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https://www.readbyqxmd.com/read/29334669/anti-obesity-effects-of-clausena-excavata-in-high-fat-diet-induced-obese-mice
#1
Young-Rak Cho, Jung A Lee, Yoon Yeon Kim, Jae-Shin Kang, Jae-Ho Lee, Eun-Kyung Ahn
Clausena excavata (C. excavata) has been used as a traditional medicine for the treatment of abdominal pain, enteritis, dysentery, and malaria. The present study was designed to evaluate the effect of a 50% ethanol extract of C. excavata (ECE) on weight loss, adipocyte size, and obesity-related biochemical parameters in high-fat diet (HFD)-induced obese mice. After 6 weeks of HFD + ECE administration, HFD-induced total fat, subcutaneous fat, and visceral fat were evaluated by micro-computed tomography. The serum levels of triglyceride (TG), total cholesterol (TCH), high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol were evaluated with a biochemical analyzer, and leptin and adiponectin levels in the serum were assessed via enzyme-linked immunoassay (ELISA)...
January 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29334664/methyl-dehydroabietate-counters-high-fat-diet-induced-insulin-resistance-and-hepatic-steatosis-by-modulating-peroxisome-proliferator-activated-receptor-signaling-in-mice
#2
Hiroki Yoshioka, Yuki Mizuno, Tomohiro Yamaguchi, Yoshimi Ichimaru, Koichi Takeya, Yukio Hitotsuyanagi, Tsunemasa Nonogaki, Yutaka Aoyagi
The aim of this study was to investigate the therapeutic effects of methyl dehydroabietate (mDA) on adipocyte differentiation in 3T3-L1 preadipocytes and obesity characteristics induced by high-fat diet (HFD) in mice. Adipocyte differentiation in 3T3-L1 cells was evaluated after 14 days of incubation with mDA. mDA enhanced adipocyte differentiation in 3T3-L1 cells. For the in vivo evaluation, five-week-old male C57BL/6J mice were fed HFD or normal CE-2 diet (control) for eight weeks. During the experimental period, mice were administered mDA (50 mg/kg, p...
January 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29333503/the-effect-of-a-vegan-versus-aha-diet-in-coronary-artery-disease-evade-cad-trial-study-design-and-rationale
#3
Binita Shah, Lisa Ganguzza, James Slater, Jonathan D Newman, Nicole Allen, Edward Fisher, John Larigakis, Francisco Ujueta, Eugenia Gianos, Yu Guo, Kathleen Woolf
Background: Multiple studies demonstrate the benefit of a vegan diet on cardiovascular risk factors when compared to no intervention or usual dietary patterns. The aim of this study is to evaluate the effect of a vegan diet versus the American Heart Association (AHA)-recommended diet on inflammatory and glucometabolic profiles in patients with angiographically defined coronary artery disease (CAD). Study Design: This study is a randomized, open label, blinded end-point trial of 100 patients with CAD as defined by ≥50% diameter stenosis in a coronary artery ≥2 mm in diameter on invasive angiography...
December 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29333380/anti-obesity-property-of-lichen-thamnolia-vermicularis-extract-in-3t3-l1-cells-and-diet-induced-obese-mice
#4
Ra-Yeong Choi, Ju Ri Ham, Jiyoung Yeo, Jae-Seoun Hur, Seok-Kyu Park, Myung-Joo Kim, Mi-Kyung Lee
Thamnolia vermicularis (TV) is an edible lichen that is prevalent in the alpine zone of East Asia. This study evaluated the feasibility of using TV acetone extracts as a functional food based on experiments using cell line and obese mice. The cellular triglyceride levels and Oil red O staining of 3T3-L1 cells indicated that TV extracts (5 and 10 μg/mL) dose-dependently suppressed adipocyte differentiation and lipid accumulation compared with the control. The TV extract (0.4%, w/w) in a high-fat diet (HFD) was supplemented to C57BL/6N mice for 12 weeks, and TV extract supplement significantly reduced visceral fat mass and body weight compared with HFD feeding alone...
December 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29333341/preventive-effects-of-salvia-officinalis-leaf-extract-on-insulin-resistance-and-inflammation-in-a-model-of-high-fat-diet-induced-obesity-in-mice-that-responds-to-rosiglitazone
#5
Mohamed R Ben Khedher, Mohamed Hammami, Jonathan R S Arch, David C Hislop, Dominic Eze, Edward T Wargent, Małgorzata A Kępczyńska, Mohamed S Zaibi
Background: Salvia officinalis (sage) is a native plant to the Mediterranean region and has been used for a long time in traditional medicine for various diseases. We investigated possible anti-diabetic, anti-inflammatory and anti-obesity effects of sage methanol (MetOH) extract in a nutritional mouse model of obesity, inflammation and insulin resistance, as well as its effects on lipolysis and lipogenesis in 3T3-L1 cells. Methods: Diet-induced obese (DIO) mice were treated for five weeks with sage methanol extract (100 and 400 mg kg-1/day bid), or rosiglitazone (3 mg kg-1/day bid), as a positive control...
2018: PeerJ
https://www.readbyqxmd.com/read/29332196/bioelectronic-modulation-of-carotid-sinus-nerve-activity-in-the-rat-a-potential-therapeutic-approach-for-type-2-diabetes
#6
Joana F Sacramento, Daniel J Chew, Bernardete F Melo, Matteo Donegá, Wesley Dopson, Maria P Guarino, Alison Robinson, Jesus Prieto-Lloret, Sonal Patel, Bradley J Holinski, Nishan Ramnarain, Victor Pikov, Kristoffer Famm, Silvia V Conde
AIMS/HYPOTHESIS: A new class of treatments termed bioelectronic medicines are now emerging that aim to target individual nerve fibres or specific brain circuits in pathological conditions to repair lost function and reinstate a healthy balance. Carotid sinus nerve (CSN) denervation has been shown to improve glucose homeostasis in insulin-resistant and glucose-intolerant rats; however, these positive effects from surgery appear to diminish over time and are heavily caveated by the severe adverse effects associated with permanent loss of chemosensory function...
January 14, 2018: Diabetologia
https://www.readbyqxmd.com/read/29331538/differential-lipid-metabolism-outcomes-associated-with-adrb2-gene-polymorphisms-in-response-to-two-dietary-interventions-in-overweight-obese-subjects
#7
O Ramos-Lopez, J I Riezu-Boj, F I Milagro, L Goni, M Cuervo, J A Martinez
BACKGROUND AND AIMS: A precise nutrigenetic management of hypercholesterolemia involves the understanding of the interactions between the individual's genotype and dietary intake. The aim of this study was to analyze the response to two dietary energy-restricted interventions on cholesterol changes in carriers of two ADRB2 polymorphisms. METHODS AND RESULTS: A 4-month nutritional intervention was conducted involving two different hypo-energetic diets based on low-fat (LF) and moderately high-protein (MHP) dietary patterns...
December 5, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29331507/adropin-an-endocrine-link-between-the-biological-clock-and-cholesterol-homeostasis
#8
Sarbani Ghoshal, Joseph R Stevens, Cyrielle Billon, Clemence Girardet, Sadichha Sitaula, Arthur S Leon, D C Rao, James S Skinner, Tuomo Rankinen, Claude Bouchard, Marinelle V Nuñez, Kimber L Stanhope, Deborah A Howatt, Alan Daugherty, Jinsong Zhang, Matthew Schuelke, Edward P Weiss, Alisha R Coffey, Brian J Bennett, Praveen Sethupathy, Thomas P Burris, Peter J Havel, Andrew A Butler
OBJECTIVE: Identify determinants of plasma adropin concentrations, a secreted peptide translated from the Energy Homeostasis Associated (ENHO) gene linked to metabolic control and vascular function. METHODS: Associations between plasma adropin concentrations, demographics (sex, age, BMI) and circulating biomarkers of lipid and glucose metabolism were assessed in plasma obtained after an overnight fast in humans. The regulation of adropin expression was then assessed in silico, in cultured human cells, and in animal models...
December 30, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29331506/hepatocyte-estrogen-receptor-alpha-mediates-estrogen-action-to-promote-reverse-cholesterol-transport-during-western-type-diet-feeding
#9
Lin Zhu, Jeanne Shi, Thao N Luu, Joshua C Neuman, Elijah Trefts, Sophia Yu, Brian T Palmisano, David H Wasserman, MacRae F Linton, John M Stafford
OBJECTIVE: Hepatocyte deletion of estrogen receptor alpha (LKO-ERα) worsens fatty liver, dyslipidemia, and insulin resistance in high-fat diet fed female mice. However, whether or not hepatocyte ERα regulates reverse cholesterol transport (RCT) in mice has not yet been reported. METHODS AND RESULTS: Using LKO-ERα mice and wild-type (WT) littermates fed a Western-type diet, we found that deletion of hepatocyte ERα impaired in vivo RCT measured by the removal of 3H-cholesterol from macrophages to the liver, and subsequently to feces, in female mice but not in male mice...
December 29, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29331496/maternal-betaine-supplementation-attenuates-glucocorticoid-induced-hepatic-lipid-accumulation-through-epigenetic-modification-in-adult-offspring-rats
#10
Nannan Zhao, Shu Yang, Yimin Jia, Bo Sun, Bin He, Ruqian Zhao
There are lots of reports about alleviation of NAFLD by dietary supplements of betaine. However, it remains unclear whether maternal betaine supplementation can also ameliorate NAFLD in offspring. Hence, twenty pregnant rats were fed with a basal diet with or without betaine (1%), and then the female offspring rats were raised at 3 months of age followed by 3 weeks of physiological saline or dexamethasone in a dose of 0.1 mg/kg body mass every day via intraperitoneal injection. In this study, maternal betaine supplementation significantly (P<...
December 11, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29331169/the-introduction-of-simple-cardiorespiratory-fitness-testing-in-overweight-obese-type-2-diabetics-a-pilot-study
#11
Ľubica Cibičková, David Karásek, Jiří Lukeš, Norbert Cibiček
BACKGROUND: Low level of cardiorespiratory fitness has been recognized as an important independent and modifiable risk factor of increased morbidity and mortality. However, in standard outpatient settings, patients are not routinely screened for fitness and advantages of such testing for the management of type 2 diabetes have not been defined. Aim To describe the toleration of a fast, simple and practicable fitness test (2-min step-in-place test) by overweight/obese type 2 diabetics and their performance indicated by 2-min step-in-place test score (STS)...
January 14, 2018: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/29331057/manifestations-and-mechanisms-of-myocardial-lipotoxicity-in-obesity
#12
Arthur C Sletten, Linda R Peterson, Jean E Schaffer
Environmental and socioeconomic changes over the past thirty years have contributed to a dramatic rise in the worldwide prevalence of obesity. Heart disease is among the most serious health risks of obesity, with increases in both atherosclerotic coronary heart disease and heart failure among obese individuals. In this review, we focus on primary myocardial alterations in obesity that include hypertrophic remodeling and diastolic dysfunction. Obesity-associated perturbations in myocardial and systemic lipid metabolism are important contributors to cardiovascular complications of obesity...
January 13, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29330509/transcriptome-analysis-reveals-carbohydrate-mediated-liver-immune-responses-in-epinephelus-akaara
#13
Yunxia Yang, Tao Han, Jia Xiao, Xinyu Li, Jiteng Wang
As the cheapest energy source, carbohydrates are used in fish feeds to improve physical quality and reduce catabolism of proteins and lipids. The liver is the primary organ for metabolism and is also an important site of immune regulation. Here, we investigated the effect of different dietary carbohydrate levels on growth and health by evaluating the liver transcriptome of Epinephelus akaara. In this study, E. akaara juveniles were fed diets containing few (0% corn starch), moderate (18% corn starch), and high (30% corn starch) levels of dietary carbohydrate...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330446/effect-of-puerarin-in-promoting-fatty-acid-oxidation-by-increasing-mitochondrial-oxidative-capacity-and-biogenesis-in-skeletal-muscle-in-diabetic-rats
#14
Xiu-Fang Chen, Lei Wang, Yong-Zheng Wu, Shi-Yu Song, Hai-Yan Min, Yan Yang, Xuan He, Qiao Liang, Long Yi, Yong Wang, Qian Gao
BACKGROUND: Type 2 diabetes is characterized by dyslipidemia and the accumulation of lipids in non-adipose tissue, including skeletal muscle. Puerarin, which is a natural isoflavonoid isolated from the root of the plant Pueraria lobata, has been shown to have antidiabetic activity. However, the lipid-reducing effect of puerarin, in particular in skeletal muscle, has not yet been addressed. METHODS: We examined the effect of puerarin on mitochondrial function and the oxidation of fatty acids in the skeletal muscle of high-fat diet/streptozotocin-induced diabetic rats...
January 12, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29330372/non-estrogenic-xanthohumol-derivatives-mitigate-insulin-resistance-and-cognitive-impairment-in-high-fat-diet-induced-obese-mice
#15
Cristobal L Miranda, Lance A Johnson, Oriane de Montgolfier, Valerie D Elias, Lea S Ullrich, Joshua J Hay, Ines L Paraiso, Jaewoo Choi, Ralph L Reed, Johana S Revel, Chrissa Kioussi, Gerd Bobe, Urszula T Iwaniec, Russell T Turner, Benita S Katzenellenbogen, John A Katzenellenbogen, Paul R Blakemore, Adrian F Gombart, Claudia S Maier, Jacob Raber, Jan F Stevens
Xanthohumol (XN), a prenylated flavonoid from hops, improves dysfunctional glucose and lipid metabolism in animal models of metabolic syndrome (MetS). However, its metabolic transformation into the estrogenic metabolite, 8-prenylnaringenin (8-PN), poses a potential health concern for its use in humans. To address this concern, we evaluated two hydrogenated derivatives, α,β-dihydro-XN (DXN) and tetrahydro-XN (TXN), which showed negligible affinity for estrogen receptors α and β, and which cannot be metabolically converted into 8-PN...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329427/ozone-induced-vascular-contractility-and-pulmonary-injury-are-differentially-impacted-by-diets-enriched-with-coconut-oil-fish-oil-and-olive-oil
#16
Samantha J Snow, Wan-Yun Cheng, Andres Henriquez, Myles Hodge, Virgina Bass, Gail M Nelson, Gleta Carswell, Judy E Richards, Mette C Schladweiler, Allen D Ledbetter, Brian Chorley, Kymberly M Gowdy, Haiyan Tong, Urmila P Kodavanti
Fish, olive, and coconut oil dietary supplementation have several cardioprotective benefits, but it is not established if they protect against air pollution-induced adverse effects. We hypothesized that these dietary supplements would attenuate ozone-induced systemic and pulmonary effects. Male Wistar Kyoto rats were fed either a normal diet, or a diet supplemented with fish, olive, or coconut oil for 8 weeks. Animals were then exposed to air or ozone (0.8 ppm), 4h/day for 2 days. Ozone exposure increased phenylephrine-induced aortic vasocontraction, which was completely abolished in rats fed the fish oil diet...
January 10, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29329013/antiobesity-effect-of-lactobacillus-reuteri-263-associated-with-energy-metabolism-remodeling-of-white-adipose-tissue-in-high-energy-diet-fed-rats
#17
Li-Han Chen, Yi-Hsing Chen, Kuan-Chen Cheng, Ting-Yi Chien, Ching-Hung Chan, Shu-Ping Tsao, Hui-Yu Huang
Obesity is a serious and costly issue to the medical welfare worldwide. Probiotics have been suggested as one of the candidates to resolve the obesity-associated problems, but how they combat obesity is not fully understood. Herein, we investigated the effects of Lactobacillus reuteri 263 (L. reuteri 263) on antiobesity using four groups of Sprague-Dawley rats (n=10/group), namely, C (normal diet with vehicle treatment), HE [high-energy diet (HED) with vehicle treatment], 1X (HED with 2.1×109 CFU/kg/day of L...
November 16, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29327584/gama-aminobutyric-acid-enriched-rice-bran-diet-attenuates-insulin-resistance-and-balances-energy-expenditure-via-modification-of-gut-microbiota-and-scfas
#18
Xu Si, Wenting Shang, Zhongkai Zhou, Guanghou Shui, Sin Man Lam, Christopher L Blanchard, Padraig Strappe
In this study, gama-aminobutyric acid (GABA) enriched rice bran (ERB) was supplemented to obese rats to investigate the attenuation of metabolic syndromes induced by high-fat diet. ERB-containing diet stimulated butyrate and propionate production by promoting Anaerostipes, Anaerostipes sp. and associated synthesizing enzymes. This altered SCFA distribution further enhanced circulatory levels of leptin and glucagon-like peptide-1, controlling food intake by down-regulating orexigenic factors. Together with the enhanced fatty acid β-oxidation highlighted by Prkaa2, Ppara, Scd1 expression via AMPK signaling pathway and Non-alcoholic fatty liver disease pathway, energy expenditure was positively modulated...
January 12, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29327443/effect-of-gut-stress-induced-by-oxidized-wheat-gluten-on-the-growth-performance-gut-morphology-and-oxidative-states-of-broilers
#19
R B Liao, H J Yan, G H Liu, S Zhang, W H Chang, W Liu, C H Lin, X Y Huang, H Y Cai
This study was to investigate the effect of oxidized wheat gluten (OG) on growth performance, gut morphology and its oxidative states of broilers. One hundred and eighty-day-old male broilers (10 chicks/pen) were randomly allocated into three dietary treatments: control diet (CON), diet with 8% wheat gluten (WG) and diet with 8% OG with six pens/treatment. Body weight (BW) (21 and 35 days) and average daily gain (ADG) (1-21 days and 22-35 days) decreased (p < .05) and feed conversion ratio (FCR) (1-21 days and 22-35 days) increased (p < ...
January 11, 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29327229/leopoldia-comosa-prevents-metabolic-disorders-in-rats-with-high-fat-diet-induced-obesity
#20
T Casacchia, F Scavello, C Rocca, M C Granieri, G Beretta, D Amelio, F Gelmini, A Spena, R Mazza, C C Toma, Tommaso Angelone, Giancarlo Statti, T Pasqua
PURPOSE: Obesity is the main feature of a complex illness known as metabolic syndrome. Anti-obesogenic therapies are often associated with side effects and represent a high cost in conventional pharmacological approaches. New strategies based on natural remedies are under continuous investigation. Leopoldia comosa (L.) Parl. (L. comosa) is a spontaneous plant with diuretic, anti-inflammatory and antioxidant properties. Recently, a hypoglycemic activity mediated by inhibition of carbohydrate digestion has been identified...
January 11, 2018: European Journal of Nutrition
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