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Jorge Ruiz-Medrano, Ignacio Flores-Moreno, Pablo Peña-García, Javier A Montero, Julián García-Feijóo, Jay S Duker, José M Ruiz-Moreno
PURPOSE: To study the changes in the choroidal layers thickness with age in a healthy population using swept-source optical coherence tomography. METHODS: Retrospective data analysis of a subgroup of eyes from a previous single-center, prospective, cross-sectional, noninterventional study. One hundred and sixty-nine healthy eyes were evaluated using swept-source optical coherence tomography. Inclusion criteria were best-corrected visual acuity between 20/20 and 20/25, spherical equivalent between ±3 diopters, and no systemic or ocular diseases...
October 10, 2016: Retina
Won Ki Lee, Jiwon Baek, Kunal K Dansingani, Jae Hyung Lee, K Bailey Freund
PURPOSE: To subsegment the choroid in patients with polypoidal choroidal vasculopathy and to determine whether the ratio of choriocapillaris/Sattler layer thickness to total choroidal thickness is decreased at sites of polypoidal pathology. METHODS: Retrospective, observational, cross-sectional study. A total of 320 eyes of 305 patients with polypoidal choroidal vasculopathy were studied with optical coherence tomography and dye angiography. The ratio of choriocapillaris/Sattler layer thickness to total choroidal thickness was calculated at polypoidal lesion sites in eyes with subfoveal choroidal thickness (SFCT) ≤200 μm...
October 3, 2016: Retina
Eric M Moult, Nadia K Waheed, Eduardo A Novais, WooJhon Choi, ByungKun Lee, Stefan B Ploner, Emily D Cole, Ricardo N Louzada, Chen D Lu, Philip J Rosenfeld, Jay S Duker, James G Fujimoto
PURPOSE: To investigate choriocapillaris (CC) alteration in patients with nascent geographic atrophy (nGA) and/or drusen-associated geographic atrophy (DAGA) using swept-source optical coherence tomography angiography (OCTA). METHODS: A 1,050-nm wavelength, 400 kHz A-scan rate swept-source optical coherence tomography prototype was used to perform volumetric swept-source optical coherence tomography angiography over 6 mm × 6 mm fields of view in patients with nGA and/or DAGA...
September 30, 2016: Retina
Miklós Resch, Csilla Németh, György Barcsay, Mónika Ecsedy, Ágnes Borbándy, Zsuzsanna Géhl, Anikó Balogh, Antal Szabó, Zoltán Zsolt Nagy, András Papp
INTRODUCTION: Vascular endothelial growth factor antibody therapy is an established treatment of exsudative age-related macular degeneration. AIM: The morphologic characterisation of the macular microvasculature after longstanding treatment. METHOD: Forty-eight patients (34 women and 14 men; age, 74.4 ± 8.0 years) were enrolled in the study. During follow-up time (53.8 ± 31.0 months), 7.6 ± 4.9 injections were administered in 56 eyes. Optical coherence tomography angiographic examination was performed with AngioVue (Optovue Inc...
October 2016: Orvosi Hetilap
Adam Wylęgała, Sławomir Teper, Dariusz Dobrowolski, Edward Wylęgała
BACKGROUND: Retinal vascular diseases are one of the most common causes of blindness in the developed world. Optical Coherence Tomography Angiography (OCT-A) is a new noninvasive method that uses several algorithms to detect blood movement. This enables the creation of high-resolution vascular images with contrast depicting motionless tissue. METHODS: This review presents the results of articles relevant to age-related macular degeneration (AMD), diabetic retinopathy (DR), and OCT-A...
October 2016: Medicine (Baltimore)
K R Chirco, E H Sohn, E M Stone, B A Tucker, R F Mullins
Age-related macular degeneration (AMD) is a devastating disease-causing vision loss in millions of people around the world. In advanced stages of disease, death of photoreceptor cells, retinal pigment epithelial cells, and choroidal endothelial cells (CECs) are common. Loss of endothelial cells of the choriocapillaris is one of the earliest detectable events in AMD, and, because the outer retina relies on the choriocapillaris for metabolic support, this loss may be the trigger for progression to more advanced stages...
October 7, 2016: Eye
Aristomenis Thanos, Lisa J Faia, Yoshihiro Yonekawa, Sandeep Randhawa
Importance: Acute macular neuroretinopathy (AMN) is a rare, yet increasingly recognized, entity identified predominantly in young healthy females with acute onset of paracentral scotomas. The exact pathophysiology is unknown but an underlying vascular process is suspected. This study used optical coherence tomographic angiography (OCTA) to assess for any evidence of vascular flow abnormality in the retina or choroid in this elusive disease. Observations: Three eyes from 2 young female patients with classic features of AMN are presented...
September 29, 2016: JAMA Ophthalmology
Tero T Kivelä
No abstract text is available yet for this article.
September 17, 2016: Acta Paediatrica
Maurizio Battaglia Parodi, Maria Vittoria Cicinelli, Alessandro Rabiolo, Luisa Pierro, Gianluigi Bolognesi, Francesco Bandello
AIMS: To describe the vascular abnormalities in patients affected by Stargardt disease (STGD1) by means of optical coherence tomography angiography (OCT-A). METHODS: Cross-sectional case series, with the following inclusion criteria: diagnosis of STGD1, clear ocular media, and stable fixation. Patients underwent best-corrected visual acuity (BCVA), biomicroscopy, applanation tonometry, short-wavelength fundus autofluorescence (SW-FAF) (HRA Heidelberg, Germany), 3×3 Swept Source OCT-A (Topcon Corporation, Japan)...
September 14, 2016: British Journal of Ophthalmology
Ari Shinojima, Akiyuki Kawamura, Ryusaburo Mori, Kyoko Fujita, Mitsuko Yuzawa
PURPOSE: To reveal vascular signals at the choriocapillaris level in central serous chorioretinopathy (CSC) using optical coherence tomographic angiography (OCTA). PROCEDURES: We analyzed vascular signals at the choriocapillaris level in 58 CSC and 51 contralateral eyes by OCTA (RTVue XR Avanti with AngioVue; Optovue Inc., Fremont, Calif., USA). Data analysis included age, best corrected visual acuity (BCVA), disease duration and serous retinal detachment (SRD) height...
2016: Ophthalmologica. Journal International D'ophtalmologie
Kevin K Ma, James Lin, Katherine Boudreault, Royce W S Chen, Stephen H Tsang
PURPOSE: To describe findings in a patient with choroideremia (CHM) and his mother, an obligate CHM carrier. METHODS: Case report. RESULTS: A 25-year-old man with nyctalopia and poor peripheral vision since childhood, as well as a family history consistent with an X-linked retinal disorder was diagnosed with CHM. His asymptomatic 50-year-old mother, an obligate carrier, was also examined. Fundus examination of the affected man showed significant atrophy of the choroid and retinal pigment epithelium, whereas the carrier woman showed patchy pigmentary mottling...
September 2, 2016: Retinal Cases & Brief Reports
Aniruddha Agarwal, Kanika Aggarwal, Ankit Deokar, Spoorti Krishna Reddy Mandadi, Simar Rajan Singh, Ramandeep Singh, Aman Sharma, Reema Bansal, Vishali Gupta
PURPOSE: To describe optical coherence tomography angiography (OCTA) features of lesions of tubercular multifocal serpiginoid choroiditis (TB MSC) that developed paradoxical worsening (PW). METHODS: In this prospective study, subjects with TB MSC who developed PW upon initiation of anti-tubercular therapy were included. Multimodal imaging was performed using OCTA, enhanced-depth imaging OCT, fluorescein angiography (FA), and indocyanine green angiography (ICGA)...
September 6, 2016: Ocular Immunology and Inflammation
Alessio Cerquaglia, Barbara Iaccheri, Tito Fiore, Marco Lupidi, Giovanni Torroni, Daniela Fruttini, Claudia Giacalone, Carlo Cagini
PURPOSE: To perform a quantitative analysis of choroidal thickness in patients with Fuchs Uveitis Syndrome (FUS) using enhanced depth imaging optical coherence tomography (EDI-OCT). METHODS: All patients underwent comprehensive ophthalmic examination, including best-corrected visual acuity, slit-lamp biomicroscopy, applanation tonometry, axial length measurements with a swept-source biometer (IOLMaster 700, Carl Zeiss Medic AG, Jena, Germany) and macular 30° linear EDI- B-scan SD-OCT section (Spectralis HRAII+OCT, Heidelberg Engineering, Heidelberg, Germany) in both eyes...
October 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
Raimondo Forte, Florent Aptel, Audrey Feldmann, Christophe Chiquet
BACKGROUND: Posterior polar annular choroidal dystrophy (PPACD) is a rare disease. Patients with PPACD show loss of retinal pigment epithelium and choriocapillaries surrounding the vascular arcades and optic nerve. METHODS: Two patients with PPACD were evaluated with multimodal imaging, including fundus autofluorescence (FAF) and adaptive optics (AO). REPORT OF CASES: One patient (32 year old, one eye) with PPACD was followed up for 3 years...
August 30, 2016: Retinal Cases & Brief Reports
Jesse J Jung, Michael H Chen, Soraya Rofagha, Scott S Lee
PURPOSE: To report the multimodal imaging findings and follow-up of a case of graft-versus-host disease-induced bilateral panuveitis and serous retinal detachments after allogenic bone marrow transplant for acute myeloid leukemia. METHODS: A 75-year-old black man presented with acute decreased vision in both eyes for 1 week. Clinical examination and multimodal imaging, including spectral domain optical coherence tomography, fundus autofluorescence, fluorescein angiography, and swept-source optical coherence tomography angiography (Investigational Device; Carl Zeiss Meditec Inc) were performed...
August 26, 2016: Retinal Cases & Brief Reports
WooJhon Choi, Nadia K Waheed, Eric M Moult, Mehreen Adhi, ByungKun Lee, Talisa De Carlo, Vijaysekhar Jayaraman, Caroline R Baumal, Jay S Duker, James G Fujimoto
PURPOSE: To investigate the utility of ultrahigh speed, swept source optical coherence tomography angiography in visualizing retinal microvascular and choriocapillaris (CC) changes in diabetic patients. METHODS: The study was prospective and cross-sectional. A 1,050 nm wavelength, 400 kHz A-scan rate swept source optical coherence tomography prototype was used to perform volumetric optical coherence tomography angiography of the retinal and CC vasculatures in diabetic patients and normal subjects...
August 23, 2016: Retina
Francesco Pichi, Sunil K Srvivastava, Saradha Chexal, Andrea Lembo, Luiz H Lima, Piergiorgio Neri, Andrea Saitta, Jay Chhablani, Thomas A Albini, Paolo Nucci, K Bailey Freund, Hyewon Chung, Careen Y Lowder, David Sarraf
PURPOSE: To localize the various levels of abnormalities in multiple evanescent white dot syndrome by comparing "en face" optical coherence tomography (OCT) and OCT angiography with various conventional imaging modalities. METHODS: In this retrospective case series, multimodal imaging was performed in 9 retinal centers on 36 patients with multiple evanescent white dot syndrome and included widefield fundus autofluorescence (FAF), fluorescein angiography (FA), and indocyanine green angiography, and B-scan and "en face" C-scan enhanced depth imaging and spectral domain OCT...
August 22, 2016: Retina
Mark Lane, Eric M Moult, Eduardo A Novais, Ricardo N Louzada, Emily D Cole, ByungKun Lee, Lennart Husvogt, Pearse A Keane, Alastair K Denniston, André J Witkin, Caroline R Baumal, James G Fujimoto, Jay S Duker, Nadia K Waheed
PURPOSE: To investigate the appearance of choriocapillaris (CC) flow under drusen by comparing long-wavelength (1050 nm) swept-source optical coherence tomography (SS-OCT) angiography with shorter-wavelength (840 nm) spectral-domain (SD) OCT angiography. METHODS: Patients with drusen imaged on both devices on the same day were selected and graded. Ambiguous OCT angiography (OCTA) signal loss was defined as low OCTA signal on the en face OCTA CC image that also had low OCT signal in the corresponding area on the en face OCT CC image and OCT B-scans...
July 1, 2016: Investigative Ophthalmology & Visual Science
Anders Kvanta, Manuel Casselholm de Salles, Urban Amrén, Hammurabi Bartuma
PURPOSE: To examine the retinal and choroidal foveal and parafoveal vasculature in patients with bilateral geographic atrophy (GA) secondary to age-related macular degeneration using optical coherence tomography angiography (OCTA). METHODS: Fourteen eyes from 7 patients with and without fovea-sparing bilateral GA at St. Erik Eye Hospital. All patients were examined by optical coherence tomography angiography, en face OCT and fundus autofluorescence (FAF). Segmented optical coherence tomography angiography flow scans were obtained from the superficial retinal vascular layer (SL) and the choriocapillaris (CC) and correlated with areas of retinal pigment epithelial (RPE) loss on fundus autofluorescence...
August 16, 2016: Retina
Ari Shinojima, Kyoko Fujita, Ryusaburo Mori, Akiyuki Kawamura, Mitsuko Yuzawa, Tsutomu Yasukawa
PURPOSE: To identify locations of hypofluorescent lesions on late-phase indocyanine green angiography (ICGA) in patients with central serous chorioretinopathy (CSC) using en-face optical coherence tomography (OCT). PROCEDURES: We retrospectively studied 25 consecutive untreated CSC patients, using swept-source OCT and ICGA. En-face swept-source OCT images were automatically segmented and flattened with Bruch's membrane (BrM). We compared the sizes of hyperreflective areas in the 25 CSC and 25 contralateral eyes on en-face images and hypofluorescent areas on ICGA after 30 min...
2016: Ophthalmologica. Journal International D'ophtalmologie
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