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https://www.readbyqxmd.com/read/29235992/avoiding-neuromuscular-stimulation-in-liver-irreversible-electroporation-using-radiofrequency-electric-fields
#1
Quim Castellví, Borja Mercadal, Xavier Moll, Dolors Fondevila, Anna Andaluz, Antoni Ivorra
Electroporation based treatments typically consist in applying high voltage dc pulses. As an undesired side effect, these dc pulses cause electrical stimulation of excitable tissues such as motor nerves. In the present in vivo study, it was explored the use of bursts of sinusoidal voltage in the frequency range from 50 kHz to 2 MHz to induce irreversible electroporation (IRE) whilst avoiding neuromuscular stimulation. Series of 100 dc pulses or sinusoidal bursts, both with an individual duration of 100 µs, were delivered to rabbit liver through thin needles in a monopolar electrode configuration and thoracic movements were recorded with an accelerometer...
December 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29234293/the-construction-of-self-in-relationships-narratives-and-references-to-mental-states-during-picture-book-reading-interactions-between-mothers-and-children
#2
Dolores Rollo, Emiddia Longobardi, Pietro Spataro, Francesco Sulla
Previous studies showed that mothers vary in the way in which they discuss past experiences with their children, since they can exhibit narrative (elaborative) or paradigmatic (repetitive) styles to different extents. Given this background, the aim of the present study was to analyze differences in the mothers' use of narrative styles and mental state language (MSL), as a function of children's age and gender. Thirty dyads consisting of mothers and their 4- to 6-year-old children were observed during a picture-book reading interaction...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29233514/terms-concepts-and-definitions-in-clinical-artificial-nutrition-the-cont-seen-project
#3
María Dolores Del Olmo García, Julia Ocón Bretón, Julia Álvarez Hernández, María Dolores Ballesteros Pomar, Francisco Botella Romero, Irene Bretón Lesmes, Daniel de Luis Román, Luis Miguel Luengo Pérez, Miguel Ángel Martínez Olmos, Gabriel Olveira Fuster
BACKGROUND: Imprecision in terms used in the field of clinical nutrition may lead to misinterpretations among professionals. OBJECTIVE: For this reason, the Spanish Society of Endocrinology and Nutrition (SEEN) promoted this document on the terms and definitions used in clinical artificial nutrition (enteral and parenteral), establishing an agreement between Spanish experts of this specialty. METHODS: Forty-seven specialists in endocrinology and nutrition, members of the Nutrition Area of the SEEN, participated between April and September 2016...
December 7, 2017: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29231887/real-time-monitoring-in-home-based-cardiac-rehabilitation-using-wrist-worn-heart-rate-devices
#4
Javier Medina Quero, María Rosa Fernández Olmo, María Dolores Peláez Aguilera, Macarena Espinilla Estévez
Cardiac rehabilitation is a key program which significantly reduces the mortality in at-risk patients with ischemic heart disease; however, there is a lack of accessibility to these programs in health centers. To resolve this issue, home-based programs for cardiac rehabilitation have arisen as a potential solution. In this work, we present an approach based on a new generation of wrist-worn devices which have improved the quality of heart rate sensors and applications. Real-time monitoring of rehabilitation sessions based on high-quality clinical guidelines is embedded in a wearable application...
December 12, 2017: Sensors
https://www.readbyqxmd.com/read/29230269/extracellular-vesicles-from-adipose-derived-mesenchymal-stem-cells-downregulate-senescence-features-in-osteoarthritic-osteoblasts
#5
Miguel Tofiño-Vian, Maria Isabel Guillén, María Dolores Pérez Del Caz, Miguel Angel Castejón, Maria José Alcaraz
Osteoarthritis (OA) affects all articular tissues leading to pain and disability. The dysregulation of bone metabolism may contribute to the progression of this condition. Adipose-derived mesenchymal stem cells (ASC) are attractive candidates in the search of novel strategies for OA treatment and exert anti-inflammatory and cytoprotective effects on cartilage. Chronic inflammation in OA is a relevant factor in the development of cellular senescence and joint degradation. In this study, we extend our previous observations of ASC paracrine effects to study the influence of conditioned medium and extracellular vesicles from ASC on senescence induced by inflammatory stress in OA osteoblasts...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29229638/sequencing-of-fks-hot-spot1-from-saprochaete-capitata-searching-for-a-relationship-with-reduced-echinocandin-susceptibility
#6
Inés Arrieta-Aguirre, Pilar Menéndez-Manjón, María Soledad Cuétara, Iñigo Fernández de Larrinoa, Juan Carlos García-Ruiz, María Dolores Moragues
Saprochaete capitata, formerly known as Geotrichum capitatum, is an emerging fungal pathogen with low susceptibility to echinocandins. Here, we report the nucleotide sequence of the S. capitata Hot Spot 1 region of the FKS gene (FKS HS1) which codifies for the catalytic subunit of β-1,3-D-glucan synthase, the target of echinocandins. For that purpose, we firstly designed degenerated oligonucleotide primers derived from conserved flanking regions of the FKS1 HS1 segment of 12 different fungal species. Interestingly, the analysis of the translated FKS HS1 sequences of 12 isolates of S...
December 11, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29228177/poly-3-hydroxybutyrate-hyperproduction-by-a-global-nitrogen-regulator-ntrb-mutant-strain-of-paracoccus-denitrificans-pd1222
#7
Alfonso Olaya-Abril, Víctor M Luque-Almagro, Isabel Manso, Andrew J Gates, Conrado Moreno-Vivián, David J Richardson, María Dolores Roldán
Paracoccus denitrificans PD1222 accumulates short-length polyhydroxyalkanoates, poly(3-hydroxybutyrate), under nitrogen deficient conditions. Polyhydroxybutyrate metabolism requires the 3-ketoacyl-CoA thiolase PhaA, the acetoacetyl-CoA dehydrogenase/reductase PhaB, and the synthase PhaC for polymerization. Additionally, P. denitrificans PD1222 grows aerobically with nitrate as sole nitrogen source. Nitrate assimilation is controlled negatively by ammonium through the two-component NtrBC system. NtrB is a sensor kinase that autophosphorylates a histidine residue under low nitrogen concentrations and, in turn transfers a phosphoryl group to an aspartate residue of the response regulator NtrC protein, which acts as a transcriptional activator of the P...
December 6, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29227743/the-impact-of-latino-values-and-cultural-beliefs-on-brain-donation-results-of-a-pilot-study-to-develop-culturally-appropriate-materials-and-methods-to-increase-rates-of-brain-donation-in-this-under-studied-patient-group
#8
Ann Choryan Bilbrey, Marika B Humber, Edward D Plowey, Iliana Garcia, Lakshmi Chennapragada, Kanchi Desai, Allyson Rosen, Nusha Askari, Dolores Gallagher-Thompson
OBJECTIVES: Increasing the number of Latino persons with dementia who consent to brain donation (BD) upon death is an important public health goal that has not yet been realized. This study identified the need for culturally sensitive materials to answer questions and support the decision-making process for the family. METHODS: Information about existing rates of BD was obtained from the Alzheimer's Disease Centers. Several methods of data collection (query NACC database, contacting Centers, focus groups, online survey, assessing current protocol and materials) were used to give the needed background to create culturally appropriate BD materials...
September 15, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/29226391/experience-with-leflunomide-as-treatment-and-as-secondary-prophylaxis-for-cytomegalovirus-infection-in-lung-transplant-recipients-a-case-series-and-review-of-the-literature
#9
Jose Tiago Silva, Virginia Pérez-González, Francisco López-Medrano, Rodrigo Alonso-Moralejo, Mario Fernández-Ruiz, Rafael San-Juan, Patricia Brañas, María Dolores Folgueira, José María Aguado, Alicia de Pablo-Gafas
Data concerning the use of leflunomide -a drug approved for rheumatoid arthritis with in vitro anti-cytomegalovirus (CMV) activity- in lung transplant (LT) recipients are scarce. We performed a single center retrospective study including LT recipients who received leflunomide for CMV infection or as secondary prophylaxis after viremia clearance. We also conducted a full systematic PubMed search until June 30, 2017. We identified 5 LT recipients in our center, plus 7 patients reported in the literature. All patients had previously received ganciclovir (GCV) and foscarnet, with drug-induced adverse effects described in 6 recipients (50%)...
December 11, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29225764/sodium-chloride-accumulation-in-glycophyte-plants-with-cyanobacterial-symbionts
#10
Thomas George Allan Green, Leopoldo G Sancho, Ana Pintado, Dolores Saco, Soledad Martín, María Arróniz-Crespo, Miguel Angel Casermeiro, Maria Teresa de la Cruz Caravaca, Steven Cameron, Ricardo Rozzi
The majority of plant species are glycophytes and are not salt-tolerant and maintain low sodium levels within their tissues; if. high tissue sodium concentrations do occur, it is in response to elevated environmental salt levels. Here we report an apparently novel and taxonomically diverse grouping of plants that continuously maintain high tissue sodium contents and share the rare feature of possessing symbiotic cyanobacteria. Leaves of Gunnera magellanica in Tierra del Fuego always had sodium contents (dry weight basis) of around 4...
November 2017: AoB Plants
https://www.readbyqxmd.com/read/29225024/at-birth-humans-associate-few-with-left-and-many-with-right
#11
Maria Dolores de Hevia, Ludovica Veggiotti, Arlette Streri, Cory D Bonn
Humans use spatial representations to structure abstract concepts [1]. One of the most well-known examples is the "mental number line"-the propensity to imagine numbers oriented in space [2, 3]. Human infants [4, 5], children [6, 7], adults [8], and nonhuman animals [9, 10] associate small numbers with the left side of space and large numbers with the right. In humans, cultural artifacts, such as the direction of reading and writing, modulate the directionality of this representation, with right-to-left reading cultures associating small numbers with right and large numbers with left [11], whereas the opposite association permeates left-to-right reading cultures [8]...
December 1, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29221826/trends-of-invasive-pneumococcal-disease-and-its-serotypes-in-the-autonomous-community-of-madrid
#12
Pello Latasa Zamalloa, Juan Carlos Sanz Moreno, María Ordobás Gavín, María Dolores Barranco Ordoñez, Esther Insúa Marisquerena, Ángel Gil de Miguel, Abelardo Claudio Fernández Chávez, Luis García-Comas
INTRODUCTION: Streptococcus pneumoniae is an important cause of morbidity. Vaccination is the most effective measure to prevent it. The aim of this study is to analyse the evolution of invasive pneumococcal disease (IPD). MATERIAL AND METHODS: Observational study of IPD cases notified to the Epidemiological Surveillance Network of the Autonomous Community of Madrid between 2008 and 2015. The IPD case was defined as the disease caused by Streptococcus pneumoniae, with isolation and DNA or antigen detection, in samples from normally sterile sites...
December 5, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29218390/gemelli-obturator-complex-in-the-deep-gluteal-space-an-anatomic-and-dynamic-study
#13
Ramon Balius, Antonio Susín, Carles Morros, Montse Pujol, Dolores Pérez-Cuenca, Xavier Sala-Blanch
OBJECTIVE: To investigate the behavior of the sciatic nerve during hip rotation at subgluteal space. MATERIALS AND METHODS: Sonographic examination (high-resolution ultrasound machine at 5.0-14 MHZ) of the gemelli-obturator internus complex following two approaches: (1) a study on cadavers and (2) a study on healthy volunteers. The cadavers were examined in pronation, pelvis-fixed position by forcing internal and external rotations of the hip with the knee in 90° flexion...
December 7, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/29217115/-psychosomatic-symptoms-as-an-expression-of-the-deterioration-of-the-health-related-quality-of-life-in-adolescents
#14
Rosa M Fuentes Chacón, M José Simón Saiz, Margarita Garrido Abejar, M Dolores Serrano Parra, M Elisa Larrañaga Rubio, Santiago Yubero Jiménez
AIM: To analyze, in a population of adolescents in school, the relationship between psychosomatic symptoms and the perception of health-related quality of life (HRQoL), differentiating by gender and age group. DESIGN: Transversal study. LOCATION: Five Secondary Schools. PARTICIPANTS: Eight hundred and forty four adolescents between the ages of 15 and 18 in secondary school. MAIN MEASUREMENTS: HRQoL using KIDSCREEN-52 and psychosomatic symptoms with the psychosomatic problems scale (PSP)...
December 4, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/29214587/rare-neurodegenerative-diseases-clinical-and-genetic-update
#15
Antoni Matilla-Dueñas, Marc Corral-Juan, Agustí Rodríguez-Palmero Seuma, Dolores Vilas, Lourdes Ispierto, Sara Morais, Jorge Sequeiros, Isabel Alonso, Víctor Volpini, Carmen Serrano-Munuera, Guillem Pintos-Morell, Ramiro Álvarez, Ivelisse Sánchez
More than 600 human disorders afflict the nervous system. Of these, neurodegenerative diseases are usually characterised by onset in late adulthood, progressive clinical course, and neuronal loss with regional specificity in the central nervous system. They include Alzheimer's disease and other less frequent dementias, brain cancer, degenerative nerve diseases, encephalitis, epilepsy, genetic brain disorders, head and brain malformations, hydrocephalus, stroke, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis (ALS or Lou Gehrig's Disease), Huntington's disease, and Prion diseases, among others...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29214548/first-clinical-symptom-as-a-prognostic-factor-in-systemic-sclerosis-results-of-a-retrospective-nationwide-cohort-study
#16
Manuel Rubio-Rivas, Xavier Corbella, Melany Pestaña-Fernández, Carles Tolosa-Vilella, Alfredo Guillen-Del Castillo, Dolores Colunga-Argüelles, Luis Trapiella-Martínez, Nerea Iniesta-Arandia, María Jesús Castillo-Palma, Luis Sáez-Comet, María Victoria Egurbide-Arberas, Norberto Ortego-Centeno, Mayka Freire, Jose Antonio Vargas-Hitos, Juan José Ríos-Blanco, Jose Antonio Todolí-Parra, Mónica Rodríguez-Carballeira, Adela Marín-Ballvé, Pablo Segovia-Alonso, Xavier Pla-Salas, Ana Belén Madroñero-Vuelta, Manuel Ruiz-Muñoz, Vicent Fonollosa-Pla, Carmen Pilar Simeón-Aznar, E Callejas Moraga, E Calvo, C Carbonell, M J Castillo, A J Chamorro, D Colunga, X Corbella, M V Egurbide, G Espinosa, V Fonollosa, M Freire, F J García Hernández, R González León, A Guillén Del Castillo, N Iniesta, R Lorenzo, A B Madroñero, B Marí, A Marín, N Ortego-Centeno, M Pérez Conesa, M Pestaña, X Pla, J J Ríos Blanco, M Rodríguez Carballeira, M Rubio Rivas, M Ruiz Muñoz, L Sáez Comet, P Segovia, C P Simeón, A Soto, E Tarí, J A Todolí, C Tolosa, L Trapiella, J A Vargas Hitos, G Verdejo
The objective of the study is to determine the importance of the mode of onset as prognostic factor in systemic sclerosis (SSc). Data were collected from the Spanish Scleroderma Registry (RESCLE), a nationwide retrospective multicenter database created in 2006. As first symptom, we included Raynaud's phenomenon (RP), cutaneous sclerosis, arthralgia/arthritis, puffy hands, interstitial lung disease (ILD), pulmonary arterial hypertension (PAH), and digestive hypomotility. A total of 1625 patients were recruited...
December 7, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29214019/pkm2-is-not-required-for-colon-cancer-initiated-by-apc-loss
#17
Allison N Lau, William J Israelsen, Jatin Roper, Mark J Sinnamon, Larissa Georgeon, Talya L Dayton, Alissandra L Hillis, Omer H Yilmaz, Dolores Di Vizio, Kenneth E Hung, Matthew G Vander Heiden
Background: Cancer cells express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2). PKM2 expression is not required for some cancers, and PKM2 loss can promote cancer progression; however, PKM2 has been reported to be essential in other tumor contexts, including a proposed non-metabolic role in β-catenin nuclear translocation. PKM2 is expressed in colon cancers where loss of the Apc tumor suppressor results in β-catenin nuclear translocation and aberrant activation of the canonical Wnt signaling pathway...
2017: Cancer & Metabolism
https://www.readbyqxmd.com/read/29212700/the-alere%C3%A2-binaxnow%C3%A2-pneumococcal-urinary-antigen-test-diagnostic-sensitivity-for-adult-pneumococcal-pneumonia-and-relationship-to-specific-serotypes
#18
Hisashi Shoji, Arnau Domenech, Antonella Francesca Simonetti, Aida González, Dolores García, Meritxell Cubero, Sara Martí, Masayuki Maeda, Fe Tubau, Josefina Liñares, Maria Angeles Domínguez, Jordi Carratalà, Carmen Ardanuy
Little is known about the sensitivity of the BinaxNOW® pneumococcal urinary antigen (PUA) test for adult pneumococcal pneumonia caused by different serotypes. In this study, we aimed to analyze the trends in the sensitivity of the PUA test over a 15-year period (2001-2015), and to analyze its sensitivity for pneumococcal pneumonia caused by different serotypes. In total, we analyzed 1096 pneumococcal isolates from adults with pneumococcal pneumonia that had a PUA test performed at the onset of the episode...
December 6, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29210877/music-intervention-with-reminiscence-therapy-and-reality-orientation-for-elderly-people-with-alzheimer-disease-living-in-a-nursing-home-a-pilot-study
#19
María Dolores Onieva-Zafra, Laura Hernández-Garcia, María Teresa Gonzalez-Del-Valle, María Laura Parra-Fernández, Elia Fernandez-Martinez
The purpose of this study was to investigate the effect of an 8-week nursing intervention consisting of 2 weekly sessions of music and reminiscence therapy together with the application of reality orientation techniques. Our expectation at the onset of the study was that listening to music that was familiar and connected with the memory of past events would, due to the music's emotional impact, stimulate memory associations, leading, in turn, to a positive effect on depression and anxiety in people living with dementia...
January 2018: Holistic Nursing Practice
https://www.readbyqxmd.com/read/29209926/a-randomized-trial-of-phenylephrine-infusion-versus-bolus-dosing-for-nausea-and-vomiting-during-cesarean-delivery-in-obese-women
#20
Ronald B George, Dolores M McKeen, Jennifer E Dominguez, Terrence K Allen, Patricia A Doyle, Ashraf S Habib
PURPOSE: Hypotension is common after spinal anesthesia for Cesarean delivery. It is associated with nausea, vomiting, and fetal acidosis. Previous research on phenylephrine excluded obese subjects. We compared the incidence of intraoperative nausea and vomiting (IONV) in obese patients who received a prophylactic phenylephrine infusion vs those who received bolus dosing for the treatment of spinal-induced hypotension. METHODS: In this multicentre, double-blinded randomized controlled trial, 160 obese women undergoing elective Cesarean delivery under spinal anesthesia were randomized to receive a prophylactic phenylephrine infusion initiated at 50 μg·min-1 (and titrated according to a predefined algorithm) or 100 μg phenylephrine boluses to treat hypotension...
December 5, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
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