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https://www.readbyqxmd.com/read/29149813/structural-analysis-of-cd59-of-chinese-tree-shrew-a-new-reference-molecule-for-human-immune-system-specific-cd59-drug-discovery
#1
Subhamay Panda, Leena Kumari, Santamay Panda
BACKGROUND: Chinese tree shrews (Tupaia belangeri chinensis) bear several characteristics that are considered to be very crucial for utilizing in animal experimental models in biomedical research. Subsequent to the identification of key aspects and signaling pathways in nervous and immune systems, it is revealed that tree shrews acquires shared common as well as unique characteristics, and hence offers a genetic basis for employing this animal as a prospective model for biomedical research...
November 17, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29141516/how-to-assess-communication-skills-development-of-the-rating-scale-comon-check
#2
K Radziej, J Loechner, C Engerer, M Niglio de Figueiredo, J Freund, H Sattel, C Bachmann, P O Berberat, A Dinkel, A Wuensch
BACKGROUND: Good communication is a core competency for all physicians. Thus, medical students require adequate preparation in communication skills. For research purposes, as well as for evaluation in teaching, there is a clear need for reliable assessment tools. We analyzed the shortcomings of existing instruments and saw a need for a new rating scale. The aim of this publication is to describe the development process for, and evaluation of, a new rating scale. METHODS: First, we developed the rating scale in 10 steps...
2017: Medical Education Online
https://www.readbyqxmd.com/read/29140141/short-clinical-examination-for-temporomandibular-symptoms-in-general-practice
#3
Christina Mejersjö, Ove Bertilsson, Karin Bäck
OBJECTIVE: The aims of the study are to assess the reliability of the short clinical examination, and to compare the information gained with a well-known and validated examination, the diagnostic criteria for temporomandibular disorders (DC/TMD). MATERIALS AND METHODS: The study comprises 52 consecutive, newly referred patients at their first visit and examination to an Orofacial Pain and TMD Clinic, 15 years and older, mean age 44 years. The patients first answered three screening questions for reported symptoms...
November 15, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29127450/standardisation-of-defined-approaches-for-skin-sensitisation-testing-to-support-regulatory-use-and-international-adoption-position-of-the-international-cooperation-on-alternative-test-methods
#4
S Casati, K Aschberger, J Barroso, W Casey, I Delgado, T S Kim, N Kleinstreuer, H Kojima, J K Lee, A Lowit, H K Park, M J Régimbald-Krnel, J Strickland, M Whelan, Y Yang, Valérie Zuang
Skin sensitisation is the regulatory endpoint that has been at the centre of concerted efforts to replace animal testing in recent years, as demonstrated by the Organisation for Economic Co-operation and Development (OECD) adoption of five non-animal methods addressing mechanisms under the first three key events of the skin sensitisation adverse outcome pathway. Nevertheless, the currently adopted methods, when used in isolation, are not sufficient to fulfil regulatory requirements on the skin sensitisation potential and potency of chemicals comparable to that provided by the regulatory animal tests...
November 10, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29119232/histopathological-markers-of-treatment-response-and-recurrence-risk-in-ovarian-cancers-and-borderline-tumors
#5
REVIEW
S Avril
Histopathology plays an important role in defining response to treatment for different tumor types. Histopathologic response criteria are currently used as reference standard in various types of cancer, including breast cancer, gastroesophageal cancer, and bone tumors. Since there were no generally accepted response criteria established for ovarian cancer, a systematic analysis of various features of tumor regression was performed. Patient survival served as the reference standard to validate the histopathologic features of tumor regression...
November 8, 2017: Der Pathologe
https://www.readbyqxmd.com/read/29099874/performance-verification-of-the-new-fully-automated-aquios-flow-cytometer-panleucogate-plg-platform-for-cd4-t-lymphocyte-enumeration-in-south-africa
#6
Lindi-Marie Coetzee, Deborah K Glencross
BACKGROUND: The National Health Laboratory Service (NHLS) offers wide-scale CD4 testing through a network of laboratories in South Africa. A new "load and go" cytometer (Aquios CL, Beckman Coulter), developed with a PLG protocol, was validated against the predicate PLG method on the Beckman Coulter FC500 MPL/CellMek platform. METHODS: Remnant routine EDTA blood CD4 reference results were compared to results from two Aquios/PLG instruments (n = 205) and a further n = 1885 samples tested to assess daily testing capacity...
2017: PloS One
https://www.readbyqxmd.com/read/29098701/instruments-to-assess-patient-comfort-during-hospitalization-a-psychometric-review
#7
REVIEW
Sonia Lorente, Josep-Maria Losilla, Jaume Vives
AIM: To analyse the psychometric properties and the utility of instruments used to measure patient comfort, physical, social, psychospiritual and/or environmental, during hospitalization. BACKGROUND: There are no systematic reviews nor psychometric reviews of instruments used to measure comfort, which is considered an indicator of quality in health care associated with quicker discharges, increased patient satisfaction and better cost-benefit ratios for the institution...
November 3, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29098306/-differentiated-surgical-approach-for-adenocarcinoma-of-the-gastroesophageal-junction
#8
REVIEW
W Schröder, R Lambertz, R van Hillegesberger, C Bruns
For adenocarcinoma of the gastroesophageal junction (GEJ) the classification of Siewert with its three subtypes is well established as a practical approach to surgical treatment. Transthoracic esophagectomy with gastric tube formation is generally accepted as the surgical standard for adenocarcinoma of the distal esophagus (GEJ type I). Intrathoracic esophagogastrostomy has become the most frequently used anastomotic technique (Ivor Lewis esophagectomy). Both the abdominal and thoracic part can be safely performed with a minimally invasive access...
November 2, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29070062/microbial-biodiversity-assessment-of-the-european-space-agency-s-exomars-2016-mission
#9
Kaisa Koskinen, Petra Rettberg, Rüdiger Pukall, Anna Auerbach, Lisa Wink, Simon Barczyk, Alexandra Perras, Alexander Mahnert, Diana Margheritis, Gerhard Kminek, Christine Moissl-Eichinger
BACKGROUND: The ExoMars 2016 mission, consisting of the Trace Gas Orbiter and the Schiaparelli lander, was launched on March 14 2016 from Baikonur, Kazakhstan and reached its destination in October 2016. The Schiaparelli lander was subject to strict requirements for microbial cleanliness according to the obligatory planetary protection policy. To reach the required cleanliness, the ExoMars 2016 flight hardware was assembled in a newly built, biocontrolled cleanroom complex at Thales Alenia Space in Turin, Italy...
October 25, 2017: Microbiome
https://www.readbyqxmd.com/read/29062455/laparoscopic-pyloroplasty-for-perforated-peptic-ulcer
#10
Edvard Grišin, Saulius Mikalauskas, Tomas Poškus, Valdemaras Jotautas, Kęstutis Strupas
Peptic ulcer is a common disease affecting millions of people every year. Despite improved understanding and treatment of the disease, the number of patients admitted with duodenal peptic ulcer perforation has not decreased. Deaths from peptic ulcer disease overcome other common emergency situations. Laparoscopic repair of the perforated peptic ulcer (PPU) is the gold standard approach for simple perforation. However, in patients with large perforated chronic ulcers laparotomy with pyloroplasty is the standard treatment...
September 2017: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/29030927/suitability-of-the-forearm-for-non-invasive-blood-pressure-measurement-in-children
#11
David Greaney, Solmaz Nakhjavani, Fiona Desmond, Mark Tormey, Ian Dawkins, Brendan O'Hare
BACKGROUND: Measurement of forearm blood pressure (BP) in pediatric patients during general anesthesia is periodically employed despite a lack of evidence for this practice. Upper arm BP measurement may be impossible to perform for either patient or surgical reasons, and the forearm has theoretical benefits over the lower leg when an alternate site is required. We hypothesize that forearm BP measurement provides an accurate and reliable alternative to the upper arm. Published adult data do not support this hypothesis, and the little pediatric data published contain methodological shortcomings...
November 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28991844/criterion-based-assessment-in-a-norm-based-world-how-can-we-move-past-grades
#12
Anne G Pereira, Majka Woods, Andrew P J Olson, Suzanne van den Hoogenhof, Briar L Duffy, Robert Englander
In the United States, the medical education community has begun a shift from the Flexnerian time-based model to a competency-based medical education model. The graduate medical education (GME) community is substantially farther along in this transition than is the undergraduate medical education (UME) community.GME has largely adopted the use of competencies and their attendant milestones and increasingly is employing the framework of entrustable professional activities (EPAs) to assess trainee competence. The UME community faces several challenges to successfully navigating a similar transition...
October 3, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28982187/assessing-climate-change-robustness-of-protected-area-management-plans-the-case-of-germany
#13
Juliane Geyer, Stefan Kreft, Florian Jeltsch, Pierre L Ibisch
Protected areas are arguably the most important instrument of biodiversity conservation. To keep them fit under climate change, their management needs to be adapted to address related direct and indirect changes. In our study we focus on the adaptation of conservation management planning, evaluating management plans of 60 protected areas throughout Germany with regard to their climate change-robustness. First, climate change-robust conservation management was defined using 11 principles and 44 criteria, which followed an approach similar to sustainability standards...
2017: PloS One
https://www.readbyqxmd.com/read/28979769/single-incision-laparoscopic-surgery-in-gynecologic-surgery-a-single-institutional-experience-from-saudi-arabia
#14
Kareemah Salamah, Mohammed Abuzaid, Ahmed Abu-Zaid
Background: Laparoscopy is rapidly replacing laparotomy in the field of gynecologic surgery. Generally, there are limited data concerning the utility of single-incision laparoscopic surgery (SILS) in gynecologic surgery. Specifically, in Saudi Arabia, a third-world country, data are further limited; only one related study has been conducted so far. The purpose of this study is to retrospectively report our single-institutional experience of SILS in terms of feasibility, safety and perioperative outcomes in the management of various gynecologic conditions...
2017: F1000Research
https://www.readbyqxmd.com/read/28973005/a-systematic-review-of-cost-effectiveness-studies-comparing-conventional-biological-and-surgical-interventions-for-inflammatory-bowel-disease
#15
REVIEW
Nadia Pillai, Mark Dusheiko, Bernard Burnand, Valérie Pittet
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic disease placing a large health and economic burden on health systems worldwide. The treatment landscape is complex with multiple strategies to induce and maintain remission while avoiding long-term complications. The extent to which rising treatment costs, due to expensive biologic agents, are offset by improved outcomes and fewer hospitalisations and surgeries needs to be evaluated. This systematic review aimed to assess the cost-effectiveness of treatment strategies for IBD...
2017: PloS One
https://www.readbyqxmd.com/read/28936435/impact-of-enhanced-recovery-after-surgery-protocols-on-postoperative-morbidity-and-mortality-in-patients-undergoing-routine-hepatectomy-review-of-the-current-evidence
#16
Rahul Damania, Andrei Cocieru
BACKGROUND: Enhanced recovery protocols are widely used in many areas of general surgery but had a limited penetration in perioperative management of patients undergoing liver resection. Recently, multiple publications described application of enhanced recovery after surgery (ERAS) program to hepatectomy patients but their definitive role is not established or accepted by hepatobiliary surgeons. METHODS: A comprehensive literature review of published series in English language medical sources detailing ERAS program application for hepatectomy for the period of 2006-2016 is performed...
September 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28893013/effects-of-intraperitoneal-local-anaesthetics-bupivacaine-and-ropivacaine-versus-placebo-on-postoperative-pain-after-laparoscopic-cholecystectomy-a-randomised-double-blind-study
#17
Neha T Das, Charulata Deshpande
INTRODUCTION: Laparoscopic Cholecystectomy (LC) is the most frequently performed elective daycare surgery and provision of postoperative pain relief is of importance. After laparoscopic cholecystectomy shoulder and abdominal pain causes considerable distress. Visceral pain during coughing, respiration and mobilization increases morbidity, hospital stay and costs. AIM: To compare the analgesic efficacy of intraperitoneally instilled equipotent concentrations of bupivacaine and ropivacaine versus placebo in relieving postoperative pain after laparoscopic cholecystectomy when used as a part of multimodal analgesia...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28877952/effectiveness-and-cost-effectiveness-of-a-cardiovascular-risk-prediction-algorithm-for-people-with-severe-mental-illness-primrose
#18
Ella Zomer, David Osborn, Irwin Nazareth, Ruth Blackburn, Alexandra Burton, Sarah Hardoon, Richard Ian Gregory Holt, Michael King, Louise Marston, Stephen Morris, Rumana Omar, Irene Petersen, Kate Walters, Rachael Maree Hunter
OBJECTIVES: To determine the cost-effectiveness of two bespoke severe mental illness (SMI)-specific risk algorithms compared with standard risk algorithms for primary cardiovascular disease (CVD) prevention in those with SMI. SETTING: Primary care setting in the UK. The analysis was from the National Health Service perspective. PARTICIPANTS: 1000 individuals with SMI from The Health Improvement Network Database, aged 30-74 years and without existing CVD, populated the model...
September 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28871584/selected-aspects-of-medical-care-for-patients-with-asthma-and-chronic-obstructive-pulmonary-disease-copd-in-poland
#19
Joanna Miłkowska-Dymanowska, Adam J Białas, Paweł Górski
INTRODUCTION: Noncompliance with healthcare undoubtedly has a strong influence on the high prevalence of uncontrolled obstructive diseases. The aim of our study was to evaluate the quality of medical conduct in patients with asthma or chronic obstructive lung diseases (COPD), with encompassed two-levelled system of health care. MATERIAL AND METHODS: A survey of general practitioners (GP), allergists and pulmonologists practicing in Poland was performed between September and December 2016...
2017: Advances in Respiratory Medicine
https://www.readbyqxmd.com/read/28836446/modified-brostr%C3%A3-m-procedure-using-distal-fibular-periosteal-flap-augmentation-vs-anatomic-reconstruction-using-a-free-tendon-allograft-in-patients-who-are-not-candidates-for-standard-repair
#20
Hong Joon Choi, Dae Wook Kim, Jea Seok Park
BACKGROUND: The modified Broström procedure (MBP) is widely accepted as the primary operative treatment for chronic lateral ankle instability (CLAI). However, the MBP does not produce good clinical results in all patients, and anatomic reconstruction using a free tendon graft may be considered in those patients. The purpose of this study was to evaluate the efficacy of the MBP using distal fibular periosteal flap augmentation for CLAI in patients who were not candidates for standard repair...
November 2017: Foot & Ankle International
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