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https://www.readbyqxmd.com/read/28063329/determination-of-ethyl-glucuronide-in-human-hair-samples-a-multivariate-analysis-of-the-impact-of-extraction-conditions-on-quantitative-results
#1
Alexander Mueller, Hilke Jungen, Stefanie Iwersen-Bergmann, Lars Raduenz, Susanne Lezius, Hilke Andresen-Streichert
BACKGROUND: Ethyl glucuronide (EtG), a minor metabolite of ethanol, is used as a direct alcohol biomarker for the prolonged detection of ethanol consumption. Hair testing for EtG offers retrospective, long-term detection of ethanol exposition for several months and has gained practical importance in forensic and clinical toxicology. Since quantitative results of EtG hair testings are included in interpretations, a rugged quantitation of EtG in hair matrix is important. As generally known, sample preparation is critical in hair testing, and the scope of this study was on extraction of EtG from hair matrix...
December 19, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27988322/a-multi-centre-evaluation-of-eleven-clinically-feasible-brain-pet-mri-attenuation-correction-techniques-using-a-large-cohort-of-patients
#2
Claes N Ladefoged, Ian Law, Udunna Anazodo, Keith St Lawrence, David Izquierdo-Garcia, Ciprian Catana, Ninon Burgos, M Jorge Cardoso, Sebastien Ourselin, Brian Hutton, Inés Mérida, Nicolas Costes, Alexander Hammers, Didier Benoit, Søren Holm, Meher Juttukonda, Hongyu An, Jorge Cabello, Mathias Lukas, Stephan Nekolla, Sibylle Ziegler, Matthias Fenchel, Bjoern Jakoby, Michael E Casey, Tammie Benzinger, Liselotte Højgaard, Adam E Hansen, Flemming L Andersen
AIM: To accurately quantify the radioactivity concentration measured by PET, emission data need to be corrected for photon attenuation; however, the MRI signal cannot easily be converted into attenuation values, making attenuation correction (AC) in PET/MRI challenging. In order to further improve the current vendor-implemented MR-AC methods for absolute quantification, a number of prototype methods have been proposed in the literature. These can be categorized into three types: template/atlas-based, segmentation-based, and reconstruction-based...
December 14, 2016: NeuroImage
https://www.readbyqxmd.com/read/27978586/-20-years-of-bilateral-cochlear-implantation-an-analysis-of-the-implanted-patients
#3
A Radeloff, M Neckel, W Shehata-Dieler, K Rak, S P Schraven, W Großmann, R Hagen
Binaural hearing is essential for localization abilities and improves the speech perception in noise. Since 20 years, bilateral cochlear implantation is routinely performed to restore binaural hearing. In this cross-sectional study, we evaluated speech perception in quiet (Freiburger monosyllables, Hochmair-Schulz-Moser (HSM) sentence test, each at 70 dB) and in noise (HSM test, signal-to-noise ratio 10 dB) in 103 out of 165 adult patients who were bilaterally implanted in Würzburg between 1995 and June 2014...
December 15, 2016: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/27974626/bio-compute-objects-a-step-towards-evaluation-and-validation-of-bio-medical-scientific-computations
#4
Vahan Simonyan, Jeremy Goecks, Raja Mazumder
The unpredictability of actual physical, chemical, and biological experiments due to the multitude of environmental and procedural factors is well-documented. What is systematically overlooked, however, is that computational biology algorithms are also affected by multiplicity of parameters and have no lesser volatility. The complexities of computation protocols and interpretation of outcomes is only a part of the challenge: there are also virtually no standardized and industry accepted metadata schemas for reporting the computational objects that record the parameters used for computations together with the results of computations...
December 14, 2016: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/27960229/automated-telephone-communication-systems-for-preventive-healthcare-and-management-of-long-term-conditions
#5
REVIEW
Pawel Posadzki, Nikolaos Mastellos, Rebecca Ryan, Laura H Gunn, Lambert M Felix, Yannis Pappas, Marie-Pierre Gagnon, Steven A Julious, Liming Xiang, Brian Oldenburg, Josip Car
BACKGROUND: Automated telephone communication systems (ATCS) can deliver voice messages and collect health-related information from patients using either their telephone's touch-tone keypad or voice recognition software. ATCS can supplement or replace telephone contact between health professionals and patients. There are four different types of ATCS: unidirectional (one-way, non-interactive voice communication), interactive voice response (IVR) systems, ATCS with additional functions such as access to an expert to request advice (ATCS Plus) and multimodal ATCS, where the calls are delivered as part of a multicomponent intervention...
14, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27938536/acute-appendicitis-should-the-laparoscopic-approach-be-proposed-as-the-gold-standard-six-year-experience-in-an-emergency-surgery-unit
#6
G Guercio, G Augello, L Licari, A Dafnomili, C Raspanti, N Bagarella, N Falco, G Rotolo, T Fontana, C Porello, G Gulotta
Acute appendicitis is common in an Emergency Surgery Unit. Although the laparoscopic approach is a method accepted for its treatment, no strong data are available for determining how many procedures must an experienced surgeon carry out for obtaining all the advantages of this technique and if this approach can become the gold standard in the activity of a general emergency unit with senior surgeons variously skilled on the basic laparoscopy. 142 patients that underwent appendectomy (90 laparoscopic, 52 conventional) for acute appendicitis were enrolled in this institutional retrospective cohort study...
July 2016: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/27930509/current-challenges-in-providing-bariatric-surgery-in-france-a-nationwide-study
#7
Sébastien Czernichow, Michel Paita, David Nocca, Simon Msika, Arnaud Basdevant, Bertrand Millat, Anne Fagot-Campagna
Bariatric surgery is a well-accepted procedure for severe and massive obesity management. We aimed to determine trends, geographical variations, and factors influencing bariatric surgery and the choice of procedure in France in a large observational study.The Health Insurance Fund for Salaried Workers (Caisse National Assurance Maladie Travailleurs Salariés) covers about 86% of the French population. The Système National d'Information Inter-régimes de l'Assurance Maladie database contains individualized and anonymized patient data on all reimbursements for healthcare expenditure...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27917852/results-of-bronchoscopic-excision-in-typical-carcinoid-tumors-of-the-lung-in-turkey
#8
Hilal Boyacı, Mustafa Çörtük, Şule Gül, Elif Tanrıverdi, Mehmet Akif Özgül, Hüseyin Erhan Dinçer, Erdoğan Çetinkaya
Aim Carcinoid tumors of the lung are the tumors originating from the neuroendocrine cells. Surgical excision remains the gold standard for the treatment. Treatment with interventional bronchoscopic excision has also been reported as an alternative option in typical carcinoid tumors of the lung. The aim of this study was to present results and outcomes in patients who were bronchoscopically treated and followed-up. Methods Data of 14 patients, who had undergone bronchoscopic excision due to typical carcinoid tumor of the lung between April 2008 and July 2015 were retrospectively evaluated...
February 1, 2017: Medicinski Glasnik
https://www.readbyqxmd.com/read/27916473/aseptic-revision-knee-arthroplasty-with-total-stabilizer-prostheses-achieves-similar-functional-outcomes-to-primary-total-knee-arthroplasty-at-2-years-a-longitudinal-cohort-study
#9
David F Hamilton, Philip M Simpson, James T Patton, Colin R Howie, Richard Burnett
BACKGROUND: Patient function is poorly characterized following revision total knee arthroplasty (TKA), although is generally accepted to be inferior to that following primary procedures. METHODS: Fifty-three consecutive aseptic revisions to total stabilizer devices were prospectively evaluated, preoperatively and at 6, 26, 52, and 104 weeks postoperatively, using the Oxford Knee Score (OKS), range of motion, pain rating scale, and timed functional performance battery...
October 31, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27908187/dosimetric-characterization-of-mri-only-treatment-planning-for-brain-tumors-in-atlas-based-pseudo-ct-images-generated-from-standard-t1-weighted-mr-images
#10
Benjamin Demol, Christine Boydev, Juha Korhonen, Nick Reynaert
PURPOSE: Magnetic resonance imaging (MRI)-only radiotherapy treatment planning requires accurate pseudo-CT (pCT) images for precise dose calculation. The current work introduced an atlas-based method combined with MR intensity information. pCT analyses and Monte Carlo dose calculations for intracranial stereotactic treatments were performed. METHODS: Twenty-two patients, representing 35 tumor targets, were scanned using a 3D T1-weighted MRI sequence according to the clinical protocol...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27875159/evaluating-the-impact-of-binning-2d-scalar-fields
#11
Lace Padilla, P Samuel Quinan, Miriah Meyer, Sarah H Creem-Regehr
The expressiveness principle for visualization design asserts that a visualization should encode all of the available data, and only the available data, implying that continuous data types should be visualized with a continuous encoding channel. And yet, in many domains binning continuous data is not only pervasive, but it is accepted as standard practice. Prior work provides no clear guidance for when encoding continuous data continuously is preferable to employing binning techniques or how this choice affects data interpretation and decision making...
January 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/27845044/a-morphological-identification-cell-cytotoxicity-assay-using-cytoplasm-localized-fluorescent-probe-clfp-to-distinguish-living-and-dead-cells
#12
Fangfang Lai, Zhengwei Shen, Hui Wen, Jialing Chen, Xiang Zhang, Ping Lin, Dali Yin, Huaqing Cui, Xiaoguang Chen
Cell cytotoxicity assays include cell activity assays and morphological identification assays. Currently, all frequently used cytotoxicity assays belong to cell activity assays but suffer from detection limitations. Morphological identification of cell death remains as the gold standard, although the method is difficult to scale up. At present there is no generally accepted morphological identification based cell cytotoxicity assay. In this study, we applied previous developed cell cytoplasm-localized fluorescent probe (CLFP) to display cell morphologies...
January 8, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27823593/snorkel-endovascular-abdominal-aortic-aneurysm-repair-versus-fenestrated-endovascular-aneurysm-repair-is-it-a-competition
#13
REVIEW
Adam Tanious, Jason T Lee, Murray Shames
The endovascular treatment of juxtarenal abdominal aortic aneurysm (AAA) can be performed by either a standard endovascular stent graft with additional snorkle grafts to aorta branches (snorkel endovascular aneurysm repair) or implantation of a fenestrated stent graft (fenestrated endovascular aneurysm repair). While many vascular surgeons consider snorkel endovascular aneurysm repair and fenestrated endovascular aneurysm repair to be competing techniques or alternate strategies, published procedural outcomes suggest more complementary roles...
March 2016: Seminars in Vascular Surgery
https://www.readbyqxmd.com/read/27790289/challenging-the-knowledge-base-and-skillset-for-providing-surgical-consent-by-orthopedic-and-plastic-surgeons-in-the-netherlands-an-identified-area-of-improvement-in-patient-safety
#14
Wouter K G Leclercq, Sarah Sloot, Bram J Keulers, Saskia Houterman, Johan Legemaate, Margot Veerman, Leslie Thomas, Marc R Scheltinga
BACKGROUND: Successfully completing a surgical informed consent process is an important element of the preoperative consult. A previous study of Dutch general surgeons demonstrated that the implementation of SIC did not meet acceptable standards. However, the quality of the SIC process in the orthopedic surgical or plastic surgical arena is unknown. METHODS: Following ethical approval, an online survey investigating specifics of surgical informed consent was performed among members of the Dutch Scientific Association of Orthopedic Surgeons and the Dutch Society for Plastic Surgery...
2016: Patient Safety in Surgery
https://www.readbyqxmd.com/read/27754015/br-04-1management-of-treatment-resistant-hypertension
#15
David John Webb
Treatment-resistant hypertension (TRH) is defined as the failure to achieve an office BP target of <140/90 mmHg (<130/80 mmHg in patients with chronic kidney disease (CKD) or diabetes) in patients with hypertension (HT), despite adherence to at least 3 antihypertensive medications at optimal tolerated doses, ideally including a diuretic (Calhoun et al., Circulation 2008). TRH identifies patients with hard-to-treat HT, who might benefit from specialist investigation and treatment. Although some studies put the prevalence of TRH as >10%, these levels may be inflated by white-coat hypertension and poor adherence...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27741134/validity-of-apcs-score-as-a-risk-prediction-score-for-advanced-colorectal-neoplasia-in-chinese-asymptomatic-subjects-a-prospective-colonoscopy-study
#16
Wenbin Li, Lili Zhang, Jianyu Hao, Yongdong Wu, Di Lu, Haiying Zhao, Zhenjie Wang, Tianming Xu, Hong Yang, Jiaming Qian, Jingnan Li
The Asia-Pacific Colorectal Screening (APCS) score is a risk-stratification tool that helps predict the risk for advanced colorectal neoplasia (ACN) in asymptomatic Asian populations, but has not yet been assessed for its validity of use in Mainland China.The aim of the study was to assess the validity of APCS score in asymptomatic Chinese population, and to identify other risk factors associated with ACN.Asymptomatic subjects (N = 1010) who underwent colonoscopy screening between 2012 and 2014 in Beijing were enrolled...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27730284/quality-indicators-of-continuous-renal-replacement-therapy-crrt-care-in-critically-ill-patients-a-systematic-review
#17
REVIEW
Oleksa G Rewa, Pierre-Marc Villeneuve, Philippe Lachance, Dean T Eurich, Henry T Stelfox, R T Noel Gibney, Lisa Hartling, Robin Featherstone, Sean M Bagshaw
OBJECTIVES: Renal replacement therapy is increasingly utilized in the intensive care unit (ICU), of which continuous renal replacement therapy (CRRT) is most common. Despite CRRT being a relatively invasive and resource intensive technology, there remains wide practice variation in its application. This systematic review appraised the evidence for quality indicators (QIs) of CRRT care in critically ill patients. DESIGN: A comprehensive search strategy was developed and performed in five citation databases (Medline, Embase, CINAHL, Cochrane Library, and PubMed) and select grey literature sources...
October 11, 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/27720867/the-role-of-test-retest-reliability-in-measuring-individual-and-group-differences-in-executive-functioning
#18
Kenneth R Paap, Oliver Sawi
BACKGROUND: Studies testing for individual or group differences in executive functioning can be compromised by unknown test-retest reliability. NEW METHOD: Test-retest reliabilities across an interval of about one week were obtained from performance in the antisaccade, flanker, Simon, and color-shape switching tasks. There is a general trade-off between the greater reliability of single mean RT measures, and the greater process purity of measures based on contrasts between mean RTs in two conditions...
December 1, 2016: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27720605/a-fuzzy-logic-based-decision-making-approach-for-identification-of-groundwater-quality-based-on-groundwater-quality-indices
#19
M Vadiati, A Asghari-Moghaddam, M Nakhaei, J Adamowski, A H Akbarzadeh
Due to inherent uncertainties in measurement and analysis, groundwater quality assessment is a difficult task. Artificial intelligence techniques, specifically fuzzy inference systems, have proven useful in evaluating groundwater quality in uncertain and complex hydrogeological systems. In the present study, a Mamdani fuzzy-logic-based decision-making approach was developed to assess groundwater quality based on relevant indices. In an effort to develop a set of new hybrid fuzzy indices for groundwater quality assessment, a Mamdani fuzzy inference model was developed with widely-accepted groundwater quality indices: the Groundwater Quality Index (GQI), the Water Quality Index (WQI), and the Ground Water Quality Index (GWQI)...
October 6, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27685187/expectations-for-the-methodology-and-translation-of-animal-research-a-survey-of-the-general-public-medical-students-and-animal-researchers-in-north-america
#20
Ari R Joffe, Meredith Bara, Natalie Anton, Nathan Nobis
To determine what are considered acceptable standards for animal research (AR) methodology and translation rate to humans, a validated survey was sent to: a) a sample of the general public, via Sampling Survey International (SSI; Canada), Amazon Mechanical Turk (AMT; USA), a Canadian city festival (CF) and a Canadian children's hospital (CH); b) a sample of medical students (two first-year classes); and c) a sample of scientists (corresponding authors and academic paediatricians). There were 1379 responses from the general public sample (SSI, n = 557; AMT, n = 590; CF, n = 195; CH, n = 102), 205/330 (62%) medical student responses, and 23/323 (7%, too few to report) scientist responses...
September 2016: Alternatives to Laboratory Animals: ATLA
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