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https://www.readbyqxmd.com/read/28419395/choriocapillaris-changes-imaged-by-oct-angiography-after-half-dose-photodynamic-therapy-for-chronic-central-serous-chorioretinopathy
#1
Kyoko Fujita, Akiyuki Kawamura, Mitsuko Yuzawa
BACKGROUND AND OBJECTIVE: To evaluate the choriocapillaris using optical coherence tomographic angiography (OCTA) after half-dose verteporfin photodynamic therapy (hd-PDT) for chronic central serous chorioretinopathy (CSC). PATIENTS AND METHODS: We studied six eyes (six patients) with chronic CSC treated by hd-PDT. OCTA was performed before, 1 week after, and 1 month after hd-PDT. The area of flow abnormality at the choriocapillaris level within the PDT spot after hd-PDT was compared with that before hd-PDT...
April 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28388703/quantitative-oct-angiography-of-the-retinal-microvasculature-and-the-choriocapillaris-in-myopic-eyes
#2
Mayss Al-Sheikh, Nopasak Phasukkijwatana, Rosa Dolz-Marco, Mansour Rahimi, Nicholas A Iafe, K Bailey Freund, SriniVas R Sadda, David Sarraf
Purpose: To study the retinal capillary microvasculature and the choriocapillaris (CC) in myopic eyes using quantitative optical coherence tomography angiography (OCTA) analysis. Methods: Macular OCTA images of 3 × 3 mm were obtained using the RTVue-XR Avanti with AngioVue. Quantitative measurements of the retinal capillary microvascular layers and the CC were analyzed using en face projection images. Vessel density and fractal dimension of the superficial and deep retinal capillary plexus, and area and density of flow reduction in the CC were analyzed, quantified, and compared with an age-matched control group...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28384721/choroidal-vascular-flow-area-in-central-serous-chorioretinopathy-using-swept-source-optical-coherence-tomography-angiography
#3
Massimo Nicolò, Raffaella Rosa, Donatella Musetti, Maria Musolino, Michela Saccheggiani, Carlo Enrico Traverso
Purpose: To report the choroidal vascular flow area in eyes with central serous chorioretinopathy (CSC) compared with healthy subjects and unaffected fellow eyes using swept-source (SS) optical coherence tomography (OCT) angiography. Methods: Prospective case series of 19 eyes of 19 consecutive patients affected by CSC, compared with 15 unaffected fellow eyes and 20 eyes of 10 healthy subjects. Patients underwent SS-OCT angiography in order to evaluate the choroidal vascular flow area of choriocapillaris (CC) and deeper choroidal layers...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28375988/optical-coherence-tomography-angiography-features-of-torpedo-maculopathy
#4
Helena Giannakaki-Zimmermann, Marion R Munk, Chantal Dysli, Andreas Ebneter, Sebastian Wolf, Martin S Zinkernagel
BACKGROUND/PURPOSE: To investigate the retinal and choroidal vasculature in patients with torpedo maculopathy with optical coherence tomography-angiography (OCT-A). METHODS: Retrospective case series of four patients who were examined at the department of Ophthalmology at the University Hospital Bern. Main Outcome was the lesion size over time in OCT-A and fundus autofluorescence. RESULTS: Three patients had Type I and 1 patient had Type II torpedo maculopathy...
April 3, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28336424/the-impact-of-oxidative-stress-and-inflammation-on-rpe-degeneration-in-non-neovascular-amd
#5
REVIEW
Sayantan Datta, Marisol Cano, Katayoon Ebrahimi, Lei Wang, James T Handa
The retinal pigment epithelium (RPE) is a highly specialized, unique epithelial cell that interacts with photoreceptors on its apical side and with Bruch's membrane and the choriocapillaris on its basal side. Due to vital functions that keep photoreceptors healthy, the RPE is essential for maintaining vision. With aging and the accumulated effects of environmental stresses, the RPE can become dysfunctional and die. This degeneration plays a central role in age-related macular degeneration (AMD) pathobiology, the leading cause of blindness among the elderly in western societies...
March 20, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28333572/new-insights-on-complement-inhibitor-cd59-in-mouse-laser-induced-choroidal-neovascularization-mislocalization-after-injury-and-targeted-delivery-for-protein-replacement
#6
Gloriane Schnabolk, Mee Keong Beon, Stephen Tomlinson, Bärbel Rohrer
PURPOSE: The membrane attack complex (MAC) in choriocapillaris (CC) and retinal pigment epithelium (RPE) increase with age and disease (age-related macular degeneration). MAC assembly can be inhibited by CD59, a membrane-bound regulator. Here we further investigated the role of CD59 in murine choroidal neovascularization (CNV), a model involving both CC and RPE, and tested whether CR2-CD59, a soluble targeted form of CD59, provides protection. METHODS: Laser-induced CNV was generated in wild type and CD59a-deficient mice (CD59(-/-))...
March 23, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28331634/multi-modal-imaging-and-anatomic-classification-of-the-white-dot-syndromes
#7
REVIEW
Meisha L Raven, Alexander L Ringeisen, Yoshihiro Yonekawa, Maxwell S Stem, Lisa J Faia, Justin L Gottlieb
The white dot syndromes (WDS) are a diverse group of posterior uveitidies that share similar clinical findings but are unique from one another. Multimodal imaging has allowed us to better understand the morphology, the activity and age of lesions, and whether there is CNV associated with these different ocular pathologies. The "white dot syndromes" and their uveitic masqueraders can now be anatomically categorized based on lesion localization. The categories include local uveitic syndromes with choroidal pathology, systemic uveitic syndromes with choroidal pathology, and multifocal choroiditis with outer retinal/choriocapillaris pathology with uveitis and without uveitis...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28314954/retinal-and-choroidal-vascular-features-in-patients-with-retinitis-pigmentosa-imaged-by-oct-based-microangiography
#8
Kasra A Rezaei, Qinqin Zhang, Chieh-Li Chen, Jennifer Chao, Ruikang K Wang
PURPOSE: To image vascular features of retinitis pigmentosa (RP) using optical coherence tomography angiography (OCTA). METHODS: Patients with RP were imaged by spectral domain optical coherence tomography based angiography (OCTA). The optical microangiography (OMAG) algorithm was applied to scanned datasets to generate 3D OCTA retinal angiograms, i.e., OMAG angiograms. Motion tracking was used to minimize artifacts due to eye movement, and large field of view OMAG angiograms were achieved through a montage scanning protocol...
March 17, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28314832/features-of-the-choriocapillaris-in-myopic-maculopathy-identified-by-optical-coherence-tomography-angiography
#9
Kaori Sayanagi, Yasushi Ikuno, Sato Uematsu, Kohji Nishida
AIM: To describe the choriocapillaris features imaged by optical coherence tomography angiography (OCTA) in eyes with myopic maculopathy. METHODS: In this retrospective, non-invasive, observational case series, 26 eyes with myopic maculopathy and 12 age-matched healthy eyes underwent fluorescein angiography, indocyanine green angiography (ICGA) (highly myopic eyes only), OCT and OCTA, and the choriocapillaris features seen on OCTA and ICGA were compared. RESULTS: In all five (19%) eyes with patchy atrophy of the 26 highly myopic eyes, OCTA showed complete loss of the choriocapillaris and large choroidal vessels in the atrophic area...
March 17, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28301863/optical-coherence-tomography-angiography-in-nonarteritic-anterior-ischemic-optic-neuropathy
#10
Emily Wright Mayes, Emily D Cole, Sabin Dang, Eduardo A Novais, Laurel Vuong, Carlos Mendoza-Santiesteban, Jay S Duker, Thomas R Hedges
BACKGROUND: Optical coherence tomography angiography (OCTA) has demonstrated good utility in qualitative analysis of retinal and choroidal vasculature and therefore may be relevant in the diagnostic and treatment efforts surrounding nonarteritic anterior ischemic optic neuropathy (NAION). METHODS: Retrospective, cross-sectional study of 10 eyes of 9 patients with a previous or new diagnosis of NAION that received imaging with OCTA between November 2015 and February 2016...
March 15, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28281863/multimodal-imaging-including-optical-coherence-tomography-angiography-in-serpiginous-choroiditis
#11
Seong Joon Ahn, Seung Hoon Park, Byung Ro Lee
PURPOSE: To report multimodal imaging in patients with serpiginous choroiditis. METHODS: A 60-year-old woman with active serpiginous choroiditis in the right eye was evaluated during the disease course with multimodal imaging, which included fluorescein angiography, swept-source optical coherence tomography (SS-OCT), OCT angiography, fundus autofluorescence (FAF), and retromode imaging. RESULTS: The patient had subretinal, yellowish lesion on the macula at presentation...
April 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28236003/oct-angiography-quantifying-choriocapillary-circulation-in-idiopathic-macular-hole-before-and-after-surgery
#12
Yufei Teng, Marco Yu, Yi Wang, Xinxin Liu, Qisheng You, Wu Liu
PURPOSE: To investigate the choriocapillary circulation in the macular area for eyes with unilateral idiopathic macular hole (IMH) before and after vitrectomy using optical coherence tomography angiography (OCTA). METHODS: A prospective study of 25 patients with unilateral IMH who underwent vitrectomy and 30 age- and sex-matched healthy controls were recruited. Choriocapillary circulation was measured by OCTA to obtain two measurements: flow area and parafovea vessel density...
February 24, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28198786/optical-coherence-tomography-angiography-in-adult-onset-foveomacular-vitelliform-dystrophy
#13
Komal M Joshi, Peter L Nesper, Amani A Fawzi, Rukhsana G Mirza
PURPOSE: To determine the ability of optical coherence tomography angiography (OCTA) to detect choroidal neovascularization (CNV) in the pseudohypopyon stage of adult-onset foveomacular vitelliform dystrophy. METHODS: Prospective case series of eight consecutive patients with adult-onset foveomacular vitelliform dystrophy with at least one eye in the pseudohypopyon stage (a total of 14 eyes). Patients were assessed with spectral domain OCT, flourescein angiography, and OCTA...
February 14, 2017: Retina
https://www.readbyqxmd.com/read/28171871/effect-of-photodynamic-therapy-on-optical-coherence-tomography-angiography-in-eyes-with-chronic-central-serous-chorioretinopathy
#14
Yishuang Xu, Yu Su, Lu Li, Hang Qi, Hongmei Zheng, Changzheng Chen
PURPOSE: To analyze the use of optical coherence tomography angiography (OCTA) in order to observe the changes in chronic central serous chorioretinopathy (CCSC) after half-dose photodynamic therapy (PDT). METHODS: This is a retrospective study evaluating an imaging technique in a cohort of patients. Fundus photography, fluorescein angiography (FA), indocyanine green angiography (ICGA) (Heidelberg Spectralis, Heidelberg, Germany), OCT, and OCTA with the split-spectrum amplitude-decorrelation angiography algorithm (XR Optovue, Fremont, CA, USA) were performed prior to half-dose PDT...
2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28169877/ising-model-of-choriocapillaris-flow
#15
Richard F Spaide
PURPOSE: To develop a mathematical model of local blood flow in the choriocapillaris using an Ising model. METHODS: A JavaScript Ising model was used to create images that emulated the development of signal voids as would be seen in optical coherence tomography angiography of the choriocapillaris. The model was produced by holding the temperature near criticality and varying the field strength. Individual frames were evaluated, and a movie video was created to show the hypothetical development of flow-related signal voids over a lifetime...
February 6, 2017: Retina
https://www.readbyqxmd.com/read/28159853/vascular-flow-density-in-pathological-myopia-an-optical-coherence-tomography-angiography-study
#16
Jing Mo, Anli Duan, Szyyann Chan, Xuefei Wang, Wenbin Wei
OBJECTIVES: To investigate vascular flow density in pathological myopia with optical coherence tomography (OCT) angiography. DESIGN: A prospective comparative study was conducted from December 2015 to March 2016. SETTING: Participants were recruited in Beijing Tongren Hospital. PARTICIPANTS: A total of 131 eyes were enrolled, which were divided into three groups: 45 eyes with emmetropia (EM; mean spherical equivalent (MSE) 0...
February 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/28151966/optical-coherence-tomography-angiography-findings-in-stargardt-disease
#17
Rodolfo Mastropasqua, Lisa Toto, Enrico Borrelli, Luca Di Antonio, Peter A Mattei, Alfonso Senatore, Marta Di Nicola, Cesare Mariotti
BACKGROUND: to assess vessel density of superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris (CC) in advanced Stargardt disease (STGD) using optical coherence tomography angiography (OCTA) and correlate these findings with macular function using pattern electroretinogram (PERG) and multifocal electroretinogram (mfERG). METHODS: Twelve patients (24 eyes) with advanced STGD underwent vessel densities and macular thickness measurements using OCTA...
2017: PloS One
https://www.readbyqxmd.com/read/28151840/acute-posterior-multifocal-placoid-pigment-epitheliopathy-on-optical-coherence-tomography-angiography
#18
Michael J Heiferman, Safa Rahmani, Lee M Jampol, Peter L Nesper, Dimitra Skondra, Leo A Kim, Amani A Fawzi
PURPOSE: To investigate choroidal involvement in acute posterior multifocal placoid pigment epitheliopathy (APMPPE). METHODS: A retrospective observational case series using multimodal imaging including optical coherence tomography (OCT) angiography. RESULTS: Five patients with APMPPE were included. In most acute lesions, OCT angiography revealed outer retinal and retinal pigment epithelium (RPE) hyperreflective lesions with attenuated OCT signal in the underlying choroid, but careful examination allowed us to identify a single lesion with decreased choriocapillaris flow outside the signal attenuation...
February 1, 2017: Retina
https://www.readbyqxmd.com/read/28146236/subretinal-pigment-epithelial-deposition-of-drusen-components-including-hydroxyapatite-in-a-primary-cell-culture-model
#19
Matthew G Pilgrim, Imre Lengyel, Antonio Lanzirotti, Matt Newville, Sarah Fearn, Eszter Emri, Jonathan C Knowles, Jeffrey D Messinger, Russell W Read, Clyde Guidry, Christine A Curcio
Purpose: Extracellular deposits containing hydroxyapatite, lipids, proteins, and trace metals that form between the basal lamina of the RPE and the inner collagenous layer of Bruch's membrane are hallmarks of early AMD. We examined whether cultured RPE cells could produce extracellular deposits containing all of these molecular components. Methods: Retinal pigment epithelium cells isolated from freshly enucleated porcine eyes were cultured on Transwell membranes for up to 6 months...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28145974/quantitative-analysis-of-optical-coherence-tomography-angiography-in-adult-onset-foveomacular-vitelliform-dystrophy
#20
Maurizio Battaglia Parodi, Alessandro Rabiolo, Maria Vittoria Cicinelli, Pierluigi Iacono, Francesco Romano, Francesco Bandello
PURPOSE: To quantify the foveal avascular zone area at superficial capillary plexus (SCP) and deep capillary plexus (DCP) and the global, parafoveal, and perifoveal vessel densities at SCP, DCP, and choriocapillaris using optical coherence tomography angiography in patients affected by adult-onset foveomacular vitelliform dystrophy (AOFVD). METHODS: Twenty eyes of 20 consecutive patients (10 females, 50%) with AOFVD and 20 eyes of 20 healthy controls presenting at the Department of Ophthalmology of San Raffaele Hospital, Milan, Italy were enrolled...
January 31, 2017: Retina
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