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Mercedes Rubio, Jose Luis Maestro, Maria-Dolors Piulachs, Xavier Belles
No abstract text is available yet for this article.
April 12, 2018: Biochimica et Biophysica Acta
Thais Larrainzar-Coghen, Dolors Rodríguez-Pardo, Nuria Fernández-Hidalgo, Mireia Puig-Asensio, Carles Pigrau, Carmen Ferrer, Virginia Rodríguez, Rosa Bartolomé, David Campany, Benito Almirante
OBJECTIVE: Describe secular trends in the epidemiology and outcome of Clostridium difficile infection (CDI) at a tertiary hospital. METHODS: All consecutive primary CDI episodes in adults (January 2006-December 2015) were included. CDI was diagnosed on the presence of diarrhoea and a positive stool test for C. difficile toxin A and/or B. To define trends, a time-series analysis was performed using yearly data on demographics, clinical characteristics, management, antimicrobial treatment, and outcome of CDI...
April 12, 2018: Anaerobe
Santiago Hurtado-Bermúdez, María Villa-Alfageme, José Luis Mas, María Dolores Alba
The development of Deep Geological Repositories (DGP) to the storage of high-level radioactive waste (HLRW) is mainly focused in systems of multiple barriers based on the use of clays, and particularly bentonites, as natural and engineered barriers in nuclear waste isolation due to their remarkable properties. Due to the fact that uranium is the major component of HLRW, it is required to go in depth in the analysis of the chemistry of the reaction of this element within bentonites. The determination of uranium under the conditions of HLRW, including the analysis of silicate matrices before and after the uranium-bentonite reaction, was investigated...
April 5, 2018: Applied Radiation and Isotopes
M Dolores Paredes, Paola Romecín, Noemí M Atucha, Francisco O'Valle, Julián Castillo, M Clara Ortiz, Joaquín García-Estañ
BACKGROUND: we have evaluated the antihypertensive effect of several flavonoid extracts in a rat model of arterial hypertension caused by chronic administration (6 weeks) of the nitric oxide synthesis inhibitor, L-NAME. METHODS: Sprague Dawley rats received L-NAME alone or L-NAME plus flavonoid-rich vegetal extracts (Lemon, Grapefruit + Bitter Orange, and Cocoa) or purified flavonoids (Apigenin and Diosmin) for 6 weeks. RESULTS: L-NAME treatment resulted in a marked elevation of blood pressure, and treatment with Apigenin, Lemon Extract, and Grapefruit + Bitter Orange extracts significantly reduced the elevated blood pressure of these animals...
April 13, 2018: Nutrients
A Adin, D Lee, T Goicoa, María Dolores Ugarte
Disease risk maps for areal unit data are often estimated from Poisson mixed models with local spatial smoothing, for example by incorporating random effects with a conditional autoregressive prior distribution. However, one of the limitations is that local discontinuities in the spatial pattern are not usually modelled, leading to over-smoothing of the risk maps and a masking of clusters of hot/coldspot areas. In this paper, we propose a novel two-stage approach to estimate and map disease risk in the presence of such local discontinuities and clusters...
January 1, 2018: Statistical Methods in Medical Research
María Jesús Casuso-Holgado, Rocío Martín-Valero, Ana F Carazo, Esther M Medrano-Sánchez, M Dolores Cortés-Vega, Francisco José Montero-Bancalero
OBJECTIVE: To evaluate the evidence for the use of virtual reality to treat balance and gait impairments in multiple sclerosis rehabilitation. DESIGN: Systematic review and meta-analysis of randomized controlled trials and quasi-randomized clinical trials. METHODS: An electronic search was conducted using the following databases: MEDLINE (PubMed), Physiotherapy Evidence Database (PEDro), Cochrane Database of Systematic Reviews (CDSR) and (CINHAL)...
April 1, 2018: Clinical Rehabilitation
Dolores Encinas, Zuriñe Gómez-de-Balugera
Fullerenes are emerging pollutants, and it is essential to determine and quantify these compounds to assess environmental risk and environmental flows. The goal of this work was to determine the fullerene C60 emission levels in the atmospheric aerosol and their relationship with combustion processes. To measure the concentration, a fullerene C60 extraction method with toluene was optimized in air samples using ultrasound, followed by analysis using high-pressure, liquid chromatography-diode array detector-mass spectrometry...
April 12, 2018: Archives of Environmental Contamination and Toxicology
Koleen McCrink, Maria Dolores de Hevia
No abstract text is available yet for this article.
2018: Frontiers in Psychology
Ana Herranz Barbero, Erika Sánchez Ortiz, M ª Dolors Salvia-Roigés, Rocío Cortés Albuixech, José Manuel Rodríguez-Miguélez
No abstract text is available yet for this article.
April 9, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
Vicente Merino-Bohorquez, Fernando Docobo-Pérez, Jesús Sojo, Isabel Morales, Carmen Lupión, Dolores Martín, Manuel Cameán, William Hope, Álvaro Pascual, Jesús Rodríguez-Baño
The aim of the present study was to describe the population pharmacokinetics of fosfomycin for patients with bacteraemic urinary tract infection (B-UTI). The analysis identified optimal regimens, based on pharmacodynamic targets and assessed the adequacy of CLSI and EUCAST susceptibility breakpoints for Escherchia coli. MethodsSixteen patients with B-UTI caused by multidrug-resistant E. coli, (FOREST clinical trial) received intravenous fosfomycin (4g/Q6h) were analysed. A population pharmacokinetic analysis was performed, and Monte Carlo simulations were undertaken using 4g/Q6h or 8g/Q8h...
April 9, 2018: Clinical Microbiology and Infection
Samara M A Alexandre, Maria L Corradi da Silva, Ana F D Vasconcelos, Diego T D Exposti, Cesar A Tischer, Alicia Prieto, Dolores Diaz, Ramon Kaneno
A fucomannogalactan from Rhizoctonia solani biomass was obtained after hot aqueous extraction and purified by freeze-thaw cycles and gel filtration chromatography on Sepharose CL-6B. The polysaccharide was homogeneous after HPSEC/RID analysis (Mw /Mn  ~ 1.1), displaying an average molecular weight of 15.4 × 103  Da. Its chemical structure was determined by methylation analysis (GC/MS) and spectroscopy (FTIR, 1D and 2D NMR). The polysaccharide had a branched α-1,6-linked Galp backbone with 66% linear residues, a number of which were at O-3 methylated...
April 9, 2018: International Journal of Biological Macromolecules
Dolors Mateo-Ortega, Xavier Gómez-Batiste, Jorge Maté, Elba Beas, Sara Ela, Cristina Lasmarias, Joaquín T Limonero
OBJECTIVE: To determine whether specific psychosocial interventions can ease discomfort in palliative care (PC) patients, particularly in those with high levels of pain or emotional distress. METHODS: Changes in the psychological parameters of 8333 patients were assessed in a quasi-experimental, prospective, multicenter, single group pretest/post-test study. Psychosocial care was delivered by 29 psychosocial care teams (PSTs; 137 professionals). Pre- and post-intervention changes in these variables were assessed: mood, anxiety, and emotional distress...
March 13, 2018: Journal of Palliative Medicine
Szymon Godlewski, Mads Engelund, Diego Peña, Rafał Zuzak, Hiroyo Kawai, Marek Kolmer, Jorge Caeiro, Enrique Guitián, K Peter C Vollhardt, Daniel Sánchez-Portal, Marek Szymonski, Dolores Pérez
Understanding the mechanisms involved in the covalent attachment of organic molecules to surfaces is a major challenge for nanotechnology and surface science. On the basis of classical organic chemistry mechanistic considerations, key issues such as selectivity and reactivity of the organic adsorbates could be rationalized and exploited for the design of molecular-scale circuits and devices. Here we use tris(benzocyclobutadieno)triphenylene, a singular Y-shaped hydrocarbon containing antiaromatic cyclobutadienoid rings, as a molecular probe to study the reaction of polycyclic conjugated molecules with atomic scale moieties, dangling-bond (DB) dimers on a hydrogen-passivated Ge(001):H surface...
April 12, 2018: Physical Chemistry Chemical Physics: PCCP
Antonio Ramos-Martínez, Alejandro Muñoz Serrano, Arístides de Alarcón González, Patricia Muñoz, Ana Fernández-Cruz, Maricela Valerio, María Carmen Fariñas, Manuel Gutiérrez-Cuadra, José Ma Miró, Josefa Ruiz-Morales, Dolores Sousa-Regueiro, José Miguel Montejo, Juan Gálvez-Acebal, Carmen HidalgoTenorio, Fernando Domínguez
PURPOSE: To analyze the influence of adding gentamicin to a regimen consisting of β-lactam or vancomycin plus rifampicin on survival in patients suffering from Staphylococcal prosthetic valve endocarditis (SPVE). METHODS: From January 2008 to September 2016, 334 patients with definite SPVE were attended in the participating hospitals. Ninety-four patients (28.1%) received treatment based on β-lactam or vancomycin plus rifampicin and were included in the study...
April 5, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Ana Lígia Silva de Lima, Luc J W Evers, Tim Hahn, Nienke M de Vries, Margaret Daeschler, Babak Boroojerdi, Dolors Terricabras, Max A Little, Bastiaan R Bloem, Marjan J Faber
BACKGROUND: People with PD (PWP) have an increased risk of becoming inactive. Wearable sensors can provide insights into daily physical activity and walking patterns. RESEARCH QUESTIONS: (1) Is the severity of motor fluctuations associated with sensor-derived average daily walking quantity? (2) Is the severity of motor fluctuations associated with the amount of change in sensor-derived walking quantity after levodopa intake? METHODS: 304 Dutch PWP from the Parkinson@Home study were included...
March 28, 2018: Gait & Posture
Dolors Bosch, Jesús Avilla, Selim Musleh, Marcela A Rodríguez
No abstract text is available yet for this article.
April 2018: Pesticide Biochemistry and Physiology
Frederick Annang, Ignacio Pérez-Victoria, Theresa Appiah, Guiomar Pérez-Moreno, Elisabeth Domingo-Contreras, Jesús Martín, Thomas Mackenzie, Luis Ruiz-Pérez, Dolores González-Pacanowska, Olga Genilloud, Francisca Vicente, Christian Agyare, Fernando Reyes
Bioassay-guided compound isolation led to the discovery of two new scalarane sesterterpenes (1 and 2) and two new triterpenes (3 and 4) from two mushroom species, Pleurotus ostreatus (edible) and Scleroderma areolatum, collected from Ghana. Their structures, including absolute stereochemistry, were established by spectroscopic methods, particularly (+)-ESI-TOF mass spectrometry and 1D and 2D NMR. The four compounds exhibited IC50 values of 1.65-7.63 μM against Plasmodium falciparum 3D7 and 5.04-13.65 μM against Trypanosoma cruzi Tulahuen C4 parasites and were also non-cytotoxic against HepG2 tumoral human liver cells...
April 3, 2018: Fitoterapia
Dolores Mino-León, María Eugenia Galván-Plata, Anda-Garay Anda-GarayJuan Carlos, Maura Estela Noyola-García, Davis Cooper
Background: Prescribing errors are a risk factor for patients to present adverse events and a strategy that has been incorporated into medical care to reduce them is the use of computer tools. The objective was to obtain the scientific basis for the development of prescribing error alerts for four chronic diseases with a higher prevalence in population ≥ 65 years. Methods: We reviewed the literature from 2010 to 2015 to obtain information about adverse events and adverse drug reactions associated with the use of drugs for the treatment of diabetes mellitus type 2 (DM2), hypertension, osteoarticular diseases (OD) and depression; the review included these databases: PubMed, OVID, Cochrane Library, LILACS, MEDES, Portal Mayores and SIETES...
2018: Revista Médica del Instituto Mexicano del Seguro Social
Francesco Paolo Busardo, Laura Almeida, Laura Cortes, Sally Sabraa, Marta Muniesaa, Oscar Garcia-Algara, Maria Dolores Gomez-Roiga
BACKGROUND: In the last two decades, the consumption of drugs of abuse among women of childbearing age has experienced a significant increase and results from analyses of surveys concerning maternal intake of psychoactive prescription drugs during pregnancy indicate that the rates of intake are increasing each year. Analyses of biological matrices such as maternal hair and neonatal meconium have recently been used for assessment of gestational consumption and consequent prenatal exposure to drugs of abuse in high-risk groups of women METHODS: Maternal hair and neonatal meconium were analyzed by validated chromatographic mass spectrometric methodologies to disclose gestational use of drugs of abuse and psychoactive prescription drugs and consequent prenatal exposure in a cohort of 513 mother-newborn dyads at the Sant Joan de Déu Barcelona Hospital, Spain, during 2012- 2013...
April 5, 2018: Current Pharmaceutical Biotechnology
Maria Infantino, Ora Shovman, Dolores Pérez, Mariangela Manfredi, Valentina Grossi, Maurizio Benucci, Francesca Li Gobbi, Francesca Bandinelli, Arianna Damiani, Paolo Moscato, Danielle Azoulay, Boris Gilburd, Yehuda Shoenfeld
Objective: The main objective was to determine the prevalence of anti-dense fine speckled (DFS70) antibodies in a stable population of undifferentiated connective tissue disease (UCTD) to better define their potential role. Methods: Immunological and clinical records of 91 long-standing UCTD patients were studied. DFS pattern was determined using the IIF ANA test on HEp-2 cells and anti-DFS70 antibodies were tested by chemiluminescence assay and by DFS70 line immunoassay...
April 3, 2018: Rheumatology
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