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https://www.readbyqxmd.com/read/28731134/a-novel-gene-expression-scoring-system-for-accurate-diagnosis-of-basaloid-squamous-cell-carcinoma-of-the-esophagus
#1
Takeshi Tada, Reiko Honma, Jun-Ichi Imai, Zenichiro Saze, Michihiko Kogure, Shigeru Marubashi, Kazuhiro Tasaki, Masamitu Unakami, Junji Ezaki, Hirosumi Tamura, Akira Nishikawa, Yuko Hashimoto, Satoshi Waguri, Shinya Watanabe, Mitsukazu Gotoh
Basaloid squamous cell carcinoma of the esophagus (BSCE) is a rare variant of squamous cell carcinoma that is difficult to distinguish from other carcinomas by preoperative endoscopic biopsy because of its histological varieties. Accurate diagnosis is essential for adequate treatment, and the methods proposed so far (e.g., immunohistochemical staining) have limitations. In this study, we tried to identify the characteristic bundles of gene expression in BSCE using comprehensive gene expression analysis (CGEA)...
July 19, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28728146/chronic-kidney-disease-predicts-survival-in-patients-with-idiopathic-pulmonary-fibrosis
#2
Kohei Ikezoe, Tomohiro Handa, Kiminobu Tanizawa, Hideki Yokoi, Takeshi Kubo, Kensaku Aihara, Akihiko Sokai, Yoshinari Nakatsuka, Seishu Hashimoto, Kiyoshi Uemasu, Susumu Sato, Shigeo Muro, Sonoko Nagai, Motoko Yanagita, Kazuo Chin, Toyohiro Hirai, Yoshio Taguchi, Michiaki Mishima
BACKGROUND: The prevalence of chronic kidney disease (CKD) increases with age as with idiopathic pulmonary fibrosis (IPF). OBJECTIVES: We assessed the prevalence of CKD (stages 3-5) and investigated the relationship of CKD to clinical features and outcomes in patients with IPF. METHODS: This study comprised 123 patients with IPF; 61 subjects with chronic obstructive pulmonary disease (COPD), which was reportedly associated with CKD, were also enrolled as a disease control...
July 21, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28727885/sustained-activation-of-the-unfolded-protein-response-induces-cell-death-in-fuchs-endothelial-corneal-dystrophy
#3
Naoki Okumura, Miu Kitahara, Hirokazu Okuda, Keisuke Hashimoto, Emi Ueda, Makiko Nakahara, Shigeru Kinoshita, Robert D Young, Andrew J Quantock, Theofilos Tourtas, Ursula Schlötzer-Schrehardt, Friedrich Kruse, Noriko Koizumi
Purpose: The unfolded protein response (UPR) is believed to play a role in the pathogenesis of Fuchs' endothelial corneal dystrophy (FECD). The purpose of this study was to investigate whether unfolded proteins accumulate in the corneal endothelium in FECD and if they are involved in triggering cell death. Methods: Descemet's membranes with corneal endothelial cells (CECs) were obtained during keratoplasty, and expression of aggresomes, type 1 collagen, fibronectin, and agrin was evaluated...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28727735/we-perceive-a-mind-in-a-robot-when-we-help-it
#4
Tetsushi Tanibe, Takaaki Hashimoto, Kaori Karasawa
People sometimes perceive a mind in inorganic entities like robots. Psychological research has shown that mind perception correlates with moral judgments and that immoral behaviors (i.e., intentional harm) facilitate mind perception toward otherwise mindless victims. We conducted a vignette experiment (N = 129; Mage = 21.8 ± 6.0 years) concerning human-robot interactions and extended previous research's results in two ways. First, mind perception toward the robot was facilitated when it received a benevolent behavior, although only when participants took the perspective of an actor...
2017: PloS One
https://www.readbyqxmd.com/read/28726894/photocatalytic-hydrogenation-of-furan-to-tetrahydrofuran-in-alcoholic-suspensions-of-metal-loaded-titanium-iv-oxide-without-addition-of-hydrogen-gas
#5
Kousuke Nakanishi, Atsuhiro Tanaka, Keiji Hashimoto, Hiroshi Kominami
The use of metal co-catalysts broadens the application of photocatalytic reduction without the use of dihydrogen (H2) gas. We examined photocatalytic hydrogenation of furan, a representative heterocyclic compound and a compound derived from biomass, in alcoholic suspensions of metal-loaded titanium(iv) oxide (TiO2) under a H2-free condition and we found that furan was almost quantitatively hydrogenated to tetrahydrofuran with a high apparent quantum efficiency of 37% at 360 nm when palladium was used as a co-catalyst...
July 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28726872/specific-fluorescence-labeling-of-target-proteins-by-using-a-ligand-4-azidophthalimide-conjugate
#6
Kosuke Chiba, Miwako Asanuma, Minoru Ishikawa, Yuichi Hashimoto, Kosuke Dodo, Mikiko Sodeoka, Takao Yamaguchi
We herein propose a simple affinity-labeling method using a ligand-4-azidophthalimide (AzPI) conjugate. As a proof of concept, we show that two different ligand-AzPI conjugates enabled highly specific fluorescence labeling of their individual target proteins even in crude cell lysates. This method was also applied to label endogenous target proteins inside living cells.
July 20, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28725903/suppressive-effects-of-dietary-epa-rich-fish-oil-on-the-degradation-of-elastin-fibers-in-the-aortic-wall-in-nicotine-administered-mice
#7
Hirona Kugo, Nobuhiro Zaima, Megumi Onozato, Chie Miyamoto, Keisuke Hashimoto, Kenichi Yanagimoto, Tatsuya Moriyama
Abdominal aortic aneurysm (AAA) is a vascular disease involving gradual dilation of the abdominal aorta. Recent studies suggest that nicotine, which is a primary component in cigarette smoke, is closely associated with the development and rupture of an AAA. Nicotine accelerates AAA development through the weakening of the vascular wall by increasing oxidative stress and matrix metalloproteinase (MMP)-2 expression. However, little is known about preventing the AAA induced by nicotine. A non-surgical means of preventing the weakening of the vascular wall before the onset of AAA by functional food factors would be a valuable option over surgery...
July 20, 2017: Food & Function
https://www.readbyqxmd.com/read/28725057/efficient-generation-of-single-domain-antibodies-with-high-affinities-and-enhanced-thermal-stabilities
#8
Naoya Shinozaki, Ryuji Hashimoto, Kiichi Fukui, Susumu Uchiyama
Single domain antibodies (sdAbs), made of natural single variable regions of camelid or cartilaginous fish antibodies, or unpaired variable regions of mouse or human IgGs, are some of the more promising biologic modalities. However, such conventional sdAbs have difficulties of either using unwieldy animals for immunization or having high affinity deficiencies. Herein, we offer a versatile method to generate rabbit variable domain of heavy chain (rVH) derived sdAbs with high affinities (K D values of single digit nM or less) and enhanced thermal stabilities (equal to or even higher than those of camelid derived sdAbs)...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28724913/time-averaged-disease-activity-fits-better-joint-destruction-in-rheumatoid-arthritis
#9
Hideaki Tsuji, Koichiro Yano, Moritoshi Furu, Noriyuki Yamakawa, Katsunori Ikari, Motomu Hashimoto, Hiromu Ito, Takao Fujii, Wataru Yamamoto, Koichiro Ohmura, Atsuo Taniguchi, Shigeki Momohara, Fumihiko Matsuda, Cornelia F Allaart, Hisashi Yamanaka, Tsuneyo Mimori, Chikashi Terao
Disease activity of rheumatoid arthritis (RA), evaluated as Disease Activity Score (DAS), is associated with joint destruction. Since joint destruction reflects the history of disease activities, we hypothesized that time-averaged disease activity would better correlate with joint destruction than one-time disease activity. We recruited RA patients in IORRA (n = 557) and KURAMA (n = 204) cohorts, and calculated time-averaged DAS28 to model a modified Sharp/van der Heijde score (SHS). We evaluated the fitting of the model using time-averaged DAS28 among 1000 models in which we randomly picked up one-time DAS28...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28724872/learning-advanced-medical-technology-and-think-about-the-future-etc
#10
Hiroshi Sakai, Naoki Hashimoto, Ayano Shoji, Saki Kimoto, Reina Tsuruoka, Akiko Ooki, Chiharu Kai, Yuki Hiramatsu
No abstract text is available yet for this article.
2017: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/28724865/proposal-of-a-new-index-based-on-signal-to-noise-ratio-for-low-contrast-detectability-in-computed-tomographic-imaging
#11
Junichi Hashimoto, Shinji Abe, Yoshiyuki Ishimori, Masahiko Monma, Akio Tsumuraya, Kaneyoshi Miyauchi
The low-contrast detectability of computed tomography (CT) images is commonly evaluated by the contrast-to-noise ratio (CNR) because of its convenience to measure. However, the correlation between CNR and visual detectability is poor because the CNR is a simple index determined by both the contrast of the object and the standard deviation of the image noise. On the other hand, the signal-to-noise ratio (SNR), especially SNR based on the statistical decision theory model (SNRS, D) and SNR based on the matched-filter model (SNRM) are considered superior to CNR...
2017: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/28724639/production-of-reactive-persulfide-species-in-chronic-obstructive-pulmonary-disease
#12
Tadahisa Numakura, Hisatoshi Sugiura, Takaaki Akaike, Tomoaki Ida, Shigemoto Fujii, Akira Koarai, Mitsuhiro Yamada, Katsuhiro Onodera, Yuichiro Hashimoto, Rie Tanaka, Kei Sato, Yutaka Shishikura, Taizou Hirano, Satoru Yanagisawa, Naoya Fujino, Tatsuma Okazaki, Tsutomu Tamada, Yasushi Hoshikawa, Yoshinori Okada, Masakazu Ichinose
BACKGROUND: Oxidative stress is a major aetiological factor driving chronic obstructive pulmonary disease (COPD). Recently recognised as potent antioxidants, reactive persulfide and polysulfide species are biosynthesised by cystathionine β-synthase and cystathionine γ-lyase. The production of reactive persulfide and polysulfide species in the lungs of patients with COPD remain unknown. OBJECTIVES: The aim of this study was to examine the production of reactive persulfides and polysulfides, such as glutathione persulfide (GSSH), cysteine persulfide (CysSSH) and glutathione trisulfide (GSSSH), in lung-resident cells and epithelial lining fluid (ELF) obtained from patients with mild to moderate COPD...
July 19, 2017: Thorax
https://www.readbyqxmd.com/read/28724185/myo-inositol-plus-selenium-supplementation-restores-euthyroid-state-in-hashimoto-s-patients-with-subclinical-hypothyroidism
#13
M Nordio, S Basciani
OBJECTIVE: Clinical evidence suggests that oral supplementation with myo-inositol (MI) and selenium (Se) is useful in the treatment of autoimmune thyroiditis. The purpose of this study was to highlight the positive response of Hashimoto's patients with subclinical hypothyroidism (SH) treated with MI and Se (MI-Se) in restoring a normal thyroid function. PATIENTS AND METHODS: A total of 168 patients with Hashimoto's thyroiditis (HT) having Thyroid Stimulating Hormone (TSH) levels between 3 and 6 µIU/ml were randomized into 2 groups: one receiving MI-Se and the other one Se alone...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28724172/favorable-effects-of-myo-inositol-selenomethionine-or-their-combination-on-the-hydrogen-peroxide-induced-oxidative-stress-of-peripheral-mononuclear-cells-from-patients-with-hashimoto-s-thyroiditis-preliminary-in-vitro-studies
#14
S Benvenga, T Vicchio, F Di Bari, R Vita, P Fallahi, S M Ferrari, S Catania, C Costa, A Antonelli
OBJECTIVE: The aim of this study was to assess whether blood mononuclear cells (PBMC) from Hashimoto's thyroiditis (HT) and control women, were protected from in vitro H2O2-induced oxidative stress after addition of antioxidants. PATIENTS AND METHODS: PBMC, from 8 HT women and 3 healthy women (controls), were cultured in the presence of 200 µM H2O2 alone, with subsequent addition of myo-inositol (Myo) (0.25, 0.5, 1.0 µM), selenomethionine (SelMet) (0.25, 0.5, 1...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28724056/prevalence-of-pancreatic-autoantibodies-in-non-diabetic-patients-with-autoimmune-thyroid-disease-and-its-relation-to-insulin-secretion-and-glucose-tolerance
#15
Carolina Sallorenzo, Regina Silva, Teresa Kasamatsu, Sérgio Dib
Objective: We evaluated the prevalence of glutamic acid decarboxylase (GADA) and tyrosine phosphatase-protein antibodies (IA2A), their titers and their relation to first phase insulin response (FPIR) and glucose tolerance in autoimmune thyroid diseases (ATDs) patients. Subjects and methods: Graves' disease (GD; n = 181) and Hashimoto's thyroiditis (HT; n = 143) patients in addition to healthy controls (n = 93) were studied. Secondly, FPIR and oral glucose tolerance tests (OGTT) were performed in 11 anti-pancreatic islet-cell (+) and in 20 anti-pancreatic-cell (-) patients...
July 13, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28721933/transient-lesions-of-the-splenium-of-the-corpus-callosum-following-rapid-withdrawal-of-levetiracetam
#16
Ryo Sawagashira, Hisashi Narita, Naoki Hashimoto, Tsugiko Kurita, Shin Nakagawa, Takuya Saitoh, Ichiro Kusumi
Transient lesions of the splenium of the corpus callosum are characterized by MRI findings. The lesions are very rare, but significant from a clinical standpoint as differential diagnoses include serious conditions such as encephalitis, meningitis, and neuroleptic malignant syndrome. In addition, it is reported that some are attributed to the withdrawal of antiepileptic drugs. Here, we present a case of transient lesions of the splenium of the corpus callosum following rapid withdrawal of levetiracetam alone...
July 19, 2017: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/28721130/premature-ovarian-failure
#17
REVIEW
Katarzyna Jankowska
Premature ovarian failure (POF) is the term usually used to describe women aged younger than 40 years, who present with amenorrhoea, hypergonadotropic hypogonadism, and infertility. POF is a devastating diagnosis for reproductive-aged women. The clinical presentation is diverse, and several different disorders can lead to premature ovarian failure. POF has serious health consequences, including psychological distress, infertility, osteoporosis, autoimmune disorders, ischaemic heart disease, and increased risk of mortality...
June 2017: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28717394/immunohistochemical-expression-of-er-%C3%AE-and-pr-in-papillary-thyroid-carcinoma
#18
Marwa Mohammed Serag Eldien, Asmaa Gaber Abdou, Tarek Rageh, Eman Abdelrazek, Enas Elkholy
Papillary thyroid carcinoma (PTC) is the most common thyroid cancer with multiple risk factors including exposure to ionising radiation. Oestrogens contribute to papillary carcinoma development by promoting cell proliferation and invasion of mutated epithelial follicular cells. The present study aimed to assess ER-α and PR expression in PTC and to correlate their expression with the clinicopathological parameters in this cancer. This study included 62 primary and six metastatic papillary thyroid carcinoma cases...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28717058/lumbosacral-transitional-vertebrae-cause-spinal-level-misconception-in-surgeries-for-degenerative-lumbar-spine-disorders
#19
Tomowaki Nakagawa, Ko Hashimoto, Takumi Tsubakino, Takeshi Hoshikawa, Takashi Inawashiro, Yasuhisa Tanaka
Human lumbar spine usually consists of five vertebrae; however, some individuals have vertebral anomalies with four or six lumbar vertebrae because of sacralized fifth lumbar vertebra (L5 sacralization) or lumbarized first sacral vertebra (S1 lumbarization), respectively. These vertebral anomalies are called lumbosacral transitional vertebra (LSTV). Although LSTV is an asymptomatic anomaly, it is known to cause misconception in spinal counts and in spinal level at lumbar spinal surgery. The purpose of this study is to evaluate how LSTV affects the diagnosis and surgeries in lumbar spine disorders...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28715470/impairment-of-cold-injury-induced-muscle-regeneration-in-mice-receiving-a-combination-of-bone-fracture-and-alendronate-treatment
#20
Shigeo Kawada, Atsushi Harada, Naohiro Hashimoto
Alendronate, a nitrogen-containing bisphosphonate, is well established as a treatment for osteoporosis through regulation of osteoclast activity. Previously, the pharmacological effects of bisphosphonates on cells outside the bone environment have been considered irrelevant because bisphosphonates target bone. Here we show that administration of alendronate impairs muscle regeneration in mice after bone fracture. A series of injections of alendronate alone or bone fracture alone did not affect muscle regeneration induced by cold injury...
2017: PloS One
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