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Luminita N Cima, Sorina C Martin, Ioana M Lambrescu, Lavinia Stejereanu, Cristina Zaharia, Anca Colita, Simona Fica
BACKGROUND: Thyroid dysfunction (TD) was usually described in hematopoietic stem cell transplantation (HSCT) recipients who were given total body irradiation (TBI) in the conditioning regimen. Because previous studies have reported discrepant results regarding the presence of long-term thyroid complications in HSCT survivors following chemotherapy-only conditioning, we investigated the frequency of thyroid abnormalities in a series of children treated with HSCT for different disorders without TBI as part of the conditioning protocol...
June 23, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
Hiroshige Mikamo, Kazuhiro Tateda, Katsunori Yanagihara, Shinya Kusachi, Yoshio Takesue, Takashi Miki, Yuki Oizumi, Kazuaki Gamo, Atsuki Hashimoto, Junko Toyoshima, Kenichi Kato
We assessed the efficacy and safety of fidaxomicin, a narrow-spectrum macrocyclic antibiotic, for treating inpatients with Clostridioides (Clostridium) difficile infection (CDI) in Japan. The objective was to demonstrate the non-inferior efficacy of fidaxomicin versus vancomycin. This Phase III, vancomycin-controlled, double-blind, parallel-group study enrolled adults with CDI. Patients were randomly assigned to receive fidaxomicin (200 mg twice daily, orally) or vancomycin (125 mg four-times daily, orally) for 10 days...
June 19, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
A Jabrocka-Hybel, A Skalniak, J Piątkowski, R Turek-Jabrocka, P Vyhouskaya, A Ludwig-Słomczyńska, J Machlowska, P Kapusta, M Małecki, D Pach, M Trofimiuk-Müldner, K Lizis-Kolus, A Hubalewska-Dydejczyk
PURPOSE: Our insight in the genetics of Hashimoto's thyroiditis (HT) has become clearer through information provided by genome-wide association studies and candidate gene studies, but remains still not fully understood. Our aim was to assess how many different genetic risk variants contribute to the development of HT. METHODS: 147 HT cases (10.2% men) and 147 controls (13.6% men) were qualified for the analysis. Intrinsic and environmental factors were controlled for...
June 21, 2018: Journal of Endocrinological Investigation
Hiroyuki Takagi, Tatsuya Ikehara, Yuto Kashiwagi, Kumi Hashimoto, Isamu Nanchi, Atsuyuki Shimazaki, Hirohide Nambu, Hideo Yukioka
Intramyocellular lipid (IMCL) accumulation in skeletal muscle greatly contributes to lipid-induced insulin resistance. Since acetyl-CoA carboxylase 2 (ACC2) negatively modulates mitochondrial fatty acid oxidation (FAO) in skeletal muscle, ACC2 inhibition is expected to reduce IMCL via elevation of FAO and to attenuate insulin resistance. However, the concept of substrate competition suggests that enhanced FAO results in reduced glucose utilization because of an excessive acetyl-CoA pool in mitochondria. To identify how ACC2-regulated FAO affects IMCL accumulation and glucose metabolism, we generated ACC2 knockout (ACC2-/-) mice and investigated skeletal muscle metabolites associated with fatty acid and glucose metabolism, as well as whole-body glucose metabolism...
June 20, 2018: Endocrinology
Haruki Shida, Nobuhiro Hashimoto, Yoshihiro Kusunoki, Fumihiko Hattanda, Yayoi Ogawa, Terumasa Hayashi, Daigo Nakazawa, Sakiko Masuda, Utano Tomaru, Akihiro Ishizu
BACKGROUND: Neutrophil extracellular traps (NETs) are web-like DNA decorated with antimicrobial proteins, such as myeloperoxidase (MPO), which are extruded from activated neutrophils. Although NETs are essential in innate immunity, an excessive formation of NETs has adverse effects, e.g., induction of anti-neutrophil cytoplasmic antibody (ANCA), to the hosts. Since ANCA can induce NET formation in the primed neutrophils, a positive feedback loop can be formed between NETs and ANCA, which is called "ANCA-NETs vicious cycle...
June 22, 2018: BMC Nephrology
Fumihisa Nakamura, Ichiro Tsukamoto, Shinji Inoue, Kazuhiko Hashimoto, Masao Akagi
Angiotensin II type 1 receptor (AT1R) appears to have a mechanosensing function in a number of cell types. The purpose of this study was to examine whether AT1R expressed in articular chondrocytes is involved in osteoarthritis (OA) progression in vivo and whether cyclic compressive loading activates the AT1R and stimulates hypertrophic differentiation of chondrocytes in vitro . The relationships between the modified Mankin score for cartilage degeneration and the expression of AT1R and type X collagen (Col X) were studied in mouse knees with OA induced using the destabilization-of-medial-meniscus model...
June 2018: FEBS Open Bio
Kana Takeda, Taku Fujimura, Chunbing Lyu, Akira Tsukada, Kenichiro Tsuchiyama, Akira Hashimoto, Setsuya Aiba
Radiation-associated angiosarcoma (RAAS) is a type of radiation-associated sarcoma (RAS) that develops at the previous field of radiation in breast cancer patients. Although several reports have suggested a poor prognosis for RAAS, the 5-year overall survival of RAAS is better than that of cutaneous angiosarcoma (CAS), suggesting that the prognostic factors of RAAS and CAS might be different, at least in part. In this report, we describe a case of RAAS, and employed immunohistochemical (IHC) staining of PD-L1 and MMP9 as well as periostin, IL-4, and CD163...
May 2018: Case Reports in Oncology
Daijiro Ueda, Saori Matsugane, Wataru Okamoto, Masayuki Hashimoto, Tsutomu Sato
Non-C5-units terpenoids (norisoprenoids) having an acetonyl group are widely distributed in nature, especially in crustacean hormones, insect pheromones, plant odorants, and microbial volatiles. However, studies on the biosynthesis of norisoprenoids are scarce. In this study, we identified the C33 norisoprenoid, (all-E)-farnesylfarnesylacetone, from Bacillus spp. and elucidated for the first time, to our knowledge, that superoxide mediates the cleavage of menaquinones (vitamin K) to form norisoprenoids in saponification treatment...
June 21, 2018: Angewandte Chemie
Kazuhiro Kitajima, Shingo Yamamoto, Soichi Odawara, Kaoru Kobayashi, Masayuki Fujiwara, Norihiko Kamikonya, Kazuhito Fukushima, Yukako Nakanishi, Takahiko Hashimoto, Yusuke Yamada, Toru Suzuki, Akihiro Kanematsu, Michio Nojima, Koichiro Yamakado
We compared 11C-choline and FDG PET/CT scan findings for the staging and restaging of prostate cancer. Twenty Japanese prostate cancer patients underwent 11C-choline and FDG PET/CT before (n=5) or after (n=15) treatment. Using a five-point scale, we compared these scanning modalities regarding patient- and lesion-based diagnostic performance for local recurrence, untreated primary tumor, and lymph node and bony metastases. Of the 20 patients, documented local lesions, and node and bony metastases were present in 11 (55...
June 2018: Acta Medica Okayama
Taiki Kambara, Ryuta Tanimoto, Motoo Araki, Takashi Saika, Hideaki Hashimoto, Tadashi Oeda, Tomoyasu Tsushima, Shunji Hayata, Yasutomo Nasu, Yasuyuki Kobayashi
We retrospectively analyzed the factors related to postoperative cardiovascular (CV) events in patients undergoing partial nephrectomy (PN) or radical nephrectomy (RN) for clinical T1 renal cell carcinoma (RCC). We identified 570 patients who underwent PN or RN for T1 renal cell carcinoma between January 1998 and December 2009 at our institution and related hospitals. We determined the cumulative incidence rate of CV events and overall survival (OS) using Kaplan-Meier survival curves with a log-rank test, and we evaluated the risk for an increase in CV events and OS using Cox proportional hazard regression...
June 2018: Acta Medica Okayama
Taiki Chono, Masahisa Onoguchi, Akiyoshi Hashimoto
BACKGROUND: Assessment of left ventricular (LV) diastolic function is important because it is possible to detect early sign of myocardial ischemia by this assessment. The purpose of this study was to compare between electrocardiogram (ECG) -gated myocardial perfusion single photon emission computed tomography (G-SPECT) and ultrasound echocardiography in assessment of LV diastolic function in the small heart (SH). METHODS: The study population consisted of 144 patients who underwent both G-SPECT and ultrasound echocardiography...
2018: Nihon Hoshasen Gijutsu Gakkai Zasshi
Eiichiro Okumura, Noriyuki Hashimoto
In Japan, medical liquid-crystal display (LCD) and general LCD monitors have color temperatures of 7500 and 6500 K, respectively. The differences in color temperature make it difficult for radiologists to judge whether the same color is being displayed on the monitor. Therefore, the radiologist may overlook lesions. We examined chromaticity on a color scale test pattern to determine the relationships between color temperature (6500-12,500 K) of the medical color LCD monitors, there are three types of fluorescent light and three types of illuminance LCD monitors...
2018: Nihon Hoshasen Gijutsu Gakkai Zasshi
Masahiko Takahashi, Maiko Hashimoto, Masumi Uehara
The present study aimed to prepare a small acute-phase cerebral infarction phantom made of gelatin and sucrose to simulate brain parenchymal cells, and a phantom made of collagen peptides and sucrose to simulate cerebral infarction for diffusion-weighted imaging (DWI). During the preparation of gelatin and sucrose mixture (17.0 wt% gelatin, 20.0 wt% sucrose), a cylindrical wooden bar was placed in the center of the phantom and covered with a heat-shrinkable film to ensure space remained after gelling. A mixed solution composed of collagen peptide and sucrose (16...
2018: Nihon Hoshasen Gijutsu Gakkai Zasshi
Takamasa Kayama, Shinya Sato, Kaori Sakurada, Junki Mizusawa, Ryo Nishikawa, Yoshitaka Narita, Minako Sumi, Yasuji Miyakita, Toshihiro Kumabe, Yukihiko Sonoda, Yoshiki Arakawa, Susumu Miyamoto, Takaaki Beppu, Kazuhiko Sugiyama, Hirohiko Nakamura, Motoo Nagane, Yoko Nakasu, Naoya Hashimoto, Mizuhiko Terasaki, Akira Matsumura, Eiichi Ishikawa, Toshihiko Wakabayashi, Yasuo Iwadate, Shiro Ohue, Hiroyuki Kobayashi, Manabu Kinoshita, Kenichiro Asano, Akitake Mukasa, Katsuyuki Tanaka, Akio Asai, Hideo Nakamura, Tatsuya Abe, Yoshihiro Muragaki, Koichi Iwasaki, Tomokazu Aoki, Takao Watanabe, Hikaru Sasaki, Shuichi Izumoto, Masahiro Mizoguchi, Takayuki Matsuo, Hideo Takeshima, Motohiro Hayashi, Hidefumi Jokura, Takashi Mizowaki, Eiji Shimizu, Hiroki Shirato, Masao Tago, Hiroshi Katayama, Haruhiko Fukuda, Soichiro Shibui
Purpose Whereas whole-brain radiotherapy (WBRT) has been the standard treatment of brain metastases (BMs), stereotactic radiosurgery (SRS) is increasingly preferred to avoid cognitive dysfunction; however, it has not been clearly determined whether treatment with SRS is as effective as that with WBRT or WBRT plus SRS. We thus assessed the noninferiority of salvage SRS to WBRT in patients with BMs. Patients and Methods Patients age 20 to 79 years old with performance status scores of 0 to 2-and 3 if caused only by neurologic deficits-and with four or fewer surgically resected BMs with only one lesion > 3 cm in diameter were eligible...
June 20, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Tatjana Zake, Sandra Skuja, Ieva Kalere, Ilze Konrade, Valerija Groma
Th17 cells together with their hallmark cytokine interleukin (IL)-17 were identified as crucial contributing factors in the pathogenesis of thyroid autoimmunity. The cytokine-regulated tight junction (Tj) disruption is thought to be essential in the initiation and/or development of several diseases. Still, the role of IL-17 maintaining Tj integrity in autoimmune thyroid diseases (AITDs) has not yet been evaluated. We aimed to investigate integrity of the thyroid follicle by studying immunoexpression of cellular Tj - zonula occludens (ZO)-1 and claudin-1 proteins coupled to IL-17A and CD68 detection in AITD patients compared with controls...
June 2018: Medicine (Baltimore)
Yota Sato, Taku Fujimura, Yumi Kambayashi, Kayo Tanita, Hisayuki Tono, Akira Hashimoto, Setsuya Aiba
Although therapies for advanced melanoma have been greatly improved by the development of immune checkpoint inhibitors and BRAF/mitogen-activated protein kinase kinase inhibitors, there are still many concerns about the administration of these novel drugs. Therefore, to combine these therapies sequentially at appropriate time points of the disease is important. In this report, we report two cases in which dabrafenib and trametinib therapy for advanced melanoma failed but were successfully controlled by nivolumab monotherapy, and investigated the sera sCD163, CCL22 and CXCL10 as biomarkers for tumor progression...
June 20, 2018: Journal of Dermatology
Kenichi Goda, Junko Fujisaki, Ryu Ishihara, Manabu Takeuchi, Akiko Takahashi, Yasuhiro Takaki, Dai Hirasawa, Kumiko Momma, Yuji Amano, Kazuyoshi Yagi, Hiroto Furuhashi, Tomoki Shimizu, Takashi Kanesaka, Satoru Hashimoto, Yoichiro Ono, Taku Yamagata, Junko Fujiwara, Takane Azumi, Masako Nishikawa, Gen Watanabe, Yasuo Ohkura, Tsuneo Oyama
AIM AND METHODS: The Japan Esophageal Society created a working committee group consisting of 11 expert endoscopists and 2 pathologists with expertise in Barrett's esophagus (BE) and esophageal adenocarcinoma. The group developed a consensus-based classification for the diagnosis of superficial BE-related neoplasms using magnifying endoscopy. RESULTS: The classification has three characteristics: simplified, an easily understood classification by incorporating the diagnostic criteria for the early gastric cancer, including the white zone and demarcation line, and the presence of a modified flat pattern corresponding to non-dysplastic histology by adding novel diagnostic criteria...
June 19, 2018: Esophagus: Official Journal of the Japan Esophageal Society
Hourin Cho, Taiki Hashimoto, Hiroshi Yoshida, Hirokazu Taniguchi, Reiko Ogawa, Taisuke Mori, Nobuyoshi Hiraoka, Yutaka Saito, Shigeki Sekine
AIMS: Sessile serrated adenoma/polyp (SSA/P) is regarded as a genetically homogeneous entity, with most lesions harboring the BRAF V600E mutation. The present study aimed to reappraise the genetic heterogeneity of SSA/Ps and its clinicopathological significance. METHODS AND RESULTS: We performed next-generation sequencing of 272 SSA/Ps without dysplasia and evaluated morphologic and molecular features associated with the respective genotypes. BRAF V600E, BRAF non-V600E, KRAS, and NRAS mutations were found in 223 (82...
June 19, 2018: Histopathology
Yujiro Tanaka, Takao Hashimoto, Daisuke Watanabe, Hirofumi Okada, Daichi Kato, Shigeru Aoyagi, Jiro Akimoto, Michihiro Kohno
PURPOSE: Pre-operative embolization is an effective treatment strategy for hypervascular intracranial and skull base tumors. However, neurological complications resulting from tumor swelling, cranial nerve ischemia, or hemorrhage can occur after embolization. The purpose of this study was to examine the relationship between neurological complications following pre-operative embolization and minor adverse events including fever, headache, or increasing inflammation, which are common after embolization for abdominal tumors (i...
June 18, 2018: Neuroradiology
Harutoyo Hirano, Renjo Takama, Ryo Matsumoto, Hiroshi Tanaka, Hiroki Hirano, Zu Soh, Teiji Ukawa, Tsuneo Takayanagi, Haruka Morimoto, Ryuji Nakamura, Noboru Saeki, Haruki Hashimoto, Shogo Matsui, Shinji Kishimoto, Nozomu Oda, Masato Kajikawa, Tatsuya Maruhashi, Masashi Kawamoto, Masao Yoshizumi, Yukihito Higashi, Toshio Tsuji
This paper proposes a novel non-invasive method for assessing the vascular endothelial function of lower-limb arteries based on the dilation rate of air-cuff plethysmograms measured using the oscillometric approach. The principle of evaluating vascular endothelial function involves flow-mediated dilation. In the study conducted, blood flow in the dorsal pedis artery was first monitored while lower-limb cuff pressure was applied using the proposed system. The results showed blood flow was interrupted when the level of pressure was at least 50 mmHg higher than the subject's lower-limb systolic arterial pressure and that blood flow velocity increased after cuff release...
June 18, 2018: Scientific Reports
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