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https://www.readbyqxmd.com/read/29794612/delayed-onset-of-persistent-discogenic-axial-and-radiating-pain-following-a-single-level-lumbar-intervertebral-disc-injury-in-mice
#1
Magali Millecamps, Laura S Stone
Low back pain is associated with both axial discomfort and radiating leg pain. While intervertebral discs are suspected as the source of pain in some individuals, the relationship between disc degeneration and back pain remains controversial. The goals of this study were to investigate the long-term impact of L4/L5 disc puncture on disc degeneration and the subsequent emergence, persistence and underlying mechanisms of axial and radiating LBP in mice. L4-L5 discs were punctured on the ventral aspect with a 30 gauge needle in 3-month old female CD1 mice and the development of behavioral signs of axial discomfort (tail suspension and grip force), radiating hypersensitivity (von Frey and acetone), and motor impairment (rotarod) were monitored...
May 22, 2018: Pain
https://www.readbyqxmd.com/read/29745371/microrna-194-inhibits-lipopolysaccharide-induced-inflammatory-response-in-nucleus-pulposus-cells-of-the-intervertebral-disc-by-targeting-tnf-receptor-associated-factor-6-traf6
#2
Lili Kong, Mingxiao Sun, Zhaofu Jiang, Liming Li, Bing Lu
BACKGROUND The dramatic increase of intervertebral disc degeneration (IDD) is considered to be a major cause of discogenic low back pain. The current study focused on the regulatory function of microRNA-194 (miR-194) on lipopolysaccharide (LPS)-induced inflammatory response in nucleus pulposus (NP) cells. MATERIAL AND METHODS LPS was used to treat NP cells to induce inflammatory responses. MiRNA and gene expression were detected by quantitative PCR. Proteins and protein expression levels were detected by Western blot and ELISA kit...
May 10, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29732431/platelet-rich-plasma-injections-an-emerging-therapy-for-chronic-discogenic-low-back-pain
#3
REVIEW
Suja Mohammed, James Yu
Autologous platelet-rich plasma (PRP) injections have been investigated in recent years as an emerging therapy for various musculoskeletal conditions, including lumbar degenerative disc disease. Although PRP has received increasing attention from medical science experts, comprehensive clinical reports of its efficacy are limited to those treating knee osteoarthritis and epicondylitis. Use of PRP is gaining popularity in the area of degenerative disc disease, but there is a clear need for reliable clinical evidence of its applications and effectiveness...
March 2018: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29708266/nerves-and-blood-vessels-in-degenerated-intervertebral-discs-are-confined-to-physically-disrupted-tissue
#4
Polly Lama, Christine L Le Maitre, Ian J Harding, Patricia Dolan, Michael A Adams
Nerves and blood vessels are found in the peripheral annulus and endplates of healthy adult intervertebral discs. Degenerative changes can allow these vessels to grow inwards and become associated with discogenic pain, but it is not yet clear how far, and why, they grow in. Previously we have shown that physical disruption of the disc matrix, which is a defining feature of disc degeneration, creates free surfaces which lose proteoglycans and water, and so become physically and chemically conducive to cell migration...
July 2018: Journal of Anatomy
https://www.readbyqxmd.com/read/29668635/effect-of-intradiscal-pulsed-radiofrequency-on-refractory-chronic-discogenic-neck-pain-a-case-report
#5
So Young Kwak, Min Cheol Chang
RATIONALE: Despite medication, exercise, and medical intervention, many patients complain of persistent discogenic neck pain. To manage discogenic neck pain, we performed intradiscal pulsed radiofrequency (PRF) stimulation in a patient with chronic discogenic neck pain refractory to oral medication and epidural steroid injection. PATIENT CONCERNS: A 26-year-old man presented with a numeric rating scale (NRS) score of 7 for chronic neck pain. His pain was worse when the neck was held in one position for a prolonged period...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29565943/an-update-of-the-systematic-appraisal-of-the-accuracy-and-utility-of-discography-in-chronic-spinal-pain
#6
Laxmaiah Manchikanti, Amol Soin, Ramsin M Benyamin, Vijay Singh, Frank Je Falco, Aaron K Calodney, Vahid Grami, Joshua A Hirsch
BACKGROUND: The intervertebral disc has been implicated as a major cause of chronic spinal pain based on clinical, basic science, and epidemiological research. There is, however, a lack of consensus regarding the diagnosis and treatment of intervertebral disc disorders. Based on controlled evaluations, lumbar intervertebral discs have been shown to be the source of chronic back pain without disc herniation in 26% to 39% of patients, and in 16% to 53% of patients with pain in the cervical spine...
March 2018: Pain Physician
https://www.readbyqxmd.com/read/29508435/macrophage-derived-inflammatory-cytokines-regulate-growth-factors-and-pain-related-molecules-in-mice-with-intervertebral-disc-injury
#7
Masayuki Miyagi, Kentaro Uchida, Shotaro Takano, Hisako Fujimaki, Jun Aikawa, Hiroyuki Sekiguchi, Naoshige Nagura, Seiji Ohtori, Gen Inoue, Masashi Takaso
Upregulation of inflammatory cytokines and various growth factors is a significant contributor to discogenic low back pain. The aim of this study was to investigate possible regulation of pain-related molecules by macrophages and the role of macrophage-derived molecules in injured intervertebral disc (IVD)s. C57BL/6J mice were used in this study. We characterized the expression profiles of genes for tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, nerve growth factor (NGF), and vascular endothelial growth factor (VEGF) in both intact and injured IVDs...
March 6, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29469163/a-method-for-characterising-human-intervertebral-disc-glycosaminoglycan-disaccharides-using-liquid-chromatography-mass-spectrometry-with-multiple-reaction-monitoring
#8
X Liu, D Krishnamoorthy, L Lin, P Xue, F Zhang, L Chi, R J Linhardt, J C Iatridis
Intervertebral disc (IVD) degeneration results in the depletion of proteoglycans and glycosaminoglycans (GAGs), which can lead to structural and mechanical loss of IVD function, ingrowth of nociceptive nerve fibres and eventually discogenic pain. Specific GAG types as well as their disaccharide patterns can be predictive of disease and degeneration in several tissues but have not been comprehensively studied within the IVD. A highly sensitive mass spectrometry based technique with multiple reaction monitoring (MRM) was used to provide characterisation of chondroitin sulphate (CS), hyaluronic acid (HA), heparan sulphate (HS) and their disaccharide sulphation patterns across different anatomical regions of human IVDs...
February 22, 2018: European Cells & Materials
https://www.readbyqxmd.com/read/29386913/altered-low-frequency-oscillation-amplitude-of-resting-state-fmri-in-patients-with-discogenic-low-back-and-leg-pain
#9
Fuqing Zhou, Lili Gu, Shunda Hong, Jiaqi Liu, Jian Jiang, Muhua Huang, Yong Zhang, Honghan Gong
Objective: The aim of this study was to explore the amplitude of intrinsic low-frequency oscillations (LFOs) in patients with discogenic low-back and leg pain (LBLP). Participants and methods: We obtained and compared the LFO amplitude from 25 right-handed discogenic LBLP patients (13 males; mean age 55.16±1.83 years) and 27 well-matched healthy controls (15 males; mean age 52.96±1.63 years). The LFO amplitude was examined using the voxel-wise amplitude of low-frequency fluctuations (ALFFs), and partial correlation analysis was performed to determine the relationship between the regions with altered ALFF values and clinical parameters in discogenic LBLP patients...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29381927/comparison-of-coblation-annuloplasty-and-radiofrequency-thermocoagulation-for-treatment-of-lumbar-discogenic-pain
#10
Dongguang Sun, Quancheng Li, Yuanzhang Tang, Weiyi Gong, Liangliang He, Zhi Dou, Jiaxiang Ni
This study aimed to compare the effectiveness and safety of coblation annuloplasty and radiofrequency thermocoagulation for lumbar discogenic pain.Patients who suffered from lumbar discogenic pain and underwent coblation annuloplasty and radiofrequency thermocoagulation surgery were included. A questionnaire, including the visual analo scale (VAS), MacNab criteria, pain relief rate, and any complications due to surgery, was completed by the patients with the help of a trained volunteer who was blinded to the study...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29376974/-rehabilitation-of-the-patients-presenting-with-the-operated-spine-syndrome-during-the-complicated-postoperative-period-after-discectomy
#11
REVIEW
A E Gorelikov, E A Melnikova, A N Razumov, M A Rassulova, I M Rud
This article presents an analytical review of the literature concerning the problem of rehabilitation of the patients following the surgical treatment of hernias of intervertebral disks. The relevance of this problem and the importance of the related research activities in the context of neurorehabilitation are beyond any doubt. Despite the obvious progress in the modernization of the methods and technologies for medical rehabilitation, the number of re-operations in connection with the recurrences of herniated discs remains too high and the overall success thus far achieved in this field falls short of expectations...
December 5, 2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29203308/magnetic-resonance-imaging-undetectable-epiduroscopic-hotspot-in-chronic-diskogenic-back-pain-does-sinuvertebral-neuropathy-actually-exist
#12
Sung Ho Choi, Nitin Adsul, Hyeun Sung Kim, Jee-Soo Jang, Il-Tae Jang, Seong-Hoon Oh
BACKGROUND: The causes of chronic diskogenic back pain have not yet been clearly identified. Neural ingrowth around the annulus is widely considered to be one of the possible cause. However, neuropathy around the annulus has yet to be observed visually. We report a case of a hotspot that was observed in an epiduroscopic view, but not in imaging findings. CASE DESCRIPTION: A 46-year-old woman was admitted with pain in the back, left buttock, and posterior thigh for 2 years...
February 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29176485/defining-the-ideal-lumbar-total-disc-replacement-patient-and-standard-of-care
#13
Matthew Gornet, Glenn Buttermann, Richard Guyer, James Yue, Nicole Ferko, Sarah Hollmann
: Lumbar total disc replacement, now in use since 2004, was determined by the panel to be a standard of care for the treatment of symptomatic single-level lumbar degenerative disc disease in the active patient subpopulation as outlined by the investigational device exemption study criteria. The large body of evidence supporting this statement, including surgeons' experiences, was presented and discussed. Consensus statements focusing on decision-making criteria reflected that efficacy, long-term safety, clinical outcomes with validated measures, and cost-effectiveness should form the basis of decision-making by payers...
December 15, 2017: Spine
https://www.readbyqxmd.com/read/29150945/development-of-an-in-vivo-mouse-model-of-discogenic-low-back-pain
#14
Changgui Shi, Vaskar Das, Xin Li, Ranjan Kc, Sujun Qiu, InSug O-Sullivan, Richard L Ripper, Jeffrey S Kroin, Fackson Mwale, Atiyayein A Wallace, Bingqian Zhu, Lan Zhao, Andre J van Wijnen, Mingliang Ji, Jun Lu, Gina Votta-Velis, Wen Yuan, Hee-Jeong Im
Discogenic Low back pain (DLBP) is extremely common and costly. Effective treatments are lacking due to DLBP's unknown pathogenesis. Currently, there are no in vivo mouse models of DLBP, which restricts research in this field. The aim of this study was to establish a reliable DLBP model in mouse that captures the pathological changes in the disc and allows longitudinal pain testing. The model was generated by puncturing the mouse lumbar discs (L4/5, L5/6, and L6/S1) and removing the nucleus pulposus using a microscalpel under the microscope...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29149159/in-errata-cost-utility-analysis-of-lumbar-interlaminar-epidural-injections-in-the-treatment-of-lumbar-disc-herniation-central-spinal-stenosis-and-axial-or-discogenic-low-back-pain
#15
https://www.readbyqxmd.com/read/29141662/safety-and-tolerability-of-intradiscal-implantation-of-combined-autologous-adipose-derived-mesenchymal-stem-cells-and-hyaluronic-acid-in-patients-with-chronic-discogenic-low-back-pain-1-year-follow-up-of-a-phase-i-study
#16
Hemant Kumar, Doo-Hoe Ha, Eun-Jong Lee, Jun Hee Park, Jeong Hyun Shim, Tae-Keun Ahn, Kyoung-Tae Kim, Alexander E Ropper, Seil Sohn, Chung-Hun Kim, Devang Kashyap Thakor, Soo-Hong Lee, In-Bo Han
BACKGROUND: Adipose tissue-derived mesenchymal stem cells (AT-MSCs) offer potential as a therapeutic option for chronic discogenic low back pain (LBP) because of their immunomodulatory functions and capacity for cartilage differentiation. The goal of this study was to assess the safety and tolerability of a single intradiscal implantation of combined AT-MSCs and hyaluronic acid (HA) derivative in patients with chronic discogenic LBP. METHODS: We performed a single-arm phase I clinical trial with a 12-month follow-up and enrolled 10 eligible chronic LBP patients...
November 15, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29128087/-platelet-rich-plasma-prp-and-disc-lesions-a-review-of-the-literature
#17
REVIEW
L Charneux, C Demoulin, M Vanderthomment, M Tomasella, M-A Ferrara, S Grosdent, S Bethlen, R Fontaine, P Gillet, T Racaru, J-F Kaux
The spine has been the subject of extensive clinical research since it is the source of many painful complaints. However, there is little scientific evidence concerning the therapeutic proposals. During the course of life, the intervertebral disc degenerates, which over time diminishes its damping capacity and facilitates the expulsion of the nucleus pulposus through the annulus fibrosus. The degeneration of the intervertebral disc (DDI) is the origin of some back pain and various specific treatments have been developed...
December 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29104343/low-intensity-pulsed-ultrasound-lipus-for-the-treatment-of-intervertebral-disc-degeneration
#18
Devante Horne, Peter Jones, Vasant Salgaonkar, Matt Adams, B Arda Ozilgen, Peter Zahos, Xinyan Tang, Ellen Liebenburg, Dezba Coughlin, Jeffrey Lotz, Chris Diederich
Discogenic back pain presents a major public health issue, with current therapeutic interventions limited to short-term symptom relief without providing regenerative remedies for diseased intervertebral discs (IVD). Many of these interventions are invasive and can diminish the biomechanical integrity of the IVDs. Low intensity pulsed ultrasound (LIPUS) is a potential treatment option that is both non-invasive and regenerative. LIPUS has been shown to be a clinically effective method for the enhancement of wound and fracture healing...
January 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/29016955/is-a-history-of-severe-episodic-low-back-pain-an-indicator-of-a-discogenic-etiology
#19
David Levi, Diana Carnahan, Scott Horn, Josh Levin
Objective: To determine if a history of severe episodic low back pain (LBP) correlates with positive discography. Methods: A retrospective chart review identified patients undergoing discography from January 2012 through February 2016. The review determined if the patient's LBP began or continued with severe disabling episodes (lasting a minimum of two days). A gradual onset or initiating event with continuous symptoms was considered a nonepisodic history. Patients were excluded for unclear record, workers' compensation, litigation, prior lumbar surgery, radiologic instability, or indeterminate discography...
June 17, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28970490/mast-cell-intervertebral-disc-cell-interactions-regulate-inflammation-catabolism-and-angiogenesis-in-discogenic-back-pain
#20
Matthew G Wiet, Andrew Piscioneri, Safdar N Khan, Megan N Ballinger, Judith A Hoyland, Devina Purmessur
Low back pain (LBP) is a widespread debilitating disorder of significant socio-economic importance and intervertebral disc (IVD) degeneration has been implicated in its pathogenesis. Despite its high prevalence the underlying causes of LBP and IVD degeneration are not well understood. Recent work in musculoskeletal degenerative diseases such as osteoarthritis have revealed a critical role for immune cells, specifically mast cells in their pathophysiology, eluding to a potential role for these cells in the pathogenesis of IVD degeneration...
October 2, 2017: Scientific Reports
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