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JOURNAL ARTICLE
Dolores González de Llano, Mikel Roldán, Diego Taladrid, Edgard Relaño de la Guía, M Victoria Moreno-Arribas, Begoña Bartolomé
This work seeks to generate new knowledge about the mechanisms underlying the protective effects of cranberry against urinary tract infections (UTI). Using Caco-2 cells grown in Transwell inserts as an intestinal barrier model, we found that a cranberry-derived digestive fluid (containing 135 ± 5 mg of phenolic compounds/L) increased transepithelial electrical resistance with respect to control (ΔTEER = 54.5 Ω cm2 ) and decreased FITC-dextran paracellular transport by about 30%, which was related to the upregulation of the gene expression of tight junction (TJ) proteins (i...
April 23, 2024: Journal of Agricultural and Food Chemistry
#2
JOURNAL ARTICLE
Muhammad Imran Tousif, Zaheer Abbas, Mamona Nazir, Muhammad Saleem, Saba Tauseef, Areeba Hassan, Sajid Ali, Maqsood Ahmed, Jallat Khan, Gokhan Zengin, Abeer Hashem, Khalid F Almutairi, Graciela Dolores Avila-Quezada, Elsayed Fathi Abd-Allah
Tanacetum falconeri is a significant flowering plant that possesses cytotoxic, insecticidal, antibacterial, and phytotoxic properties. Its chemodiversity and bioactivities, however, have not been thoroughly investigated. In this work, several extracts from various parts of T. falconeri were assessed for their chemical profile, antioxidant activity, and potential for enzyme inhibition. The total phenolic contents of T. falconeri varied from 40.28 ± 0.47 mg GAE/g to 11.92 ± 0...
April 22, 2024: BMC complementary medicine and therapies
#3
Andras Heczey, David Steffin, Nisha Ghatwai, Antonino Montalbano, Purva Rathi, Amy Courtney, Azlann Arnett, Julien Fleurence, Ramy Sweidan, Tao Wang, Huimin Zhang, Prakash Masand, John Maris, Dan Martinez, Jennier Pogoriler, Navin Varadarajan, Sachin Thakkar, Deborah Lyon, Natasha Lapteva, Mei Zhuyong, Kalyani Patel, Dolores Lopez-Terrada, Carlos Ramos, Premal Lulla, Tannaz Armaghany, Bambi Grilley, Gianpietro Dotti, Leonid Metelitsa, Helen Heslop, Malcolm Brenner, Pavel Sumazin
Interleukin-15 (IL15) promotes the survival of T lymphocytes and enhances the antitumor properties of CAR T cells in preclinical models of solid neoplasms in which CAR T cells have limited efficacy1-4. Glypican-3 (GPC3) is expressed in a group of solid cancers5-10, and here we report the first evaluation in humans of the effects of IL15 co-expression on GPC3-CAR T cells. Cohort 1 patients (NCT02905188/NCT02932956) received GPC3-CAR T cells, which were safe but produced no objective antitumor responses and reached peak expansion at two weeks...
April 3, 2024: Research Square
#4
JOURNAL ARTICLE
Jichao Zhang, Baohua Sun, Isao Tanihata, Rituparna Kanungo, Christoph Scheidenberger, Satoru Terashima, Feng Wang, Frederic Ameil, Joel Atkinson, Yassid Ayyad, Soumya Bagchi, Dolores Cortina-Gil, Iris Dillmann, Alfredo Estradé, Alexey Evdokimov, Fabio Farinon, Hans Geissel, Giulia Guastalla, Rudolf Janik, Satbir Kaur, Ronja Knöbel, Jan Kurcewicz, Yury Litvinov, Michele Marta, Magdalena Mostazo, Ivan Mukha, Chiara Nociforo, Hooi Jin Ong, Stephane Pietri, Andrej Prochazka, Branislav Sitar, Peter Strmen, Maya Takechi, Junki Tanaka, Jossitt Vargas, Helmut Weick, John Stuart Winfield
We report the charge-changing cross sections (σcc ) of 24 p-shell nuclides on both hydrogen and carbon at about 900A MeV, of which 8,9 Li, 10-12 Be, 10,14,15 B, 14,15,17-22 N and 16 O on hydrogen and 8,9 Li on carbon are for the first time. Benefiting from the data set, we found a new and robust relationship between the scaling factor of the Glauber model calculations and the separation energies of the nuclei of interest on both targets. This allows us to deduce proton radii (Rp ) for the first time from the cross sections on hydrogen...
March 26, 2024: Science Bulletin
#5
Zoilo Morel, Tamara Martínez, Fernando Galeano, Judith Coronel, Lorena Quintero, Rolando Jimenez, Jorge Ayala, Sara Amarilla, Dolores Lovera, Celia Martínez de Cuellar
Paraguay is currently facing a new outbreak of Chikungunya virus. This report summarizes two severe cases of Chikungunya (CHIKV) infection, confirmed by real-time reverse transcription polymerase chain reaction. We present the cases of patients with acute CHIKV infection and multisystem involvement, with fever, rash, abdominal pain, vomiting, myocarditis, and coronary artery anomalies, very similar to the cases described in MIS-C related to SARS-CoV-2 during the COVID-19 Pandemic. Both patients received IVIG and methylprednisolone, with good clinical response...
April 2024: Reumatología clinica
#6
JOURNAL ARTICLE
Lucía Rodríguez-Pombo, María José de Castro-López, Paula Sánchez-Pintos, Jose Maria Giraldez-Montero, Patricija Januskaite, Goretti Duran-Piñeiro, M Dolores Bóveda, Carmen Alvarez-Lorenzo, Abdul W Basit, Alvaro Goyanes, Maria L Couce
Rare diseases are infrequent, but together they affect up to 6-10 % of the world's population, mainly children. Patients require precise doses and strict adherence to avoid metabolic or cardiac failure in some cases, which cannot be addressed in a reliable way using pharmaceutical compounding. 3D printing (3DP) is a disruptive technology that allows the real-time personalization of the dose and the modulation of the dosage form to adapt the medicine to the therapeutic needs of each patient. 3D printed chewable medicines containing amino acids (citrulline, isoleucine, valine, and isoleucine and valine combinations) were prepared in a hospital setting, and the efficacy and acceptability were evaluated in comparison to conventional compounded medicines in six children...
April 19, 2024: International Journal of Pharmaceutics
#7
JOURNAL ARTICLE
Ó A Escobar-Vidarte, V Alzate-Carvajal, J F Mier-García
BACKGROUND AND OBJECTIVE: Painful trigeminal neuropathy is a complex clinical entity due to its severity and refractoriness to pharmacological and interventional management. We describe our experience in treating refractory painful trigeminal neuropathy (RPTN) with gasserian ganglion stimulation (GGS). MATERIALS AND METHODS: Six patients with RPTN were treated with GGS in our Unit between 2019 and 2022. The following data were collected: socio-demographic characteristics, triggering event, duration of the disease and treatment received prior to surgery, pre- and post-intervention visual analogue scale (VAS) score, follow-up time, and pre- and post-intervention functionality and quality of life...
April 18, 2024: Revista española de anestesiología y reanimación
#8
JOURNAL ARTICLE
Laura Álvarez-Álvarez, María Rubín-García, Facundo Vitelli-Storelli, Silvia García, Cristina Bouzas, Miguel Ángel Martínez-González, Dolores Corella, Jordi Salas-Salvadó, Mireia Malcampo, J Alfredo Martínez, Ángel M Alonso-Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Miranda, Ramon Estruch, Francisco J Tinahones, José Lapetra, Lluís Serra-Majem, Aurora Bueno-Cavanillas, Camino García Fernández, Xavier Pintó, Miguel Delgado-Rodríguez, Pilar Matía-Martín, Josep Vidal, Clotilde Vázquez, Lidia Daimiel, Emilio Ros, Ana García-Arellano, María Ángeles Martínez, José V Sorlí, María Dolores Zomeño, Antonio García-Rios, Sandra González-Palacios, Margalida Monserrat-Mesquida, Itziar Abete, Antoni Colom Fernández, Rosa Casas, Naomi Cano Ibañez, Lucía Ugarriza, M Rosa Bernal-López, Maira Bes-Rastrollo, Indira Paz-Graniel, Eva M Asensio, Montse Fitó, Antonio P Arenas Larriva, Alejandro Oncina-Cánovas, Zenaida Vázquez, María Fernández de la Puente, Alejandra Pérez-Vega, Josep A Tur, Vicente Martín-Sánchez
OBJECTIVE: To estimate the environmental impact of a dietary intervention based on an energy-reduced Mediterranean diet (MedDiet) after one year of follow-up. METHODS: Baseline and 1-year follow-up data were used for 5800 participants aged 55-75 years with metabolic syndrome in the PREDIMED-Plus study. Food intake was estimated through a validated semiquantitative food consumption frequency questionnaire, and adherence to the MedDiet was estimated through the Diet Score...
April 18, 2024: Science of the Total Environment
#9
P Navarro Núñez, J Formigo Couceiro, S Otero Villaverde
Persistent knee pain in patients around the fifth decade of life is a frequent cause of attention in rehabilitation consultations. The most common cause of diagnosis is knee osteoarthritis, considering the existence of different degrees seen in simple radiographies. The advanced degrees present joint space reduction, osteophytosis and subchondral sclerosis; however, in the initial degrees, the findings are more subtle and sometimes nonexistent for conventional radiology. Clinical ultrasound has partly come to fill this «diagnostic gap», making it possible to detect meniscal extrusions and small osteophytes as signs of incipient osteoarthritis and to relate them as triggers of pain...
April 19, 2024: Rehabilitación
#10
JOURNAL ARTICLE
Celia Alvarez-Romero, Alejandro Polo-Molina, Eugenio Francisco Sánchez-Úbeda, Carlos Jimenez-De-Juan, Maria Pastora Cuadri-Benitez, Jose Antonio Rivas-Gonzalez, Jose Portela, Rafael Palacios, Carlos Rodriguez-Morcillo, Antonio Muñoz, Carlos Luis Parra-Calderon, Maria Dolores Nieto-Martin, Manuel Ollero-Baturone, Carlos Hernández-Quiles
BACKGROUND: Functional impairment is one of the most decisive prognostic factors in patients with complex chronic diseases. A more significant functional impairment indicates that the disease is progressing, which requires implementing diagnostic and therapeutic actions that stop the exacerbation of the disease. OBJECTIVE: This study aimed to predict alterations in the clinical condition of patients with complex chronic diseases by predicting the Barthel Index (BI), to assess their clinical and functional status using an artificial intelligence model and data collected through an internet of things mobility device...
April 19, 2024: JMIR Formative Research
#11
JOURNAL ARTICLE
Pedro Alvedro-Ruiz, Nerea Díaz-Ros, María García-García, Mar Merino-Romero, Iván Heredia-Alcalde, Belén Andresen-Lorca, Aranzazu Pérez-Plaza, María Dolores Pérez Del Caz
Because the head and neck are one of the most frequent locations of burns, it is of paramount importance that plastic surgeons and plastic surgical nurses understand the most effective surgical methods for treating neck contractures and the reconstructive technique required for each case. We introduce the case of a 42-year-old woman who presented with a severe postburn neck contracture that was reconstructed with a pedicled occipito-cervico-dorsal flap. We closed the donor-site wound primarily and completely covered the defect with good results...
April 2024: Plast Aesthet Nurs (Phila)
#12
JOURNAL ARTICLE
Isabel Carmona, Jose Rodriguez-Rodriguez, Dolores Alvarez, Carmen Noguera
This research aimed to investigate whether the mental space-time association of temporal concepts could be modulated by the availability of cognitive resources (in terms of working memory and inhibitory control capacities) and to explore whether access to this association could be an automatic process. To achieve this, two experiments were carried out. In Experiment 1, participants had to classify words with future and past meanings. The working memory load (high vs. low) was manipulated and the participants were grouped into quartiles according to their visuospatial working memory capacity (WMC)...
April 19, 2024: Psychonomic Bulletin & Review
#13
REVIEW
Otto Ruokolainen, Hanna Ollila, Tiina Laatikainen, Salla-Maaria Pätsi, Giulia Carreras, Giuseppe Gorini, Dolors Carnicer-Pont, Zsuzsa Cselkó, Romain Guignard, Maria Karekla, Biljana Kilibarda, Helena Koprivnikar, Angeliki Lambrou, Viêt Nguyen-Thanh, Efstathios Papachristou, Sotiria Schoretsaniti, Milena Vasic
Due to the continued detrimental effects of tobacco use, a growing number of countries are embracing the idea of tobacco endgame, meaning ending the tobacco epidemic instead of controlling it. This narrative review aims to synthesize and update the evidence from earlier scientific reviews on effective tobacco endgame measures, as well as to assess their integration to current national strategies among European countries with official tobacco endgame goals. The synthesis of the prior scientific literature found most evidence on product-focused and some evidence for supply-focused policies...
2024: Tobacco Prevention & Cessation
#14
JOURNAL ARTICLE
Sebastián Sanz-Martos, Cristina Álvarez-García, Carmen Álvarez-Nieto, Isabel M López-Medina, María Dolores López-Franco, Maria E Fernandez-Martinez, Lucía Ortega-Donaire
BACKGROUND: Previous research in nursing has found favorable results from the use of teaching methodologies alternative to lectures. One of the complementary methodologies used for university teaching is gamification, or the inclusion of game elements, creating a dynamic learning environment that allows the acquisition of knowledge and the development of other skills necessary for nursing students. The purpose of this study was to evaluate the effect of a gamification session on student satisfaction and knowledge scores in nursing students in simulated laboratory practice...
2024: PeerJ
#15
JOURNAL ARTICLE
Marina López-Arjona, José Joaquín Cerón, Sandra V Mateo, María Dolores Contreras-Aguilar, Silvia Martínez-Subiela
The objective of this research was to develop and validate two immunoassays for oxytocin measurement in human saliva, one using a monoclonal and the other a polyclonal antibody against oxytocin, whose affinity for oxytocin was tested by an antibody mapping epitope analysis. These assays were analytically validated and used to compare oxytocin concentrations with those obtained with a commercial kit before and after the extraction or reduction/alkylation (R/A) treatments to saliva samples. The assays were also used to evaluate changes in salivary oxytocin concentrations following a physical effort and an induced psychological stress, which have previously been described as situations that cause an increase in salivary oxytocin...
2024: PloS One
#16
JOURNAL ARTICLE
Víctor Serrano-Gimeno, Alba Diestre, Marina Agustin-Alcain, Maria J Portella, Javier de Diego-Adeliño, Thaïs Tiana, Nora Cheddi, Alejandro Distefano, Guillermo Dominguez, Marina Arias, Victor Cardoner, Dolors Puigdemont, Victor Perez, Narcís Cardoner
BACKGROUND: The COVID-19 pandemic has been extensively discussed in the context of its effect on mental health. Although global suicide rates have remained stable during the pandemic, the specific effect on non-fatal suicide behaviours during and after the pandemic remains underexplored. This study aims to investigate patterns of non-fatal suicide behaviours before, during, and after the pandemic. METHODS: In this cohort study, we used data from all hospitals in Catalonia, Spain, collected through the Catalan Suicide Risk Code, which is a specifically designed suicide attempt surveillance protocol, involving a face-to-face, in-depth psychiatric evaluation, after a Catalan resident presents any suicide risk behaviour in any public health-care setting...
May 2024: Lancet Psychiatry
#17
JOURNAL ARTICLE
Melina Peressini, Rosario Garcia-Campelo, Bartomeu Massuti, Cristina Marti, Manuel Cobo, Vanesa Gutiérrez, Manuel Dómine, Jose Fuentes, Margarita Majem, Javier de Castro, Juan Felipe Cordoba, Maria Pilar Diz, Dolores Isla, Emilio Esteban, Enric Carcereny, Laia Vila, Alberto Moreno-Vega, Silverio Ros, Amaia Moreno, Francisco Javier Garcia, Gerardo Huidobro, Carlos Aguado, Victor Cebey-Lopez, Javier Valdivia, Ramon Palmero, Pilar Lianes, Marta Lopez-Brea, Oscar Juan Vidal, Mariano Provencio, Edurne Arriola, Javier Baena, Mercedes Herrera, Helena Bote, Magdalena Molero, Vera Adradas, Santiago Ponce-Aix, Angel Nuñez-Buiza, Álvaro Ucero, Susana Hernandez, Fernando Lopez-Rios, Esther Conde, Luis Paz-Ares, Jon Zugazagoitia
BACKGROUND: Transcriptomic subtyping holds promise for personalized therapy in extensive-stage small-cell lung cancer (ES-SCLC). In this study, we aimed to assess intratumoral transcriptomic subtype diversity and to identify biomarkers of long-term chemoimmunotherapy benefit in human ES-SCLC. PATIENTS AND METHODS: We analyzed tumor samples from 58 ES-SCLC patients enrolled in two multicenter single-arm phase IIIb studies evaluating front-line chemoimmunotherapy in Spain: n=32 from the IMfirst trial, and n=26 from the CANTABRICO trial...
April 17, 2024: Clinical Cancer Research
#18
Magdalena Stepien, Talita Duarte-Salles, Veronika Fedirko, Antonia Trichopoulou, Pagona Lagiou, Christina Bamia, Kim Overvad, Anne Tjønneland, Louise Hansen, Marie-Christine Boutron-Ruault, Guy Fagherazzi, Gianluca Severi, Tilman Kühn, Rudolf Kaaks, Krasimira Aleksandrova, Heiner Boeing, Eleni Klinaki, Domenico Palli, Sara Grioni, Salvatore Panico, Rosario Tumino, Alessio Naccarati, H Bas Bueno-de-Mesquita, Petra H Peeters, Guri Skeie, Elisabete Weiderpass, Christine L Parr, José Ramón Quirós, Genevieve Buckland, Esther Molina-Montes, Pilar Amiano, Maria-Dolores Chirlaque, Eva Ardanaz, Emily Sonestedt, Ulrika Ericson, Maria Wennberg, Lena Maria Nilsson, Kay-Tee Khaw, Nick Wareham, Kathryn E Bradbury, Heather A Ward, Isabelle Romieu, Mazda Jenab
No abstract text is available yet for this article.
April 17, 2024: European Journal of Nutrition
#19
REVIEW
Esther Hernández Rovira, Tamara Rial Rebullido, Dolors Cañabate, Carlota Torrents Martí
Introduction: Hypopressive exercise (HE) can be viewed as a mind-body activity, characterized by the integration of breath control and stretching postures. Proponents of HE claim that this type of training can offer potential therapeutic or health benefits. To date, there is no existing comprehensive published overview on HE. This scoping review aims to map and summarize the current literature reporting data on HE and identify key knowledge gaps and future research directions. Methods: This review considered studies that report on the immediate, short-, or long-term practice of HE regardless of condition, sex, age, and/or level of practice or physical condition...
April 17, 2024: J Integr Complement Med
#20
JOURNAL ARTICLE
Annibale Biggeri, Giorgia Stoppa, Laura Facciolo, Giuliano Fin, Silvia Mancini, Valerio Manno, Giada Minelli, Federica Zamagni, Michela Zamboni, Dolores Catelan, Lauro Bucchi
BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) are associated with many adverse health conditions. Among the main effects is carcinogenicity in humans, which deserves to be further clarified. An evident association has been reported for kidney cancer and testicular cancer. In 2013, a large episode of surface, ground and drinking water contamination with PFAS was uncovered in three provinces of the Veneto Region (northern Italy) involving 30 municipalities and a population of about 150,000...
April 16, 2024: Environmental Health
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