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JOURNAL ARTICLE
Christian B Ramers, John D Scott, Bruce B Struminger
The current landscape of clinician burnout is prompting the need for our health care system to revise its approach toward complex conditions such as long coronavirus disease (COVID), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and other postinfectious fatiguing illnesses (PIFIs). We discuss our efforts here at Family Health Center of San Diego (FHCSD) to help share insight and glean perspective from clinicians who have participated in our Centers for Disease Control and Prevention (CDC)-funded 3-year continuing professional development initiative...
March 2024: Open Forum Infectious Diseases
#22
JOURNAL ARTICLE
Tarnjit Sehmbi, Alison Wearden, Sarah Peters, Kimberly Dienes
OBJECTIVES: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a long-term debilitating illness characterised by profound and persistent fatigue (JAMA: The Journal of the American Medical Association, 313, 2015, 1101). The current study aims to explore the experiences of women with ME/CFS living with their partners during the COVID-19 pandemic in the United Kingdom. DESIGN: The study adopted a qualitative design comprising semi-structured interviews with participants...
March 6, 2024: British Journal of Health Psychology
#23
REVIEW
Sarah J Annesley, Daniel Missailidis, Benjamin Heng, Elisha K Josev, Christopher W Armstrong
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic illness often triggered by an initiating acute event, mainly viral infections. The transition from acute to chronic disease remains unknown, but interest in this phenomenon has escalated since the COVID-19 pandemic and the post-COVID-19 illness, termed 'long COVID' (LC). Both ME/CFS and LC share many clinical similarities. Here, we present recent findings in ME/CFS research focussing on proposed disease pathologies shared with LC...
March 4, 2024: Trends in Molecular Medicine
#24
JOURNAL ARTICLE
Rahel Susanne König, Daniel Henry Paris, Marc Sollberger, Rea Tschopp
BACKGROUND: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating chronic disease of significant public health and clinical importance. It affects multiple systems in the body and has neuro-immunological characteristics. The disease is characterized by a prominent symptom called post-exertional malaise (PEM), as well as abnormalities in the immune-inflammatory pathways, mitochondrial dysfunctions and disturbances in neuroendocrine pathways. The purpose of this study was to evaluate the impact of ME/CFS on the mental health and secondary psychosocial manifestations of patients, as well as their coping mechanisms...
March 15, 2024: Heliyon
#25
REVIEW
Jing-Hua Wang, Yujin Choi, Jin-Seok Lee, Seung-Ju Hwang, Jiyeon Gu, Chang-Gue Son
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a heterogeneous disorder with elusive causes, but most likely because of clinical and other biological factors. As a vital environmental factor, the gut microbiome is increasingly emphasized in various refractory diseases including ME/CFS. The present study is aimed to enhance our understanding of the relationship between the gut microbiome and ME/CFS through data analysis of various clinical studies. We conducted a literature search in four databases (PubMed, Cochrane Library, Web of Science, and Google Scholar) until May 31, 2023...
March 1, 2024: European Journal of Medical Research
#26
JOURNAL ARTICLE
Daisy M Gaunt, Amberly Brigden, Shaun R S Harris, William Hollingworth, Russell Jago, Emma Solomon-Moore, Lucy Beasant, Nicola Mills, Parisa Sinai, Esther Crawley, Chris Metcalfe
The MAGENTA pragmatic parallel groups randomized controlled trial compared graded exercise therapy (GET) with activity management (AM) in treating paediatric myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS). Children aged 8-17 years with mild/moderate ME/CFS and presenting to NHS specialist paediatric services were allocated at random to either individualised flexible treatment focussing on physical activity (GET, 123 participants) or on managing cognitive, school and social activity (AM, 118 participants) delivered by NHS therapists...
March 2, 2024: European Journal of Pediatrics
#27
REVIEW
Peter Walter Barry, Kate Kelley, Toni Tan, Ilora Finlay
In 2021, the National Institute for Health and Care Excellence produced an evidence-based guideline on the diagnosis and management of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a disabling long-term condition of unknown cause. The guideline provides clear support for people living with ME/CFS, their families and carers, and for clinicians. A recent opinion piece published in the journal suggested that there were anomalies in the processing and interpretation of the evidence when developing the guideline and proposed eight areas where these anomalies were thought to have occurred...
February 28, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#28
JOURNAL ARTICLE
Barbara Hochecker, Noah Molinski, Katja Matt, Alica Meßmer, Melanie Scherer, Alexander von Ardenne, Jörg Bergemann
Heat treatment or hyperthermia is a promising therapy for many diseases, especially cancer, and can be traced back thousands of years. Despite its long history, little is known about the cellular and molecular effects of heat on human cells. Therefore, we investigated the impact of water-filtered infrared-A (wIRA) irradiation (39 °C, 60 min) on key cellular mechanisms, namely autophagy, mitochondrial function and mRNA expression, in human fibroblasts and peripheral blood mononuclear cells (PBMCs) from healthy donors and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) patients...
February 21, 2024: Journal of Thermal Biology
#29
JOURNAL ARTICLE
Quan M Vu, Annette L Fitzpatrick, Jennifer R Cope, Jeanne Bertolli, Nona Sotoodehnia, T Eoin West, Nikki Gentile, Elizabeth R Unger
This study aimed to estimate the incidence rates of post-COVID-19 fatigue and chronic fatigue and to quantify the additional incident fatigue caused by COVID-19. We analyzed electronic health records data of 4,589 patients with confirmed COVID-19 during February 2020-February 2021 who were followed for a median of 11.4 (interquartile range 7.8-15.5) months and compared them to data from 9,022 propensity score-matched non-COVID-19 controls. Among COVID-19 patients (15% hospitalized for acute COVID-19), the incidence rate of fatigue was 10...
March 2024: Emerging Infectious Diseases
#30
JOURNAL ARTICLE
Abdullah S AlAmri, Foziah J AlShamrani, Noor M AlMohish, Azra S Zafar, Saud A Alnaaim, Hatem A Alazman, Ibrahim A Al-Ghanimi, Abdullah A AlNahdi, Fahad A AlDawsari, Shahad B AlMatrafi, Ghaida R Alzahrani, Muna S Alnamlah, Rawan A Alkhalifa
BACKGROUND: Multiple sclerosis (MS) is a chronic, inflammatory demyelinating disease that affects various parts of the central nervous system. Fatigue, a common symptom, transient, prolonged, or chronic experienced by individuals with MS, can significantly impact daily functioning. It can be associated with underlying pathological processes or can have an idiopathic cause, such as chronic fatigue syndrome (CFS). The study aimed to assess the presence and etiology of fatigue in MS patients and its relationship with CFS...
2024: Journal of Family & Community Medicine
#31
Ito Hirobumi
A case of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) with chronic epipharyngitis was treated with epipharyngeal abrasive therapy (EAT). The symptoms of ME/CFS improved along with the improvement of chronic epipharyngitis. The patient was followed up with endocrine and autonomic function tests. Endocrine function tests included salivary cortisol and salivary α-amylase activity. Salivary α-amylase activity was stimulated by EAT. EAT improved the diurnal variability of salivary cortisol secretion...
February 2024: Curēus
#32
JOURNAL ARTICLE
Alexandra J Bratty
Chronic conditions, sometimes referred to as functional somatic disorders, such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), and more recently, long COVID (LC), affect millions of people worldwide. Yet, after decades of research and testing, the etiology and treatment for many of these diseases is still unclear. Recently, a consortium of clinicians and researchers have proposed that while many different chronic conditions exist, the root cause of each may be a similar brain-body connection, as the brain responds to perceived biological threats and transmits danger signals to the body that manifest as somatic symptoms...
January 2024: Integrative Medicine
#33
JOURNAL ARTICLE
Nilihan E M Sanal-Hayes, Lawrence D Hayes, Marie Mclaughlin, Ethan C J Berry, Nicholas F Sculthorpe
PURPOSE: Dexterity and bimanual coordination had not previously been compared between people with long COVID and people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Therefore, this study determined dexterity and bimanual coordination in people with long COVID (∼16 month illness duration; n=21) and ME/CFS (∼16 year illness duration; n=20), versus age-matched healthy controls (n=20). METHODS: Dexterity, and bimanual coordination was determined using the Purdue pegboard test...
February 23, 2024: American Journal of Medicine
#34
REVIEW
Siqi Liu, Mengli Zhong, Hao Wu, Weiwei Su, Yonggang Wang, Peibo Li
Coronavirus disease 2019 (COVID-19) caused a severe epidemic due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Recent studies have found that patients do not completely recover from acute infections, but instead, suffer from a variety of post-acute sequelae of SARS-CoV-2 infection, known as long COVID. The effects of long COVID can be far-reaching, with a duration of up to six months and a range of symptoms such as cognitive dysfunction, immune dysregulation, microbiota dysbiosis, myalgic encephalomyelitis/chronic fatigue syndrome, myocarditis, pulmonary fibrosis, cough, diabetes, pain, reproductive dysfunction, and thrombus formation...
February 4, 2024: Microorganisms
#35
JOURNAL ARTICLE
Klaus Josef Wirth, Matthias Löhn
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a frequent, debilitating and still enigmatic disease. There is a broad overlap in the symptomatology of ME/CFS and the Post-COVID-19 Syndrome (PCS). A fraction of the PCS patients develop the full clinical picture of ME/CFS. New observations in microvessels and blood from patients suffering from PCS have appeared and include microclots and malformed pathological blood cells. Capillary blood flow is impaired not only by pathological blood components but also by prothrombotic changes in the vascular wall, endothelial dysfunction, and the expression of adhesion molecules in the capillaries...
January 23, 2024: Medicina
#36
REVIEW
Brittany L Adler, Tae Chung, Peter C Rowe, John Aucott
Dysautonomia, or dysfunction of the autonomic nervous system (ANS), may occur following an infectious insult and can result in a variety of debilitating, widespread, and often poorly recognized symptoms. Dysautonomia is now widely accepted as a complication of COVID-19 and is an important component of Post-Acute Sequelae of COVID-19 (PASC or long COVID). PASC shares many overlapping clinical features with other infection-associated chronic illnesses including Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Post-Treatment Lyme Disease Syndrome (PTLDS), suggesting that they may share common underlying mechanisms including autonomic dysfunction...
2024: Frontiers in Neurology
#37
MULTICENTER STUDY
Merel E B Cornelissen, Lizan D Bloemsma, Anouk W Vaes, Nadia Baalbaki, Qichen Deng, Rosanne J H C G Beijers, Lieke C E Noij, Laura Houweling, Somayeh Bazdar, Martijn A Spruit, Anke H Maitland-van der Zee
BACKGROUND: In the Netherlands, the prevalence of post COVID-19 condition is estimated at 12.7% at 90-150 days after SARS-CoV-2 infection. This study aimed to determine the occurrence of fatigue and other symptoms, to assess how many patients meet the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) criteria, to identify symptom-based clusters within the P4O2 COVID-19 cohort and to compare these clusters with clusters in a ME/CFS cohort. METHODS: In this multicentre, prospective, observational cohort in the Netherlands, 95 post COVID-19 patients aged 40-65 years were included...
February 21, 2024: Journal of Translational Medicine
#38
JOURNAL ARTICLE
Brian Walitt, Komudi Singh, Samuel R LaMunion, Mark Hallett, Steve Jacobson, Kong Chen, Yoshimi Enose-Akahata, Richard Apps, Jennifer J Barb, Patrick Bedard, Robert J Brychta, Ashura Williams Buckley, Peter D Burbelo, Brice Calco, Brianna Cathay, Li Chen, Snigdha Chigurupati, Jinguo Chen, Foo Cheung, Lisa M K Chin, Benjamin W Coleman, Amber B Courville, Madeleine S Deming, Bart Drinkard, Li Rebekah Feng, Luigi Ferrucci, Scott A Gabel, Angelique Gavin, David S Goldstein, Shahin Hassanzadeh, Sean C Horan, Silvina G Horovitz, Kory R Johnson, Anita Jones Govan, Kristine M Knutson, Joy D Kreskow, Mark Levin, Jonathan J Lyons, Nicholas Madian, Nasir Malik, Andrew L Mammen, John A McCulloch, Patrick M McGurrin, Joshua D Milner, Ruin Moaddel, Geoffrey A Mueller, Amrita Mukherjee, Sandra Muñoz-Braceras, Gina Norato, Katherine Pak, Iago Pinal-Fernandez, Traian Popa, Lauren B Reoma, Michael N Sack, Farinaz Safavi, Leorey N Saligan, Brian A Sellers, Stephen Sinclair, Bryan Smith, Joseph Snow, Stacey Solin, Barbara J Stussman, Giorgio Trinchieri, Sara A Turner, C Stephenie Vetter, Felipe Vial, Carlotta Vizioli, Ashley Williams, Shanna B Yang, Avindra Nath
Post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) is a disabling disorder, yet the clinical phenotype is poorly defined, the pathophysiology is unknown, and no disease-modifying treatments are available. We used rigorous criteria to recruit PI-ME/CFS participants with matched controls to conduct deep phenotyping. Among the many physical and cognitive complaints, one defining feature of PI-ME/CFS was an alteration of effort preference, rather than physical or central fatigue, due to dysfunction of integrative brain regions potentially associated with central catechol pathway dysregulation, with consequences on autonomic functioning and physical conditioning...
February 21, 2024: Nature Communications
#39
REVIEW
Maria Kleinstäuber, Andreas Schröder, Sarah Daehler, Karen Johanne Pallesen, Charlotte U Rask, Mathias Sanyer, Omer Van den Bergh, Marie Weinreich Petersen, Judith G M Rosmalen
BACKGROUND: This umbrella review systematically assesses the variety and relative dominance of current aetiological views within the scientific literature for the three most investigated symptom-defined functional somatic syndromes (FSS) and their classificatory analogues within psychiatry and psychology. METHOD: An umbrella review of narrative and systematic reviews with and without meta-analyses based on a search of electronic databases (PubMed, Web of Science, Embase, PsychINFO) was conducted...
September 2023: Clin Psychol Eur
#40
JOURNAL ARTICLE
Barbara Stussman, Brice Calco, Gina Norato, Angelique Gavin, Snigdha Chigurupati, Avindra Nath, Brian Walitt
BACKGROUND: A central feature of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is post-exertional malaise (PEM), which is an acute worsening of symptoms after a physical, emotional and/or mental exertion. Dynamic measures of PEM have historically included scaled questionnaires, which have not been validated in ME/CFS. To enhance our understanding of PEM and how best to measure it, we conducted semistructured qualitative interviews (QIs) at the same intervals as visual analogue scale (VAS) measures after a cardiopulmonary exercise test (CPET)...
2024: BMJ neurology open
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