keyword
MENU ▼
Read by QxMD icon Read
search

HSIL

keyword
https://www.readbyqxmd.com/read/28643492/human-papillomavirus-genotype-distribution-among-18-815-women-in-13-korean-cities-and-relationship-with-cervical-cytology-findings
#1
Eun Hee Nah, Seon Cho, Suyoung Kim, Han Ik Cho
BACKGROUND: The prevalence and genotype distribution of Human papillomavirus (HPV) infection vary depending on geographical region and the immunity provided by vaccines. This study aimed to clarify the recent prevalence and genotype distribution of HPV according to age and cervical cytology findings in Korea. METHODS: This study included 18,815 health examinees that underwent cervical cytology and HPV genotyping tests at 16 centers of Korean Association of Health Promotion in 13 cities in Korea, between January 2014 and October 2015...
September 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28626767/closer-to-a-uniform-language-in-colposcopy-study-on-the-potential-application-of-2011-international-federation-for-cervical-pathology-and-colposcopy-terminology-in-clinical-practice
#2
Yanyun Li, Xiaoling Duan, Long Sui, Fengying Xu, Shuifang Xu, Hongwei Zhang, Congjian Xu
As the newest colposcopic terminology, the 2011 International Federation for Cervical Pathology and Colposcopy (IFCPC) classification provides standardized interpretation of colposcopic findings. In this study, we analyzed the colposcopic accuracy and the significance of individual findings according to the 2011 IFCPC classification in 525 patients, reviewed by 13 trained colposcopists. Results show that colposcopic diagnoses are in 64.95% perfect agreement with cervical pathology, with 63.64% sensitivity and 96...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28622120/trends-in-pap-test-practices-and-results-an-11%C3%A2-year-review-of-the-annual-acha-pap-test-and-sti-survey
#3
Heather P Eastman-Mueller, Sara B Oswalt
OBJECTIVE: To conduct a trend analysis of Pap test practices, Pap test results and related women's services and guidelines of college health centers. PARTICIPANTS: College health centers who participated in the annual ACHA Pap Test and STI Survey years 2004 to 2014 (n ranged from 127 to 181 depending on year). METHODS: Descriptive analyses are presented with ANOVAs and chi-square tests calculated to examine trends over time. RESULTS: The number of Pap tests significantly decreased over time; however, the percentage of normal and HSIL results did not vary...
June 16, 2017: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/28605400/proposed-terminology-for-anal-squamous-lesions-its-application-and-interobserver-agreement-among-pathologists-in-academic-and-community-hospitals
#4
Andres A Roma, Xiuli Liu, Deepa T Patil, Hao Xie, Daniela Allende
Objectives: To analyze interobserver reproducibility and compare practice patterns between academic and community settings of Lower Anogenital Squamous Terminology (LAST). Methods: In total, 132 anal biopsy slides were revised as well as p16 immunostains. Results: LAST was used in 49% of cases (academic center, 68%; satellite hospitals [community practice setting], 32%). After pathology review and consensus interpretation, 23 (17%) case diagnoses were reclassified: eight (34...
June 12, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28603542/-low-grade-squamous-intraepithelial-lesion-cannot-exclude-high-grade-tbs-says-don-t-use-it-should-i-really-stop-it
#5
Jeanine M Chiaffarano, Melissa Alexander, Robert Rogers, Fang Zhou, Joan Cangiarella, Melissa Yee-Chang, Paul Elgert, Aylin Simsir
BACKGROUND: The Bethesda System uses a two-tiered approach in the diagnosis of cervical squamous intraepithelial lesions (SILs). Occasionally, Papanicolaou (Pap) tests with evident low-grade SIL (LSIL) also have some features suggestive but not diagnostic of high-grade SIL (HSIL). This study reviews our experience with "Low-grade Squamous Intraepithelial Lesion, Cannot Exclude High-grade" (LSIL-H) and discusses the best approach to report such Paps if the LSIL-H interpretation is abandoned...
2017: CytoJournal
https://www.readbyqxmd.com/read/28594305/potential-impact-of-a-nonavalent-hpv-vaccine-on-hpv-related-low-and-high-grade-cervical-intraepithelial-lesions-a-referral-hospital-based-study-in-sicily
#6
Giuseppina Capra, Lucia Giovannelli, Domenica Matranga, Carmelina Bellavia, Maria Francesca Guarneri, Teresa Fasciana, Giovanna Scaduto, Alberto Firenze, Alessandra Vassiliadis, Antonio Perino
While bivalent and quadrivalent HPV vaccines have been used for about 10 years, a nonavalent vaccine against HPV types 6/11/16/18/31/33/45/52 and 58 has been recently approved by FDA and EMA and is now commercially available. The objective of our study was to evaluate the potential impact of the nonavalent vaccine on HPV infection and related low- and high-grade squamous intraepithelial lesions (LSIL, HSIL), compared to the impact of the quadrivalent vaccine, in a female population living in Sicily (Italy)...
June 8, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28580567/cytohistological-discrepancies-of-cervico-vaginal-smears-and-hpv-status
#7
İbrahim Alanbay, Mustafa Öztürk, Fahri Burçin Fıratlıgil, Kazım Emre Karaşahin, Müfit Cemal Yenen, Serkan Bodur
OBJECTIVES: Discrepancies between abnormal cervical cytology or high-risk human papillomavirus (HR-HPV) status (cytolo-gy negative/HPV positive) and subsequent histological findings are a common occurrence. After using co-testing, the dis-crepancies between the HR-HPV status and cervical cytology have become an issue. In this study, we aimed to determine the characteristics of women with a discrepancy between histology and cytology/HR-HPV status, in terms of diagnosis, review and identification...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28574670/performance-of-aptima-and-cobas-hpv-testing-platforms-in-detecting-high-grade-cervical-dysplasia-and-cancer
#8
Yimin Ge, Paul Christensen, Eric Luna, Donna Armylagos, Mary R Schwartz, Dina R Mody
BACKGROUND: Human papillomavirus (HPV) tests and genotyping have been used in clinical risk assessment. The purpose of this study was to analyze the performance of 2 common HPV testing platforms in detecting high-grade cervical lesions (high-grade squamous intraepithelial lesion [HSIL] or worse [≥HSIL]). METHODS: Between January 1 and December 31, 2015, 2041 Papanicolaou (Pap) tests with biopsy confirmation were analyzed along with HPV tests performed on Cobas or Aptima platforms...
June 2, 2017: Cancer
https://www.readbyqxmd.com/read/28554573/clinical-significance-of-ck7-hpv-l1-and-koilocytosis-for-patients-with-cervical-low-grade-squamous-intraepithelial-lesions-a-retrospective-analysis
#9
Lanqing Cao, Ping-Li Sun, Min Yao, Shifan Chen, Hongwen Gao
Most cervical low-grade squamous intraepithelial lesions (LSILs) do not progress to high-grade squamous intraepithelial lesions (HSILs); however, reliable biomarkers that predict LSIL progression are lacking. We investigated the association of cytokeratin 7 (CK7), human papillomavirus-L1 capsid protein (HPV-L1), and koilocytosis with clinical outcomes of patients with LSIL. CK7, HPV-L1, Ki67, and p16-INK4A expression was determined in 72 cervical LSIL and 28 HSIL biopsy samples; koilocytosis was evaluated by reviewing biopsy slides...
May 26, 2017: Human Pathology
https://www.readbyqxmd.com/read/28521481/increased-methylation-of-human-papillomavirus-type-16-dna-is-associated-with-the-severity-of-cervical-lesions-in-infected-females-from-northeast-china
#10
Wei Wang, Zhengrong Sun, Jianhua Liu, Guili Wang, Zhitao Lu, Weiqiang Zhou, Te Qi, Qiang Ruan
Hypermethylation of the cytosine-phosphate-guanine (CpG) sites located at the 3'-major capsid protein L1 (3'L1) and the long control region (LCR) of the human papillomavirus (HPV) genome may be associated with the progression of cervical cancer (CC). However, the methylation status of the LCR of HPV type 16 DNA remains to be elucidated in an infected Chinese population. The aim of the present study was to investigate the association between methylation of the HPV 16 L1 gene and LCR, and the severity of cervical lesions in infected female patients...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28521315/p16-ki-67-immunocytochemistry-in-gynecological-cytology-limitations-in-practice
#11
Peter Ziemke
OBJECTIVE: Immunochemical detection of the protein p16INK4a in cervical cytology is used in combination with Ki-67. Cells positive for both proteins are certain to have been transformed by high-risk HPV. p16/Ki-67 immunocytochemistry provides a significant improvement in specificity over cytology and HPV DNA testing. However, p16/Ki-67 immunocytochemistry also has its limitations. STUDY DESIGN: The research is based on the follow-up of 1,131 patients for whom p16/Ki-67 immunocytochemistry was performed with cytology...
2017: Acta Cytologica
https://www.readbyqxmd.com/read/28515108/a-comparison-of-the-natural-history-of-hpv-infection-and-cervical-abnormalities-among-hiv-positive-and-hiv-negative-women-in-senegal-africa
#12
Hilary K Whitham, Stephen E Hawes, Haitao Chu, J Michael Oakes, Alan R Lifson, Nancy B Kiviat, Papa Salif Sow, Geoffrey S Gottlieb, Selly Ba, Marie P Sy, Shalini L Kulasingam
Background: There is evidence of an interaction between HIV and human papillomavirus (HPV) resulting in increased HPV-associated morbidity and cancer mortality among HIV-positive women. This study aims to determine how the natural history of cervical HPV infection differs by HIV status.Methods: A total of 1,320 women (47% were positive for HIV-1 and/or HIV-2) were followed for an average of two years in Senegal, West Africa between 1994 and 2010. Cytology (with a sub-sample of histology) and HPV DNA testing were performed at approximately 4-month intervals yielding data from over 7,900 clinic visits...
June 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28500655/discovery-and-validation-of-candidate-host-dna-methylation-markers-for-detection-of-cervical-precancer-and-cancer
#13
Megan A Clarke, Patricia Luhn, Julia C Gage, Clara Bodelon, S Terence Dunn, Joan Walker, Rosemary Zuna, Stephen Hewitt, J Keith Killian, Liying Yan, Andrew Miller, Mark Schiffman, Nicolas Wentzensen
Human papillomavirus (HPV) testing has been recently introduced as an alternative to cytology for cervical cancer screening. However, since most HPV infections clear without causing clinically relevant lesions, additional triage tests are required to identify women who are at high risk of developing cancer. We performed DNA methylation profiling on formalin-fixed, paraffin-embedded tissue specimens from women with benign HPV16 infection and histologically confirmed cervical intraepithelial neoplasia grade 3, and cancer using a bead-based microarray covering 1,500 CpG sites in over 800 genes...
May 13, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28489874/tafazzin-taz-promotes-the-tumorigenicity-of-cervical-cancer-cells-and-inhibits-apoptosis
#14
Mei Chen, Yuan Zhang, Peng-Sheng Zheng
Tafazzin (TAZ) is often aberrantly expressed in some cancers, including rectal cancer and thyroid neoplasms. However, the function of TAZ in cervical cancer cells remains unknown. This study aims to explore the expression and function of TAZ in cervical cancer cells. Here, we determined the expression of TAZ protein in normal cervical tissue (NC, n = 27), high-grade squamous intraepithelial lesions (HSIL, n = 26) and squamous cervical carcinoma (SCC, n = 41) by immunohistochemistry, the expression of TAZ protein gradually increased from NC to HSIL to SCC...
2017: PloS One
https://www.readbyqxmd.com/read/28488232/triage-for-management-of-cervical-high-grade-squamous-intraepithelial-lesion-patients-with-positive-margin-by-conization-a-retrospective-analysis
#15
Yuya Dou, Xiaodan Zhang, Yang Li, Fenfen Wang, Xing Xie, Xinyu Wang
The objective of this study is to guide a triage for the management of cervical high-grade squamous intraepithelial lesion (HSIL) patients with positive margin by conization. Clinico-pathological data of HSIL patients with positive margin by conization were retrospectively collected from January 2009 to December 2014. All patients underwent secondary conization or hysterectomy within 6 months. The rate of residual lesion was calculated, and the factors associated with residual lesion were analyzed by univariate and multivariate analyses...
June 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28481782/oral-human-papillomavirus-in-women-with-high-grade-cervical-intraepithelial-neoplasia
#16
Linn Woelber, Julia Breuer, Thomas Meyer, Eik Vettorazzi, Katharina Prieske, Inga Bohlmann, Chia-Jung Busch, Ingo Teudt, Oliver Brummer, Volkmar Mueller, Barbara Schmalfeldt, Donata Grimm
OBJECTIVE: This study was designed to investigate the co-prevalence of cervical and oropharyngeal human papillomavirus (HPV) infection in patients with HPV-related high-grade disease of the uterine cervix (high-grade squamous intraepithelial lesion [HSIL]). MATERIALS AND METHODS: In a prospective cohort study, women with abnormal cervical cytology admitted to our colposcopy units received HPV testing of the uterine cervix and the oropharynx via smear. From a subset of patients, oral lavage was collected to compare detection rates of HPV DNA between lavage and swab...
May 5, 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28469316/cervical-cytopathological-changes-among-women-with-vaginal-discharge-attending-teaching-hospital
#17
Magdi M Salih, Fatma Tage El Sir AlHag, Mohammed Ahmed Khalifa, Abdulla H El Nabi
AIMS: To find cytology changes among women attending obstetrics and gynaecology clinic with complaints of vaginal discharges. SETTINGS AND DESIGN: This descriptive hospital-based cytological study was conducted at the outpatient clinic of the obstetrics and gynaecology department. MATERIALS AND METHODS: Two hundred women with complaints of vaginal discharge were selected. Their detailed histories were documented on a special request form. Pap smears were then obtained and sent for cytological examination to the cytopathology department...
April 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28454277/monocyte-derived-dendritic-cells-from-patients-with-cervical-intraepithelial-lesions
#18
Angela Maria Moed Lopes, Márcia Antoniazi Michelin, Eddie Fernando Cândido Murta
Immunotherapy with dendritic cells (DCs) is a great promise for the treatment of neoplasms. However, the obtainment and protocol of differentiation of these cells may depend on extrinsic factors such as the tumor itself. The aim of the present study was to verify the influence of cervical neoplasia on different protocols of differentiation of monocyte-derived DCs resulting in an increased maturation phenotype. A total of 83 women were included in the study. The patients were grouped in low-grade squamous intraepithelial lesion (LSIL) (n=30), high-grade squamous intraepithelial lesion (HSIL) (n=22), cervical cancer (n=10) and healthy patients (n=21) groups...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28453530/intracellular-signaling-entropy-can-be-a-biomarker-for-predicting-the-development-of-cervical-intraepithelial-neoplasia
#19
Masakazu Sato, Kei Kawana, Katsuyuki Adachi, Asaha Fujimoto, Mitsuyo Yoshida, Hiroe Nakamura, Haruka Nishida, Tomoko Inoue, Ayumi Taguchi, Juri Ogishima, Satoko Eguchi, Aki Yamashita, Kensuke Tomio, Osamu Wada-Hiraike, Katsutoshi Oda, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fujii
While the mortality rates for cervical cancer have been drastically reduced after the introduction of the Pap smear test, it still is one of the leading causes of death in women worldwide. Additionally, studies that appropriately evaluate the risk of developing cervical lesions are needed. Therefore, we investigated whether intracellular signaling entropy, which is measured with microarray data, could be useful for predicting the risks of developing cervical lesions. We used three datasets, GSE63514 (histology), GSE27678 (cytology) and GSE75132 (cytology, a prospective study)...
2017: PloS One
https://www.readbyqxmd.com/read/28445270/pooled-analysis-on-the-necessity-of-random-4-quadrant-cervical-biopsies-and-endocervical-curettage-in-women-with-positive-screening-but-negative-colposcopy
#20
Shang-Ying Hu, Wen-Hua Zhang, Shu-Min Li, Nan Li, Man-Ni Huang, Qin-Jing Pan, Xun Zhang, Ying Han, Fang-Hui Zhao, Wen Chen, You-Lin Qiao
Controversy remains over whether random cervical biopsies and endocervical curettage (ECC) should be used in women with positive screening but negative colposcopy. Our paper aims to determine the indications for random biopsies and ECC among these screened positive women.Three thousand two hundred thirteen women with any positive screening test result but negative colposcopy, who received random 4-quadrant biopsies, were pooled from 17 population-based cervical cancer screening studies done in China from 1999 to 2008...
April 2017: Medicine (Baltimore)
keyword
keyword
45567
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"