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canadian light source

Mayilee Canizares, Monique Gignac, Sheilah Hogg-Johnson, Richard H Glazier, Elizabeth M Badley
OBJECTIVE: In light of concerns for meeting the provision of healthcare services given the large numbers of ageing baby boomers, we compared the trajectories of primary care and specialist services use across the lifecourse of 5 birth cohorts and examined factors associated with birth cohort differences. DESIGN: Longitudinal panel. SETTING: Canadian National Population Health Survey (1994-2011). POPULATION: Sample of 10 186 individuals aged 20-69 years in 1994-1995 and who were from 5 birth cohorts: Generation X (Gen X; born: 1965-1974), Younger Baby Boomers (born: 1955-1964), Older Baby Boomers (born: 1945-1954), World War II (born: 1935-1944) and pre-World War II (born: 1925-1934)...
2016: BMJ Open
T W Wysokinski, J P Ianowski, X Luan, G Belev, D Miller, M A Webb, N Zhu, D Chapman
The BioMedical Imaging and Therapy (BMIT) facility [1,2] located at the Canadian Light Source, provides synchrotron-specific imaging and radiation therapy capabilities. There are two separate beamlines used for experiments: the bending magnet (05B1-1) and the insertion device (05ID-2) beamline. The bending magnet beamline provides access to monochromatic beam spanning a spectral range of 15-40keV, and the beam is 240mm wide in the POE-2 experimental hutch. Users can also perform experiments with polychromatic (pink) beam...
July 21, 2016: Physica Medica: PM
Arash Panahifar, Treena M Swanston, M Jake Pushie, George Belev, Dean Chapman, Lynn Weber, David M L Cooper
Bone is a dynamic tissue which exhibits complex patterns of growth as well as continuous internal turnover (i.e. remodeling). Tracking such changes can be challenging and thus a high resolution imaging-based tracer would provide a powerful new perspective on bone tissue dynamics. This is, particularly so if such a tracer can be detected in 3D. Previously, strontium has been demonstrated to be an effective tracer which can be detected by synchrotron-based dual energy K-edge subtraction (KES) imaging in either 2D or 3D...
June 20, 2016: Physics in Medicine and Biology
Naheda Sahtout, Jijin R A Kuttiyatveetil, Michel Fodje, David A R Sanders
Thioredoxin is a small ubiquitous protein that plays a role in many biological processes. A putative thioredoxin, Trx1, from Thermosipho africanus strain TCF52B, which has low sequence identity to its closest homologues, was successfully cloned, overexpressed and purified. The protein was crystallized using the microbatch-under-oil technique at 289 K in a variety of conditions; crystals grown in 0.2 M MgCl2, 0.1 M bis-tris pH 6.5, 25%(w/v) PEG 3350, which grew as irregular trapezoids to maximum dimensions of 1...
June 2016: Acta Crystallographica. Section F, Structural Biology Communications
Assem Hedayat, Nicole Nagy, Garnet Packota, Judy Monteith, Darcy Allen, Tomasz Wysokinski, Ning Zhu
Dental burs are used extensively in dentistry to mechanically prepare tooth structures for restorations (fillings), yet little has been reported on the bur debris left behind in the teeth, and whether it poses potential health risks to patients. Here it is aimed to image dental bur debris under dental fillings, and allude to the potential health hazards that can be caused by this debris when left in direct contact with the biological surroundings, specifically when the debris is made of a non-biocompatible material...
May 2016: Journal of Synchrotron Radiation
James E Montgomery, Michal J Wesolowski, Bailey Wolkowski, Rajni Chibbar, Elisabeth C R Snead, Jaswant Singh, Murray Pettitt, Pritpal S Malhi, Trinita Barboza, Gregg Adams
Prostatic urethral transitional cell carcinoma with prostatic invasion in a dog was imaged with abdominal radiography and abdominal ultrasonography antemortem. Synchrotron in-line x-ray phase contrast imaging computed tomography (XPCI-CT) was performed on the prostate ex vivo at the Canadian Light Source Synchrotron and compared to histology. XPCI-CT imaging provides greater soft tissue contrast than conventional absorption-based x-ray imaging modalities, permitting visualization of regions of inflammatory cell infiltration, differentiation of invasive versus noninvasive tumor regions, and areas of necrosis and mineralization...
January 2016: Journal of Medical Imaging
Kenneth B Gagnon, Sally Caine, Nazanin Samadi, Mercedes Martinson, Melanie van der Loop, Jane Alcorn, L Dean Chapman, George Belev, Helen Nichol
High-resolution computed tomography (CT) imaging of a live animal within a lead-lined synchrotron light hutch presents several unique challenges. In order to confirm that the animal is under a stable plane of anaesthesia, several physiological parameters (e.g. heart rate, arterial oxygen saturation, core body temperature and respiratory rate) must be remotely monitored from outside the imaging hutch. In addition, to properly scan the thoracic region using CT, the animal needs to be held in a vertical position perpendicular to the fixed angle of the X-ray beam and free to rotate 180°-360°...
September 2015: Journal of Synchrotron Radiation
JiaWei Wang, Lei Shang, Kelly Light, Jennifer O'Loughlin, Gilles Paradis, Katherine Gray-Donald
Little is known about the influence of different forms of added sugar intake on diet quality or their association with obesity among youth. Dietary intake was assessed by three 24-h recalls in 613 Canadian children (aged 8-10 years). Added sugars (mean of 3-day intakes) were categorized according to source (solid or liquid). Dietary intake and the Canadian Healthy Eating Index (« HEI-C ») were compared across tertiles of solid and liquid added sugars separately as were adiposity indicators (body mass index (BMI), fat mass (dual-energy X-ray absorptiometry), and waist circumference)...
August 2015: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Bailey Wolkowski, Elisabeth Snead, Michal Wesolowski, Jaswant Singh, Murray Pettitt, Rajni Chibbar, Seyedali Melli, James Montgomery
Synchrotron-based in-line phase-contrast computed tomography (PC-CT) allows soft tissue to be imaged with sub-gross resolution and has potential to be used as a diagnostic tool. The reconstruction and processing of in-line PC-CT datasets is a computationally demanding task; thus, an efficient and user-friendly software program is desirable. Four freeware programs (NRecon, PITRE, H-PITRE and Athabasca Recon) were compared for the availability of features such as dark- and flat-field calibration, beam power normalization, ring artifact removal, and alignment tools for optimizing image quality...
July 2015: Journal of Synchrotron Radiation
B E Billinghurst, J C Bergstrom, C Baribeau, T Batten, L Dallin, T E May, J M Vogt, W A Wurtz, R Warnock, D A Bizzozero, S Kramer
We report on high resolution measurements of resonances in the spectrum of coherent synchrotron radiation (CSR) at the Canadian Light Source (CLS). The resonances permeate the spectrum at wave number intervals of 0.074  cm(-1), and are highly stable under changes in the machine setup (energy, bucket filling pattern, CSR in bursting or continuous mode). Analogous resonances were predicted long ago in an idealized theory as eigenmodes of a smooth toroidal vacuum chamber driven by a bunched beam moving on a circular orbit...
May 22, 2015: Physical Review Letters
Mercedes Martinson, Nazanin Samadi, Bassey Bassey, Ariel Gomez, Dean Chapman
The BioMedical Imaging and Therapy beamlines at the Canadian Light Source are used by many researchers to capture phase-based imaging data. These experiments have so far been limited by the small vertical beam size, requiring vertical scanning of biological samples in order to image their full vertical extent. Previous work has been carried out to develop a bent Laue beam-expanding monochromator for use at these beamlines. However, the first attempts exhibited significant distortion in the diffraction plane, increasing the beam divergence and eliminating the usefulness of the monochromator for phase-related imaging techniques...
May 2015: Journal of Synchrotron Radiation
Changyun Xu, Scott J Weese, Azadeh Namvar, Keith Warriner
The study described in this article aimed at establishing a baseline assessment of the sanitary status of ice and guest rooms within Canadian hotels. Collectively, 54 hotel rooms belonging to six different national chains were sampled. High-contact surfaces (comforter, alarm clock, bedside lamp, TV remote, bathroom countertop, faucet, and toilet seat) were sampled using adenosine triphosphate (ATP) swabs and replicate organism detection and counting plates. ATP swab readings ranged from 2.12 to 4.42 log relative light units...
April 2015: Journal of Environmental Health
Ward Vanlaar, Heather McAteer, Steve Brown, Jennifer Crain, Steven McFaull, Marisela Mainegra Hing
Off-road vehicles (ORVs; this includes snowmobiles, all-terrain vehicles or ATVs and dirt bikes) were once used primarily for work and travel. Such use remains common in Canada, although their recreational use has also gained popularity in recent years. An epidemiological injury profile of ORV users is important for better understanding injuries and their risk factors to help inform injury prevention initiatives. The Traffic Injury Research Foundation (TIRF) partnered with the Public Health Agency of Canada (PHAC) to analyze the epidemiology of ORV-related injuries...
February 2015: Accident; Analysis and Prevention
I V Pratt, G Belev, N Zhu, L D Chapman, D M L Cooper
Cortical bone is a dynamic tissue which undergoes adaptive and pathological changes throughout life. Direct longitudinal tracking of this remodeling process holds great promise for improving our understanding of bone development, maintenance and senescence. The application of in vivo micro-computed tomography (micro-CT) has enabled longitudinal tracking of trabecular bone microarchitecture with commercially available scanners generally operating in the 10-20 µm voxel range with absorbed doses reported between 0...
January 7, 2015: Physics in Medicine and Biology
Steven W Duerksen, Gregory W Thiemann, Suzanne M Budge, Michel Poulin, Andrea Niemi, Christine Michel
Pelagic primary production in Arctic seas has traditionally been viewed as biologically insignificant until after the ice breakup. There is growing evidence however, that under-ice blooms of pelagic phytoplankton may be a recurrent occurrence. During the springs of 2011 and 2012, we found substantial numbers (201-5713 cells m-3) of the large centric diatom (diameter >250 µm) Coscinodiscus centralis under the sea ice in the Canadian Arctic Archipelago near Resolute Bay, Nunavut. The highest numbers of these pelagic diatoms were observed in Barrow Strait...
2014: PloS One
B Diaz, A Gomez, B Meyer, A Duffy, E Hallin, S Kycia
The Brockhouse project at the Canadian Light Source plans the construction of three beamlines, two wiggler beamlines, and one undulator beamline, that will be dedicated to x-ray diffraction and scattering. In this work, we will describe the undulator beamline main components and performance parameters, obtained from ray tracing using XOP-SHADOW codes. The undulator beamline will operate from 4.95 to 21 keV, using a 20 mm period hybrid undulator placed upstream of the wiggler in the same straight section. The beamline optics design was developed in cooperation with the Brazilian Synchrotron - LNLS...
August 2014: Review of Scientific Instruments
Manfred Winnewisser, Brenda P Winnewisser, Frank C De Lucia, Dennis W Tokaryk, Stephen C Ross, Brant E Billinghurst
Quantum monodromy has a dramatic and defining impact on all those physical properties of chain-molecules that depend on a large-amplitude bending coordinate, including in particular the distribution of the ro-vibrational energy levels. As revealed by its pure rotational (a-type) spectrum [B. P. Winnewisser et al., Phys. Chem. Chem. Phys., 2010, 12, 8158-8189] cyanogen iso-thiocyanate, NCNCS, is a particularly illuminating exemplar of quantum monodromy: it clearly shows the distinctive monodromy-induced dislocation of the ro-vibrational energy level pattern for its low-lying bending mode...
September 7, 2014: Physical Chemistry Chemical Physics: PCCP
Shelly Benjaminy, Tania Bubela
BACKGROUND: Ocular gene transfer clinical trials are raising hopes for blindness treatments and attracting media attention. News media provide an accessible health information source for patients and the public, but are often criticized for overemphasizing benefits and underplaying risks of novel biomedical interventions. Overly optimistic portrayals of unproven interventions may influence public and patient expectations; the latter may cause patients to downplay risks and over-emphasize benefits, with implications for informed consent for clinical trials...
2014: BMC Medical Ethics
Michel Fodje, Pawel Grochulski, Kathryn Janzen, Shaunivan Labiuk, James Gorin, Russ Berg
Beamline 08B1-1 is a recently commissioned bending-magnet beamline at the Canadian Light Source. The beamline is designed for automation and remote access. Together with the undulator-based beamline 08ID-1, they constitute the Canadian Macromolecular Crystallography Facility. This paper describes the design, specifications, hardware and software of beamline 08B1-1. A few scientific results using data obtained at the beamline will be highlighted.
May 2014: Journal of Synchrotron Radiation
Mercedes Martinson, Nazanin Samadi, George Belev, Bassey Bassey, Rob Lewis, Gurpreet Aulakh, Dean Chapman
The Biomedical Imaging and Therapy (BMIT) beamline at the Canadian Light Source has produced some excellent biological imaging data. However, the disadvantage of a small vertical beam limits its usability in some applications. Micro-computed tomography (micro-CT) imaging requires multiple scans to produce a full projection, and certain dynamic imaging experiments are not possible. A larger vertical beam is desirable. It was cost-prohibitive to build a longer beamline that would have produced a large vertical beam...
May 2014: Journal of Synchrotron Radiation
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