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Celia disease

Josseanne Maria Teixeira, Maria do Carmo De Carvalho Martins, Luanne Fortes Monte Soares, Ana Lina De Carvalho Cunha Sales, Daiane Cristina Ferreira Damasceno, Francisco Valmor Macedo Cunha, Regina Célia De Assis, José Carlos Santos Júnior, Nivea Maria Da Costa Sousa
INTRODUCTION: Food and dietetic components have received considerable attention as auxiliary feeding resources on controlling of chronic non-transmissible diseases, among them diabetes. This study evaluated the effect of supplementary diet with multimixture based on linseed, sesame, oats and sunflower seeds on the hepatic function and antioxidant activity of diabetic rats. METHODS: Male rats were distributed on groups of seven animals: diabetic control (DC), diabetics subject to multimixture diet (DM), diabetic with insulin (DI), and normal control (NC)...
September 20, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Francislaine A Dos Reis Lívero, Gracianny Gomes Martins, José Ederaldo Queiroz Telles, Olair Carlos Beltrame, Stellee Marcela Petris Biscaia, Célia Regina Cavichiolo Franco, Ronald P J Oude Elferink, Alexandra Acco
Ethanol abuse is a serious public health problem that is associated with several stages of alcoholic liver disease (ALD) and a high incidence of morbidity and mortality. Alcoholic fatty liver disease (AFLD), the earliest stage of ALD, is a multifactorial injury that involves oxidative stress and disruptions of lipid metabolism. Although benign and reversible, no pharmacological treatments are available for this condition. In the present study, we induced AFLD in mice with 10% ethanol and a low-protein diet and then orally treated them with a hydroethanolic extract of Baccharis trimera (HEBT; 30 mg kg(-1))...
October 15, 2016: Chemico-biological Interactions
Mauricio A Salinas-Santander, Elizabeth Bazan-Mendoza, Marisol Espinoza-Ruiz, Rocio Ortiz-Lopez, Adriana Bustamante, Celia N Sanchez-Dominguez
Cystic fibrosis (CF) is the most common autosomal recessive disease in the Caucasian population, but it has also been widely diagnosed in the Mexican population. Production of viscous secretions affects the secretory epithelia and the respiratory condition usually leads to death. The relationship between the CFTR genotype and the disease phenotype is not well understood. Other risk factors such as genetic and autoimmune influence the development of this disease. We analyzed the PTPN22 R620W polymorphism (+1858 C/T, rs2476601) in 78 DNA samples from CF patients and 232 healthy controls from northeast Mexico using the polymerase chain reaction-restriction fragment length (PCR-RFLP) method...
July 2016: Archives of Medical Research
Patricia Berenice Ramírez Rodríguez, Rodrigo Rosario Cruz, Delia Inés Domínguez García, Rodolfo Hernández Gutiérrez, Rodolfo Esteban Lagunes Quintanilla, Daniel Ortuño Sahagún, Celia González Castillo, Abel Gutiérrez Ortega, Sara Elisa Herrera Rodríguez, Adriana Vallejo Cardona, Moisés Martínez Velázquez
Rhipicephalus (Boophilus) microplus ticks are obligatory hematophagous ectoparasites of cattle and act as vectors for disease-causing microorganisms. Conventional tick control is based on the use of chemical acaricides; however, their uncontrolled use has increased tSresistant tick populations, as well as food and environmental contamination. Alternative immunological tick control has shown to be partially effective. The only anti-tick vaccine commercially available at present in the world is based on intestinal Bm86 protein, and shows a variable effectiveness depending on tick strains or geographic isolates...
October 8, 2016: Experimental Parasitology
Fernanda A Marques, Rodrigo P Soares, Gregório G Almeida, Carolina C Souza, Maria N Melo, Sebastião A Pinto, Valeria B Quixabeira, Ledice I Pereira, Miriam L Dorta, Fatima Ribeiro-Dias, Fernando T Silveira, Sydnei M Silva, Celia M Gontijo, Wagner L Tafuri
American tegumentary leishmaniasis (ATL) is a neglected disease widely distributed in Latin America. In Brazil, it is caused by different Leishmania species belonging to the Subgenera Viannia and Leishmania. ATL diagnosis is routinely based on clinical, epidemiological, parasitological and immunological (delayed-type hypersensitivity skin test-DTH) evidences. The main objective of this work was to determine the efficacy of a previous immunohistochemical (IHC) method developed by our group. Seventy eight skin biopsies from patients with different ATL clinical forms and origins were evaluated...
October 8, 2016: Parasitology International
Lee M Hampton, Laurel Garrison, Jessica Kattan, Ellen Brown, Natalia A Kozak-Muiznieks, Claressa Lucas, Barry Fields, Nicole Fitzpatrick, Luis Sapian, Teresa Martin-Escobar, Stephen Waterman, Lauri A Hicks, Celia Alpuche-Aranda, Hugo Lopez-Gatell
Background.  A Legionnaires' disease (LD) outbreak at a resort on Cozumel Island in Mexico was investigated by a joint Mexico-United States team in 2010. This is the first reported LD outbreak in Mexico, where LD is not a reportable disease. Methods.  Reports of LD among travelers were solicited from US health departments and the European Working Group for Legionella Infections. Records from the resort and Cozumel Island health facilities were searched for possible LD cases. In April 2010, the resort was searched for possible Legionella exposure sources...
September 2016: Open Forum Infectious Diseases
Silvia Cellone Trevelin, Célio Xavier Dos Santos, Raphael Gomes Ferreira, Larissa de Sá Lima, Rangel Leal Silva, Cristoforo Scavone, Rui Curi, José Carlos Alves-Filho, Thiago Mattar Cunha, Pérsio Roxo-Júnior, Maria-Célia Cervi, Francisco Rafael Martins Laurindo, John Stephen Hothersall, Andrew M Cobb, Min Zhang, Aleksandar Ivetic, Ajay M Shah, Lucia Rossetti Lopes, Fernando Queiroz Cunha
The reactive-oxygen-species-(ROS)-generating-enzyme Nox2 is essential for leukocyte anti-microbial activity. However its role in cellular redox homeostasis and, consequently, in modulating intracellular signaling pathways remains unclear. Herein, we show Nox2 activation favors thioredoxin-1 (TRX-1)/p40phox interaction, which leads to exclusion of TRX-1 from the nucleus. In contrast, the genetic deficiency of Nox2 or its pharmacological inhibition with apocynin (APO) results in reductive stress after lipopolysaccharide-(LPS)-cell stimulation, which causes nuclear accumulation of TRX-1 and enhanced transcription of inflammatory mediators through nuclear-factor-(NF)-κB...
October 4, 2016: Scientific Reports
Kambis Sadeghi, Lukas Wisgrill, Isabelle Wessely, Susanne C Diesner, Simone Schüller, Celia Dürr, Armando Heinle, Monika Sachet, Arnold Pollak, Elisabeth Förster-Waldl, Andreas Spittler
Toll-like receptors (TLR) are crucial sensors of microbial agents such as bacterial or viral compounds. These receptors constitute key players in the induction of inflammation, e.g. in septic or chronic inflammatory diseases. Colony-stimulating factors (CSFs) such as granulocyte-macrophage-CSF (GM-CSF) or granulocyte-CSF (G-CSF) have been extensively investigated in their capacity to promote myelopoiesis in febrile neutropenia or to overcome immunosuppression in patients suffering from sepsis-associated neutropenia or from monocytic immunoincompetence...
2016: PloS One
Nathaniel Lizak, Alessandra Lugaresi, Raed Alroughani, Jeannette Lechner-Scott, Mark Slee, Eva Havrdova, Dana Horakova, Maria Trojano, Guillermo Izquierdo, Pierre Duquette, Marc Girard, Alexandre Prat, Pierre Grammond, Raymond Hupperts, Francois Grand'Maison, Patrizia Sola, Eugenio Pucci, Roberto Bergamaschi, Celia Oreja-Guevara, Vincent Van Pesch, Cristina Ramo, Daniele Spitaleri, Gerardo Iuliano, Cavit Boz, Franco Granella, Javier Olascoaga, Freek Verheul, Csilla Rozsa, Edgardo Cristiano, Shlomo Flechter, Suzanne Hodgkinson, Maria Pia Amato, Norma Deri, Vilija Jokubaitis, Tim Spelman, Helmut Butzkueven, Tomas Kalincik
OBJECTIVE: To evaluate variability and predictability of disability trajectories in moderately advanced and advanced multiple sclerosis (MS), and their modifiability with immunomodulatory therapy. METHODS: The epochs between Expanded Disability Status Scale (EDSS) steps 3-6, 4-6 and 6-6.5 were analysed. Patients with relapse-onset MS and having reached 6-month confirmed baseline EDSS step (3/4/6) were identified in MSBase, a global observational MS cohort study...
September 28, 2016: Journal of Neurology, Neurosurgery, and Psychiatry
Célia Minvielle
OBJECTIVE: Cardiovascular disease is the first cause of death in developed countries. Cardiac rehabilitation (CR) plays an important role in secondary prevention, especially after an acute coronary syndrome (ACS). Despite the high recommendation for its prescription, less than a third of eligible patients participate in France. We sought to assess the role of the CR in the management of ACS in Cardiology Haut-Leveque hospital and identify obstacles to its prescription. MATERIAL/PATIENTS AND METHODS: In this prospective and observational study, a questionnaire about CR was completed by cardiologists for each patient admitted for an ACS in our institution, from June to October 2014...
September 2016: Annals of Physical and Rehabilitation Medicine
Celia Kun-Rodrigues, Owen A Ross, Tatiana Orme, Claire Shepherd, Laura Parkkinen, Lee Darwent, Dena Hernandez, Olaf Ansorge, Lorraine N Clark, Lawrence S Honig, Karen Marder, Afina Lemstra, Philippe Scheltens, Wiesje van der Flier, Eva Louwersheimer, Henne Holstege, Ekaterina Rogaeva, Peter St George-Hyslop, Elisabet Londos, Henrik Zetterberg, Imelda Barber, Anne Braae, Kristelle Brown, Kevin Morgan, Walter Maetzler, Daniela Berg, Claire Troakes, Safa Al-Sarraj, Tammaryn Lashley, Janice Holton, Yaroslau Compta, Vivianna Van Deerlin, John Q Trojanowski, Geidy E Serrano, Thomas G Beach, Jordi Clarimon, Alberto Lleó, Estrella Morenas-Rodríguez, Suzanne Lesage, Douglas Galasko, Eliezer Masliah, Isabel Santana, Monica Diez, Pau Pastor, Pentti J Tienari, Liisa Myllykangas, Minna Oinas, Tamas Revesz, Andrew Lees, Brad F Boeve, Ronald C Petersen, Tanis J Ferman, Valentina Escott-Price, Neill Graff-Radford, Nigel J Cairns, John C Morris, David J Stone, Stuart Pickering-Brown, David Mann, Dennis W Dickson, Glenda M Halliday, Andrew Singleton, Rita Guerreiro, Jose Bras
C9orf72 repeat expansions are a common cause of amyotrophic lateral sclerosis and frontotemporal dementia. To date, no large-scale study of dementia with Lewy bodies (DLB) has been undertaken to assess the role of C9orf72 repeat expansions in the disease. Here, we investigated the prevalence of C9orf72 repeat expansions in a large cohort of DLB cases and identified no pathogenic repeat expansions in neuropathologically or clinically defined cases, showing that C9orf72 repeat expansions are not causally associated with DLB...
September 2, 2016: Neurobiology of Aging
Miriam A Balderas, Chinh Nguyen, Austen Terwilliger, Wendy A Keitel, Angelina Iniguez, Rodrigo Torres, Frederico Palacios, Celia W Goulding, Anthony W Maresso
Bacillus anthracis is a sporulating Gram-positive bacterium that is the causative agent of anthrax and a potential weapon of bioterrorism. The U.S. licensed anthrax vaccine is made from an incompletely characterized culture supernatant of a nonencapsulated, toxigenic strain (anthrax vaccine absorbed - AVA) whose primary protective component is thought to be protective antigen (PA). AVA is effective in protecting animals and elicits toxin-neutralizing antibodies in humans, but enthusiasm is dampened by its undefined composition, multi-shot regimen, recommended boosters, and potential for adverse reactions...
September 19, 2016: Infection and Immunity
Lucas Nojosa Oliveira, Luciana Casaletti, Sônia Nair Báo, Clayton Luiz Borges, Patrícia de Sousa Lima, Célia Maria de Almeida Soares
Paracoccidioidomycosis is an endemic disease in Latin America, caused by thermo dimorphic fungi of the genus Paracoccidioides. Although previous proteome analyses of Paracoccidioides spp. have been carried out, the nuclear subproteome of this pathogen has not been described. In this way, we aimed to characterize the nuclear proteome of Paracoccidioides species, in the yeast form. For that, yeast cells were disrupted and submitted to cell fractionation. The purity of the nuclear fraction was confirmed by fluorescence and electron microscopy...
October 2016: Fungal Biology
José Sergio Zepeda-Nuño, Celia Guerrero-Velázquez, Susana Del Toro-Arreola, Natali Vega-Magaña, Julián Ángeles-Sánchez, Jesse Haramati, Ana L Pereira-Suárez, Miriam R Bueno-Topete
ADAM10 has been implicated in the progression of various solid tumors. ADAM10 regulates the cleavage of the FasL ectodomain from the plasma membrane of different cell types, generating the soluble FasL fragment (sFasL). Currently, there are few studies in oral squamous cell carcinoma (OSCC) that correlate levels of ADAM10 and FasL in the tumor microenvironment with clinical parameters of the disease. To determine the expression of ADAM10, Fas, FasL and sFasL in patients with OSCC and its association with TNM stage...
September 14, 2016: Pathology Oncology Research: POR
Sergio Santos-Alarcon, Celia Sanchis-Sanchez, Almudena Mateu-Puchades
BACKGROUND: Darier's disease (DD) is an autosomal dominant skin disorder which causative gene, ATP2A2, is located atchromosome 12q23-24. The lesions of DD are skin-coloured to brown, hyperkeratotic, greasy papules that coalesce into warty plaques commonly involving the seborrhoeic areas of the trunk and face, especially the scalp margins, temples, ears, and scalp. The most common complaint associated with the disease is itching, with exacerbations attributed to heat, sweating, sunlight, lithium, steroid therapy, stress, and menstruation OBJECTIVES: We report a patient with DD treated with topical diclofenac sodium 3%...
2016: Dermatology Online Journal
Andreia Pereira, Roberto Palma Dos Reis, Ricardo Rodrigues, Ana Célia Sousa, Susana Gomes, Sofia Borges, Ilidio Ornelas, Ana Isabel Freitas, Graça Guerra, Eva Henriques, Mariana Rodrigues, Sónia Freitas, Carolina Freitas, António Brehm, Décio Pereira, Maria Isabel Mendonça
Recent genetic studies have revealed an association between polymorphisms at the ADAMTS7 gene locus and coronary artery disease (CAD) risk. Functional studies have shown that a CAD-associated polymorphism (rs3825807) affects ADAMTS7 maturation and VSMC migration. Here, we tested whether ADAMTS7 (A/G) SNP is associated with cardiovascular (CV) survival in patients with established CAD. A cohort of 1128 patients with angiographic proven CAD, who were followed-up prospectively for a mean follow-up of 63 (range 6 -182) months, were genotyped for rs3825807 A/G...
September 9, 2016: Physiological Genomics
Emma Dures, Isobel Fraser, Celia Almeida, Alice Peterson, Judy Caesley, Jon Pollock, Nicholas Ambler, Marianne Morris, Sarah Hewlett
OBJECTIVES: Psychological support for inflammatory arthritis is recommended in rheumatology treatment guidelines. Previous research found that high numbers of patients would access such support but that provision is often inconsistent and inadequate. The present study explored patients' perspectives on the nature of the psychological impact of inflammatory arthritis and how to meet the associated support needs. METHODS: A cross-sectional survey was conducted, using questionnaires which included three open-ended questions about helpful and unhelpful psychological support...
September 8, 2016: Musculoskeletal Care
Samira Benhammou, Leticia Heras-González, Diana Ibáñez-Peinado, Carla Barceló, May Hamdan, Ana M Rivas, Miguel Mariscal-Arcas, Fatima Olea-Serrano, Celia Monteagudo
Fruit, vegetables, cereals, and olive oil are common elements of the Mediterranean diet (MD), but each country in the Mediterranean basin has its own gastronomic customs influenced by socio-cultural, religious, and economic factors. This study compared the dietary habits of three Mediterranean populations with different cultures and lifestyles, a total of 600 adults (61.9% females) between 25 and 70 yrs from Spain, Morocco, and Palestine. All participants completed a self administered questionnaire, including sociodemographic and anthropometric items, a validated semi-quantitative food frequency questionnaire adapted to the foods consumed in each country, and three 24-h recalls...
September 2, 2016: Appetite
Scott H Watterson, George V De Lucca, Qing Shi, Charles M Langevine, Qingjie Liu, Douglas G Batt, Myra Beaudoin Bertrand, Hua Gong, Jun Dai, Shiuhang Yip, Peng Li, Dawn Sun, Dauh-Rurng Wu, Chunlei Wang, Yingru Zhang, Sarah C Traeger, Mark A Pattoli, Stacey Skala, Lihong Cheng, Mary T Obermeier, Rodney Vickery, Lorell N Discenza, Celia J D'Arienzo, Yifan Zhang, Elizabeth Heimrich, Kathleen M Gillooly, Tracy L Taylor, Claudine Pulicicchio, Kim W McIntyre, Michael A Galella, Andy J Tebben, Jodi K Muckelbauer, ChiehYing Chang, Richard Rampulla, Arvind Mathur, Luisa Salter-Cid, Joel C Barrish, Percy H Carter, Aberra Fura, James R Burke, Joseph A Tino
Bruton's tyrosine kinase (BTK), a nonreceptor tyrosine kinase, is a member of the Tec family of kinases. BTK plays an essential role in B cell receptor (BCR)-mediated signaling as well as Fcγ receptor signaling in monocytes and Fcε receptor signaling in mast cells and basophils, all of which have been implicated in the pathophysiology of autoimmune disease. As a result, inhibition of BTK is anticipated to provide an effective strategy for the clinical treatment of autoimmune diseases such as lupus and rheumatoid arthritis...
October 13, 2016: Journal of Medicinal Chemistry
Romain Arnal, Gülen Ayhan, Éric Pinganaud, Célia Basurko, Louis Jehel
Despite the recent interest in psychiatric illness in prison, the psychopathology of the Remire-Montjoly prison population remains largely unknown. Subject to significant population movements, French Guiana and its prison houses a very mixed population in which recent history has left a strong mark (earthquake in Haïti, civil war in Suriname, violence related to gold mining population and drug trafficking). These negative life events appear as potential vectors of psychological trauma. Additionally, strong links have been established in the literature between post-traumatic stress disorder (PTSD) and many other psychiatric disorders, including suicidal behavior and addictions...
2016: Santé Mentale Au Québec
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