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https://www.readbyqxmd.com/read/27918307/vegf-regulates-local-inhibitory-complement-proteins-in-the-eye-and-kidney
#1
Lindsay S Keir, Rachel Firth, Lyndsey Aponik, Daniel Feitelberg, Susumu Sakimoto, Edith Aguilar, Gavin I Welsh, Anna Richards, Yoshihiko Usui, Simon C Satchell, Valeryia Kuzmuk, Richard J Coward, Jonathan Goult, Katherine R Bull, Ruchi Sharma, Kapil Bharti, Peter D Westenskow, Iacovos P Michael, Moin A Saleem, Martin Friedlander
Outer retinal and renal glomerular functions rely on specialized vasculature maintained by VEGF that is produced by neighboring epithelial cells, the retinal pigment epithelium (RPE) and podocytes, respectively. Dysregulation of RPE- and podocyte-derived VEGF is associated with neovascularization in wet age-related macular degeneration (ARMD), choriocapillaris degeneration, and glomerular thrombotic microangiopathy (TMA). Since complement activation and genetic variants in inhibitory complement factor H (CFH) are also features of both ARMD and TMA, we hypothesized that VEGF and CFH interact...
December 5, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27898981/macular-features-in-retinitis-pigmentosa-correlations-among-ganglion-cell-complex-thickness-capillary-density-and-macular-function
#2
Lisa Toto, Enrico Borrelli, Rodolfo Mastropasqua, Alfonso Senatore, Luca Di Antonio, Marta Di Nicola, Paolo Carpineto, Leonardo Mastropasqua
Purpose: To investigate correlations among macular ganglion cell complex (GCC) layer thickness, macular capillary density, and macular function in patients affected by retinitis pigmentosa (RP). Methods: Fourteen patients (28 eyes) with previous diagnosis of RP were enrolled. The diagnosis of these conditions was made based on both clinical features and electrophysiological examination. All patients underwent a complete ophthalmologic examination, including optical coherence tomography angiography (OCTA) and multifocal electroretinogram (mfERG)...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27867732/dynamic-contrast-optical-coherence-tomography-images-transit-time-and-quantifies-microvascular-plasma-volume-and-flow-in-the-retina-and-choriocapillaris
#3
Conrad W Merkle, Conor Leahy, Vivek J Srinivasan
Despite the prevalence of optical imaging techniques to measure hemodynamics in large retinal vessels, quantitative measurements of retinal capillary and choroidal hemodynamics have traditionally been challenging. Here, a new imaging technique called dynamic contrast optical coherence tomography (DyC-OCT) is applied in the rat eye to study microvascular blood flow in individual retinal and choroidal layers in vivo. DyC-OCT is based on imaging the transit of an intravascular tracer dynamically as it passes through the field-of-view...
October 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27815677/-choroidal-neovascularisation-in-a-patient-with-choroidal-osteoma-visualized-by-oct-angiography
#4
N Mihailovic, M Alnawaiseh, R-L Merté, N Eter
We present the case of a 38-year-old Asian patient who reported vision loss of her left eye since 4 weeks. The funduscopy showed a choroidal tumor in the papillomacular bundle, which could be identified as a choroidal osteoma with secondary choroidal neovascularization (CNV). OCT angiography (OCT-A) detected abnormal flow in the choriocapillaris; the osteoma showed no flow in the OCT angiogram of the choroid level. Therefore, OCT-A can be a helpful adjuvant for diagnosis of CNV secondary to choroidal osteoma...
November 4, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27802521/senescence-increases-choroidal-endothelial-stiffness-and-susceptibility-to-complement-injury-implications-for-choriocapillaris-loss-in-amd
#5
Andrea P Cabrera, Arun Bhaskaran, Jun Xu, Xiao Yang, Harry A Scott, Umar Mohideen, Kaustabh Ghosh
Purpose: Age-related macular degeneration (AMD) commonly causes blindness in the elderly. Yet, it is untreatable in the large fraction of all AMD patients that develop the early dry form. Dry AMD is marked by the deposition of membrane attack complex (MAC) on choriocapillaris (CC), which is implicated in CC degeneration and subsequent atrophy of overlying retinal pigment epithelium. Since MAC is also found on the CC of young eyes, here we investigated whether and how aging increases choroidal endothelial susceptibility to MAC injury...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27800277/objective-determination-of-retinal-function-in-bietti-crystalline-retinopathy
#6
Dorukcan Akıncıoğlu, Ümit Yolcu, Abdullah İlhan, Fatih Çakır Gündoğan
A 44-year-old female patient without any known systemic or ocular disease presented with progressive visual loss and night vision disturbance. Visual acuity was 0.6 in the right eye and 0.2 in the left eye. Tiny, yellow crystalline deposits were seen on fundus examination. In addition, areas of retinal pigment epithelium and choriocapillaris atrophy were detected. Rod and cone responses were depressed in full-field flash electroretinogram. Multifocal electroretinogram testing showed severe foveal function disturbance with less severe but still depressed responses toward the periphery...
June 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/27794427/choriocapillaris-non-perfusion-is-associated-with-poor-visual-acuity-in-eyes-with-reticular-pseudodrusen
#7
Peter L Nesper, Brian T Soetikno, Amani A Fawzi
PURPOSE: To study choriocapillaris blood flow in age-related macular degeneration (AMD) using optical coherence tomography angiography (OCTA) and study its correlation to vision (VA) in eyes with reticular pseudodrusen (RPD) versus those with drusen without RPD (drusen). DESIGN: Cross-sectional study METHODS: Patients with either drusen or RPD in early AMD underwent OCTA imaging of the superior, inferior, and/or nasal macula. We quantified "percent choriocapillaris area of non-perfusion" (PCAN) in eyes with RPD versus those with drusen...
October 26, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27792810/effect-of-uveal-melanocytes-on-choroidal-morphology-in-rhesus-macaques-and-humans-on-enhanced-depth-imaging-optical-coherence-tomography
#8
Glenn Yiu, Vivian S Vuong, Sharon Oltjen, David Cunefare, Sina Farsiu, Laura Garzel, Jeffrey Roberts, Sara M Thomasy
Purpose: To compare cross-sectional choroidal morphology in rhesus macaque and human eyes using enhanced-depth imaging optical coherence tomography (EDI-OCT) and histologic analysis. Methods: Enhanced-depth imaging-OCT images from 25 rhesus macaque and 30 human eyes were evaluated for choriocapillaris and choroidal-scleral junction (CSJ) visibility in the central macula based on OCT reflectivity profiles, and compared with age-matched histologic sections. Semiautomated segmentation of the choriocapillaris and CSJ was used to measure choriocapillary and choroidal thickness, respectively...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27780182/the-spectrum-of-amalric-triangular-choroidal-infarction
#9
Julia Nemiroff, Nopasak Phasukkijwatana, Veronika Vaclavik, Aaron Nagiel, Eric R Holz, David Sarraf
PURPOSE: To describe the multimodal imaging findings, including optical coherence tomography angiography analysis, and spectrum of etiologies associated with Amalric triangular choroidal infarction. METHODS: This study is a multicenter, retrospective, observational case series review of the clinical and multimodal imaging findings for six patients with Amalric triangular choroidal infarction. RESULTS: Six patients (10 eyes) with Amalric triangular choroidal infarction were enrolled...
October 11, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27779556/multimodal-imaging-of-serpiginous-choroiditis
#10
Hashim Ali Khan, Muhammad Aamir Shahzad
PURPOSE: To report a case of atypical serpiginous choroiditis with previously unreported findings on optical coherence tomographic angiography. CASE REPORT: A 35-year-old otherwise healthy man had a 1-week history of vision loss in his right eye. The visual acuity in right eye was counting fingers at 1 meter. Fundoscopy showed a classic peripapillary serpiginous lesion and a solitary macular lesion. Fundus fluorescein angiography revealed early hypofluorescence of active lesions with gradual increase in fluorescence across the phase of angiogram...
October 25, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/27779198/form-shape-and-function-segmented-blood-flow-in-the-choriocapillaris
#11
M A Zouache, I Eames, C A Klettner, P J Luthert
The development of fluid transport systems was a key event in the evolution of animals and plants. While within vertebrates branched geometries predominate, the choriocapillaris, which is the microvascular bed that is responsible for the maintenance of the outer retina, has evolved a planar topology. Here we examine the flow and mass transfer properties associated with this unusual geometry. We show that as a result of the form of the choriocapillaris, the blood flow is decomposed into a tessellation of functional vascular segments of various shapes delineated by separation surfaces across which there is no flow, and in the vicinity of which the transport of passive substances is diffusion-limited...
October 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27755379/analysis-of-age-related-choroidal-layers-thinning-in-healthy-eyes-using-swept-source-optical-coherence-tomography
#12
Jorge Ruiz-Medrano, Ignacio Flores-Moreno, Pablo Peña-García, Javier A Montero, Julián García-Feijóo, Jay S Duker, José M Ruiz-Moreno
PURPOSE: To study the changes in the choroidal layers thickness with age in a healthy population using swept-source optical coherence tomography. METHODS: Retrospective data analysis of a subgroup of eyes from a previous single-center, prospective, cross-sectional, noninterventional study. One hundred and sixty-nine healthy eyes were evaluated using swept-source optical coherence tomography. Inclusion criteria were best-corrected visual acuity between 20/20 and 20/25, spherical equivalent between ±3 diopters, and no systemic or ocular diseases...
October 10, 2016: Retina
https://www.readbyqxmd.com/read/27749785/choroidal-morphology-in-eyes-with-polypoidal-choroidal-vasculopathy-and-normal-or-subnormal-subfoveal-choroidal-thickness
#13
Won Ki Lee, Jiwon Baek, Kunal K Dansingani, Jae Hyung Lee, K Bailey Freund
PURPOSE: To subsegment the choroid in patients with polypoidal choroidal vasculopathy and to determine whether the ratio of choriocapillaris/Sattler layer thickness to total choroidal thickness is decreased at sites of polypoidal pathology. METHODS: Retrospective, observational, cross-sectional study. A total of 320 eyes of 305 patients with polypoidal choroidal vasculopathy were studied with optical coherence tomography and dye angiography. The ratio of choriocapillaris/Sattler layer thickness to total choroidal thickness was calculated at polypoidal lesion sites in eyes with subfoveal choroidal thickness (SFCT) ≤200 μm...
October 3, 2016: Retina
https://www.readbyqxmd.com/read/27749697/swept-source-optical-coherence-tomography-angiography-reveals-choriocapillaris-alterations-in-eyes-with-nascent-geographic-atrophy-and-drusen-associated-geographic-atrophy
#14
Eric M Moult, Nadia K Waheed, Eduardo A Novais, WooJhon Choi, ByungKun Lee, Stefan B Ploner, Emily D Cole, Ricardo N Louzada, Chen D Lu, Philip J Rosenfeld, Jay S Duker, James G Fujimoto
PURPOSE: To investigate choriocapillaris (CC) alteration in patients with nascent geographic atrophy (nGA) and/or drusen-associated geographic atrophy (DAGA) using swept-source optical coherence tomography angiography (OCTA). METHODS: A 1,050-nm wavelength, 400 kHz A-scan rate swept-source optical coherence tomography prototype was used to perform volumetric swept-source optical coherence tomography angiography over 6 mm × 6 mm fields of view in patients with nGA and/or DAGA...
September 30, 2016: Retina
https://www.readbyqxmd.com/read/27748129/-angiography-of-the-ocular-fundus-without-dye-optical-coherence-tomography-based-angiography-in-exsudative-age-related-macular-degeneration
#15
Miklós Resch, Csilla Németh, György Barcsay, Mónika Ecsedy, Ágnes Borbándy, Zsuzsanna Géhl, Anikó Balogh, Antal Szabó, Zoltán Zsolt Nagy, András Papp
INTRODUCTION: Vascular endothelial growth factor antibody therapy is an established treatment of exsudative age-related macular degeneration. AIM: The morphologic characterisation of the macular microvasculature after longstanding treatment. METHOD: Forty-eight patients (34 women and 14 men; age, 74.4 ± 8.0 years) were enrolled in the study. During follow-up time (53.8 ± 31.0 months), 7.6 ± 4.9 injections were administered in 56 eyes. Optical coherence tomography angiographic examination was performed with AngioVue (Optovue Inc...
October 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27741104/optical-coherence-angiography-a-review
#16
Adam Wylęgała, Sławomir Teper, Dariusz Dobrowolski, Edward Wylęgała
BACKGROUND: Retinal vascular diseases are one of the most common causes of blindness in the developed world. Optical Coherence Tomography Angiography (OCT-A) is a new noninvasive method that uses several algorithms to detect blood movement. This enables the creation of high-resolution vascular images with contrast depicting motionless tissue. METHODS: This review presents the results of articles relevant to age-related macular degeneration (AMD), diabetic retinopathy (DR), and OCT-A...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27716746/structural-and-molecular-changes-in-the-aging-choroid-implications-for-age-related-macular-degeneration
#17
K R Chirco, E H Sohn, E M Stone, B A Tucker, R F Mullins
Age-related macular degeneration (AMD) is a devastating disease-causing vision loss in millions of people around the world. In advanced stages of disease, death of photoreceptor cells, retinal pigment epithelial cells, and choroidal endothelial cells (CECs) are common. Loss of endothelial cells of the choriocapillaris is one of the earliest detectable events in AMD, and, because the outer retina relies on the choriocapillaris for metabolic support, this loss may be the trigger for progression to more advanced stages...
October 7, 2016: Eye
https://www.readbyqxmd.com/read/27685015/optical-coherence-tomographic-angiography-in-acute-macular-neuroretinopathy
#18
Aristomenis Thanos, Lisa J Faia, Yoshihiro Yonekawa, Sandeep Randhawa
Importance: Acute macular neuroretinopathy (AMN) is a rare, yet increasingly recognized, entity identified predominantly in young healthy females with acute onset of paracentral scotomas. The exact pathophysiology is unknown but an underlying vascular process is suspected. This study used optical coherence tomographic angiography (OCTA) to assess for any evidence of vascular flow abnormality in the retina or choroid in this elusive disease. Observations: Three eyes from 2 young female patients with classic features of AMN are presented...
September 29, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27639177/early-dietary-therapy-for-long-chain-3-hydroxyacyl-coa-dehydrogenase-deficiency-can-maintain-vision-despite-subnormal-retinal-function
#19
Tero T Kivelä
No abstract text is available yet for this article.
December 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27628426/vascular-abnormalities-in-patients-with-stargardt-disease-assessed-with-optical-coherence-tomography-angiography
#20
Maurizio Battaglia Parodi, Maria Vittoria Cicinelli, Alessandro Rabiolo, Luisa Pierro, Gianluigi Bolognesi, Francesco Bandello
AIMS: To describe the vascular abnormalities in patients affected by Stargardt disease (STGD1) by means of optical coherence tomography angiography (OCT-A). METHODS: Cross-sectional case series, with the following inclusion criteria: diagnosis of STGD1, clear ocular media, and stable fixation. Patients underwent best-corrected visual acuity (BCVA), biomicroscopy, applanation tonometry, short-wavelength fundus autofluorescence (SW-FAF) (HRA Heidelberg, Germany), 3×3 Swept Source OCT-A (Topcon Corporation, Japan)...
September 14, 2016: British Journal of Ophthalmology
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