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https://www.readbyqxmd.com/read/29684633/efficacy-of-a-carrageenan-gel-against-transmission-of-cervical-hpv-catch-interim-analysis-of-a-randomized-double-blind-placebo-controlled-phase-2b-trial
#1
Sindy Magnan, Joseph E Tota, Mariam El-Zein, Ann N Burchell, John T Schiller, Alex Ferenczy, Pierre-Paul Tellier, François Coutlée, Eduardo L Franco
OBJECTIVE: We evaluated the efficacy of a carrageenan-based lubricant gel in reducing the risk of genital human papillomavirus (HPV) infections in women. METHODS: We conducted a planned interim analysis of a randomized, double-blind, placebo-controlled, phase 2B trial. Women aged 18 years and older were randomly assigned (1:1) to a carrageenan-based or a placebo gel to be self-applied every other day for the first month and prior to and following each intercourse during follow-up...
April 20, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29684049/clinical-factors-associated-with-early-progression-and-grade-3-4-toxicity-in-patients-with-advanced-non-small-cell-lung-cancers-treated-with-nivolumab
#2
Coraline Dumenil, Marie-Ange Massiani, Jennifer Dumoulin, Violaine Giraud, Sylvie Labrune, Thierry Chinet, Etienne Giroux Leprieur
INTRODUCTION: The prognosis of advanced non-small-cell lung cancer (NSCLC) has been improved by development of immune checkpoint inhibitors (ICIs) such as nivolumab for second-line treatment. As phase III trials include only selected patients, we here investigated the clinical factors associated with efficacy and safety of nivolumab in 'real life' patients with advanced NSCLC. METHODS: Clinical and histological characteristics, therapies and survival data of all consecutive patients with advanced NSCLC included prospectively and treated by nivolumab in two French academic hospitals between February 2015 and December 2016 were examined...
2018: PloS One
https://www.readbyqxmd.com/read/29683855/a-week-48-randomized-phase-3-trial-of-darunavir-cobicistat-emtricitabine-tenofovir-alafenamide-in-treatment-na%C3%A3-ve-hiv-1-patients
#3
Joseph J Eron, Chloe Orkin, Joel Gallant, Jean-Michel Molina, Eugenia Negredo, Andrea Antinori, Anthony Mills, Jacques Reynes, Erika Van Landuyt, Erkki Lathouwers, Veerle Hufkens, John Jezorwski, Simon Vanveggel, Magda Opsomer
OBJECTIVES: To investigate efficacy and safety of a single-tablet regimen of darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) 800/150/200/10 mg vs. darunavir/cobicistat plus emtricitabine/tenofovir disoproxyl fumarate (TDF) (control) in antiretroviral-treatment-naïve, HIV-1-infected adults. DESIGN: Phase-3, randomized, active-controlled, double-blind, international, multicenter, noninferiority study (NCT02431247). METHODS: Seven hundred and twenty-five participants were randomized (1 : 1) to D/C/F/TAF (362) or control (363)...
April 19, 2018: AIDS
https://www.readbyqxmd.com/read/29683779/antibiotic-resistance-in-food-animals-in-africa-a-systematic-review-and-meta-analysis
#4
Luria Leslie Founou, Daniel Gyamfi Amoako, Raspail Carrel Founou, Sabiha Yusuf Essack
OBJECTIVES: This study critically reviewed the published literature and performed a meta-analysis to determine the overall burden of antibiotic-resistant bacteria in food animals in Africa. METHODS: English and French published articles indexed in EBSCOhost, PubMed, Web of Science, and African Journals Online were retrieved, with searches being conducted up to August, 2015. Data were pooled and meta-analysis performed using a random-effects model, and the results are described as event rates...
April 23, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29683561/a-study-of-the-potential-interaction-between-bazedoxifene-and-atorvastatin-in-healthy-postmenopausal-women
#5
William McKeand, Susan Baird-Bellaire, James Ermer, Alain Patat
An open-label, 3-period study was conducted in 30 healthy postmenopausal women (mean age, 58.4 years) who received a single oral dose of atorvastatin 20 mg on day 1 (period 1), multiple daily dosing of bazedoxifene 40 mg on days 4-11 (period 2), and coadministration of atorvastatin 20 mg + bazedoxifene 40 mg on day 12 (period 3). Serial blood samples were collected (24 hours after bazedoxifene and 72 hours after atorvastatin) and assayed for bazedoxifene, atorvastatin, and its ortho-hydroxy and para-hydroxy metabolites...
April 23, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29683412/225-intracranial-aneurysms-treated-with-the-low-profile-visualized-intraluminal-support-lvis-stent-a-single-center-retrospective-study
#6
Wei Su, Yisen Zhang, Junfan Chen, Jian Liu, Gary Rajah, Xinjian Yang
Background For the treatment of intracranial aneurysms, the low-profile visualized intraluminal support (LVIS) stent is a new generation of highly visible-braided stent that was recently introduced in China. Here, we report our single-center retrospective experience of safety and efficacy utilizing LVIS for stent-assisted coiling of intracranial aneurysms. Methods We included 218 patients with intracranial aneurysms consecutively treated with LVIS SR stents at our center in this study. Postoperative and follow-up embolization scores, procedural complications, clinical and angiographic findings at mid-term follow-up, as well as recurrence rate, preoperative and follow-up mRS scores were analyzed...
April 23, 2018: Neurological Research
https://www.readbyqxmd.com/read/29683362/immunogenicity-of-biologic-therapies-causes-and-consequences
#7
Wolf-Henning Boehncke, Nicolo Costantino Brembilla
Antibodies or fusion proteins termed biologics allow the targeted therapy of diseases. Many of these agents have proven superior efficacy and safety to conventional therapies, and subsequently revolutionized the management of numerous chronic diseases. Repetitive administration of these protein-based therapeutics to immunocompetent patients elicit immune responses in the form of Anti Drug Antibodies (ADAs), which in turn impact their pharmacological properties and may trigger adverse events. Areas covered: Structural characteristics determining the immunogenicity of biologics are reviewed along with strategies to minimize it...
April 23, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29683314/enantioselective-effects-of-metalaxyl-enantiomers-in-adolescent-rat-metabolic-profiles-using-nmr-based-metabolomics
#8
Jinping Gu, Chenyang Ji, Siqing Yue, Dan Shu, Feng Su, Yinjun Zhang, Yuanyuan Xie, Yi Zhang, Weiping Liu, Meirong Zhao
More than 30% of the registered pesticides are chiral with one or more chiral centers and exist as two or more enantiomers. The frequency of chiral chemicals and their environmental safety has been considered in their risk assessment in recent decades. Despite the fact that metabolic disturbance is an important sensitive molecular initiating event of toxicology effects, the potential mechanisms of how chiral compounds affect metabolism phenotypes in organisms remain unclear. As a typical chiral pesticide, metalaxyl is an acylalanine fungicide with systemic function...
April 23, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29683286/safety-profile-of-chronic-leg-ulcer-biopsy-a-monocentric-retrospective-series-on-866-patients
#9
Carlotta Baraldi, Lidia Sacchelli, Emi Dika, Martina Lambertini, Cosimo Misciali, Tommaso Bianchi, Pier A Fanti
BACKGROUND: Skin biopsy is an important tool for various skin conditions. However, in the case of leg ulcers, some Authors still consider it highly risky and mandatory only in selected cases. METHODS: To evaluate the rate of adverse events after leg ulcers biopsy in 866 consecutive patients referring to our Wound Care Unit in Bologna from January 2008 to December 2016. Two biopsies were performed (from the border and the centre) by the same dermatologist following a standardized structured protocol...
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29683095/azilsartan-and-chlorthalidone-new-powerful-fixed-dose-antihypertensive-combination
#10
Vasiliki Katsi, Eleni Athanasiadi, Costas Tsioufis, Dimitris Tousoulis
Arterial hypertension is a disease that still affects a major part of the population worldwide, and leads to fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. From the CDC statistical analysis, as regarding to United States, 1 of every 3 adults has high blood pressure, and οnly about half (54%) of them have it under control. Furthermore, all that leads to a nation cost about $46 billion each year. Efforts to find new ways to regulate arterial hypertension are therefore imperative...
April 20, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29682796/phase-2a-randomized-double-blind-placebo-controlled-multicenter-parallel-group-study-of-an-h-4-r-antagonist-jnj-39758979-in-adults-with-uncontrolled-asthma
#11
Alexa P Kollmeier, Andrew Greenspan, Xie L Xu, Philip E Silkoff, Elliot Barnathan, Matthew J Loza, Jingzhi Jiang, Bei Zhou, Bin Chen, Robin L Thurmond
BACKGROUND: The effects of H4 R antagonists in preclinical asthma models support the study of antagonists of the H4 R in the treatment of asthma in humans. JNJ-39758979 is a potent and highly-selective oral H4 R antagonist. OBJECTIVE: We sought to evaluate the safety and efficacy of the H4 R-antagonist JNJ-39758979 in adult patients with uncontrolled asthma. METHODS: One hundred and fifteen eligible patients were randomly assigned to JNJ-39758979 300 mg or placebo once daily for 12 weeks in this phase 2a, double-blind, multicenter, placebo-controlled study...
April 23, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29682765/white-privilege-what-s-a-family-therapist-to-do
#12
Gene Combs
Privilege is the freedom to ignore things that other people are forced to confront; dramatic things like being gunned down by a vigilante on the way home from a convenience store or less urban and visible things like having to live on secluded parcels of land that no one else wants. Most family therapists enjoy the freedom not to experience such events. Many of the people who come to us for help don't have that freedom. My intent here is to increase felt awareness of the injustice of institutional racism and to suggest some actions that White family therapists can take to bring forth a more just society in terms of education, housing, access to wealth, and basic safety...
April 22, 2018: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/29682466/video-assisted-thoracoscopic-plasmajet-ablation-for-malignant-pleural-mesothelioma
#13
Periklis Perikleous, Nizar Asadi, Vladimir Anikin
The role of surgery in malignant pleural mesothelioma (MPM) remains debatable; nonetheless the relative advantages of different surgical approaches are frequently reassessed and reconsidered. While extensive operations and longer recovery periods can be justified for a group of carefully selected patients, many will present at an advanced stage of their disease or with associated co-morbidities which will exclude them from selection criteria for radical treatment. For these patients, minimally invasive video-assisted procedures may be considered, for purposes of cytoreduction and/or symptomatic relief...
2018: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29682324/certolizumab-pegol-in-a-heterogeneous-population-of-patients-with-moderate-to-severe-rheumatoid-arthritis
#14
Enrique R Soriano, Analia Dellepiane, Gabriela Salvatierra, Cristian Alejandro Benítez, Rodrigo Garcia Salinas, Carlos Baruzzo
Aim: To determine the efficacy and safety of certolizumab pegol for the treatment of rheumatoid arthritis in a real-world setting. Materials & methods: Patients with moderate-to-severe rheumatoid arthritis who initiated therapy with certolizumab were followed for 12 weeks. Response was assessed with Disease Activity Score of 28 joints, European Ligue Against Rheumatism criteria and Simplified Disease Activity Index. Predictors of response were analyzed with binary logistic regression models...
April 2018: Future Science OA
https://www.readbyqxmd.com/read/29682298/tenofovir-alafenamide-versus-tenofovir-disoproxil-fumarate-is-there-a-true-difference-in-efficacy-and-safety
#15
EDITORIAL
Andrew Hill, Sophie L Hughes, Dzintars Gotham, Anton L Pozniak
Background: Higher plasma tenofovir concentrations are associated with higher risks of renal and bone adverse events. The pharmacokinetic boosters ritonavir (RTV) and cobicistat (COBI) significantly increase plasma area under the curve (AUC) concentrations of tenofovir disoproxil fumarate (TDF), by 25-37%. When combined with RTV or COBI, the dose of tenofovir alafenamide (TAF) is lowered from 25 mg to 10 mg daily, but the TDF dose is maintained at 300 mg daily. Objective: To assess the differences in safety and efficacy between tenofovir alafenamide (TAF) and tenofovir disoproxil fumarate (TDF) in regimens with and without the pharmacokinetic boosters RTV and COBI...
April 1, 2018: Journal of Virus Eradication
https://www.readbyqxmd.com/read/29682272/maintenance-of-fish-health-in-aquaculture-review-of-epidemiological-approaches-for-prevention-and-control-of-infectious-disease-of-fish
#16
REVIEW
Ayalew Assefa, Fufa Abunna
Aquaculture is rapidly growing part of agriculture worldwide. It makes up around 44 percent of total fish production globally. This increased growth of production is achieved despite facing many challenges in the aquaculture environment. Among production limiting challenges, the infectious disease takes the lion share by causing multibillion-dollar loss annually. To reduce the impact of the fish disease, it is necessary to address health constraints based on scientifically proven and recommended ways. This review aims at pointing out some of the best approaches to prevention and control of infectious disease in aquaculture...
2018: Veterinary Medicine International
https://www.readbyqxmd.com/read/29682138/successful-retrograde-recanalization-of-acute-right-dominant-vertebral-artery-occlusion-through-the-left-posterior-communicating-artery-in-a-patient-with-acute-vertebrobasilar-ischemic-stroke
#17
Anton A Khilchuk, Maksim V Agarkov, Sergey V Vlasenko, Sergey G Scherbak, Andrey M Sarana, Svetlana V Lebedeva
Advanced endovascular technology and techniques allow interventional radiologists to utilize novel ways of basilar artery recanalization in the setting of acute ischemic stroke, especially when routine approaches are not eligible. Several authors described nonstandard revascularization techniques in acute ischemic strokes due to basilar and middle cerebral arteries occlusions with full technical and clinical success. In this report, we present retrograde right vertebral artery recanalization using left posterior communicating artery for subsequent anterograde balloon angioplasty and stenting of a right vertebral artery ostium followed by full vertebrobasilar blood flow restoration...
April 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29681629/incidence-of-complications-in-dermatological-surgery-of-melanoma-and-non-melanoma-skin-cancer-in-patients-with-multiple-comorbidity-and-or-antiplatelet-anticoagulants-five-year-experience-in-our-hospital
#18
Lilia Arguello-Guerra, Estefanía Vargas-Chandomid, Jose Manuel Díaz-González, Silvia Méndez-Flores, Ana Ruelas-Villavicencio, Judith Domínguez-Cherit
Introduction: Surgery is performed more frequently now at days, due to the increasing incidence of melanoma and no-melanoma skin cancer. There are different opinions among dermatologic surgeons between to continue or discontinue antithrombotic therapy prior to the procedure, which increases the risk of thromboembolic events. Prophylaxis with oral antibiotics in the postsurgical period is controversial. Objective: To report the safety of surgery without suspending antithrombotic therapy and without oral antibiotic prophylaxis in dermatology surgery of patients with multiple comorbidities and polypharmacy...
2018: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/29681566/off-pump-coronary-artery-bypass-grafting-with-mini-sternotomy-in-the-treatment-of-triple-vessel-coronary-artery-disease
#19
Pixiong Su, Song Gu, Yan Liu, Xitao Zhang, Jun Yan, Xiangguang An, Jie Gao, Yue Xin, Jian Zhou
We have developed off-pump coronary artery bypass approach with lower distal mini-sternotomy (TM-OPCAB) for multivessel coronary revascularization. The aim of this retrospective study is to provide evidence for the feasibility and safety of this technique in the treatment of triple-vessel diseases.Two hundred eighty-eight patients with triple-vessel coronary artery disease who underwent TM-OPCAB or standard off-pump coronary artery bypass surgery (S-OPCAB) were included in this study after propensity-score matching...
April 20, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29681490/safety-and-efficacy-of-delayed-release-dimethyl-fumarate-in-pediatric-patients-with-relapsing-multiple-sclerosis-focus
#20
Raed Alroughani, Rajiv Das, Natasha Penner, Joe Pultz, Catherine Taylor, Satish Eraly
BACKGROUND: No therapies have been formally approved by the Food and Drug Administration for use in pediatric multiple sclerosis, a rare disease. OBJECTIVE: We evaluated the safety, efficacy, and pharmacokinetics of dimethyl fumarate in pediatric patients with multiple sclerosis. METHODS: FOCUS, a phase 2, multicenter study of patients aged 10 to 17 years with relapsing-remitting multiple sclerosis, comprised an eight-week baseline and 24-week treatment period; during treatment, patients received dimethyl fumarate (120 mg twice daily on days one to seven; 240 mg twice a day thereafter)...
March 22, 2018: Pediatric Neurology
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