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choriocapillaris

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https://www.readbyqxmd.com/read/29774302/ocular-histopathology-and-immunohistochemical-analysis-in-the-oldest-known-individual-with-autosomal-dominant-vitreoretinochoroidopathy
#1
Morton F Goldberg, Scott McLeod, Mark Tso, Kirk Packo, Malia Edwards, Imran A Bhutto, Rajkumar Baldeosingh, Charles Eberhart, Bernhard H F Weber, Gerard A Lutty
Purpose: To assess the immunohistochemical and histopathological changes in a subject with Autosomal Dominant Vitreoretinochoroidopathy (ADVIRC). Design: Case study. Participant: Ninety two year-old Caucasian male with ADVIRC. Methods: The subject was documented clinically for 54 Years. The retina/choroid complex of the right eye was evaluated with cryosections stained with hematoxylin and eosin or periodic acid schiff reagent...
April 2018: Ophthalmology Retina
https://www.readbyqxmd.com/read/29772051/optical-coherence-tomography-angiography-of-pigmented-paravenous-retinochoroidal-atrophy
#2
Maria Vittoria Cicinelli, Chiara Giuffrè, Alessandro Rabiolo, Maurizio Battaglia Parodi, Francesco Bandello
A 58-year-old man with bilateral pigmented paravenous retinochoroidal atrophy (PPRCA) associated with macular coloboma in the right eye underwent color fundus photography and fundus autofluorescence with the California ultra-widefield retinal imaging system (Optos, Dunfermline, UK), spectral-domain optical coherence tomography (SD-OCT) (Heidelberg Spectralis HRA + OCT; Heidelberg Engineering, Heidelberg, Germany), and en face OCT angiography (OCTA) (AngioPlex, Cirrus HD-OCT 5000; Carl Zeiss Meditec, Dublin, CA)...
May 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29770904/deferoxamine-induced-electronegative-erg-responses
#3
Ruben Jauregui, Karen Sophia Park, Alexander G Bassuk, Vinit B Mahajan, Stephen H Tsang
PURPOSE: To report a case of deferoxamine-induced retinopathy characterized by electroretinography (ERG), optical coherence tomography angiography (OCT-A), and other multimodal imaging. METHODS: This is an observational case report of one patient. Full-field ERG was performed. OCT-A, spectral-domain optical coherence tomography (SD-OCT), color fundus photography, and fundus autofluorescence were used to characterize the retinopathy induced by deferoxamine use. RESULTS: A 64-year-old man with a history of β-thalassemia intermedia presented with worsening visual acuity, nyctalopia, and electronegative ERG...
May 16, 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/29746415/histology-of-geographic-atrophy-secondary-to-age-related-macular-degeneration-a-multilayer-approach
#4
Miaoling Li, Carrie Huisingh, Jeffrey Messinger, Rosa Dolz-Marco, Daniela Ferrara, K Bailey Freund, Christine A Curcio
PURPOSE: To systematically characterize histologic features of multiple chorioretinal layers in eyes with geographic atrophy, or complete retinal pigment epithelium (RPE) and outer retinal atrophy, secondary to age-related macular degeneration, including Henle fiber layer and outer nuclear layer; and to compare these changes to those in the underlying RPE-Bruch membrane-choriocapillaris complex and associated extracellular deposits. METHODS: Geographic atrophy was delimited by the external limiting membrane (ELM) descent towards Bruch membrane...
May 3, 2018: Retina
https://www.readbyqxmd.com/read/29746411/reduced-choriocapillaris-flow-in-eyes-with-type-3-neovascularization-and-age-related-macular-degeneration
#5
Enrico Borrelli, Eric H Souied, K Bailey Freund, Giuseppe Querques, Alexandra Miere, Orly Gal-Or, Riccardo Sacconi, SriniVas R Sadda, David Sarraf
PURPOSE: To study choriocapillaris (CC) flow in eyes with Type 3 neovascularization (NV) and age-related macular degeneration, using optical coherence tomography angiography analysis. METHODS: In this multicenter, retrospective, observational study, we collected data from 21 patients with unilateral Type 3 NV and age-related macular degeneration, based on clinical examination, structural optical coherence tomography, and fluorescein angiography when available. An additional group of 20 nonneovascular age-related macular degeneration eyes with unilateral Type 1 or Type 2 NV due to age-related macular degeneration was included for comparison...
April 30, 2018: Retina
https://www.readbyqxmd.com/read/29715368/cross-inhibition-of-norrin-and-tgf-%C3%AE-signaling-modulates-development-of-retinal-and-choroidal-vasculature
#6
Roswitha Seitz, Gregor Weber, Sebastian Albrecht, Rudolf Fuchshofer, Ernst R Tamm, Andreas Ohlmann
Purpose: Norrin is essential for the formation of the retinal vasculature during development and promotes its repair after damage via activation of Wnt/β-catenin signaling. Since retinal TGF-β signaling has essentially opposite effects on the retinal vasculature we investigated if and how Norrin inhibits TGF-β signaling, and vice versa. Methods: Eyes from transgenic mice with an overexpression of Norrin (βB1-Norrin) and/or active TGF-β (βB1-TGF-β1) in the lens were generated and analyzed by light microscopy, immunohistochemistry, and TUNEL...
May 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29675326/compact-akinetic-swept-source-optical-coherence-tomography-angiography-at-1060-nm-supporting-a-wide-field-of-view-and-adaptive-optics-imaging-modes-of-the-posterior-eye
#7
Matthias Salas, Marco Augustin, Franz Felberer, Andreas Wartak, Marie Laslandes, Laurin Ginner, Michael Niederleithner, Jason Ensher, Michael P Minneman, Rainer A Leitgeb, Wolfgang Drexler, Xavier Levecq, Ursula Schmidt-Erfurth, Michael Pircher
Imaging of the human retina with high resolution is an essential step towards improved diagnosis and treatment control. In this paper, we introduce a compact, clinically user-friendly instrument based on swept source optical coherence tomography (SS-OCT). A key feature of the system is the realization of two different operation modes. The first operation mode is similar to conventional OCT imaging and provides large field of view (FoV) images (up to 45° × 30°) of the human retina and choroid with standard resolution...
April 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29664989/choroidal-caverns-a-previously-unreported-optical-coherence-tomography-finding-in-best-vitelliform-dystrophy
#8
Adriano Carnevali, Riccardo Sacconi, Eleonora Corbelli, Lea Querques, Francesco Bandello, Giuseppe Querques
Best vitelliform macular dystrophy (VMD) is an autosomal dominant inherited dystrophy, most frequently caused by mutations in the BEST1 gene. The authors describe "choroidal caverns," a previously unreported optical coherence tomography finding in the choriocapillary and choroid of Best VMD. Histopathologic examination in eyes with Best VDM shows extensive deposition of lipofuscin in the retinal pigment epithelium (RPE) throughout the retina and accumulation of fibrillar material under the RPE and in the choroid...
April 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29661534/a-new-chlorin-formulation-promotes-efficient-photodynamic-action-in-choriocapillaris-of-rabbit-s-eyes
#9
Gustavo H A Salomao, Adjaci U Fernandes, Mauricio S Baptista, João Paulo Tardivo, Stella Gianssante, Juliana Mora Veridiano, Olga Maria S Toledo, Giuliana Petri, Denise Maria Christofolini, João Antonio Correa
Age-related macular degeneration (AMD) as well as other choroidal diseases, demand novel therapeutic methods. Photodynamic therapy (PDT), which uses light and photosensitizer (PS) to cause specific vascular occlusion in the macula, is an interesting alternative. The only drug approved for the PDT treatment of AMD (Verteporfin) has a natural tendency to aggregate, demanding an expensive separation procedure during purification. We report a novel and affordable PS that is intrinsically protected against aggregation, the Monomeric Chlorin at High Concentration (MCHC-Chlorin), whose liposomal formulation was developed to provoke effective photodynamic action on the choroidal vasculature...
April 4, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29657836/resistive-index-of-ophthalmic-artery-correlates-with-retinal-pigment-epithelial-alterations-on-spectral-domain-optical-coherence-tomography-in-diabetic-retinopathy
#10
Manila Khatri, Sandeep Saxena, Apjit Kaur, Shashi K Bhasker, Manoj Kumar, Carsten H Meyer
Background: Retinal pigment epithelium (RPE) plays a significant role in maintenance of integrity of retinal photoreceptors and choriocapillaries. RPE derives its blood supply through ophthalmic artery (OA) via choriocapillaries. RPE topographic alterations have been observed to be associated with severity of retinopathy. The present study was undertaken to assess the correlation between resistive index (RI) of the OA with RPE topographic alterations on Spectral-Domain optical coherence tomography (SD-OCT), to our knowledge, it is for the first time...
2018: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/29656284/findings-of-optical-coherence-tomography-angiography-in-best-vitelliform-macular-dystrophy
#11
Xiao Na Wang, Qi Sheng You, Qian Li, Yang Li, Yu Mao, Feng Hu, Hui Ying Zhao, Frank F Tsai, Xiao Yan Peng
PURPOSE: To evaluate the vascular anatomy of eyes with Best vitelliform macular dystrophy (BVMD) using optical coherence tomography angiography (OCTA). METHODS: This retrospective case-control study enrolled 11 consecutive BVMD patients and 13 age-matched healthy participants. Both eyes of each participant were imaged using a macular OCTA scan (3 × 3 mm) by 70-kHz 840-nm spectral-domain OCT. The flow signal was calculated using the split-spectrum amplitude-decorrelation angiography (SSADA) algorithm...
April 13, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29651346/choriocapillaris-loss-in-advanced-age-related-macular-degeneration
#12
REVIEW
Carlos A Moreira-Neto, Eric M Moult, James G Fujimoto, Nadia K Waheed, Daniela Ferrara
The purpose of this review is to summarize the current knowledge on choriocapillaris loss in advanced age macular degeneration (AMD). Several histopathological studies in animal models and human eyes had showed that the choriocapillaris density decreases with age. However, the role of choriocapillaris loss is still unclear in AMD and its advanced forms, either choroidal neovascularization (CNV) or geographic atrophy (GA). Some authors have hypothesized that choriocapillaris loss might precede overt retinal pigment epithelium atrophy...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29623721/evaluation-of-ocular-perforation-during-retrobulbar-block-using-high-resolution-spectral-domain-optical-coherence-tomography-and-optical-coherence-tomography-angiography
#13
Stanislao Rizzo, Ruggero Tartaro, Lucia Finocchio, Andrea Giorni, Daniela Bacherini, Alfonso Savastano
INTRODUCTION: This article reports a case of ocular perforation during a retrobulbar block in a patient who underwent scleral buckle for retinal detachment. METHODS: Sterile air was immediately injected into the vitreous cavity to restore intraocular pressure and the scleral buckle operation was quickly finished. One week later, a laser retinopexy was performed on the two retinal holes that were outside the foveal area. After 6 months, spectral domain-optical coherence tomography and optical coherence tomography angiography were performed on the perforated wall centered on the exit hole area...
March 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29620233/a-frameshift-mutation-in-the-chm-gene-causes-choroideremia-with-acute-angle%C3%A2-closure-glaucoma
#14
Pingbo Ouyang, Yun Li, Feng Zhang, Chengzhang Zhu, Beiji Zou, Jianlan Le, Lusi Zhang
Choroideremia is an X‑linked recessive chorioretinal degenerative disease that is characterized by progressive centripetal loss of the photoreceptor, retinal pigment epithelium (RPE), and choriocapillaris layers. The CHM gene [choroideremia (Rab escort protein 1)] has been identified as the pathogenic gene in choroideremia. The aim of the present study was to describe the clinical and genetic characteristics of a family with choroideremia family. In the present study, a family with choroideremia presenting with serious chorioretinal atrophy and pigment proliferation, shallow anterior chambers, angle closure and high intraocular pressure (IOP) were recruited...
April 5, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29600178/the-optic-nerve-head-perfusion-and-its-correlation-with-the-macular-blood-perfusion-in-unilateral-idiopathic-macular-hole-an-optical-coherence-tomography-angiography-study
#15
Xin-Xin Liu, Yu-Fei Teng, Meng Gao, Xi-Da Liang, Yan-Ping Yu, Wu Liu
AIM: To compare the optic nerve head (ONH) perfusion in both eyes of unilateral idiopathic macular hole (IMH) with normal control group by using optical coherence tomography angiography (OCTA) and investigate its correlationship with the macular blood perfusion. METHODS: We performed a prospective and cross-sectional study that included 19 patients with full-thickness unilateral IMH and 24 age- and sex-matched controls. All participants received OCTA test. The ONH perfusion was evaluated by the regions of peripapillary and whole en face (the sum of peripapillary and optic disc)...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29571629/partial-retinal-photoreceptor-loss-in-a-transgenic-mouse-model-associated-with-reduced-levels-of-interphotoreceptor-retinol-binding-protein-irbp-rbp3
#16
Yi-Hsia Liu, Clare Corbett, Izabela P Klaska, Kimmo Makinen, John M Nickerson, Richard J Cornall, Lucia Kuffova, John V Forrester
Organ-specific transgenic membrane expression of hen egg lysozyme (HEL) as a "neo-self antigen" has been used in several models to study immunological tolerance. In this study we report the changes which occur in the B10.BR mouse retina when membrane-bound HEL is expressed in photoreceptors under the control of the promoter for interphotoreceptor retinoid binding protein (IRBP, RBP3). On direct clinical examination of the single transgenic (sTg-IRBP:HEL) mouse fundus, a low-level increase in retinal degeneration compared to non-transgenic controls was observed, presenting as drusenoid deposits and occasional small patches of atrophy...
March 20, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29555028/molecular-genetics-%C3%A2-characterization-and-homology-modeling-of-the-chm-gene-mutation-a-study-on-its-association-with-choroideremia
#17
REVIEW
Saber Imani, Iqra Ijaz, Marzieh Dehghan Shasaltaneh, Shangyi Fu, Jingliang Cheng, Junjiang Fu
Choroideremia (CHM) is a rare form of X-linked chorioretinal dystrophy that is caused by mutations in the CHM gene. Mutations in the Rab escort protein-1 (REP-1), an ubiquitously encoded protein of the CHM gene, lead to prenylation and vesicle trafficking deficiency in the protein, resulting in the progressive degeneration of choriocapillaris, retinal pigment epithelium (RPE), and photoreceptors. Despite previous studies concerning this disease, no effective diagnostic tests or established therapeutic interventions currently exist for CHM...
January 2018: Mutation Research
https://www.readbyqxmd.com/read/29554817/dark-and-white-lesions-observed-in-central-serous-chorioretinopathy-on-optical-coherence-tomography-angiography
#18
Flore De Bats, Pierre-Loïc Cornut, Benjamin Wolff, Laurent Kodjikian, Martine Mauget-Faÿsse
PURPOSE: To describe abnormal dark (hyposignal) and white (hypersignal) lesions observed on optical coherence tomography angiography in central serous chorioretinopathy. METHODS: Prospective, multicenter, and descriptive study including patients with active or quiescent central serous chorioretinopathy. All patients had undergone a complete ophthalmic examination. RESULTS: Abnormal dark lesions were detected as "dark spots" and "dark areas" on optical coherence tomography angiography...
March 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29554384/evaluation-of-choroidal-hemangioma-and-treatment-with-photodynamic-therapy-by-using-enhanced-depth-imaging-optical-coherence-tomography
#19
Zeynep Gursel Ozkurt, Naziha Salimani, Hakan Demirci
BACKGROUND AND OBJECTIVE: To evaluate enhanced depth imaging optical coherence tomography (EDI-OCT) features of choroidal hemangioma and changes following photodynamic therapy (PDT). PATIENTS AND METHODS: Retrospective review of 21 choroidal hemangiomas. RESULTS: On EDI-OCT, choroidal hemangioma showed low internal reflectivity in 47% of lesions and high internal reflectivity in 53%. The most common associated features were normal-looking honeycomb-like pattern in choriocapillaris in all lesions, inner segment/outer segment abnormality in 62%, photoreceptor outer segment abnormality in 62%, subretinal fluid with speckles in 62%, and shaggy photoreceptors in 57% of lesions...
March 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29554052/presentation-of-central-serous-chorioretinopathy-in-two-husband-and-wife-couples
#20
Aditya Kanesa-Thasan, Amani A Fawzi, Manjot K Gill
PURPOSE: Central serous chorioretinopathy (CSC) is a disease in which serous detachment of the neurosensory retina occurs over an area of leakage from the choriocapillaris through the retinal pigment epithelium. Associations have been drawn between high-stress personality types and steroid exposure. This article aims to describe a unique case series of two husband and wife couples with CSC. METHODS: All methods were approved by the authors' institution's institutional review board...
April 2018: Retinal Cases & Brief Reports
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