keyword
https://read.qxmd.com/read/38513367/high-intensity-interval-training-combining-rowing-and-cycling-improves-but-does-not-restore-beta-cell-function-in-type-2-diabetes
#21
JOURNAL ARTICLE
Maria Houborg Petersen, Jacob Volmer Stidsen, Martin Eisemann de Almeida, Emil Kleis Wentorf, Kurt Jensen, Niels Ørtenblad, Kurt Højlund
AIMS: We investigated whether a high-intensity interval training (HIIT)-protocol could restore beta-cell function in type 2 diabetes compared with sedentary obese and lean individuals. MATERIALS AND METHODS: In patients with type 2 diabetes, and age-matched, glucose-tolerant obese and lean controls, we examined the effect of 8-weeks of supervised HIIT combining rowing and cycling on the acute (first-phase) and second-phase insulin responses, beta-cell function adjusted for insulin sensitivity (disposition index) and serum free fatty acid (FFA) levels using the Botnia clamp (1-h IVGTT followed by 3-h hyperinsulinemic-euglycemic clamp)...
March 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38510527/berberine-modulates-cardiovascular-diseases-as-a-multitarget-mediated-alkaloid-with-insights-into-its-downstream-signals-using-in-silico-prospective-screening-approaches
#22
JOURNAL ARTICLE
Sanaa Almowallad, Rehab Al-Massabi
Atherosclerosis is potentially correlated with several cardiac disorders that are greatly associated with cellular oxidative stress generation, inflammation, endothelial cells dysfunction, and many cardiovascular complications. Berberine is a natural isoquinoline alkaloid compound that widely modulates pathogenesis of atherosclerosis through its different curative potentials. This in silico screening study was designed to confirm the potent restorative properties of berberine chloride as a multitarget-mediated alkaloid against the CVDs and their complications through screening, identifying, visualizing, and evaluating its binding models, affinities, and interactions toward several CVDs-related targets as direct and/or indirect-mediated signals via inhibiting cellular ER stress and apoptotic signals and activating autophagy pathway...
May 2024: Saudi Journal of Biological Sciences
https://read.qxmd.com/read/38509584/pdgfr%C3%AE-%C3%A2-%C3%A2-cell-hif2%C3%AE-is-dispensable-for-white-adipose-tissue-metabolic-remodeling-and-hepatic-lipid-accumulation-in-obese-mice
#23
JOURNAL ARTICLE
Tao Yao, Danni Wei, Xin Tian, Lin Zhao, Qiangyou Wan, Xiaoli Zhang, Juan Cai, Siqi Li, Bowen Diao, Suihan Feng, Bo Shan, Mengle Shao, Ying Wu
BACKGROUND: Obesity is associated with extensive white adipose tissue (WAT) expansion and remodeling. Healthy WAT expansion contributes to the maintenance of energy balance in the liver, thereby ameliorating obesity-related hepatic steatosis. Tissue-resident mesenchymal stromal cell populations, including PDGFRβ + perivascular cells, are increasingly recognized pivotal as determinants of the manner in which WAT expands. However, the full array of regulatory factors controlling WAT stromal cell functions remains to be fully elucidated...
March 20, 2024: Lipids in Health and Disease
https://read.qxmd.com/read/38505620/myocardin-reverses-insulin-resistance-and-ameliorates-cardiomyopathy-by-increasing-irs-1-expression-in-a-murine-model-of-lipodystrophy-caused-by-adipose-deficiency-of-vacuolar-h-atpase-v0d1-subunit
#24
JOURNAL ARTICLE
Wenlin Yuan, Hui Lin, Yuan Sun, Lihuan Liu, Meijuan Yan, Yujuan Song, Xiaofan Zhang, Xiangling Lu, Yipei Xu, Qiyue He, Kunfu Ouyang, Chenglin Zhang, Yong Pan, Yu Huang, Ying Li, Xifeng Lu, Jie Liu
Aim: Adipose tissue (AT) dysfunction that occurs in both obesity and lipodystrophy is associated with the development of cardiomyopathy. However, it is unclear how dysfunctional AT induces cardiomyopathy due to limited animal models available. We have identified vacuolar H+ -ATPase subunit Vo d1, encoded by Atp6v0d1 , as a master regulator of adipogenesis, and adipose-specific deletion of Atp6v0d1 ( Atp6v0d1 AKO ) in mice caused generalized lipodystrophy and spontaneous cardiomyopathy. Using this unique animal model, we explore the mechanism(s) underlying lipodystrophy-related cardiomyopathy...
2024: Theranostics
https://read.qxmd.com/read/38501107/comparison-of-the-effects-of-monounsaturated-fatty-acids-and-polyunsaturated-fatty-acids-on-the-lipotoxicity-of-islets
#25
JOURNAL ARTICLE
Wen Liu, Min Zhu, Jingyi Liu, Shan Su, Xin Zeng, Fudong Fu, Yanrong Lu, Zhiyong Rao, Younan Chen
BACKGROUND: Monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs) have been reported to combat saturated fatty acid (SFA)-induced cellular damage, however, their clinical effects on patients with metabolic diseases such as diabetes and hyperlipidemia are still controversial. Since comparative studies of the effects of these two types of unsaturated fatty acids (UFAs) are still limited. In this study, we aimed to compare the protective effects of various UFAs on pancreatic islets under the stress of SFA-induced metabolic disorder and lipotoxicity...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38500398/stem-cell-secretome-treatment-improves-whole-body-metabolism-reduces-adiposity-and-promotes-skeletal-muscle-function-in-aged-mice
#26
JOURNAL ARTICLE
Zachary J Fennel, Paul-Emile Bourrant, Anu Susan Kurian, Jonathan J Petrocelli, Naomi M M P de Hart, Elena M Yee, Sihem Boudina, Hans S Keirstead, Gabrielle Nistor, Scott A Greilach, Nicole C Berchtold, Thomas E Lane, Micah J Drummond
Aging coincides with the progressive loss of muscle mass and strength, increased adiposity, and diminished physical function. Accordingly, interventions aimed at improving muscle, metabolic, and/or physical health are of interest to mitigate the adverse effects of aging. In this study, we tested a stem cell secretome product, which contains extracellular vesicles and growth, cytoskeletal remodeling, and immunomodulatory factors. We examined the effects of 4 weeks of 2×/week unilateral intramuscular secretome injections (quadriceps) in ambulatory aged male C57BL/6 mice (22-24 months) compared to saline-injected aged-matched controls...
March 18, 2024: Aging Cell
https://read.qxmd.com/read/38500280/interferon-upregulation-associates-with-insulin-resistance-in-humans
#27
JOURNAL ARTICLE
Maria M Adeva-Andany, Natalia Carneiro-Freire, Elvira Castro-Quintela, Eva Ameneiros-Rodriguez, Lucia Adeva-Contreras, Carlos Fernandez-Fernandez
In humans, insulin resistance is a physiological response to infections developed to supply sufficient energy to the activated immune system. This metabolic adaptation facilitates the immune response but usually persists after the recovery period of the infection and predisposes the hosts to type 2 diabetes and vascular injury. In patients with diabetes, superimposed insulin resistance worsens metabolic control and promotes diabetic ketoacidosis. Pathogenic mechanisms underlying insulin resistance during microbial invasions remain to be fully defined...
March 18, 2024: Current Diabetes Reviews
https://read.qxmd.com/read/38496841/-coreopsis-tinctoria-improves-energy-metabolism-in-obese-hyperglycemic-mice
#28
JOURNAL ARTICLE
Bingxin Huangfu, Minglan Yang, Jia Xu, Ruxin Gao, Yanzhou Hu, Yijia Zhao, Kunlun Huang, Xiaoyun He
Coreopsis tinctoria (CT) improves energy metabolism. However, the role of CT in alleviating obesity-induced hyperglycemia by targeting the liver remains unknown. Therefore, this article aims to explore the mechanism by which CT improves energy metabolism and resists hyperglycemia. The water and ethanol extracts of CT were administered to high-fat diet-induced (HFD) obese C57BL/6J mice at a dose of 4 g/kg.bw (low-dose water extract, WL; low-dose ethanol extract, EL) or 10 g/kg.bw (high-dose water extract, WH; high-dose ethanol extract, EH)...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38496495/off-target-depletion-of-plasma-tryptophan-by-allosteric-inhibitors-of-bckdk
#29
Caitlyn E Bowman, Michael D Neinast, Cholsoon Jang, Jiten Patel, Megan C Blair, Emily T Mirek, William O Jonsson, Qingwei Chu, Lauren Merlo, Laura Mandik-Nayak, Tracy G Anthony, Joshua D Rabinowitz, Zolt Arany
The activation of branched chain amino acid (BCAA) catabolism has garnered interest as a potential therapeutic approach to improve insulin sensitivity, enhance recovery from heart failure, and blunt tumor growth. Evidence for this interest relies in part on BT2, a small molecule that promotes BCAA oxidation and is protective in mouse models of these pathologies. BT2 and other analogs allosterically inhibit branched chain ketoacid dehydrogenase kinase (BCKDK) to promote BCAA oxidation, which is presumed to underlie the salutary effects of BT2...
March 10, 2024: bioRxiv
https://read.qxmd.com/read/38494876/cost-effectiveness-of-closed-loop-automated-insulin-delivery-using-the-cambridge-hybrid-algorithm-in-children-and-adolescents-with-type-1-diabetes-results-from-a-multicenter-6-month-randomized-trial
#30
JOURNAL ARTICLE
D Steven Fox, Julia Ware, Charlotte K Boughton, Janet M Allen, Malgorzata E Wilinska, Martin Tauschmann, Louise Denvir, Ajay Thankamony, Fiona Campbell, R Paul Wadwa, Bruce A Buckingham, Nikki Davis, Linda A DiMeglio, Nelly Mauras, Rachel E J Besser, Atrayee Ghatak, Stuart A Weinzimer, Lauren Kanapka, Craig Kollman, Judy Sibayan, Roy W Beck, Korey K Hood, Roman Hovorka
BACKGROUND/OBJECTIVE: The main objective of this study is to evaluate the incremental cost-effectiveness (ICER) of the Cambridge hybrid closed-loop automated insulin delivery (AID) algorithm versus usual care for children and adolescents with type 1 diabetes (T1D). METHODS: This multicenter, binational, parallel-controlled trial randomized 133 insulin pump using participants aged 6 to 18 years to either AID (n = 65) or usual care (n = 68) for 6 months. Both within-trial and lifetime cost-effectiveness were analyzed...
March 17, 2024: Journal of Diabetes Science and Technology
https://read.qxmd.com/read/38493915/semaglutide-6-months-therapy-of-type-2-diabetes-mellitus-restores-adipose-progenitors-potential-to-develop-metabolically-active-adipocytes
#31
JOURNAL ARTICLE
I Stafeev, M Agareva, S Michurina, A Tomilova, E Shestakova, E Zubkova, M Sineokaya, E Ratner, M Menshikov, Ye Parfyonova, M Shestakova
BACKGROUND: Nowadays type 2 diabetes mellitus (T2DM) leads to population mortality growth. Today glucagon-like peptide type 1 receptor agonists (GLP-1 RA) are one of the most promising glucose-lowered drugs with anorexigenic and cardioprotective effects. The present study aims to determine the effects of GLP-1 RA semaglutide 6-month therapy on T2DM patient metabolic parameters and adipose progenitor cell health. METHODS: T2DM patients (N = 8) underwent clinical characterization and subcutaneous fat biopsy at start point and after semaglutide 6-month therapy...
March 15, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38493538/jaboticaba-peel-improves-postprandial-glucose-and-inflammation-a-randomized-controlled-trial-in-adults-with-metabolic-syndrome
#32
JOURNAL ARTICLE
Marina Vilar Geraldi, Ágatta Caroline de Souza, Marina Maintinguer Norde, Paulo Roberto Berni, Lívia Mateus Reguengo, Bruno Geloneze, Mario Roberto Marostica
The modulation of glucose metabolism through dietary sources has been recognized as 1 of the most sustainable approaches for preventing of cardiometabolic diseases. Although fibers and phenolic compounds derived from jaboticaba (Plinia jaboticaba) peel have demonstrated improvements in metabolic pathways in preclinical models, their beneficial effects in clinical trials remain to be fully determined. This study aimed to assess the impact of jaboticaba peel (JP) powder supplementation on glucose metabolism compared with a placebo in individuals with metabolic syndrome (MetS)...
February 28, 2024: Nutrition Research
https://read.qxmd.com/read/38491160/angiotensin-ii-type-2-receptor-signaling-facilitates-liver-injury-repair-and-regeneration-via-inactivation-of-hippo-pathway
#33
JOURNAL ARTICLE
Chang-Yong Xu, Ji Jiang, Yue An, Peng-Fei Ye, Cun-Cun Zhang, Ning-Ning Sun, Sai-Nan Miao, Meng-Qi Chai, Wen-Min Liu, Mei Yang, Wei-Hua Zhu, Jing-Jing Yu, Man-Man Yu, Wu-Yi Sun, Huan Qiu, Shi-Hao Zhang, Wei Wei
The angiotensin II type 2 receptor (AT2R) is a well-established component of the renin-angiotensin system and is known to counteract classical activation of this system and protect against organ damage. Pharmacological activation of the AT2R has significant therapeutic benefits, including vasodilation, natriuresis, anti-inflammatory activity, and improved insulin sensitivity. However, the precise biological functions of the AT2R in maintaining homeostasis in liver tissue remain largely unexplored. In this study, we found that the AT2R facilitates liver repair and regeneration following acute injury by deactivating Hippo signaling and that interleukin-6 transcriptionally upregulates expression of the AT2R in hepatocytes through STAT3 acting as a transcription activator binding to promoter regions of the AT2R...
March 15, 2024: Acta Pharmacologica Sinica
https://read.qxmd.com/read/38490239/abrus-precatorius-leaf-extract-stimulates-insulin-mediated-muscle-glucose-uptake-in-vitro-studies-and-phytochemical-analysis
#34
JOURNAL ARTICLE
Chintha Lankatillake, Tien Huynh, Daniel A Dias
Diabetes mellitus, linked with insulin resistance and hyperglycaemia, is a leading cause of mortality. Glucose uptake through glucose transporter type 4, especially in skeletal muscle, is crucial for maintaining euglycaemia and is a key pathway targeted by antidiabetic medication. Abrus precatorius is a medicinal plant with demonstrated antihyperglycaemic activity in animal models, but its mechanisms are unclear.This study evaluated the effect of a 50% ethanolic ( v/v ) A. precatorius leaf extract on (1) insulin-stimulated glucose uptake and (2) related gene expression in differentiated C2C12 myotubes using rosiglitazone as a positive control, and (3) generated a comprehensive phytochemical profile of A...
March 15, 2024: Planta Medica
https://read.qxmd.com/read/38487818/impact-of-breastfeeding-duration-on-coagulation-in-women-with-and-without-history-of-gestational-diabetes-mellitus
#35
JOURNAL ARTICLE
Louise Fritsche, Dorina Löffler, Konstantinos Kantartzis, Gesine Flehmig, Michael Roden, Andreas Fritsche, Andreas L Birkenfeld, Andreas Peter, Martin Heni, Sebastian Hörber
OBJECTIVE: Breastfeeding is associated with a reduced maternal risk for cardiovascular diseases. Since the underlying mechanisms are still poorly understood, we here examined the impact of breastfeeding on the plasmatic coagulation system in women with and without history of gestational diabetes mellitus (GDM). METHODS: 76 participants of the German Gestational Diabetes Study (PREG; NCT04270578) were examined 14 [interquartile range: 12-26] months after delivery with a 5-point oral glucose tolerance test...
March 15, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38487670/regulation-of-peripheral-tissue-substrate-metabolism-by-the-gut-derived-hormone-ghrelin
#36
REVIEW
Nicole M Notaro, David J Dyck
Ghrelin increases in the circulation prior to entrained mealtimes, with the acylated (AG) form functioning to stimulate food intake and growth hormone release. Acutely, AG induces whole-body insulin resistance, potentially to maintain glycemia between meals. Alternatively, chronic administration of both AG and the unacylated isoform of ghrelin (unAG) is associated with improved skeletal muscle insulin sensitivity as well as reduced intramuscular lipids and inflammation. This may be due to effects on lipid metabolism, with ghrelin promoting storage of fat in adipose and liver while stimulating oxidation in skeletal muscle, preventing ectopic lipid accumulation...
March 2024: Metabolism open
https://read.qxmd.com/read/38486011/the-individual-response-to-antibiotics-and-diet-insights-into-gut-microbial-resilience-and-host-metabolism
#37
REVIEW
Lars M M Vliex, John Penders, Arjen Nauta, Erwin G Zoetendal, Ellen E Blaak
Antibiotic use disrupts microbial composition and activity in humans, but whether this disruption in turn affects host metabolic health is unclear. Cohort studies show associations between antibiotic use and an increased risk of developing obesity and type 2 diabetes mellitus. Here, we review available clinical trials and show the disruptive effect of antibiotic use on the gut microbiome in humans, as well as its impact on bile acid metabolism and microbial metabolites such as short-chain fatty acids. Placebo-controlled human studies do not show a consistent effect of antibiotic use on body weight and insulin sensitivity at a population level, but rather an individual-specific or subgroup-specific response...
March 14, 2024: Nature Reviews. Endocrinology
https://read.qxmd.com/read/38485514/the-effect-of-artemisia-annua-l-aqueous-and-methanolic-extracts-on-insulin-signaling-in-liver-of-hfd-stz-diabetic-mice
#38
JOURNAL ARTICLE
S Mohammad Reza Seyedi Moqadam, Mohammad Shokrzadeh Lamuki, Forouzan Sadeghimahalli, Mahshid Ghanbari
OBJECTIVES: Many studies have shown the anti-diabetic effects of medicinal plants. But their molecular mechanism has been less studied. Understanding of these mechanisms can help to better manage the treatment of diabetes by using these plants. So, this research examined the effect of Artemisia annua extract on PI3K (phosphatidylinositol 3-kinase)/AKt (serine/threonine kinase protein B) signaling pathway in liver of high-fat diet (HFD)/Streptozotocin (STZ)-induced type 2 diabetic mice...
March 15, 2024: Journal of Complementary & Integrative Medicine
https://read.qxmd.com/read/38485342/jtt-654-an-11-beta-hydroxysteroid-dehydrogenase-type-1-inhibitor-improves-hypertension-and-diabetic-kidney-injury-by-suppressing-angiotensinogen-production
#39
JOURNAL ARTICLE
Shiro Heitaku, Tomohiko Sasase, Tomohiro Sotani, Mimi Maki, Takashi Kawai, Hisayo Morinaga, Jun Nishiu
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) plays an important role in regulating the expression of glucocorticoid actions in target tissues. Overexpression of 11β-HSD1 in mouse adipose tissue causes a metabolic syndrome-like phenotype, leading to hypertension. Although, many 11β-HSD1 inhibitors have been studied, few have shown a clear ameliorative effect against hypertension. We investigated whether JTT-654, a novel 11β-HSD1 inhibitor, ameliorated hypertension and elucidated the underlying mechanisms...
April 2024: Journal of Pharmacological Sciences
https://read.qxmd.com/read/38484502/intra-nanoparticle-plasmonic-nanogap-based-spatial-confinement-sers-analysis-of-polypeptides
#40
JOURNAL ARTICLE
Ruili Li, Yuyang Hu, Xiaotong Sun, Zhipeng Zhang, Kecen Chen, Qi Liu, Xiaoqing Chen
Sensing and characterizing water-soluble polypeptides are essential in various biological applications. However, detecting polypeptides using Surface-Enhanced Raman Scattering (SERS) remains a challenge due to the dominance of aromatic amino acid residues and backbones in the signal, which hinders the detection of non-aromatic amino acid residues. Herein, intra-nanoparticle plasmonic nanogap were designed by etching the Ag shell in Au@AgNPs (i.e., obtaining AuAg cores) with chlorauric acid under mild conditions, at the same time forming the outermost Au shell and the void between the AuAg cores and the Au shell (AuAg@void@Au)...
March 9, 2024: Talanta
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