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https://www.readbyqxmd.com/read/28435771/brown-adipose-tissue-bioenergetics-a-new-methodological-approach
#1
María Calderon-Dominguez, Martín Alcalá, David Sebastián, Antonio Zorzano, Marta Viana, Dolors Serra, Laura Herrero
The rediscovery of brown adipose tissue (BAT) in humans and its capacity to oxidize fat and dissipate energy as heat has put the spotlight on its potential as a therapeutic target in the treatment of several metabolic conditions including obesity and diabetes. To date the measurement of bioenergetics parameters has required the use of cultured cells or extracted mitochondria with the corresponding loss of information in the tissue context. Herein, we present a method to quantify mitochondrial bioenergetics directly in BAT...
April 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28431897/failure-renal-aetiology-in-patients-with-infective-endocarditis-the-role-of-antibiotics
#2
Miguel Ángel Goenaga Sánchez, Xabier Kortajarena Urkola, Emilio Bouza Santiago, Patricia Muñoz García, Eduardo Verde Moreno, M Carmen Fariñas Álvarez, Ramón Teira Cobo, Juan Manuel Pericás Pulido, Arístides de Alarcón González, Dolores Sousa Regueiro, Josefa Ruiz Morales, Regino José Rodríguez-Álvarez, Isabel Antorrena Miranda, José Antonio Iribarren Loyarte
BACKGROUND AND OBJECTIVES: The possible renal toxicity of certain antibiotics (AB) is well known. The objective of our work is to know the possible effect of AB treatments in the development of renal failure (RF) in patients with infective endocarditis (IE). MATERIAL AND METHOD: Collection from a national multi-centre registry of collection on renal function, both prior and its impairment, if any, during the treatment of IE and in relation to possible causative factors, including the use of AB...
April 18, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28431310/characterization-of-bacterial-communities-of-donkey-milk-by-high-throughput-sequencing
#3
Maria de Los Dolores Soto Del Rio, Alessandra Dalmasso, Tiziana Civera, Maria Teresa Bottero
The interest in donkey milk (DM) is growing because of its functional properties and nutritional value, especially for children with allergies and food intolerances. However, most of the available reports of DM microbiota are based on culture-dependent methods to investigate food safety issues and the presence of lactic acid bacteria (LAB). The aim of this study was to determine the composition of DM bacterial communities using a high-throughput sequencing (HTS) approach. Bulk milk samples from Italian donkey dairy farms from two consecutive years were analysed using the MiSeq Illumina platform...
March 30, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28429897/single-nucleotide-polymorphisms-v4-and-t1-of-the-adam33-gene-in-venezuelan-patients-with-asthma-or-chronic-obstructive-pulmonary-disease
#4
Daniela Martínez, Diego Lema, Dolores Del Carmen Moreno, Alexis Hipólito García, Jenny Valentina Garmendia, Juan Bautista De Sanctis
ADAM33 is a metalloproteinase important in the extracellular matrix for tissue remodeling, and, consequently, in asthma and chronic obstructive pulmonary disease (COPD). Several polymorphisms of the ADAM33 gene have been associated with enzyme activity. One of the most studied polymorphisms is V4, cytosine for guanine in the 3 'UTR region, and T1, adenine for guanine in the exon 19 of the gen. The aim of this study was to ascertain the possible association among single polymorphisms of ADAM33, V4 and T1, in Venezuelan patients with asthma or COPD...
June 2016: Investigación Clínica
https://www.readbyqxmd.com/read/28429300/agroecology-and-health-lessons-from-indigenous-populations
#5
REVIEW
José Suárez-Torres, José Ricardo Suárez-López, Dolores López-Paredes, Hilario Morocho, Luis Enrique Cachiguango-Cachiguango, William Dellai
PURPOSE OF REVIEW: The article aims to systematize and disseminate the main contributions of indigenous ancestral wisdom in the agroecological production of food, especially in Latin America. For this purpose, it is necessary to ask whether such knowledge can be accepted by academia research groups and international forums as a valid alternative that could contribute to overcome the world's nutritional problems. RECENT FINDINGS: Although no new findings are being made, the validity of ancestral knowledge and agroecology is recognized by scientific research, and by international forums organized by agencies of the United Nations...
April 20, 2017: Current Environmental Health Reports
https://www.readbyqxmd.com/read/28427797/spectrum-of-alpha-1-antitripsin-deficiency-mutations-detected-in-tenerife
#6
Francisco Martínez Bugallo, Juan Marco Figueira Gonçalves, María Dolores Martín Martínez, David Díaz Pérez
No abstract text is available yet for this article.
April 17, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28426350/lenalidomide-maintenance-compared-with-placebo-in-responding-elderly-patients-with-diffuse-large-b-cell-lymphoma-treated-with-first-line-rituximab-plus-cyclophosphamide-doxorubicin-vincristine-and-prednisone
#7
Catherine Thieblemont, Hervé Tilly, Maria Gomes da Silva, Rene-Olivier Casasnovas, Christophe Fruchart, Franck Morschhauser, Corinne Haioun, Julien Lazarovici, Anida Grosicka, Aurore Perrot, Judith Trotman, Catherine Sebban, Dolores Caballero, Richard Greil, Koen van Eygen, Amos M Cohen, Hugo Gonzalez, Reda Bouabdallah, Lucie Oberic, Bernadette Corront, Bachra Choufi, Armando Lopez-Guillermo, John Catalano, Achiel Van Hoof, Josette Briere, Jose Cabeçadas, Gilles Salles, Philippe Gaulard, Andre Bosly, Bertrand Coiffier
Purpose The standard treatment of patients with diffuse large B-cell lymphoma (DLBCL) is rituximab in combination with cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). Lenalidomide, an immunomodulatory agent, has shown activity in DLBCL. This randomized phase III trial compared lenalidomide as maintenance therapy with placebo in elderly patients with DLBCL who achieved a complete response (CR) or partial response (PR) to R-CHOP induction. Methods Patients with previously untreated DLBCL or other aggressive B-cell lymphoma were 60 to 80 years old, had CR or PR after six or eight cycles of R-CHOP, and were randomly assigned to lenalidomide maintenance 25 mg/d or placebo for 21 days of every 28-day cycle for 24 months...
April 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28425974/on-the-edge-of-research-and-technological-application-a-critical-review-of-electromethanogenesis
#8
REVIEW
Ramiro Blasco-Gómez, Pau Batlle-Vilanova, Marianna Villano, Maria Dolors Balaguer, Jesús Colprim, Sebastià Puig
The conversion of electrical current into methane (electromethanogenesis) by microbes represents one of the most promising applications of bioelectrochemical systems (BES). Electromethanogenesis provides a novel approach to waste treatment, carbon dioxide fixation and renewable energy storage into a chemically stable compound, such as methane. This has become an important area of research since it was first described, attracting different research groups worldwide. Basics of the process such as microorganisms involved and main reactions are now much better understood, and recent advances in BES configuration and electrode materials in lab-scale enhance the interest in this technology...
April 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28424549/seasonal-variability-in-clinical-care-of-copd-outpatients-results-from-the-andalusian-copd-audit
#9
Jose Luis López-Campos, Maria Abad Arranz, Carmen Calero-Acuña, Fernando Romero-Valero, Ruth Ayerbe-García, Antonio Hidalgo-Molina, Ricardo I Aguilar-Pérez-Grovas, Francisco García-Gil, Francisco Casas-Maldonado, Laura Caballero-Ballesteros, María Sánchez-Palop, Dolores Pérez-Tejero, Alejandro Segado Soriano, Jose Calvo-Bonachera, Bárbara Hernández-Sierra, Adolfo Doménech, Macarena Arroyo-Varela, Francisco González-Vargas, Juan J Cruz-Rueda
OBJECTIVES: Clinical practice in chronic obstructive pulmonary disease (COPD) can be influenced by weather variability throughout the year. To explore the hypothesis of seasonal variability in clinical practice, the present study analyzes the results of the 2013-2014 Andalusian COPD audit with regard to changes in clinical practice according to the different seasons. METHODS: The Andalusian COPD audit was a pilot clinical project conducted from October 2013 to September 2014 in outpatient respiratory clinics of hospitals in Andalusia, Spain (8 provinces with more than 8 million inhabitants) with retrospective data gathering...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28423494/control-of-long-distance-cell-to-cell-communication-and-autophagosome-transfer-in-squamous-cell-carcinoma-via-tunneling-nanotubes
#10
Inés Sáenz-de-Santa-María, Cristóbal Bernardo-Castiñeira, Eduardo Enciso, Inmaculada García-Moreno, Jose Luis Chiara, Carlos Suarez, María-Dolores Chiara
Tunneling nanotubes (TnTs) are thin channels that temporally connect nearby cells allowing the cell-to-cell trafficking of biomolecules and organelles. The presence or absence of TnTs in human neoplasms and the mechanisms of TnT assembly remains largely unexplored. In this study, we have identified TnTs in tumor cells derived from squamous cell carcinomas (SCC) cultured under bi-dimensional and tri-dimensional conditions and also in human SCC tissues. Our study demonstrates that TnTs are not specific of epithelial or mesenchymal phenotypes and allow the trafficking of endosomal/lysosomal vesicles, mitochondria, and autophagosomes between both types of cells...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423463/temperature-regulation-of-marine-heterotrophic-prokaryotes-increases-latitudinally-as-a-breach-between-bottom-up-and-top-down-controls
#11
Xosé Anxelu G Morán, Josep M Gasol, Massimo C Pernice, Jean-François Mangot, Ramon Massana, Elena Lara, Dolors Vaqué, Carlos M Duarte
Planktonic heterotrophic prokaryotes make up the largest living biomass and process most organic matter in the ocean. Determining when and where the biomass and activity of heterotrophic prokaryotes are controlled by resource availability (bottom-up), predation and viral lysis (top-down) or temperature will help in future carbon cycling predictions. We conducted an extensive survey across subtropical and tropical waters of the Atlantic, Indian and Pacific Oceans during the Malaspina 2010 Global Circumnavigation Expedition and assessed indices for these three types of controls at 109 stations (mostly from the surface to 4000 m depth)...
April 19, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28421782/lactancia-materna-para-control-del-dolor-agudo-en-lactantes-ensayo-cl%C3%A3-nico-controlado-ciego-simple
#12
Jessie Nallely Zurita-Cruz, Rodolfo Rivas-Ruiz, Virginia Gordillo-Álvarez, Miguel Ángel Villasis-Keever
Objetivo: determinar la efi cacia de la lactancia materna (LM) para el manejo del dolor agudo después de la vacunación en lactantes menores de 6 meses al compararse con el sucedáneo de la leche (SL) y no aplicar ninguna maniobra.Métodos: se realizó un ensayo clínico controlado aleatorizado, ciego simple en fase III en lactantes menores de 6 meses de edad. Se incluyeron 3 grupos: LM, SL y sin aplicar analgesia (control). El dolor se midió a través del tiempo de llanto y una escala de dolor pediátrico...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28421746/multifunctional-enzymatically-generated-hydrogels-for-chronic-wound-application
#13
Ivaylo Stefanov, Sílvia Pérez-Rafael, Javier Hoyo, Jonathan Cailloux, Orlando O Santana Perez, Dolores Hinojosa-Caballero, Tzanko Tzanov
The healing of chronic wounds requires intensive medical intervention at huge healthcare costs. Dressing materials should consider the multifactorial nature of these wounds comprising deleterious proteolytic and oxidative enzymes, and high bacterial load. In this work, multifunctional hydrogels for chronic wound application were produced by enzymatic crosslinking of thiolated chitosan and gallic acid. The hydrogels combine several beneficial to wound healing properties, controlling the matrix metalloproteinases (MMPs) and myeloperoxidase (MPO) activities, oxidative stress and bacterial contamination...
April 19, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28420367/rationale-and-methods-of-the-ifightdepression-study-a-double-blind-randomized-controlled-trial-evaluating-the-efficacy-of-an-internet-based-self-management-tool-for-moderate-to-mild-depression
#14
Azucena Justicia, Matilde Elices, Ana Isabel Cebria, Diego J Palao, Jesús Gorosabel, Dolors Puigdemont, Javier de Diego-Adeliño, Andrea Gabilondo, Alvaro Iruin, Ulrich Hegerl, Víctor Pérez
BACKGROUND: During the last decade online interventions have emerged as a promising approach for patients with mild/moderate depressive symptoms, reaching at large populations and representing cost-effective alternatives. The main objective of this double-blind, randomized controlled trial is to examine the efficacy of an internet-based self-management tool (iFightDepression) for mild to moderate depression as an add-on to treatment as usual (TAU) versus internet-based psychoeducation plus TAU...
April 19, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28419794/-healthy-workplaces-a-goal-or-a-long-distance-run
#15
EDITORIAL
Dolores Solé Gómez
No abstract text is available yet for this article.
April 2017: Archivos de Prevención de Riesgos Laborales
https://www.readbyqxmd.com/read/28419475/fruit-and-vegetable-intake-and-prostate-cancer-risk-in-the-european-prospective-investigation-into-cancer-and-nutrition-epic
#16
Aurora Perez-Cornago, Ruth C Travis, Paul N Appleby, Konstantinos K Tsilidis, Anne Tjønneland, Anja Olsen, Kim Overvad, Verena Katzke, Tilman Kühn, Antonia Trichopoulou, Eleni Peppa, Maria Kritikou, Sabina Sieri, Domenico Palli, Carlotta Sacerdote, Rosario Tumino, H Bas Bueno-de-Mesquita, Antonio Agudo, Nerea Larrañaga, Elena Molina-Portillo, Eva Ardanaz, Maria-Dolores Chirlaque, Cristina Lasheras, Pär Stattin, Maria Wennberg, Isabel Drake, Johan Malm, Julie A Schmidt, Kay-Tee Khaw, Marc Gunter, Heinz Freisling, Inge Huybrechts, Dagfinn Aune, Amanda J Cross, Elio Riboli, Timothy J Key
Several dietary factors have been studied in relation to prostate cancer; however, most studies have not reported on subtypes of fruit and vegetables or tumor characteristics, and results obtained so far are inconclusive. This study aimed to examine the prospective association of total and subtypes of fruit and vegetable intake with the incidence of prostate cancer overall, by grade and stage of disease, and prostate cancer death. Lifestyle information for 142,239 men participating in the European Prospective Investigation into Cancer and Nutrition from 8 European countries was collected at baseline...
April 17, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28419282/autologous-hematopoietic-stem-cell-transplantation-for-refractory-crohn-s-disease-efficacy-in-a-single-centre-cohort
#17
Alicia López-García, Montserrat Rovira, Aranzazu Jauregui-Amezaga, Pedro Marín, Rebeca Barastegui, Azucena Salas, Vicent Ribas, Faust Feu, J Ignasi Elizalde, Francesc Fernández-Avilés, Carmen Martínez, Gonzalo Gutiérrez, Laura Rosiñol, Enric Carreras, Alvaro Urbano, Miguel Lozano, Joan Cid, Maria Suárez-Lledó, Maria Carme Masamunt, Dolors Comas, Angel Giner, Marta Gallego, Ignacio Alfaro, Ingrid Ordás, Julian Panés, Elena Ricart
Background: Hematopoietic stem cell transplantation (HSCT) is considered a therapeutic option for patients with severe Crohn's disease (CD) unresponsive to currently available therapies. Methods: Autologous HSCT was considered for CD patients with active disease, unresponsive or intolerant to approved medications and unsuitable for surgery. After HSCT, patients were closely followed-up every 6 weeks during the first 2 years and every 6 months thereafter up to 5 years...
April 13, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28417875/influence-of-malnutrition-upon-all-cause-mortality-among-children-in-swaziland
#18
Paula Acevedo, María Teresa García Esteban, Noemí Lopez-Ejeda, Amador Gómez, María Dolores Marrodán
OBJECTIVE: To analyze the effect of the type of malnutrition, sex, age and the presence of edema upon all-cause mortality in children under 5 years of age. MATERIAL AND METHODS: A cross-sectional study was conducted during 2010 and 2011 in Swaziland. Sex, age, weight and height were taken to classify nutritional status according to the 2006 WHO growth standards: stunting (low height for age), wasting (low weight for height or low body mass index for age) and underweight (low weight for age)...
April 2017: Endocrinol Diabetes Nutr
https://www.readbyqxmd.com/read/28417514/enlarged-cavum-septi-pellucidi-and-vergae-in-the-fetus-a-cause-for-concern
#19
Yoona K Ho, Michelle Turley, Krishelle L Marc-Aurele, Marilyn C Jones, Elise Housman, Dawn Engelkemier, Lorene E Romine, Paritosh C Khanna, Dolores H Pretorius
OBJECTIVES: To investigate fetal cases identified at our institution to determine whether an enlarged cavum septi pellucidi or cavum vergae is associated with other fetal abnormalities and whether its presence warrants more detailed investigation of the fetus. METHODS: In a retrospective study, 15 high- and low-risk patients undergoing prenatal sonography who had an enlarged cavum septi pellucidi or cavum vergae identified were reviewed. Data were collected for the sonographic study indication, gestation age at diagnosis of a prominent cavum, and associated anomalies...
April 18, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28416409/-recommendations-for-the-unequivocal-identification-of-the-newborn
#20
Ester Sanz López, Manuel Sánchez Luna, Segundo Rite Gracia, Isabel Benavente Fernández, José Luis Leante Castellanos, Alejandro Pérez Muñuzuri, César W Ruiz Campillo, María Dolores Sánchez Redondo
Newborn identification is a legal right recognised by international and national laws. Moreover, improving the accuracy of correct patient identification is an important goal of patient safety solutions programs. In this article, the Standards Committee of the Spanish Society of Neonatology establishes recommendations to ensure correct identification of the newborn whilst in hospital. Currently, the most reliable method of identification of the newborn is the combination of identification cord clamp and bracelets (mother bracelet, newborn bracelet and cord clamp with the same number and identical and exclusive barcode system for each newborn) and the collection of maternal and umbilical cord blood samples (for DNA testing only for identification purposes)...
April 14, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
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