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Bullous pemphigoid

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https://www.readbyqxmd.com/read/29136295/genome-wide-association-study-identifies-galc-as-susceptibility-gene-for-mucous-membrane-pemphigoid
#1
C D Sadik, J Bischof, N van Beek, A Dieterich, S Benoit, M Sárdy, M Worm, S Meller, R Gläser, D Zillikens, B Homey, J Setterfield, D Minassian, E Schmidt, J Dart, S M Ibrahim
BACKGROUND: Mucous membrane pemphigoid (MMP) is a rare, chronic, and often aggressive subepidermal autoimmune blistering disease potentially affecting several mucous membranes with blisters and secondary erosions and scars. The pathogenesis of MMP is poorly understood, and the contribution of genetic predispositions, other than HLA class II allele variants to MMP, is unknown. OBJECTIVES: The objective of this study is to identify susceptibility genes for MMP in a British cohort of MMP patients...
November 14, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/29136264/biological-and-clinical-response-to-omalizumab-in-a-patient-with-bullous-pemphigoid
#2
Sébastien Menzinger, Gürkan Kaya, Enno Schmidt, Lionel Fontao, Emmanuel Laffitte
No abstract text is available yet for this article.
November 14, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29135016/light-chain-deposition-disease-with-bullous-skin-lesions-mimicking-atypical-bullous-pemphigoid
#3
Marion Malphettes, Pauline Bonnet, Pierre Schneider, Marguerite Vignon, Marine Baron, Jean-David Bouaziz, Maxime Battistella
No abstract text is available yet for this article.
August 23, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29131038/bullous-diseases
#4
Caroline Corbaux, Pascal Joly
Autoimmune bullous diseases are a heterogeneous group of blistering diseases affecting the skin and/or mucous membrane. Systemic corticosteroids, which are often associated with immunosuppressants, are the main treatment option for these diseases. The 2 main biologics used in the treatment of autoimmune bullous diseases are rituximab, especially in pemphigus and mucous membrane pemphigoid, and omalizumab in bullous pemphigoid. Rituximab is a promising therapeutic option in pemphigus and mucous membrane pemphigoid...
2018: Current Problems in Dermatology
https://www.readbyqxmd.com/read/29111983/acute-flare-of-bullous-pemphigus-with-pembrolizumab-used-for-treatment-of-metastatic-urothelial-cancer
#5
Rohan Garje, Justin J Chau, Jina Chung, Karolyn Wanat, Yousef Zakharia
In the past decade, the resurgence of immunotherapy has changed the landscape of cancer therapy. Checkpoint inhibitors targeting cytotoxic T-lymphocyte antigen-4, programmed death-1 on lymphocytes, and programmed death ligand-1 on tumors cells are currently utilized in the management of several cancers. These agents are double-edged sword with the positive effect being robust antitumor response but on the other side they can throttle up the normal immunologic homeostasis in a negative way, leading to adverse autoimmune toxicities...
November 3, 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29105148/biomarkers-related-to-bullous-pemphigoid-activity-and-outcome
#6
REVIEW
Delphine Giusti, Sébastien Le Jan, Gregory Gatouillat, Philippe Bernard, Bach Nga Pham, Frank Antonicelli
Bullous pemphigoid (BP) is the most common autoimmune sub-epidermal blistering disease of the skin. Investigation of the BP-associated pathophysiological processes during the last decades showed that the generation of auto-antibodies directed against the hemidesmosome proteins BP180 and BP230, a hallmark of the BP-associated autoimmune response, leads to the recruitment of inflammatory immune cells at the dermal-epidermal junction, and subsequently to the release of a large amount of inflammatory molecules involved in blister formation...
November 3, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/29102490/nonbullous-cutaneous-pemphigoid-a-systematic-review
#7
REVIEW
Aniek Lamberts, Joost M Meijer, Marcel F Jonkman
BACKGROUND: Cutaneous pemphigoid (bullous pemphigoid) is an autoimmune bullous disease that typically presents with tense bullae and severe pruritus. However, bullae may be lacking, a subtype termed nonbullous cutaneous pemphigoid. OBJECTIVE: To summarize the reported characteristics of nonbullous cutaneous pemphigoid. METHODS: The EMBASE and MEDLINE databases were searched using 'nonbullous cutaneous pemphigoid' and various synonyms. Case reports and series describing nonbullous cutaneous pemphigoid were included...
November 1, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29090462/ethnic-variations-in-the-epidemiology-of-bullous-pemphigoid-in-israel
#8
Khalaf Kridin, Reuven Bergman
BACKGROUND: No ethnic or geographic predisposition to bullous pemphigoid (BP) was reported so far. OBJECTIVE: To evaluate trends in the incidence of BP in northern Israel, shedding light on differences between two distinct ethnic populations who inhabit the same region, namely Jews and Arabs. METHODS: Bullous pemphigoid incidence was retrospectively estimated from January 2000-December 2015 in two Israeli regions with a total population of 1...
October 31, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29071428/ige-autoantibodies-and-their-association-with-the-disease-activity-and-phenotype-in-bullous-pemphigoid-a-systematic-review
#9
REVIEW
Ariadne Hadjikyriacou Saniklidou, Patrick J Tighe, Lucy C Fairclough, Ian Todd
Bullous pemphigoid (BP) is the most common autoimmune skin disease of blistering character. The underlying pathophysiological mechanism involves an immune attack, usually by IgG class autoantibodies, on the autoantigen BP 180/BPAg2, which is a type XVII collagen (COL17) protein acting as the adhesion molecule between the epidermis and the basement membrane of the dermis. About 40 years ago, following consistent findings of elevated total serum IgE levels in BP patients, it was hypothesized that IgE may be involved in the pathophysiology of BP...
October 25, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29055144/increased-prevalence-of-diabetes-mellitus-in-bullous-pemphigoid-patients-during-the-last-decade
#10
Luca Fania, Giovanni Di Zenzo, Biagio Didona, Maria Antonietta Pilla, Luciano Sobrino, Annarita Panebianco, Cinzia Mazzanti, Damiano Abeni
Bullous pemphigoid (BP) is a rare autoimmune blistering disease. The association between BP and diabetes mellitus (DM) has been previously reported with inconsistent results(1-4) . Dipeptidyl peptidase (DPP)-IV inhibitors, approved in Europe by EMA in 2007 to treat type-2 DM, are antihyperglycemic drugs that could induce BP disease(5-9) . This article is protected by copyright. All rights reserved.
October 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29054606/semaphorin-4d-from-cd15-granulocytes-via-adam10-induced-cleavage-contributes-to-antibody-production-in-bullous-pemphigoid
#11
Shengxian Shen, Yao Ke, Erle Dang, Hui Fang, Yuqian Chang, Jieyu Zhang, Zhenlai Zhu, Shuai Shao, Pei Qiao, Tongmei Zhang, Hongjiang Qiao, Gang Wang
Autoreactive B cells activation and antibody production are critical events for the development of bullous pemphigoid (BP). However, the mechanism that is involved in the modulation of B cell activation and autoantibody generation has not been fully understood. Semaphorin 4D (Sema4D/CD100) plays important roles in immune regulation related to B cell, but its implication in BP remains obscure. The aim of our study was to characterize Sema4D and the underlying mechanism contributing to the autoimmune features of BP...
October 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29040970/use-of-dipeptidyl-peptidase-iv-inhibitors-and-bullous-pemphigoid
#12
Clara Schaffer, Thierry Buclin, Francois R Jornayvaz, Simone Cazzaniga, Luca Borradori, Michel Gilliet, Laurence Feldmeyer
No abstract text is available yet for this article.
October 18, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29033436/bullous-pemphigoid-presenting-with-esophagitis-dissecans-superficialis
#13
Kunimitsu Inoue, Tomoya Okajima, Osamu Okamoto, Kazunari Murakami
No abstract text is available yet for this article.
October 16, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29028121/lupus-like-cutaneous-reaction-following-pembrolizumab-an-immune-related-adverse-event-associated-with-anti-pd-1-therapy
#14
Kimberly Shao, Suzanne McGettigan, Rosalie Elenitsas, Emily Y Chu
PD-1 (programmed cell death-1) inhibitors, used to treat metastatic melanoma and other malignancies, are associated with development of immune-related adverse events in the skin. Such reactions include morbilliform eruptions, vitiligo, alopecia areata, and bullous pemphigoid. In this report, we describe a patient who developed a lupus-like cutaneous reaction in the setting of pembrolizumab therapy for metastatic melanoma, adding to the spectrum of reactions which may be observed in association with PD-1 inhibitor therapy...
October 13, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29025244/a-comparative-study-of-expression-of-fc-receptors-in-relation-to-the-autoantibody-mediated-immune-response-and-neutrophil-elastase-expression-in-autoimmune-blistering-dermatoses
#15
Justyna Gornowicz-Porowska, Agnieszka Seraszek-Jaros, Monika Bowszyc-Dmochowska, Elżbieta Kaczmarek, Paweł Pietkiewicz, Paweł Bartkiewicz, Marian Dmochowski
Here we investigated the cutaneous CD32A and CD89 expression in relation to the neutrophil elastase (NE) expression and serum level of anti-desmoglein 1 and 3 (DSG1/DSG3) IgG in pemphigus, anti-BP180/BP230 IgG in bullous pemphigoid (BP), anti-gliadin nonapeptides (npG), tissue (tTG), and epidermal transglutaminases (eTG) IgA in dermatitis herpetiformis (DH). The examined material consisted of skin/mucosal tissues and sera. In total, 87 patients were studied. Immunohistochemistry on paraffin-embedded sections with quantitative digital morphometry was used to measure the intensity of CD32A/CD89/NE expressions...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29024082/paraneoplastic-bullous-pemphigoid-associated-with-penile-squamous-cell-carcinoma
#16
Anuradha Bishnoi, Tarun Narang, Sanjeev Handa, Vikarn Vishwajeet, Uma Nahar Saikia, Rakesh Kapoor, Ravimohan S Mavuduru
A 43-year-old farmer presented to us for evaluation of multiple, itchy, tense vesicles and bullae, containing clear to hemorrhagic fluid, surmounting an urticarial background on his thighs and inguinal area for 20-days (Figure 1a). He was also undergoing evaluation for bilateral metastatic inguinal lymphadenopathy detected 3 months back that had revealed squamous cell carcinoma on cytology. Search for primary was still on. Genital examination incidentally revealed a bright red, well-defined, verrucous plaque on glans penis (Figure 1b)...
October 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28987492/detection-and-characterization-of-igg-ige-and-iga-autoantibodies-in-patients-with-bullous-pemphigoid-associated-with-dipeptidyl-peptidase-iv-inhibitors
#17
Luca Fania, Adele Salemme, Alessia Provini, Gianluca Pagnanelli, Maria Chiara Collina, Damiano Abeni, Biagio Didona, Giovanni Di Zenzo, Cinzia Mazzanti
No abstract text is available yet for this article.
October 4, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28966536/vesicular-bullous-pemphigoid-in-a-23-year-old-male
#18
Won Jin Hong, Soo-Chan Kim
No abstract text is available yet for this article.
October 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28963378/man-with-leg-rash
#19
Michael Huynh Hwang, Ziyad Khesbak, Yiju Teresa Liu
CLINICAL INTRODUCTION: A 51-year-old male presented to the ED with a rash to his left thigh (figure 1) with erythema, swelling and pain. He endorsed paraesthesias, pruritus, fevers, vomiting and diarrhoea. Initial vitals were unremarkable. He was well appearing with an 8×8 cm violaceous patch on his left medial thigh with vesicles, surrounding erythema and induration with a second, smaller lesion on the right thigh. Both rashes were extremely tender.emermed;34/10/686/F1F1F1Figure 1Erythematosus and vesicular rash in bilateral legs...
October 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28940316/doxycycline-compared-to-prednisolone-therapy-for-patients-with-bullous-pemphigoid-cost-effectiveness-analysis-of-the-blister-trial
#20
J M Mason, J R Chalmers, T Godec, A J Nunn, G Kirtschig, F Wojnarowska, M Childs, D Whitham, E Schmidt, K Harman, S Walton, A Chapman, H C Williams
BACKGROUND: Bullous pemphigoid (BP) is an autoimmune blistering skin disorder associated with significant morbidity and mortality. Doxycycline and prednisolone to treat bullous pemphigoid were compared within a randomised controlled trial (RCT). OBJECTIVES: To compare the cost-effectiveness of doxycycline-initiated and prednisolone-initiated treatment for patients with BP. METHODS: a multicentre, parallel-group, investigator-blinded RCT. Within-trial analysis used bivariate regression of costs and QALYs, with multiple imputation of missing data, informing a probabilistic assessment of incremental treatment cost-effectiveness from a health service perspective RESULTS: In the base case, there was no robust difference in costs or QALYs per patient at 1 year comparing doxycycline-initiated therapy with prednisolone-initiated therapy (net cost: £959, 95% CI -£24 to £1941; net QALYs: -0...
September 22, 2017: British Journal of Dermatology
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