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https://www.readbyqxmd.com/read/29452135/evidence-based-exercise-recommendations-to-reduce-hepatic-fat-content-in-youth-a-systematic-review-and-meta-analysis
#1
REVIEW
María Medrano, Cristina Cadenas-Sanchez, Celia Álvarez-Bueno, Iván Cavero-Redondo, Jonatan R Ruiz, Francisco B Ortega, Idoia Labayen
The main purposes of this study were to elucidate the effects of supervised-exercise training (ET) interventions on hepatic fat content and on non-alcoholic fatty liver disease (NAFLD) prevalence in children and adolescents and to provide information about the optimal ET prescription (type, intensity, volume, and frequency) needed to reduce hepatic fat content in youths. Supervised-ET interventions performed in children and adolescents (6-19 years) that provided results of exercise effects on hepatic fat content or NAFLD prevalence were included...
February 13, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29451010/assessment-of-mycoplasma-gallisepticum-vaccine-efficacy-in-a-co-infection-challenge-model-with-qx-like-infectious-bronchitis-virus
#2
Dauda G Bwala, Solomon Ponman, Neil Duncan, Daniel B R Wandrag, Celia Abolnik
Mycoplasma gallisepticum (MG) is the primary cause of chronic respiratory disease in poultry. We investigated the protective efficacy of the live attenuated ts-11 and 6/85 MG vaccines against a local MG strain, and in order to enhance symptoms and mimic a typical field situation, we co-infected birds with a virulent strain of QX-like infectious bronchitis virus (IBV). Both vaccines showed similar ability to protect infected chickens from clinical signs, although ts-11 performed slightly better. Despite the lower protection against clinical disease, 6/85-vaccinated birds had significantly (P≤0...
February 16, 2018: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/29435121/lipidomics-reveals-altered-biosynthetic-pathways-of-glycerophospholipids-and-cell-signaling-as-biomarkers-of-the-polycystic-ovary-syndrome
#3
Mariona Jové, Irene Pradas, Alba Naudí, Susana Rovira-Llopis, Celia Bañuls, Milagros Rocha, Manuel Portero-Otin, Antonio Hernández-Mijares, Victor M Victor, Reinald Pamplona
Purpose: In this work, a non-targeted approach was used to unravel changes in the plasma lipidome of PCOS patients. The aim is to offer new insights in PCOS patients strictly selected in order to avoid confounding factors such as dyslipemia, obesity, altered glucose/insulin metabolism, cardiovascular disease, or cancer. Results: Multivariate statistics revealed a specific lipidomic signature for PCOS patients without associated pathologies. This signature implies changes, mainly by down-regulation, in glycerolipid, glycerophospholipid and sphingolipid metabolism suggesting an altered biosynthetic pathway of glycerophospholipids and cell signaling as second messengers in women with PCOS...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29430891/flexible-robotics-in-pelvic-disease-what-pathologies-does-the-catheter-increase-applicability-of-embolic-therapy
#4
Maria A Rueda, Celia Riga, Mohamad S Hamady
Interventional Radiology procedures, equipment and techniques as well as image guidance have developed dramatically over the last few decades. The evidence for minimally invasive interventions in vascular and oncology fields is rapidly growing and several procedures are considered the first line management. However, radiation exposure, image guidance and innovative solutions to known anatomical challenges are still lagging behind. Robotic technology and its role in surgery have been developing at a steady speed...
February 8, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29421602/report-of-two-unrelated-families-with-jalili-syndrome-and-a-novel-nonsense-heterozygous-mutation-in-cnnm4-gene
#5
Célia Márcia Fernandes Maia, Renato Assis Machado, Vera Lúcia Gil-da-Silva-Lopes, Elaine Lustosa-Mendes, Priscila Hae Hyun Rim, Verônica Oliveira Dias, Daniella Reis Barbosa Martelli, Luciano Sólia Nasser, Ricardo D Coletta, Hercílio Martelli-Júnior
Jalili syndrome (JS) is an autosomal recessive disease characterized by a combination of cone-rode retinal dytrophy (CRD) and amelogenesis imperfect (AI). Mutations in cyclin and CBS domain divalent metal cation transport mediator 4 (CNNM4) gene cause JS. Here we described 2 families (3 members) affected by JS. In the first family, JS was caused by the homozygous p.Leu324Pro (c.971T > C) missense mutation and the affected patient developed both CRD and AI. In the second family, a specific combination of a compound heterozygous mutation was found - the p...
February 5, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29414449/mucus-hypersecretion-in-asthma-is-associated-with-rhinosinusitis-polyps-and-exacerbations
#6
Carlos Martínez-Rivera, Astrid Crespo, Celia Pinedo-Sierra, Juan L García-Rivero, Abel Pallarés-Sanmartín, Núria Marina-Malanda, Silvia Pascual-Erquicia, Alicia Padilla, Sagrario Mayoralas-Alises, Vicente Plaza, Antolín López-Viña, César Picado
BACKGROUND: Bronchial hypersecretion is a poorly studied symptom in asthma. The aim of the study was to determine the specific characteristics of asthmatics with bronchial hypersecretion. METHODS: A total of 142 asthmatics (21.8% men; mean age 49.8 years) were prospectively followed for one year. Mucus hypersecretion was clinically classified into two severity categories: daily sputum production and frequent expectoration but not every day. Clinical and pulmonary function variables associated with mucus hypersecretion were assessed by multiple logistic regression analysis...
February 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29395166/usefulness-of-fc-triplex-chagas-leish-igg1-as-confirmatory-assay-for-non-negative-results-in-blood-bank-screening-of-chagas-disease
#7
Fernanda Magalhães Freire Campos, Laura Cotta Repoles, Fernanda Fortes de Araújo, Vanessa Peruhype-Magalhães, Marcelo Antônio Pascoal Xavier, Ester Cerdeira Sabino, Anna Bárbara de Freitas Carneiro Proietti, Mariléia Chaves Andrade, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Célia Maria Ferreira Gontijo
A relevant issue in Chagas disease serological diagnosis regards the requirement of using several confirmatory methods to elucidate the status of non-negative results from blood bank screening. The development of a single reliable method may potentially contribute to distinguish true and false positive results. Our aim was to evaluate the performance of the multiplexed flow-cytometry anti-T. cruzi/Leishmania IgG1 serology/(FC-TRIPLEX Chagas/Leish IgG1) with three conventional confirmatory criteria (ELISA-EIA, Immunofluorescence assay-IIF and EIA/IIF consensus criterion) to define the final status of samples with actual/previous non-negative results during anti-T...
January 30, 2018: Journal of Immunological Methods
https://www.readbyqxmd.com/read/29369790/homeostatic-interplay-between-foxo-protein-and-er-proteostasis-in-cancer-and-other-diseases
#8
REVIEW
Matías González-Quiroz, Hery Urra, Celia María Limia, Claudio Hetz
Cancer cells are exposed to several adverse conditions within the tumor microenvironment that challenge cells to adapt and survive. Several of these homeostatic perturbations insults alter the normal function of the endoplasmic reticulum (ER), resulting in the accumulation of misfolded proteins. ER stress triggers a conserved signaling pathway known as the unfolded protein response (UPR) to cope with the stress or trigger apoptosis of damaged cells. The UPR has been described as a major driver of the acquisition of malignant characteristics that ultimately lead to tumor progression...
January 21, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/29367704/association-of-metreleptin-treatment-and-dietary-intervention-with-neurological-outcomes-in-celia-s-encephalopathy
#9
David Araújo-Vilar, Rosario Domingo-Jiménez, Álvaro Ruibal, Pablo Aguiar, Salvador Ibáñez-Micó, Miguel Garrido-Pumar, Miguel Ángel Martínez-Olmos, Concepción López-Soler, Cristina Guillín-Amarelle, María González-Rodríguez, Antonio Rodríguez-Núñez, Julián Álvarez-Escudero, Mercedes Liñares-Paz, Blanca González-Méndez, Silvia Rodríguez-García, Sofía Sánchez-Iglesias
Celia's encephalopathy (progressive encephalopathy with/without lipodystrophy, PELD) is a recessive neurodegenerative disease that is fatal in childhood. It is caused by a c.985C>T variant in the BSCL2/seipin gene that results in an aberrant seipin protein. We evaluated neurological development before and during treatment with human recombinant leptin (metreleptin) plus a dietary intervention rich in polyunsaturated fatty acids (PUFA) in the only living patient. A 7 years and 10 months old girl affected by PELD was treated at age 3 years with metreleptin, adding at age 6 omega-3 fatty acid supplementation...
January 24, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29349692/ascites-due-to-constrictive-pericardial-disease-not-appreciated-on-echocardiogram-a-report-of-three-cases
#10
Steven-Huy B Han, Celia Yau, Eva E Chin
No abstract text is available yet for this article.
January 18, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29348560/discovery-of-a-small-molecule-protein-kinase-c%C3%AE-selective-activator-with-promising-application-in-colon-cancer-therapy
#11
Cláudia Bessa, Joana Soares, Liliana Raimundo, Joana B Loureiro, Célia Gomes, Flávio Reis, Miguel L Soares, Daniel Santos, Chetna Dureja, Saumya R Chaudhuri, Cynthia Lopez-Haber, Marcelo G Kazanietz, Jorge Gonçalves, Maria F Simões, Patrícia Rijo, Lucília Saraiva
Protein kinase C (PKC) isozymes play major roles in human diseases, including cancer. Yet, the poor understanding of isozymes-specific functions and the limited availability of selective pharmacological modulators of PKC isozymes have limited the clinical translation of PKC-targeting agents. Here, we report the first small-molecule PKCδ-selective activator, the 7α-acetoxy-6β-benzoyloxy-12-O-benzoylroyleanone (Roy-Bz), which binds to the PKCδ-C1-domain. Roy-Bz potently inhibited the proliferation of colon cancer cells by inducing a PKCδ-dependent mitochondrial apoptotic pathway involving caspase-3 activation...
January 18, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29345298/leishmania-amazonensis-isolated-from-human-visceral-leishmaniasis-histopathological-analysis-and-parasitological-burden-in-different-inbred-mice
#12
Celeste da Silva Freitas de Souza, Kátia da Silva Calabrese, Ana Lúcia Abreu-Silva, Luiz Otávio Pereira Carvalho, Flávia de Oliveira Cardoso, Maria Elizabeth Moraes Cavalheiros Dorval, Elisa Teruya Oshiro, Patrícia Flávia Quaresma, Célia Maria Ferreira Gontijo, Raquel da Silva Pacheco, Maria Isabel Doria Rossi, Sylvio Celso Gonçalves da Costa, Tânia Zaverucha do Valle
Leishmania amazonensis is a major etiological agent of human cutaneous leishmaniasis in the Americas; nevertheless there are some reports of this species causing visceral disease in dogs and men. In the present work we have studied a Leishmania strain isolated from a human case of visceral leishmaniasis. We have infected different mouse strains and analyzed the development of the disease, studying the parasite's ability to visceralize and whether this ability is influenced by host genetics. Female BALB/c, C57BL/6, C57BL/10, CBA, DBA/2, and C3H/He mice were subcutaneously infected with 104 L...
January 18, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29320978/two-vessel-branched-stent-graft-for-severely-angulated-aortic-arch-aneurysm-in-a-jehovah-s-witness
#13
Chung S Lim, A Dhutia, Celia Riga, A Dharmadasa, Richard G J Gibbs, Mohamad S Hamady
Aneurysmal disease involving the origins of supra aortic vessels often requires complex open and/or endovascular repair that is not only associated with significant risk of mortality and morbidity but also often with perioperative blood loss requiring transfusion. We report a successful repair of a large thoracic aortic aneurysm (TAA) involving the aortic arch with a custom-made Bolton Relay 2-vessel branched thoracic aortic endograft in a 42-year-old Jehovah's Witness who would otherwise be very unlikely to survive an open repair...
February 2018: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29310977/immune-cells-and-non-immune-cells-with-immune-function-in-mammalian-cochleae
#14
REVIEW
Bo Hua Hu, Celia Zhang, Mitchell D Frye
The cochlea has an immune environment dominated by macrophages under resting conditions. When stressed, circulating monocytes enter the cochlea. These immune mediators, along with cochlear resident cells, organize a complex defense response against pathological challenges. Since the cochlea has minimal exposure to pathogens, most inflammatory conditions in the cochlea are sterile. Although the immune response is initiated for the protection of the cochlea, off-target effects can cause collateral damage to cochlear cells...
December 20, 2017: Hearing Research
https://www.readbyqxmd.com/read/29310361/severe-pertussis-infection-a-clinicopathological-study
#15
Fernando Palvo, Alexandre Todorovic Fabro, Maria Célia Cervi, Davi Casale Aragon, Fernando Silva Ramalho, Ana Paula de Carvalho Panzeri Carlotti
We aimed to investigate the clinicopathological features of pertussis in children admitted to a tertiary-care university hospital in Brazil.This was a retrospective cohort study of all pediatric hospital admissions with pertussis from January 1, 2008 to December 31, 2014. We also reported the autopsy findings in children who died.Fifty-five patients admitted to the hospital over the study period had laboratorial confirmation of Bordetella pertussis infection, 17 (30.9%) needed pediatric intensive care unit (PICU) admission and 6 (10...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29290818/methylation-associated-silencing-of-mir-193a-3p-promotes-ovarian-cancer-aggressiveness-by-targeting-grb7-and-mapk-erk-pathways
#16
Kangmei Chen, Michelle Xin Liu, Celia Sze-Ling Mak, Mingo Ming-Ho Yung, Thomas Ho-Yin Leung, Dakang Xu, Siew-Fei Ngu, Karen Kar-Loen Chan, Huijuan Yang, Hextan Yuen-Sheung Ngan, David Wai Chan
Human growth factor receptor-bound protein-7 (GRB7) is a pivotal mediator involved in receptor tyrosine kinase signaling and governing diverse cellular processes. Aberrant upregulation of GRB7 is frequently associated with the progression of human cancers. However, the molecular mechanisms leading to the upregulation of GRB7 remain largely unknown. Here, we propose that the epigenetic modification of GRB7 at the post-transcriptional level may be a crucial factor leading to GRB7 upregulation in ovarian cancers...
2018: Theranostics
https://www.readbyqxmd.com/read/29284049/leishmania-viannia-braziliensis-infection-in-wild-small-mammals-in-ecotourism-area-of-brazil
#17
Gabriel Barbosa Tonelli, Aline Tanure, Felipe Dutra Rego, Gustavo Mayr de Lima Carvalho, Rodolfo Stumpp, Gabriela Ribeiro Ássimos, Aldenise Martins Campos, Ana Cristina Viana Mariano da Rocha Lima, Célia Maria Ferreira Gontijo, Gustavo Fontes Paz, José Dilermando Andrade Filho
Leishmaniases are parasitic diseases transmitted to mammalian hosts by sand fly vectors (Diptera: Psychodidae). Despite the increasing occurrence of visceral and cutaneous leishmaniasis cases in urban centers, their transmission still occur primarily in wild environments and may be associated with professional activities and recreation, such as ecotourism. The Reserva Particular do Patrimônio Natural Santuário do Caraça (RPPNSC) is one of the largest ecotourism attractions in the State of Minas Gerais, Brazil, and comprises an area of environmental preservation with 11,233 hectares presenting a transitional vegetation between Cerrado and Atlantic Forest...
2017: PloS One
https://www.readbyqxmd.com/read/29248251/dietary-n-3-polyunsaturated-fatty-acid-intake-and-all-cause-and-cardiovascular-mortality-in-adults-on-hemodialysis-the-diet-hd-multinational-cohort-study
#18
Valeria M Saglimbene, Germaine Wong, Marinella Ruospo, Suetonia C Palmer, Katrina Campbell, Vanessa Garcia Larsen, Patrizia Natale, Armando Teixeira-Pinto, Juan-Jesus Carrero, Peter Stenvinkel, Letizia Gargano, Angelo M Murgo, David W Johnson, Marcello Tonelli, Rubén Gelfman, Eduardo Celia, Tevfik Ecder, Amparo G Bernat, Domingo Del Castillo, Delia Timofte, Marietta Török, Anna Bednarek-Skublewska, Jan Duława, Paul Stroumza, Susanne Hoischen, Martin Hansis, Elisabeth Fabricius, Charlotta Wollheim, Jörgen Hegbrant, Jonathan C Craig, Giovanni F M Strippoli
BACKGROUND & AIMS: Patients on hemodialysis suffer from high risk of premature death, which is largely attributed to cardiovascular disease, but interventions targeting traditional cardiovascular risk factors have made little or no difference. Long chain n-3 polyunsaturated fatty acids (n-3 PUFA) are putative candidates to reduce cardiovascular disease. Diets rich in n-3 PUFA are recommended in the general population, although their role in the hemodialysis setting is uncertain. We evaluated the association between the dietary intake of n-3 PUFA and mortality for hemodialysis patients...
December 6, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29243522/experiencing-the-cancer-of-a-loved-one-influences-decision-making-for-breast-cancer-prevention
#19
Tasleem J Padamsee, Anna Muraveva, Lisa D Yee, Celia E Wills, Electra D Paskett
Prior research demonstrates that family history influences breast cancer prevention decisions among healthy women at elevated risk of the disease. Drawing on in-depth interviews with 50 African American and White women, this study reveals an important psychological mechanism of this relationship: exposure to cancer among loved ones. Four distinct categories of cancer exposure (Abstract, Generalized, Practical, and Traumatic), distinguished by the characteristics of women's experiences with cancer among family members and close friends, are associated with differences in knowledge and decisions about breast cancer prevention options...
December 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/29241550/structural-determination-of-the-broadly-reactive-anti-ighv1-69-anti-idiotypic-antibody-g6-and-its-idiotope
#20
Yuval Avnir, Kristina L Prachanronarong, Zhen Zhang, Shurong Hou, Eric C Peterson, Jianhua Sui, Hatem Zayed, Vinodh B Kurella, Andrew T McGuire, Leonidas Stamatatos, Brendan J Hilbert, Markus-Frederik Bohn, Timothy F Kowalik, Jeffrey D Jensen, Robert W Finberg, Jennifer P Wang, Margaret Goodall, Roy Jefferis, Quan Zhu, Nese Kurt Yilmaz, Celia A Schiffer, Wayne A Marasco
The heavy chain IGHV1-69 germline gene exhibits a high level of polymorphism and shows biased use in protective antibody (Ab) responses to infections and vaccines. It is also highly expressed in several B cell malignancies and autoimmune diseases. G6 is an anti-idiotypic monoclonal Ab that selectively binds to IGHV1-69 heavy chain germline gene 51p1 alleles that have been implicated in these Ab responses and disease processes. Here, we determine the co-crystal structure of humanized G6 (hG6.3) in complex with anti-influenza hemagglutinin stem-directed broadly neutralizing Ab D80...
December 12, 2017: Cell Reports
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