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cervical screening

Bassel G Diebo, Jared C Tishelman, Samantha Horn, Gregory W Poorman, Cyrus Jalai, Frank A Segreto, Cole A Bortz, Michael C Gerling, Virginie Lafage, Andrew P White, James M Mok, Thomas D Cha, Robert K Eastlack, Kris E Radcliff, Carl B Paulino, Peter G Passias
Optimizing functional outcomes and disability status are essential for effective surgical treatment of cervical spine disorders. Mental impairment is common among patients with cervical spine complaints; yet little is known about the impact of baseline mental status with respect to overall patient-reported outcomes. This was a retrospective analysis of patients with cervical spondylosis with myelopathy(CM) or radiculopathy(CR: cervical disc herniation, stenosis, or spondylosis without myelopathy) at 2-year follow-ups...
June 12, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
P J Toliman, J M Kaldor, S G Badman, S Phillips, G Tan, J M L Brotherton, M Saville, A J Vallely, S N Tabrizi
OBJECTIVES: To compare the performance of self-collected vaginal (V) specimens with clinician-collected cervical (C) specimens for detection of high-risk human papillomavirus (hrHPV) and cervical disease using the Cepheid Xpert HPV, Roche Cobas 4800 HPV, and Hologic Aptima HPV assays. METHODS: Women aged 30-59 years (N=1005) were recruited at two clinics in Papua New Guinea, and provided specimens for testing at point-of-care using the Xpert HPV Test, and for subsequent testing using the Cobas HPV (n=981) and Aptima HPV (n=983) assays...
June 12, 2018: Clinical Microbiology and Infection
Y T Nejo, D O Olaleye, G N Odaibo
There is a great variation in the prevalence of cervical HPV infection worldwide with some of the highest rates being found in African women. Early onset of sexual activity (≤ 15 age), multiparity and sexual promiscuity have been recognized as some of the significant risk factors for HPV infection. In Nigeria, there is scarcity of data on the degree of relationship between these factors and the prevalence of HPV infection. Thus, this study was designed to determine the prevalence of genital HPV infection with its potential risk factors among women in Southwest Nigeria...
February 2018: Archives of basic and applied medicine
Alessandra Hermógenes Gomes Tobias, Aline Costa Vitalino, Mariana Trevisan Rezende, Renata Rocha E Rezende Oliveira, Wendel Coura-Vital, Rita Goreti Amaral, Cláudia Martins Carneiro
BACKGROUND: An objective of quality control for cervical cytopathology is reducing high rates of false-negative results of laboratory tests. Therefore, methods to review smears such as rapid prescreening and 100% rapid review, which have shown better performance detecting false-negative results, have been widely used. The performance of rapid prescreening and of 100% rapid review as internal quality control methods for cervical cytology examinations were evaluated. METHODS: During 24 months, 9318 conventional cervical cytology smears underwent rapid prescreening and routine screening...
June 15, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
Jose Candido Caldeira Xavier-Júnior, Deolino João Camilo-Júnior, Ana Paula Hehnes Guedes do Amaral Gardini, Solange Correa Garcia Pires D'ávilla, Neivio José Mattar
The Brazilian Cervical Cancer Screening Program recommends that women are screened between ages 25 and 69 years, with cervical smears every 3 years after two consecutive negative annual smears.[1] The high-risk HPV test is not available in Brazil and the screening is opportunistic, without invitation. In 10 years it is expected that every woman will receive three to four screening examinations.[1]. This article is protected by copyright. All rights reserved.
June 15, 2018: International Journal of Gynaecology and Obstetrics
Christos Parthenis, Periklis Panagopoulos, Niki Margari, Christine Kottaridi, Aris Spathis, Abraham Pouliakis, Stefanos Konstantoudakis, George Chrelias, Charalambos Chrelias, Nikolaos Papantoniou, Ioannis G Panayiotides, Sotirios Tsiodras
OBJECTIVES: To investigate STIs diagnosis with HPV infection and the presence of cytological changes of the cervix in a cohort of sexually active women in Greece. METHODS: Cervical cytology testing, molecular typing of HPV and other STIs was performed in 345 sexually active women aged between 18 and 45 years (33.2±7.2) visiting a gynaecology clinic for routine cervical screening. We investigated the association of HPV and STI detection with cytological findings...
June 11, 2018: International Journal of Infectious Diseases: IJID
José Gabriel Solís, Tomás Iván Briones-Torres
Background: Cervical cancer represents the second leading cause of malignant neoplasm mortality in women globally. Cervical cytology is the most important screening study. It is therefore of interest to know the prevalence of cytological alterations in the Mexican population. In this study the objective was to calculate the prevalence of intraepithelial lesion in cervical screening cytology. Methods: An observational, descriptive and cross-sectional study was developed; the sample was 379 patients from 21 to 64 years of age; we included patients who underwent cervical screening cytology registered in the Detección Oportuna de Cáncer Cervicouterino (DOC-CACU) program database...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
Ruchi Arun, Jai Prakash Singh, Shyam Bihari Gupta
Background: It is possible to prevent deaths due to cervical cancer through screening and treatment. Cervical cytology which is a standard screening tool in developed countries fails as a screening method in low-resource countries due to financial and technical constraints. Objective: To determine the prevalence of pre-malignant lesions of the cervix by VIA and Pap smear test among rural married women and to find out association of socio demographic factors with positive screening test results...
April 2018: Indian Journal of Community Medicine
Sang-Hyun Hwang, Hye Young Shin, Dong Ock Lee, Na Young Sung, Bomyee Lee, Do-Hoon Lee, Jae Kwan Jun
This pilot study sought to evaluate the feasibility of utilizing vaginal self-swabs and urine samples for HPV-based cervical cancer screening in 700 women who had undergone conventional Pap smear screening via the national cervical cancer program in Korea. The cobas 4800 HPV test was utilized to detect HPV in the self-samples. Pap smear results revealed three cases of atypical squamous cells of undetermined significance, 649 cases of negative for an intraepithelial lesion or malignancy, and 48 non-specific inflammatory findings...
June 13, 2018: Scientific Reports
Ann-Kathrin Schubert, Jeske J Smink, Mirko Arp, Jochen Ringe, Aldemar A Hegewald, Michael Sittinger
A discrimination of the highly specialised annulus fibrosus (AF) and nucleus pulposus (NP) cells in the mature human intervertebral disc (IVD) is thus far still not possible in a reliable way. The aim of this study was to identify molecular markers that distinguish AF and NP cells in human disc tissue using microarray analysis as a screening tool. AF and NP samples were obtained from 28 cervical discs. First, all samples underwent quality sorting using two novel scoring systems for small-sized disc tissue samples including macroscopic, haptic and histological evaluation...
June 13, 2018: International Journal of Molecular Sciences
Jata S Misra, Anand N Srivastava, Hem P Gupta
OBJECTIVE: Cytological screening was carried out in rural women of Lucknow West, India, through a camp approach to detect cervical cancer in its preinvasive phase and to see whether the primitive living conditions in the villages have any effect on the incidence of precancer and carcinoma of the cervix and the associated predisposing factors of cervical carcinogenesis. STUDY DESIGN: During a span of 4 years (May 2013 to March 2017), a total of 135 camps were organized under the auspice of Era's Lucknow Medical College and Hospital (Lucknow, India)...
June 13, 2018: Acta Cytologica
Xianxu Zeng, Xiaoan Zhang, Canyu Li, Xiaofang Wang, Jason Jerwick, Tao Xu, Yuan Ning, Yihong Wang, Linlin Zhang, Zhan Zhang, Yutao Ma, Chao Zhou
Cervical cancer remains the fourth most common cause of cancer worldwide and the third leading cause of cancer deaths for women in developing countries. Traditional screening tools, such as human papillomavirus and Pap tests, cannot provide results in real-time and cannot localize suspicious regions. Colposcopy-directed biopsies are invasive in nature and only a few sites of the cervix may be chosen for investigation. A non-invasive, label-free and real-time imaging method with a resolution approaching that of histopathology is desirable for early detection of the disease...
2018: Theranostics
Alex K Mezei, Heather N Pedersen, Stephen Sy, Catherine Regan, Sheona M Mitchell-Foster, Josaphat Byamugisha, Musa Sekikubo, Heather Armstrong, Angeli Rawat, Joel Singer, Gina S Ogilvie, Jane J Kim, Nicole G Campos
BACKGROUND: Cervical cancer is the leading cause of cancer death for women in Uganda, despite the potential for prevention through organised screening. Community-based self-collected human papillomavirus (HPV) testing has been proposed to reduce barriers to screening. OBJECTIVE: Our objective was to evaluate the cost-effectiveness of the Advances in Screening and Prevention of Reproductive Cancers (ASPIRE) trial, conducted in Kisenyi, Uganda in April 2014 (n=500)...
June 12, 2018: BMJ Open
Aleksander Celewicz, Marta Celewicz, Małgorzata Wężowska, Anita Chudecka-Głaz, Janusz Menkiszak, Elzbieta Urasińska
Cervical cancer is the third most common malignant neoplasm in women worldwide. HPV infection is the necessary factor for the cancer to develop. HPV DNA can be integrated into the genome of squamous epithelium and cause transcription of the viral oncoproteins and development of invasive cancer within 15-20 years. We assessed ICC co-expression of p16/Ki-67 proteins in smears collected from the uterine cervix and the association between p16/Ki-67 co-expression and cytologic and histologic results. Samples were collected from 93 women using liquid based cytology (LBC)...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
Uwadiae Obahiagbon, Joseph T Smith, Meilin Zhu, Benjamin A Katchman, Hany Arafa, Karen S Anderson, Jennifer M Blain Christen
An effective method of combating infectious diseases is the deployment of hand-held devices at the point-of-care (POC) for screening or self-monitoring applications. There is a need for very sensitive, low-cost and quantitative diagnostic devices. In this study, we present a low-cost, multiplexed fluorescence detection platform that has a high sensitivity and wide dynamic range. Our system features inexpensive 3 × 3 mm interference filters with a high stopband rejection, sharp transition edges, and greater than 90% transmission in the passband...
April 4, 2018: Biosensors & Bioelectronics
João Firmino-Machado, Sofia Varela, Romeu Mendes, Amélia Moreira, Nuno Lunet
No abstract text is available yet for this article.
June 9, 2018: Preventive Medicine
L I Cardoso Filho, S B N Tavares, M L B Siqueira, E N Dos Passos, N L A S Araújo, J M A Martins, A A Ribeiro, S H R Dos Santos
INTRODUCTION: To evaluate the internal quality control indicators and quality management programme in a university cytopathology laboratory. METHODS: All results of conventional cervical smears tests (taken from the SISCAN, the Brazilian cervical cancer screening system) of women aged ≥15 years at the time of Papanicolaou smear specimen collection during January 2007-December 2014 were included. The final results of the cytopathology were classified in accordance with the Bethesda System...
June 12, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
Wenhui Li, Dalin Shi, Ruhan Jia, Jing Yang, Yanyan Zhang, Wei Chen, Yuewu Han
An in vitro synthesized random ssDNA library was subjected to 12 rounds of selection against anti-screening cells and sieving cells by SELEX. Normal and inflammatory cervical exfoliation cells were selected as anti-screening cells, and the cervical exfoliation cells of low-grade squamous intraepithelial lesion (CIN1), high-grade squamous intraepithelial lesion (CIN2, CIN3) and cervical carcinoma were selected as sieving cells during the screening process. Then, the highly specific aptamer CIN-Ap4 was established by the analysis of the specificity, affinity and cell immunofluorescence, which can be used as biomarker for Cervical Intraepithelial Neoplasia...
May 25, 2018: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
Megan Swanson, Stefanie Ueda, Lee-May Chen, Megan J Huchko, Carol Nakisige, Jane Namugga
There is significant disparity in the prevalence of cervical cancer globally, with low- and middle-income countries (LMICs) shouldering a disproportionate share of disease incidence and an even greater proportion of morbidity and mortality. Available resources for diagnosis, treatment and palliation of cervical cancer are inversely related to per capita income. While prevention and screening remain public health priorities, given the large number of women affected by cervical cancer, expanding treatment capacity should be included in any evidence-based intervention plan...
May 2018: Gynecologic Oncology Reports
Spencer G Kuper, Victoria C Jauk, David M George, Rodney K Edwards, Jeff M Szychowski, Sara E Mazzoni, Michelle J Wang, Pamela Files, Alan T Tita, Akila Subramaniam, Lorie M Harper
OBJECTIVE: To assess whether outpatient cervical ripening with a transcervical Foley catheter in parous women undergoing elective induction of labor shortens the total duration of time from admission to the labor ward until delivery. METHODS: We performed an open-label randomized controlled trial at a single academic center in parous women at 39 weeks of gestation or greater with a cervix 3 cm or less dilated, or, if 2-3 cm dilated, less than 80% effaced and reassuring fetal heart rate monitoring (defined as moderate variability with a normal baseline and absence of decelerations)...
June 6, 2018: Obstetrics and Gynecology
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