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https://www.readbyqxmd.com/read/29755629/interventricular-vessel-of-the-heart
#1
Pekka J Kuusela
The communication from right to left through the interventricular septum of the heart became identified by the anatomical study for 4 years. One thousand nine hundred years ago, Galen stated that blood seeps through the perforations in the interventricular septum of the heart. However, William Harvey, working 400 years ago, failed to find any. The interventricular vessel is a slit between the fibers of the muscle feasible to be patent by relaxing and widening of the helical heart at the right atrial filling phase at the end of the diastole...
April 2018: Cardiology Research
https://www.readbyqxmd.com/read/29739328/a-novel-ultrafast-low-dose-computed-tomography-protocol-allows-concomitant-coronary-artery-evaluation-and-lung-cancer-screening
#2
Carlo Gaudio, Gennaro Petriello, Francesco Pelliccia, Alessandra Tanzilli, Alberto Bandiera, Gaetano Tanzilli, Francesco Barillà, Vincenzo Paravati, Massimo Pellegrini, Enrico Mangieri, Paolo Barillari
BACKGROUND: Cardiac computed tomography (CT) is often performed in patients who are at high risk for lung cancer in whom screening is currently recommended. We tested diagnostic ability and radiation exposure of a novel ultra-low-dose CT protocol that allows concomitant coronary artery evaluation and lung screening. METHODS: We studied 30 current or former heavy smoker subjects with suspected or known coronary artery disease who underwent CT assessment of both coronary arteries and thoracic area (Revolution CT, General Electric)...
May 8, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29724775/structural-and-functional-characterization-of-the-contractile-aorta-and-associated-hemocytes-of-the-mosquito-anopheles-gambiae
#3
Leah T Sigle, Julián F Hillyer
The primary pump of the circulatory system of insects is a dorsal vessel that traverses the length of the insect. The anterior portion, located in the head, neck and thorax, is the aorta, and the posterior portion, located in the abdomen, is the heart. Here, we characterize the structure and function of the aorta and conical chamber of the mosquito, Anopheles gambiae The aorta begins in the head with an excurrent opening located above the dorsal pharyngeal plate and ends at the thoraco-abdominal junction where it joins the conical chamber of the heart...
May 3, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29720173/clinical-validation-and-assessment-of-aortic-hemodynamics-using-computational-fluid-dynamics-simulations-from-computed-tomography-angiography
#4
Yulei Zhu, Rui Chen, Yu-Hsiang Juan, He Li, Jingjing Wang, Zhuliang Yu, Hui Liu
BACKGROUND: Hemodynamic information including peak systolic pressure (PSP) and peak systolic velocity (PSV) carry an important role in evaluation and diagnosis of congenital heart disease (CHD). Since MDCTA cannot evaluate hemodynamic information directly, the aim of this study is to provide a noninvasive method based on a computational fluid dynamics (CFD) model, derived from multi-detector computed tomography angiography (MDCTA) raw data, to analyze the aortic hemodynamics in infants with CHD, and validate these results against echocardiography and cardiac catheter measurements...
May 2, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29699582/effects-of-megavoltage-computed-tomographic-scan-methodology-on-setup-verification-and-adaptive-dose-calculation-in-helical-tomotherapy
#5
Jian Zhu, Tong Bai, Jiabing Gu, Ziwen Sun, Yumei Wei, Baosheng Li, Yong Yin
BACKGROUND: To evaluate the effect of pretreatment megavoltage computed tomographic (MVCT) scan methodology on setup verification and adaptive dose calculation in helical TomoTherapy. METHODS: Both anthropomorphic heterogeneous chest and pelvic phantoms were planned with virtual targets by TomoTherapy Physicist Station and were scanned with TomoTherapy megavoltage image-guided radiotherapy (IGRT) system consisted of six groups of options: three different acquisition pitches (APs) of 'fine', 'normal' and 'coarse' were implemented by multiplying 2 different corresponding reconstruction intervals (RIs)...
April 27, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29618353/efficacy-of-virtual-block-objects-in-reducing-the-lung-dose-in-helical-tomotherapy-planning-for-cervical-oesophageal-cancer-a-planning-study
#6
Makoto Ito, Hidetoshi Shimizu, Takahiro Aoyama, Hiroyuki Tachibana, Natsuo Tomita, Chiyoko Makita, Yutaro Koide, Daiki Kato, Tsuneo Ishiguchi, Takeshi Kodaira
BACKGROUND: Intensity-modulated radiotherapy is useful for cervical oesophageal carcinoma (CEC); however, increasing low-dose exposure to the lung may lead to radiation pneumonitis. Nevertheless, an irradiation technique that avoids the lungs has never been examined due to the high difficulty of dose optimization. In this study, we examined the efficacy of helical tomotherapy that can restrict beamlets passing virtual blocks during dose optimization computing (block plan) in reducing the lung dose...
April 4, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29607173/dosimetric-comparison-of-helical-tomotherapy-and-conventional-linac-based-x-knife-stereotactic-body-radiation-therapy-for-primary-lung-cancer-or-pulmonary-metastases
#7
Shuangshuang Li, Ju Yang, Juan Liu, Shanbao Gao, Baorui Liu, Jing Yan
Background: To compare helical tomotherapy (HT) with X-knife stereotactic body radiation therapy (HT-SBRT/X-SBRT) for primary or metastatic lung cancer regarding planning target volume (PTV) coverage, such as homogeneity index (HI), conformity index (CI) and dose-volume histogram (DVH) of organs at risk (OARs). Methods: We retrospectively analyzed 21 patients receiving definitive radiation treatment for non-small cell lung cancer (NSCLC) or pulmonary metastases at our institution between March 2015 and October 2016...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29493372/cardiac-tamponade-as-a-life-threatening-complication-of-laparoscopic-antireflux-surgery-the-real-incidence-and-3d-anatomy-of-a-heart-injury-by-helical-tacks
#8
Mehmet Ali Yerdel, Ozan Şen, Utku Zor, Simay Kara, Bülent Acunaş
BACKGROUND: Cardiac tamponade (CT) is a dreadful complication of laparoscopic antireflux surgery (LARS) with unknown incidence, and preventive measures are yet to be defined. Incidence during LARS with respect to usage/configuration of graft deployment is analyzed. Three-dimensional (3D) analysis of tack distribution provided anatomical insight to prevent cardiac injury. MATERIALS AND METHODS: Data regarding the usage and configuration of graft deployment are retrieved from the prospective database...
March 1, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29474098/comparing-four-radiotherapy-techniques-for-treating-the-chest-wall-plus-levels-iii-iv-draining-nodes-after-breast-reconstruction
#9
Valentina Lancellotta, Martina Iacco, Elisabetta Perrucci, Lorenzo Falcinelli, Claudio Zucchetti, Berardino de Bari, Simonetta Saldi, Cynthia Aristei
OBJECTIVE: To compare the dosimetric outcomes of four radiotherapy (RT) techniques for treating the chest wall plus draining nodes after mastectomy and breast reconstruction. METHODS: Three-dimensional conformal radiotherapy, linac-based intensity modulated RT, helical tomotherapy (HT) and direct tomotherapy treatments were planned for 40 breast cancer patients. Dose prescription was 50 Gy. Plans were compared in terms of doses to the planning target volume, organs at risk and the homogeneity index...
March 19, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29388001/ppar%C3%AE-in-yellow-catfish-pelteobagrus-fulvidraco-molecular-characterization-tissue-expression-and-transcriptional-regulation-by-dietary-cu-and-zn
#10
Wen-Jing You, Xiao-Ying Tan, Guang-Hui Chen, Chuan-Chuan Wei, Dan-Dan Li
Peroxisome proliferator-activated receptor beta (PPARβ) is a ligand-activated transcription factor that plays critical roles in the regulation of many important physiological processes. In this study, PPARβ was cloned and characterized in yellow catfish Pelteobagrus fulvidraco. PPARβ cDNA was 2350 bp in length with an open reading frame (ORF) of 1530 bp, encoding 509 amino acids, a 5'-untranslated region (UTR) of 474 bp, and a 3'-UTR of 346 bp. Similar to mammals, PPARβ protein was predicted to consist of four domains, the A/B domain, DNA-binding domain (DBD), D domain, and ligand-binding domain (LBD)...
April 2018: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29340528/synthesis-and-anti-myocarditis-activity-in-a-multifunctional-lanthanide-microporous-metal-organic-framework-with-1d-helical-chain-building-units
#11
Chenglv Hong, Xinlang Zhou, Weijian Huang, Peiren Shan, Fengquan Dong
A new microporous lanthanide metal-organic framework, {[Yb(BTB)(H2O) (DEF)2}n (1, DEF=N,N-Diethylformamide), with 1D nano-sized channels has been constructed by bridging helical chain secondary building units with 1,3,5-benzenetrisbenzoic acid (H3BTB) ligand. Structural characterization suggests that this complex crystallizes in the hexagonal space group P6122 and possesses 1D triangular channels with coordinated water molecules pointing to the channel center. In addition, anti-myocarditis properties of compound 1 were evaluated in vivo...
January 11, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29298373/an-organic-vortex-laser
#12
Daan Stellinga, Monika E Pietrzyk, James M E Glackin, Yue Wang, Ashu K Bansal, Graham A Turnbull, Kishan Dholakia, Ifor D W Samuel, Thomas F Krauss
Optical vortex beams are at the heart of a number of novel research directions, both as carriers of information and for the investigation of optical activity and chiral molecules. Optical vortex beams are beams of light with a helical wavefront and associated orbital angular momentum. They are typically generated using bulk optics methods or by a passive element such as a forked grating or a metasurface to imprint the required phase distribution onto an incident beam. Since many applications benefit from further miniaturization, a more integrated yet scalable method is highly desirable...
March 27, 2018: ACS Nano
https://www.readbyqxmd.com/read/29179813/a-predictive-model-of-asymmetric-morphogenesis-from-3d-reconstructions-of-mouse-heart-looping-dynamics
#13
Jean-François Le Garrec, Jorge N Domínguez, Audrey Desgrange, Kenzo D Ivanovitch, Etienne Raphaël, J Andrew Bangham, Miguel Torres, Enrico Coen, Timothy J Mohun, Sigolène M Meilhac
How left-right patterning drives asymmetric morphogenesis is unclear. Here, we have quantified shape changes during mouse heart looping, from 3D reconstructions by HREM. In combination with cell labelling and computer simulations, we propose a novel model of heart looping. Buckling, when the cardiac tube grows between fixed poles, is modulated by the progressive breakdown of the dorsal mesocardium. We have identified sequential left-right asymmetries at the poles, which bias the buckling in opposite directions, thus leading to a helical shape...
November 28, 2017: ELife
https://www.readbyqxmd.com/read/29178894/changes-in-overall-ventricular-myocardial-architecture-in-the-setting-of-a-porcine-animal-model-of-right-ventricular-dilation
#14
Peter Agger, Christine Ilkjær, Christoffer Laustsen, Morten Smerup, Jesper R Frandsen, Steffen Ringgaard, Michael Pedersen, John B Partridge, Robert H Anderson, Vibeke Hjortdal
BACKGROUND: Chronic pulmonary regurgitation often leads to myocardial dysfunction and heart failure. It is not fully known why secondary hypertrophy cannot fully protect against the increase in wall stress brought about by the increased end-diastolic volume in ventricular dilation. It has been assumed that mural architecture is not deranged in this situation, but we hypothesised that there might be a change in the pattern of orientation of the aggregations of cardiomyocytes, which would contribute to contractile impairment...
November 27, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29168146/novel-direct-annuloplasty-fastener-system-for-minimally-invasive-mitral-valve-repair
#15
Joshua L Chan, Ming Li, Dumitru Mazilu, Justin G Miller, Andrada C Diaconescu, Keith A Horvath
The development of less invasive approaches for mitral valve repair remains an important objective, particularly in patients with multiple comorbidities. We describe a novel method to affix a mitral valve annuloplasty ring in a minimally invasive manner. A delivery apparatus for an annuloplasty fastener system was designed. Two channels were created, one for advancing the annuloplasty ring, and another to accommodate the fastener applicator. Custom designed fasteners, either with a helical-shaped screw or a strap-shaped tack structure, were tested...
March 2018: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/29105899/left-ventricular-geometry-as-a-major-determinant-of-left-ventricular-ejection-fraction-physiological-considerations-and-clinical-implications
#16
REVIEW
Filippos Triposkiadis, Gregory Giamouzis, Konstantinos Dean Boudoulas, Georgios Karagiannis, John Skoularigis, Harisios Boudoulas, John Parissis
The limited myocardial fibre thickening and shortening alone cannot explain the marked left ventricular (LV) volume reduction during LV ejection. This can only be achieved with LV helical (spiral) orientation of myocardial fibres, which is determined by the non-contractile LV myocardial components (intrasarcomeric and extrasarcomeric cytoskeleton, extracellular matrix). Preservation of LV ejection fraction (LVEF) in heart failure (HF) is due to the presence of normal ellipsoid LV configuration and spiral myocardial fibre orientation...
November 6, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29093491/dosimetric-comparison-of-the-helical-tomotherapy-volumetric-modulated-arc-therapy-and-fixed-field-intensity-modulated-radiotherapy-for-stage-iib-iiib-non-small-cell-lung-cancer
#17
Yujin Xu, Weiye Deng, Shuangyan Yang, Pu Li, Yue Kong, Ye Tian, Zhongxing Liao, Ming Chen
The study aimed to compare the dosimetric parameters to target dose coverage and the critical structures in the treatment planning of helical tomotherapy (TOMO), volumetric-modulated arc therapy (VMAT), and fixed-field intensity-modulated radiotherapy (IMRT) for NSCLC delivering conventionally fractionated radiotherapy. Thirty patients with pathologically confirmed NSCLC were included. Three radiation treatment plans were designed for each patient. All patients received the uniform prescription dose of 60 Gy to the planning target volume...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29059653/blood-motion-turbulent-or-laminar
#18
Alla P Stepanchuk
INTRODUCTION: The issue on the mode of blood motion in the bloodstream, where the arterial and venous flow is significantly different, has been of greater concern recently. However, the conclusions are largely based on the analysis of the geometric orientation in the wall of arteries of smooth muscle elements. The aim of our study was to examine the characteristics of the prominent configuration of cardial cavities and arterial vessels. MATERIALS AND METHODS: The material for study were specimens of human heart, rabbit aorta and arterial microvessels of rat salivary glands, examined by injection and corrosive methods, scanning and transmission electron microscopy...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28986446/the-seca-protein-deeply-penetrates-into-the-secyeg-channel-during-insertion-contacting-most-channel-transmembrane-helices-and-periplasmic-regions
#19
Tithi Banerjee, Zeliang Zheng, Jane Abolafia, Shelby Harper, Donald Oliver
The bacterial Sec-dependent system is the major protein-biogenic pathway for protein secretion across the cytoplasmic membrane or insertion of integral membrane proteins into the phospholipid bilayer. The mechanism of SecA-driven protein transport across the SecYEG channel complex has remained controversial with conflicting claims from biochemical and structural studies regarding the depth and extent of SecA insertion into SecYEG during ongoing protein transport. Here we utilized site-specific in vivo photo-crosslinking to thoroughly map SecY regions that are in contact with SecA during its insertion cycle...
December 1, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28972185/calmodulin-regulates-ca-v-3-t-type-channels-at-their-gating-brake
#20
Jean Chemin, Valentina Taiakina, Arnaud Monteil, Michael Piazza, Wendy Guan, Robert F Stephens, Ashraf Kitmitto, Zhiping P Pang, Annette C Dolphin, Edward Perez-Reyes, Thorsten Dieckmann, Joseph Guy Guillemette, J David Spafford
Calcium (Cav 1 and Cav 2) and sodium channels possess homologous CaM-binding motifs, known as IQ motifs in their C termini, which associate with calmodulin (CaM), a universal calcium sensor. Cav 3 T-type channels, which serve as pacemakers of the mammalian brain and heart, lack a C-terminal IQ motif. We illustrate that T-type channels associate with CaM using co-immunoprecipitation experiments and single particle cryo-electron microscopy. We demonstrate that protostome invertebrate (LCav 3) and human Cav 3...
December 8, 2017: Journal of Biological Chemistry
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