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https://www.readbyqxmd.com/read/29594199/hemospray-for-recurrent-esophageal-band-ulcer-bleeding
#1
Uday A Sanglodkar, Dinesh Jothimani, Mohamed Rela
Rebleeding after initially successful endoscopic variceal ligation (EVL) occurs in 20-60% of patients, most commonly from band ulcers, and is associated with 20-50% mortality. Although band ulcer bleeding has been treated in a number of different ways, no single therapeutic intervention has shown a clear benefit. Hemospray (Cook Medical, Winston-Salem, North Carolina, USA) is a relatively new non-contact hemostatic modality used in the management of bleeding peptic ulcers. It is a nano-powder that can be sprayed over a larger mucosal area...
March 2018: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29570557/the-use-and-safety-of-a-novel-haemostatic-spray-in-the-endoscopic-management-of-acute-non-variceal-upper-gastrointestinal-bleeding-in-children
#2
Mike Thomson, Arun Urs, Priya Narula, Prithviraj Rao, Dalia Belsha
AIMS AND BACKGROUND: Advanced endo-haemostatic technique performance and experience is extremely variable in distribution amongst pediatric endoscopists. Haemostatic spray (Hemospray®), a novel endo-haemostatic topically applied powder has the advantage of extreme ease of use and; hence may lower the threshold of competency required by the endoscopist thereby potentially reducing mortality. The aim of the study is to prospectively evaluate the efficacy and the safety of haemostatic spray in paediatric patients with AUGIB...
March 22, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29405446/role-of-hemostatic-powders-in-the-management-of-lower-gastrointestinal-bleeding-a-review
#3
REVIEW
Fadi H Mourad, Rupert W Leong
Despite the recent advances in endoscopic hemostatic techniques, the management of lower gastrointestinal bleeding could be sometimes challenging. Hemostatic powders such as Hemospray, EndoClot, and Ankaferd Blood Stopper have found their way into digestive endoscopy and are licenced in many countries especially for use in upper gastrointestinal bleeding. We reviewed the literature on the use of these hemostatic powders in different situations in lower gastrointestinal bleeding and looked at the success rate and rebleeding rate...
February 6, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29158179/prognostic-factors-affecting-outcomes-in-patients-with-malignant-gi-bleeding-treated-with-a-novel-endoscopically-delivered-hemostatic-powder
#4
Rapat Pittayanon, Rungsun Rerknimitr, Alan Barkun
BACKGROUND AND AIMS: Endoscopic hemostatic techniques remain poorly effective for GI tumor bleeding. We assessed Tc-325 (Hemospray, Cook Medical, Bloomington, Ind, USA) for this indication and determined possible predictors of decreased recurrent bleeding and improved 6-month survival in affected patients. METHODS: This retrospective study identified 99 patients with active malignant GI bleeding (primary or metastatic) treated with Tc-325. Eleven patients were excluded because of incomplete data...
April 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29124127/effectiveness-of-tc-325-hemospray-for-treatment-of-diffuse-or-refractory-upper-gastrointestinal-bleeding-a-single-center-experience
#5
Oscar Cahyadi, Markus Bauder, Benjamin Meier, Karel Caca, Arthur Schmidt
Background and study aims:  TC-325 (Hemospray, Cook Medical) is a powder agent for endoscopic hemostasis in patients with upper gastrointestinal bleeding (UGIB). Although most publications are based on case-reports and retrospective studies, data on efficacy are promising. Here we report our experience with TC-325 for diffuse or refractory UGIB. Patients and methods:  Data on patients receiving TC-325 for endoscopic hemostasis from November 2013 to February 2017 at our center were analyzed retrospectively...
November 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28565729/combined-endoscopic-and-surgical-treatment-of-severe-gastrointestinal-bleeding-in-a-patient-with-heart-assist-device-under-therapeutic-anticoagulation
#6
Edris Wedi, Mohamed Bounnah, Riccardo Memeo, Carlo Jung
Gastrointestinal (GI) bleeding is a common complication after heart assist device placement. Reasons for bleeding are multifactorial. Endoscopic therapy is the treatment of choice, whereas invasive procedures are avoided in these critically ill patients. We present the case of a 65-year-old male patient experiencing severe GI bleeding after left ventricular assist device (LVAD) and right ventricular assist device (RVAD) placement with therapeutic anticoagulation. Endoscopically, multiple gastric bleeding sources were found but could not be treated effectively due to a large blood clot...
November 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28485544/tc-325-versus-the-conventional-combined-technique-for-endoscopic-treatment-of-peptic-ulcers-with-high-risk-bleeding-stigmata-a-randomized-pilot-study
#7
RANDOMIZED CONTROLLED TRIAL
Boon Eu Andrew Kwek, Tiing Leong Ang, Peng Lan Jeannie Ong, Yi Lyn Jessica Tan, Shih Wen Daphne Ang, Ngai Moh Law, Prem Harichander Thurairajah, Kwong Ming Fock
OBJECTIVE: Preliminary studies on a new topical hemostatic agent, TC-325, have shown its safety and effectiveness in treating active upper gastrointestinal (GI) bleeding. However, to date there have been no randomized trials comparing TC-325 with the conventional combined technique (CCT). Our pilot study aimed to compare the efficacy and safety of TC-325 with those of CCT in treating peptic ulcers with active bleeding or high-risk stigmata. METHODS: This was a comparative randomized study of patients with upper GI bleeding who had Forrest class I, IIA or IIB ulcers...
June 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28252348/an-unusual-haemorrhagic-complication-of-an-anastomotic-leak-and-a-novel-method-of-controlling-the-haemorrhage
#8
S Martin, A Armstrong
Introduction Restorative proctocolectomy (RP) is undertaken for patients with familial adenomatous polyposis (FAP) and ulcerative colitis, but is associated with a risk of anastomotic leak. Case history A 20-year-old male with a family history of FAP had a RP with a double-stapled J-pouch and covering loop ileostomy. At ileostomy reversal 21 months later, he presented with significant anal bleeding. He proceeded to theatre for endoscopy. Pouchoscopy showed a pouch full of blood and a foreign object trapped in a diverticulum...
March 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28065526/hemospray-for-treatment-of-acute-bleeding-due-to-upper-gastrointestinal-tumours
#9
MULTICENTER STUDY
Monica Arena, Enzo Masci, Leonardo Henry Eusebi, Giuseppe Iabichino, Benedetto Mangiavillano, Paolo Viaggi, Elisabetta Morandi, Lorella Fanti, Antonino Granata, Mario Traina, Pier Alberto Testoni, Enrico Opocher, Carmelo Luigiano
BACKGROUND: Hemospray is a new endoscopic haemostatic powder that can be used in the management of upper gastrointestinal bleedings. AIMS: To assess the efficacy and safety of Hemospray as monotherapy for the treatment of acute upper gastrointestinal bleeding due to cancer. METHODS: The endoscopy databases of 3 Italian Endoscopic Units were reviewed retrospectively and 15 patients (8 males; mean age 74 years) were included in this study. RESULTS: Immediate haemostasis was achieved in 93% of cases...
May 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27998629/usefulness-of-hemospray-in-a-patient-with-refractory-lower-gastrointestinal-bleeding-secondary-to-a-caecal-ulcer-caused-by-cytomegalovirus
#10
LETTER
Rubén Diez-Rodríguez, Rocio Silvana Castillo-Trujillo, Martha Lucia González-Bárcenas, Cristina Pisabarros-Blanco, Ana Barrientos-Castañeda
No abstract text is available yet for this article.
January 2018: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27995200/hemospray-use-in-upper-gastrointestinal-bleeding-from-tumor-is-it-the-answer
#11
Sofia Xavier, Joana Magalhães, Bruno Rosa, José Cotter
No abstract text is available yet for this article.
December 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27995199/reply-to-xavier-s-and-colleague-hemospray-use-in-upper-gastrointestinal-bleeding-from-tumor-is-it-the-answer
#12
Rapat Pittayanon, Piyapan Prueksapanich, Rungsun Rerknimitr
No abstract text is available yet for this article.
December 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27888865/advances-in-gastrointestinal-bleeding
#13
Ángel Lanas
The main innovations of the latest meeting of the Gastroenterological Association (2016) concerning upper gastrointestinal bleeding from the clinician's perspective can be summarised as follows: a) The Glasgow-Blatchford scale has the best accuracy in predicting the need for surgical intervention and hospital mortality; b) Prognostic scales for non-variceal upper gastrointestinal bleeding are also useful for lower gastrointestinal bleeding; c) Preliminary data suggest that treatment with hemospray does not seem to be superior to current standard treatment in controlling active peptic ulcer bleeding; d) Either famotidine or a proton pump inhibitor may be effective in preventing haemorrhagic recurrence in patients taking aspirin, but this finding needs to be confirmed in further studies; e) There was confirmation of the need to re-introduce antiplatelet therapy as early as possible in patients with antiplatelet-associated gastrointestinal bleeding in order to prevent cardiovascular mortality; f) Routine clinical practice suggests that gastrointestinal or cardiovascular complications with celecoxib or traditional NSAIDs are very low; g) Dabigatran is associated with an increased incidence of gastrointestinal bleeding compared with apixaban or warfarin...
September 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27760437/a-novel-hemostatic-powder-for-upper-gastrointestinal-bleeding-a-multicenter-study-the-graphe-registry
#14
MULTICENTER STUDY
Sami Haddara, Jeremie Jacques, Stéphane Lecleire, Julien Branche, Sarah Leblanc, Yann Le Baleur, Jocelyn Privat, Laurent Heyries, Philippe Bichard, Philippe Granval, Ulriikka Chaput, Stephane Koch, Jonathan Levy, Bruno Godart, Antoine Charachon, Jean-François Bourgaux, Elodie Metivier-Cesbron, Edouard Chabrun, Vincent Quentin, Bastien Perrot, Geoffroy Vanbiervliet, Emmanuel Coron
Background and study aims: The hemostatic powder TC-325 (Hemospray; Cook Medical, Winston-Salem, North Carolina, USA) has shown promising results in the treatment of upper gastrointestinal bleeding (UGIB) in expert centers in pilot studies. The aim of this study was to evaluate the feasibility and efficacy of TC-325 in a large prospective registry of use in routine practice. Patients and methods: The data of all patients treated with TC-325 were prospectively collected through a national registry. Outcomes were the immediate feasibility and efficacy of TC-325 application, as well as the rates of rebleeding at Day 8 and Day 30...
December 2016: Endoscopy
https://www.readbyqxmd.com/read/27749635/using-hemospray-improves-the-cost-effectiveness-ratio-in-the-management-of-upper-gastrointestinal-nonvariceal-bleeding
#15
Alan N Barkun, Viviane Adam, Yidan Lu, Yen-I Chen, Myriam Martel
GOALS: We compared the cost-effectiveness of traditional recommended endoscopic hemostatic therapies and Hemospray alone or in combination when treating nonvariceal upper gastrointestinal bleeding (NVUGIB). BACKGROUND: Hemospray (TC-325) is a novel endoscopic hemostatic powder, achieving hemostasis through adherence to actively bleeding biological surfaces. STUDY: A decision tree of patients with NVUGIB assessed 4 possible treatment strategies: traditional therapy alone (T), Hemospray alone (H), traditional therapy completed by Hemospray if needed (T+H), or Hemospray completed by traditional therapy if needed (H+T)...
January 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27744662/novel-therapeutic-strategies-in-the-management-of-non-variceal-upper-gastrointestinal-bleeding
#16
REVIEW
Ari Garber, Sunguk Jang
Non-variceal upper gastrointestinal bleeding, the most common etiology of which is peptic ulcer disease, remains a persistent challenge despite a reduction in both its incidence and mortality. Both pharmacologic and endoscopic techniques have been developed to achieve hemostasis, with varying degrees of success. Among the pharmacologic therapies, proton pump inhibitors remain the mainstay of treatment, as they reduce the risk of rebleeding and requirement for recurrent endoscopic evaluation. Tranexamic acid, a derivative of the amino acid lysine, is an antifibrinolytic agent whose role requires further investigation before application...
September 2016: Clinical Endoscopy
https://www.readbyqxmd.com/read/27652296/the-efficacy-of-hemospray-in-patients-with-upper-gastrointestinal-bleeding-from-tumor
#17
Rapat Pittayanon, Piyapan Prueksapanich, Rungsun Rerknimitr
BACKGROUND AND STUDY AIMS: Currently, conventional endoscopic treatments provide an unsatisfactory hemostatic outcome in upper gastrointestinal bleeding from tumor. Hemospray has been shown to be useful in many active gastrointestinal bleeding conditions. This study aimed to compare the efficacy of Hemospray and conventional endoscopic hemostasis. PATIENTS AND METHODS: Fourteen patients with active upper gastrointestinal bleeding from tumor were recruited. Hemospray was applied at the bleeding site until hemostasis was achieved...
September 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27367448/successful-use-of-hemospray-as-a-bridge-to-surgery-in-life-threatening-bleeding-from-a-gastrointestinal-stromal-tumor-of-the-stomach
#18
Giovanna Venezia, Giuliano Asnaghi, Aldo Manca, Luigi Ghezzo
No abstract text is available yet for this article.
2016: Endoscopy
https://www.readbyqxmd.com/read/27170285/hemospray-treatment-for-bleeding-intestinal-anastomoses-in-the-early-postoperative-period-a-novel-non-operative-approach
#19
C Gubler, J M Metzler, M Turina
No abstract text is available yet for this article.
July 2016: Techniques in Coloproctology
https://www.readbyqxmd.com/read/27108061/the-use-of-hemostatic-spray-as-an-adjunct-to-conventional-hemostatic-measures-in-high-risk-nonvariceal-upper-gi-bleeding-with-video
#20
Rohit Sinha, Khalida A Lockman, Nicholas I Church, John N Plevris, Peter C Hayes
BACKGROUND: Endoscopic management of nonvariceal upper GI bleed (NVUGIB) can be challenging. Hemospray is a novel endoscopic hemostatic agent for NVUGIB. Its efficacy in attaining hemostasis in NVUGIB is promising, particularly with respect to technically difficult lesions. However, most of the currently available data are focused on its application as monotherapy. The aim of this study was to evaluate its efficacy as a second agent to adrenaline, or as an addition to the combination of adrenaline with either clips or a thermal device in NVUGIB...
December 2016: Gastrointestinal Endoscopy
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