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hidradenitis suppurativa

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https://www.readbyqxmd.com/read/28796920/recommendations-for-the-management-of-comorbidity-in-hidradenitis-suppurativa
#1
E Dauden, P Lazaro, M D Aguilar, A J Blasco, C Suarez, I Marin, R Queiro, J Bassas-Vila, A Martorell, J García-Campayo
BACKGROUND: The association between hidradenitis suppurativa (HS) and some diseases is becoming relevant in recent years. Providing appropriate management of HS from an early stage requires to include prompt diagnosis and treatment of concomitant diseases and to prevent any potential comorbidity. This approach should consider the adverse events of the drugs used to treat HS potentially related to the onset of a comorbidity. OBJECTIVE: To provide the dermatologist with an accurate, easily used tool that will inform the diagnosis of HS comorbidity, and to facilitate decision-making regarding the referral and treatment of patient with HS-associated comorbidity...
August 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28796910/factors-predicting-the-self-evaluated-health-of-hidradenitis-suppurativa-patients-recruited-from-an-outpatient-clinic
#2
R Kjaersgaard Andersen, P Theut Riis, G B E Jemec
OBJECTIVES: In recent years, Hidradenitis suppurativa has received increased attention, but still lack well-defined, robust patient reported outcome measures. Such measures are likely to be influenced by contextual factors. We therefore aim to describe the association of biological and other factors with HS patient's self-evaluated health as reflected by the EQ5D VAS score. METHODS: This cross-sectional study measured basic information, Dermatology Life Quality Index, Major Depression Inventory, and Euro-QoL-5D...
August 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28794864/hidradenitis-suppurativa-an-update-on-connecting-the-tracts
#3
REVIEW
Mallory K Smith, Cynthia L Nicholson, Angela Parks-Miller, Iltefat H Hamzavi
Hidradenitis suppurativa (HS) is a devastating disease involving abscesses, sinus tracts, and inflammation classically affecting the axilla, groin, and/or anogenital region. Although the disease pathogenesis is not fully understood, recent advances suggest that HS pathology runs much deeper than the cutaneous manifestations. It is now believed that HS is a systemic inflammatory disease that gives rise to the characteristic cutaneous manifestations. This disease is problematic for both patients and physicians to manage because of a variety of diagnostic and management difficulties...
2017: F1000Research
https://www.readbyqxmd.com/read/28791681/hidradenitis-suppurativa-a-neglected-disease-in-indigenous-australians
#4
Dunja Ana Vekic, Jane Woods, Geoffrey D Cains
We report the first case series of hidradenitis suppurativa in patients of Indigenous Australian heritage. The incidence and ethnicity of populations affected by this condition are not known. The high comorbid disease burden and socioeconomic disadvantage that is well recognised in the Indigenous Australian population poses significant challenges to therapeutic outcomes.
August 9, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28769536/the-clinical-significance-of-increased-serum-proinflammatory-cytokines-c-reactive-protein-and-erythrocyte-sedimentation-rate-in-patients-with-hidradenitis-suppurativa
#5
D Jiménez-Gallo, R de la Varga-Martínez, L Ossorio-García, C Albarrán-Planelles, C Rodríguez, M Linares-Barrios
OBJECTIVES: To assess inflammatory serum markers including serum proinflammatory cytokines, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) according to the clinical inflammatory activity of patients with hidradenitis suppurativa (HS). PATIENTS AND METHODS: Seventy-four patients with HS were studied based on the Hidradenitis Suppurativa-Physician Global Assessment (HS-PGA) score and Hurley staging system. Proinflammatory cytokines were measured using a multiplex cytokine assay...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28764581/skin-diseases-of-the-vulva-inflammatory-erosive-ulcerating-and-apocrine-gland-diseases-zinc-and-vitamin-deficiency-vulvodynia-and-vestibulodynia
#6
Freja Lærke Sand, Simon Francis Thomsen
Chronic, inflammatory and ulcerating mucocutaneous diseases that can affect the vulvar area are reviewed: lichen sclerosus, lichen planus, plasma cell vulvitis, complex aphthosis, Behcet's disease, pyoderma gangrenosum, metastatic Crohn's disease, dyskeratotic skin diseases (Hailey-Hailey disease and Darier's disease), autoimmune bullous diseases (mucous membrane pemphigoid and pemphigus vulgaris) and hidradenitis suppurativa. Also, vulvodynia and vestibulodynia, zinc and vitamin B deficiency are described.
August 1, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28750404/altered-global-5-hydroxymethylation-status-in-hidradenitis-suppurativa-support-for-an-epigenetic-background
#7
Schapoor Hessam, Michael Sand, Kerstin Lang, Heiko U Käfferlein, Lisa Scholl, Thilo Gambichler, Marina Skrygan, Thomas Brüning, Eggert Stockfleth, Falk G Bechara
BACKGROUND: The pathogenesis of hidradenitis suppurativa (HS), with its complex inflammatory network, is still elusive. Imbalances in DNA methylation can lead to genome destabilization and have been assumed to play a role in inflammatory diseases. Global DNA methylation and hydroxymethylation have not been studied in HS yet. OBJECTIVE: We conducted this study to investigate the global DNA methylation and hydroxymethylation status in lesional and perilesional HS skin compared to healthy controls...
July 28, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28749746/the-increasing-relevance-of-biofilms-in-common-dermatological-conditions
#8
G Kravvas, D Veitch, F Al-Niaimi
BACKGROUND: Biofilms are diverse groups of microorganisms encased in a self-produced matrix that offers protection against unfavourable conditions and antibiotics. METHODS: We performed a literature search using the MEDLINE electronic database. Only original articles published in English were considered for review. RESULTS: Biofilms have been implicated in the pathogenesis of acne, eczema, hidradenitis suppurativa, onychomycosis, miliaria, and impetigo...
July 27, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28736236/patients-with-hidradenitis-suppurativa-have-a-high-psychiatric-disease-burden-a-finnish-nationwide-registry-study
#9
Laura Huilaja, Hannu Tiri, Jari Jokelainen, Markku Timonen, Kaisa Tasanen
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of hair follicles which is associated with various comorbidities. In order further to clarify the associations between HS and psychiatric disorders, we conducted a nationwide retrospective study that included 4381 patients with HS and 39554 psoriasis and 43248 melanocytic nevi patients as controls. Patient data were obtained from the statutory Finnish Care Register for Health Care. The incidence of HS was 2.7/100,000 persons/year. At least one psychiatric diagnosis was found in 24...
July 20, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28735350/inflammatory-joint-disorders-and-neutrophilic-dermatoses-a-comprehensive-review
#10
REVIEW
Massimo Cugno, Roberta Gualtierotti, Pier Luigi Meroni, Angelo Valerio Marzano
Rheumatoid arthritis and spondyloarthritis are inflammatory joint disorders with an autoimmune pathogenesis and systemic involvement. The skin is one of the most frequently affected extraarticular sites with a number of manifestations or distinct diseases, including common conditions, such as rheumatoid nodules and psoriasis, and rare diseases like neutrophilic dermatoses. The latter are clinically characterised by polymorphic lesions, including pustules, bullae, abscesses, papules, nodules, plaques and ulcers, and histologically by neutrophil-rich inflammatory infiltrates...
July 22, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28730603/hidradenitis-suppurativa-in-children-treated-with-finasteride-a-case-series
#11
Fernando Mota, Susana Machado, Manuela Selores
BACKGROUND: Hidradenitis suppurativa (HS) is rare in childhood, with only 2% of cases in patients younger than 11 years. It is a chronic, recurrent, debilitating condition for which no universally effective treatment has been developed. We present five cases of children with HS diagnosed between the ages of 6 and 11 years. METHODS: Patients were treated with oral finasteride 1 to 5 mg/day. All had entered puberty at the time of treatment initiation. All had normal laboratory results before starting treatment...
July 20, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28722455/-hidradenitis-suppurativa-symptoms-diagnostics-and-therapy
#12
Monika Arenbergerová, Robert Artur Dahmen, Petr Arenberger
Hidradenitis suppurativa is a chronic skin disorder characterized by recurrent inflammatory nodules, fistulas, abscesses, and scarring mainly in the intertriginous areas with terminal hair and apocrine glands. Hidradenitis suppurativa manifests usually after puberty, in the third life decade and persists for many years. The prevalence of the disease is estimated to be 0,5 % in the Czech Republic. Women are most often affected in the axillary and inguinal parts, while men in the perianal and gluteal areas. The exact pathogenesis is still unknown...
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/28718933/treatment-of-hidradenitis-suppurativa-with-rifampicin-have-we-forgotten-tuberculosis
#13
P Mendes-Bastos, R Macedo, R Duarte
Hidradenitis suppurativa (HS) is a chronic, recurrent and debilitating skin disease of the hair follicle that is accompanied by systemic inflammation. Treating HS is challenging, and therapeutic tools as diverse as topical and systemic antibiotics, biologics, intralesional steroids, surgical procedures or light and laser therapies are frequently needed. The combination of oral clindamycin and rifampicin (R+C) has been suggested as a possible treatment regimen (level of evidence III, strength of recommendation C)...
July 18, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28718895/considering-the-impact-of-pregnancy-on-the-natural-history-of-hidradenitis-suppurativa
#14
P Perng, J G Zampella, G A Okoye
Hidradenitis suppurativa (HS) is a chronic and debilitating inflammatory skin disease that disproportionately affects women of childbearing age. Yet, little has been written about the impact of pregnancy on the natural history of HS. It has been postulated that apocrine-gland activity diminishes in pregnancy, accounting for symptom remission. This article is protected by copyright. All rights reserved.
July 18, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28702973/clinical-and-histological-changes-in-hidradenitis-suppurativa-following-1064-nm-nd-yag-intralesional-laser-treatment
#15
N Zerbinati, E D'Este, L Ini, A Baruffato, V Premoli, A Calligaro, M Paulli
Hidradenitis Suppurativa (HS) is recently attracting much attention and awareness, often because it is misdiagnosed for years, restricting the therapeutic options. Moreover, this pathology arises in areas such as the inguinal region, that may cause embarrassment in young patients. Wrong diagnosis and delay in appropriate treatments lead to an exacerbation of the symptoms and a progression of the disease, which at the last stage can only be managed through extensive surgical excisions, ablation and vaporization of nodules with CO2 laser systems or aggressive chemotherapies such as anti-TNF-alpha like adalimumab (Humira®-AbbVie Inc...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28696038/recognizing-syndromic-hidradenitis-suppurativa-a-review-of-the-literature
#16
REVIEW
J Gasparic, P Theut Riis, G B Jemec
BACKGROUND: Hidradenitis suppurativa (HS) is an inflammatory skin disease causing painful inflammation and suppuration. It may occur in rare syndromes: follicular occlusion, Bazex-Dupré-Christol, Down's, KID, PAPASH, PASS, PASH, and SAPHO syndromes, as well as Dowling-Degos disease. An overview of syndromic HS may inform the search for etiological factors in HS. METHODS: Pubmed, Ovid, and Web of Science were systematically searched using "(hidradenitis OR acne invers*) AND (syndrome OR KID OR PASS OR PAPA OR PASH OR SAPHO OR bazex-dupre OR "dowling degos" OR triad OR tetrad)" and Cochrane Library using "hidradenitis OR acne invers*"...
July 11, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28683447/swiss-practice-recommendations-for-the-management-of-hidradenitis-suppurativa-acne-inversa
#17
Robert E Hunger, Emanuel Laffitte, Severin Läuchli, Carlo Mainetti, Michael Mühlstädt, Peter Schiller, Anne-Karine Lapointe, Pascale Meschberger, Alexander A Navarini
Hidradenitis suppurativa (HS) is a painful, inflammatory, debilitating skin disease with a chronic intermittent course. The central pathogenetic event seems to be the occlusion of the hair follicle. HS has a 1-year prevalence of about 1%. It typically presents after puberty with painful, deep-seated, inflamed lesions in the apocrine gland-bearing areas of the body: most commonly the axillae, inguinal, and anogenital regions. HS has a high negative impact on patients' quality of life even in patients with only limited disease burden, and the diagnosis of HS is often made with a long diagnostic delay...
July 7, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28679658/defining-targets-to-defeat-hidradenitis-suppurativa
#18
Hadar Lev-Tov
Immunological data implicates IL-17 pathway in the pathogenesis of hidradenitis suppurativa.
July 5, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28675899/serum-anticytokine-autoantibody-levels-are-not-increased-in-hidradenitis-suppurativa-a-case-control-pilot-study
#19
Peter Theut Riis, Jakob Hjorth von Stemann, Rune Kjærsgaard Andersen, Morten Bagge Hansen, Gregor B E Jemec
BACKGROUND: Hidradenitis suppurativa is a skin disease of recurrent episodes of inflammatory nodules, abscesses, and scarring of the intertriginous regions, e.g. the axillae and groin. A dysregulated immune response to one or more unknown antigens in hidradenitis suppurativa has been suggested. One hypothetical element of this dysregulation may be the functionality of the cytokines. This study examines the serum level of anticytokine autoantibodies for interleukin (IL)-1α, IL-6, IL-10, IL-17A, IL-17E, IL-17F, and interferon-α...
July 4, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28667743/hidradenitis-suppurativa-and-electrocardiographic-changes-a-cross-sectional-population-study
#20
C R Juhl, I M Miller, G B Jemec, J K Kanters, C Ellervik
BACKGROUND: Hidradenitis Suppurativa (HS) is a chronic, inflammatory skin disease, recently associated with metabolic syndrome, subclinical atherosclerosis and increased risk of cardiovascular disease. OBJECTIVES: The aim of the study was to investigate the hitherto unknown electrocardiographic changes associated with HS, which recently have been associated with significant cardiovascular burden. METHODS: Data were derived from the cross-sectional population study, The Danish General Population Study (GESUS)...
July 1, 2017: British Journal of Dermatology
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