved in both physiological and pathological processes. As a neurotransmitter in the central nervous system, NO regulates cerebral blood flow, neurogenesis, and synaptic plasticity. The aim of our study was to investigate the effect of the extremely low-frequency electromagnetic field (ELF-EMF) on generation and metabolism of NO, as a neurotransmitter, in the rehabilitation of poststroke patients. Forty-eight patients were divided into two groups: ELF-EMF and non-ELF-EMF...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29138031/mortality-and-pulmonary-outcomes-of-extremely-preterm-infants-exposed-to-antenatal-corticosteroids
#5
Colm P Travers, Waldemar A Carlo, Scott A Mcdonald, Abhik Das, Edward F Bell, Namasivayam Ambalavanan, Alan H Jobe, Ronald N Goldberg, Carl T D'Angio, Barbara J Stoll, Seetha Shankaran, Abbot R Laptook, Barbara Schmidt, Michele C Walsh, Pablo J Sanchez, M Bethany Ball, Ellen C Hale, Nancy S Newman, Rosemary D Higgins
BACKGROUND: Antenatal corticosteroids are given primarily to induce fetal lung maturation but results from meta-analyses of randomized controlled trials have not shown mortality or pulmonary benefits for extremely preterm infants although these are the infants most at risk of mortality and pulmonary disease. OBJECTIVE: To determine if exposure to antenatal corticosteroids is associated with a lower rate of death and pulmonary morbidities by 36 weeks' postmenstrual age...
November 11, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29137985/the-effect-of-surface-charge-on-the-thermal-stability-and-ice-recrystallization-inhibition-activity-of-antifreeze-protein-iii-afp-iii
#6
R C Deller, B M Carter, I Zampetakis, F Scarpa, A W Perriman
The aim of this study was to examine the effect of chemical cationization on the structure and function of antifreeze protein III (AFP III) over an extreme temperature range (-40 °C to +90 °C) using far-UV synchrotron radiation circular dichroism (SRCD) and ice recrystallization inhibition (IRI) assays. Chemical cationization was able to produce a modified AFP III with a net cationic charge at physiological pH that had enhanced resistance to denaturation at elevated temperatures, with no immediate negative impact on protein structure at subzero temperatures...
November 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29136391/effects-of-1-h-16-o-charged-particle-irradiation-on-short-term-memory-and-hippocampal-physiology-in-a-murine-model
#7
Frederico Kiffer, Hannah Carr, Thomas Groves, Julie E Anderson, Tyler Alexander, Jing Wang, John W Seawright, Vijayalakshmi Sridharan, Gwendolyn Carter, Marjan Boerma, Antiño R Allen
Radiation from galactic cosmic rays (GCR) poses a significant health risk for deep-space flight crews. GCR are unique in their extremely high-energy particles. With current spacecraft shielding technology, some of the predominant particles astronauts would be exposed to are (1)H + (16)O. Radiation has been shown to cause cognitive deficits in mice. The hippocampus plays a key role in memory and cognitive tasks; it receives information from the cortex, undergoes dendritic-dependent processing and then relays information back to the cortex...
November 14, 2017: Radiation Research
https://www.readbyqxmd.com/read/29133414/correlating-kinetic-and-structural-data-on-ubiquinone-binding-and-reduction-by-respiratory-complex-i
#8
Justin G Fedor, Andrew J Y Jones, Andrea Di Luca, Ville R I Kaila, Judy Hirst
Respiratory complex I (NADH:ubiquinone oxidoreductase), one of the largest membrane-bound enzymes in mammalian cells, powers ATP synthesis by using the energy from electron transfer from NADH to ubiquinone-10 to drive protons across the energy-transducing mitochondrial inner membrane. Ubiquinone-10 is extremely hydrophobic, but in complex I the binding site for its redox-active quinone headgroup is ∼20 Å above the membrane surface. Structural data suggest it accesses the site by a narrow channel, long enough to accommodate almost all of its ∼50-Å isoprenoid chain...
November 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29130570/cold-water-or-partial-body-cryotherapy-comparison-of-physiological-responses-and-recovery-following-muscle-damage
#9
Erich Hohenauer, Joseph T Costello, Rahel Stoop, Ursula M Küng, Peter Clarys, Tom Deliens, Ron Clijsen
The aim of this study was to compare i) the physiological responses following cold-water immersion (CWI) and partial-body cryotherapy (PBC) and ii) the effects on recovery following a muscle-damaging protocol (5 x 20 drop jumps). Nineteen healthy males were randomly allocated into either a CWI (10 °C for 10 min; n = 9) or a PBC (-60 °C for 30 sec, -135 °C for 2 min; n = 10) group. The physiological variables (thigh muscle oxygen saturation [SmO2 ], cutaneous vascular conductance [CVC], mean-arterial pressure [MAP] and local skin temperature) were assessed immediately prior and up to 60 min post-treatment (10 min intervals)...
November 11, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29128981/what-to-eat-in-a-warming-world-do-increased-temperatures-necessitate-hazardous-duty-pay
#10
L Embere Hall, Anna D Chalfoun
Contemporary climate change affects nearly all biomes, causing shifts in animal distributions and resource availability. Changes in resource selection may allow individuals to offset climatic stress, thereby providing a mechanism for persistence amidst warming conditions. Whereas the role of predation risk in food choice has been studied broadly, the extent to which individuals respond to thermoregulatory risk by changing resource preferences is unclear. We addressed whether individuals compensated for temperature-related reductions in foraging time by altering forage preferences, using the American pika (Ochotona princeps) as a model species...
November 11, 2017: Oecologia
https://www.readbyqxmd.com/read/29127487/towards-a-unified-understanding-of-lithium-action-in-basic-biology-and-its-significance-for-applied-biology
#11
REVIEW
Eric Jakobsson, Orlando Argüello-Miranda, See-Wing Chiu, Zeeshan Fazal, James Kruczek, Santiago Nunez-Corrales, Sagar Pandit, Laura Pritchet
Lithium has literally been everywhere forever, since it is one of the three elements created in the Big Bang. Lithium concentration in rocks, soil, and fresh water is highly variable from place to place, and has varied widely in specific regions over evolutionary and geologic time. The biological effects of lithium are many and varied. Based on experiments in which animals are deprived of lithium, lithium is an essential nutrient. At the other extreme, at lithium ingestion sufficient to raise blood concentration significantly over 1 mM/, lithium is acutely toxic...
November 10, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29126967/effects-of-temperature-and-salinity-on-prevalence-and-intensity-of-infection-of-blue-crabs-callinectes-sapidus-by-vibrio-cholerae-v-parahaemolyticus-and-v-vulnificus-in-louisiana
#12
Timothy J Sullivan, Joseph E Neigel
Coastal marine and estuarine environments are experiencing higher average temperatures, greater frequency of extreme temperature events, and altered salinities. These changes are expected to stress organisms and increase their susceptibility to infectious diseases. However, beyond these generalities, little is known about how environmental factors influence host-pathogen relationships in the marine realm. We investigated the prevalence and intensity of infections by Vibrio cholerae, V. parahaemolyticus, and V...
November 7, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/29123391/surface-enhanced-raman-scattering-investigation-of-targeted-delivery-and-controlled-release-of-gemcitabine
#13
Ty Santiago, Rebecca Sinnott DeVaux, Katarzyna Kurzatkowska, Ricardo Espinal, Jason I Herschkowitz, Maria Hepel
Advanced and metastatic cancer forms are extremely difficult to treat and require high doses of chemotherapeutics, inadvertently affecting also healthy cells. As a result, the observed survival rates are very low. For instance, gemcitabine (GEM), one of the most effective chemotherapeutic drugs used for the treatment of breast and pancreatic cancers, sees only a 20% efficacy in penetrating cancer tissue, resulting in <5% survival rate in pancreatic cancer. Here, we present a method for delivering the drug that offers mitigation of side effects, as well as a targeted delivery and controlled release of the drug, improving its overall efficacy...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29122957/diminished-dynamic-cerebral-autoregulatory-capacity-with-forced-oscillations-in-mean-arterial-pressure-with-elevated-cardiorespiratory-fitness
#14
Lawrence Labrecque, Kevan Rahimaly, Sarah Imhoff, Myriam Paquette, Olivier Le Blanc, Simon Malenfant, Samuel J E Lucas, Damian M Bailey, Jonathan D Smirl, Patrice Brassard
The effect that cardiorespiratory fitness has on the dynamic cerebral autoregulatory capacity during changes in mean arterial pressure (MAP) remains equivocal. Using a multiple-metrics approach, challenging MAP across the spectrum of physiological extremes (i.e., spontaneous through forced MAP oscillations), we characterized dynamic cerebral autoregulatory capacity in 19 male endurance athletes and eight controls via three methods: (1) onset of regulation (i.e., time delay before an increase in middle cerebral artery (MCA) conductance [MCA blood velocity (MCAv)/MAP] and rate of regulation, after transient hypotension induced by sit-to-stand, and transfer function analysis (TFA) of MAP and MCAv responses during (2) spontaneous and (3) forced oscillations (5-min of squat-stand maneuvers performed at 0...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29122728/comparative-proteomics-and-codon-substitution-analysis-reveal-mechanisms-of-differential-resistance-to-hypoxia-in-congeneric-snails
#15
Huawei Mu, Jin Sun, Siu Gin Cheung, Ling Fang, Haiyun Zhou, Tiangang Luan, Huoming Zhang, Chris K C Wong, Jian-Wen Qiu
Although high-throughput proteomics has been widely applied to study mechanisms of environmental adaptation, the conclusions from studies that are based on one species can be confounded by phylogeny. We compare the freshwater snail Pomacea canaliculata (a notorious invasive species) and its congener Pomacea diffusa (a non-invasive species) to understand the molecular mechanisms of their differential resistance to hypoxia. A 72-h acute exposure experiment showed that P. canaliculata is more tolerant to hypoxia than P...
November 6, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/29119738/physiological-characterization-transcriptomic-profiling-and-microsatellite-marker-mining-of-lycium-ruthenicum
#16
Jin-Huan Chen, Dong-Zhi Zhang, Chong Zhang, Mei-Long Xu, Wei-Lun Yin
Lycium ruthenicum is a perennial shrub species that has attracted considerable interest in recent years owing to its nutritional value and ability to thrive in a harsh environment. However, only extremely limited transcriptomic and genomic data related to this species can be found in public databases, thereby limiting breeding research and molecular function analysis. In this study, we characterized the physiological and biochemical responses to saline-alkaline mixed stress by measuring photochemical efficiency, chlorophyll content, and protective enzyme activity...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/29118107/morphological-constraints-on-cerebellar-granule-cell-combinatorial-diversity
#17
Jesse I Gilmer, Abigail L Person
Combinatorial expansion by the cerebellar granule cell layer (GCL) is fundamental to theories of cerebellar contributions to motor control and learning. Granule cells sample approximately four mossy fiber inputs and are thought to form a combinatorial code useful for pattern separation and learning. We constructed a spatially realistic model of the cerebellar granule cell layer and examined how GCL architecture contributes to granule cell (GrC) combinatorial diversity. We found that GrC combinatorial diversity saturates quickly as mossy fiber input diversity increases, and that this saturation is in part a consequence of short dendrites, which limit access to diverse inputs and favor dense sampling of local inputs...
November 8, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29117754/generation-and-characterization-of-new-alleles-of-quiver-qvr-that-encodes-an-extracellular-modulator-of-the-shaker-potassium-channel
#18
Hongyu Ruan, Atsushi Ueda, Xiaomin Xing, Xuxuan Wan, Benjamin Strub, Spencer Mukai, Kaan Certel, David Green, Kyle Belozerov, Wei-Dong Yao, Wayne Johnson, Jim Jung-Ching Lin, Arthur J Hilliker, Chun-Fang Wu
Our earlier genetic screen uncovered a paraquat-sensitive leg-shaking mutant quiver(1) (qvr(1)), whose gene product interacts with the Shaker (Sh) K(+) channel. We also mapped the qvr locus to EY04063 and noticed altered day-night activity patterns in these mutants. Such circadian behavioral defects were independently reported by another group, who employed the qvr(1) allele we supplied them, and attributed the extreme restless phenotype of EY04063 to the qvr gene. However, their report adopted a new noncanonical gene name sleepless (sss) for qvr...
November 9, 2017: Journal of Neurogenetics
https://www.readbyqxmd.com/read/29114390/phospholipase-d-inhibition-by-hexanal-is-associated-with-calcium-signal-transduction-events-in-raspberry
#19
Walid El Kayal, Gopinadhan Paliyath, J Alan Sullivan, Jayasankar Subramanian
Raspberry (Rubus spp.) is an economically important crop with a restricted growing season and very limited fruit shelf-life due to its extreme tenderness. In order to prolong its shelf life, an aqueous composition containing hexanal as the key active ingredient (HC) was applied as a preharvest spray during fruit development. The effects of HC were assessed using physiological, biochemical and anatomical parameters on the treated fruits and compared with the effects of mock inoculation which lacked hexanal. Sugars and acidity did not show a significant change in response to HC treatment, while the pulling force (the tension required to detach the berry from the receptacle) significantly improved in the HC-treated fruits, compared to control...
2017: Horticulture Research
https://www.readbyqxmd.com/read/29113989/cold-hearted-bats-uncoupling-of-heart-rate-and-metabolism-during-torpor-at-subzero-temperatures
#20
Shannon E Currie, Clare Stawski, Fritz Geiser
Many hibernating animals thermoregulate during torpor and defend their body temperature (Tb) below 10°C by an increase in metabolic rate. Above a critical temperature (Tcrit) animals usually thermoconform. We investigated the physiological responses above and below Tcrit for a small tree dwelling bat (Chalinolobus gouldii, ∼14 g) that is often exposed to subzero temperatures during winter. Through simultaneous measurement of heart rate (HR) and oxygen consumption (V̇O2) we show that the relationship between oxygen transport and cardiac function is substantially altered in thermoregulating torpid bats between 1 and -2°C, compared with thermoconforming torpid bats at mild ambient temperatures (Ta 5-20°C)...
November 7, 2017: Journal of Experimental Biology
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