keyword
MENU ▼
Read by QxMD icon Read
search

Helical heart

keyword
https://www.readbyqxmd.com/read/28691076/self-assembling-cyclic-d-l-%C3%AE-peptides-as-modulators-of-plasma-hdl-function-a-supramolecular-approach-toward-antiatherosclerotic-agents
#1
Yannan Zhao, Luke J Leman, Debra J Search, Ricardo A Garcia, David A Gordon, Bruce E Maryanoff, M Reza Ghadiri
There is great interest in developing new modes of therapy for atherosclerosis to treat coronary heart disease and stroke, particularly ones that involve modulation of high-density lipoproteins (HDLs). Here, we describe a new supramolecular chemotype for altering HDL morphology and function. Guided by rational design and SAR-driven peptide sequence enumerations, we have synthesized and determined the HDL remodeling activities of over 80 cyclic d,l-α-peptides. We have identified a few distinct sequence motifs that are effective in vitro in remodeling human and mouse plasma HDLs to increase the concentration of lipid-poor pre-beta HDLs, which are key initial acceptors of cholesterol in the reverse cholesterol transport (RCT) process, and concomitantly promote cholesterol efflux from macrophage cells...
June 28, 2017: ACS Central Science
https://www.readbyqxmd.com/read/28675658/spectroscopic-study-of-the-interaction-between-horse-heart-myoglobin-and-zr-iv-substituted-polyoxometalates-as-artificial-proteases
#2
Tatjana N Parac-Vogt, Hong GiangHong Giang Thi Ly
Our recent study (Angew. Chem. Int. Ed. 2015, 54, 7391-7394) has shown that Horse heart myoglobin (HHM) was selectively hydrolyzed by a range of Zr(IV)-substituted polyoxometalates (POMs) under mild conditions. In this study the molecular interactions between the Zr-POM catalysts and HHM were investigated by using a range of complementary techniques that include circular dichroism (CD), UV-Vis spectroscopy, tryptophan fluorescence spectroscopy, 1H NMR and 31P NMR spectroscopy. Trp fluorescence quenching study revealed that among all examined Zr-POMs, the most reactive POM, 2:2 Zr(IV)-Keggin, exhibited the strongest interaction with HHM...
July 4, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28663827/heart-structural-remodeling-in-a-mouse-model-of-duchenne-cardiomyopathy-revealed-using-optical-polarization-tractography-invited
#3
Y Wang, K Zhang, D Duan, G Yao
We investigated the heart structural remodeling in the mdx4cv mouse model of Duchenne cardiomyopathy using optical polarization tractography. Whole heart tractography was obtained in freshly dissected hearts from six mdx4cv mice. Six hearts from C57BL/6J mice were also imaged as the normal control. The mdx4cv hearts were significantly larger than the control hearts and had significantly higher between-subject variations in myofiber organization. While both strains showed classic cross-helical fiber organization in the left ventricle, the rate of the myocardial fiber orientation change across the heart wall was significantly altered in the right ventricle of the mdx4cv heart...
March 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28594468/application-of-an-advanced-maximum-likelihood-estimation-restoration-method-for-enhanced-resolution-and-contrast-in-second-harmonic-generation-microscopy
#4
Mayandi Sivaguru, Mohammad M Kabir, Manas Rangan Gartia, David S C Biggs, Barghav S Sivaguru, Vignesh A Sivaguru, Glenn A Fried, Gang Logan Liu, Sakthivel Sadayappan, Kimani C Toussaint
Second-harmonic generation (SHG) microscopy has gained popularity because of its ability to perform submicron, label-free imaging of noncentrosymmetric biological structures, such as fibrillar collagen in the extracellular matrix environment of various organs with high contrast and specificity. Because SHG is a two-photon coherent scattering process, it is difficult to define a point spread function (PSF) for this modality. Hence, compared to incoherent two-photon processes like two-photon fluorescence, it is challenging to apply the various PSF-engineering methods to improve the spatial resolution to be close to the diffraction limit...
June 8, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28593869/a-mock-heart-engineered-with-helical-aramid-fibers-for-in-vitro-cardiovascular-device-testing
#5
So-Hyun Jansen-Park, Po-Lin Hsu, Indra Müller, Ulrich Steinseifer, Dirk Abel, Rüdiger Autschbach, Rolf Rossaint, Thomas Schmitz-Rode
Mock heart circulation loops (MHCLs) serve as in-vitro platforms to investigate the physiological interaction between circulatory systems and cardiovascular devices. A mock heart (MH) engineered with silicone walls and helical aramid fibers, to mimic the complex contraction of a natural heart, has been developed to advance the MHCL previously developed in our group. A mock aorta with an anatomical shape enables the evaluation of a cannulation method for ventricular assist devices (VADs) and investigation of the usage of clinical measurement systems like pressure-volume catheters...
April 4, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28539564/improvement-of-local-cell-delivery-using-helix-transendocardial-delivery-catheter-in-a-porcine-heart
#6
Yoshiaki Mitsutake, Wook Bum Pyun, Didier Rouy, Cheryl Wong Po Foo, Simon H Stertzer, Peter Altman, Fumiaki Ikeno
Cardiac regeneration strategies using stem cells have shown variable and inconsistent results with respect to patient cardiac function and clinical outcomes. There has been increasing consensus that improving the efficiency of delivery may improve results. The Helix transendocardial delivery system (BioCardia Inc.) has been developed to enable percutaneous transendocardial biotherapeutic delivery. Therefore, we evaluated cell retention using this unique system compared with direct transepicardial injection and intracoronary infusion in an animal model...
May 23, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28536896/helical-distribution-of-hypertrophy-in-patients-with-hypertrophic-cardiomyopathy-prevalence-and-clinical-implications
#7
Dafne Viliani, Eduardo Pozo, Norma Aguirre, Alberto Cecconi, María J Olivera, Paloma Caballero, Luis J Jiménez-Borreguero, Fernando Alfonso
Recently a novel pattern of helical distribution of hypertrophy has been described in patients with hypertrophic cardiomyopathy (HCM). Our aim was to determine its prevalence and potential implications in an unselected cohort. One-hundred- and eight consecutive patients diagnosed with HCM by cardiac magnetic resonance (CMR) were included (median clinical follow up of 1718 days). All clinical and complementary test information was prospectively collected. The presence of a helical pattern was assessed by a simple measurement of the maximal left ventricle (LV) wall thickness (LVWT) for each of the 17 classical LV segments and it was classified in one of three types according to its extension...
May 23, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28487672/the-g-protein-coupled-receptor-ut-of-the-neuropeptide-urotensin-ii-displays-structural-and-functional-chemokine-features
#8
REVIEW
Hélène Castel, Laurence Desrues, Jane-Eileen Joubert, Marie-Christine Tonon, Laurent Prézeau, Marie Chabbert, Fabrice Morin, Pierrick Gandolfo
The urotensinergic system was previously considered as being linked to numerous physiopathological states, including atherosclerosis, heart failure, hypertension, pre-eclampsia, diabetes, renal disease, as well as brain vascular lesions. Thus, it turns out that the actions of the urotensin II (UII)/G protein-coupled receptor UT system in animal models are currently not predictive enough in regard to their effects in human clinical trials and that UII analogs, established to target UT, were not as beneficial as expected in pathological situations...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28469512/does-motion-assessment-with-4-dimensional-computed-tomographic-imaging-for-non-small-cell-lung-cancer-radiotherapy-improve-target-volume-coverage
#9
Naseer Ahmed, Sankar Venkataraman, Kate Johnson, Keith Sutherland, Shaun K Loewen
INTRODUCTION: Modern radiotherapy with 4-dimensional computed tomographic (4D-CT) image acquisition for non-small cell lung cancer (NSCLC) captures respiratory-mediated tumor motion to provide more accurate target delineation. This study compares conventional 3-dimensional (3D) conformal radiotherapy (3DCRT) plans generated with standard helical free-breathing CT (FBCT) with plans generated on 4D-CT contoured volumes to determine whether target volume coverage is affected. MATERIALS AND METHODS: Fifteen patients with stage I to IV NSCLC were enrolled in the study...
2017: Clinical Medicine Insights. Oncology
https://www.readbyqxmd.com/read/28398210/out-of-field-doses-from-pediatric-craniospinal-irradiations-using-3d-crt-imrt-helical-tomotherapy-and-electron-based-therapy
#10
Marijke De Saint-Hubert, Dirk Verellen, Kenneth Poels, Wouter Crijns, Federica Magliona, Tom Depuydt, Filip Vanhavere, Lara Struelens
Medulloblastoma treatment involves irradiation of the entire central nervous system, i.e. craniospinal irradiation (CSI). This is associated with the significant exposure of large volumes of healthy tissue and there is growing concern regarding treatment-associated side effects. The current study compares out-of-field organ doses in children receiving CSI through 3D-conformal radiotherapy (3D-CRT), intensity modulated radiotherapy (IMRT), helical tomotherapy (HT) and an electron-based technique, and includes radiation doses resulting from imaging performed during treatment...
July 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28375841/a-mock-heart-engineered-with-helical-aramid-fibers-for-in-vitro-cardiovascular-device-testing
#11
So-Hyun Jansen-Park, Po-Lin Hsu, Indra Müller, Ulrich Steinseifer, Dirk Abel, Rüdiger Autschbach, Rolf Rossaint, Thomas Schmitz-Rode
Mock heart circulation loops (MHCLs) serve as in-vitro platforms to investigate the physiological interaction between circulatory systems and cardiovascular devices. A mock heart (MH) engineered with silicone walls and helical aramid fibers, to mimic the complex contraction of a natural heart, has been developed to advance the MHCL previously developed in our group. A mock aorta with an anatomical shape enables the evaluation of a cannulation method for ventricular assist devices (VADs) and investigation of the usage of clinical measurement systems like pressure-volume catheters...
April 1, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28297441/comprehensive-dosimetric-planning-comparison-for-early-stage-non-small-cell-lung-cancer-with-sabr-fixed-beam-imrt-versus-vmat-versus-tomotherapy
#12
Ilma Xhaferllari, Omar El-Sherif, Stewart Gaede
Volumetric-modulated arc therapy (VMAT) is emerging as a leading technology in treating early-stage, non-small cell lung cancer (NSCLC) with stereotactic ablative radiotherapy (SABR). However, two other modalities capable of delivering intensity-modulated radiation therapy (IMRT) include fixed-beam and helical TomoTherapy (HT). This study aims to provide an extensive dosimetric comparison among these various IMRT techniques for treating early-stage NSCLC with SABR. Ten early-stage NSCLC patients were retrospectively optimized using three fixed-beam techniques via nine to eleven beams (high and low modulation step-and-shoot (SS), and sliding window (SW)), two VMAT techniques via two partial arcs (SmartArc (SA) and RapidArc (RA)), and three HT techniques via three different fan beam widths (1 cm, 2...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28295788/creating-hemodynamic-atlases-of-cardiac-4d-flow-mri
#13
Merih Cibis, Mariana Bustamante, Jonatan Eriksson, Carl-Johan Carlhäll, Tino Ebbers
PURPOSE: Hemodynamic atlases can add to the pathophysiological understanding of cardiac diseases. This study proposes a method to create hemodynamic atlases using 4D Flow magnetic resonance imaging (MRI). The method is demonstrated for kinetic energy (KE) and helicity density (Hd ). MATERIALS AND METHODS: Thirteen healthy subjects underwent 4D Flow MRI at 3T. Phase-contrast magnetic resonance cardioangiographies (PC-MRCAs) and an average heart were created and segmented...
March 13, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28282389/4d-flow-mri-assessment-of-right-atrial-flow-patterns-in-the-normal-heart-influence-of-caval-vein-arrangement-and-implications-for-the-patent-foramen-ovale
#14
Jehill D Parikh, Jayant Kakarla, Bernard Keavney, John J O'Sullivan, Gary A Ford, Andrew M Blamire, Kieren G Hollingsworth, Louise Coats
AIM: To investigate atrial flow patterns in the normal adult heart, to explore whether caval vein arrangement and patency of the foramen ovale (PFO) may be associated with flow pattern. MATERIALS AND METHODS: Time-resolved, three-dimensional velocity encoded magnetic resonance imaging (4D flow) was employed to assess atrial flow patterns in thirteen healthy subjects (6 male, 40 years, range 25-50) and thirteen subjects (6 male, 40 years, range 21-50) with cryptogenic stroke and patent foramen ovale (CS-PFO)...
2017: PloS One
https://www.readbyqxmd.com/read/28268951/interventional-placement-of-thin-coil-shaped-implants-powered-wirelessly-for-monitoring-vital-signals-and-controlling-abnormal-activities-by-electro-stimulation
#15
Hidetoshi Ohta, Masanobu Honda, Makoto Takamiya
Various types of implants are being commonly used for monitoring vital signals and controlling the critically ill patient's condition such as arrhythmia, sick sinus syndrome, etc. For implanting these medical devices under the skin, surgery is inevitable. These days many patients are more willing to accept interventional therapies that are less invasive, especially inserting a catheter into a blood vessel or endoscopy through a natural orifice. To be able to use interventional therapy for implanting medical devices, they will need to be small enough to fit them through a catheter or the forceps channel of an endoscope...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28249288/responsiveness-of-coronary-arteries-to-nitroglycerin-under-hypoxia-the-importance-of-the-endothelium
#16
Masashi Tawa, Takashi Shimosato, Hiroshi Sakonjo, Tomio Okamura
BACKGROUND/AIMS: Nitroglycerin is widely used as a coronary vasodilator in the treatment of ischemic heart diseases. This study investigated the influence of hypoxia on nitroglycerin-induced relaxation in endothelium-intact and -denuded rabbit, monkey, and porcine coronary arteries. METHODS: Helically cut strips of coronary arteries were suspended in organ chambers, and isometric tension was recorded. RESULTS: Nitroglycerin concentration dependently relaxed endothelium-intact rabbit coronary arteries, which were not different under normoxic and hypoxic conditions...
2017: Pharmacology
https://www.readbyqxmd.com/read/28245984/conformational-and-thermal-characterization-of-left-ventricle-remodeling-post-myocardial-infarction
#17
V Samouillan, E Revuelta-López, C Soler-Botija, J Dandurand, Aleyda Benitez-Amaro, L Nasarre, D de Gonzalo-Calvo, A Bayes-Genis, C Lacabanne, V Llorente-Cortés
Adverse cardiac remodeling after myocardial infarction (MI) causes impaired ventricular function and heart failure. Histopathological characterization is commonly used to detect the location, size and shape of MI sites. However, the information about chemical composition, physical structure and molecular mobility of peri- and infarct zones post-MI is rather limited. The main objective of this work was to explore the spatiotemporal biochemical and biophysical alterations of key cardiac components post-MI. The FTIR spectra of healthy and remote myocardial tissue shows amides A, I, II and III associated with proteins in freeze-died tissue as major absorptions bands...
February 27, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28227158/interventional-placement-of-thin-coil-shaped-implants-powered-wirelessly-for-monitoring-vital-signals-and-controlling-abnormal-activities-by-electro-stimulation
#18
Hidetoshi Ohta, Masanobu Honda, Makoto Takamiya, Hidetoshi Ohta, Masanobu Honda, Makoto Takamiya, Masanobu Honda, Hidetoshi Ohta, Makoto Takamiya
Various types of implants are being commonly used for monitoring vital signals and controlling the critically ill patient's condition such as arrhythmia, sick sinus syndrome, etc. For implanting these medical devices under the skin, surgery is inevitable. These days many patients are more willing to accept interventional therapies that are less invasive, especially inserting a catheter into a blood vessel or endoscopy through a natural orifice. To be able to use interventional therapy for implanting medical devices, they will need to be small enough to fit them through a catheter or the forceps channel of an endoscope...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28217410/design-and-analysis-of-a-field-modulated-magnetic-screw-for-artificial-heart
#19
Zhijian Ling, Jinghua Ji, Fangqun Wang, Fangfang Bian
This paper proposes a new electromechanical energy conversion system, called Field Modulated Magnetic Screw (FMMS) as a high force density linear actuator for artificial heart. This device is based on the concept of magnetic screw and linear magnetic gear. The proposed FMMS consists of three parts with the outer and inner carrying the radially magnetized helically permanent-magnet (PM), and the intermediate having a set of helically ferromagnetic pole pieces, which modulate the magnetic fields produced by the PMs...
May 2017: AIP Advances
https://www.readbyqxmd.com/read/28199087/expression-purification-and-properties-of-a-human-arachidonoyl-specific-isoform-of-diacylglycerol-kinase
#20
William Jennings, Sejal Doshi, Prasanta Kumar Hota, Aaron Prodeus, Stephanie Black, Richard M Epand
Diacylglycerol kinase ε (DGKε) catalyzes the phosphorylation of diacylglycerol, producing phosphatidic acid. DGKε demonstrates exquisite specificity for the acyl chains of diacylglycerol. This contributes to the enrichment of particular acyl chains within the lipids of the phosphatidylinositol cycle. Phosphatidylinositol is highly enriched with 1-stearoyl-2-arachidonoyl, which is important for maintaining cellular health. Dysregulation of DGKε perturbs lipid signaling and biosynthesis, which has been linked to epilepsy, Huntington's disease, and heart disease...
March 7, 2017: Biochemistry
keyword
keyword
45604
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"