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https://www.readbyqxmd.com/read/29332192/how-participatory-should-environmental-governance-be-testing-the-applicability-of-the-vroom-yetton-jago-model-in-public-environmental-decision-making
#1
Nikolas Lührs, Nicolas W Jager, Edward Challies, Jens Newig
Public participation is potentially useful to improve public environmental decision-making and management processes. In corporate management, the Vroom-Yetton-Jago normative decision-making model has served as a tool to help managers choose appropriate degrees of subordinate participation for effective decision-making given varying decision-making contexts. But does the model recommend participatory mechanisms that would actually benefit environmental management? This study empirically tests the improved Vroom-Jago version of the model in the public environmental decision-making context...
January 13, 2018: Environmental Management
https://www.readbyqxmd.com/read/29314632/comparison-of-five-specific-assays-for-determination-of-dabigatran-plasma-concentrations-in-patients-enrolled-in-the-start-laboratory-register
#2
M Cini, C Legnani, B Cosmi, S Testa, C Dellanoce, O Paoletti, R Marcucci, D Poli, R Paniccia, V Pengo, A Tripodi, G Palareti
INTRODUCTION: Several specific assays are commercially available to determine dabigatran anticoagulant activity. Aims of this multicenter and multiplatform study were to compare five methods for dabigatran measurement and investigate their performances in the low concentration range. METHODS: Dabigatran levels were analyzed in 295 plasma samples from patients enrolled in the START-Laboratory Register by the following methods using dedicated calibrators and controls: STA-ECA II (Diagnostica Stago), standard and low range Hemoclot Thrombin Inhibitors (Hyphen BioMed), Direct Thrombin Inhibitor Assay (Instrumentation Laboratory), Direct Thrombin Inhibitor Assay (Siemens), Technoclot DTI (Technoclone)...
January 3, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29286407/generic-protocol-for-optimization-of-heterologous-protein-production-using-automated-microbioreactor-technology
#3
Johannes Hemmerich, Lars Freier, Wolfgang Wiechert, Eric von Lieres, Marco Oldiges
A core business in industrial biotechnology using microbial production cell factories is the iterative process of strain engineering and optimization of bioprocess conditions. One important aspect is the improvement of cultivation medium to provide an optimal environment for microbial formation of the product of interest. It is well accepted that the media composition can dramatically influence overall bioprocess performance. Nutrition medium optimization is known to improve recombinant protein production with microbial systems and thus, this is a rewarding step in bioprocess development...
December 15, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29284903/correlation-between-quality-of-life-and-depression-among-persons-suffering-from-psoriasis
#4
Jasmina Mahmutovic, Mufida Zukic, Arzija Pasalic, Suada Brankovic, Amila Jaganjac, Bakir Katana
Introduction: Chronic dermatitis is a major sociomedical issue still being marginalized due to generally accepted view that skin diseases are less of a health problem than is the case with diseases of other organs and organ systems for they are not life-threatening. Measurement of quality of life of persons suffering from psoriasis could become an important factor in assessing the success of treatment and modern aspect of integration of the diseased into the planning of therapeutic procedures, monitoring of their outcomes and improving the quality of treatment...
October 2017: Medical Archives
https://www.readbyqxmd.com/read/29273384/surgical-technique
#5
REVIEW
Marc Guénot, Axel Lebas, Bertrand Devaux, Sophie Colnat-Coulbois, Georg Dorfmuller, Aileen McGonigal, Nicolas Reyns, Vianney Gilard, Stéphane Derrey, Jean-Christophe Sol, Stéphane Clémenceau
In SEEG, as for any surgical procedure, the benefit/risk ratio is a key-point. This implies rigorous clinical practice in terms of indication, information delivered to the patient, and surgical technique. Numerous technical options may be used to achieve this goal. All are valuable, as long as they are executed with rigor and consistency. Intracranial bleeding represents the main risk of the procedure (1-4% of cases). The procedure also carries a risk of infection (0.8%), death (total of 6 reported cases in all the literature, <0...
December 19, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/29239925/the-validity-of-training-endoscopic-sinus-and-skull-base-surgery-techniques-on-the-experimental-head-model
#6
Ranko Mladina, Neven Skitarelić, Cemal Cingi, Lei Chen, Nuray Bayar Muluk
OBJECTIVES: The aim of this study was to better understand the usual learning curve in acquiring endonasal endoscopic sinus and skull base surgery (ESSBS) techniques during the novice training on the lamb's head model. METHODS: Ten novices were asked to perform 10 bilateral dissections on the particular lamb's head each. The dissections were uniform, consisted of 10 well-defined steps, beginning from the simple removal of the inferior turbinate, and ending with more complicated procedures like cerebrospinal fluid leak repair, Draf 3 procedure for the frontal sinus and elevation of the nasal septal flap...
December 12, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29236172/the-society-of-european-robotic-gynaecological-surgery-sergs-pilot-curriculum-for-robot-assisted-gynecological-surgery
#7
Peter Rusch, Rainer Kimmig, Fabrice Lecuru, Jan Persson, Jordi Ponce, Michel Degueldre, René Verheijen
PURPOSE: To set forth experiences in the context of the SERGS Pilot Curriculum-the first standardized educational program for robotic use in gynecological surgery-in terms of feasibility, effectiveness and potential for certification. METHODS: The Society of European Robotic Gynecological Surgery (SERGS) outlined a Pilot Curriculum for standardized education in robot-assisted laparoscopic gynecological surgery. Its feasibility and acceptance were checked in the form of a fellowship pilot program conducted at four European Centers of Excellence for robot-assisted surgery...
December 13, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29233486/cetuximab-combined-with-induction-oxaliplatin-and-capecitabine-followed-by-neoadjuvant-chemoradiation-for-locally-advanced-rectal-cancer-swog-0713
#8
Cynthia Gail Leichman, Shannon L McDonough, Stephen R Smalley, Kevin G Billingsley, Heinz-Josef Lenz, Matthew A Beldner, Aram F Hezel, Mario R Velasco, Katherine A Guthrie, Charles D Blanke, Howard S Hochster
BACKGROUND: Neoadjuvant chemoradiation (NCRT) is standard treatment for locally advanced rectal cancer. Pathologic complete response (pCR) has associated with improved survival. In modern phase III trials of NCRT, pCR ranges from 10% to 20%. Cetuximab improves response in KRAS (KRAS proto-oncogene) wild type (wt) metastatic colorectal cancer. S0713 was designed to assess improvement in pCR with additional use of cetuximab with induction chemotherapy and NCRT for locally advanced, KRAS-wt rectal cancer...
October 24, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29233377/application-of-a-systematic-approach-to-evaluating-psychometric-properties-of-a-cumulative-exit-from-degree-objective-structured-clinical-examination-osce
#9
Ahmed Hesham Sobh, Zubin Austin, Mohamed Izham M I, Mohammad I Diab, Kyle John Wilby
BACKGROUND AND PURPOSE: Objective structured clinical examinations (OSCEs) are considered gold standard performance-based assessments yet comprehensive evaluation data is currently lacking. The objective of this study was to critically evaluate the psychometric properties of a cumulative OSCE for graduating pharmacy students in Qatar for which policies and procedures were adapted from a Canadian context. EDUCATIONAL ACTIVITY AND SETTING: A 10-station OSCE was conducted for graduating students in Qatar...
November 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29221278/mitral-valve-repair-versus-replacement-in-elderly-patients-a-systematic-review-and-meta-analysis
#10
Xiaoke Shang, Rong Lu, Mei Liu, Shuna Xiao, Nianguo Dong
Background: Although mitral valve repair (MVP) is generally accepted as the standard treatment for mitral valve disease, in older patients, there is increasing debate about whether MVP is superior to mitral valve replacement (MVR). We, therefore, performed a meta-analysis to compare MVP vs. MVR in the elderly population. Methods: We systematically searched PubMed, the Cochrane Library, and Scopus up to February 2017 and scrutinized the references of relevant literatures...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29219315/calculation-of-standard-reduction-potentials-of-amino-acid-radicals-and-the-effects-of-water-and-incorporation-into-peptides
#11
David M Close, Peter Wardman
Guanine (Guo) is generally accepted as the most easily-oxidized DNA base when cells are subjected to ionizing radiation; calculations of the standard reduction potential of the guanyl radical, Eo(Guo•+/Guo) are within ~ 0.1 V of experimental values in aqueous solution extrapolated to standard conditions. While a number of experimental studies have shown some amino acid radicals have redox properties at pH 7 which suggest or confirm a capacity for radical 'repair' by electron transfer from the amino acid to Guo•+ (or its deprotonated conjugate), the redox properties of the radicals of other amino acids, including methionine, lysine and cystine, are less well characterized...
December 8, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29207362/alcohol-septal-ablation-for-hypertrophic-obstructive-cardiomyopathy-indications-technical-aspects-and-clinical-outcomes
#12
REVIEW
Marco Spaziano, Fadi J Sawaya, Thierry Lefèvre
Hypertrophic cardiomyopathy is the most common genetically transmitted heart disease. Around two-thirds of patients develop symptoms caused by the dynamic left ventricular outflow tract obstruction, either at rest or during effort. For patients with hypertrophic obstructive cardiomyopathy (HOCM) that remain symptomatic despite optimal medical treatment, septal reduction is a valuable therapeutic strategy. While surgical myomectomy was considered the gold standard until the end of the 1990s, alcohol septal ablation (ASA) has gained rapid popularity and acceptance, especially in Europe...
December 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29201260/retinal-prosthesis-system-for-advanced-retinitis-pigmentosa-a-health-technology-assessment-update
#13
(no author information available yet)
Background: Retinitis pigmentosa is a group of inherited disorders characterized by the degeneration of the photoreceptors in the retina, resulting in progressive vision loss. The Argus II system is designed to restore partial functional vision in patients with profound vision loss from advanced retinitis pigmentosa. At present, it is the only treatment option approved by Health Canada for this patient population. In June 2016, Health Quality Ontario published a health technology assessment of the Argus II retinal prosthesis system for patients with advanced retinitis pigmentosa...
2017: Ontario Health Technology Assessment Series
https://www.readbyqxmd.com/read/29186185/cost-effectiveness-of-different-strategies-for-diagnosis-of-uncomplicated-urinary-tract-infections-in-women-presenting-in-primary-care
#14
Judith E Bosmans, Veerle M H Coupé, Bart J Knottnerus, Suzanne E Geerlings, Eric P Moll van Charante, Gerben Ter Riet
BACKGROUND: Uncomplicated Urinary Tract Infections (UTIs) are common in primary care resulting in substantial costs. Since antimicrobial resistance against antibiotics for UTIs is rising, accurate diagnosis is needed in settings with low rates of multidrug-resistant bacteria. OBJECTIVE: To compare the cost-effectiveness of different strategies to diagnose UTIs in women who contacted their general practitioner (GP) with painful and/or frequent micturition between 2006 and 2008 in and around Amsterdam, The Netherlands...
2017: PloS One
https://www.readbyqxmd.com/read/29175541/a-randomized-comparative-study-evaluating-various-cough-stress-tests-and-24-hour-pad-test-with-urodynamics
#15
Joseph W Henderson, Sarah M Kane, Jeffrey M Mangel, Elias G Kikano, Jorge A Garibay, Robert R Pollard, Sangeeta T Mahajan, Sara M Debanne, Adonis K Hijaz
PURPOSE: The cough stress test (CST) is a common and accepted tool to evaluate stress urinary incontinence but there is no agreement on how the test should be conducted. We assessed the diagnostic ability of different CSTs performed varying patient's position and bladder volumes using urodynamic stress urinary incontinence (USI) as the gold standard. The 24-hour pad test was also evaluated. MATERIALS AND METHODS: Women presenting to specialty outpatient clinics with complaints of urinary incontinence and recommended to undergo urodynamic testing were recruited...
November 23, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29158354/confirmatory-tests-for-the-diagnosis-of-primary-aldosteronism-a-prospective-diagnostic-accuracy-study
#16
Ying Song, Shumin Yang, Wenwen He, Jinbo Hu, Qingfeng Cheng, Yue Wang, Ting Luo, Linqiang Ma, Qianna Zhen, Suhua Zhang, Mei Mei, Zhihong Wang, Hua Qing, Dennis Bruemmer, Bin Peng, Qifu Li
The diagnosis of primary aldosteronism typically requires at least one confirmatory test. The fludrocortisone suppression test is generally accepted as a reliable confirmatory test, but it is cumbersome. Evidence from accuracy studies of the saline infusion test (SIT) and the captopril challenge test (CCT) has provided conflicting results. This prospective study aimed to evaluate the diagnostic accuracy of the SIT and CCT using fludrocortisone suppression test as the reference standard. One hundred thirty-five patients diagnosed with primary aldosteronism and 101 patients diagnosed with essential hypertension who completed the 3 confirmatory tests were included for the diagnostic accuracy analysis...
January 2018: Hypertension
https://www.readbyqxmd.com/read/29149813/structural-analysis-of-cd59-of-chinese-tree-shrew-a-new-reference-molecule-for-human-immune-system-specific-cd59-drug-discovery
#17
Subhamay Panda, Leena Kumari, Santamay Panda
BACKGROUND: Chinese tree shrews (Tupaia belangeri chinensis) bear several characteristics that are considered to be very crucial for utilizing in animal experimental models in biomedical research. Subsequent to the identification of key aspects and signaling pathways in nervous and immune systems, it is revealed that tree shrews acquires shared common as well as unique characteristics, and hence offers a genetic basis for employing this animal as a prospective model for biomedical research...
November 17, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29141516/how-to-assess-communication-skills-development-of-the-rating-scale-comon-check
#18
K Radziej, J Loechner, C Engerer, M Niglio de Figueiredo, J Freund, H Sattel, C Bachmann, P O Berberat, A Dinkel, A Wuensch
BACKGROUND: Good communication is a core competency for all physicians. Thus, medical students require adequate preparation in communication skills. For research purposes, as well as for evaluation in teaching, there is a clear need for reliable assessment tools. We analyzed the shortcomings of existing instruments and saw a need for a new rating scale. The aim of this publication is to describe the development process for, and evaluation of, a new rating scale. METHODS: First, we developed the rating scale in 10 steps...
2017: Medical Education Online
https://www.readbyqxmd.com/read/29140141/short-clinical-examination-for-temporomandibular-symptoms-in-general-practice
#19
Christina Mejersjö, Ove Bertilsson, Karin Bäck
OBJECTIVE: The aims of the study are to assess the reliability of the short clinical examination, and to compare the information gained with a well-known and validated examination, the diagnostic criteria for temporomandibular disorders (DC/TMD). MATERIALS AND METHODS: The study comprises 52 consecutive, newly referred patients at their first visit and examination to an Orofacial Pain and TMD Clinic, 15 years and older, mean age 44 years. The patients first answered three screening questions for reported symptoms...
November 15, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29127450/standardisation-of-defined-approaches-for-skin-sensitisation-testing-to-support-regulatory-use-and-international-adoption-position-of-the-international-cooperation-on-alternative-test-methods
#20
S Casati, K Aschberger, J Barroso, W Casey, I Delgado, T S Kim, N Kleinstreuer, H Kojima, J K Lee, A Lowit, H K Park, M J Régimbald-Krnel, J Strickland, M Whelan, Y Yang, Valérie Zuang
Skin sensitisation is the regulatory endpoint that has been at the centre of concerted efforts to replace animal testing in recent years, as demonstrated by the Organisation for Economic Co-operation and Development (OECD) adoption of five non-animal methods addressing mechanisms under the first three key events of the skin sensitisation adverse outcome pathway. Nevertheless, the currently adopted methods, when used in isolation, are not sufficient to fulfil regulatory requirements on the skin sensitisation potential and potency of chemicals comparable to that provided by the regulatory animal tests...
November 10, 2017: Archives of Toxicology
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