Leo J Engele, Roel L F van der Palen, Anastasia D Egorova, Margot M Bartelings, Lambertus J Wisse, Claire A Glashan, Philippine Kiès, Hubert W Vliegen, Mark G Hazekamp, Barbara J M Mulder, Marco C De Ruiter, Berto J Bouma, Monique R M Jongbloed
In the transposition of the great arteries (TGA), alterations in hemodynamics and oxygen saturation could result in fibrotic remodeling, but histological studies are scarce. We aimed to investigate fibrosis and innervation state in the full spectrum of TGA and correlate findings to clinical literature. Twenty-two human postmortem TGA hearts, including TGA without surgical correction (n = 8), after Mustard/Senning (n = 6), and arterial switch operation (ASO, n = 8), were studied. In newborn uncorrected TGA specimens (1 day-1...
April 20, 2023: Journal of Cardiovascular Development and Disease