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https://www.readbyqxmd.com/read/28931404/a-cluster-randomized-trial-to-reduce-major-perinatal-morbidity-among-women-with-one-prior-cesarean-delivery-in-qu%C3%A3-bec-prisma-trial-study-protocol-for-a-randomized-controlled-trial
#1
N Chaillet, E Bujold, B Masse, W A Grobman, P Rozenberg, J C Pasquier, A Shorten, M Johri, F Beaudoin, H Abenhaim, S Demers, W Fraser, M Dugas, S Blouin, E Dubé, R Gauthier
BACKGROUND: Rates of cesarean delivery are continuously increasing in industrialized countries, with repeated cesarean accounting for about a third of all cesareans. Women who have undergone a first cesarean are facing a difficult choice for their next pregnancy, i.e.: (1) to plan for a second cesarean delivery, associated with higher risk of maternal complications than vaginal delivery; or (b) to have a trial of labor (TOL) with the aim to achieve a vaginal birth after cesarean (VBAC) and to accept a significant, but rare, risk of uterine rupture and its related maternal and neonatal complications...
September 20, 2017: Trials
https://www.readbyqxmd.com/read/28925085/-18-f-fdg-pet-ct-as-adjunctive-diagnostic-modalities-in-canine-fever-of-unknown-origin
#2
Megan Grobman, Leah Cohn, Stephanie Knapp, Jeffrey N Bryan, Carol Reinero
Fever of unknown origin (FUO) is a persistent or recurrent fever for which the underlying source has not been identified despite diagnostic investigation. In people, (18) F-fluoro-2-deoxyglucose positron emission tomography ((18) F-FDG-PET) alone or in combination with computed tomography (CT) is often beneficial in detecting the source of fever when other diagnostics have failed. Veterinary reports describing use of these modalities in animals with fever of unknown origin are currently lacking. Aims of this retrospective case series were to describe (18) F-FDG-PET or (18) F-FDG-PET/CT findings in a group of dogs with fever of unknown origin...
September 18, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28915515/the-association-of-decision-to-incision-time-for-cesarean-delivery-with-maternal-and-neonatal-outcomes
#3
William A Grobman, Jennifer Bailit, Grecio Sandoval, Uma M Reddy, Ronald J Wapner, Michael W Varner, John M Thorp, Steve N Caritis, Mona Prasad, Alan T N Tita, George R Saade, Yoram Sorokin, Dwight J Rouse, Sean C Blackwell, Jorge E Tolosa
No abstract text is available yet for this article.
September 15, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28894829/the-effect-of-n-acetyl-cysteine-on-recovery-of-the-facial-nerve-after-crush-injury
#4
Andrew Rivera, Mallory Raymond, Ariel Grobman, Marianne Abouyared, Simon I Angeli
OBJECTIVE: Facial nerve dysfunction can vary in severity and recovery is dependent on the character of the injury. N-acetyl-cysteine prevents oxidative stress and cellular damage, and its use in the setting of nerve dysfunction from crush injury has not yet been established. In this study, rats with facial nerve crush injury will be treated with n-acetyl-cysteine or control and functional recovery and electrophysiologic outcome will be compared. STUDY DESIGN: Prospective, randomized animal study...
June 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28863031/association-between-intrapartum-magnesium-administration-and-the-incidence-of-maternal-fever-a-retrospective-cross-sectional-study
#5
Elizabeth M S Lange, Scott Segal, Carlo Pancaro, Cynthia A Wong, William A Grobman, Gregory B Russell, Paloma Toledo
BACKGROUND: Intrapartum maternal fever is associated with several adverse neonatal outcomes. Intrapartum fever can be infectious or inflammatory in etiology. Increases in interleukin 6 and other inflammatory markers are associated with maternal fever. Magnesium has been shown to attenuate interleukin 6-mediated fever in animal models. We hypothesized that parturients exposed to intrapartum magnesium would have a lower incidence of fever than nonexposed parturients. METHODS: In this study, electronic medical record data from all deliveries at Northwestern Memorial Hospital (Chicago, Illinois) between 2007 and 2014 were evaluated...
September 1, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28804921/serum-thymidine-kinase-1-canine-c-reactive-protein-haptoglobin-and-vitamin-d-concentrations-in-dogs-with-immune-mediated-hemolytic-anemia-thrombocytopenia-and-polyarthropathy
#6
M Grobman, H Outi, H Rindt, C Reinero
BACKGROUND: Relapses of immune-mediated hemolytic anemia (IMHA), thrombocytopenia (ITP), or polyarthropathy (IMPA) occur despite normal hematologic and cytologic parameters. Thymidine kinase 1 (TK1), canine C-reactive protein (c-CRP), haptoglobin (HPT), and 25-Hydroxyvitamin-D (25(OH)D) might be adjunct to current monitoring strategies. HYPOTHESIS/OBJECTIVES: Compare serum concentrations of TK1, c-CRP, HPT, and 25(OH)D in dogs with well- and poorly controlled primary IMHA, ITP, or IMPA...
September 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28796680/association-between-type-of-screening-for-gestational-diabetes-mellitus-and-cesarean-delivery
#7
Anna Palatnik, Kate Swanson, Tessa Churchill, Ania Bilski, William A Grobman, Emily S Miller
OBJECTIVE: To compare maternal and neonatal outcomes using two different testing strategies for gestational diabetes mellitus (GDM) diagnosis: the International Association of the Diabetes and Pregnancy Study Groups (IADPSG) and Carpenter-Coustan approaches. Specifically, we wanted to compare the rates of cesarean delivery between the two epochs. METHODS: This was a retrospective cohort study of women with a singleton pregnancy delivering at 37 0/7 weeks of gestation or greater, between 2010 and 2015, in a single tertiary care center...
September 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28796674/neonatal-morbidity-of-small-and-large-for-gestational-age-neonates-born-at-term-in-uncomplicated-pregnancies
#8
Suneet P Chauhan, Madeline Murguia Rice, William A Grobman, Jennifer Bailit, Uma M Reddy, Ronald J Wapner, Michael W Varner, John M Thorp, Kenneth J Leveno, Steve N Caritis, Mona Prasad, Alan T N Tita, George Saade, Yoram Sorokin, Dwight J Rouse, Jorge E Tolosa
OBJECTIVE: To compare morbidity among small-for-gestational-age (SGA; birth weight less than the 10th percentile for gestational age), appropriate-for-gestational-age (AGA; birth weight 10th to 90th percentile; reference group), and large-for-gestational-age (LGA; birth weight greater than the 90th percentile) neonates in apparently uncomplicated pregnancies at term (37 weeks of gestation or greater). METHODS: This secondary analysis, derived from an observational obstetric cohort of 115,502 deliveries, included women with apparently uncomplicated pregnancies of nonanomalous singletons who had confirmatory ultrasound dating no later than the second trimester and who delivered between 37 0/7 and 42 6/7 weeks of gestation...
September 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28735702/quality-measures-in-high-risk-pregnancies-executive-summary-of-a-cooperative-workshop-of-the-society-for-maternal-fetal-medicine-national-institute-of-child-health-and-human-development-and-the-american-college-of-obstetricians-and-gynecologists
#9
Brian K Iriye, Kimberly D Gregory, George R Saade, William A Grobman, Haywood L Brown
Providers perceive current obstetric quality measures as imperfect and insufficient. Our organizations convened a "Quality Measures in High-Risk Pregnancies Workshop." The goals were to (1) review the current landscape regarding quality measures in obstetric conditions with increased risk for adverse maternal or fetal outcomes, (2) evaluate the available evidence for management of common obstetric conditions to identify those that may drive the highest impact on outcomes, quality, and value, (3) propose measures for high-risk obstetric conditions that reflect enhanced quality and efficiency, and (4) identify current research gaps, improve methods of data collection, and recommend means of change...
July 20, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28712949/role-of-early-second-trimester-uterine-artery-doppler-screening-to-predict-small-for-gestational-age-babies-in-nulliparous-women
#10
Samuel Parry, Anthony Sciscione, David M Haas, William A Grobman, Jay D Iams, Brian M Mercer, Robert M Silver, Hyagriv N Simhan, Ronald J Wapner, Deborah A Wing, Michal A Elovitz, Frank P Schubert, Alan Peaceman, M Sean Esplin, Steve Caritis, Michael P Nageotte, Benjamin A Carper, George R Saade, Uma M Reddy, Corette B Parker
BACKGROUND: Trophoblastic invasion of the uterine spiral arteries substantially increases compliance to accommodate increased blood flow to the placenta. Failure of this process impedes uterine artery blood flow, and this may be detected by uterine artery Doppler flow studies. However, the clinical utility of uterine artery Doppler flow studies in the prediction of adverse pregnancy outcomes in a general population remains largely unknown. OBJECTIVE: We sought to determine the utility of early second-trimester uterine artery Doppler studies as a predictor of small-for-gestational-age neonates...
July 13, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28649788/pharmacokinetics-and-dynamics-of-mycophenolate-mofetil-after-single-dose-oral-administration-in-juvenile-dachshunds
#11
M Grobman, D M Boothe, H Rindt, B G Williamson, M L Katz, J R Coates, C R Reinero
Mycophenolate mofetil (MMF) is recommended as an alternative/complementary immunosuppressant. Pharmacokinetic and dynamic effects of MMF are unknown in young-aged dogs. We investigated the pharmacokinetics and pharmacodynamics of single oral dose MMF metabolite, mycophenolic acid (MPA), in healthy juvenile dogs purpose-bred for the tripeptidyl peptidase 1 gene (TPP1) mutation. The dogs were heterozygous for the mutation (nonaffected carriers). Six dogs received 13 mg/kg oral MMF and two placebo. Pharmacokinetic parameters derived from plasma MPA were evaluated...
June 25, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28599896/objectively-measured-short-sleep-duration-and-later-sleep-midpoint-in-pregnancy-are-associated-with-a-higher-risk-of-gestational-diabetes
#12
Francesca L Facco, William A Grobman, Kathryn J Reid, Corette B Parker, Shannon M Hunter, Robert M Silver, Robert C Basner, George R Saade, Grace W Pien, Shalini Manchanda, Judette M Louis, Chia-Ling Nhan-Chang, Judith H Chung, Deborah A Wing, Hyagriv N Simhan, David M Haas, Jay Iams, Samuel Parry, Phyllis C Zee
BACKGROUND: Experimental and epidemiologic data suggest that among nonpregnant adults, sleep duration may be an important risk factor for chronic disease. Although pregnant women commonly report poor sleep, few studies objectively evaluated the quality of sleep in pregnancy or explored the relationship between sleep disturbances and maternal and perinatal outcomes. OBJECTIVE: Our objective was to examine the relationship between objectively assessed sleep duration, timing, and continuity (measured via wrist actigraphy) and maternal cardiovascular and metabolic morbidity specific to pregnancy...
June 7, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28578170/can-venous-cord-gas-values-predict-fetal-acidemia
#13
Kate Swanson, Anna R Whelan, William A Grobman, Emily S Miller
BACKGROUND: Umbilical cord arterial blood gas values are used to diagnose fetal acidemia; however, arterial cord blood specimens are frequently not available. OBJECTIVE: We sought to assess whether umbilical cord venous blood gas values can be used to reliably predict fetal acidemia. STUDY DESIGN: This is an observational study of women with a singleton gestation at a single tertiary care hospital who delivered from September 2010 through August 2015 and had both umbilical cord arterial and venous blood gas samples measured...
September 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28526451/interdelivery-weight-gain-and-risk-of-cesarean-delivery-following-a-prior-vaginal-delivery
#14
Annie M Dude, Abbi D Lane-Cordova, William A Grobman
BACKGROUND: Approximately one third of all deliveries in the United States are via cesarean. Previous research indicates weight gain during pregnancy is associated with an increased risk of cesarean delivery. It remains unclear, however, whether and to what degree weight gain between deliveries (ie, interdelivery weight gain) is associated with cesarean delivery in a subsequent pregnancy following a vaginal delivery. OBJECTIVES: The objective of the study was to determine whether interdelivery weight gain is associated with an increased risk of intrapartum cesarean delivery following a vaginal delivery...
September 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28502760/patterns-of-gestational-weight-gain-and-birthweight-outcomes-in-the-eunice-kennedy-shriver-national-institute-of-child-health-and-human-development-fetal-growth-studies-singletons-a-prospective-study
#15
MULTICENTER STUDY
Sarah J Pugh, Paul S Albert, Sungduk Kim, William Grobman, Stefanie N Hinkle, Roger B Newman, Deborah A Wing, Katherine L Grantz
BACKGROUND: Inadequate or excessive total gestational weight gain is associated with increased risks of small- and large-for-gestational-age births, respectively, but evidence is sparse regarding overall and trimester-specific patterns of gestational weight gain in relation to these risks. Characterizing the interrelationship between patterns of gestational weight gain across trimesters can reveal whether the trajectory of gestational weight gain in the first trimester sets the path for gestational weight gain in subsequent trimesters, thereby serving as an early marker for at-risk pregnancies...
September 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28474356/patients-preferences-for-labor-analgesic-counseling-a-qualitative-analysis
#16
Paloma Toledo, Javiera Pumarino, William A Grobman, Cynthia A Wong, Jane L Holl, Romana Hasnain-Wynia
BACKGROUND: The decision to use, or not use, neuraxial labor analgesia is complex, with both maternal and fetal considerations. Fears and concerns about neuraxial analgesia may influence analgesic decision-making. Little is known about patients' preferences for analgesic counseling. Therefore, the objectives of this qualitative study were to evaluate the sources of information used by patients, the timing and content of antepartum counseling about labor analgesia, and patients' preferences for such counseling...
May 5, 2017: Birth
https://www.readbyqxmd.com/read/28450221/mothers-childhood-hardship-forecasts-adverse-pregnancy-outcomes-role-of-inflammatory-lifestyle-and-psychosocial-pathways
#17
Gregory E Miller, Jennifer Culhane, William Grobman, Hyagriv Simhan, Douglas E Williamson, Emma K Adam, Claudia Buss, Sonja Entringer, Kwang-Youn Kim, J Felipe Garcia-Espana, Lauren Keenan-Devlin, Thomas W McDade, Pathik D Wadhwa, Ann Borders
Research suggests the health consequences of economic hardship can be transmitted across generations. Some of these disparities are thought to be passed to offspring during gestation. But this hypothesis has not been tested in contemporary American samples, and the mechanisms of transmission have not been characterized. Accordingly, this study had two goals: first, to determine if women exposed to economic hardship during childhood showed higher rates of adverse birth outcomes; and second, to evaluate the contribution of inflammation, psychosocial, lifestyle, and obstetric characteristics to this phenomenon...
October 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28393386/maternal-depressive-symptoms-perceived-stress-and-fetal-growth
#18
William A Grobman, Deborah A Wing, Paul Albert, Sungduk Kim, Jagteshwar Grewal, Constance Guille, Roger Newman, Edward K Chien, John Owen, Mary E D'Alton, Ronald Wapner, Anthony Sciscione, Katherine L Grantz
OBJECTIVES: To determine whether longitudinal fetal growth is altered among pregnant women reporting greater perceived stress or more symptoms of depression. METHODS: This analysis was based on a multicenter longitudinal study of fetal growth. Women were screened at gestational ages of 8 weeks to 13 weeks 6 days for low-risk status and underwent serial sonographic examinations. At each study visit during pregnancy, women were asked to complete the Cohen Perceived Stress Scale (PSS) and Edinburgh Postpartum Depression Survey (EPDS)...
April 10, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28384838/maternal-income-during-pregnancy-is-associated-with-chronic-placental-inflammation-at-birth
#19
Lauren S Keenan-Devlin, Linda M Ernst, Kharah M Ross, Sameen Qadir, William A Grobman, Jane L Holl, Amy Crockett, Gregory E Miller, Ann E B Borders
Objective This study aims to examine whether maternal household income is associated with histological evidence of chronic placental inflammation. Study Design A total of 152 participants completed surveys of household income and consented to placenta collection at delivery and postpartum chart review for birth outcomes. Placental inflammatory lesions were evaluated via histological examination of the membranes, basal plate, and villous parenchyma by a single, experienced pathologist. Associations between household income and the presence of inflammatory lesions were adjusted for known perinatal risk factors...
August 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28383377/evaluation-of-introduction-of-a-delayed-cord-clamping-protocol-for-premature-neonates-in-a-high-volume-maternity-center
#20
Lilly Y Liu, Joe M Feinglass, Janine Y Khan, Susan E Gerber, William A Grobman, Lynn M Yee
OBJECTIVE: To evaluate adherence to a delayed cord clamping protocol for preterm births in the first 2 years after its introduction, perform a quality improvement assessment, and determine neonatal outcomes associated with protocol implementation and adherence. METHODS: This is a retrospective cohort study of women delivering singleton neonates at 23-32 weeks of gestation in the 2 years before (preprotocol) and 2 years after (postprotocol) introduction of a 30-second delayed cord clamping protocol at a large-volume academic center...
May 2017: Obstetrics and Gynecology
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