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https://www.readbyqxmd.com/read/29444273/prevalence-and-determinants-in-cytology-testing-for-cervical-cancer-screening-in-spain-2006-14
#1
Ana I Cobo-Cuenca, María-Aurora Rodríguez-Borrego, Pedro Hidalgo-Lópezosa, Pedro M Rodríguez-Muñoz, Manuela Martins, Juan M Carmona-Torres
Background: Cervical cancer has decreased in developed countries thanks to cytology screening programmes. The aims of this study were To analyse the frequency and evolution of performing cytology tests and to determine the variables that influence their use. Methods: Cross-sectional study of non-institutionalized women who participated in the national health survey (2006, 2011/12) and the European Health Survey in Spain (2009, 2014). Study variables: cytology-testing, time since last cytology-test, reason for performing the test, age, nationality, marital status, social status, education level and place of residence...
February 12, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29444073/projected-future-impact-of-hpv-vaccination-and-primary-hpv-screening-on-cervical-cancer-rates-from-2017-2035-example-from-australia
#2
Michaela T Hall, Kate T Simms, Jie-Bin Lew, Megan A Smith, Marion Saville, Karen Canfell
BACKGROUND: Many countries are transitioning from cytology-based to longer-interval HPV screening. Trials comparing HPV-based screening to cytology report an increase in CIN2/3 detection at the first screen, and longer-term reductions in CIN3+; however, population level year-to-year transitional impacts are poorly understood. We undertook a comprehensive evaluation of switching to longer-interval primary HPV screening in the context of HPV vaccination. We used Australia as an example setting, since Australia will make this transition in December 2017...
2018: PloS One
https://www.readbyqxmd.com/read/29442221/dual-stained-cervical-cytology-and-histology-with-claudin-1-and-ki67
#3
Tímea Szekerczés, Ádám Galamb, Adrienn Kocsis, Márta Benczik, Tibor Takács, Attila Martonos, Balázs Járay, András Kiss, Csaba Jeney, Miklós Nyíri, Zsuzsa Schaff, Gábor Sobel
Several biomarkers are in use to improve the sensitivity and specificity of cervical cancer screening. Previously, increased expression of tight junction protein claudin-1 (CLDN1) was detected in premalignant and malignant cervical lesions and applied for cytology screening. To improve the specificity, a double immunoreaction with CLDN1/Ki67 was developed in the recent study. Parallel p16/Ki67 (CINtec® PLUS) and CLDN1/Ki67 dual-stained cytology and histology were performed and compared. p16/Ki67 immunoreaction showed positivity in 317 out of 1596 smears with negativity in 1072 and unacceptable reactions in 207 samples...
February 13, 2018: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29441700/knowledge-about-cervical-cancer-and-barriers-toward-cervical-cancer-screening-among-hiv-positive-women-attending-public-health-centers-in-addis-ababa-city-ethiopia
#4
Saba Shiferaw, Adamu Addissie, Muluken Gizaw, Selamawit Hirpa, Wondimu Ayele, Sefonias Getachewe, Eva J Kantelhardt, Mathewos Assefa, Ahmedin Jemal
Screening rate for cervical cancer among HIV-infected women and among women overall is low in Ethiopia despite the high burden of the disease and HIV infection, which increases cervical cancer risk. In this paper, we assessed knowledge about cervical cancer symptoms, prevention, early detection, and treatment and barriers to screening among HIV-positive women attending community health centers for HIV-infection management in Addis Ababa. A cross-sectional survey of 581 HIV-positive women aged 21-64 years old attending 14 randomly selected community health centers without cervical cancer screening service in Addis Ababa...
February 14, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29440214/-it-has-saved-thousands-of-lives-so-why-change-it-content-analysis-of-objections-to-cervical-screening-programme-changes-in-australia
#5
Helena M Obermair, Rachael H Dodd, Carissa Bonner, Jesse Jansen, Kirsten McCaffery
OBJECTIVES: The incidence and mortality of cervical cancer have halved since introduction of the Australian cervical screening programme in 1991, involving 2-yearly Pap smears from ages 18-69 years. In 2017, the programme changed to 5- yearly primary human papillomavirus (HPV) testing for women aged 25-74 years. This study investigated reasons for opposition to the renewed screening programme within the open-ended comments of an online petition, 'Stop May 1st Changes to Pap Smears-Save Women's Lives', opposing the changes, which received over 70 000 signatures and almost 20 000 comments...
February 13, 2018: BMJ Open
https://www.readbyqxmd.com/read/29439604/acceptability-of-non-speculum-clinician-sampling-for-cervical-screening-in-older-women-a-qualitative-study
#6
Madeleine Freeman, Jo Waller, Peter Sasieni, Anita Ww Lim, Laura Av Marlow
Objectives One reason that women over age 50 report avoiding cervical screening is increased discomfort postmenopause. This study aimed to explore the acceptability of human papillomavirus testing on clinician-collected vaginal samples without a speculum ('non-speculum') for cervical screening among older women. Methods Thirty-eight women in England aged 50-64 with a range of cervical screening experience ('up-to-date' n = 17, 'overdue screening' n = 18, 'never screened' n = 3) were identified via a recruitment agency...
January 1, 2018: Journal of Medical Screening
https://www.readbyqxmd.com/read/29439180/secondary-neoplasms-of-the-female-lower-genital-tract-after-hematopoietic-cell-transplantation
#7
REVIEW
Howard A Chang, Saro H Armenian, Thanh H Dellinger
Hematopoietic cell transplantation (HCT) results in long-term survival (≥10 years) in 85% of patients who survive transplant-related complications within the first 2 years posttransplant. Transplant survivors, however, are at an increased risk of chronic health conditions compared with the general population, including the emergence of secondary malignant neoplasms. In particular, female transplant survivors may face a greater risk of lower genital tract (cervical, vulvar, or vaginal) neoplasms due to chronic immune dysregulation in the peritransplant and posttransplant environment...
February 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29438367/randomised-study-shows-that-repeated-self-sampling-and-hpv-test-has-more-than-two-fold-higher-detection-rate-of-women-with-cin2-histology-than-pap-smear-cytology
#8
Inger Gustavsson, Riina Aarnio, Malin Berggrund, Julia Hedlund-Lindberg, Ann-Sofi Strand, Karin Sanner, Ingrid Wikström, Stefan Enroth, Matts Olovsson, Ulf Gyllensten
BACKGROUND: This randomised study compared the detection rate of cervical intraepithelial neoplasia-positive (CIN2+) based on histology in women performing repeated self-sampling of vaginal fluid (VF) for human papillomavirus (HPV) test with a control group following the ordinary screening by Pap smear cytology. METHODS: 36390 women aged 30-49 years scheduled for invitation to organised screening were randomised in two groups, one to perform self-sampling of VF for HPV test (n=17 997, HPV arm) and the other group to perform screening by PAP smear cytology (n=18 393, control arm)...
February 13, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29437696/clinical-outcomes-after-conservative-management-of-cervical-intraepithelial-neoplasia-grade-2-cin2-in-women-ages-21-39-years
#9
Michelle I Silver, Julia C Gage, Mark Schiffman, Barbara Fetterman, Nancy E Poitras, Thomas Lorey, Li C Cheung, Hormuzd A Katki, Alexander Locke, Walter K Kinney, Philip E Castle
Cervical intraepithelial neoplasia grade 2 (CIN2) frequently regresses, is typically slow-growing, and rarely progresses to cancer. Some women forgo immediate treatment, opting for conservative management (heightened surveillance with cytology and colposcopy), to minimize overtreatment and increased risk of obstetric complications; however, there are limited data examining clinical outcomes in these women. We performed a retrospective cohort analysis of younger women diagnosed with initially untreated CIN1/2, CIN2 and CIN2/3 lesions at Kaiser Permanente Northern California between 2003-2015...
February 5, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29436615/identification-and-validation-of-the-role-of-matrix-metalloproteinase-1-in-cervical-cancer
#10
Run Tian, Xiaofang Li, Yan'e Gao, Yue Li, Pei Yang, Kunzheng Wang
Lymph node (LN) metastasis at an early stage of cervical cancer is often an indicator of poor prognosis and is critical for subsequent adjuvant therapy. The current study aimed to identify aberrant gene signatures and biomarkers of metastasis for patients with cervical cancer. RNA-sequencing data of 132 LN negative (N0) and 60 LN positive (N1) cervical cancer samples obtained from The Cancer Genome Atlas database were analyzed. Differentially expressed genes were identified using R packages 'edgeR' and 'limma'...
February 7, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29436238/the-incremental-role-of-trait-emotional-intelligence-on-perceived-cervical-screening-barriers
#11
Sebastiano Costa, Nadia Barberis, Rosalba Larcan, Francesca Cuzzocrea
Researchers have become increasingly interested in investigating the role of the psychological aspects related to the perception of cervical screening barriers. This study investigates the influence of trait EI on perceived cervical screening barriers. Furthermore, this study investigates the incremental validity of trait EI beyond the Big Five, as well as emotion regulation in the perceived barrier towards the Pap test as revealed in a sample of 206 Italian women that were undergoing cervical screening. Results have shown that trait EI is negatively related to cervical screening barriers...
February 13, 2018: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/29435721/selection-and-identification-of-novel-peptides-specifically-targeting-human-cervical-cancer
#12
Xiaomin Liu, Jingwen Peng, Jie He, Qiaoran Li, Jianbin Zhou, Xiaoqiu Liang, Shengsong Tang
Cervical cancer is the second most commonly diagnosed cancer and the third leading cause of cancer deaths among females in underdeveloped countries. This study aimed to identify several novel cervical cancer-specific targeting peptides (CSPs) to provide new methods for the effective diagnosis and treatment of cervical cancer. Peptide library screening in vivo was performed on human cervical cancer xenografts with Ph.D.™-12 and C7C phage display peptide libraries. Two specific peptide sequences (GDALFSVPLEVY and KQNLAEG), which were enriched in tumors, were screened, and respectively, named CSP-GD and CSP-KQ through three rounds of biopanning...
February 12, 2018: Amino Acids
https://www.readbyqxmd.com/read/29433700/a-literature-review-of-cervical-cancer-screening-in-transgender-men
#13
REVIEW
Kayla C Gatos
Most female-to-male (FTM) transgender men retain their cervixes and need comprehensive sexual health care, including cervical cancer screening. According to the literature, FTM individuals obtain cervical cancer screening less frequently and are less likely to be up to date on their Pap tests compared with cisgender women. Misinformation related to human papillomavirus and cervical cancer risk was noted for health care providers and FTM individuals. Absence of transgender-specific guidelines or trained health care providers presents barriers to cervical cancer screening for FTM individuals, and further research is indicated to develop comprehensive guidelines unique to the needs and experiences of this population...
February 2018: Nursing for Women's Health
https://www.readbyqxmd.com/read/29433016/self-sampling-with-hpv-mrna-analyses-from-vagina-and-urine-compared-with-cervical-samples
#14
Katrin Christine Asciutto, Avalon Ernstson, Ola Forslund, Christer Borgfeldt
BACKGROUND: In order to increase coverage in the organized cervical screening program, self-sampling with HPV analyses has been suggested. OBJECTIVES: The aim was to compare human papillomavirus (HPV) mRNA detection in vaginal and urine self-collected samples with clinician-taken cervical samples and the corresponding clinician-taken histological specimens. STUDY DESIGN: Self-collected vaginal, urine and clinician-taken cervical samples were analyzed from 209 women with the Aptima mRNA assay (Hologic Inc, MA, USA)...
February 6, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29432549/incidence-mortality-and-determinants-of-survival-from-cervical-cancer-in-northwest-russia-a-registry-based-cohort-study
#15
Andrej M Grjibovski, Daria Dubovichenko, Shynar Saduakassova, Gulmira Zhatkanbayeva, Gulzhakhan Omarova, Gulnar Shalgumbayeva, Lyudmila Valkova, Mikhail Y Valkov
Background: Cervical cancer is the third most common cancer among women. The evidence from Russia, however, is scarce. We studied the incidence of and mortality from cervical cancer in northwest Russia, and assessed determinants of survival among cervical cancer patients. Methods: This registry-based historical cohort study obtained data on all primary cases of cervical cancer in the Arkhangelsk region in 2000-2014 from the Arkhangelsk Regional Cancer Registry. One- and 5-y survival was calculated using life tables...
February 8, 2018: International Health
https://www.readbyqxmd.com/read/29428790/management-of-cervical-premalignant-lesions
#16
REVIEW
Partha Basu, Katayoun Taghavi, Shang-Ying Hu, Sushma Mogri, Smita Joshi
Treatment of cervical premalignant lesions (cervical intraepithelial neoplasia; CIN) of different grades is very effective, simple, and safe. The entire transformation zone of the cervix needs to be treated either by an ablative technique (cryotherapy or thermal ablation) or an excisional technique (large loop excision of transformation zone or cold knife conization); the choice of treatment depends on the size and location of the lesion and the type of the transformation zone. The cure rate after ablative treatment of high-grade CIN may be little lower than that after excisional treatment...
January 11, 2018: Current Problems in Cancer
https://www.readbyqxmd.com/read/29427549/linking-type-2-diabetes-and-gynecological-cancer-an-introductory-overview
#17
REVIEW
Emanuela Anastasi, Tiziana Filardi, Sara Tartaglione, Andrea Lenzi, Antonio Angeloni, Susanna Morano
Type 2 diabetes (T2D) is a chronic disease with a growing prevalence and a leading cause of death in many countries. Several epidemiological studies observed an association between T2D and increased risk of many types of cancer, such as gynecologic neoplasms (endometrial, cervical, ovarian and vulvar cancer). Insulin resistance, chronic inflammation and high free ovarian steroid hormones are considered the possible mechanisms behind this complex relationship. A higher risk of endometrial cancer was observed in T2D, even though this association largely attenuated after adjusting for obesity...
February 10, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29426562/a-nurse-led-cervical-screening-clinic-in-primary-care
#18
Ghislaine Young
Eliza is a practice nurse in a large general practice in England. She is trained in cancer screening and health promotion as well as chronic disease management. Today patients are consulting with her for their cervical smear test.
February 2018: Revue de L'infirmière
https://www.readbyqxmd.com/read/29426344/implementation-strategies-to-improve-cervical-cancer-prevention-in-sub-saharan-africa-a-systematic-review
#19
REVIEW
Lauren G Johnson, Allison Armstrong, Caroline M Joyce, Anne M Teitelman, Alison M Buttenheim
BACKGROUND: Developed countries, such as the USA, have achieved significant decreases in cervical cancer burden since the introduction of Pap smear-based programs in the 1960s. Due to implementation barriers and limited resources, many countries in sub-Saharan Africa (SSA) have been unable to attain such reductions. The purpose of this review is to evaluate implementation strategies used to improve the uptake and sustainability of cervical cancer prevention programs in SSA. METHODS: A reviewer (LJ) independently searched PubMed, Ovid/MEDLINE, Scopus, and Web of Science databases for relevant articles with the following search limits: English language, peer reviewed, and published between 1996 and 2017...
February 9, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29425225/an-integrated-strategy-for-improving-contrast-durability-and-portability-of-a-pocket-colposcope-for-cervical-cancer-screening-and-diagnosis
#20
Christopher T Lam, Jenna Mueller, Betsy Asma, Mercy Asiedu, Marlee S Krieger, Rhea Chitalia, Denali Dahl, Peyton Taylor, John W Schmitt, Nimmi Ramanujam
INTRODUCTION: We have previously developed a portable Pocket Colposcope for cervical cancer screening in resource-limited settings. In this manuscript we report two different strategies (cross-polarization and an integrated reflector) to improve image contrast levels achieved with the Pocket Colposcope and evaluate the merits of each strategy compared to a standard-of-care digital colposcope. The desired outcomes included reduced specular reflection (glare), increased illumination beam pattern uniformity, and reduced electrical power budget...
2018: PloS One
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