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Bullous pemphigoid

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https://www.readbyqxmd.com/read/28338219/human-orf-complicated-by-epidermolysis-bullosa-acquisita
#1
E Zuelgaray, C Salle de Chou, J Gottlieb, M Battistella, M D Vignon-Pennamen, M Bagot, F Guibal, J D Bouaziz
Orf is a DNA parapoxvirus transmitted to humans by contact with infected goats and sheep. Many complications have been reported after Orf infection including erythema multiforme. A few cases of auto-immune bullous dermatosis complicating Orf disease have been reported to date, usually characterized by tense blisters eruptions with or without mucosal involvement, linear deposition of C3, IgG and/or IgA along the basement membrane and negativity of indirect immunofluorescence analysis and ELISA assays (performed in 4 of 11 reported cases) against target antigens of bullous pemphigoid, mucous membrane pemphigoid or epidermolysis bullosa acquisita, except one case of mucosal pemphigoid with antilaminin-332 antibodies...
March 24, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28337472/bullous-pemphigoid-localized-in-a-primarily-hemiplegic-distribution
#2
Sean Dreyer, Maria Aleshin, Lorraine Young
No abstract text is available yet for this article.
March 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28331352/skin-disorders-in-parkinson-s-disease-potential-biomarkers-and-risk-factors
#3
REVIEW
Astrid-Helene Ravn, Jacob P Thyssen, Alexander Egeberg
Parkinson's disease (PD) is one of the most common neurodegenerative disorders, characterized by a symptom triad comprising resting tremor, rigidity, and akinesia. In addition, non-motor symptoms of PD are well recognized and often precede the overt motor manifestations. Cutaneous manifestations as markers of PD have long been discussed, and cumulative evidence shows an increased prevalence of certain dermatological disorders in PD. Seborrheic dermatitis is considered to occur as a premotor feature of PD referable to dysregulation of the autonomic nervous system...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28329498/bullous-pemphigoid-of-infancy-report-and-review-of-infantile-and-pediatric-bullous-pemphigoid
#4
Bárbara R Ferreira, Ana S Vaz, Leonor Ramos, José P Reis, Margarida Gonçalo
A 4-month-old infant was observed with an acute itchy bullous dermatosis, predominantly involving the extremities, which revealed a dermal infiltrate rich in eosinophils, C3 deposits at the dermalepidermal junction, and circulating antibodies to BP180 antigen, confirming the diagnosis of bullous pemphigoid. He was initially treated with deflazacort 1 mg/kg/day, further increased to 2 mg/ kg/day, followed by reduction over seven weeks with complete clinical resolution within this period. We discuss epidemiology, etiology, relationship with vaccination, clinical features, and treatment of thisrelatively rare bullous dermatosis in the pediatric age...
February 16, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28323786/reply-to-direct-immunofluorescence-findings-in-discoid-lupus-erythematosus-and-bullous-pemphigoid
#5
Chika Ohata, Bungo Ohyama, Hiroshi Nagata, Minao Furumura, Takekuni Nakama
No abstract text is available yet for this article.
April 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28317060/prognostic-factors-for-mortality-in-patients-with-bullous-pemphigoid-a-meta-analysis
#6
Yi-Di Liu, Yan-Hong Wang, Yi-Cong Ye, Wen-Ling Zhao, Li Li
Bullous pemphigoid (BP) is a chronic debilitating autoimmune blistering disease that frequently occurs in the elderly population. Previous studies have suggested a high morbidity and mortality associated with BP. However, relatively few studies have investigated prognostic factors of BP mortality, and they showed considerably various results. This meta-analysis aimed to quantitatively assess the association between several potential prognostic factors and risk of mortality in bullous pemphigoid. A comprehensive search was performed using Pubmed, Embase, and Cochrane Library...
March 19, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28286109/bullous-pemphigoid
#7
REVIEW
Işın Sinem Bağcı, Orsolya N Horváth, Thomas Ruzicka, Miklós Sárdy
Bullous pemphigoid (BP) is the most common autoimmune bullous disorder which is characterized by autoantibodies against hemidesmosomal proteins of the skin and mucous membranes. Collagen XVII and dystonin-e have been identified as target antigens. BP affects mostly the elderly. The incidence of the disease is increasing gradually and is associated with high morbidity and mortality. Clinically, BP is characterized by an intensely pruritic eruption with widespread bullous lesions. The clinical diagnosis can be challenging in the setting of atypical presentations...
March 8, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28279484/doxycycline-versus-prednisolone-as-an-initial-treatment-strategy-for-bullous-pemphigoid-a-pragmatic-non-inferiority-randomised-controlled-trial
#8
Hywel C Williams, Fenella Wojnarowska, Gudula Kirtschig, James Mason, Thomas R Godec, Enno Schmidt, Joanne R Chalmers, Margaret Childs, Shernaz Walton, Karen Harman, Anna Chapman, Diane Whitham, Andrew J Nunn
BACKGROUND: Bullous pemphigoid is a blistering skin disorder with increased mortality. We tested whether a strategy of starting treatment with doxycycline gives acceptable short-term blister control while conferring long-term safety advantages over starting treatment with oral corticosteroids. METHODS: We did a pragmatic, multicentre, parallel-group randomised controlled trial of adults with bullous pemphigoid (three or more blisters at two or more sites and linear basement membrane IgG or C3)...
March 6, 2017: Lancet
https://www.readbyqxmd.com/read/28279483/doxycycline-a-first-line-treatment-for-bullous-pemphigoid
#9
Henry J Grantham, Deborah D Stocken, Nick J Reynolds
No abstract text is available yet for this article.
March 6, 2017: Lancet
https://www.readbyqxmd.com/read/28273946/dysregulation-of-mcd46-and-scd46-contribute-to-the-pathogenesis-of-bullous-pemphigoid
#10
Pei Qiao, Erle Dang, Tianyu Cao, Hui Fang, Jieyu Zhang, Hongjiang Qiao, Gang Wang
Bullous pemphigoid (BP) is an autoimmune bullous disease caused by autoantibodies against BP180 in the epidermal basement membrane. Autoantibody-mediated complement activation is an important process in BP pathogenesis. CD46, a crucial complement regulatory protein in the complement activation, has been reported to be involved in several autoimmune diseases. In the present study, we investigated whether CD46 plays a role in BP development. We found that sCD46 expression was significantly increased in the serum and blister fluids of BP patients and correlated with the levels of anti-BP180 NC16A antibody and C3a...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28261030/neurodegenerative-disorders-bullous-pemphigoid-and-psoriasis-a-comparative-study-in-ethnic-poles-indicates-that-parkinson-s-disease-is-more-relevant-to-bullous-pemphigoid
#11
Paweł Bartkiewicz, Justyna Gornowicz-Porowska, Paweł P Pietkiewicz, Anna Świrkowicz, Monika Bowszyc-Dmochowska, Marian Dmochowski
INTRODUCTION: Bullous pemphigoid (BP) is an autoimmune blistering dermatosis of the elderly with autoimmunity to hemidesmosomal proteins, BP180 and BP230, which are expressed also in neuronal tissue. AIM: The aim here was to retrospectively compare the prevalence of neurodegenerative disorders (ND), particularly Parkinson's disease (PD), unspecified conditions manifesting as dementia and stroke, in two groups of ethnic Poles, with BP and with psoriasis (Ps), in order to obtain data whether BP is more prone to coexist with ND than Ps in the elderly...
February 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28261028/accuracy-of-molecular-diagnostics-in-pemphigus-and-bullous-pemphigoid-comparison-of-commercial-and-modified-mosaic-indirect-immunofluorescence-tests-as-well-as-enzyme-linked-immunosorbent-assays
#12
Justyna Gornowicz-Porowska, Agnieszka Seraszek-Jaros, Monika Bowszyc-Dmochowska, Elżbieta Kaczmarek, Paweł Pietkiewicz, Paweł Bartkiewicz, Marian Dmochowski
INTRODUCTION: Pemphigus and bullous pemphigoid (BP) are identified by autoantibodies (abs) against desmoglein 1, 3 (DSG1/3) and BP180/BP230, respectively. A novel mosaic to indirect immunofluorescence (IIF) using purified BP180 recombinant proteins spotted on slide and transfected cells expressing BP230, DSG1, DSG3 is available. The commercial (IgG detection) and modified (IgG4 detection) mosaic for indirect immunofluorescence (IIFc - IIF commercial, IIFm - IIF modified) and IgG ELISAs were evaluated in pemphigus and bullous pemphigoid (BP) molecular diagnostics...
February 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28256743/non-bullous-lesions-as-the-first-manifestation-of-bullous-pemphigoid-a-retrospective-analysis-of-181-cases
#13
Yu Zhang, Yang Luo, Yue Han, Rong Tian, Wei Li, Xu Yao
The aim of the present study was to explore the clinical and histopathological characteristics and treatment of patients with bullous pemphigoid (BP) that initially manifested as non-bullous lesions and provide information for early diagnosis and improved treatment. Medical records of 491 cases of BP were collected. The clinical and histopathological characteristics, treatment and outcomes of patients who initially presented with non-bullous lesions (prodromal BP, PBP) were analyzed and compared with those from patients who initially presented with bullous lesions (classical BP, cBP)...
March 3, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28251900/immunotherapy-related-skin-toxicity-bullous-pemphigoid-in-a-lung-adenocarcinoma-patient-treated-with-the-anti-pdl1-antibody-atezolizumab
#14
Irene Russo, Giorgia Sacco, Stefano Frega, Valentina Polo, Giulia Pasello, Mauro Alaibac
No abstract text is available yet for this article.
March 1, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28247089/bullous-pemphigoid-a-review-of-its-diagnosis-associations-and-treatment
#15
REVIEW
Philippe Bernard, Frank Antonicelli
Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease in Western countries, and typically affects the elderly. BP is immunologically characterized by tissue-bound and circulating autoantibodies directed against either the BP antigen 180 (BP180, or BPAG2) or the BP antigen 230 (BP230, or BPAG1e), or even both, which are components of hemidesmosomes involved in the dermal-epidermal cohesion. Risk factors for BP include old age, neurologic diseases (dementia, Parkinson's disease, cerebrovascular disease), and some particular drugs, including loop diuretics, spironolactone and neuroleptics...
February 28, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28242091/-dermatoses-and-herpes-superinfection-a-retrospective-study-of-34%C3%A2-cases
#16
V Seta, F Fichel, J-F Méritet, S Bouam, N Franck, M-F Avril, N Dupin
BACKGROUND: Although varicelliform Kaposi eruption is a well-known complication of dermatoses, it has not been widely investigated. AIM: To investigate features of dermatoses and herpes superinfection in patients hospitalized in a dermatology department. PATIENTS AND METHODS: We performed a single-centre, retrospective study between 2008 and 2014 that included cases of Kaposi varicelliform eruptions defined by positive PCR of an unconventional site of herpetic recurrence in a setting of active dermatitis...
March 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28241331/gabapentin-induced-bullous-pemphigoid
#17
Avram Flamm, Sarina Sachdev, Francois Dufresne
Bullous pemphigoid is an autoimmune blistering dermatosis with separation of the epidermis from the dermis. This disease process is common among elderly patients and manifests with subepidermal vesicles and tense bullae. Patients with bullous pemphigoid are more likely to have also received a previous diagnosis of a neurologic disorder. Gabapentin is an antiepileptic that is used to manage neuropathic pain. The authors describe, to their knowledge, the first report of gabapentin-induced bullous pemphigoid in an elderly man with no history of rashes or reactions to other medications...
March 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28238716/bullous-pemphigoid-extensive-esophageal-involvement
#18
R Gaspar, P Moutinho-Ribeiro, G Macedo
No abstract text is available yet for this article.
February 23, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28228112/three-case-reports-of-post-immunization-and-post-viral-bullous-pemphigoid-looking-for-the-right-trigger
#19
Luca Baroero, Paola Coppo, Laura Bertolino, Stefano Maccario, Francesco Savino
BACKGROUND: Bullous pemphigoid (BP) is a blistering skin disorder infrequent in infancy and rarely reported in medical literature. CASE PRESENTATION: Here we describe three cases of BP which were referred to our department in the last 15 years. Two of them developed an eruption of bullous lesions just a few days after vaccination for diphtheria, tetanus, pertussis, poliomyelitis, hepatitis B and Haemophilus influenzae B. The third patient developed the same blistering lesions shortly after herpetic stomatitis...
February 23, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28222231/two-cases-of-anti-programmed-cell-death-1-associated-bullous-pemphigoid-like-disease-and-eruptive-keratoacanthomas-featuring-combined-histopathology
#20
Justin P Bandino, David M Perry, Christina E Clarke, Richard M Marchell, Dirk M Elston
Programmed cell death protein 1 (PD-1) inhibitors (pembrolizumab, nivolumab) are novel immunotherapies revolutionizing the management of advanced malignancy with an improved adverse effect profile, yet the immune-related side effects are still being characterized.(1,2) We report the unique concurrence of bullous pemphigoid-like disease (BP) with keratoacanthomas and squamous cell carcinomas in two patients receiving anti-PD-1 immunotherapy for metastatic melanoma. This article is protected by copyright. All rights reserved...
February 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
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