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Posterior cortical atrophy

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https://www.readbyqxmd.com/read/29614676/regional-distribution-asymmetry-and-clinical-correlates-of-tau-uptake-on-18f-av-1451-pet-in-atypical-alzheimer-s-disease
#1
Katerina A Tetzloff, Jonathan Graff-Radford, Peter R Martin, Nirubol Tosakulwong, Mary M Machulda, Joseph R Duffy, Heather M Clark, Matthew L Senjem, Christopher G Schwarz, Anthony J Spychalla, Daniel A Drubach, Clifford R Jack, Val J Lowe, Keith A Josephs, Jennifer L Whitwell
BACKGROUND: Despite common pathology, Alzheimer's disease (AD) can have multiple clinical presentations which pathological studies suggest result from differences in the regional distribution of tau pathology. Positron emission tomography (PET) ligands are now available that can detect tau proteins in vivo and hence can be used to investigate the biological mechanisms underlying atypical AD. OBJECTIVE: To assess regional patterns of tau uptake on PET imaging in two atypical AD variants, posterior cortical atrophy (PCA) and logopenic progressive aphasia (lvPPA)...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29610105/cortical-thinning-and-cognitive-impairment-in-parkinson-s-disease-without-dementia
#2
Lijun Zhang, Ming Wang, Nicholas W Sterling, Eun-Young Lee, Paul J Eslinger, Daymond Wagner, Guangwei Du, Mechelle M Lewis, Young Truong, F DuBois Bowman, Xuemei Huang
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized clinically by motor dysfunction (bradykinesia, rigidity, tremor, and postural instability), and pathologically by the loss of dopaminergic neurons in the substantia nigra of the basal ganglia. Growing literature supports that cognitive deficits may also be present in PD, even in non-demented patients. Gray matter (GM) atrophy has been reported in PD and may be related to cognitive decline. This study investigated cortical thickness in non-demented PD subjects and elucidated its relationship to cognitive impairment using high-resolution T1-weighted brain MRI and comprehensive cognitive function scores from 71 non-demented PD and 48 control subjects matched for age, gender, and education...
March 2018: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/29574441/lifestyle-and-vascular-risk-effects-on-mri-based-biomarkers-of-alzheimer-s-disease-a-cross-sectional-study-of-middle-aged-adults-from-the-broader-new-york-city-area
#3
Lisa Mosconi, Michelle Walters, Joanna Sterling, Crystal Quinn, Pauline McHugh, Randolph E Andrews, Dawn C Matthews, Christine Ganzer, Ricardo S Osorio, Richard S Isaacson, Mony J De Leon, Antonio Convit
OBJECTIVE: To investigate the effects of lifestyle and vascular-related risk factors for Alzheimer's disease (AD) on in vivo MRI-based brain atrophy in asymptomatic young to middle-aged adults. DESIGN: Cross-sectional, observational. SETTING: Broader New York City area. Two research centres affiliated with the Alzheimer's disease Core Center at New York University School of Medicine. PARTICIPANTS: We studied 116 cognitively normal healthy research participants aged 30-60 years, who completed a three-dimensional T1-weighted volumetric MRI and had lifestyle (diet, physical activity and intellectual enrichment), vascular risk (overweight, hypertension, insulin resistance, elevated cholesterol and homocysteine) and cognition (memory, executive function, language) data...
March 23, 2018: BMJ Open
https://www.readbyqxmd.com/read/29570898/novel-connectivity-map-normalization-procedure-for-improved-quantitative-investigation-of-structural-thalamic-connectivity-in-temporal-lobe-epilepsy-patients
#4
Brendan G Santyr, Jonathan C Lau, Seyed M Mirsattari, Jorge G Burneo, Sandrine de Ribaupierre, David A Steven, Andrew G Parrent, Keith MacDougall, Ali R Khan
BACKGROUND: Connectivity studies targeting the thalamus have revealed patterns of atrophy and deafferentiation in temporal lobe epilepsy (TLE). The thalamus can be parcellated using probabilistic tractography to demonstrate regions of cortical connectivity; however, sensitivity to smaller or less connected regions is low. PURPOSE/HYPOTHESIS: To investigate thalamic structural connectivity in a wider range of cortical and limbic structures in TLE patients using a novel connectivity map normalization procedure...
March 23, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29569567/posterior-cortical-atrophy-from-vision-to-emotion
#5
Maxime Montembeault, Lucette Lacomblez, Marie-Odile Habert, Aurélie Kas, Raffaella Migliaccio
In this review of the literature on posterior cortical atrophy (PCA), the history of the disease is first told through the studies of Frank Benson and Oliver Sacks. Then, we detail the possible underlying pathologies, Alzheimer's disease being the most common cause. Clinical, cognitive, and biological features are described, with a specific focus on the neuroimaging. We also describe the emotional aspects of PCA. These aspects are often overlooked, but deserve a particular attention due to their impact on the quality of life and prognostic implications for the patients...
March 1, 2018: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/29449187/cortical-atrophy-patterns-in-early-parkinson-s-disease-patients-using-hierarchical-cluster-analysis
#6
Carme Uribe, Barbara Segura, Hugo Cesar Baggio, Alexandra Abos, Anna Isabel Garcia-Diaz, Anna Campabadal, Maria Jose Marti, Francesc Valldeoriola, Yaroslau Compta, Eduard Tolosa, Carme Junque
INTRODUCTION: Cortical brain atrophy detectable with MRI in non-demented advanced Parkinson's disease (PD) is well characterized, but its presence in early disease stages is still under debate. We aimed to investigate cortical atrophy patterns in a large sample of early untreated PD patients using a hypothesis-free data-driven approach. METHODS: Seventy-seven de novo PD patients and 50 controls from the Parkinson's Progression Marker Initiative database with T1-weighted images in a 3-tesla Siemens scanner were included in this study...
February 8, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29439072/-because-my-brain-isn-t-as-active-as-it-should-be-my-eyes-don-t-always-see-a-qualitative-exploration-of-the-stress-process-for-those-living-with-posterior-cortical-atrophy
#7
Emma Harding, Mary Pat Sullivan, Rachel Woodbridge, Keir X X Yong, Anne McIntyre, Mary L Gilhooly, Kenneth J Gilhooly, Sebastian J Crutch
OBJECTIVES: To explore the stress process for individuals living with posterior cortical atrophy (PCA) and their families. DESIGN: A qualitative study using in-depth semi-structured dyadic and individual interviews with people living with a diagnosis of PCA and a family carer. Interview transcripts were thematically analysed. SETTING: Participants' homes. PARTICIPANTS: 20 individuals in the mild to moderate stages of PCA and 20 family carers...
February 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/29437810/down-syndrome-with-posterior-cortical-atrophy
#8
Claire Boutoleau-Bretonnière, Amandine Pallardy
Down syndrome (DS) is caused by trisomy of chromosome 21. The average age of onset of Alzheimer's disease (AD) ranged from 50 to 55 years in DS, with early symptoms usually characterised by changes in behaviour and executive dysfunction. On the other hand, posterior cortical atrophy (PCA) is a rare neurodegenerative syndrome characterised by progressive impairment of visual functions in the absence of visual deficits and a pattern of atrophy involving posterior cortex. This syndrome is mostly caused by AD pathology...
February 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29436943/heterozygous-genotype-at-codon-129-correlates-with-prolonged-disease-course-in-heidenhain-variant-sporadic-cjd-case-report
#9
Ryan A Townley, Elliot T Dawson, Daniel A Drubach
Sporadic Creutzfeldt-Jakob disease (sCJD) is a rapid and fatal neurodegenerative disease defined by misfolded prion proteins accumulating in the brain. A minority of cases initially present with posterior cortical atrophy (PCA) phenotype, also known as Heidenhain variant or visual variant CJD. This case provides further evidence of sCJD presenting as PCA. The case also provides evidence for early DWI changes and cortical atrophy over 30 months before neurologic decline and subsequent death. The prolonged disease course correlates with prion protein codon 129 heterozygosity and coexistence of multiple prion strains...
February 2018: Neurocase
https://www.readbyqxmd.com/read/29422846/statokinetic-dissociation-riddoch-phenomenon-in-a-patient-with-homonymous-hemianopsia-as-the-first-sign-of-posterior-cortical-atrophy
#10
Ryuichiro Hayashi, Shigeki Yamaguchi, Toshio Narimatsu, Hiroshi Miyata, Yasushi Katsumata, Masaru Mimura
We report a 60-year-old woman with posterior cortical atrophy (PCA) who presented with left homonymous hemianopsia persisting for 5 years; the patient's condition was observed using static, but not kinetic, perimetry. This statokinetic dissociation of hemianopsia, which is often called Riddoch syndrome, might have been caused by a dysfunction of the right primary visual and visual association cortices, representing a functional imbalance within a disturbed visual cortex. In patients with PCA and visual field defects, both static and kinetic perimetry may be useful for understanding the extent of degeneration in the visual cortex, in addition to examinations of unilateral neglect...
September 2017: Case Reports in Neurology
https://www.readbyqxmd.com/read/29406908/extrastriatal-degeneration-correlates-with-deficits-in-the-motor-domain-subscales-of-the-uhdrs
#11
Victor Galvez, Gabriel Ramírez-García, Carlos R Hernandez-Castillo, Leo Bayliss, Rosalinda Díaz, María Margarita Lopez-Titla, Aurelio Campos-Romo, Juan Fernandez-Ruiz
INTRODUCTION: Striatal degeneration has significant behavioral effects in patients with Huntington's disease (HD). However, there is scant evidence of the possible contribution of extrastriatal regions to the motor alterations assessed within the different domains of the Unified Huntington's Disease Rating Scale (UHDRS). OBJECTIVE: Analyze if extrastriatal grey matter decrease in patients with HD correlates with motor performance assessed with the UHDRS and its different domains...
February 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29387532/fdg-pet-and-csf-biomarker-accuracy-in-prediction-of-conversion-to-different-dementias-in-a-large-multicentre-mci-cohort
#12
Silvia Paola Caminiti, Tommaso Ballarini, Arianna Sala, Chiara Cerami, Luca Presotto, Roberto Santangelo, Federico Fallanca, Emilia Giovanna Vanoli, Luigi Gianolli, Sandro Iannaccone, Giuseppe Magnani, Daniela Perani
Background/aims: In this multicentre study in clinical settings, we assessed the accuracy of optimized procedures for FDG-PET brain metabolism and CSF classifications in predicting or excluding the conversion to Alzheimer's disease (AD) dementia and non-AD dementias. Methods: We included 80 MCI subjects with neurological and neuropsychological assessments, FDG-PET scan and CSF measures at entry, all with clinical follow-up. FDG-PET data were analysed with a validated voxel-based SPM method...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29381890/tau-positron-emission-tomography-imaging-in-degenerative-parkinsonisms
#13
REVIEW
Chul Hyoung Lyoo, Hanna Cho, Jae Yong Choi, Young Hoon Ryu, Myung Sik Lee
In recent years, several radiotracers that selectively bind to pathological tau proteins have been developed. Evidence is emerging that binding patterns of in vivo tau positron emission tomography (PET) studies in Alzheimer's disease (AD) patients closely resemble the distribution patterns of known neurofibrillary tangle pathology, with the extent of tracer binding reflecting the clinical and pathological progression of AD. In Lewy body diseases (LBD), tau PET imaging has clearly revealed cortical tau burden with a distribution pattern distinct from AD and increased cortical binding within the LBD spectrum...
January 2018: Journal of Movement Disorders
https://www.readbyqxmd.com/read/29372599/clinical-significance-of-cognitive-rehabilitation-and-psychoeducational-intervention-for-family-caregivers-of-patients-with-posterior-cortical-atrophy-a-longitudinal-study
#14
Hiroshi Tatsumi, Masahiko Yamamoto, Keizo Yasui, Tatsuya Miyake
No abstract text is available yet for this article.
January 2018: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/29367598/cerebral-perfusion-insufficiency-and-relationships-with-cognitive-deficits-in-alzheimer-s-disease-a-multiparametric-neuroimaging-study
#15
Chi-Wei Huang, Shih-Wei Hsu, Ya-Ting Chang, Shu-Hua Huang, Yung-Cheng Huang, Chen-Chang Lee, Wen-Neng Chang, Chun-Chung Lui, Na-Ching Chen, Chiung-Chih Chang
Micro- or macro-circulatory insufficiency has a negative impact in patients with Alzheimer's disease (AD). This study used arterial spin-labeled magnetic resonance imaging (ASL-MRI) and ethylcysteinate dimer single-photon emission computed tomography (ECD-SPECT) in 50 patients with AD and 30 age-matched controls to investigate how hypoperfusion patterns were associated with gray matter atrophy and clinical data. All participants completed 3DT1-MRI, ECD-SPECT and ASL-MRI examinations. Medial temporal cortex (MTC) volumes were correlated with regional signals showing significantly lower relative cerebral blood flow (rCBF) in ASL-MRI or perfusion index (PI) in ECD-SPECT...
January 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321969/the-two-year-progression-of-structural-and-functional-cerebral-mri-in-amyotrophic-lateral-sclerosis
#16
R A L Menke, M Proudfoot, K Talbot, M R Turner
MRI has emerged as one of several urgently needed candidate disease progression biomarkers for the neurodegenerative disorder amyotrophic lateral sclerosis (ALS), not least due to its unique ability to non-invasively assess structural and functional cerebral pathology. We sought to identify the extent of detectable change in cerebral MRI metrics over a more prolonged period. Analysis of multi-modal MRI data was performed in a cohort of sixteen patients (13 ALS and 3 with primary lateral sclerosis) in whom it was possible to acquire six-monthly images over two years...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29312879/posterior-cortical-atrophy-the-value-of-neuroimaging-in-assessing-memory-loss
#17
Stefanos Ioannidis, Helam Roseman, Kenneth Chan, Stephane Duckett, Ruth Mizoguchi
No abstract text is available yet for this article.
December 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29309600/effect-of-cholinergic-treatment-depends-on-cholinergic-integrity-in-early-alzheimer-s-disease
#18
Nils Richter, Nora Beckers, Oezguer A Onur, Markus Dietlein, Marc Tittgemeyer, Lutz Kracht, Bernd Neumaier, Gereon R Fink, Juraj Kukolja
In early Alzheimer's disease, which initially presents with progressive loss of short-term memory, neurodegeneration especially affects cholinergic neurons of the basal forebrain. Pharmacotherapy of Alzheimer's disease therefore often targets the cholinergic system. In contrast, cholinergic pharmacotherapy of mild cognitive impairment is debated since its efficacy to date remains controversial. We here investigated the relationship between cholinergic treatment effects and the integrity of the cholinergic system in mild cognitive impairment due to Alzheimer's disease...
January 4, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29309541/fibre-specific-white-matter-reductions-in-alzheimer-s-disease-and-mild-cognitive-impairment
#19
Remika Mito, David Raffelt, Thijs Dhollander, David N Vaughan, J-Donald Tournier, Olivier Salvado, Amy Brodtmann, Christopher C Rowe, Victor L Villemagne, Alan Connelly
Alzheimer's disease is increasingly considered a large-scale network disconnection syndrome, associated with progressive aggregation of pathological proteins, cortical atrophy, and functional disconnections between brain regions. These pathological changes are posited to arise in a stereotypical spatiotemporal manner, targeting intrinsic networks in the brain, most notably the default mode network. While this network-specific disruption has been thoroughly studied with functional neuroimaging, changes to specific white matter fibre pathways within the brain's structural networks have not been closely investigated, largely due to the challenges of modelling complex white matter structure...
January 4, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29308699/posterior-cortical-atrophy-a-single-case-cognitive-and-radiological-follow-up
#20
Sol Esteves, Diana Andrea Ramirez Romero, Teresa Torralva, Macarena Martínez Cuitiño, Shannon Herndon, Blas Couto, Agustín Ibañez, Facundo Manes, María Roca
Posterior cortical atrophy (PCA) is a rare neurodegenerative syndrome characterized by initial predominant visuoperceptual deficits followed by a progressive decline in other cognitive functions. This syndrome has not been as thoroughly described as other dementias, particularly from a neuropsychological evolution perspective with only a few studies describing the evolution of its cognitive progression. In this investigation we review the literature on this rare condition and we perform a 7-year neuropsychological and neuroradiological follow-up of a 64-year-old man with PCA...
February 2018: Neurocase
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