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hidradenitis suppurativa

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https://www.readbyqxmd.com/read/27913316/actinotignum-schaalii-subcutaneous-abscesses-in-a-patient-with-hidradenitis-suppurativa-case-report-and-literature-review
#1
REVIEW
Sofia Maraki, George Evangelou, Dimitra Stafylaki, Efstathia Scoulica
Actinotignum schaalii (formerly Actinobaculum schaalii) is a Gram-positive, facultative anaerobic rod that is typically involved in urinary tract infections in elderly patients or those with underlying urological pathologies. In contrast, abscess formation caused by A. schaalii is very rare. We present a case of multiple abscesses in the perineal area in a young patient with hidradenitis suppurativa associated with A. schaalii and Prevotella melaninogenica and review the relevant literature on the topic.
November 29, 2016: Anaerobe
https://www.readbyqxmd.com/read/27911007/assessment-of-subclinical-atherosclerosis-in-hidradenitis-suppurativa
#2
José C Pascual, Iris González, Diego Corona, Patricia Hispán, José M Ramos, José Sánchez-Paya, Gregor B Jemec
BACKGROUND: Patients with Hidradenitis Suppurativa (HS) have an increased prevalence of traditional cardiovascular (CV) risk factors. OBJECTIVE: Our aim was to investigate the association between subclinical atherosclerosis, detected by carotid ultrasound, and HS. METHODS: A prospective observation and analytical study assessing subclinical atherosclerosis using carotid ultrasound in patients with HS. RESULTS: A total of 62 HS-patients and 62 matched-controls were studied...
December 2, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27900998/novel-mutations-in-psenen-gene-in-two-chinese-acne-inversa-families-manifested-as-familial-multiple-comedones-and-dowling-degos-disease
#3
Cheng Zhou, Guang-Dong Wen, Lwin Myint Soe, Hong-Jun Xu, Juan Du, Jian-Zhong Zhang
BACKGROUND: Acne inversa (AI), also called hidradenitis suppurativa, is a chronic, inflammatory, recurrent skin disease of the hair follicle. Familial AI shows autosomal-dominant inheritance caused by mutations in the γ-secretase genes. This study was aimed to identify the specific mutations in the γ-secretase genes in two Chinese families with AI. METHODS: In this study, two Chinese families with AI were investigated. All the affected individuals in the two families mainly manifested with multiple comedones, pitted scars, and a few inflammatory nodules on their face, neck, trunk, axilla, buttocks, upper arms, and thighs...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27896279/a-case-of-relapsing-polyarthritis-associated-with-hidradenitis-suppurativa-case-report-and-review-of-literature
#4
Avinash Adiga, John Pixley
Hidradenitis suppurativa (HS) is a chronic, inflammatory follicular skin disease with recurrent skin nodules, sinus tracts, and scarring. We observed a case of HS associated with relapsing polyarthritis. On presentation the patient had a flare of polyarthritis with an increase in the number and size of pustular nodules. He has had similar episodes 1 to 2 times yearly subsiding with antibiotic treatment. Radiographs revealed erosions and demineralization. Symptoms improved following institution of anti-inflammatory and antibiotic therapy...
October 2016: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/27882387/bacterial-colonization-in-hidradenitis-suppurativa-acne-inversa-a-cross-sectional-study-of-50-patients-and-review-of-the-literature
#5
Georgios Nikolakis, Aikaterini I Liakou, Stefanos Bonovas, Holger Seltmann, Nikolaos Bonitsis, Olivier Join-Lambert, Thomas Wild, Ioannis Karagiannidis, Silvia Zolke-Fischer, Klaus Langner, Christos C Zouboulis
It is unclear whether bacterial colonization in hidradenitis suppurativa/acne inversa (HS) comprises a primary cause, triggering factor or secondary phenomenon of the disease pathogenesis. Furthermore, the connection between certain bacterial species, the disease severity and its localization is unknown. Bacterial species were isolated from HS lesions to reveal a potential correlation with localization and disease severity. Ninety swab tests were prospectively obtained from 90 HS lesions of 50 consecutive patients...
November 24, 2016: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/27862787/two-diseases-one-remedy-systemic-amyloidosis-secondary-to-hidradenitis-suppurativa-treatment-with-infliximab
#6
İlkay Özer, Cengiz Karaçin, Esra Adışen, Galip Güz, Mehmet Ali Gürer
Hidradenitis suppurativa, known as acne inversa, is a relapsing and chronic inflammatory skin disease affecting the skin folds. During the chronic course of the disease many local complications like fistulae to other tissues or systemic complications including anemia, secondary amyloidosis, lymphedema, nephrotic syndrome, artropathy may take place. Amyloid A amyloidosis is a rare complication of hidradenitis suppurativa, which has been described in a limited number of case reports. Herein, we present such a patient that had developed AA amyloidosis during the course of hidradenitis suppurativa...
November 12, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27854113/epidemiology-clinical-features-associated-comorbidities-and-treatment
#7
Guy Shalom
INTRODUCTION: Hidradenitis suppurativa (HS) is a chronic relapsing suppurativa skin disease localized in the apocrine-gland-bearing areas of the body, predominantly in the axillae and groin. EVIDENCE ACQUISITION: Although important risk factors have been identified, the pathomechanisms of the disease have not been fully understood. In the absence of proper treatment chronic inflammation results in debilitating, and sometimes life-threatening complications. EVIDENCE SYNTHESIS: This severe and chronic disease can have detrimental effects on self-esteem and quality of life and is associated with high comorbidity, such as the metabolic syndrome and its components...
November 17, 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/27843924/south-italy-a-privileged-perspective-to-understand-the-relationship-between-hidradenitis-suppurativa-and-overweight-obesity
#8
Gabriella Fabbrocini, Valerio De Vita, Marianna Donnarumma, Giuseppe Russo, Giuseppe Monfrecola
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that involves the terminal hair follicles of apocrine gland-bearing skin areas. OBJECTIVE: To evaluate the relationship between HS and systemic medical conditions, such as overweight/obesity during adolescence. METHODS: Epidemiologic data was collected from January 2014 up to December 2015 from 27 patients affected by HS, outpatients of the Dermatology Department of University of Naples Federico II, to examine the correlation between HS and overweight/obesity...
September 2016: Skin Appendage Disorders
https://www.readbyqxmd.com/read/27843200/mmp8-is-increased-in-lesions-and-blood-of-acne-inversa-patients-a-potential-link-to-skin-destruction-and-metabolic-alterations
#9
Athanasia Tsaousi, Ellen Witte, Katrin Witte, Hans-Joachim Röwert-Huber, Hans-Dieter Volk, Wolfram Sterry, Kerstin Wolk, Sylke Schneider-Burrus, Robert Sabat
Acne inversa (AI; also designated as hidradenitis suppurativa) is a chronic inflammatory disease with still unknown pathogenesis that affects the intertriginous skin of perianal, inguinal, and axillary sites. It leads to painful nodules, abscesses, and fistulas with malodorous secretion and is frequently associated with metabolic alterations. Here, we demonstrate that one of the most highly upregulated molecules in AI lesions is matrix metalloproteinase 8 (MMP8), an enzyme specialized in the degradation of extracellular matrix components and the HDL component apolipoprotein A-I...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27837158/development-of-a-quality-of-life-measure-for-hidradenitis-suppurativa
#10
Mia Sisic, Joslyn S Kirby, Sanwarjit Boyal, Lisa Plant, Chelsea McLellan, Jerry Tan
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic skin disorder with adverse impacts on both physical and psychosocial well-being. There is presently no validated HS-specific quality-of-life (QoL) measure. OBJECTIVE: The objective of this study is to develop a QoL instrument for HS (HS-QoL) in accordance with recommended standards. METHODS: Patient interviews (concept elicitation) and expert input were used to develop the conceptual framework for outcomes perceived important to patients with HS...
November 11, 2016: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27830291/-cutaneous-involvement-in-chronic-inflammatory-bowel-disease-crohn-s-disease-and-ulcerative-colitis
#11
REVIEW
L Richter, K Rappersberger
BACKGROUND: Over recent decades, both the incidence and prevalence of chronic inflammatory bowel disease have continued to rise in industrialized countries; the disease is frequently associated with extracutaneous involvement and comorbidity. OBJECTIVES: The purpose of this work was to investigate the frequency and specificity of mucocutaneous manifestations in Crohn's disease (CD) and ulcerative colitis (UC). MATERIALS AND METHODS: An extensive search in peer-reviewed journals via PubMed was performed; presented is a summary and analysis of various studies and data, including data of patients treated at our department...
December 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27828627/inflammasomes-and-dermatology
#12
Daniel Coelho de Sá, Cyro Festa
Inflammasomes are intracellular multiprotein complexes that comprise part of the innate immune response. Since their definition, inflammasome disorders have been linked to an increasing number of diseases. Autoinflammatory diseases refer to disorders in which local factors lead to the activation of innate immune cells, causing tissue damage when in the absence of autoantigens and autoantibodies. Skin symptoms include the main features of monogenic inflammasomopathies, such as Cryopyrin-Associated Periodic Syndromes (CAPS), Familial Mediterranean Fever (FMF), Schnitzler Syndrome, Hyper-IgD Syndrome (HIDS), PAPA Syndrome, and Deficiency of IL-1 Receptor Antagonist (DIRA)...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27819713/impairment-of-sexual-life-in-3-485-dermatological-outpatients-from-a-multicentre-study-in-13-european-countries
#13
Francesca Sampogna, Damiano Abeni, Uwe Gieler, Lucía Tomas-Aragones, Lars Lien, Géraldine Titeca, Gregor B E Jemec, Laurent Misery, Csanád Szabó, M Dennis Linder, Andrea W M Evers, Jon Anders Halvorsen, Flora Balieva, Jacek C Szepietowski, Dmitry V Romanov, Servando E Marron, Ilknur K Altunay, Andrew Y Finlay, Sam S Salek, Jörg Kupfer, Florence Dalgard
Skin conditions may have a strong impact on patients' sexual life, and thus influence personal relationships. Sexual issues are difficult to discuss directly in clinical practice, and a mediated instrument may be useful to capture such information. In this study item 9 of the Dermatology Life Quality Index was used to collect information on sexual impact of several skin conditions in 13 European countries. Among 3,485 patients, 23.1% reported sexual problems. The impairment was particularly high in patients with hidradenitis suppurativa, prurigo, blistering disorders, psoriasis, urticaria, eczema, infections of the skin, or pruritus...
November 7, 2016: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/27819528/interferon-gamma-ifn-%C3%AE-is-elevated-in-wound-exudate-from-hidradenitis-suppurativa
#14
Anirban Banerjee, Sean McNish, Victoria K Shanmugam
Hidradenitis suppurativa (HS) is a chronic recurrent inflammatory disease of apocrine glands which affects 1-4% of young adults. The purpose of this study was to investigate inflammatory cytokines in effluent from HS lesions and to identify potential local drivers of inflammation in HS. Wound fluid specimens from HS patients (n = 8) and age-matched chronic wound patients (n = 8) were selected for analysis. The hidradenitis suppurativa score (HSS) was used to determine the extent of HS activity. Cytokine analysis was conducted using Meso Scale Discovery cytokine and proinflammatory panels...
November 7, 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27815622/-cutaneous-manifestations-of-metabolic-syndrome
#15
REVIEW
G Holzer, B Straßegger, B Volc-Platzer
BACKGROUND: Metabolic syndrome (MetS) is a cluster of risk factors which increase the risk of developing cardiovascular diseases and type II diabetes mellitus. High blood pressure, hyperglycemia, dyslipidemia, and central obesity are the main risk factors. While MetS is not a dermatological diagnosis per se, several cutaneous manifestations can serve as a clinical indicator for impending MetS and facilitate an early diagnosis and therapy in order to prevent its long-term sequelae...
December 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27799806/spotlight-on-adalimumab-in-the-treatment-of-active-moderate-to-severe-hidradenitis-suppurativa
#16
REVIEW
Christina Fotiadou, Efstratios Vakirlis, Dimitrios Ioannides
Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory skin disease that affects the hair follicles of the aprocrine gland-bearing anatomical areas of the body. It is characterized by deep painful nodules and abscesses that rupture and contribute to the formation of sinus tracks and scarring. The management of HS is based on the assessment of disease severity and a combination of medical and surgical treatment according to the European Guidelines. Adalimumab, a recombinant, fully humanized, anti-tumor necrosis factor alpha (anti-TNF-α) monoclonal antibody, is the only officially approved treatment for the management of moderate-to-severe HS...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27793450/inflammatory-bowel-disease-is-associated-with-hidradenitis-suppurativa-results-from-a-multicenter-cross-sectional-study
#17
Inge E Deckers, Farida Benhadou, Marjolein J Koldijk, Veronique Del Marmol, Barbara Horváth, Jurr Boer, Hessel H van der Zee, Errol P Prens
BACKGROUND: Hidradenitis suppurativa (HS) is often associated with inflammatory bowel disease (IBD; Crohn's disease or ulcerative colitis). However, the prevalence of IBD in HS patients is unknown. OBJECTIVE: To determine the prevalence of IBD in HS patients, and determine if patients with HS and IBD have a distinct HS phenotype. METHODS: For this multicenter, cross-sectional study, HS patients were asked during their first consultation if they had IBD...
October 25, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27792671/carbon-dioxide-laser-treatment-using-methylene-blue-assisted-sinus-tract-identification-in-hidradenitis-suppurativa
#18
Øystein Grimstad, Gísli Ingvarsson
No abstract text is available yet for this article.
November 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27784520/adalimumab-humira-%C3%A2-for-hidradenitis-suppurativa
#19
Aditya K Gupta, Maria Cernea, William Abramovits, Kimberly Dawn Vincent
No abstract text is available yet for this article.
2016: Skinmed
https://www.readbyqxmd.com/read/27755170/vulvar-perianal-and-perineal-cancer-after-hidradenitis-suppurativa-a-systematic-review-and-pooled-analysis
#20
Georgios-Marios Makris, Nikiforita Poulakaki, Aristea-Maria Papanota, Evgenia Kotsifa, Theodoros N Sergentanis, Theodora Psaltopoulou
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory disease that frequently involves the perineal and perianal regions. The association between HS and malignant transformation is a rare but under recognized phenomenon. OBJECTIVE: This systematic review aims to summarize all available cases of vulvar and perianal/perineal cancer emerging in patients with HS, describing clinical and therapeutic particularities of these coexisting conditions in female patients...
October 13, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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