Chang-Yong Xu, Ji Jiang, Yue An, Peng-Fei Ye, Cun-Cun Zhang, Ning-Ning Sun, Sai-Nan Miao, Meng-Qi Chai, Wen-Min Liu, Mei Yang, Wei-Hua Zhu, Jing-Jing Yu, Man-Man Yu, Wu-Yi Sun, Huan Qiu, Shi-Hao Zhang, Wei Wei
The angiotensin II type 2 receptor (AT2R) is a well-established component of the renin-angiotensin system and is known to counteract classical activation of this system and protect against organ damage. Pharmacological activation of the AT2R has significant therapeutic benefits, including vasodilation, natriuresis, anti-inflammatory activity, and improved insulin sensitivity. However, the precise biological functions of the AT2R in maintaining homeostasis in liver tissue remain largely unexplored. In this study, we found that the AT2R facilitates liver repair and regeneration following acute injury by deactivating Hippo signaling and that interleukin-6 transcriptionally upregulates expression of the AT2R in hepatocytes through STAT3 acting as a transcription activator binding to promoter regions of the AT2R...
March 15, 2024: Acta Pharmacologica Sinica