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https://www.readbyqxmd.com/read/28162769/cord-blood-biomarkers-of-placental-maternal-vascular-underperfusion-predict-bronchopulmonary-dysplasia-associated-pulmonary-hypertension
#1
Karen K Mestan, Nina Gotteiner, Nicolas Porta, William Grobman, Emily J Su, Linda M Ernst
OBJECTIVE: To assess whether cord blood biomarkers associated with placental maternal vascular underperfusion (MVU) are predictive of bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH). STUDY DESIGN: Premature infants enrolled in a longitudinal cohort study were randomly sampled from 4 gestational age strata (n = 190, range 23-36 weeks). Fifteen factors from a human angiogenesis panel were measured in cord blood using multiplex immunoassay...
February 2, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28153660/attempted-operative-vaginal-delivery-versus-repeat-cesarean-in-the-second-stage-among-women-undergoing-a-trial-of-labor-after-cesarean-delivery
#2
Moeun Son, Archana Roy, William A Grobman
BACKGROUND: It is not well characterized whether attempting operative vaginal delivery (OVD) is a safe and effective alternative among women undergoing a trial of labor after cesarean delivery (TOLAC) who are unable to complete second-stage labor with a spontaneous vaginal delivery. OBJECTIVE: To compare maternal and neonatal outcomes associated with attempted OVD to those associated with second-stage repeat cesarean delivery (RCD) without OVD attempt among women undergoing a TOLAC...
January 28, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28056690/2016-guidelines-of-the-american-thyroid-association-for-the-diagnosis-and-management-of-thyroid-disease-during-pregnancy-and-the-postpartum
#3
Erik K Alexander, Elizabeth N Pearce, Gregory A Brent, Rosalind S Brown, Herbert Chen, Chrysoula Dosiou, William Grobman, Peter Laurberg, John H Lazarus, Susan J Mandel, Robin Peeters, Scott Sullivan
BACKGROUND: Thyroid disease in pregnancy is a common clinical problem. Since the American Thyroid Association's (ATA's) guidelines for the management of these disorders were first published in 2011, significant clinical and scientific advances have occurred in the field. The aim of these guidelines is to inform clinicians, patients, researchers, and health policy makers on published evidence relating to the diagnosis and management of thyroid disease in women during pregnancy, preconception and the postpartum period...
January 6, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27960618/histologic-changes-of-mesenchymal-stem-cell-repair-of-tympanic-membrane-perforation
#4
Stefania Goncalves, Esperanza Bas, Michael Langston, Ariel Grobman, Bradley J Goldstein, Simon Angeli
CONCLUSION: Mesenchymal stem-cells are good candidates for cell-therapy of chronic tympanic membranes perforations. OBJECTIVES: To determine the effects of cell-based therapy in tympanic membrane perforations. METHODS: Young C57BL/6 mice were anesthetized with intraperitoneal administration of ketamine and xylazine and randomly divided into three groups (n = 4 ears/group) that underwent bilateral sub-total pars tensa perforations of equal sizes using a sterile 27-gauge needle under a surgical microscope...
December 14, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27939467/a-protocol-for-developing-disseminating-and-implementing-a-core-outcome-set-for-pre-eclampsia
#5
James M N Duffy, Janneke van 't Hooft, Chris Gale, Mark Brown, William Grobman, Ray Fitzpatrick, S Ananth Karumanchi, Nuala Lucas, Laura Magee, Ben Mol, Michael Stark, Shakila Thangaratinam, Mathew Wilson, Peter von Dadelszen, Paula Williamson, Khalid S Khan, Sue Ziebland, Richard J McManus
BACKGROUND: Pre-eclampsia is a serious complication of pregnancy and contributes to maternal and offspring mortality and morbidity. Randomised controlled trials evaluating therapeutic interventions for pre-eclampsia have reported many different outcomes and outcome measures. Such variation contributes to an inability to compare, contrast, and combine individual studies, limiting the usefulness of research to inform clinical practice. The development and use of a core outcome set would help to address these issues ensuring outcomes important to all stakeholders, including patients, will be collected and reported in a standardised fashion...
October 2016: Pregnancy Hypertension
https://www.readbyqxmd.com/read/27926645/association-between-sleep-disordered-breathing-and-hypertensive-disorders-of-pregnancy-and-gestational-diabetes-mellitus
#6
Francesca L Facco, Corette B Parker, Uma M Reddy, Robert M Silver, Matthew A Koch, Judette M Louis, Robert C Basner, Judith H Chung, Chia-Ling Nhan-Chang, Grace W Pien, Susan Redline, William A Grobman, Deborah A Wing, Hyagriv N Simhan, David M Haas, Brian M Mercer, Samuel Parry, Daniel Mobley, Shannon Hunter, George R Saade, Frank P Schubert, Phyllis C Zee
OBJECTIVE: To estimate whether sleep-disordered breathing during pregnancy is a risk factor for the development of hypertensive disorders of pregnancy and gestational diabetes mellitus (GDM). METHODS: In this prospective cohort study, nulliparous women underwent in-home sleep-disordered breathing assessments in early (6-15 weeks of gestation) and midpregnancy (22-31 weeks of gestation). Participants and health care providers were blinded to the sleep test results...
January 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27830971/psychometric-properties-of-stress-and-anxiety-measures-among-nulliparous-women
#7
Carla M Bann, Corette B Parker, William A Grobman, Marian Willinger, Hyagriv N Simhan, Deborah A Wing, David M Haas, Robert M Silver, Samuel Parry, George R Saade, Ronald J Wapner, Michal A Elovitz, Emily S Miller, Uma M Reddy
OBJECTIVE: To examine the psychometric properties of three measures, the perceived stress scale (PSS), pregnancy experience scale (PES), and state trait anxiety inventory (STAI), for assessing stress and anxiety during pregnancy among a large sample of nulliparous women. METHODS: The sample included 10,002 pregnant women participating in the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (nMoM2b). Internal consistency reliability was assessed with Cronbach's alpha and factorial validity with confirmatory factor analyses...
November 10, 2016: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27824768/relationship-between-excessive-gestational-weight-gain-and-neonatal-adiposity-in-women-with-mild-gestational-diabetes-mellitus
#8
Sean C Blackwell, Mark B Landon, Lisa Mele, Uma M Reddy, Brian M Casey, Ronald J Wapner, Michael W Varner, Dwight J Rouse, John M Thorp, Anthony Sciscione, Patrick Catalano, George Saade, Steve N Caritis, Yoram Sorokin, William A Grobman
OBJECTIVE: To evaluate the relationships among excessive gestational weight gain, neonatal adiposity, and adverse obstetric outcomes in women with mild gestational diabetes mellitus. METHODS: This is a secondary analysis of a multicenter randomized clinical trial of women with mild gestational diabetes mellitus. Based on self-reported prepregnancy body weight, gestational weight gain was categorized as excessive if it was greater than 2009 Institute of Medicine guidelines...
December 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27752158/-application-of-seven-prediction-models-of-vaginal-birth-after-cesarean-in-a-chinese-hospital
#9
T Mu, Y Wang, G L Liu, J L Wang
OBJECTIVE: To evaluate the seven existing vaginal birth after cesarean (VBAC) screening tools and to identify additional factors that may predict VBAC or failed trial of labor in China. METHODS: In the study, 53 patients with 1 previous cesarean delivery who then delivered between January 1, 2007 and Novenber 31, 2014 were recruited. The average age of the patients was (32.1±3.5) years,the average gestational age was (38.0±2.3) weeks. There was no significant difference of the successful group and the failed group in the maternal/neonatal mortality and morbidity, also in the incidence of the postpartum hemorrhage and the postpartum infection...
October 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27615067/patterns-of-peripheral-cytokine-expression-during-pregnancy-in-two-cohorts-and-associations-with-inflammatory-markers-in-cord-blood
#10
Kharah MacKenzie Ross, Gregory Miller, Jennifer Culhane, William Grobman, Hyagriv N Simhan, Pathik D Wadhwa, Douglas Williamson, Thomas McDade, Claudia Buss, Sonja Entringer, Emma Adam, Sameen Qadir, Lauren Keenan-Devlin, Adam K K Leigh, Ann Borders
PROBLEM: Maternal inflammation undergoes adaptations during pregnancy, and excessive inflammation has been associated with adverse outcomes. One mechanism may be maternal inflammation transmission to the fetal compartment. Links between maternal pregnancy inflammation and fetal inflammation are poorly characterized. METHOD: Principal components analysis was used to extract underlying inflammation components across cytokines (IFN-γ, IL-10, IL-13, IL-6, IL-8, TNF-α) in two pregnancy cohorts (SPAH N=87, MOMS N=539) assessed during the second and third trimesters...
November 2016: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/27607865/perinatal-outcomes-in-cephalic-compared-with-noncephalic-singleton-presentation-in-the-setting-of-preterm-premature-rupture-of-membranes-before-32-weeks-of-gestation
#11
Lynn M Yee, William A Grobman
OBJECTIVE: To investigate the relationship between fetal presentation at the time of admission for preterm premature rupture of membranes (PROM) and perinatal outcomes, including gestational latency, among women in a large and well-characterized population with preterm PROM at less than 32 weeks of gestation. METHODS: This was a secondary analysis of data from women randomized to receive magnesium sulfate compared with placebo in the previously reported Maternal-Fetal Medicine Units Network Beneficial Effects of Antenatal Magnesium Sulfate (1997-2004) trial...
October 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27589899/obstetrician-call-schedule-and-obstetric-outcomes-among-women-eligible-for-a-trial-of-labor-after-cesarean
#12
Lynn M Yee, Lilly Y Liu, William A Grobman
BACKGROUND: Reducing cesarean deliveries is a major public health goal. The low rate of vaginal birth after cesarean has been attributed largely to a decrease in the likelihood of choosing a trial of labor after cesarean, despite evidence suggesting a majority of women with 1 prior low transverse cesarean are trial of labor after cesarean candidates. Although a number of reasons for this decrease have been explored, it remains unclear how systems issues such as physician call schedules influence delivery approach and mode in this context...
January 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27500932/racial-ethnic-disparities-in-measures-of-self-reported-psychosocial-states-and-traits-during-pregnancy
#13
William A Grobman, Corette Parker, Pathik D Wadhwa, Marian Willinger, Hyagriv Simhan, Bob Silver, Ron J Wapner, Samuel Parry, Brian Mercer, David Haas, Alan M Peaceman, Shannon Hunter, Deborah Wing, Steve Caritis, Sean Esplin, Matt Hoffman, Jack Ludmir, Jay Iams, Emily Long, George Saade, Uma M Reddy
Background The aim of this study was to determine whether racial/ethnic differences in psychosocial measures, independent of economic status, exist among a large population of pregnant nulliparas. Methods Between October 2010 and September 2013, nulliparous women at eight U.S. medical centers were followed longitudinally during pregnancy and completed validated instruments to quantify several psychosocial domains: Cohen Perceived Stress Scale, trait subscale of the Spielberger Anxiety Inventory, Connor-Davidson Resilience Scale, Multidimensional Scale of Perceived Social Support, Krieger Racism Scale, Edinburgh Postnatal Depression Scale, and the Pregnancy Experience Scale...
December 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27500344/association-of-recorded-estimated-fetal-weight-and-cesarean-delivery-in-attempted-vaginal-delivery-at-term
#14
Rosemary J Froehlich, Grecio Sandoval, Jennifer L Bailit, William A Grobman, Uma M Reddy, Ronald J Wapner, Michael W Varner, John M Thorp, Mona Prasad, Alan T N Tita, George Saade, Yoram Sorokin, Sean C Blackwell, Jorge E Tolosa
OBJECTIVE: To evaluate the association between documentation of estimated fetal weight, and its value, with cesarean delivery. METHODS: This was a secondary analysis of a multicenter observational cohort of 115,502 deliveries from 2008 to 2011. Data were abstracted by trained and certified study personnel. We included women at 37 weeks of gestation or greater attempting vaginal delivery with live, nonanomalous, singleton, vertex fetuses and no history of cesarean delivery...
September 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27500341/association-of-early-amniotomy-after-foley-balloon-catheter-ripening-and-duration-of-nulliparous-labor-induction
#15
Ashley N Battarbee, Anna Palatnik, Danielle A Peress, William A Grobman
OBJECTIVE: To evaluate the association between early amniotomy after ripening with a Foley balloon catheter and duration of labor induction. METHODS: In this retrospective matched cohort study, 546 nulliparous women with a singleton viable gestation undergoing cervical ripening with a Foley balloon catheter were compared based on timing of amniotomy after catheter removal: early (defined as artificial rupture of membranes less than 1 hour after Foley removal) compared with no artificial rupture of membranes in the first hour...
September 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27454716/in-reply
#16
William A Grobman
No abstract text is available yet for this article.
August 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27425431/prediction-with-conviction-a-stepwise-guide-toward-improving-prediction-and-clinical-care
#17
E S Miller, W A Grobman
No abstract text is available yet for this article.
July 17, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27418448/society-for-maternal-fetal-medicine-smfm-special-report-current-approaches-to-measuring-quality-of-care-in-obstetrics
#18
Jennifer L Bailit, Kimberly D Gregory, Sindhu Srinivas, Thomas Westover, William A Grobman, George R Saade
Heath care measurement and evaluation is an integral piece of the health care system. The creation and assessment of care performance metrics are important and relevant for the obstetric community including both clinicians and patients. Careful deliberation is required to create a measurement system that results in optimal care for women and families. This article reviews the current approaches to measuring quality in obstetrics.
September 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27416693/a-deep-sea-diver-with-cement-pulmonary-embolism
#19
Roya Memarpour, Basheer Tashtoush, Faria Nasim, Daniel Grobman, Bharat K Upadhyay, Franck Rahaghi
Cement pulmonary embolism is a rare complication of cement kyphoplasty. These emboli are often asymptomatic and commonly detected many years after the procedure as incidental findings on radiographic imaging. We herein report a case of a 32-year-old professional diver who was diagnosed with asymptomatic cement pulmonary emboli during his annual diving physical exam. After two years of follow-up the patient remained asymptomatic and resumed his career in professional diving, which included deep sea diving activities with no evidence of respiratory limitations or long-term complications...
May 2016: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/27392704/prenatal-stress-and-the-cortisol-awakening-response-in-african-american-and-caucasian-women-in-the-third-trimester-of-pregnancy
#20
Clarissa D Simon, Emma K Adam, Jane L Holl, Kaitlin A Wolfe, William A Grobman, Ann E B Borders
Objectives Prior studies have shown significant racial disparities in psychosocial stressors for pregnant women. One physiological mechanism by which prenatal stress is expressed is via the stress-sensitive hormone cortisol, which itself differs by race. In this study, we examine differences in cortisol awakening response (CAR) for African-American and Caucasian pregnant women during late pregnancy, particularly whether racial disparities are evident after accounting for measures of psychosocial stress. Methods During their third trimester of pregnancy (32-40 weeks of gestation), we asked women to self-collect salivary samples at home over 2 days...
October 2016: Maternal and Child Health Journal
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