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hidradenitis suppurativa

Claudio Marasca, Giovanni Vivona, Maria C Annunziata, Sara Cacciapuoti, Emilia Capasso, Alessandra Ciotola, Gianmarco Russo, Gabriella Fabbrocini
No abstract text is available yet for this article.
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Valentina Benzecry, Anna Grancini, Elena Guanziroli, Gianluca Nazzaro, Mauro Barbareschi, Angelo V Marzano, Simona Muratori, Stefano Veraldi
BACKGROUND: Hidradenitis suppurativa is a chronic inflammatory disease of the hair follicle that usually involves specific anatomic areas which are partially occluded, have a higher density of eccrine and apocrine sweat glands and a higher pH. These characteristics could promote the superinfection of certain group of bacteria. We aimed to describe the bacteria that can be isolated from hidradenitis lesions and to establish a correlation between bacteriological results and clinical data...
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Yvan D Pacheco, Orlando García-Duque, Javier Fernández-Palacios
Lymphedema is the result of an alteration of the lymphatic drainage, and its most common worldwide cause is filariasis. In our practice usually is associated to neoplasic, inflammatory and granulomatous processes, radiotherapy, hydroelectrolytic disbalances, and idiopathic. It can affect any part of the body, including the penis and scrotum. The genital lymphedema is a rare presentation, it corresponds to 0.6% of lymphedema. However, causes serious functional, social and emotional limitations for the patient...
2018: Cirugia y Cirujanos
Ditte Marie Lindhardt Saunte, Gregor Borut Ernst Jemec
No abstract text is available yet for this article.
April 17, 2018: JAMA: the Journal of the American Medical Association
Issra Rashed, James S Welsh
No abstract text is available yet for this article.
April 17, 2018: JAMA: the Journal of the American Medical Association
Ximena Wortsman
No abstract text is available yet for this article.
April 17, 2018: JAMA: the Journal of the American Medical Association
Simon Francis Thomsen
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with profound negative impact on quality of life. Adalimumab (anti-TNF) is indicated for moderate-to-severe HS unresponsive to conventional therapy. Herein, studies of the change in Dermatology Life Quality Index (DLQI) among patients with HS treated with adalimumab are reviewed. The anticipated gain in DLQI is only modest in patients with HS treated with adalimumab, even in trials of high quality, and does not exceed the established minimal clinically important difference...
April 19, 2018: Journal of Dermatological Treatment
Amit Garg, Sara Wertenteil, Rebekah Baltz, Andrew Strunk, Nika Finelt
The prevalence of Hidradenitis Suppurativa (HS) in the pediatric population is unknown. We sought to establish standardized overall as well as gender-, age-, and race-specific prevalence estimates of HS among children and adolescents in the United States. We performed a cross-sectional analysis in a heterogeneous sample of 55 million patients across all census regions. We identified 1,240 HS patients in whom the ratio of girls to boys was 3.8:1. Almost all (96.8%) HS patients were ≥10 years of age. Overall HS prevalence was 0...
April 13, 2018: Journal of Investigative Dermatology
Joachim Dissemond, Finja Jockenhöfer, Anya Miller, Günter Kurzhals, Shahrouz Noori, Stefanie Reich-Schupke, Martin Schlaeger, Erich Schubert, Markus Stücker, Tobias Weberschock, Hans Wilfried Jungkunz
The objective of the present S1 guidelines is to present current knowledge about dermatologically relevant diseases associated with localized dermal lymphostasis, thus facilitating their early detection, diagnostic workup, and targeted treatment. Whenever possible, treatment should be based on stage-appropriate and clearly defined algorithms. The numerous issues regarding differential diagnosis and treatment clinicians are confronted with in everyday clinical practice seem to warrant the publication of up-to-date guidelines...
April 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
Andrea Chiricozzi, Stefano Veraldi, Gabriella Fabbrocini, Biagio Didona, Sandro Pasquinucci, Giuseppe Micali, Marco Romanelli
No abstract text is available yet for this article.
April 5, 2018: European Journal of Dermatology: EJD
Rahel Thomi, Simone Cazzaniga, S Morteza Seyed Jafari, Christoph Schlapbach, Robert E Hunger
Importance: In spite of progress in understanding the mechanisms underlying hidradenitis suppurativa (HS) as an inflammatory skin disease, there is still a demand for an overview on immunopathogenesis of HS. Objective: To demonstrate the importance of the type 1/type 17 immune response in lesional HS skin by drawing a semantic connectivity map. Design, Setting, and Participants: Single-center case series of 24 patients with HS. Association of HS with T helper 1/T helper 17 (TH1/TH17) phenotype was assessed using semantic map analysis...
April 4, 2018: JAMA Dermatology
Mohan Liu, Jacob Degner, Justin Wade Davis, Kenneth B Idler, Ahmed Nader, Nael M Mostafa, Jeffrey F Waring
Anti-drug antibody formation occurs with most biological agents across disease states, but the mechanism by which they are formed is unknown. The formation of anti-drug antibodies to adalimumab (AAA) may decrease its therapeutic effects in some patients. HLA alleles have been reported to be associated with autoantibody formation against interferons and other TNF inhibitors, but not adalimumab. We analyzed samples from 634 subjects with either rheumatoid arthritis (RA) or hidradenitis suppurativa (HS): 37 subjects (17 RA and 20 HS) developed AAA (AAA+) during adalimumab treatment and 597 subjects (348 RA, 249 HS) did not develop AAA (AAA-) during the clinical trials...
2018: PloS One
Clio Dessinioti, Vassiliki Tzanetakou, Chrisa Zisimou, George Kontochristopoulos, Christina Antoniou
BACKGROUND: The mean age of onset of hidradenitis suppurativa (HS) is between 20 and 24 years. Very few data about patients with early-onset HS exist. OBJECTIVE: To investigate the association of early-onset HS with the clinical characteristics: age, gender, body mass index (BMI), smoking, family history of HS, Hurley stage, and number of areas affected. METHODS: This was a retrospective study of the reported early age at HS onset (≤17 years old) with clinical characteristics and with the severity of HS at first consultation visit...
March 31, 2018: International Journal of Dermatology
L Emtestam, K Sartorius
No abstract text is available yet for this article.
March 2018: British Journal of Dermatology
R Micheletti
No abstract text is available yet for this article.
March 2018: British Journal of Dermatology
Stephanie Chapman, Daniel Delgadillo III, Cara Barber, Amor Khachemoune
Hidradenitis suppurativa (HS) is a chronic and debilitating skin disorder characterized by the formation of painful abscesses, draining sinus tracts, and scarring, predominantly in skin folds such as the axillae and the perineum. The exact prevalence of HS is unknown because the disease is often underreported, but it has been estimated to be as high as 4.1%. HS is three times more prevalent in women than in men. Various comorbidities have been associated with HS, including inflammatory bowel disease and squamous cell carcinoma (SCC)...
March 2018: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
Lisa Scholl, Schapoor Hessam, Uwe Bergmann, Falk G Bechara
No abstract text is available yet for this article.
March 2018: Journal of Cutaneous Medicine and Surgery
Taylor L Braunberger, Cynthia L Nicholson, Lauren Gold, Amanda F Nahhas, Gordon Jacobsen, Angela Parks-Miller, Iltefat H Hamzavi
BACKGROUND: Although recent hidradenitis suppurativa studies have shown that early-onset disease is associated with a positive family history and more widespread disease, research in pediatric hidradenitis suppurativa is limited. METHODS: Thirty-three children diagnosed with hidradenitis suppurativa during an 18-month period were included in this institutional review board-approved, retrospective chart review. Information on demographic characteristic, family history, and timing of onset (prepubescent vs postpubescent) was extracted...
March 25, 2018: Pediatric Dermatology
Luís Mata Ribeiro, Ana Silva Guerra
Hidrosadenitis supurativa is a chronic inflammatory disease with great physical and psychological impact. Although conservative treatments may be effective in mild forms of the disease, extensive surgical resection and reconstruction are necessary in more severe forms of the disease. The purpose of this paper is to describe our two-stage reconstructive procedure regarding this kind of disease. We present a clinical case of a patient with severe, bilateral axillary hidrosadenitis. In the first surgical step we excised the lesions and applied the artificial dermis secured with negative pressure wound therapy...
January 31, 2018: Acta Médica Portuguesa
B C Melnik, S M John, W Chen, G Plewig
BACKGROUND: Disintegration of the infundibula of terminal hair follicles (HF) in intertriginous skin areas exhibits the histological hallmark of hidradenitis suppurativa (HS)/acne inversa, featuring a dissecting terminal hair folliculitis. Elevated serum levels of interleukin 17 and local increase in the ratio of proinflammatory Th17 cells and antiinflammatory regulatory T cells (Tregs) have been reported. Perifollicular Tregs play a key role for HF stem cell homeostasis and infundibular integrity...
March 24, 2018: British Journal of Dermatology
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