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Crp utuc

Teruo Inamoto, Hideyasu Matsuyama, Shigeru Sakano, Naokazu Ibuki, Kiyoshi Takahara, Kazumasa Komura, Tomoaki Takai, Takuya Tsujino, Yuki Yoshikawa, Koichiro Minami, Kazuhiro Nagao, Ryo Inoue, Haruhito Azuma
Introduction and Objective: The combination of C-reactive protein and albumin, the Glasgow Prognostic Score (GPS), had independent prognostic value in patients with varying cancers, except for upper tract urothelial carcinoma (UTUC). The aim of this study was to describe the relationship between GPS and survival in patients with UTUC after adjustment for other prognostic factors. Materials and Methods: We queried 2 UTUC databases. Retrospective clinical series on patients with localized UTUC managed by nephroureterectomy with bladder cuff, for whom data from the Yamaguchi Uro-Oncology Group and Osaka Medical College registry, including age, presence of bladder cancer, pT stage, lymphovascular invasion, C-reactive protein (CRP) and albumin, were analyzed...
December 22, 2017: Oncotarget
You Luo, Sheng Jun Fu, Dong Li She, H U Xiong, L I Yang
Upper tract urothelial carcinoma (UTUC) is a relatively rare and highly aggressive tumor. However, the prognosis of UTUC is rarely predicted accurately due to the lack of reliable biomarkers. C-reactive protein (CRP) has been found to be correlated with several types of cancer. In this study, we performed a systematic review and meta-analysis to determine the association between CRP levels and prognosis in UTUC. A computerized search was conducted through PubMed, Embase, Web of Science, the Cochrane Library and CBM databases to identify clinical studies that have evaluated the association between preoperative CRP levels and prognosis of UTUC...
July 2015: Molecular and Clinical Oncology
Shuichi Morizane, Tetsuya Yumioka, Noriya Yamaguchi, Toshihiko Masago, Masashi Honda, Takehiro Sejima, Atsushi Takenaka
PURPOSE: To investigate the prognostic indicators, including clinicopathological and preoperative hematological factors, in patients undergoing radical nephroureterectomy (RNU) for upper urinary tract urothelial carcinoma (UTUC), and to develop a prognostic factor-based risk stratification model. METHODS: The clinicopathological data and preoperative parameters were collected from 345 UTUC patients treated with RNU without neoadjuvant therapy, retrospectively. The prognostic values of preoperative hematological parameters and clinicopathological factors were evaluated...
August 2015: International Urology and Nephrology
P Colin, J Irani, S J Drouin, S F Shariat, M Rouprêt
AIM: To describe the main prognostic factors with an impact on survival of patients diagnosed with upper tract urothelial carcinomas (UTUC). MATERIAL AND METHODS: A systematic review of the literature has been performed using Pubmed without timeline restriction with the following keywords (MeSH): urothelial carcinoma; ureter; renal pelvis; prognosis; recurrence; survival; predictive models; nomogram. RESULTS: The level of evidence was low (3) in every available studies...
November 2014: Progrès en Urologie
Atiqullah Aziz, Michael Rink, Georgios Gakis, Luis A Kluth, Christopher Dechet, Florian Miller, Wolfgang Otto, Michael Gierth, Stefan Denzinger, Christian Schwentner, Arnulf Stenzl, Margit Fisch, Maximilian Burger, Hans-Martin Fritsche
OBJECTIVE: To investigate the impact of preoperative serum C-reactive protein (CRP) on clinicopathological features and prognosis in patients with upper tract urothelial cancer (UTUC) after radical nephroureterectomy (RNU). PATIENTS AND METHODS: Data of 265 patients from three German centers who underwent RNU for UTUC without neoadjuvant chemotherapy between 1990 and 2012 were evaluated. Mean follow-up was 37 months (interquartile range 9-48). CRP was analyzed as a categorical and continuous variable for the prediction of recurrence-free survival (RFS), disease-specific survival (DSS) and all-cause survival (ACS) using uni- and multivariate Cox regression analyses...
2014: Urologia Internationalis
Yang Hyun Cho, Young Ho Seo, Seung Jun Chung, Insang Hwang, Ho Song Yu, Sun-Ouck Kim, Seung Il Jung, Taek Won Kang, Dong Deuk Kwon, Kwangsung Park, Jun Eul Hwang, Suk Hee Heo, Geun Soo Kim, Eu Chang Hwang
PURPOSE: Systemic inflammatory responses, which are defined in terms of the Glasgow prognostic score (GPS), have been reported to be independent predictors of unfavorable outcomes in various human cancers. We assessed the utility of the GPS as a predictor of intravesical recurrence after radical nephroureterectomy (RNU) in upper urinary tract carcinoma (UTUC). MATERIALS AND METHODS: We collected data for 147 UTUC patients with no previous history of bladder cancer who underwent RNU from 2004 to 2012...
July 2014: Korean Journal of Urology
Kazutoshi Fujita, Motohide Uemura, Yoshiyuki Yamamoto, Go Tanigawa, Wataru Nakata, Mototaka Sato, Akira Nagahara, Hiroshi Kiuchi, Yasutomo Nakai, Kiyomi Matsumiya, Seiji Yamaguchi, Norio Nonomura
BACKGROUND: This study aimed to identify preoperative parameters for predicting cancer-specific survival (CSS) in patients with upper urinary tract urothelial carcinoma (UTUC) who have undergone radical nephroureterectomy (RNU). METHODS: The preoperative clinical and laboratory records of 357 UTUC patients who underwent RNU at three different institutions were retrospectively reviewed (256, training set; 101, test set). Univariate and multivariate analyses were performed on the training set data to identify preoperative prognostic factors, using which a risk stratification model was developed...
February 2015: International Journal of Clinical Oncology
Nobuyuki Tanaka, Eiji Kikuchi, Suguru Shirotake, Kent Kanao, Kazuhiro Matsumoto, Hiroaki Kobayashi, Yasumasa Miyazaki, Hiroki Ide, Jun Obata, Katsura Hoshino, Nozomi Hayakawa, Yujiro Ito, Takeo Kosaka, Kiichiro Kodaira, Masafumi Oyama, Akira Miyajima, Tetsuo Momma, Ken Nakagawa, Munehisa Ueno, Mototsugu Oya
BACKGROUND: Few studies have discussed the prognostic impact of serum C-reactive protein (CRP) level in upper tract urothelial carcinoma (UTUC). OBJECTIVE: To investigate whether the perioperative level of CRP provides additional prognostic information following radical nephroureterectomy (RNU). DESIGN, SETTING, AND PARTICIPANTS: A total of 564 patients with UTUC from a retrospective multi-institutional cohort were included. The median follow-up was 32 mo...
January 2014: European Urology
Jun Obata, Eiji Kikuchi, Nobuyuki Tanaka, Kazuhiro Matsumoto, Nozomi Hayakawa, Hiroki Ide, Akira Miyajima, Ken Nakagawa, Mototsugu Oya
BACKGROUND AND OBJECTIVE: Serum C-reactive protein (CRP) is one particular marker of systemic inflammation, and an elevated CRP level is associated with poor outcome in various malignancies. While the clinical value of CRP levels in upper tract urothelial carcinoma (UTUC) has not yet been fully evaluated, we investigated the impact of CRP elevation as a biomarker of patient prognosis in UTUC. MATERIALS AND METHODS: A total of 183 patients who underwent radical nephroureterectomy (RNU) for localized UTUC (pTa-4N0M0) were identified between 1993 and 2009...
November 2013: Urologic Oncology
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