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cervical screening

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https://www.readbyqxmd.com/read/29229428/not-all-nucleic-acid-tests-are-equal-only-those-calibrated-to-detect-high-grade-lesions-matter-for-cervical-screening-authors-response
#1
Lena de Thurah, Jesper Bonde, Janni Uyen Hoa Lam, Matejka Rebolj
No abstract text is available yet for this article.
December 8, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29228452/establishment-and-analysis-of-the-prediction-model-for-cervical-squamous-cell-carcinoma
#2
Y-H Zhou, W-F Fan, J Deng, H-L Xi
OBJECTIVE: This study aimed to construct a prediction model for cervical squamous cell carcinoma and evaluate its accuracy in diagnosing cervical squamous cell carcinoma. PATIENTS AND METHODS: Fifty patients with initially histopathologically confirmed cervical squamous cell carcinoma and 150 patients with initially histopathologically confirmed cervical intraepithelial neoplasia (CIN) were enrolled. The high-risk human papillomavirus (HR-HPV) infection, human telomerase mRNA component (hTERC) gene and cell-myc (c-myc) gene amplification, and minichromosome maintenance protein 5 (MCM5) protein expression were detected...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29228289/clinical-practice-guideline-for-physical-therapy-assessment-and-treatment-in-patients-with-nonspecific-neck-pain
#3
Jasper D Bier, Wendy G M Scholten-Peeters, J Bart Staal, Jan Pool, Maurits W van Tulder, Emmylou Beekman, Jesper Knoop, Guus Meerhoff, Arianne P Verhagen
The Royal Dutch Society for Physical Therapy (KNGF) issued a clinical practice guideline for physical therapists that addresses the assessment and treatment of patients with nonspecific neck pain, including cervical radiculopathy, in Dutch primary care. Recommendations were based on a review of published systematic reviews.During the intake, the patient is screened for serious pathologies and corresponding patterns. Patients with cervical radiculopathy can be included or excluded through corresponding signs and symptoms and possibly diagnostic tests (Spurling test, traction/distraction test, and Upper Limb Tension Test)...
December 4, 2017: Physical Therapy
https://www.readbyqxmd.com/read/29228030/logistic-regression-analysis-of-conventional-ultrasonography-strain-elastosonography-and-contrast-enhanced-ultrasound-characteristics-for-the-differentiation-of-benign-and-malignant-thyroid-nodules
#4
Tiantian Pang, Leidan Huang, Yingyuan Deng, Tianfu Wang, Siping Chen, Xuehao Gong, Weixiang Liu
The aim of the study is to screen the significant sonographic features by logistic regression analysis and fit a model to diagnose thyroid nodules. A total of 525 pathological thyroid nodules were retrospectively analyzed. All the nodules underwent conventional ultrasonography (US), strain elastosonography (SE), and contrast -enhanced ultrasound (CEUS). Those nodules' 12 suspicious sonographic features were used to assess thyroid nodules. The significant features of diagnosing thyroid nodules were picked out by logistic regression analysis...
2017: PloS One
https://www.readbyqxmd.com/read/29223961/a-systematic-review-and-meta-analysis-of-studies-evaluating-the-performance-of-point-of-care-tests-for-human-papillomavirus-screening
#5
REVIEW
Helen Kelly, Philippe Mayaud, Michel Segondy, Nitika Pant Pai, Rosanna W Peeling
BACKGROUND: High-risk human papillomavirus (HPV) is a necessary cause of high-grade cervical intraepithelial neoplasia (grade 2 or higher, CIN2+). Simplified and rapid HPV DNA assays designed for use in resource-limited settings have recently become available. METHODS: We performed a systematic review and meta-analysis by searching Medline, Embase, Global Health and CINAHL databases for studies from 1 January 2004 to 25 February 2017 that reported the performance of careHPV or OncoE6 for the detection of histological CIN2+ in cervical cancer screening...
December 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29223960/systematic-reviews-of-point-of-care-tests-for-the-diagnosis-of-urogenital-chlamydia-trachomatis-infections
#6
REVIEW
Helen Kelly, Cordelia E M Coltart, Nitika Pant Pai, Jeffrey D Klausner, Magnus Unemo, Igor Toskin, Rosanna W Peeling
BACKGROUND: WHO estimates that 131 million new cases of urogenital Chlamydia trachomatis (CT) infections occur globally every year. Most infections are asymptomatic. Untreated infection in women can lead to severe complications. Screening and treatment of at-risk populations is a priority for prevention and control. OBJECTIVES: To summarise systematic reviews of the performance characteristics of commercially available point-of-care tests (POCT) for screening and diagnosis of urogenital CT infection...
December 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29223959/performance-and-operational-characteristics-of-point-of-care-tests-for-the-diagnosis-of-urogenital-gonococcal-infections
#7
REVIEW
Rebecca J Guy, Louise M Causer, Jeffrey D Klausner, Magnus Unemo, Igor Toskin, Anna M Azzini, Rosanna W Peeling
BACKGROUND: In 2012, there was an estimated 78 million new cases of gonorrhoea globally. Untreated infection may lead to reproductive and neonatal morbidity and facilitate HIV transmission. Diagnosis and treatment are a priority for control and prevention, yet use of point-of-care tests (POCTs) for Neisseria gonorrhoeae (NG) is limited. OBJECTIVES: To review the performance and operational characteristics of NG POCTs for diagnosis of urogenital gonorrhoea. METHODS: We compiled and synthesised findings from two separate systematic reviews which included evaluations published until August 2015...
December 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29223946/-quality-of-the-exo-endocervical-sampling-in-the-prevention-of-uterine-cervix-cancer
#8
Anabela A Angeleri, Lili B Díaz, Gisela Coliva, Fernando Guerra, Luis A Palaoro, Adriana E Rocher
Cervical and vaginal cytology, Papanicolaou test (PAP), is the most effective test for screening of preneoplastic lesions, and cervical cancer prevention. Its sensitivity goes from 50 to 98%, according to different statistics, and this variation is related to the sampling procedure. A satisfactory smear should be taken from the transformation zone, the junction between endocervix and exocervix. According to Bethesda, metaplastic and/or endocervical cells should be observed under the microscope. The traditional PAP smear includes an exo-endocervical sampling using the Ayre spatula; however, only near 50% of the smears are representative of the transformation zone...
2017: Medicina
https://www.readbyqxmd.com/read/29222045/challenges-in-risk-estimation-using-routinely-collected-clinical-data-the-example-of-estimating-cervical-cancer-risks-from-electronic-health-records
#9
Rebecca Landy, Li C Cheung, Mark Schiffman, Julia C Gage, Noorie Hyun, Nicolas Wentzensen, Walter K Kinney, Philip E Castle, Barbara Fetterman, Nancy E Poitras, Thomas Lorey, Peter D Sasieni, Hormuzd A Katki
Electronic health-records (EHR) are increasingly used by epidemiologists studying disease following surveillance testing to provide evidence for screening intervals and referral guidelines. Although cost-effective, undiagnosed prevalent disease and interval censoring (in which asymptomatic disease is only observed at the time of testing) raise substantial analytic issues when estimating risk that cannot be addressed using Kaplan-Meier methods. Based on our experience analysing EHR from cervical cancer screening, we previously proposed the logistic-Weibull model to address these issues...
December 5, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29221494/factors-associated-with-the-achievement-of-cervical-smears-by-general-practitioners
#10
Michaël Rochoy, Thibaut Raginel, Jonathan Favre, Estelle Soueres, Nassir Messaadi, Valérie Deken, Alain Duhamel, Christophe Berkhout
OBJECTIVE: Reliable data about general practitioners performing pap-tests are insufficient. A claim code for the achievement of pap-smears exists in France, but its use by general practitioners is not known. The main purpose of this study was to highlight independent factors associated with the achievement of pap-smears by the general practitioner (GP). We carried out a descriptive and analytic epidemiologic study in 347 GPs and their 244,889 patients, registered at the Health Care Insurance Fund of Flanders...
December 8, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29220062/community-academic-partnership-to-implement-a-breast-and-cervical-cancer-screening-education-program-in-puerto-rico
#11
Vivian Colón-López, Daisy González, Camille Vélez, Natalie Fernández-Espada, Alana Feldman-Soler, Kelly Ayala-Escobar, Alelí M Ayala-Marín, Marievelisse Soto-Salgado, William A Calo, Angela Pattatucci-Aragón, Marinilda Rivera-Díaz, María E Fernández
OBJECTIVE: To describe how a community-academic partnership between Taller Salud Inc., a community-based organization, and the Puerto Rico Community Cancer Control Outreach Program of the University of Puerto Rico was crucial in the adaptation and implementation of Cultivando La Salud (CLS), an evidencebased educational outreach program designed to increase breast and cervical cancer screening among Hispanic women living in Puerto Rico. This collaboration facilitated the review and adaptation of the CLS intervention to improve cultural appropriateness, relevance, and acceptability for Puerto Rican women...
December 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/29216918/effect-of-structured-training-programme-on-the-knowledge-and-behaviors-of-breast-and-cervical-cancer-screening-among-the-female-teachers-in-turkey
#12
Ayla Bayık Temel, Şafak Dağhan, Şenay Kaymakçı, Renginar Öztürk Dönmez, Zeynep Arabacı
BACKGROUND: Breast cancer and cervical cancer are the most common cancers among women in the world. Many studies on the early detection of cancer have been conducted among women worldwide, but few studies have been performed in the world on female teachers regarding breast self-examination (BSE), mammography (MMG) and Pap smear test (PST). As teachers interact with students, this could play an important role in health education and in developing healthy behavior such as cancer screening...
December 7, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29216880/cost-effectiveness-of-human-papilloma-virus-hpv-vaccination-in-nigeria-a-decision-analysis-using-pragmatic-parameter-estimates-for-cost-and-programme-coverage
#13
Obinna I Ekwunife, Stefan K Lhachimi
BACKGROUND: World Health Organisation recommends routine Human Papilloma Virus (HPV) vaccination for girls when its cost-effectiveness in the country or region has been duly considered. We therefore aimed to evaluate cost-effectiveness of HPV vaccination in Nigeria using pragmatic parameter estimates for cost and programme coverage, i.e. realistically achievable in the studied context. METHODS: A microsimulation frame-work was used. The natural history for cervical cancer disease was remodelled from a previous Nigerian model-based study...
December 8, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29216824/use-of-a-mixed-culture-strategy-to-isolate-halophilic-bacteria-with-antibacterial-and-cytotoxic-activity-from-the-manaure-solar-saltern-in-colombia
#14
Natalia Conde-Martínez, Alejandro Acosta-González, Luis E Díaz, Edisson Tello
BACKGROUND: Water evaporation in solar salterns creates salinity gradients that promote the adaptation of microbial species to different salinities. This competitive habitat challenges the metabolic capabilities of microorganisms and promotes alterations in their production of secondary metabolites. Thus, solar salterns are a potentially important source of new natural products. In Colombia, the most important and representative solar saltern is located in Manaure (La Guajira) in the north of Colombia...
December 8, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/29215711/triage-tools-for-detecting-cervical-spine-injury-in-pediatric-trauma-patients
#15
REVIEW
Annelie Slaar, M M Fockens, Junfeng Wang, Mario Maas, David J Wilson, J Carel Goslings, Niels Wl Schep, Rick R van Rijn
BACKGROUND: Pediatric cervical spine injury (CSI) after blunt trauma is rare. Nonetheless, missing these injuries can have severe consequences. To prevent the overuse of radiographic imaging, two clinical decision tools have been developed: The National Emergency X-Radiography Utilization Study (NEXUS) criteria and the Canadian C-spine Rule (CCR). Both tools are proven to be accurate in deciding whether or not diagnostic imaging is needed in adults presenting for blunt trauma screening at the emergency department...
December 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29215701/long-non-coding-rna-lncrna-rmst-in-triple-negative-breast-cancer-tnbc-expression-analysis-and-biological-roles-research
#16
Li Wang, Dequan Liu, Xingrao Wu, Yueqin Zeng, Lan Li, Yu Hou, Wenhui Li, Zhijie Liu
OBJECTIVE: Microarray showed that lncRNA RMST was differentially expressed in cervical cancer. Further experiments were conducted to detect the expression and biological function of RMST in triple-negative breast cancer (TNBC). METHODS: Microarray was used to screen the differentially expressed lncRNAs in TNBC. QRT-PCR was applied to uncover the expression of RMST in TNBC tissues. The cell viability of RMST-transfected TNBC cells were probed by CKK-8 assay and colony formation assay...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29215211/a-study-of-hormonal-effects-in-cervical-smear-samples-using-raman-spectroscopy
#17
Damien Traynor, Padraig Kearney, Ines Ramos, Cara M Martin, John J O'Leary, Fiona M Lyng
Raman spectroscopy is a powerful tool that has the potential to be used as a screening method for cervical cancer. It is a label free, low cost method providing a biochemical fingerprint of a given sample. The objective of this study was to address patient to patient variability contributed by hormonal effects due to the menstrual cycle, the use of hormone based contraceptives and the onset of menopause, and to determine if these changes would affect the ability to successfully identify dyskaryotic cells. Raman spectra were recorded from unstained ThinPrep cervical samples (45 cytology negative and 15 high grade dyskaryosis (high grade squamous intraepithelial lesion (SIL)) samples using a HORIBA Jobin Yvon XploRA™ system...
December 7, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29214758/comparison-of-four-human-papillomavirus-genotyping-methods-next-generation-sequencing-inno-lipa-electrochemical-dna-chip-and-nested-pcr
#18
Pornjarim Nilyanimit, Jira Chansaenroj, Witthaya Poomipak, Kesmanee Praianantathavorn, Sunchai Payungporn, Yong Poovorawan
BACKGROUND: Human papillomavirus (HPV) infection causes cervical cancer, thus necessitating early detection by screening. Rapid and accurate HPV genotyping is crucial both for the assessment of patients with HPV infection and for surveillance studies. METHODS: Fifty-eight cervicovaginal samples were tested for HPV genotypes using four methods in parallel: nested-PCR followed by conventional sequencing, INNO-LiPA, electrochemical DNA chip, and next-generation sequencing (NGS)...
March 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/29213299/cervical-cancer-patients-presentation-and-survival-in-the-only-oncology-referral-hospital-ethiopia-a-retrospective-cohort-study
#19
Muluken Gizaw, Adamu Addissie, Sefonias Getachew, Wondimu Ayele, Israel Mitiku, Ulrike Moelle, Tigist Yusuf, Mathias Begoihn, Mathewos Assefa, Ahmedin Jemal, Eva Johanna Kantelhardt
Background: Women infected with Human Immune Deficiency Virus (HIV) are assumed to be at higher risk of developing Cervical Cancer (CC). This is due to a rapid progression of pre-invasive to invasive lesions. However, evidences suggest, due to the availability of antiretroviral therapy (ART) and care services; an improved survival and treatment outcome of CC patients (CCPs) with HIV infection is expected. Objective: The aim of this study is to examine the clinical characteristics and survival of of CCPs registered at the radiotherapy center of Tikur Anbessa Specialized Hospital (TASH), Addis Ababa University, Ethiopia...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29212399/conservative-management-of-cin2-national-audit-of-british-society-for-colposcopy-and-cervical-pathology-members-opinion
#20
Madeleine Macdonald, John H F Smith, John A Tidy, Julia E Palmer
There is no doubt that organised cervical screening programmes have significantly reduced the rates of cervical cancer by detection and treatment of high-grade cervical intraepithelial neoplasia (CIN2, CIN3). National UK guidelines do not differentiate between CIN2 and CIN3 as separate entities and recommend treatment for both, although a degree of uncertainty exists regarding the natural history of CIN2. This national survey of British Society for Colposcopy and Cervical Pathology members aimed to assess attitudes towards conservative management (CM) of CIN2 in the UK and identify potential selection criteria...
December 6, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
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