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Alan N Barkun, Viviane Adam, Yidan Lu, Yen-I Chen, Myriam Martel
GOALS: We compared the cost-effectiveness of traditional recommended endoscopic hemostatic therapies and Hemospray alone or in combination when treating nonvariceal upper gastrointestinal bleeding (NVUGIB). BACKGROUND: Hemospray (TC-325) is a novel endoscopic hemostatic powder, achieving hemostasis through adherence to actively bleeding biological surfaces. STUDY: A decision tree of patients with NVUGIB assessed 4 possible treatment strategies: traditional therapy alone (T), Hemospray alone (H), traditional therapy completed by Hemospray if needed (T+H), or Hemospray completed by traditional therapy if needed (H+T)...
October 4, 2016: Journal of Clinical Gastroenterology
Ari Garber, Sunguk Jang
Non-variceal upper gastrointestinal bleeding, the most common etiology of which is peptic ulcer disease, remains a persistent challenge despite a reduction in both its incidence and mortality. Both pharmacologic and endoscopic techniques have been developed to achieve hemostasis, with varying degrees of success. Among the pharmacologic therapies, proton pump inhibitors remain the mainstay of treatment, as they reduce the risk of rebleeding and requirement for recurrent endoscopic evaluation. Tranexamic acid, a derivative of the amino acid lysine, is an antifibrinolytic agent whose role requires further investigation before application...
September 2016: Clinical Endoscopy
Rapat Pittayanon, Piyapan Prueksapanich, Rungsun Rerknimitr
BACKGROUND AND STUDY AIMS: Currently, conventional endoscopic treatments provide an unsatisfactory hemostatic outcome in upper gastrointestinal bleeding from tumor. Hemospray has been shown to be useful in many active gastrointestinal bleeding conditions. This study aimed to compare the efficacy of Hemospray and conventional endoscopic hemostasis. PATIENTS AND METHODS: Fourteen patients with active upper gastrointestinal bleeding from tumor were recruited. Hemospray was applied at the bleeding site until hemostasis was achieved...
September 2016: Endoscopy International Open
Giovanna Venezia, Giuliano Asnaghi, Aldo Manca, Luigi Ghezzo
No abstract text is available yet for this article.
2016: Endoscopy
C Gubler, J M Metzler, M Turina
No abstract text is available yet for this article.
July 2016: Techniques in Coloproctology
Rohit Sinha, Khalida A Lockman, Nicholas I Church, John N Plevris, Peter C Hayes
BACKGROUND: Endoscopic management of nonvariceal upper GI bleed (NVUGIB) can be challenging. Hemospray is a novel endoscopic hemostatic agent for NVUGIB. Its efficacy in attaining hemostasis in NVUGIB is promising, particularly with respect to technically difficult lesions. However, most of the currently available data are focused on its application as monotherapy. The aim of this study was to evaluate its efficacy as a second agent to adrenaline, or as an addition to the combination of adrenaline with either clips or a thermal device in NVUGIB...
April 21, 2016: Gastrointestinal Endoscopy
Stefan Karl Goelder, Juliane Brueckner, Helmut Messmann
New endoscopic techniques for hemostasis in nonvariceal bleeding were introduced and known methods further improved. Hemospray and Endoclot are two new compounds for topical treatment of bleeding. Initial studies in this area have shown a good hemostatic effect, especially in active large scale oozing bleeding, e.g., tumor bleedings. For further evaluation larger prospective studies comparing the substanced with other methods of endoscopic hemostasis are needed. For localized active arterial bleeding primary injection therapy in the area of ​​bleeding as well as in the four adjacent quadrants offers a good method to reduce bleeding activity...
February 25, 2016: World Journal of Gastrointestinal Endoscopy
Hrvoje Ivekovic, Branko Bilic, Pave Markos, Nadan Rustemovic, Rajko Ostojic, Klaus Mönkemüller
No abstract text is available yet for this article.
2015: Endoscopy
Samuel Han, Nabeel Chaudhary, Wahid Wassef
PURPOSE OF REVIEW: Portal hypertensive gastropathy (PHG) and gastric antral vascular ectasia (GAVE) are two types of upper gastrointestinal bleeding that may present similarly, but are managed very differently. This article reviews the pathogenesis and guidelines in management of both of these conditions with emphasis on recent advances in the field. RECENT FINDINGS: Off-label use of Hemospray has been shown in several case series to be useful in managing acute bleeding from PHG...
November 2015: Current Opinion in Gastroenterology
Mostafa Ibrahim, Ahmed El-Mikkawy, Haitham Abdalla, Ibrahim Mostafa, Jacques Devière
BACKGROUND AND OBJECTIVES: This study aimed to test the safety and efficacy of Hemospray® for emergency control of acute variceal bleeding (AVB) due to portal hypertension in cirrhotic patients. PATIENTS AND METHODS: This single-arm, prospective trial, conducted at two hospitals in Belgium and Egypt, included patients admitted to the emergency room with hematemesis and/or melena and known or suspected liver cirrhosis. All patients received urgent hemodynamic stabilization, octreotide (50 mcg bolus then 25 mcg/hour for 24 hours) and intravenous ceftriaxone (1 g/hour)...
June 2015: United European Gastroenterology Journal
Antonino Granata, Dario Ligresti, Gabriele Curcio, Luca Barresi, Ilaria Tarantino, Rosalba Orlando, Mario Traina
No abstract text is available yet for this article.
2015: Endoscopy
Kinesh Changela, Haris Papafragkakis, Emmanuel Ofori, Mel A Ona, Mahesh Krishnaiah, Sushil Duddempudi, Sury Anand
Gastrointestinal bleeding is a leading cause of morbidity and mortality in the United States. The management of gastrointestinal bleeding is often challenging, depending on its location and severity. To date, widely accepted hemostatic treatment options include injection of epinephrine and tissue adhesives such as cyanoacrylate, ablative therapy with contact modalities such as thermal coagulation with heater probe and bipolar hemostatic forceps, noncontact modalities such as photodynamic therapy and argon plasma coagulation, and mechanical hemostasis with band ligation, endoscopic hemoclips, and over-the-scope clips...
May 2015: Therapeutic Advances in Gastroenterology
Georg Braun, Helmut Messmann
The number of patients taking new oral anticoagulants is rising, so is the number of serious bleeding events. In severe bleeding, the decision to start a procoagulant therapy is difficult to take. With Idarucizumab and Andexanet Alfa, specific antidotes have been developed against both, direct thrombin inhibitors as well as direct Factor Xa inhibitors. In the endoscopic treatment of severe gastrointestinal bleeding, alternative treatment options are available with Hemospray™, Endoclot™ and new hemostasis clips...
June 2015: Deutsche Medizinische Wochenschrift
B Beye, M Barret, A Alatawi, F Beuvon, C Nicco, C A Pratico, C Chereau, S Chaussade, F Batteux, F Prat
The development of techniques for endoscopic resection has provided new strategies for radical conservative treatment of superficial esophageal neoplasms, even those that are circumferential, such as Barrett's neoplasia. However, it is necessary to prevent the formation of scar tissue that can be responsible for esophageal strictures following circumferential resection. Preliminary data have suggested the possible efficacy of a hemostatic powder in the promotion of wound healing. The study aims to assess the effectiveness of Hemospray (Cook Medical) in a swine model of post-endoscopic esophageal stricture...
August 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Antonino Granata, Gabriele Curcio, Luca Barresi, Dario Ligresti, Ilaria Tarantino, Rosalba Orlando, Mario Traina
No abstract text is available yet for this article.
March 2016: International Journal of Colorectal Disease
Milán Szalai, Tamás Kullmann, Henryka Durcsán, Henriett Regőczi, Gyöngyi Kiss, István Rácz
INTRODUCTION: Early endoscopic diagnosis and endoscopic therapy are very important in cases of acute gastrointestinal bleeding. Hemospray is an inorganic powder with hemostatic properties recently proposed for the treatment of acute gastrointestinal bleeding. AIM: The aim of the authors was to report the first Hungarian experience obtained with Hemospray in patients with acute gastrointestinal bleeding. METHOD: During a 14-month period 10 acute upper gastrointestinal bleeder patients were treated endoscopically with Hemospray in 11 settings...
March 29, 2015: Orvosi Hetilap
I Lisanne Holster, Heleen M M van Beusekom, Ernst J Kuipers, Frank W G Leebeek, Moniek P M de Maat, Eric T T L Tjwa
BACKGROUND AND STUDY AIMS: Hemospray (Cook Medical Inc., Winston-Salem, North Carolina, USA) is a novel, hemostatic, powder spray that has been developed for gastrointestinal use. The powder is thought to achieve hemostasis by concentrating clotting factors and forming a mechanical plug on the injured blood vessel. However, no detailed studies on the hemostatic mode of action have been performed. The aim of this study was to examine the effects of Hemospray on coagulation and clot formation both in vitro and in vivo...
July 2015: Endoscopy
Christian Dietrich, Rico Hochdörffer, Erik S Fuchs, Stephan Vetter, Ralf Jakobs, Matthias Bechtler
No abstract text is available yet for this article.
2014: Endoscopy
Liz Toapanta-Yanchapaxi, Norberto Chavez-Tapia, Félix Téllez-Ávila
Gastrointestinal bleeding can be a life-treating event that is managed with standard endoscopic therapy in the majority of cases. However, up to 5%-10% of patients may have persistent bleeding that does not respond to conventional measures. Several endoscopic treatment techniques have been proposed as strategies to control such cases, such as epinephrine injection, hemoclips or argon plasma coagulation, but there are certain clinical scenarios where it is difficult to achieve hemostasis even though adequate use of the available resources is made...
September 16, 2014: World Journal of Gastrointestinal Endoscopy
Enzo Masci, Monica Arena, Elisabetta Morandi, Paolo Viaggi, Benedetto Mangiavillano
INTRODUCTION AND OBJECTIVES: Acute gastrointestinal (GI) bleeding can lead from mild to immediately life-threatening clinical conditions. Upper GI bleeding (UGIB) is associated with a mortality of 6-10%. Spurting and oozing bleeding are associated with major risk of failure. Hemospray™ (TC-325), a new hemostatic powder, may be useful in these cases. Aim of this study is to review the efficacy of traditional endoscopic treatment in Forrest 1a-1b ulcers and to investigate the usefulness of Hemospray in these patients...
November 2014: Scandinavian Journal of Gastroenterology
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